CN104936951B - 作为激酶抑制剂的苯并咪唑衍生物 - Google Patents

作为激酶抑制剂的苯并咪唑衍生物 Download PDF

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CN104936951B
CN104936951B CN201380067040.1A CN201380067040A CN104936951B CN 104936951 B CN104936951 B CN 104936951B CN 201380067040 A CN201380067040 A CN 201380067040A CN 104936951 B CN104936951 B CN 104936951B
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independently selected
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substituted
heterocycle
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CN104936951A (zh
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沃伊切赫·察尔迪邦
克日什托夫·布若佐卡
米夏尔·加莱佐夫斯基
雷娜塔·温达克
马里乌什·米利克
玛格达莱娜·扎瓦兹卡
帕维尔·古济克
埃韦利纳·温恰
玛尔塔·普罗科普
卡塔日娜·维克利克
亚历山德拉·萨比尼亚日
维斯瓦夫·马雷克·乔洛迪
雷蒙德·霍尔瓦特
托马斯·日姆斯基
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Ruiwu Treatment Co ltd
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Selvita Sp zoo
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380067040.1A 2012-12-21 2013-12-20 作为激酶抑制剂的苯并咪唑衍生物 Active CN104936951B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1223265.8 2012-12-21
GBGB1223265.8A GB201223265D0 (en) 2012-12-21 2012-12-21 Novel benzimidazole derivatives as kinase inhibitors
PCT/EP2013/077754 WO2014096388A2 (en) 2012-12-21 2013-12-20 Novel benzimidazole derivatives as kinase inhibitors

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CN104936951A CN104936951A (zh) 2015-09-23
CN104936951B true CN104936951B (zh) 2018-02-06

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US (2) US9388192B2 (OSRAM)
EP (1) EP2935244B1 (OSRAM)
JP (1) JP6169185B2 (OSRAM)
KR (1) KR101779272B1 (OSRAM)
CN (1) CN104936951B (OSRAM)
AU (1) AU2013366513B2 (OSRAM)
BR (1) BR112015014701B8 (OSRAM)
CA (1) CA2896156C (OSRAM)
CY (1) CY1120692T1 (OSRAM)
DK (1) DK2935244T3 (OSRAM)
ES (1) ES2688395T3 (OSRAM)
GB (1) GB201223265D0 (OSRAM)
HR (1) HRP20181429T8 (OSRAM)
HU (1) HUE039376T2 (OSRAM)
IL (1) IL239193A0 (OSRAM)
LT (1) LT2935244T (OSRAM)
MX (1) MX369589B (OSRAM)
PL (1) PL2935244T3 (OSRAM)
PT (1) PT2935244T (OSRAM)
RS (1) RS57658B1 (OSRAM)
SI (1) SI2935244T1 (OSRAM)
SM (1) SMT201800473T1 (OSRAM)
WO (1) WO2014096388A2 (OSRAM)

