CN1049340C - Xiaojianwan pill for eliminating hard masses - Google Patents

Abstract

The present invention relates to a pill for eliminating hard masses, which belongs to medicine. The pill of the present invention has certain curative effect for treating various tumors, and has ideal curative effect on gynecologic hyperplasia of mammary gland, fibroadenoma of breast, and intracanalicular papilloma. The formula of the present invention comprises the following main components: asparagus with an antitumor function, antelope horn(powder) and alkanna tinctoria; in order to reinforce the functions of eliminating tumors, dispersing masses and inhibiting tumors, zedoary roots, (system) rhizoma arisaematis and green tangerine peel which is used for soothing livers, regulating qi, dispersing masses and eliminating sputum are added into the pill. After being mixed and milled, the components are sieved by a sieve with 120 meshes to prepare a watered pill.

Description

A kind of medicine for the treatment of mastopathy

The present invention relates to a kind of compositions for the treatment of mastopathy, particularly be to be the Chinese patent medicine of feedstock production with the vegetable Chinese herbal medicine.

" motherland's medical science " is thought, is caused that " lump in breast " reason mostly is depression of liver-QI, horizontal gram spleen soil, the dysfunction of the spleen, retention of water-damp, the poly-expectorant that forms; Stagnation of liver-QI for a long time fire-transformation, decocts phlegm-damp and forms disease nuclear, pents up in breast then to be lump in breast.Being used for the treatment of mastotic medicine now, " RUPIXIAO ", " RUKANG PIAN ", " asparagine sheet " are arranged all is to be used for the treatment of cystic hyperplasia of breast (being cyclomastopathy), at period in a medicine, lump in breast generally can both dwindle or complete obiteration in deliquescing, in case but drug withdrawal, its lump in breast also can recur.And treatment mammary gland fibrous tumours, intracanalicular papilloma are of no curative effect, and at present, the Therapeutic Method that general treatment mammary gland fibroma and intracanalicular papilloma adopt is excision, is easy to damage breast duct in the operation, easily brings out mastitis in age of sucking.Some patient is behind total surgical resection, and often because tumor resection is not thorough, thereby the tumor locus after causing excising grows new tumor again.

The object of the present invention is to provide a kind of medicine for the treatment of mastopathy, this medicine especially has optimal curative effect to treatment gynecological cystic hyperplasia of breast, mammary gland fibroadenoma and intracanalicular papilloma.

The present invention's key component of filling a prescription is: Radix Asparagi, Cornu Caprae seu Ovis, Radix Arnebiae (Radix Lithospermi), for strengthening dispersing swelling and dissipating binds, suppressing tumor, can add Rhizoma Curcumae, Rhizoma Arisaematis, and it is formulated also can to add the Pericarpium Citri Reticulatae Viride that is used for depressed liver-energy dispersing and QI regulating, eliminating stagnation expectorant.Its percentages of ingredients content is: Radix Asparagi 34-60%, Cornu Caprae seu Ovis 15-50%, Radix Arnebiae (Radix Lithospermi) 15-50%; Additive is: Rhizoma Curcumae 12-25%, Rhizoma Arisaematis 12-25%, Pericarpium Citri Reticulatae Viride 12-15%.Also satisfy each component sum and equal 100%.

Component that will be above-mentioned is worn into smalls after mixing, and behind 120 mesh sieves, makes the watered pill by the conventional manufacture method of making the watered pill excessively.

Method of administration: for oral administration, boiled water one time 10 gram of taking after mixing it with water, three times on the one.

The course of treatment: one month is a course of treatment.

Taboo: prohibit peppery, anemia of pregnant woman and prohibit clothes, the careful clothes of menstrual phase.

The present invention's prescription is to develop its major function according to the pathogeny of " motherland's medical science " cystic hyperplasia of breast: heat-clearing and toxic substances removing, dissipation sucutaneous nodule nuclear, promoting the circulation of QI to relieve pain.

Radix Asparagi antitumor action, its root contain big DIGEN element, phlegmatic temperament, and β _ paddy stays alcohol and methoxy alditol.Contained bitter principle is made up of chinaroot greenbrier sapogenin, rhamnose, xylose and Fructus Vitis viniferae for staying the body Saponin.It has certain inhibitory action to acute lymphoblastic type leukemia, chronic myelocytic leukemia and the leukocytic dehydrogenase of acute monocyte type leukaemic, and can suppress the leukocytic breathing of acute lymphoblastic type leukaemic.

The Cornu Caprae seu Ovis antitumor action, behind the white mice inoculation ehrlich carcinoma three days, to irritate stomach and give continuous Cornu Saigae Tataricae 100% decoct, 0.1 milliliter/10 gram/days or mix in feedstuff by 5% concentration, around the, the former presses the tumor volume calculation after the administration, and its suppression ratio is 79.69%; By the tumor re-computation, its suppression ratio is that 75.43% ， Cornu Caprae seu Ovis mixes in feedstuff, and by the tumor re-computation, its suppression ratio is 75.43%; By the tumor volume calculation, its suppression ratio is 46.24%, and by the tumor re-computation, its suppression ratio is 31.65%, and it is good that administration by gavage is sneaked into the feedstuff tumor killing effect.

