CN1049342C - Chinese medicine preparation for tranquilization and preparing process thereof - Google Patents
Chinese medicine preparation for tranquilization and preparing process thereof Download PDFInfo
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- CN1049342C CN1049342C CN93111083A CN93111083A CN1049342C CN 1049342 C CN1049342 C CN 1049342C CN 93111083 A CN93111083 A CN 93111083A CN 93111083 A CN93111083 A CN 93111083A CN 1049342 C CN1049342 C CN 1049342C
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Abstract
The present invention relates to a traditional Chinese medicine preparation for warming the gallbladder and tranquilizing, which is prepared from the following ingredients: coptis, spine date seed, pinellia tuber, pummelo peel, immature orange fruit, tuckahoe, angelica, common anemarrhena rhizome, Chinese magnolivine fruit, grassleaf sweetflag rhizome, hemlock parsley, radix glycyrrhiza, calcium carbonate and starch. The prescription is established according to clinical experience for years, the etiology and pathogenesis of insomnia and prescription principles of traditional Chinese medicine theory. Therefore, the present invention has obvious curative effects on sleepless diseases, such as insomnia, neurosis, etc. Conditions for taking medicine are obviously improved, and the present invention has the advantages of simple preparation method, small taking dose, convenience, stable and obvious curative effect and no toxic or side effect.
Description
The present invention relates to a kind of Traditional Chinese medicine for tranquilization preparation and preparation method thereof.This Chinese medicine preparation is used for the treatment of insomnia, neurosis.
At present, the insomnia, the neurosis that cause because of diseases caused by exogenous pathogenic factor or internal injury, as neurasthenia, anxiety neurosis, hysteria etc., that is traditional Chinese medical science what is called " is insomnia ", comparatively sees more.The various sedative hypnotic of the normal employing of general Therapeutic Method are as chemical synthetic drug and Chinese medicine decoction etc.As the bromide of tranquilizer, be eliminated already because of easily putting aside in vivo to poison.The chlordiazepoxide that replaces (chlorine nitrogen), stable (benzene first phenodiazine) etc., though the genus minor tranquilizer has been taken addiction and side effect for a long time, xerostomia, loss of appetite, dizziness, ataxia, reaction such as drowsiness are arranged, can disappear after the decrement, large dose oral administration can cause granulocytopenia.And Chinese medicine decoction is because of decocting trouble, and taking dose is big inconvenient and have uncomfortable mouthfeel, curative effect also unstable, applies so influence it.
The purpose of this invention is to provide a kind of Traditional Chinese medicine for tranquilization preparation and preparation method thereof, it not only obviously improves the condition of taking medicine, preparation method is easy, taking dose is little, convenient but also stable curative effect, remarkable, without any side effects.
Purpose of the present invention realizes like this: this Chinese medicine preparation is with 3～5 parts of Rhizoma Coptidis, and 2～7 parts of 4～7 parts of Semen Ziziphi Spinosaes, 3～5 parts of Rhizoma Pinelliae, 6～10 parts of Exocarpium Citri Grandises, 6～10 parts of Fructus Aurantii Immaturuss, 6～10 parts in Poria, 4～7 parts of Radix Angelicae Sinensis, 4～8 parts of the Rhizoma Anemarrhenaes, 2～5 parts of Fructus Schisandrae Chinensis, 5～7 parts of Rhizoma Acori Graminei, 4～9 parts of Rhizoma Chuanxiongs, 3～6 parts in Radix Glycyrrhizae, 2～5 parts of calcium carbonate, starch are made for raw material.
