CN104922266A - Antibacterial fluid for treating onychomycosis and tinea of feet and hands, and preparation method thereof - Google Patents

Antibacterial fluid for treating onychomycosis and tinea of feet and hands, and preparation method thereof Download PDF

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Publication number
CN104922266A
CN104922266A CN201510209539.2A CN201510209539A CN104922266A CN 104922266 A CN104922266 A CN 104922266A CN 201510209539 A CN201510209539 A CN 201510209539A CN 104922266 A CN104922266 A CN 104922266A
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parts
fructus
tinea
chinese medicine
vinegar
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杨卫国
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Abstract

The invention discloses antibacterial fluid for treating onychomycosis and tinea of feet and hands, and a preparation method thereof. A traditional Chinese medicine composition of the antibacterial fluid comprises the following components in parts by weight: 5-25 parts of clove, 5-20 parts of capsicum annuum, 10-45 parts of cortex pseudolaricis, 5-30 parts of lightyellow sophora root, 10-30 parts of selinum japenious seed, 5-20 parts of belvedere fruit and 10-30 parts of vinegar or acetic acid. The preparation method comprises the following steps: extracting main effective components of the traditional Chinese medicine composition by using a new modern preparation technology for medication, adding some auxiliary materials, and then preparing traditional Chinese medicine liquid. The antibacterial fluid has the effects of killing the pests, dispelling the wind, arresting the itching, clearing the heat, drying the dampness, promoting the diuresis and removing the dampness. Symptoms such as foot erosion, blistering, itching, thickening, hardening, desquamation and cracking of foot cuticle, and graying and thickening of fingernails caused by the onychomycosis and the tinea of the feet and the hands are treated.

Description

One treats tinea unguium and tinea manus and pedis antimicrobial fluid and preparation method
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of tinea unguium, tinea manus and pedis, particularly one treats tinea unguium, tinea manus and pedis antimicrobial fluid and preparation method, belongs to technical field of Chinese medicines.
Background technology
In recent years, along with the change of people life style and mode of operation, tinea unguium, tinea manus and pedis become the disease of a kind of high incidence that annoying people, bring endless pain constricted to daily life.The disease of western medical treatment tinea unguium, tinea manus and pedis is the etiological treatment for pathogenic bacterium, doctor trained in Western medicine technology is in the treatment of tinea unguium, tinea manus and pedis disease in recent years, repeatedly use broad ectrum antibiotic in a large number, toxic and side effects is large, DeGrain, easy recurrence, and cause obvious lesions of liver and kidney, cause dysbacteriosis in patient body, immunity degradation simultaneously, the pathogen that script is not cured the disease, fungus, microorganism amount reproduction, become the root of bringing out new infection or increasing the weight of original infection.In sum, treatment tinea unguium, tinea manus and pedis are lasting processes, require patient's long-term prescription, and Western medicine untoward reaction is serious, and curative effect is unstable, and costly, the reason such as to cure the symptoms, not the disease makes it be restricted when in use.As: " Tropical China medical science " S1 phase in 2002 the 2 parts of ketoconazole liniments treatment routine observation of curative effect of tinea unguium 30 (author: yellow Zhou Zhu, Xing Yun), main Western medicine is exactly ketoconazole, and curative effect is general, large to the health toxic and side effects of patient, easily recurs.And for example " Skin bacterial flora combined acetic acid liquid treatment tinea cruris and tinea manus and pedis efficacy analysis " (author: Liu enters fragrant Li great Ning INTERNET), primarily of Flos Lonicerae, Radix Gentianae, Herba Taraxaci, Fructus Cnidii, Rhizoma Smilacis Glabrae, 3% ~ 5% acetate solution composition.Treatment tinea unguium, tinea manus and pedis curative effect still can.
Be used for the treatment of the Chinese medicine Western medicine aspect of tinea unguium, tinea manus and pedis at present, there is the deficiency of three aspects: one, effect is obvious not, two, take effect slower, three, can not for pathogenesis, treating both the principal and secondary aspects of a disease.Due to above-mentioned former, make a lot of patient can not get effective Drug therapy for a long time, occur that medication is just better, just outbreak need not wait delay difficult good situation repeatedly.