Radix Arnebiae (Radix Lithospermi) antitumor action, its root contain the pale reddish brown quinone of pale reddish brown quinone β 1 β, the one dimethyl allene acyl of acetyl, the β _ pale reddish brown quinone of antelope base isovaleryl, the 3.4 1 dimethyl pentenes-pale reddish brown quinone of 3-acyl group.It has certain curative effect to chorionic epithelioma and malignant mole.With methylene blue test tube method primary dcreening operation.Radix Arnebiae (Radix Lithospermi) has extremely slight inhibitory action to acute lymphoblastic leukemia.The sickness rate of the spontaneous breast carcinoma of pale reddish brown minimizing the (Mus).Oxicity analysis: with Yunnan pale reddish brown syrup 5-15 gram/kilogram feeding mice two months, general appetite is with movable normal, body weight changes not obvious, pathological anatomy is except that hypophysis, ovary, uterus weight alleviate, other all do not have change as thyroid, adrenal weight, at test under microscope, the tissue of looking into is not all observed structural pathological change.The pale reddish brown pharmaceutical chemistry feeding mice in 30% Xinjiang loses weight about 30% in 1 week, in 15 days 40% death is arranged; Irritate stomach with root powder 5 gram/kilograms to rabbit, urine color depth purple albumen and erythrocyte occur, and diarrhoea is arranged after 3 days in the urine, and drug withdrawal is transference cure after 2 days.

The Rhizoma Curcumae rhizome contains volatile oil 1-1.5%, and main component is a sesquiterpene in the oil.The sesquiterpene of getting from rhizome has zederone, Rhizoma Curcumae three ketone, Rhizoma Curcumae cyclic diolefine, curzerene, Rhizoma Curcumae ring two rare ketone, different Rhizoma Curcumae ring two rare ketone, the rare ketone of Rhizoma Curcumae, table Rhizoma Curcumae ketenes, curdiono, curcolone, Rhizoma Curcumae Longae epoxy enol difficult to understand, procurcumenol, different Rhizoma Curcumae Longae epoxy enol difficult to understand, curcumadiol.Also contain the curcumin dehydrocurdione.Dried root starch-containing 64%.Oral and lumbar injection Rhizoma Curcumae, injection has inhibitory action to murine sarcoma-180, but oral then invalid to the mice ehrlich carcinoma.

The Rhizoma Arisaematis tuber contains triterpenoid saponin, benzoic acid, starch, aminoacid.During the test of aqueous extract (cryoconcentration adds ethanol and precipitates, and gets supernatant concentration and makes) test tube, 1: 8-1: during 32 concentration the HeIa cell is had inhibitory action, cell condenses into bulk, forfeiture normal cell structure, part cell detachment.The mouse experiment tumor is comprised sarcoma--180HCA (hepatocarcinoma), solid type, U ₁₄(transplanting in the mice person for squamous epithelial cancer type cervical cancer), 0.1 milliliter/of intramuscular injection every day aqueous extract has tangible tumor-inhibiting action.From bright Rhizoma Arisaematis, carry crystallization D-manna same tumor-inhibiting action is arranged, but very unobvious to the HeIa cell inhibiting.Oxicity analysis: the Rhizoma Arisaematis rhizome has been eaten intensive system raw and has been swashed effect, oral mucosa is slightly rotten to the corn, even partial necrosis comes off, the smoke uptake drying, and burn feeling, tongue body enlargement, lip edema, a large amount of sialorrhea, dispute numbness, gustatory anesthesia, hoarseness arranged, difficulty in opening mouth, mouse peritoneal injection Japanese water immersion median lethal dose(LD 50) is 13.5 gram/kilograms.

Pericarpium Citri Reticulatae Viride contains volatile oil, and contains flavonoid glycoside etc. more.

Prescription drug function of the present invention: Radix Asparagi is gone into the lung kidney channel, and its function YIN nourishing profit is made an uproar, the lung heat clearing pathogenic fire reducing; Cornu Caprae seu Ovis is gone into liver heart channel, and the function heat clearing away is relieving convulsion, make eye bright, detoxify; Radix Arnebiae (Radix Lithospermi) goes into the pericardium channel Liver Channel, the function removing heat from blood, invigorate blood circulation, heat-clearing and toxic substances removing; Rhizoma Curcumae is gone into the liver spleen channel, function circulation of qi promoting, removing blood stasis, removing food stagnancy, relieves the pain; Rhizoma Arisaematis is gone into lung liver spleen channel, function: drying dampness to eliminate phlegm, remove wind arresting convulsion, dispersing swelling and dissipating binds; Pericarpium Citri Reticulatae Viride is gone into the liver and gall warp, function: soothing the liver dispelling the stagnated QI, eliminating stagnation expectorant.