The preparation method of this Chinese medicine preparation: at first by measuring 3～5 parts of Rhizoma Coptidis, 4～7 parts of Semen Ziziphi Spinosaes, 3～5 parts of Rhizoma Pinelliae, 6～10 parts of Exocarpium Citri Grandises, 6～10 parts of Fructus Aurantii Immaturuss, 6～10 parts in Poria, 4～7 parts of Radix Angelicae Sinensis, 4～8 parts of the Rhizoma Anemarrhenaes, 2～5 parts of Fructus Schisandrae Chinensis, 5～7 parts of Rhizoma Acori Graminei, 4～9 parts of Rhizoma Chuanxiongs, 3～6 parts in Radix Glycyrrhizae, 2～5 parts of calcium carbonate, 2～7 parts of starch.With pericarpium citri grandis, Fructus Aurantii Immaturus, Rhizoma Acori Graminei, Rhizoma Chuanxiong, when woman, Fructus Schisandrae Chinensis Six-element medicine place container, add 5～10 times of water of Six-element medicine total amount, 10～30 ℃ soak 3～12 hours after, extract volatile oil with the way of distillation, carry most back and divide and get volatile oil and seal up for safekeeping standby; Rhizoma Coptidis, Rhizoma Pinelliae Semen Ziziphi Spinosae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae five kinds of Chinese medicine are placed extraction pot.After soaking by above-mentioned condition, merge with the medicinal residues of carrying most volatile oil and water liquid again, decoct according to a conventional method three times, each 30～120 minutes, merge three decoction liquor, filtration, becoming relative density at 30～120 ℃ of following concentrating under reduced pressure is 1.2～1.4 thick paste; With the Poria roguing, crushing screening is standby; Poria, the thick paste mixing of half of getting calcium carbonate quantity and preparation, put 70～120 ℃ down oven dry get dry extract, crushing screening, extract dry powder; Get second half calcium carbonate and put in the lapping-in device and add volatile oil, grinding the even volatile oil of making that is mixed and disperseing thing, extract dry powder, the volatile oil of preparation is disperseed thing and starch mixing, make the powder that contains extractum.
With make the powder that contains extractum divide encapsulated in, make capsule.
Add its total amount 5～8% starch slurries or concentration 40～70% ethanol with making the powder that contains extractum, granulate,, make granule 60～90 ℃ of dryings.
Add its total amount 2～5% hydroxypropyl celluloses with making the powder that contains extractum, 5～8% starch slurries or concentration 40～80% ethanol, granulate, dry under 60～90 ℃, dry back adds dry granular total amount 1～2% hydroxypropyl cellulose, 1～2% Pulvis Talci, 0.5～2% magnesium stearate, tabletting is used the acrylic resin coating, makes coated tablet.
Because the prescription of Chinese medicine preparation of the present invention constitutes, it is basis clinical experience for many years, at the etiology and pathogenesis of being insomnia, formulate by the traditional Chinese medical science principle-method-recipe-medicines principles of formulating prescriptions, so should be square through the science compatibility, clear away heart-fire, vent one's spleen in line with reducing phlegm dissipating depression of QI, nourishing blood to tranquillize the mind is the treatment criterion, so the disease of being insomnia such as Cure for insomnia, neurosis is had produce effects.Use pericarpium citri grandis, Poria, Fructus Aurantii Immaturus, Rhizoma Coptidis with eliminating phlegm and lowering adverse QI among this side, the relieving restlessness of relieving inflammation or internal heat; With nourishing blood to tranquillize the mind, the convergence motive, join Rhizoma Coptidis with the clear away heart-fire merit of relieving restlessness of enhancing with Radix Angelicae Sinensis, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis with the Rhizoma Anemarrhenae; With the Rhizoma Acori Graminei resuscitation inducing and mind tranquilizing; The Rhizoma Chuanxiong activating QI to alleviate the depression dispels the wind and end headache, and it is up to draw all medicines; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription share all medicines, the effect that playing altogether reduces phlegm clears away heart-fire, dissipating depression of QI is calmed the nerves.The preparation method of this pure Chinese medicinal preparation is easy, cost is low, and manufactured goods the experiment proved that stable curative effect, remarkable.Its drug effect and toxicological experiment result are as follows:
Pharmacological evaluation proves that the pharmacy preparation has the obvious suppression effect to the mice autonomic activities among the present invention, oral low dose (1.25g/kg) p＜0.05; In oral, heavy dose of (2.50g/kg, 5.00g/kg) p＜0.01.Sleep has the obvious prolongation effect (p＜0.01) of the length of one's sleep to the mice sodium pentobarbital.The mouse movement reinforcement that causes with coffee of anhydrating there is obvious suppression effect (p＜0.01).There is remarkable anti-semicarbazides to bring out the effect of fainting of throbbing with fear (p＜0.001) to mice.Illustrate that to sum up this Chinese medicine preparation has stronger system to press down effect to nervus centralis, for diseases such as clinical treatment mind uneasiness, insomnia, dreaming often and waking easily provide the pharmacology foundation.
