CN104939098A - Health food capable of enhancing bone immunity and supplementing and locking calcium and preparation method of health food - Google Patents
Health food capable of enhancing bone immunity and supplementing and locking calcium and preparation method of health food Download PDFInfo
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Abstract
The invention is suitable for the field of nutrition and health care, and provides a health food capable of enhancing bone immunity and supplementing and locking calcium and a preparation method of the health food. The health food comprises the following components in percentage by weight: 35%-55% of bovine coloctrum, 0.5%-5.15% of colostrum basic protein, 35%-51.5% of calcium, 0.03%-0.10% of vitamin D and the balance of auxiliary materials. With calcium carbonate and vitamin D as raw materials, the colostrum basic protein is especially added to achieve the effect of supplementing and locking calcium on the basis of calcium supplementation; the capacity of a bone tissue for actively absorbing osteoblast nutrients such as calcium and ossein is improved; and meanwhile, the colostrum basic protein and the bovine coloctrum are used in combination, and can act together to achieve the effect of synergistic interaction.
Description
Technical field
The invention belongs to nutrition and health care field, particularly relate to a kind ofly strengthen bone immunity, the health food of lock calcium of replenishing the calcium and preparation method thereof.
Background technology
Immunity is the defense mechanism of human body self, sound immunologic function shows as the physiological function of immune defense, immunological homeostasis, immunosurveillance three aspect, namely body is to the anti-infection ability of sex pheromone, identify and remove the histiocytic ability of self aging, and the ability killed and wounded and remove abnormal sudden change cell, suppress malignant tumour to grow in vivo.The immunity of people be divided into innate immunity and the day after tomorrow adaptive immune power two kinds.The power of immunity is the external manifestation of human immune system's function quality, and direct relation the health of human body and the ability of resist the disease.World Health Organization's investigation display, the whole world has the people of 50% to have hypoimmunity problem, is necessary develop immunitypty, particularly developed country and the fast area of rhythm of life, and hypoimmunity problem is more outstanding.The crowd of China's hypoimmunity is extensive, wherein especially in the majority with white collar, intellectual, Enterprises Leader.Someone is in the health survey to National urban white collar elite in 2009 display, and the white collar crowd in main flow city has 76% to be in unhealthy condition.
Many reasons can cause immune system normally can not play protective effect, in the case, very easily causes the infection such as bacterium, virus, fungi, and the most directly performance is exactly liable to illness, and the health of hypoimmunity is easy to infected or cancer stricken.Immune system generally can be divided into humoral immunity and cellular immunity.Humoral immunity relates generally to the antibody that can be combined with various attack thing in human body, and they are class macro-molecular proteins, also referred to as immunoglobulin (Ig), comprises IgG, IgA, IgM and IgD, IgE five type.Cellular immunity relates generally to two large class cells: B cell and T cell, and T cell can be divided into cd4 cell and cd8 cell again; Functionally briefly, B cell can generate various antibody, and T cell inherently can be killed or engulf the various pathogen entered in body.
Advocating back to nature, pursuing today of natural green product, people thirst for the general level of the health and the quality of life that are improved self by adjustment of diet, extra-nutrition material, the object of reach health care, lengthening the life.The health food of develop immunitypty is roughly divided into four classes in the market:
1. animal foremilk health food: be the health food that raw material is made with animal foremilk, containing high-quality protein and immune protein in animal foremilk, can improve immunity of organisms.
2. plant nutrient health products: with natural or rare species for raw material, extracting the health products of effective nutritional labeling, as extracted albumen from soybean, extracting nutrients from the plants such as red bean, black soya bean, ginkgo leaf.The scarcely suitable children of this kind of health products and pregnant woman eat.
3. famous and precious animals and plants health products: with rare Chinese medicine or the tonic type health products that have the animals and plants of medical value to be primary raw material, as ginseng, pilose antler, glossy ganoderma, ginkgo etc.This kind of health products be generally applicable to friend person in middle and old age take, but and be not suitable for children taking, pregnant woman does not preferably also take.
4. vitamin and mineral matter health products: the auxotype health products being main component with vitamin and mineral matter, this kind of health products are mainly containing vitamin and mineral matter.These nutrients are needed by human body, and some easily lacks, not easily from common food, absorb enough amounts, also just like special populations such as pregnant woman, wet nurse, children, need to increase consumption.
