CN111840481A

CN111840481A - Medicament for quickly removing onychomycosis and preparation method thereof

Info

Publication number: CN111840481A
Application number: CN202010781272.5A
Authority: CN
Inventors: 谭喜
Original assignee: Hunan Juxi Pharmaceutical Technology Co ltd
Current assignee: Hunan Juxi Pharmaceutical Technology Co ltd
Priority date: 2020-08-06
Filing date: 2020-08-06
Publication date: 2020-10-30

Abstract

The invention discloses a medicament for quickly removing onychomycosis and a preparation method thereof, wherein the medicament comprises the following components: 7-23 parts of clove, 7-18 parts of pericarpium zanthoxyli, 12-40 parts of pseudolarix, 8-25 parts of radix sophorae flavescentis, 12-25 parts of fructus cnidii, 8-15 parts of fructus kochiae, 6-15 parts of salvia miltiorrhiza, 6-20 parts of radix stemonae, 4-10 parts of salicylic acid, 5-12 parts of borneol, 10-20 parts of water-soluble polyethylene glycol succinimide succinate and 2-4 parts of trilysine acetate. Compared with the prior art, the invention has excellent treatment effect.

Description

Medicament for quickly removing onychomycosis and preparation method thereof

Technical Field

The invention relates to a medicament for removing onychomycosis, in particular to a medicament for quickly removing onychomycosis and a preparation method thereof.

Background

Onychomycosis is a disease caused by dermatophyte invading the nail plate, and is a mycosis occurring on the nail and under the nail. It is a dermatosis that causes structural change, color change and mutual infection of nail of finger (toe), the main manifestation of onychomycosis is: the nail is deformed, thickened, easy to fall off and separated. Paronychia (paronychia) is an inflammatory reaction involving the periungual skin folds, manifested by acute or chronic purulent, tender and painful periungual tissue swelling, caused by abscess of the nail folds; when the infection becomes chronic, the methyl base presents with a transverse crest and with recurrence a new crest; finger involvement is more common than toes, the main susceptibility factor is separation of nail epithelium and nail plate due to injury, pyococcus or yeast can secondarily invade moist nail groove and nail fold, and the common pathogenic bacteria are staphylococcus aureus, streptococcus pyogenes, pseudomonas, proteus or anaerobe; the most common pathogenic yeast is Candida albicans. In view of the need for improvement of the treatment effect of the existing medicament on onychomycosis, the inventors of the present application, through intensive research, obtain a medicament for rapidly removing onychomycosis and a preparation method thereof.

Disclosure of Invention

The invention aims to provide a medicament for quickly removing onychomycosis and a preparation method thereof, and the medicament has the advantage of good treatment effect.

The technical purpose of the invention is realized by the following technical scheme:

a medicament for rapidly removing onychomycosis comprises the following components: 7-23 parts of clove, 7-18 parts of pericarpium zanthoxyli, 12-40 parts of pseudolarix, 8-25 parts of radix sophorae flavescentis, 12-25 parts of fructus cnidii, 8-15 parts of fructus kochiae, 6-15 parts of salvia miltiorrhiza, 6-20 parts of radix stemonae, 4-10 parts of salicylic acid, 5-12 parts of borneol, 10-20 parts of water-soluble polyethylene glycol succinimide succinate and 2-4 parts of trilysine acetate.

The further improvement comprises the following components: 7 parts of clove, 7 parts of pericarpium zanthoxyli, 12 parts of pseudolarix, 8 parts of radix sophorae flavescentis, 12 parts of fructus cnidii, 8 parts of fructus kochiae, 6 parts of salvia miltiorrhiza, 6 parts of radix stemonae, 4 parts of salicylic acid, 5 parts of borneol, 10 parts of water-soluble polyethylene glycol succinimide succinate and 2 parts of trilysine acetate.

The further improvement comprises the following components: 23 parts of clove, 18 parts of pericarpium zanthoxyli, 40 parts of pseudolarix, 25 parts of radix sophorae flavescentis, 25 parts of fructus cnidii, 15 parts of fructus kochiae, 15 parts of salvia miltiorrhiza, 20 parts of radix stemonae, 10 parts of salicylic acid, 12 parts of borneol, 20 parts of water-soluble polyethylene glycol succinimide succinate and 4 parts of trilysine acetate.

