CN109170086A - A kind of chlorella pyrenoidosa pressed candy and preparation method thereof with immune enhancing function - Google Patents
A kind of chlorella pyrenoidosa pressed candy and preparation method thereof with immune enhancing function Download PDFInfo
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- CN109170086A CN109170086A CN201810519411.XA CN201810519411A CN109170086A CN 109170086 A CN109170086 A CN 109170086A CN 201810519411 A CN201810519411 A CN 201810519411A CN 109170086 A CN109170086 A CN 109170086A
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- China
- Prior art keywords
- chlorella pyrenoidosa
- maltodextrin
- weight
- lycium ruthenicum
- pressed candy
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-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The chlorella pyrenoidosa pressed candy and its specific preparation method that the invention discloses a kind of with immune enhancing function.Pressed candy preparation process of the present invention is simple, mainly it is made of chlorella pyrenoidosa, lycium ruthenicum, composite aminophenol powder, oligofructose and maltodextrin, each ingredient organically combines, improve the nutritive effect of chlorella pyrenoidosa, with supplement needed by human body nutrition, the effect for enhancing immune function is a kind of in good taste, easy to carry, rich in nutrition content, the pressed candy food for being easily absorbed by the human body and eating.
Description
Technical field
The chlorella pyrenoidosa pressed candy that the present invention relates to a kind of with immune enhancing function and preparation method thereof is answered
With.
Background technique
Immunity refers to that body resists external invasion, safeguards the ability of homoiostasis.Human body relies on this function
It identifies " oneself " and " non-oneself " ingredient, is damaged caused by the antigenic substance or human body itself of human body to destroy and repel to enter
Hurt cell and tumour cell etc., to maintain the health of human body.Modern life rhythm is fast, and diet work and rest is irregular, more and more
There is immunocompromised in people, and in the hypodynamic situation of human immunity, bacterium, fungi in air all easily become cause of disease
Body causes body that disease occurs, therefore safeguards the stabilization of vivo environment, improves immunity of organisms, and keeping body health is that people are current
The problem for needing to solve.
With the improvement of people ' s living standards and the development of technology, people more focus on the health care of daily life.Dietotherapy
Health passes through dietetic regulation body, is the traditional habit of Chinese, and most direct Curing Method.Enhance currently on the market
There are many varieties of food items of body's immunity, but most of there is edible not high with inconvenient to carry, degree of being absorbed and utilized and mouthfeel
The problems such as bad.Trophism pressed candy is because it is with easy to carry in recent years, in good taste and draw the advantages of be good for one's health
The concern for playing people, can not only serve as food, but also contain functional component, the effect that can be played and adjust body, help health, extensively
Liked by modern people.
Chlorella pyrenoidosa is resourceful, and nutritive value is high, and domestic and foreign scholars are research shows that it has enhancing immunity of organism
The effect of function, the in recent years favor as new resource food and by consumer.In order to preferably meet consumer demand, this
Invention proposes a kind of chlorella pyrenoidosa pressed candy and preparation method thereof with strengthen immunity.
Summary of the invention
The purpose of the present invention is to provide a kind of chlorella pyrenoidosa pressed candy and its system with immune enhancing function
The application of Preparation Method, the pressed candy are mainly made of the bulk pharmaceutical chemicals of following parts by weight:
Chlorella pyrenoidosa 250-350, lycium ruthenicum 50-150, composite aminophenol powder 30-70, oligofructose 15-25, malt
Dextrin 20-30, magnesium stearate 3-7.
The weight part ratio of the bulk pharmaceutical chemicals of the present composition is preferred are as follows:
Chlorella pyrenoidosa 250, lycium ruthenicum 150, composite aminophenol powder 30, oligofructose 25, maltodextrin 30, stearic acid
Magnesium 3.
The weight part ratio of the bulk pharmaceutical chemicals of the present composition is also preferably:
Chlorella pyrenoidosa 300, lycium ruthenicum 100, composite aminophenol powder 50, oligofructose 20, maltodextrin 25, stearic acid
Magnesium 5.