Drug effect contrast experiment: Chinese medicine preparation of the present invention compares with stable, and heavy dose of (5kg/kg) mice autonomic activities inhibitory action is better than stabilizing (0.1g/kg), and middle dosage (2.5g/kg) is close with stable (0.1g/kg).Pure Chinese medicinal preparation reaches above-mentioned curative effect and still belongs to rarely, and toxicity is very low, without any side effects, also be Western medicine can't be obtained.
Long term toxicity test: continuous 8 weeks of Chinese medicine preparation of the present invention gavage 10.63g, 1.25g, 2.5g/kg greatly for Mus), be equivalent to respectively to be grown up 15,30 and 60 times an of consumption per day all do not have tangible accumulate poisoning reaction to the growth promoter of rat, blood system, hepatic and renal function etc.Though the bent thin urinary catheter epithelial cell of kidney of rats is had certain damage, but after drug withdrawal observed for 3 weeks, proves that the damage to kidney can recover, have no side effect.
Acute toxicity testing: Chinese medicine preparation of the present invention abdominal cavity is 19.01 ± 0.0902g/kg (95% average fiducial limit) to Chinese medicine to the median lethal dose(LD 50) (LD50) of mice.To mouse gavaging maximum tolerated dose every day is 32g/kg, for the adult measures 800 times, the performance activity reduces, quiet, do not have other abnormal finding, illustrate that its toxicity is very little, take safe and reliable effectively.
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
Take by weighing Rhizoma Coptidis 40g, Semen Ziziphi Spinosae 60g, Rhizoma Pinelliae 40g, pericarpium citri grandis 80g, Fructus Aurantii Immaturus 80g, Radix Angelicae Sinensis 60g, Rhizoma Anemarrhenae 60g, Fructus Schisandrae Chinensis 40g, Rhizoma Acori Graminei 60g, Rhizoma Chuanxiong 60g, Radix Glycyrrhizae 40g, calcium carbonate 30g, starch 40g by recipe quantity.
Earlier pericarpium citri grandis, Fructus Aurantii Immaturus, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Schisandrae Chinensis Six-element medicine are placed container, add 8 times of water of Six-element medicine total amount, soaked 6 hours down, extract volatile oil, carry most back and divide and get volatile oil and seal up for safekeeping standby with the way of distillation at 10～30 ℃.
Rhizoma Coptidis, Rhizoma Pinelliae, Semen Ziziphi Spinosae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae five kinds of Chinese medicine are placed extraction pot, add 8 times of water of five kinds of Chinese medicine total amount, after soaking 12 hours under 10～30 ℃, merge with above-mentioned medicinal residues and the water liquid of carrying most volatile oil again, decoct each 40 minutes according to a conventional method three times.Merge the decoction liquor extracted for three times, filtration, be condensed into thick paste (50 ℃ time relative density be 1.30～1.35) at 70～100 ℃ of following reduction vaporizations.
With Fu make roguing, to pulverize 80 mesh sieves standby.