The further improvement comprises the following components: 15 parts of clove, 12 parts of pericarpium zanthoxyli, 26 parts of pseudolarix, 16 parts of radix sophorae flavescentis, 18 parts of fructus cnidii, 11 parts of fructus kochiae, 10 parts of salvia miltiorrhiza, 13 parts of radix stemonae, 12 parts of salicylic acid, 8 parts of borneol, 15 parts of water-soluble polyethylene glycol succinimide succinate and 3 parts of trilysine acetate.

A preparation method of a medicament for quickly removing onychomycosis comprises the following steps:

the method comprises the following steps: soaking 4-10 parts of salicylic acid, 7-23 parts of clove and 7-18 parts of pericarpium zanthoxyli for 30-40 days, and taking a leaching solution for later use;

step two: respectively crushing 12-40 parts of cortex pseudolaricis, 8-25 parts of radix sophorae flavescentis, 12-25 parts of fructus cnidii, 8-15 parts of fructus kochiae, 6-15 parts of salvia miltiorrhiza and 6-20 parts of radix stemonae into powder, and then mixing to obtain a mixture;

step three: adding 3-5 times of water by weight into the mixture, and cooking for 3-5 hours at the temperature of 100-130 ℃;

step four: carrying out suction filtration on a product obtained after cooking, and cooling to obtain a filtrate;

step five: mixing the leachate and the filtrate, and adding 5-12 parts of borneol, 10-20 parts of water-soluble polyethylene glycol succinimide succinate and 2-4 parts of trilysine acetate to obtain the product.

The crushing process in the second step is carried out by adopting a crushing device, the crushing device comprises a crushing cavity, a first driving device and a second driving device, the crushing cavity comprises a shell, a cutter and a plurality of separators, the cutter comprises a driver and a plurality of cutter heads, the driver is arranged in the shell, the cutter heads are connected with the driver and radially distributed by taking the driver as the center, the first driving device is connected with the driver, the separators are arranged in the shell and radially distributed by taking the driver as the center to divide the interior of the shell into a plurality of independent cavities, the separators are provided with a first side surface and a second side surface which are respectively positioned in two adjacent cavities, the second side surface is provided with a butt strap, and the side edges of the butt strap are rotationally connected to the second side surface, the first side surface penetrates through the isolating piece and is provided with a plurality of sieve pores, when the lapping plate covers on the isolating piece, the lapping plate covers the sieve pores, in the isolating pieces, the direction of the first side surface pointing to the second side surface is arranged on the lapping plate, the pore diameters of the sieve pores are gradually reduced, the cavity is provided with an opening and closing door, each of the cutter heads extends into one of the cavity, and the second driving device is used for driving the crushing cavity to rotate.

In a further improvement, the first driving device is a first motor, the second driving device comprises a second motor and a friction wheel, the second motor is connected with the friction wheel and used for driving the friction wheel to rotate, a friction ring is arranged on the edge of the crushing cavity, and the friction wheel is in contact with the friction ring; a groove is formed in one side, far away from the first side face, of the butt strap, an attraction block is arranged in the groove and made of a magnet, and the isolating piece is made of a magnetic material.

The improved door comprises a door body and an extending edge surrounding the door body, wherein the extending edge is made of magnets, the peripheral wall of the crushing cavity is made of magnetic materials, a plurality of sockets which are in one-to-one correspondence with the cavity are formed in the peripheral wall of the crushing cavity, one socket in the sockets is inserted into the door body, and the extending edge is adsorbed on the edge of the socket.

In a further improvement, the soaking process in the first step is carried out by adopting a soaking device, the soaking device comprises a barrel body, a magnet, an electromagnet and an elastic supporting seat, the barrel body is arranged on the elastic supporting seat, the electromagnet is arranged below the barrel body, and the magnet corresponding to the electromagnet is arranged at the bottom of the barrel body.

In a further improvement, the elastic support seat comprises a bearing frame, a base and a plurality of springs, the springs are arranged between the bearing frame and the base, the electromagnet is arranged on the base, the bearing frame is positioned above the base, and the barrel body is arranged on the bearing frame.