The weight part ratio of the bulk pharmaceutical chemicals of the present composition is also preferably:
Chlorella pyrenoidosa 350, lycium ruthenicum 50, composite aminophenol powder 70, oligofructose 15, maltodextrin 20, stearic acid
Magnesium 7.
Chlorella is distributed widely in nature, is easy to cultivate, and can not only utilize photoautotrophy, moreover it is possible to sharp under the conditions of heterotrophism
Growth and breeding is carried out with organic carbon source, it is that uniquely can increase by 4 times of biology in 20h in animals and plants on the earth that the speed of growth is fast,
Protein content height (50% or more), by as excellent protein source, nutritive value is very high.The common type in China has egg
White nucleus chlorella, chlorella ellipsoidea and chlorella vulgaris etc., wherein chlorella pyrenoidosa protein content is high, and nutritive value is most
It is high.Existing research shows chlorella pyrenoidosa containing protein abundant, lipid, polysaccharide, dietary fibre, vitamin, microelement
And active metabolite, have strengthen immunity, it is anti-oxidant, it is antitumor the effects of, polysaccharide and glycoprotein are by foreign scholar
Prove that there are the pharmacological activity such as anti-tumor activity, anti-microbial pathogen, viral infection resisting and strengthen immunity.
Lycium ruthenicum, rich in a variety of battalion such as protein, amino acid, polysaccharides, various vitamins, microelement, minerals
It forms point, mauve pigment abundant is contained inside fruit, and the main component of pigment is anthocyanin, research finds lycium ruthenicum anthocyanin
Have the function of anti-oxidant, anti-aging, improve immunity etc..Procyanidine (OPC) content of lycium ruthenicum is highest so far
Wild plant, therefore also it is known as " soft gold ".Tibetan medicine is for treating heart disease, reducing cholesterol, excited cerebral nerve, increasing
Strong immune function, anti-curing cancers, anti-aging, beautifying face and moistering lotion, irregular menstruation etc. and drug effect is significant.
Composite aminophenol powder is extracted from animal protein full of nutrition with scientific method, by asparagine
Acid, serine, threonine, glycine, alanine, picks propylhomoserin, moon bright propylhomoserin, tyrosine, leucine, isoleucine, dried meat at glutamic acid
17 kinds of amino acid such as propylhomoserin, histidine, lysine, arginine, methionine, phenylalanine form according to a certain ratio.For white
It is powdered, there is the mixed special aromatic odor of a variety of amino acid, soluble easily in water, the total content of the amino acid in finished product reaches
80% or so, also containing a variety of elements needed by human such as calcium, iron.It can directly take orally, be more suitable for addition in food, beverage
In eat, the deficiency of the various amino acid intakes of human body can be supplemented, to human body synthetic proteins matter, replenished the calcium, significant effect of enriching blood.
Oligofructose pure taste, it is sweet and dilitious, there is the adipose fragrance of class and tasty and refreshing soapy feeling, not only have one
As functional oligose physicochemical properties, moreover it is possible to be obviously improved microbial population ratio in enteron aisle, be enteral Bifidobacterium
The activation and proliferation factor, can reduce and inhibit the generation of enteral corrupt substance, inhibit the growth of harmful bacteria, adjust in enteron aisle and put down
Weighing apparatus.It can not only promote the absorption and utilization of trace elements iron, calcium, prevent osteoporosis, moreover it is possible to anticancer is generated in intestines
Organic acid reduces hepatotoxin, has significant preventing cancer function.
Maltodextrin has sugariness low, and dissolubility is good, is not easy the moisture absorption, and stability is good, it is difficult to it is rotten, it is easy to digest the features such as.
In addition to containing a large amount of polysaccharide, also beneficial to human body containing calcium, iron etc. microelement and minerals can promote maltodextrin
The metabolism of human normal has been widely used in the industries such as beverage, frozen food, candy, oatmeal, dairy products, health care product.