For the problems referred to above, the invention provides a kind of Chinese medicine composition for the treatment of tinea unguium, tinea manus and pedis, prescription is particular about " YIN and YANG balancing " " globality " " dialectical nature ", from at all, treating both the principal and secondary aspects of a disease, and solve the most medicine DeGrain of Chinese medicine, take effect slower problem, effective instant effect, determined curative effect.We are for the tinea corporis tinea cruris caused because of fungal infection simultaneously, shoe-sock sterilizing, and remove abnormal flavour, effect is equally strange good.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of tinea unguium, tinea manus and pedis, the shortcoming and defect of above-mentioned existing technology can be overcome, also there is direct use, Be very effective, low price simultaneously, the feature that cure rate is high.
Still demand is there is in current people for the Chinese medicine composition for the treatment of tinea unguium, tinea manus and pedis has better curative effect.Up to the present, not yet find the data destroying novelty of the present invention, present inventor, by clinical practice, have collected a large amount of clinical observation material, achieves the Chinese medicine composition for the treatment of tinea unguium, tinea manus and pedis has better curative effect, thus completes the present invention.
Technical solution of the present invention:
Treat an antimicrobial fluid for tinea unguium and tinea manus and pedis, adopt vinegar or vinegar essence, Flos Caryophylli, Fructus Zanthoxyli to be main, Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Cortex Pseudolaricis are that accessory drugs formulated forms;
Raw material composition with parts by weight is, Flos Caryophylli 5-25 part, Fructus Zanthoxyli 5-20 part, Cortex Pseudolaricis 10-45 part, Radix Sophorae Flavescentis 5-30 part, Fructus Cnidii 10-30 part, Fructus Kochiae 5-20 part, vinegar or acetic acid 10-30 part.
This preparation method is:
(1), by vinegar or vinegar essence, Flos Caryophylli, Fructus Zanthoxyli carry out lixiviate, soak 7-50 days by proportioning mixing, then extract solution for later use;
(2), by Cortex Pseudolaricis 10-45 part, Radix Sophorae Flavescentis 5-30 part, Fructus Cnidii 10-30 part, Fructus Kochiae 5-20 part is cleaned respectively, is dried, then is ground into lamellar or powdery, mixes by proportioning;
(3), by the Cortex Pseudolaricis by proportioning mixing, Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae adds water by 1: 3-5, inserts high temperature steaming 3-4 hour, temperature 100-130 DEG C in reactor;
(4), by the solution after high temperature steaming carry out sucking filtration, get filtrate and cool stand-by;
(5), again the medicinal liquid after lixiviate is mixed by proportioning with the medicinal liquid of sucking filtration, i.e. obtained product.
Preferred feedstock composition with parts by weight is, Flos Caryophylli 15 parts, Fructus Zanthoxyli 12 parts, Cortex Pseudolaricis 28 parts, Radix Sophorae Flavescentis 18 parts, Fructus Cnidii 20 parts, the Fructus Kochiae 12 parts, vinegar or acetic acid 20 parts.
Treat a Chinese medicine composition for tinea unguium and tinea manus and pedis, it is characterized in that each ingredients weight parts of described Chinese medicine composition is as follows: Flos Caryophylli 5-25 part, Fructus Zanthoxyli 5-20 part, Cortex Pseudolaricis 10-45 part, Radix Sophorae Flavescentis 5-30 part, Fructus Cnidii 10-30 part, Fructus Kochiae 5-20 part, vinegar or acetic acid 10-30 part.
The each ingredients weight parts of preferred described Chinese medicine composition is as follows: Flos Caryophylli 15 parts, Fructus Zanthoxyli 12 parts, Cortex Pseudolaricis 28 parts, Radix Sophorae Flavescentis 18 parts, Fructus Cnidii 20 parts, the Fructus Kochiae 12 parts, vinegar or acetic acid 20 parts.
The dosage form of described Chinese medicine composition is liquid.
The described a kind of application of Chinese medicine composition in treatment tinea unguium and tinea manus and pedis medicine for the treatment of tinea unguium and tinea manus and pedis.
A kind ofly comprise the treatment tinea unguium of described Chinese medicine composition and the medicine of tinea manus and pedis.