Compared with the prior art, the invention provides a medicament for quickly removing onychomycosis, which extracts effective components from various medicinal materials, has excellent bactericidal effect, simultaneously selects the medicinal materials with lower cost and lower production cost, and the composition of the water-soluble polyethylene glycol succinimide succinate and the trilysine acetate contained in the medicament can prolong the detention time of the medicament at the focus, adjust the release rate of the medicament and improve the rheological property of the medicament, thereby enhancing the anti-inflammatory effect of the medicament while reducing the dosage of the medicament;

the invention also provides a preparation method of the medicament for quickly removing onychomycosis, which comprises the steps of firstly, leaching and extracting effective components in clove and pericarpium zanthoxyli by using salicylic acid, simultaneously, grinding 8-25 parts of cortex pseudolaricis, 8-25 parts of radix sophorae flavescentis, fructus cnidii, fructus kochiae, radix salviae miltiorrhizae and radix stemonae into powder and mixing, mixing the products obtained in the two steps, adding water, cooking to extract the effective components in medicinal materials, and then adding borneol, water-soluble polyethylene glycol succinimide succinate and trilysine acetate to obtain a product; the crushing device used in the preparation process can realize good crushing effect to ensure that the crushed particles are uniform, particularly, in the working process, the first driving device drives a plurality of cutter heads to rotate by utilizing the transmission action of a driver, a plurality of cavities are separated by a plurality of separating parts in the crushing cavity, sieve holes are arranged on the separating parts, the sieve holes on the separating parts are different in size and gradually reduced, meanwhile, the separating parts are also provided with an access board, under the structural arrangement, the medicinal material is firstly put into one cavity adjacent to the separating part with the largest sieve hole to seal the cavity, the second driving device drives the crushing cavity to rotate, the medicinal material is firstly crushed in the cavity, when the passing condition of the sieve holes of the separating part adjacent to the medicinal material is met, the medicinal material enters the other cavity to be continuously crushed, and the access board is used for controlling the direction of the medicinal material passing through the sieve holes, in the process, the medicinal materials are crushed into a certain particle size, enter another cavity, are cut again and then enter the next cavity, thereby realizing graded crushing, further realizing good crushing effect, leading the granularity of the medicinal materials to be more uniform, in the cooking process, the effective components in the medicinal materials can be more effectively extracted because it is difficult to precisely control the cooking time when the particle size is not uniform, because the granularity can not be controlled definitely, the effective cost in the medicinal materials can not be known when the medicinal materials are extracted thoroughly, so that the standardized production is difficult, and the granularity can be uniform and controllable by adopting the crushing device of the invention, the granularity of the finally obtained crushed medicinal material is relatively determined, so that the time for soaking and cooking is relatively easy to determine, and the effective components in the medicinal material are relatively thoroughly extracted;

further, the soaker is still used at the in-process of preparation, and the soaker includes staving, magnet, electro-magnet and elastic support seat, and elastic support seat realizes the elastic support to the staving, and at the in-process of soaking, the electro-magnet intermittent type nature circular telegram forms the intermittent type nature attraction to the magnet, and the effect performance is for the staving produces the vibration for original emergence in the staving rocks, makes effective cost in the medicinal material can add and dissolve, thereby effectively promotes production efficiency.

Drawings

FIG. 1 is a process flow chart of the preparation method of the medicament for quickly removing onychomycosis.

Fig. 2 is a schematic view of a crushing device used in the preparation method of the medicament for quickly removing the onychomycosis according to the present invention.

Fig. 3 is a second view of the crushing device used in the method for preparing the medicine for rapidly removing onychomycosis of the present invention.

Fig. 4 is a schematic view showing the internal structure of a crushing device used in the method for preparing a medicament for rapidly removing onychomycosis according to the present invention.

FIG. 5 is a schematic view of a first partition of a pulverizing apparatus used in a method of preparing a medicine for rapidly removing onychomycosis according to the present invention;

FIG. 6 is a schematic view of a second perspective of a first separator of a comminuting device used in a method of preparing a medicament for the rapid removal of onychomycosis according to the present invention

Fig. 7 is a structural schematic diagram of an opening and closing door of a crushing device used in the preparation method of the medicament for quickly removing the onychomycosis.

Fig. 8 is a schematic structural view of an infuser used in a method of preparing a medicament for rapidly removing onychomycosis according to the present invention.

Fig. 9 is a schematic view showing the internal structure of an infuser used in a method of preparing a medicament for rapidly removing onychomycosis according to the present invention.

Fig. 10 is a schematic structural view of the upper cover closure of a medicament bottle used in the preparation method of the medicament for quickly removing onychomycosis.

Fig. 11 is a schematic structural view of the opening of the upper cover of a medicine bottle used in the method for preparing the medicine for rapidly removing onychomycosis.