Pressed candy of the present invention is mainly pasted by chlorella pyrenoidosa, lycium ruthenicum, composite aminophenol powder, oligofructose and malt
The composition such as essence, can supplement needed by human body nutrition, have the effect of enhancing body's immunity, delaying senility, in good taste, carrying side
Just, it is easy to edible and absorption of human body.
Pressed candy of the present invention mainly consists of the following steps:
(1) it weighs, cleans according to bulk pharmaceutical chemicals weight ratio；
(2) chlorella pyrenoidosa, lycium ruthenicum, composite aminophenol powder, low fructan, maltodextrin are dried respectively,
It crushes, crosses 80 meshes, it is spare；
(3) fine powder obtained by step (2) is mixed into high-speed mixer 10min, is added in uniformly mixed mixed powder
95% edible alcohol carries out wet granulation, crosses 20 meshes, obtains wet granular；
(4) particle is placed in boiling drier, drying temperature is 50-60 DEG C, drying time 40-50min, until particle water
When dividing < 5%, takes out particle and be cooled to room temperature, cross 20 mesh sieves；
(5) particle after whole grain is set with magnesium stearate (crossing 80 meshes) and is mixed in three eccentricity mixing machine 20 minutes, tabletting,
Adjusting slice weight is 0.5g/ piece, carries out exterior and interior packing, is examined to get finished product.
Specific embodiment
Below with reference to embodiment, technical solution of the present invention is described in further detail, but is not constituted to the present invention
Any restrictions.
Raw material used in following embodiment is commercial goods, can buy gained from market.
Embodiment 1
Prescription:
Chlorella pyrenoidosa 250, lycium ruthenicum 150, composite aminophenol powder 30, oligofructose 25, maltodextrin 30, stearic acid
Magnesium 3.
Preparation method:
(1) it weighs, cleans according to bulk pharmaceutical chemicals weight ratio；
(2) chlorella pyrenoidosa, lycium ruthenicum, composite aminophenol powder, low fructan, maltodextrin are dried respectively,
It crushes, crosses 80 meshes, it is spare；
(3) fine powder obtained by step (2) is mixed into high-speed mixer 10min, is added in uniformly mixed mixed powder
95% edible alcohol carries out wet granulation, crosses 20 meshes, obtains wet granular；
(4) particle is placed in boiling drier, drying temperature is 50-60 DEG C, drying time 40-50min, until particle water
When dividing < 5%, takes out particle and be cooled to room temperature, cross 20 mesh sieves；
(5) particle after whole grain is set with magnesium stearate (crossing 80 meshes) and is mixed in three eccentricity mixing machine 20 minutes, tabletting,
Adjusting slice weight is 0.5g/ piece, carries out exterior and interior packing, is examined to get finished product.
Embodiment 2
Prescription:
Chlorella pyrenoidosa 300, lycium ruthenicum 100, composite aminophenol powder 50, oligofructose 20, maltodextrin 25, stearic acid
Magnesium 5.
Preparation method:
(1) it weighs, cleans according to bulk pharmaceutical chemicals weight ratio；
(2) chlorella pyrenoidosa, lycium ruthenicum, composite aminophenol powder, low fructan, maltodextrin are dried respectively,
It crushes, crosses 80 meshes, it is spare；
(3) fine powder obtained by step (2) is mixed into high-speed mixer 10min, is added in uniformly mixed mixed powder
95% edible alcohol carries out wet granulation, crosses 20 meshes, obtains wet granular；
(4) particle is placed in boiling drier, drying temperature is 50-60 DEG C, drying time 40-50min, until particle water
When dividing < 5%, takes out particle and be cooled to room temperature, cross 20 mesh sieves；
(5) particle after whole grain is set with magnesium stearate (crossing 80 meshes) and is mixed in three eccentricity mixing machine 20 minutes, tabletting,
Adjusting slice weight is 0.5g/ piece, carries out exterior and interior packing, is examined to get finished product.