Summary of the invention
The object of the invention is to: provide a kind of and strengthen bone immunity, the health food of lock calcium of replenishing the calcium, be intended to solve existing develop immunitypty health food and be suitable for crowd's narrow range, the immunity imperfect problem of enhancing effect.
The health food of described enhancing bone immunity provided by the invention, lock calcium of replenishing the calcium comprises the composition of following percentage by weight:
Described calcium can be one or more in the substantial equivalences such as calcium carbonate, milk calcium, calcium pantothenate, calcium lactate, calcium citrate, calcium acetate, amino acid chelated calcium, calcium gluconae, Chinese holly edge tart apple acid calcium.Described colostrum refers to that healthy cow divides milk secreted within one week puerperium.Vitamin containing multiple growth factor, immunoglobulin (Ig), biologically active peptide-binding proteins and needed by human body in colostrum and trace element; its nutritive value exceeds several times, common cow's milk to tens times; and containing a large amount of immune factors and growth factor isoreactivity composition; to the effect improving body immunity, prevent disease has uniqueness; it can also reduce the dependence of the raw element of body fight simultaneously; any side effect can not be produced, at any time all can the health of available protecting health.The present invention adds the new resource food just milk basic protein (CBP) that health ministry is announced especially, first milk basic protein take colostrum as raw material, through sterilization, degreasing, centrifugation, removal casein, ALA, beta lactoglobulin, the molecular weight that the techniques such as micro-filtration, ultrafiltration, freeze drying are made is the condensing protein of 1-30KD, the rare albumen do not had in other dairy products, be worth high as Small molecular concentrated alkaline nutrient protein, good absorbing.CBP can directly act on bone cells, promotes bone metabolism, promotes bone growth, repair sclerotin, reach comprehensive reparation and the regeneration effect of bone.Containing BGP, osteonectin, bone bridge element (OPN), bone morphogenetic protein (BMP) and alkaline phosphatase (ALP) etc. in CBP.Wherein, BMP and ALP participates in each stage of Bone m etabolism, the inside and outside film of bone and marrow stromal cell can be induced to be divided into osteoblast, there is the effect strengthening bone bed power of regeneration, generation for immunocyte provides sufficient source, can also induced animal or human mesenchymal's Cell Differentiation be skeletonization, cartilage, ligament, tendon and nerve fiber, guarantee marrow peripheral tissues strong, avoid damaging and suffer the invasion and attack of germ, causing bone hypoimmunity; BGP then can help " packing " calcium constituent in bone, is synthesized and be secreted in bone by Gegenbaur's cell, adjustable and maintenance bone calcium.Calcium is the trace element of needed by human, has important physiological function, can activate the immunocompetence with the lymphokine in reinforcement, is also the signal of interest transduction molecule of regulation and control immune cell function simultaneously.Vitamin D is a kind of liposoluble vitamin, and main Physiological Function is Ca,P metabolism in control agent, maintains plasma calcium, phosphorus level, by promoting the absorption of calcium and then regulating different physiological roles.In addition, vitamin D is also used to the probability reducing colon cancer, breast cancer and prostate cancer, also has humidification to immune system.There are some researches show, when vitamin D deficiency, the ability that monocyte and macrophage start this natural immunity function just can be obstructed.
Above-mentioned every composition is all commercially available.
The preparation method of the health food of described enhancing bone immunity, lock calcium of replenishing the calcium is as follows:
1) calcium, colostrum, first milk basic protein, vitamin D, auxiliary material are pulverized respectively, sieve, obtain fine powder, for subsequent use.
2) the colostrum fine powder of formula rate, calcium fine powder are mixed in three-dimensional mixer, obtain mixed powder 1; First milk basic protein fine powder, auxiliary material fine powder are mixed, obtains mixed powder 2; Vitamin D fine powder recipe ratio arranged, according to the mixing of equal increments method, until mix complete by all mixed powders 2, obtains mixed powder 3.
3) in mixed powder 1, adhesive (such as HPC, HPMC, EC, PVP) ethanolic solution of certain proportioning is added and the softwood processed that stirs, softwood to be sieved granulation, obtain wet granular, then by dry for wet granular certain hour, sieve after the dry particle of system whole grain, obtains dry particle.
4) mixed powder 3 is mixed according to equal increments method with the dry particle in step 3), until by complete for all dry particle mixing, obtain total mixture.