The present invention provides following examples:

Embodiment 1:

The component degree

Radix Asparagi 34%

Cornu Caprae seu Ovis 15%

Radix Arnebiae (Radix Lithospermi) 15%

Rhizoma Arisaematis 12%

Rhizoma Curcumae 12%

Pericarpium Citri Reticulatae Viride 12%

Embodiment 2:

The component degree

Radix Asparagi 50%

Cornu Caprae seu Ovis 25%

Radix Arnebiae (Radix Lithospermi) 25%

Embodiment 3:

The component degree

Radix Asparagi 36%

Cornu Caprae seu Ovis 18%

Radix Arnebiae (Radix Lithospermi) 18%

Rhizoma Arisaematis 14%

Rhizoma Curcumae 14%

Embodiment 4:

The component degree

Radix Asparagi 35%

Cornu Caprae seu Ovis 25%

Radix Arnebiae (Radix Lithospermi) 25%

Pericarpium Citri Reticulatae Viride 15%

Prescription of the present invention is through repetition test repeatedly, through the treatment of clinical system observation for many years, it has good especially effect to treatment mammary gland hypertrophy disease, mammary gland fibroadenoma, intracanalicular papilloma, and curative effect is short, all can cure general one to four course of treatment, and do not find toxic and side effects and anaphylaxis.

Model case:

1, the palace * *, woman, 35 years old, peasant, Yanshi, Henan Province county Jiu Xian people from village.Married, give birth to 1 man, 1 woman.Examine in June, 1989: the bimastism painful lump 2 years mixed that expands is surplus, the premenstrua mammary swelling is painful to be increased the weight of, hospital of a few family is diagnosed as " cystic hyperplasia of breast " through the Luoyang City, with medicines such as " RUPIXIAO ", " asparagine " unite take nearly 1 year surplus, unsatisfactory curative effect.Existing disease is seen: resemble on bimastism is outer lump about 5 * 7 (centimetre) ², matter is hard, and clear-cut margin does not have adhesion with surrounding tissue and pectoralis major, and the pain of laying one's hand on is examined and is cystic hyperplasia of breast.Medication " Xiaojianwan pill for eliminating hard masses ", each oral 10 grams, are taken 2 recoveries from illness course of treatment at every day 3 times.Follow up a case by regular visits to not recurrence again in 5 years.

2, Zhai * *, the woman, 25 years old, married, give birth to 1 boy, Xian Dakou township, Yanshi, Henan Province Jiao rears people.JIUYUE was examined on the 23rd in one nine eight seven years: right nipple resembles about 6 centimeters outward, have a lump 3 years surplus, three institute's oncologies are examined and are " mammary gland fibroadenoma " through the Luoyang City, fear operation, come diagnosis and treatment, disease is seen: lump is rounded, diameter about 3 * 3 (centimetre) ², matter is hard, and smooth surface does not have adhesion with surrounding tissue and pectoralis major, and mobility is good, examines to be mammary gland fibroadenoma.The medication Xiaojianwan pill for eliminating hard masses, each oral 10 grams are taken a course of treatment every day 3 times, and lump disappears, and patient adheres to again taking a course of treatment because of fearing recurrence, fully recovers and withdraws.With examining not recurrence again in 5 years.

Claims (5)

1, a kind of medicine for the treatment of mastopathy, it is characterized in that: its component and weight percentage thereof are:

Radix Asparagi 34% Cornu Caprae seu Ovis 15%

Radix Arnebiae (Radix Lithospermi) 15% Rhizoma Arisaematis 12%

Rhizoma Curcumae 12% Pericarpium Citri Reticulatae Viride 12%.

2, a kind of medicine for the treatment of mastopathy, it is characterized in that: its component and weight percentage thereof are:

Radix Asparagi 50%

Cornu Caprae seu Ovis 25%

Radix Arnebiae (Radix Lithospermi) 25%.

3, a kind of medicine for the treatment of mastopathy, it is characterized in that: its component and weight percentage thereof are:

Radix Asparagi 36% Cornu Caprae seu Ovis 18%

Radix Arnebiae (Radix Lithospermi) 18% Rhizoma Arisaematis 14%

Rhizoma Curcumae 14%.

4, a kind of medicine for the treatment of mastopathy, it is characterized in that: its component and weight percentage thereof are:

Radix Asparagi 35% Cornu Caprae seu Ovis 25%

Radix Arnebiae (Radix Lithospermi) 25% Pericarpium Citri Reticulatae Viride 15%.

5, according to arbitrary described medicine among the claim 1-4, it is characterized in that: it is a kind of pill.