Calcium carbonate is divided equally two parts.With the Fu order of wherein portion and preparation, thick paste mixing, put 100～120 ℃ of oven dry down, get dry extract, pulverized 80 mesh sieves, extract dry powder.
Another part calcium carbonate put in the lapping-in device add above-mentioned volatile oil and grind the even volatile oil of making that is mixed and disperse thing.
Extract dry powder, the volatile oil of preparation are disperseed thing, starch mixing, make the powder that contains extractum.
The powder that will contain extractum divide encapsulated in, every 0.3～0.35g obeys 2～3 at every turn, every day 2～3 times.
The powder that will contain extractum adds 5～8 times of ethanol of its total amount, granulates, and takes after 80～90 ℃ of following dryings are made suspension, also the available water clothes.Each 2～3 bags, every day 2～3 times.
The powder that will contain extractum adds its total amount 2～5% hydroxypropyl celluloses, 1～2% Pulvis Talci, 0.5～2% magnesium stearate, tabletting, and every 0.35g uses the acrylic resin coating, makes coated tablet.2～3 of each clothes, every day 2～3 times.
Embodiment 2:
Take by weighing Rhizoma Coptidis 30g, Semen Ziziphi Spinosae 40g, Rhizoma Pinelliae 50g, pericarpium citri grandis 90g, Fructus Aurantii Immaturus 60g, Poria 90g, Radix Angelicae Sinensis 40g, Rhizoma Anemarrhenae 80g, Fructus Schisandrae Chinensis 20g, Rhizoma Acori Graminei 50g, Rhizoma Chuanxiong 40g, Radix Glycyrrhizae 30g, calcium carbonate 40g, starch 30g by recipe quantity
All the other preparation process are with embodiment 1.
Embodiment 3:
Take by weighing Rhizoma Coptidis 50g, Semen Ziziphi Spinosae 70g, Rhizoma Pinelliae 30g, pericarpium citri grandis 60g, Fructus Aurantii Immaturus 100g, Poria 60g, Radix Angelicae Sinensis 70g, Rhizoma Anemarrhenae 40g, Fructus Schisandrae Chinensis 50g, Rhizoma Acori Graminei 70g, Rhizoma Chuanxiong 90g, Radix Glycyrrhizae 60g, calcium carbonate 50g, starch 20g by recipe quantity
All the other preparation process are with embodiment 1.
Claims (5)
1, a kind of Traditional Chinese medicine for tranquilization preparation, it is characterized in that with 3～5 parts of Rhizoma Coptidis 2～7 parts of 4～7 parts of Semen Ziziphi Spinosaes, 3～5 parts of Rhizoma Pinelliae, 6～10 parts of Exocarpium Citri Grandises, 6～10 parts of Fructus Aurantii Immaturuss, 6～10 parts in Poria, 4～7 parts of Radix Angelicae Sinensis, 4～8 parts of the Rhizoma Anemarrhenaes, 2～5 parts of Fructus Schisandrae Chinensis, 5～7 parts of Rhizoma Acori Graminei, 4～9 parts of Rhizoma Chuanxiongs, 3～6 parts in Radix Glycyrrhizae, 2～5 parts of calcium carbonate, starch are made for raw material.