5) above-mentioned total mixture is made granule, tablet or capsule etc. according to the market demand by prior art, pack and obtain product of the present invention.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Motherland's medical science is thought " the first nourishing the bone of health ".Nourishing the bone can be interpreted as from the angle of motherland's medical science: beneficial gas, nourish blood, strong essence, strong bone, improve physique thus prolong life.In order to strengthen the immunity of body, improve the sub-health states such as associated such as insomnia, fatigue and whole body discomfort, body is accomplished, and all kinds of diseases and ailments are not invaded, nourishing the bone is top priority, bone is not only people and other mammiferous blood forming organs, or the cradle of various immunocyte, bone health could provide sufficient " raw material " for the generation of immunocyte.Crowd's narrow range is suitable in order to solve market develop immunitypty health food, ignore bone sub-health state and the defects such as the develop immunitypty DeGrain that causes, the invention provides health food of a kind of develop immunitypty containing active ingredients such as colostrum, first milk basic protein, calcium carbonate, vitamin Ds and preparation method thereof.
Embodiment 1:
The health food of described enhancing bone immunity, lock calcium of replenishing the calcium comprises the composition of following percentage by weight:
The preparation process of the health food in the present embodiment is as follows:
1) calcium carbonate, colostrum, first milk basic protein, vitamin D, citric acid, orange flavor, Aspartame are pulverized respectively, sieve, obtain fine powder, for subsequent use.
2) the colostrum fine powder of formula rate, calcium carbonate fine powder are mixed 30min in three-dimensional mixer; Obtain mixed powder 1; By the vitamin D fine powder of formula rate, Aspartame fine powder according to the mixing of equal increments method, until by complete for the mixing of all Aspartame fine powders, obtain mixed powder 2; First milk basic protein fine powder, citric acid fine powder, orange flavor fine powder are mixed 30min with mixed powder 2, obtains mixed powder 3.
3) in mixed powder 1, add 10% PVP K30 ethanolic solution to stir softwood processed, granulation of being sieved by softwood, obtains wet granular, then by dry for wet granular certain hour, sieve after obtained dry particle, whole grain, obtain dry particle.
4) mixed powder 3 is mixed according to equal increments method with dry particle, until by complete for all dry particle mixing, obtain mixture 4, by mixture 4 and dolomol mixing 10min, obtain total mixture.
5) total mixture is placed in rotary tablet press, obtains tablet, pack and obtain product of the present invention.
Embodiment 2:
The health food of described enhancing bone immunity, lock calcium of replenishing the calcium comprises the composition of following percentage by weight:
The preparation process of the health food in the present embodiment is as follows:
1) calcium carbonate, colostrum, first milk basic protein, vitamin D, citric acid, lactic acid, orange flavor, Aspartame are pulverized respectively, sieve, obtain fine powder, for subsequent use.
2) the colostrum fine powder of formula rate, calcium carbonate fine powder are mixed 30min in three-dimensional mixer; Obtain mixed powder 1; By the vitamin D fine powder of formula rate, Aspartame fine powder according to the mixing of equal increments method, until by complete for the mixing of all Aspartame fine powders, obtain mixed powder 2; First milk basic protein fine powder, citric acid fine powder, lactic acid fine powder, orange flavor fine powder are mixed 30min with mixed powder 2, obtains mixed powder 3.
3) in mixed powder 1, add 10% PVP K30 ethanolic solution to stir softwood processed, granulation of being sieved by softwood, obtains wet granular, then by dry for wet granular certain hour, sieve after obtained dry particle, whole grain, obtain dry particle.
4) mixed powder 3 is mixed according to equal increments method with dry particle, until by complete for all dry particle mixing, obtain mixture 4, by mixture 4 and dolomol mixing 10min, obtain total mixture.
5) total mixture is placed in rotary tablet press, obtains tablet, pack and obtain product of the present invention.
Embodiment 3:
The health food of described enhancing bone immunity, lock calcium of replenishing the calcium comprises the composition of following percentage by weight:
The preparation process of the health food in the present embodiment is as follows:
1) calcium carbonate, colostrum, first milk basic protein, vitamin D, citric acid are pulverized respectively, sieve, obtain fine powder, for subsequent use.
2) the colostrum fine powder of formula rate, calcium carbonate fine powder are mixed 30min in three-dimensional mixer; Obtain mixed powder 1; By first milk basic protein fine powder, citric acid fine powder mixing 30min, after mixing, obtain mixed powder 2; By the vitamin D fine powder of formula rate according to the mixing of equal increments method, until mix complete by all mixed powders 2, obtain mixed powder 3.