Pharmaceutical formulation of the present invention is through clinical practice for many years, in conjunction with Basic Theories of Chinese Medicine and modern scientific research method, investigates further and develops, meticulously screen raw material of Chinese medicine:
Flos Caryophylli: pungent, warm, enters stomach, spleen, kidney channel.Warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI, controls tinea disease.
Fructus Zanthoxyli: pungent, numb, warm, returns spleen, stomach, kidney channel.Warming middle-JIAO to relieve pain, killing parasites for relieving itching.
Cortex Pseudolaricis: pungent, warm, poisonous, returns lung, spleen channel.Killing parasites for relieving itching, controls scabies pruritus.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature, GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, parasite killing, diuresis.
Fructus Cnidii: acrid in the mouth, hardship, warm in nature.Return kidney channel.Dampness is dispeled the wind, killing parasites for relieving itching, warming the kidney to invigorate YANG.
The Fructus Kochiae: acrid in the mouth, hardship, cold in nature.Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.
Vinegar or acetic acid: fungus is afraid of acid, and vinegar can suppress even to kill fungus.Effective ingredient inside Chinese herbal medicine can leach by acetic acid, can moisten foster skin.
The traditional Chinese medical science is thought, the many poison damp and hot by diseases caused by exogenous pathogenic factor of the tinea manuum, pent up skin, or contact with each other, and malicious evil infection forms.The formation of tinea pedis is many because taste two are through damp invasion of lower energizer, or occupies wetland for a long time, works in hands, and water slurry floods, and infects caused by noxious dampness.Sick damp and hot dryness-transformation blood trouble of a specified duration then failure of skin and muscle to be nourished, causes pachylosis, season cracking, does not prolongedly heal.
Tinea unguium is many because of outer dye worm heresy, and invasion and attack onyx, pawl is become homeless and supported and cause.Or with the passing of time the malicious heresy of tinea manus and pedis spreads to deck, accumulates, do not allow pawl with hyperamization in noxious dampness, also can cause primary disease.
Therefore, this Chinese medicine formula selects Flos Caryophylli, Fructus Zanthoxyli, Cortex Pseudolaricis, Radix Sophorae Flavescentis, Fructus Cnidii, Fructus Kochiae parasite killing dispelling wind for relieving itching, effect of heat clearing and damp drying, diuresis dampness removing.Vinegar is substrate, and priming is deep, and it is acid, from lignify, controls wind disease, plays dispelling wind for relieving itching, moistens the effect of foster skin.All medicines share, and play skin moistening softening the hard mass altogether, the merit of killing parasites for relieving itching.
The present invention has parasite killing dispelling wind for relieving itching, effect of heat clearing and damp drying, diuresis dampness removing.Cure mainly the diseases such as skin pruritus caused by tinea unguium, tinea manus and pedis, foot bifurcation is rotten to the corn, fingernail is greyish white.
Described treatment tinea unguium, the Chinese medicine composition preparation technology of tinea manus and pedis are when meeting " technical requirement of new Chinese medicine Study on Preparation ", the effective constituent that mainly contains using Modern preparations new technique to extract Chinese medicine composition is used as medicine, add some accessory substances (adjuvant), as water etc., then make the Chinese medicinal liquor etc. for soaking brothers affected part, spray disinfection.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but scope of the present invention is not limited to following embodiment.
Embodiment 1
The present invention is described further by clinical observation and enforcement case
Clinical observation on the therapeutic effect data
1, clinical physical data: the actual efficacy being checking medicine of the present invention, apply medicine of the present invention and coordinates clinical treatment tinea manus and pedis (pathomycete because of tinea unguium, tinea manus and pedis is the same, can cure tinea manus and pedis, also can cure tinea unguium.So, here just to treat the clinical case of tinea manus and pedis), accept patient 120 example altogether for medical treatment, age distribution is as follows: less than 30 years old 16 example, 30-35 years old 25 example, 35-45 years old 38 example, more than 45 years old 41 example; The oldest 70 years old, minimum 24 years old of age; Unmarried 30 examples, married 90 examples.
2, diagnosis index
(1) clinical symptoms: foot bifurcation is rotten to the corn, goes out blister, pruritus.Sole cuticle thickening is hardening, desquamation, cracking etc.
(2) the direct microscopy of scurf fungus is positive.