Embodiment 3
Prescription:
Chlorella pyrenoidosa 350, lycium ruthenicum 50, composite aminophenol powder 70, oligofructose 15, maltodextrin 20, stearic acid
Magnesium 7.
Preparation method:
(1) it weighs, cleans according to bulk pharmaceutical chemicals weight ratio；
(2) chlorella pyrenoidosa, lycium ruthenicum, composite aminophenol powder, low fructan, maltodextrin are dried respectively,
It crushes, crosses 80 meshes, it is spare；
(3) fine powder obtained by step (2) is mixed into high-speed mixer 10min, is added in uniformly mixed mixed powder
95% edible alcohol carries out wet granulation, crosses 20 meshes, obtains wet granular；
(4) particle is placed in boiling drier, drying temperature is 50-60 DEG C, drying time 40-50min, until particle water
When dividing < 5%, takes out particle and be cooled to room temperature, cross 20 mesh sieves；
(5) particle after whole grain is set with magnesium stearate (crossing 80 meshes) and is mixed in three eccentricity mixing machine 20 minutes, tabletting,
Adjusting slice weight is 0.5g/ piece, carries out exterior and interior packing, is examined to get finished product.
In order to confirm the present invention have the function of increase immunity of organisms, with press 2 method of embodiment made of pressed candy,
Carry out animal experiment study:
1 experimental material
High, medium and low three dosage groups are made by pressed candy made of 2 method of embodiment, dosage is respectively as follows: 100mg/
mL,50mg/mL,25mg/mL.SPF grades of male mice in kunming, weight (20 ± 2) g, by Guangdong Medical Lab Animal Center
It provides.Dinitrofluorobenzene (DNFB), acetone, sesame oil, barium sulphide, sheep erythrocyte (CSRBC), physiological saline, chicken red blood cell,
Methanol, Giemsa dye liquor.
2 experimental methods
2.1 dosage be grouped mouse environment adapt to three days after, be randomly divided into negative control group, low dose group, middle dose group and
4 groups of high dose group, every group 10, by 0.4mL/20gBW, basic, normal, high difference is given in stomach-filling once a day to each test group respectively
2 solution of embodiment of dosage, then the distilled water of same volume is given in stomach-filling to negative control group, and continuous 30 days, according to the Chinese people
" health food functional evaluation program and the method for inspection " that the Ministry of Public Health of republic promulgates evaluates chlorella pyrenoidosa pressed candy
Immune function.
The evaluation of 2.2 non-specific immune functions 24 hours after the last administration, cervical dislocation put to death mouse, win thymus gland and
Spleen, weighing, is indicated with the ponderal index mg/10g (weight) of thymus gland and spleen, compares group difference.
Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment (half intracorporal method): take chicken blood in the sterilizing taper for having bead
It in bottle, is shaken towards fixed-direction, de-fibering, with brine 3 times, is often inferior to 2000r/min, is centrifugated 10min,
Supernatant is removed, the chicken erythrocyte suspension of 20% (v/v) is made into physiological saline, every mouse peritoneal injects suspension 1mL, interval
After 30min, cervical dislocation puts to death mouse, and is faced upward position and be fixed on mouse plate, and abdominal skin is cut off in center, raw through Intraperitoneal injection
Salt water 2mL is managed, mouse plate 1min is rotated, abdominal cavity washing lotion 1mL average mark drop is sucked out on 2 glass slides, is put into and is lined with wet gauze
In enamel box, in 37 DEG C of incubation 30min.It incubates complete, sets in physiological saline and rinse, remove non-patch cell, dry, with 1: 1
Acetone methanol solution is fixed, and 4% (v/v) Giemsa- phosphate buffer dyes 3min, then is dried with distilled water rinsing.Under oil mirror
Macrophage is counted, every piece counts 100, phagocytic percentage and phagocytic index is calculated as follows.