3) in mixed powder 1, add 10% PVP K30 ethanolic solution to stir softwood processed, granulation of being sieved by softwood, obtains wet granular, then by dry for wet granular certain hour, sieve after the dry particle of system, whole grain, obtain dry particle.
4) mixed powder 3 is mixed according to equal increments method with dry particle, until by complete for all dry particle mixing, obtain mixture.
5) by step 4) namely gained mixture filled capsules, polishing obtain product of the present invention.
Develop immunitypty function test:
By described embodiment 1, embodiment 2, the health food that embodiment 3 provides carries out develop immunitypty animal function test respectively, namely body weight has been carried out respectively, internal organs/weight ratio pH-value determination pH (thymus gland/body weight ratio, spleen/body weight ratio), cellular immune function assay (mouse spleen lymphocyte conversion test, delayed allergy is tested), humoral immune function measures, and (antibody-producting cell detects, serum hemolysin measures), with NK cytoactive detection, immunologic function is evaluated, three embodiments press the gavage liquid of 10 times amount distilled water preparation respective concentration of human body RD respectively, as experimental group, control group is with aqua sterilisa gavage, gavage amount is 20ml/kg.bw, once a day, continuous gavage 30 days.
Result of the test comparison is as follows:
1, on the impact (see table 1-table 4) of rat body weight
Table 1 is on the impact (serum hemolysin, antibody-producting cell and delayed allergy mensuration group) of Mouse Weight
Known by table 1: serum hemolysin, antibody-producting cell and delayed allergy mensuration group Analysis of variance, each embodiment group compared with control group, difference that there are no significant (P>0.05)
Table 2 is on the impact (engulfing chicken red blood cell group) of Mouse Weight
Analysis of variance, each embodiment group compared with control group, difference that there are no significant (P>0.05).
Table 3 is on the impact (NK cytoactive detection and pouring turn mensuration group) of Mouse Weight
Analysis of variance, each embodiment group compared with control group, difference that there are no significant (P>0.05).
Table 4 is on the impact (carbonic clearance mensuration group) of Mouse Weight
Analysis of variance, each embodiment group compared with control group, difference that there are no significant (P>0.05).
2, on the impact (see table 5) of mice organs, body weight ratio
Table 5 is on the impact of mice organs/body weight ratio
Analysis of variance, each embodiment group compared with control group, its internal organs/body weight ratio, thymus gland/body weight ratio there are no significant difference (P>0.05).
3, cellular immune function test (mouse spleen lymphocyte conversion test, mouse delayed allergy test) result deck watch is in table 6 and table 7.
Table 6 is on the impact of mouse delayed allergy (DTH)
Antigen is attacked latter 24 hours, and each embodiment group is compared with control group, and its toes swelling all has significant difference (P < 0.05).
The impact that table 7 transforms mouse lymphocyte
| Group (mg/kg.bw) | Number of animals (only) | Optical density difference (X ± S) |
| Control group | 11 | 0.513±0.084 |
| Embodiment 1 | 11 | 0.639±0.101 |
| Embodiment 2 | 11 | 0.645±0.115 |
| Embodiment 3 | 11 | 0.633±0.103 |
Each embodiment group is compared with control group, and its optical density difference all has significant difference (P < 0.05).
4, humoral immune function measures (antibody-producting cell detects and serum hemolysin measures) and the results are shown in Table 8-table 10.
Table 8 is on the impact of mice serum hemolytic antibody product and mouse antibodies cellulation
Each embodiment group compared with control group, its antibody product and antibody-producting cell number there are no significant difference (P>0.05).
Table 9 engulfs the impact of chicken red blood cell ability to Turnover of Mouse Peritoneal Macrophages
Each embodiment group is compared with control group, and its peritoneal macrophage engulfs the phagocytic percentage of chicken red blood cell and phagocytic index all has significant difference (P < 0.01).
Table 10 is on the impact of mouse carbonic clearance
| Group (mg/kg.bw) | Number of animals (only) | Phagocytic index a(X ± S) |
| Control group | 11 | 5.56±0.66 |
| Embodiment 1 | 11 | 6.46±0.73 |
| Embodiment 2 | 10 | 6.25±0.78 |
| Embodiment 3 | 10 | 6.43±0.80 |
Each embodiment group is compared with control group, and its phagocytic index a has significant difference (P < 0.05).
