CN104936951B - 作为激酶抑制剂的苯并咪唑衍生物 - Google Patents

作为激酶抑制剂的苯并咪唑衍生物 Download PDF

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CN104936951B
CN104936951B CN201380067040.1A CN201380067040A CN104936951B CN 104936951 B CN104936951 B CN 104936951B CN 201380067040 A CN201380067040 A CN 201380067040A CN 104936951 B CN104936951 B CN 104936951B
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independently selected
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substituted
heterocycle
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CN104936951A (zh
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沃伊切赫·察尔迪邦
克日什托夫·布若佐卡
米夏尔·加莱佐夫斯基
雷娜塔·温达克
马里乌什·米利克
玛格达莱娜·扎瓦兹卡
帕维尔·古济克
埃韦利纳·温恰
玛尔塔·普罗科普
卡塔日娜·维克利克
亚历山德拉·萨比尼亚日
维斯瓦夫·马雷克·乔洛迪
雷蒙德·霍尔瓦特
托马斯·日姆斯基
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Ruiwu Treatment Co ltd
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Selvita Sp zoo
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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  • Dermatology (AREA)
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  • Hematology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
CN201380067040.1A 2012-12-21 2013-12-20 作为激酶抑制剂的苯并咪唑衍生物 Active CN104936951B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1223265.8 2012-12-21
GBGB1223265.8A GB201223265D0 (en) 2012-12-21 2012-12-21 Novel benzimidazole derivatives as kinase inhibitors
PCT/EP2013/077754 WO2014096388A2 (en) 2012-12-21 2013-12-20 Novel benzimidazole derivatives as kinase inhibitors

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CN104936951A CN104936951A (zh) 2015-09-23
CN104936951B true CN104936951B (zh) 2018-02-06

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US (2) US9388192B2 (https=)
EP (1) EP2935244B1 (https=)
JP (1) JP6169185B2 (https=)
KR (1) KR101779272B1 (https=)
CN (1) CN104936951B (https=)
AU (1) AU2013366513B2 (https=)
BR (1) BR112015014701B8 (https=)
CA (1) CA2896156C (https=)
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GB (1) GB201223265D0 (https=)
HR (1) HRP20181429T8 (https=)
HU (1) HUE039376T2 (https=)
IL (1) IL239193A0 (https=)
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MX (1) MX369589B (https=)
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PT (1) PT2935244T (https=)
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GB201223265D0 (en) 2012-12-21 2013-02-06 Selvita Sa Novel benzimidazole derivatives as kinase inhibitors
WO2015108881A1 (en) 2014-01-14 2015-07-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
AU2015206652A1 (en) 2014-01-14 2016-08-04 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
MA41051B1 (fr) 2014-10-06 2020-11-30 Vertex Pharma Modulateurs du régulateur de conductance transmembranaire de la mucoviscidose
EP3344039A4 (en) * 2015-09-03 2019-08-28 Arizona Board of Regents on behalf of the University of Arizona LOW MOLECULAR DYRK1A INHIBITORS AND USES THEREOF
CA3019380A1 (en) 2016-03-31 2017-10-05 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CN109803962B (zh) 2016-09-30 2022-04-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调控蛋白的调节剂、以及药物组合物
MD3551622T2 (ro) 2016-12-09 2021-03-31 Vertex Pharma Modulator al regulatorului conductanței transmembranare în fibroză chistică, compoziții farmaceutice, metode de tratament și procedeu pentru fabricarea modulatorului
US9855255B1 (en) 2017-05-26 2018-01-02 King Saud University Substituted naphthyridinyl hydrazines as anti-liver cancer agents
US11253509B2 (en) 2017-06-08 2022-02-22 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
MA49631A (fr) 2017-07-17 2020-05-27 Vertex Pharma Méthodes de traitement de la fibrose kystique
JP7121794B2 (ja) 2017-08-02 2022-08-18 バーテックス ファーマシューティカルズ インコーポレイテッド ピロリジン化合物を調製するためのプロセス
WO2019079760A1 (en) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated CRYSTALLINE FORMS AND COMPOSITIONS OF CFTR MODULATORS
HRP20250272T1 (hr) 2017-10-19 2025-04-25 Teijin Pharma Limited Derivati benzimidazola i njihova uporaba
EP3720849A2 (en) 2017-12-08 2020-10-14 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
US12528810B2 (en) 2018-03-01 2026-01-20 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of DYRK/CLK and uses thereof
EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
WO2021096314A1 (ko) * 2019-11-15 2021-05-20 가천대학교 산학협력단 신규한 벤즈이미다졸 유도체 및 이의 용도
CN113491691B (zh) * 2020-04-02 2023-04-14 深圳贝瑞生物医药科技有限公司 一种用于制备抗肿瘤药物或14-3-3η蛋白抑制剂的化合物
KR102854745B1 (ko) * 2020-04-23 2025-09-04 진크래프트 주식회사 R-point 조절 단백질 복합체를 유효성분으로 포함하는 폐암 치료용 약학적 조성물, 상기 복합체의 형성 여부를 이용한 폐암 치료제 스크리닝 방법 및 폐암 진단 방법
WO2023241627A1 (en) * 2022-06-15 2023-12-21 Insilico Medicine Ip Limited Cdk8/19 dual inhibitors and methods of use thereof
IL318612A (en) 2022-07-29 2025-03-01 Ryvu Therapeutics S A Cancer treatment combination that includes a FLT3 inhibitor
WO2024023279A1 (en) 2022-07-29 2024-02-01 Ryvu Therapeutics S.A. Cancer combination therapy including a bcl-2 inhibitor
CN120826396A (zh) * 2023-03-06 2025-10-21 英矽智能科技(上海)有限公司 Cdk8/19双重抑制剂及其使用方法
CN120004808B (zh) * 2023-11-15 2025-11-25 宜昌人福药业有限责任公司 一种2-溴-5,6-二氯-1h-苯并咪唑的制备方法