In the drawings

A crushing chamber 1; a friction ring 11; a first separator 12; a first strap 121; a first screen aperture 122; a first suction block 123; a second separator 13; a third separator 14; a fourth separator 15; a fifth separator 16; a sixth separator 17; a first cavity 21; a second lumen 22; a third cavity 23; a fourth cavity 24; a fifth cavity 25; a sixth cavity 26; a housing 31; a cutter head 32; an actuator 33; opening and closing the door 4; a door body 41; an extended edge 42; a first motor 51; a second motor 52; the friction wheel 53; a barrel body 61; an electromagnet 62; a carrier frame 63; a base 64; a spring 65; a bottle body 71; an air bag 72; an air jet-721; a shower head 73; a nozzle 74; and a bottle cap 75.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.

The first embodiment is as follows:

Example two:

a medicament for rapidly removing onychomycosis comprises the following components: 7 parts of clove, 7 parts of pericarpium zanthoxyli, 12 parts of pseudolarix, 8 parts of radix sophorae flavescentis, 12 parts of fructus cnidii, 8 parts of fructus kochiae, 6 parts of salvia miltiorrhiza, 6 parts of radix stemonae, 4 parts of salicylic acid, 5 parts of borneol, 10 parts of water-soluble polyethylene glycol succinimide succinate and 2 parts of trilysine acetate.

Example three:

a medicament for rapidly removing onychomycosis comprises the following components: 23 parts of clove, 18 parts of pericarpium zanthoxyli, 40 parts of pseudolarix, 25 parts of radix sophorae flavescentis, 25 parts of fructus cnidii, 15 parts of fructus kochiae, 15 parts of salvia miltiorrhiza, 20 parts of radix stemonae, 10 parts of salicylic acid, 12 parts of borneol, 20 parts of water-soluble polyethylene glycol succinimide succinate and 4 parts of trilysine acetate.

Example four:

a medicament for rapidly removing onychomycosis comprises the following components: 15 parts of clove, 12 parts of pericarpium zanthoxyli, 26 parts of pseudolarix, 16 parts of radix sophorae flavescentis, 18 parts of fructus cnidii, 11 parts of fructus kochiae, 10 parts of salvia miltiorrhiza, 13 parts of radix stemonae, 12 parts of salicylic acid, 8 parts of borneol, 15 parts of water-soluble polyethylene glycol succinimide succinate and 3 parts of trilysine acetate.

In the above embodiments, the effective components are extracted from various medicinal materials, so that the sterilizing effect is excellent, meanwhile, the medicinal materials with lower cost are selected, the production cost is lower, the water-soluble polyethylene glycol succinimide succinate and trilysine acetate composition contained in the composition can prolong the retention time of the medicament at the focus, adjust the release rate of the medicament, and improve the rheological property of the medicament, thereby reducing the dosage of the medicament and enhancing the anti-inflammatory effect of the medicament.

Example five:

a method for preparing a medicament for rapidly removing onychomycosis, as shown in figure 1, comprises the following steps:

step one S1: soaking 4-10 parts of salicylic acid, 7-23 parts of clove and 7-18 parts of pericarpium zanthoxyli for 30-40 days, and taking a leaching solution for later use;

step two S2: respectively crushing 12-40 parts of cortex pseudolaricis, 8-25 parts of radix sophorae flavescentis, 12-25 parts of fructus cnidii, 8-15 parts of fructus kochiae, 6-15 parts of salvia miltiorrhiza and 6-20 parts of radix stemonae into powder, and then mixing to obtain a mixture;

step three S3: adding 3-5 times of water by weight into the mixture, and cooking for 3-5 hours at the temperature of 100-130 ℃;

step four S4: carrying out suction filtration on a product obtained after cooking, and cooling to obtain a filtrate;

step five S5: mixing the leachate and the filtrate, and adding 5-12 parts of borneol, 10-20 parts of water-soluble polyethylene glycol succinimide succinate and 2-4 parts of trilysine acetate to obtain the product.

