CN104926835B - 一种盐酸头孢替安化合物、其制备方法及其药物组合物 - Google Patents
一种盐酸头孢替安化合物、其制备方法及其药物组合物 Download PDFInfo
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- CN104926835B CN104926835B CN201510351054.7A CN201510351054A CN104926835B CN 104926835 B CN104926835 B CN 104926835B CN 201510351054 A CN201510351054 A CN 201510351054A CN 104926835 B CN104926835 B CN 104926835B
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- cefotiam hydrochloride
- cefotiam
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
批次 | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 |
θ(°) | 35 | 37 | 36 | 34 | 33 | 32 | 34.5 |
盐酸头孢替安 | 混合度 |
本发明实施例1 | 0.23 |
CN102659818A | 0.81 |
CN103232477A | 0.73 |
Claims (9)
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CN201510351054.7A CN104926835B (zh) | 2015-06-24 | 2015-06-24 | 一种盐酸头孢替安化合物、其制备方法及其药物组合物 |
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CN201510351054.7A CN104926835B (zh) | 2015-06-24 | 2015-06-24 | 一种盐酸头孢替安化合物、其制备方法及其药物组合物 |
Publications (2)
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CN104926835A CN104926835A (zh) | 2015-09-23 |
CN104926835B true CN104926835B (zh) | 2017-10-03 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109134506A (zh) * | 2017-07-19 | 2019-01-04 | 宁应 | 一种一水盐酸头孢替安化合物及其药物组合物 |
CN109160924A (zh) * | 2017-07-26 | 2019-01-08 | 海南美大制药有限公司 | 一种二水盐酸头孢替安化合物及其药物组合物制剂 |
CN107519172A (zh) * | 2017-09-11 | 2017-12-29 | 浙江永宁药业股份有限公司 | 一种头孢替安盐酸盐有机碱组合物及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS603314B2 (ja) * | 1976-08-31 | 1985-01-26 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
CN101096373A (zh) * | 2006-06-28 | 2008-01-02 | 哈药集团制药总厂 | 头孢替安二水二盐酸盐的制备方法 |
CN101544662B (zh) * | 2009-05-12 | 2011-03-30 | 海南数尔药物研究有限公司 | 盐酸头孢替安化合物及其制成的药物组合物 |
CN104337768B (zh) * | 2014-08-29 | 2016-08-24 | 四川制药制剂有限公司 | 注射用盐酸头孢替安的制备方法 |
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- 2015-06-24 CN CN201510351054.7A patent/CN104926835B/zh active Active
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CB03 | Change of inventor or designer information |
Inventor after: Liu Xinquan Inventor after: Zhu Zhengchuan Inventor after: Zhu Quanming Inventor after: Zheng Susu Inventor before: Liu Xinquan Inventor before: Feng Chunxiang Inventor before: Zhu Quanming Inventor before: Zheng Susu |
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TR01 | Transfer of patent right |
Effective date of registration: 20190603 Address after: 276017 Luoqi Road, Luozhuang District, Linyi City, Shandong Province Co-patentee after: Shandong Luoxin Pharmaceutical Group Hengxin Pharmacy Co., Ltd. Patentee after: Shandong Luo Xin Pharmaceutical Group Plc Co-patentee after: Shandong Yu Xin pharmaceutcal corporation, Ltd Address before: 276017 Luoqi Road, Luozhuang District, Linyi City, Shandong Province Patentee before: Shandong Luo Xin Pharmaceutical Group Plc |
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