2, a kind of preparation method of Traditional Chinese medicine for tranquilization preparation is characterized in that at first by measuring 3～5 parts of Rhizoma Coptidis, 4～7 parts of Semen Ziziphi Spinosaes, 3～5 parts of Rhizoma Pinelliae, 6～10 parts of Exocarpium Citri Grandises, 6～10 parts of Fructus Aurantii Immaturuss, 6～10 parts in Poria, 4～7 parts of Radix Angelicae Sinensis, 4～8 parts of the Rhizoma Anemarrhenaes, 2～5 parts of Fructus Schisandrae Chinensis, 5～7 parts of Rhizoma Acori Graminei, 4～9 parts of Rhizoma Chuanxiongs, 3～6 parts in Radix Glycyrrhizae, 2～5 parts of calcium carbonate, 2～7 parts of starch; Exocarpium Citri Grandis, Fructus Aurantii Immaturus, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Schisandrae Chinensis Six-element medicine are placed container, add 5～10 times of water of Six-element medicine total amount, 10～30 ℃ soak 3～12 hours after, extract volatile oil with the way of distillation, carry most back and divide and get volatile oil and seal up for safekeeping standby; Rhizoma Coptidis, Rhizoma Pinelliae, Semen Ziziphi Spinosae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae five kinds of Chinese medicine are placed extraction pot, after above-mentioned condition immersion, merge with the medicinal residues of carrying most volatile oil and water liquid again, decoct according to a conventional method three times, each 30～120 minutes, merge three decoction liquor, filtration, becoming relative density at 30～120 ℃ of following concentrating under reduced pressure is 1.2～1.4 thick paste; With the Poria roguing, crushing screening is standby; Poria, the thick paste mixing of half of getting calcium carbonate quantity and preparation, put 70～120 ℃ down oven dry get dry extract, crushing screening, extract dry powder; Get second half calcium carbonate and put in the lapping-in device and add volatile oil, grinding the even volatile oil of making that is mixed and disperseing thing; Extract dry powder, the volatile oil of preparation are disperseed thing and starch mixing, make the powder that contains extractum.
3, method according to claim 2, it is characterized in that with make the powder that contains extractum divide encapsulated in, make capsule.
4, method according to claim 2 is characterized in that adding its total amount 5～8% starch slurries or concentration 40～70% ethanol with making the powder that contains extractum, granulates, and 60～90 ℃ of dryings, makes granule.
5, method according to claim 2, it is characterized in that to make the powder that contains extractum and add its total amount 2～5% hydroxypropyl celluloses, 5～8% starch slurries or concentration 40～80% ethanol are granulated, and are dry down at 60～90 ℃, dry back adds dry granular total amount 1～2% hydroxypropyl cellulose, 1～2% Pulvis Talci, 0.5～2% magnesium stearate, tabletting, use the acrylic resin coating, make coated tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111083A CN1049342C (en) | 1993-04-27 | 1993-04-27 | Chinese medicine preparation for tranquilization and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111083A CN1049342C (en) | 1993-04-27 | 1993-04-27 | Chinese medicine preparation for tranquilization and preparing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1080187A CN1080187A (en) | 1994-01-05 |
| CN1049342C true CN1049342C (en) | 2000-02-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93111083A Expired - Fee Related CN1049342C (en) | 1993-04-27 | 1993-04-27 | Chinese medicine preparation for tranquilization and preparing process thereof |
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| CN (1) | CN1049342C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062477C (en) * | 1997-12-30 | 2001-02-28 | 郝永成 | Traditional Chinese medicine for treating vegetative nerve functional disturbance |
| CN1056308C (en) * | 1998-03-24 | 2000-09-13 | 郝永成 | Medicine for adjusting cranial nerve function |
| CN110742977A (en) * | 2019-12-02 | 2020-02-04 | 无锡问安生物科技有限公司 | Traditional Chinese medicine powder for treating insomnia |
| CN115444915A (en) * | 2022-09-20 | 2022-12-09 | 山东中医药大学 | Traditional Chinese medicine composition for treating insomnia and preparation method and application thereof |
-
1993
- 1993-04-27 CN CN93111083A patent/CN1049342C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 中医名方应用进展(第一版) 1991.4.1 魏菊仙等，中国医药科技出版社 * |
| 方剂学第一版 1985.6.1 许济群等，上海科学技术出版社 * |
| 方剂学第一版 1985.6.1 许济群等，上海科学技术出版社;中医名方应用进展(第一版) 1991.4.1 魏菊仙等，中国医药科技出版社 * |
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| Publication number | Publication date |
|---|---|
| CN1080187A (en) | 1994-01-05 |
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