Referring to fig. 2 to 6, the crushing process in the second step is performed by using a crushing device, the crushing device includes a crushing cavity 1, a first driving device and a second driving device, the crushing cavity 1 includes a housing 31, a cutter and a plurality of spacers, the cutter includes a driver 33 and a plurality of cutter heads 32, the driver 33 is disposed in the housing 31, the cutter heads 32 are connected to the driver 33 and radially distributed with the driver 33 as a center, the first driving device is connected to the driver 33, the spacers are disposed in the housing 31 and radially distributed with the driver 33 as a center, the housing 31 is internally divided into a plurality of independent cavities, the spacers have a first side surface and a second side surface respectively disposed in two adjacent cavities, and a butt strap is disposed on the second side surface, the side of strap along rotate connect in on the second side, by first side runs through the separator is equipped with a plurality of sieve meshes, works as the strap cover in when on the separator, the strap covers a plurality of sieve meshes, in a plurality of separators, along the direction of the directional second side of first side, locate on it the aperture of sieve mesh reduces gradually, be equipped with on the cavity and open and close door 4, each in a plurality of tool bits 32 the tool bit 32 stretches into one in the cavity, second drive arrangement is used for the drive smash 1 rotations in the chamber.

Firstly, extracting effective components in clove and pericarpium zanthoxyli by salicylic acid, grinding cortex pseudolaricis, 8-25 parts of radix sophorae flavescentis, fructus cnidii, fructus kochiae, radix salviae miltiorrhizae and radix stemonae into powder, mixing the two products, adding water, cooking to extract the effective components in the medicinal materials, and then adding borneol, water-soluble polyethylene glycol succinimide succinate and trilysine acetate to obtain a product; the crushing device used in the preparation process can realize good crushing effect and enable particles obtained by crushing to be uniform, specifically, in the working process, the first driving device drives the plurality of cutter heads 32 to rotate by utilizing the transmission action of the transmission device 33, a plurality of cavities are separated by a plurality of separating parts in the crushing cavity 1, the separating parts are provided with sieve holes, the sieve holes on the separating parts are different in size and gradually reduced, meanwhile, the separating parts are also provided with an access board, under the structural arrangement, the medicinal material is firstly put into one cavity adjacent to the separating part with the largest sieve hole to seal the cavity, the second driving device drives the crushing cavity 1 to rotate, the medicinal material is firstly crushed in the cavity, when the passing condition of the sieve holes of the separating part adjacent to the medicinal material is met, the medicinal material enters the other cavity to be continuously crushed, and the access board is used for controlling the direction of the medicinal material passing through the sieve holes, in the process, the medicinal materials are crushed into a certain particle size, enter another cavity, are cut again and then enter the next cavity, thereby realizing graded crushing, further realizing good crushing effect, leading the granularity of the medicinal materials to be more uniform, in the cooking process, the effective components in the medicinal materials can be more effectively extracted because it is difficult to precisely control the cooking time when the particle size is not uniform, because the granularity can not be controlled definitely, the effective cost in the medicinal materials can not be known when the medicinal materials are extracted thoroughly, so that the standardized production is difficult, and the granularity can be uniform and controllable by adopting the crushing device of the invention, the granularity of the finally obtained crushed medicinal materials is relatively determined, so that the time for soaking and cooking is relatively easy to determine, and the effective components in the medicinal materials are relatively thoroughly extracted.

Wherein, opening and close of access board realizes through its action of gravity, and when the access board was in the position that leans on relatively, because the action of gravity, it was in the open mode, and the medicinal material has the condition through the sieve mesh, and when the access board was in the position that leans on, it was in the closed condition, and the medicinal material does not possess the condition through the sieve mesh.

The driver 33 is mainly used for realizing power transmission from the first driving device to the plurality of cutter heads 32, so that the plurality of cutter heads 32 rotate synchronously, specifically, the driver 33 should include a housing 31 and a plurality of bevel gears arranged inside the housing 31, a transmission shaft of the first driving device corresponds to one bevel gear, the plurality of cutter heads 32 correspond to one bevel gear respectively, and power transmission is realized through cooperation of the bevel gears.