3, Therapeutic Method:
Raw material composition with parts by weight is, Flos Caryophylli 5-25 gram, Fructus Zanthoxyli 5-20 gram, Cortex Pseudolaricis 10-45 gram, Radix Sophorae Flavescentis 5-30 gram, Fructus Cnidii 10-30 gram, Fructus Kochiae 5-20 gram, vinegar or acetic acid 10-30 gram.
Preferred: Flos Caryophylli 15 grams, Fructus Zanthoxyli 12 grams, Cortex Pseudolaricis 28 grams, Radix Sophorae Flavescentis 18 grams, Fructus Cnidii 20 grams, the Fructus Kochiae 12 grams, vinegar or acetic acid 20 grams.
Be prepared into antimicrobial fluid as follows:
(1), by vinegar or vinegar essence, Flos Caryophylli, Fructus Zanthoxyli carry out lixiviate, soak 7-50 days by proportioning mixing, then extract solution for later use;
(2), by Cortex Pseudolaricis 10-45 part, Radix Sophorae Flavescentis 5-30 part, Fructus Cnidii 10-30 part, Fructus Kochiae 5-20 part is cleaned respectively, is dried, then is ground into lamellar or powdery, mixes by proportioning;
(3), by the Cortex Pseudolaricis by proportioning mixing, Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae adds water by 1: 3-5, inserts high temperature steaming 3-4 hour, temperature 100-130 DEG C in reactor;
(4), by the solution after high temperature steaming carry out sucking filtration, get filtrate and cool stand-by;
(5), again the medicinal liquid after lixiviate is mixed by proportioning with the medicinal liquid of sucking filtration, i.e. obtained this patent product.Bottling, packaging.
Obtained antimicrobial fluid poured into inside special plastic bag, a foot soaks a sack, soak time about ten minutes.20 days courses for the treatment of, 1-2 courses for the treatment of reach rehabilitation substantially, consolidate and can reach curative effect 1-2 courses for the treatment of.
4, efficacy evaluation result
Recovery from illness: clinical symptom disappearance, the direct microscopy of scurf fungus is negative.
Effective: clinical symptom disappearance or obviously alleviate.
Take a turn for the better: subjective symptoms disappears or significantly alleviates, without blister, foot bifurcation without erosion, not pruritus.
5, therapeutic outcome.
By the conventional therapy of 1-3 courses for the treatment of, clinical symptoms can be changed rapidly; Cure 67 examples; Effective: 36 examples; Take a turn for the better: 11 examples; Invalid 6 examples; Total effective rate 95%.
Embodiment 2: Flos Caryophylli 5 grams, Fructus Zanthoxyli 5 grams, Cortex Pseudolaricis 45 grams, Radix Sophorae Flavescentis 15 grams, Fructus Cnidii 10 grams, the Fructus Kochiae 10 grams, vinegar or acetic acid 10 grams.
Embodiment 3: Flos Caryophylli 5 grams, Fructus Zanthoxyli 20 grams, Cortex Pseudolaricis 10 grams, Radix Sophorae Flavescentis 30 grams, Fructus Cnidii 10 grams, the Fructus Kochiae 5 grams, vinegar or acetic acid 20 grams.
Embodiment 4: Flos Caryophylli 10 grams, Fructus Zanthoxyli 10 grams, Cortex Pseudolaricis 15 grams, Radix Sophorae Flavescentis 5 grams, Fructus Cnidii 30 grams, the Fructus Kochiae 10 grams, vinegar or acetic acid 20 grams.
Embodiment 5: Flos Caryophylli 25 grams, Fructus Zanthoxyli 5 grams, Cortex Pseudolaricis 20 grams, Radix Sophorae Flavescentis 10 grams, Fructus Cnidii 15 grams, the Fructus Kochiae 10 grams, vinegar or acetic acid 15 grams.
Embodiment 6: Flos Caryophylli 10 grams, Fructus Zanthoxyli 10 grams, Cortex Pseudolaricis 15 grams, Radix Sophorae Flavescentis 20 grams, Fructus Cnidii 10 grams, the Fructus Kochiae 20 grams, vinegar or acetic acid 15 grams.
