CN104936600B - 孕甾-4-烯-20-炔-3-酮用于治疗抑郁症的用途 - Google Patents

孕甾-4-烯-20-炔-3-酮用于治疗抑郁症的用途 Download PDF

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CN104936600B
CN104936600B CN201380062351.9A CN201380062351A CN104936600B CN 104936600 B CN104936600 B CN 104936600B CN 201380062351 A CN201380062351 A CN 201380062351A CN 104936600 B CN104936600 B CN 104936600B
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alkynes
alkene
ketone
depression
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CN104936600A (zh
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路易斯·蒙蒂
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Pherin Corp
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Pherin Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380062351.9A 2012-12-28 2013-12-19 孕甾-4-烯-20-炔-3-酮用于治疗抑郁症的用途 Active CN104936600B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261747167P 2012-12-28 2012-12-28
US61/747,167 2012-12-28
PCT/US2013/076497 WO2014105620A1 (en) 2012-12-28 2013-12-19 Use of pregn-4-en-20-yn-3-one for the treatment of depressive disorders

Publications (2)

Publication Number Publication Date
CN104936600A CN104936600A (zh) 2015-09-23
CN104936600B true CN104936600B (zh) 2018-08-03

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CN201380062351.9A Active CN104936600B (zh) 2012-12-28 2013-12-19 孕甾-4-烯-20-炔-3-酮用于治疗抑郁症的用途

Country Status (11)

Country Link
US (1) US10322138B2 (https=)
EP (1) EP2938346B1 (https=)
JP (1) JP6283689B2 (https=)
KR (1) KR102209475B1 (https=)
CN (1) CN104936600B (https=)
AU (1) AU2013371025B2 (https=)
CA (1) CA2894686C (https=)
DK (1) DK2938346T3 (https=)
ES (1) ES2625778T3 (https=)
MX (1) MX369774B (https=)
WO (1) WO2014105620A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
JP7476229B2 (ja) * 2019-04-15 2024-04-30 フェリン・ファーマシューティカルズ・インコーポレイテッド 片頭痛の治療
KR20260032486A (ko) 2023-06-04 2026-03-09 비스타젠 쎄라퓨틱스, 인크. 정신운동 또는 인지 수행의 개선에 사용하기 위한 1,3,5(10),16-에스트라테트라엔-3-일 아세테이트
US20250312356A1 (en) * 2024-04-08 2025-10-09 Vistagen Therapeutics, Inc. Treatment of dysmenorrhea

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028904A1 (en) * 1993-06-15 1994-12-22 Pherin Corporation Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
CN1173181A (zh) * 1994-08-04 1998-02-11 弗伦有限公司 作为在下丘脑功能中发生改变的神经化学引发剂的孕甾烷和胆甾烷
US6057439A (en) * 1994-08-04 2000-05-02 Pherin Corporation Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5303703A (en) 1991-10-03 1994-04-19 Pherin Corporation Combined neuroepithelial sample delivery electrode device and methods of using same
US6331534B1 (en) 1994-08-04 2001-12-18 Pherin Pharmaceuticals, Inc. Steroids as neurochemical stimulators of the VNO to alleviate pain
US5563131A (en) * 1994-08-04 1996-10-08 Pherin Corporation Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US6117860A (en) 1994-08-04 2000-09-12 Pherin Pharmaceuticals, Inc. Steroids as neurochemical stimulators of the VNO to treat paroxistic tachycardia
US6066627A (en) 1994-08-04 2000-05-23 Pherin Corporation Steroids as neurochemical initiators of change in human blood levels of LH
PL331357A1 (en) * 1996-07-23 1999-07-05 Pherin Pharmaceuticals Steroids as neurochemical vno stimulators for soothing the symptoms of premenstrual tension and anxiety
US20020123138A1 (en) * 2000-11-30 2002-09-05 Jian Zhang Human VNO receptor (R1)
US20030045514A1 (en) 2001-05-03 2003-03-06 Louis Monti 17-Methyleneandrostan-3alpha-ol analogs as CRH inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028904A1 (en) * 1993-06-15 1994-12-22 Pherin Corporation Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
CN1173181A (zh) * 1994-08-04 1998-02-11 弗伦有限公司 作为在下丘脑功能中发生改变的神经化学引发剂的孕甾烷和胆甾烷
US6057439A (en) * 1994-08-04 2000-05-02 Pherin Corporation Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety

Also Published As

Publication number Publication date
ES2625778T3 (es) 2017-07-20
US20140187524A1 (en) 2014-07-03
EP2938346B1 (en) 2017-04-05
DK2938346T3 (en) 2017-06-12
CA2894686A1 (en) 2014-07-03
HK1210421A1 (en) 2016-04-22
WO2014105620A1 (en) 2014-07-03
KR20150100884A (ko) 2015-09-02
AU2013371025B2 (en) 2018-01-18
CA2894686C (en) 2021-05-04
JP6283689B2 (ja) 2018-02-21
KR102209475B1 (ko) 2021-01-28
MX369774B (es) 2019-11-21
AU2013371025A1 (en) 2015-07-09
EP2938346A1 (en) 2015-11-04
CN104936600A (zh) 2015-09-23
MX2015008454A (es) 2016-05-16
US10322138B2 (en) 2019-06-18
JP2016504361A (ja) 2016-02-12

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