In the present embodiment, the separators are provided in a plate shape, the number of which is 6, and which are respectively named as a first separator 12, a second separator 13, a third separator 14, a fourth separator 15, a fifth separator 16, and a sixth separator 17, thereby dividing the pulverization chamber 1 into 6 chambers, which are respectively a first chamber 21, a second chamber 22, a third chamber 23, a fourth chamber 24, a fifth chamber 25, and a sixth chamber 26, the first chamber 21 is located between the sixth separator 17 and the first separator 12, the second chamber 22 is located between the first separator 12 and the second separator 13, the third chamber 23 is located between the second separator 13 and the third separator 14, the fourth chamber 24 is located between the third separator 14 and the fourth separator 15, the fifth chamber 25 is located between the fourth separator 15 and the fifth separator 16, the sixth chamber 26 is located between the fifth separator 16 and the sixth separator 17, wherein, the aperture of the sieve mesh on the first separator 12 on the second separator 13, the aperture of the sieve mesh on the second separator 13 on the third separator 14, the aperture of the sieve mesh on the third separator 14 on the fourth separator 15, the aperture of the sieve mesh on the aperture fifth separator 16 on the fourth separator 15, the aperture of the sieve mesh on the aperture sixth separator 17 of the sieve mesh on the fifth separator 16, first separator 12, the second separator 13, the third separator 14, the fourth separator 15, fifth separator 16 and sixth separator 17 correspond respectively and set up first access 121, the second access, the third access, the fourth access, fifth access and sixth access, correspond respectively simultaneously first sieve mesh 122, the second sieve mesh, the third sieve mesh, the fourth sieve mesh, fifth sieve mesh and sixth sieve mesh.

Specifically, as shown in fig. 4, under the action of the second driving device, as shown by the arrow, the crushing cavity 1 rotates counterclockwise, due to the action of each strap, the material can only pass through the first cavity 21, the second cavity 22, the third cavity 23, the fourth cavity 24, the fifth cavity 25 and the sixth cavity 26 in sequence, but cannot pass through the sixth cavity 26, the fifth cavity 25, the fourth cavity 24, the third cavity 23, the second cavity 22 and the first cavity 21 in sequence, under the principle, the medicinal material is firstly put into the first cavity 21, the medicinal material capable of passing through the first separating member 12 enters the second cavity 22, and cannot be retained in the first cavity 21 until the medicinal material can pass through the first separating member 12, and finally, if no other obstacles are set, the medicinal material can completely enter the sixth cavity 26, the crushing process is completed, and since the crushing process is performed in stages, the next cavity is entered after the processing reaches the standard in one cavity, so that the medicinal materials with different particle sizes are effectively prevented from being crushed simultaneously, and the uniformity of the particle size can be effectively ensured.

Specifically, the first driving device is set as a first motor 51, the second driving device comprises a second motor 52 and a friction wheel 53, the second motor 52 is connected with the friction wheel 53 and is used for driving the friction wheel 53 to rotate, a friction ring 11 is arranged on the edge of the crushing cavity 1, and the friction wheel 53 is in contact with the friction ring 11; a groove is formed in one side, far away from the first side face, of the butt strap, an attraction block is arranged in the groove and made of a magnet, and the isolating piece is made of a magnetic material.

Under the above structure, on one hand, the second motor 52 drives the friction wheel 53 to rotate, and the friction wheel 53 drives the friction ring 11 to rotate, so as to drive the crushing cavity 1 to rotate, thereby driving the crushing cavity 1; on the other hand, by providing the suction block, the control of the particle size of the medicinal material can be realized, when the suction block is installed in the groove of the access plate, the corresponding access plate is closed and cannot be opened, when the suction block is removed, the corresponding access plate is opened and can be opened, the first access plate 121, the second access plate, the third access plate, the fourth access plate, the fifth access plate and the sixth access plate respectively correspond to the first suction block 123, the second suction block, the third suction block, the fourth suction block, the fifth suction block and the sixth suction block, for example, when the first suction block 123, the second suction block, the third suction block, the fifth suction block and the sixth suction block are removed, and when the fourth suction block is installed, the fourth access plate cannot be opened, the medicinal material can only reach the fourth cavity 24 at most and cannot enter the fifth cavity 25 and the sixth cavity 26, thereby the crushing particle size of the medicinal material is limited in the fourth cavity 24, the control of the granularity is realized.

Specifically, referring to fig. 7, the opening and closing door 4 includes a door body 41 and an extending edge 42 surrounding the door body 41, the extending edge 42 is made of a magnet, a peripheral wall of the pulverization chamber 1 is made of a magnetic material, a plurality of sockets are arranged on the peripheral wall of the pulverization chamber 1 and correspond to the cavities one by one, one of the sockets is inserted into one of the door bodies 41, and the extending edge 42 is attached to an edge of the socket. Under the structure, the opening and closing door 4 is arranged on the socket in an adsorption mode, so that the opening and closing of each cavity are very convenient; the removal of the suction block can also take place via the socket.