Phagocytic percentage (%)=[phagocyte number/counting number of macrophages of phagocytosis chicken red blood cell] × 100%
Chicken red blood cell sum/counting the number of macrophages for phagocytic index=swallowed
The evaluation of 2.3 cellular immune functions is first lost hair or feathers within the scope of mouse part skin about 3cm × 3cm with barium sulphide, then
Sensitization is uniformly smeared with 50 μ L of DNFB solution.After 5 days, mouse right ear two sides is uniformly applied to the DNFB solution of 10 μ L and is attacked
It hits, after attack 24 hours, cervical dislocation puts to death mouse, cuts left and right auricular concha, the auricle of diameter 8mm is removed with punch, respectively
Weighing, using the difference of left and right auricle weight as swelling, is calculated as follows swelling rate:
Swelling rate (%)=[(test one control sides of side)/control sides] × 100%
2.4 humoral immune functions are evaluated from sheep taking blood from jugular vein, are put into the sterilizing conical flask of bead, towards one
Fixed-direction shakes, de-fibering, is washed 3 times with physiology salt, is often centrifugated 10min inferior to 2000r/min, by overstocked silk floss
Sheeps blood erythrocyte is made into the cell suspension of 2% (v/v) with physiological saline, and every mouse peritoneal injection 0.2mL is immunized.5 days
Afterwards, extracing eyeball takes blood in centrifuge tube, stands 1 hour, solidification blood and tube wall are removed, serum is precipitated sufficiently, in
2000r/min is centrifugated 10min, collects serum.With physiological saline by serum doubling dilution, and by the blood of different dilutions
It being respectively placed in Microhemagglutination breadboard clearly, every 100 μ L of hole adds the sheep erythrocyte suspension of 100 μ L0.5% (v/v),
Mix well, be packed into wet square position and cover, in 37 DEG C incubation 3 hours, observe hemagglutination degree, and calculating antibody
Product.
Antibody product calculation formula is as follows:
Antibody product=(S1+2S2+3S3+......+nSn)
Wherein 1,2,3......n is the index to doubling dilution, and S refers to the rank of condensation degree.
0 grade of red blood cell all sinks, and concentrates on hole bottom and forms fine and close round point shape, surrounding liquid clear.
Largely for heavy collection in bottom hole at round point shape, surrounding has the red blood cell being aggregated on a small quantity to 1 grade of red blood cell.
The red blood cell of 2 grades of agglutinations forms thin layer in bottom hole, and center can obviously see a loose red dot.
The uniform shakedown of red blood cell of 3 grades of agglutinations is dispersed in bottom hole into a thin layer, and may be seen indistinctly a small red dot at center.
The uniform shakedown of red blood cell of 4 grades of agglutinations is dispersed in bottom hole into a thin layer, and grumeleuse is sometimes at convolution shape.
2.4 statistical analysis test data statistics carry out variance analysis using 11.0 forwindows software of SPSS.
3 experimental results
The evaluation thymus gland of 3.1 non-specific immune functions is the cradle of T cell, is the center organ of immune system, spleen
Dirty is the filtration organ in blood access, is the maximum immune organ of body, is the place of residence of B cell.Spleen index rises, and shows
Proliferation and antibody to bone-marrow-derived lymphocyte have facilitation.Seen from table 1, life of the mouse of negative control group at 30 days
Length is interim, and weight mean value has been raised significantly to 40.92 grams by original 19.55 grams, in the test group of basic, normal, high three dosage
The increase trend of test mice weight is all not significantly different with negative control group.The spleen index mean value of the mouse of negative control group
Be respectively 0.42mg/10g weight and 0.18mg/10g weight with thymus index mean value, three test groups no matter spleen index mean value also
It is that thymus index mean value is all not significantly different with negative control group.