5, NK cytoactive detection the results are shown in Table 11.
Table 11 is on the impact of NK cells in mice activity
Each embodiment group compared with control group, its NK cytoactive rate there are no significant difference (P > 0.05).
Show according to above result of the test, the health food that described embodiment 1,2,3 provides all has significant develop immunitypty function.
Colostrum can suppress germ reproduction, is a kind of healthy functions food that can strengthen body immunity, promote tissue growth.It, except containing uniquely through except the wide spectrum IgG antibody of placenta, can also be rich in the immune substance such as lactoferrin, lactalbumin, also has a large amount of growth factors and milk calcium, can promote infant's bone growth, the healthy development of help physical function.Simultaneously, it is a kind of material bone being had to anabolic action that colostrum is identified as, find that wherein having this effect major physiological active material is a kind of small molecule active albumen-first milk basic protein (CBP) through a large amount of scientific experimentations, it can directly act on bone cells, promote bone metabolism, promote bone growth, repair sclerotin, reach comprehensive reparation and the regeneration effect of bone, improve bone immunity.But the content of CBP in colostrum is only 4/10000ths, this is also one of inapparent major reason of immune effect when why colostrum content is too low.The present invention selects calcium carbonate, vitamin D to be raw material; on the basis of replenishing the calcium; special interpolation is milk basic protein just; reach the effect of calcium of replenishing the calcium, lock; improve the ability that bone tissue active absorption calcium and ossein etc. make osteotrophy; simultaneously; first milk basic protein and colostrum compatibility use; the two can cooperate mutually, plays the effect of Synergistic, carries out general protection to bone and joint; ensure bone health; for the generation of endogenic immune cell is supplied raw materials, coordinate with ectogenic immune substance, play its develop immunitypty function to greatest extent.In addition, research also finds that alkaline components specific to CBP can maintain the stable of environment, avoids organismic internal environment be subject to the invasion and attack of acidic materials and cause hypoimmunity.Simultaneously, the present invention take colostrum as the food of primary raw material, the Immune-enhancing effect product that a kind of scope of application is very wide, no matter be children and adolescents, the elderly can take, it can combine with the diet of people, for carrying out prevention in China and finding that bone immunocompromised is significant early.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. strengthen bone immunity, replenish the calcium and lock a health food for calcium, it is characterized in that, described health food comprises the composition of following percentage by weight:
2. the health food of enhancing bone immunity as claimed in claim 1, lock calcium of replenishing the calcium, it is characterized in that, described health food comprises the composition of following percentage by weight:
3. the health food of enhancing bone immunity as claimed in claim 1, lock calcium of replenishing the calcium, it is characterized in that, described health food comprises the composition of following percentage by weight:
4. the health food of enhancing bone immunity as claimed in claim 1, lock calcium of replenishing the calcium, it is characterized in that, described health food comprises the composition of following percentage by weight:
5. the preparation method of the health food of enhancing bone immunity as claimed in claim 1, lock calcium of replenishing the calcium, it is characterized in that, described method comprises the steps:
Calcium, colostrum, first milk basic protein, vitamin D, auxiliary material are pulverized respectively, sieves, obtain fine powder, for subsequent use;
The colostrum fine powder of formula rate, calcium fine powder are mixed in three-dimensional mixer, obtains mixed powder 1; First milk basic protein fine powder, auxiliary material fine powder are mixed, obtains mixed powder 2; Vitamin D fine powder recipe ratio arranged, according to the mixing of equal increments method, until mix complete by all mixed powders 2, obtains mixed powder 3;
In mixed powder 1, add the adhesive ethanolic solution of certain proportioning and the softwood processed that stirs, granulation of being sieved by softwood, obtains wet granular, then by dry for wet granular certain hour, sieve after the dry particle of system whole grain, obtains dry particle;
Mixed powder 3 is mixed according to equal increments method with dry particle, until by complete for all dry particle mixing, obtain total mixture.
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| CN105996049A (en) * | 2016-06-15 | 2016-10-12 | 天津天狮生物发展有限公司 | Child instant medicine for boosting immunity |
| CN114343187A (en) * | 2021-12-27 | 2022-04-15 | 北京康比特体育科技股份有限公司 | Health beverage containing collagen tripeptide and preparation method thereof |
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