Referring to fig. 8 and 9, the soaking process in the first step is performed by using a soaking device, the soaking device includes a barrel 61, a magnet, an electromagnet 62 and an elastic support seat, the barrel 61 is disposed on the elastic support seat, the electromagnet 62 is installed below the barrel 61, and the magnet corresponding to the electromagnet 62 is disposed at the bottom of the barrel 61. The infuser includes staving 61, magnet, electro-magnet 62 and elastic support seat, and elastic support seat realizes the elastic support to staving 61, and at the in-process of soaking, electro-magnet 62 intermittent type nature circular telegram forms the intermittent type nature attraction to the magnet, and the effect shows to staving 61 produces the vibration for original emergence in the staving 61 rocks, makes effective cost in the medicinal material can add and dissolve, thereby effectively promotes production efficiency.

The elastic support seat comprises a bearing frame 63, a base 64 and a plurality of springs 65, the springs 65 are arranged between the bearing frame 63 and the base 64, the electromagnet 62 is arranged on the base 64, the bearing frame 63 is positioned above the base 64, and the barrel body 61 is arranged on the bearing frame 63.

After the preparation is completed, the medicine is filled into the medicine bottle for the user to use, referring to fig. 10 and 11, the medicine bottle comprises a bottle body 71, an air bag 72, a spray head 73 and a bottle cap 75, the spray head 73 is mounted on the bottle body 71, a nozzle 74 is arranged on the spray head 73, the air bag 72 is arranged in a ring shape and surrounds the spray head 73, an air jet 721 is arranged on the air bag 72, the bottle cap 75 is covered on the spray head 73, and the lower edge of the bottle cap abuts against the air bag 72. Under the above structure, after spraying, the bottle cap 75 is covered on the nozzle 73, and the bottle cap 75 is pressed, under the pressure of the bottle cap 75, the air jet 721 arranged on the air bag 72 blows air to blow the spraying part, so that the spraying part is dried quickly, on one hand, the medicament is prevented from being easily erased under the humid condition, and on the other hand, the influence on the normal action of people for a long time is avoided; it should be noted that the vial shown in the drawings is merely schematic and that in a practical arrangement the volume of the bladder 72 may be correspondingly larger to generate sufficient wind to promote rapid drying of the medicament.

Further, the nozzle 74 is provided with a sponge block, when the nozzle 73 is pressed down, the medicament is firstly sprayed on the sponge block and then wiped by the sponge block, so that the advantage of the arrangement is that the medicament is scattered around in a direct spraying manner, a large amount of medicament is wasted, the manner of firstly spraying on the sponge block can avoid the situation, and the medicament on the sponge block can be accurately smeared at the administration position.

A large number of clinical tests prove that the total effective rate can reach 91.51%, and the following data further prove the curative effect of the medicament.

One, general data: the patients in the group are 137 patients with onychomycosis in outpatient clinic treatment, and the clinical observation is carried out on the patients aiming at the medicament. 106 cases of the treatment group and 31 cases of the control group.

II, diagnosis standard: the diagnosis is made by the eye sight and touch, and the condition of the eye sight and the self-statement of the patient.

Thirdly, treatment standard: the nail asymptomatic is used as a cure, the nail asymptomatic development is controlled, the replacement of new nails is used as an obvious effect, the improvement that the nails have no continuous disease and no expansion phenomenon is used, and the medicament has no change on the disease.

Fourth, clinical case report

It should be noted that, in the present document, the parts are weight parts of the medicinal materials, and the relational terms such as first and second, and the like are only used for distinguishing one entity or operation from another entity or operation, and do not necessarily require or imply any actual relation or order between the entities or operations. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or terminal that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or terminal. Without further limitation, an element defined by the phrases "comprising … …" or "comprising … …" does not exclude the presence of additional elements in a process, method, article, or terminal that comprises the element. Further, herein, "greater than," "less than," "more than," and the like are understood to exclude the present numbers; the terms "above", "below", "within" and the like are to be understood as including the number.

The foregoing description of the embodiments is provided to facilitate an understanding and use of the invention and it will be apparent to those skilled in the art that various modifications to the embodiments and the generic principles defined herein may be applied to other embodiments without the use of inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.

Claims

1. A medicament method for quickly removing onychomycosis is characterized by comprising the following components: 7-23 parts of clove, 7-18 parts of pericarpium zanthoxyli, 12-40 parts of pseudolarix, 8-25 parts of radix sophorae flavescentis, 12-25 parts of fructus cnidii, 8-15 parts of fructus kochiae, 6-15 parts of salvia miltiorrhiza, 6-20 parts of radix stemonae, 4-10 parts of salicylic acid, 5-12 parts of borneol, 10-20 parts of water-soluble polyethylene glycol succinimide succinate and 2-4 parts of trilysine acetate.