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GB201223265D0 (en) 2012-12-21 2013-02-06 Selvita Sa Novel benzimidazole derivatives as kinase inhibitors
WO2015108861A1 (en) 2014-01-14 2015-07-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US10202373B2 (en) 2014-01-14 2019-02-12 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
AU2015328174B2 (en) 2014-10-06 2020-05-21 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US10730842B2 (en) 2015-09-03 2020-08-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of DYRK1A and uses thereof
AU2017240685B2 (en) 2016-03-31 2021-08-12 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
JOP20190042B1 (ar) 2016-09-30 2021-08-17 Vertex Pharma مُعدِّل‏ لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل
JOP20190125B1 (ar) 2016-12-09 2022-03-14 Vertex Pharma مُعدِّل‏ لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل
US9855255B1 (en) 2017-05-26 2018-01-02 King Saud University Substituted naphthyridinyl hydrazines as anti-liver cancer agents
EP3634402A1 (en) 2017-06-08 2020-04-15 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
AU2018304168B2 (en) 2017-07-17 2023-05-04 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
US11434201B2 (en) 2017-08-02 2022-09-06 Vertex Pharmaceuticals Incorporated Processes for preparing pyrrolidine compounds
US10654829B2 (en) 2017-10-19 2020-05-19 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of CFTR modulators
KR102697255B1 (ko) 2017-10-19 2024-08-23 데이진 화-마 가부시키가이샤 벤즈이미다졸 유도체 및 이의 용도
CA3085006A1 (en) 2017-12-08 2019-06-13 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
WO2021096314A1 (ko) * 2019-11-15 2021-05-20 가천대학교 산학협력단 신규한 벤즈이미다졸 유도체 및 이의 용도
CN113491691B (zh) * 2020-04-02 2023-04-14 深圳贝瑞生物医药科技有限公司 一种用于制备抗肿瘤药物或14-3-3η蛋白抑制剂的化合物
KR102854745B1 (ko) 2020-04-23 2025-09-04 진크래프트 주식회사 R-point 조절 단백질 복합체를 유효성분으로 포함하는 폐암 치료용 약학적 조성물, 상기 복합체의 형성 여부를 이용한 폐암 치료제 스크리닝 방법 및 폐암 진단 방법
WO2023241627A1 (en) * 2022-06-15 2023-12-21 Insilico Medicine Ip Limited Cdk8/19 dual inhibitors and methods of use thereof
CN119816307A (zh) 2022-07-29 2025-04-11 雷沃医疗有限公司 包含flt3抑制剂的癌症组合疗法
CA3259243A1 (en) 2022-07-29 2024-02-01 Berlin-Chemie Ag CANCER POLYTHERAPY INCLUDING A BCL-2 INHIBITOR
AR132055A1 (es) * 2023-03-06 2025-05-21 Insilico Medicine Ip Ltd Inhibidores duales de cdk8/19 y métodos de uso de los mismos
CN120004808B (zh) * 2023-11-15 2025-11-25 宜昌人福药业有限责任公司 一种2-溴-5,6-二氯-1h-苯并咪唑的制备方法

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GB1122988A (en) * 1964-10-22 1968-08-07 Fisons Pest Control Ltd Benzimidazole derivatives
WO2003020698A2 (en) * 2001-09-06 2003-03-13 Prochon Biotech Ltd. Protein tyrosine kinase inhibitors

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BR112015014701A2 (pt) 2017-07-11
WO2014096388A2 (en) 2014-06-26
JP2016503779A (ja) 2016-02-08
IL239193A0 (en) 2015-07-30
DK2935244T3 (en) 2018-09-10
GB201223265D0 (en) 2013-02-06
KR101779272B1 (ko) 2017-09-18
US20150336967A1 (en) 2015-11-26
PT2935244T (pt) 2018-10-22
MX2015007057A (es) 2016-01-20
CA2896156A1 (en) 2014-06-26
BR112015014701B8 (pt) 2022-12-13
RS57658B1 (sr) 2018-11-30
JP6169185B2 (ja) 2017-07-26
US20170152249A1 (en) 2017-06-01
MX369589B (es) 2019-11-13
CY1120692T1 (el) 2019-12-11
PL2935244T3 (pl) 2019-02-28
HRP20181429T8 (hr) 2018-12-28
WO2014096388A3 (en) 2014-08-21
SI2935244T1 (sl) 2019-01-31
CA2896156C (en) 2018-05-22
US10174013B2 (en) 2019-01-08
AU2013366513A1 (en) 2015-06-11
KR20150095908A (ko) 2015-08-21
CN104936951A (zh) 2015-09-23
US9388192B2 (en) 2016-07-12
EP2935244A2 (en) 2015-10-28
EP2935244B1 (en) 2018-06-27
BR112015014701B1 (pt) 2022-11-01
AU2013366513B2 (en) 2016-09-01
ES2688395T3 (es) 2018-11-02
LT2935244T (lt) 2018-10-25
SMT201800473T1 (it) 2018-11-09
HRP20181429T1 (hr) 2018-11-30

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