Embodiment 7: Flos Caryophylli 15 grams, Fructus Zanthoxyli 5 grams, Cortex Pseudolaricis 10 grams, Radix Sophorae Flavescentis 15 grams, Fructus Cnidii 10 grams, the Fructus Kochiae 15 grams, vinegar or acetic acid 30 grams.
The foregoing is only preferred embodiment of the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., be all included in protection scope of the present invention.

Claims (8)

1. treat an antimicrobial fluid for tinea unguium and tinea manus and pedis, it is characterized in that adopting vinegar or vinegar essence, Flos Caryophylli, Fructus Zanthoxyli to be main, Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Cortex Pseudolaricis are that accessory drugs formulated forms;
Raw material composition with parts by weight is, Flos Caryophylli 5-25 part, Fructus Zanthoxyli 5-20 part, Cortex Pseudolaricis 10-45 part, Radix Sophorae Flavescentis 5-30 part, Fructus Cnidii 10-30 part, Fructus Kochiae 5-20 part, vinegar or acetic acid 10-30 part.
2. the preparation method of a kind of antimicrobial fluid according to claim 1, is characterized in that this preparation method is:
(1), by vinegar or vinegar essence, Flos Caryophylli, Fructus Zanthoxyli carry out lixiviate, soak 7-50 days by proportioning mixing, then extract solution for later use;
(2), by Cortex Pseudolaricis 10-45 part, Radix Sophorae Flavescentis 5-30 part, Fructus Cnidii 10-30 part, Fructus Kochiae 5-20 part is cleaned respectively, is dried, then is ground into lamellar or powdery, mixes by proportioning;
(3), by the Cortex Pseudolaricis by proportioning mixing, Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae adds water by 1: 3-5, inserts high temperature steaming 3-4 hour, temperature 100-130 DEG C in reactor;
(4), by the solution after high temperature steaming carry out sucking filtration, get filtrate and cool stand-by;
(5), again the medicinal liquid after lixiviate is mixed by proportioning with the medicinal liquid of sucking filtration, i.e. obtained product.
3. a kind of antimicrobial fluid according to claim 1 and 2, is characterized in that, raw material composition with parts by weight is, Flos Caryophylli 15 parts, Fructus Zanthoxyli 12 parts, Cortex Pseudolaricis 28 parts, Radix Sophorae Flavescentis 18 parts, Fructus Cnidii 20 parts, the Fructus Kochiae 12 parts, vinegar or acetic acid 20 parts.
4. treat a Chinese medicine composition for tinea unguium and tinea manus and pedis, it is characterized in that each ingredients weight parts of described Chinese medicine composition is as follows: Flos Caryophylli 5-25 part, Fructus Zanthoxyli 5-20 part, Cortex Pseudolaricis 10-45 part, Radix Sophorae Flavescentis 5-30 part, Fructus Cnidii 10-30 part, Fructus Kochiae 5-20 part, vinegar or acetic acid 10-30 part.
5. a kind of Chinese medicine composition for the treatment of tinea unguium and tinea manus and pedis according to claim 4, is characterized in that each ingredients weight parts of described Chinese medicine composition is as follows: Flos Caryophylli 15 parts, Fructus Zanthoxyli 12 parts, Cortex Pseudolaricis 28 parts, Radix Sophorae Flavescentis 18 parts, Fructus Cnidii 20 parts, the Fructus Kochiae 12 parts, vinegar or acetic acid 20 parts.
6. a kind of Chinese medicine composition for the treatment of tinea unguium and tinea manus and pedis according to claim 4 or 5, is characterized in that, the dosage form of described Chinese medicine composition is liquid.
7. a kind of application of Chinese medicine composition in treatment tinea unguium and tinea manus and pedis medicine for the treatment of tinea unguium and tinea manus and pedis according to claim 4 or 5.
8. one kind comprises the treatment tinea unguium of the Chinese medicine composition described in claim 4 or 5 and the medicine of tinea manus and pedis.
CN201510209539.2A 2015-04-29 2015-04-29 Antibacterial fluid for treating onychomycosis and tinea of feet and hands, and preparation method thereof Pending CN104922266A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840481A (en) * 2020-08-06 2020-10-30 湖南巨禧医药科技有限公司 Medicament for quickly removing onychomycosis and preparation method thereof

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