2. The agent for rapidly removing onychomycosis according to claim 1, comprising the following components: 7 parts of clove, 7 parts of pericarpium zanthoxyli, 12 parts of pseudolarix, 8 parts of radix sophorae flavescentis, 12 parts of fructus cnidii, 8 parts of fructus kochiae, 6 parts of salvia miltiorrhiza, 6 parts of radix stemonae, 4 parts of salicylic acid, 5 parts of borneol, 10 parts of water-soluble polyethylene glycol succinimide succinate and 2 parts of trilysine acetate.

3. The agent for rapidly removing onychomycosis according to claim 1, comprising the following components: 23 parts of clove, 18 parts of pericarpium zanthoxyli, 40 parts of pseudolarix, 25 parts of radix sophorae flavescentis, 25 parts of fructus cnidii, 15 parts of fructus kochiae, 15 parts of salvia miltiorrhiza, 20 parts of radix stemonae, 10 parts of salicylic acid, 12 parts of borneol, 20 parts of water-soluble polyethylene glycol succinimide succinate and 4 parts of trilysine acetate.

4. The medicament for quickly removing the onychomycosis according to claim 1, which comprises the following components: 15 parts of clove, 12 parts of pericarpium zanthoxyli, 26 parts of pseudolarix, 16 parts of radix sophorae flavescentis, 18 parts of fructus cnidii, 11 parts of fructus kochiae, 10 parts of salvia miltiorrhiza, 13 parts of radix stemonae, 12 parts of salicylic acid, 8 parts of borneol, 15 parts of water-soluble polyethylene glycol succinimide succinate and 3 parts of trilysine acetate.

5. A preparation method of a medicament for quickly removing onychomycosis is characterized by comprising the following steps:

6. The method according to claim 5, wherein the crushing process in the second step is performed by using a crushing device comprising a crushing chamber, a first driving device and a second driving device, the crushing chamber comprises a housing, a cutter and a plurality of spacers, the cutter comprises an actuator and a plurality of blades, the actuator is disposed in the housing, the blades are connected to the actuator and radially distributed around the actuator, the first driving device is connected to the actuator, the spacers are disposed in the housing and radially distributed around the actuator, the housing is divided into a plurality of independent cavities, the spacers have a first side and a second side respectively disposed in two adjacent cavities, the second side is provided with an access board, the side edges of the access board are rotationally connected to the second side, the first side penetrates through the partition part and is provided with a plurality of sieve holes, when the access board covers the partition part, the access board covers the sieve holes, the sieve holes are arranged on the partition part along the direction of the first side pointing to the second side, the aperture of the sieve holes is gradually reduced, the cavity is provided with an opening and closing door, each of the cutter heads extends into one of the cavity, and the second driving device is used for driving the crushing cavity to rotate.

7. The method for preparing a medicament for rapidly removing onychomycosis according to claim 6, wherein the first driving means is a first motor, the second driving means comprises a second motor and a friction wheel, the second motor is connected with the friction wheel for driving the friction wheel to rotate, a friction ring is arranged on the edge of the grinding cavity, and the friction wheel is in contact with the friction ring; a groove is formed in one side, far away from the first side face, of the butt strap, an attraction block is arranged in the groove and made of a magnet, and the isolating piece is made of a magnetic material.

8. The method as claimed in claim 7, wherein the opening and closing door comprises a door body and an extension edge surrounding the door body, the extension edge is made of a magnet, the peripheral wall of the pulverization chamber is made of a magnetic material, the peripheral wall of the pulverization chamber is provided with a plurality of insertion openings corresponding to the chamber body one by one, one of the insertion openings is inserted into one of the door bodies, and the extension edge is attached to the edge of the insertion opening.

9. The method for preparing a medicament for rapidly removing onychomycosis according to any one of claims 5 to 8, wherein the soaking in step one is performed using a soaker, the soaker comprises a barrel, a magnet, an electromagnet and an elastic support base, the barrel is placed on the elastic support base, the electromagnet is installed below the barrel, and the magnet is provided at the bottom of the barrel corresponding to the position of the electromagnet.

10. The method of claim 9, wherein the resilient support comprises a frame, a base, and a plurality of springs disposed between the frame and the base, the electromagnet is disposed on the base, the frame is disposed above the base, and the barrel is disposed on the frame.