1 chlorella pyrenoidosa pressed candy of table to mouse immune organ weights influence (N=10)
Contain a large amount of phagocyte in the lymphocyte that immune organ generates, in general immunity and removes itself aging
Red blood cell etc. in important function.With advancing age with the aging of body, hypoimmunity, thymus gland and spleen meeting
It gradually degenerates and atrophy, immunostimulant can be such that low immune function and immune internal organs restores to normal level.Macrophage
Main antigen presentation is played in the primary stage of immune response, has the function of panimmunity, is nospecific immunity
Key factor.Influence of the embodiment 2 to mouse macrophage phagocytic activity is from the data result of table 2 it can be seen that negative control
The phagocytic rate mean value of the macrophage of group is 15.41%, the corresponding abdominal cavity macrophage phagocytosis mean value of basic, normal, high three dosage groups
Respectively 16.97%, 23.06% and 26.56%, it is seen that phagocytic rate is constantly raised as the increase of sample dose presents
Trend, and the reinforcing effect statistical analysis of middle and high dosage group has significant difference；The phagocytosis of the macrophage of negative control group
Mean value of index is 0.2108, and the corresponding macrophage phagocytic index mean value of three dosage groups is respectively 0.2386,0.3271 He
0.3523, it is seen that phagocytic index continuous raised trend as the increase of sample dose presents, similarly, middle and high dosage
The reinforcing effect of group has significant difference through SPSS statistical analysis.
2 chlorella pyrenoidosa pressed candy of table nospecific immunity effect (phagocytic rate and phagocytic index) (N=
10)
3.2 cellular immune functions evaluate 2 test group of animals of embodiment to tardy caused by 2,4-dinitrofluorobenzene (DNFB)
Allergic reaction type enhancing is because of the increased reason of internal antibody, and after body is stimulated by antigen DNFB, T cell sensitization is simultaneously
Mass propagation, when again with antigen contact, the T cell of sensitization is just divided into lymphocyte and discharges various lymphokines, to attack
Target cell is hit, so as to cause the inflammatory reaction based on local lymphocytes inflammation.Represent the difference of the auricle weight of oedema degree
Increase, the cellular immune function of body can be improved by representing 2 sample of embodiment.As shown in Table 3, with the increase of test dose, low,
There is ever-increasing trend in the mouse ear swelling rate of middle and high three dosage groups, wherein the delayed of middle and high dosage group is abnormal
Reaction significantly increases compared with negative control group.
3 chlorella pyrenoidosa pressed candy of table to mouse Tardive allergy influence (ear swelling method) (N=
10)
It is a kind of T cell dependence antigen that 3.3 humoral immune functions, which evaluate sheep red blood cell (SRBC) SRBC, in the participation of T cell
Under, stimulation generates corresponding antibody (hemolysin) by the body of sensitization.Antibody product increases, and reflects B cell and generates antibody
Ability enhancing.Basic, normal, high three dosage groups 2 solution of embodiment confrontation volume number increase have significant ground facilitation (see
Table 4), the antibody product phase average ratio with negative control group 10.4, corresponding antibody product mean value has increased respectively to 22.26,
32.38 and 50.22, moreover, there is also significant differences between various dose group.
4 chlorella pyrenoidosa pressed candy of table to mouse antibodies number influence (N=10)
4 experiment conclusions
Experimental result shows that 2 low dose group of embodiment only shows the knot significantly increased in the test of humoral immunity
Fruit, and middle and high dosage group shows in the test of nospecific immunity, cellular immunity and humoral immunity and significantly to increase
As a result, sufficiently illustrating chlorella pyrenoidosa pressed candy with stronger immunological regulation effect, immunity of organism function can be enhanced
Energy.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (5)
1. a kind of chlorella pyrenoidosa pressed candy and preparation method thereof with immune enhancing function, it is characterised in that by following
The bulk pharmaceutical chemicals of parts by weight are made: chlorella pyrenoidosa 250-350, lycium ruthenicum 50-150, composite aminophenol powder 30-70, oligomeric fruit
Sugared 15-25, maltodextrin 20-30, magnesium stearate 3-7.
2. application according to claim 1, it is characterised in that be made of the bulk pharmaceutical chemicals of following parts by weight:
Chlorella pyrenoidosa 250, lycium ruthenicum 150, composite aminophenol powder 30, oligofructose 25, maltodextrin 30, magnesium stearate 3.