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GB1122988A (en) * 1964-10-22 1968-08-07 Fisons Pest Control Ltd Benzimidazole derivatives
WO2003020698A2 (en) * 2001-09-06 2003-03-13 Prochon Biotech Ltd. Protein tyrosine kinase inhibitors

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CA2896156A1 (en) 2014-06-26
WO2014096388A2 (en) 2014-06-26
US9388192B2 (en) 2016-07-12
AU2013366513B2 (en) 2016-09-01
DK2935244T3 (en) 2018-09-10
HRP20181429T8 (hr) 2018-12-28
MX369589B (es) 2019-11-13
HUE039376T2 (hu) 2018-12-28
KR20150095908A (ko) 2015-08-21
WO2014096388A3 (en) 2014-08-21
PL2935244T3 (pl) 2019-02-28
BR112015014701B8 (pt) 2022-12-13
US20150336967A1 (en) 2015-11-26
SI2935244T1 (sl) 2019-01-31
GB201223265D0 (en) 2013-02-06
JP2016503779A (ja) 2016-02-08
RS57658B1 (sr) 2018-11-30
JP6169185B2 (ja) 2017-07-26
CA2896156C (en) 2018-05-22
ES2688395T3 (es) 2018-11-02
KR101779272B1 (ko) 2017-09-18
US20170152249A1 (en) 2017-06-01
AU2013366513A1 (en) 2015-06-11
PT2935244T (pt) 2018-10-22
LT2935244T (lt) 2018-10-25
EP2935244A2 (en) 2015-10-28
MX2015007057A (es) 2016-01-20
HRP20181429T1 (hr) 2018-11-30
IL239193A0 (en) 2015-07-30
CN104936951A (zh) 2015-09-23
SMT201800473T1 (it) 2018-11-09
EP2935244B1 (en) 2018-06-27
CY1120692T1 (el) 2019-12-11
US10174013B2 (en) 2019-01-08
BR112015014701B1 (pt) 2022-11-01

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