3. application according to claim 1, it is characterised in that be made of the bulk pharmaceutical chemicals of following parts by weight:
Chlorella pyrenoidosa 300, lycium ruthenicum 100, composite aminophenol powder 50, oligofructose 20, maltodextrin 25, magnesium stearate 5.
4. application according to claim 1, it is characterised in that be made of the bulk pharmaceutical chemicals of following parts by weight:
Chlorella pyrenoidosa 350, lycium ruthenicum 50, composite aminophenol powder 70, oligofructose 15, maltodextrin 20, magnesium stearate 7.
5. application according to claim 1-4, it is characterised in that the pressed candy is mainly by following steps group
At:
(1) it weighs, cleans according to bulk pharmaceutical chemicals weight ratio；
(2) chlorella pyrenoidosa, lycium ruthenicum, composite aminophenol powder, low fructan, maltodextrin are dried respectively, are crushed,
80 meshes are crossed, it is spare；
(3) fine powder obtained by step (2) is mixed into high-speed mixer 10min, 95% is added in uniformly mixed mixed powder
Edible alcohol carries out wet granulation, crosses 20 meshes, obtains wet granular；
(4) particle is placed in boiling drier, drying temperature is 50-60 DEG C, drying time 40-50min, until pellet moisture <
When 5%, takes out particle and be cooled to room temperature, cross 20 mesh sieves；
(5) particle after whole grain is set with magnesium stearate (crossing 80 meshes) and is mixed in three eccentricity mixing machine 20 minutes, tabletting is adjusted
Slice weight is 0.5g/ piece, carries out exterior and interior packing, is examined to get finished product.
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Cited By (6)
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| CN110236093A (en) * | 2019-07-13 | 2019-09-17 | 桐乡市博奥生物科技有限公司 | A kind of northern Chinese caterpillar Fungus health nutrient meal |
| CN110250411A (en) * | 2019-07-13 | 2019-09-20 | 桐乡市博奥生物科技有限公司 | A kind of Saussurea involucrata culture health nutrient meal |
| CN110787193A (en) * | 2019-10-25 | 2020-02-14 | 青岛科海生物有限公司 | Chlorella effervescent tablet and preparation method thereof |
| CN112137056A (en) * | 2020-10-09 | 2020-12-29 | 东台市赐百年生物工程有限公司 | Special medical food based on chlorella pyrenoidosa and preparation method thereof |
| CN112237281A (en) * | 2020-10-29 | 2021-01-19 | 青岛科海生物有限公司 | Chlorella meal replacement powder for enhancing immunity and preparation method thereof |
| CN112401051A (en) * | 2020-11-24 | 2021-02-26 | 新余市天麦食品有限公司 | Purple Chinese yam caramel treats and processing technology thereof |
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| CN105613918A (en) * | 2014-12-01 | 2016-06-01 | 哈尔滨墨医生物技术有限公司 | Euglena compound tableting candy and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110236093A (en) * | 2019-07-13 | 2019-09-17 | 桐乡市博奥生物科技有限公司 | A kind of northern Chinese caterpillar Fungus health nutrient meal |
| CN110250411A (en) * | 2019-07-13 | 2019-09-20 | 桐乡市博奥生物科技有限公司 | A kind of Saussurea involucrata culture health nutrient meal |
| CN110787193A (en) * | 2019-10-25 | 2020-02-14 | 青岛科海生物有限公司 | Chlorella effervescent tablet and preparation method thereof |
| CN112137056A (en) * | 2020-10-09 | 2020-12-29 | 东台市赐百年生物工程有限公司 | Special medical food based on chlorella pyrenoidosa and preparation method thereof |
| CN112237281A (en) * | 2020-10-29 | 2021-01-19 | 青岛科海生物有限公司 | Chlorella meal replacement powder for enhancing immunity and preparation method thereof |
| CN112401051A (en) * | 2020-11-24 | 2021-02-26 | 新余市天麦食品有限公司 | Purple Chinese yam caramel treats and processing technology thereof |
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Application publication date: 20190111 |