CN104921221B - A kind of YIGANCAO plant beverage - Google Patents
A kind of YIGANCAO plant beverage Download PDFInfo
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- CN104921221B CN104921221B CN201510303774.6A CN201510303774A CN104921221B CN 104921221 B CN104921221 B CN 104921221B CN 201510303774 A CN201510303774 A CN 201510303774A CN 104921221 B CN104921221 B CN 104921221B
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- yigancao
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- 235000013361 beverage Nutrition 0.000 title claims abstract description 18
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 3
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000000605 extraction Methods 0.000 claims description 10
- 238000005520 cutting process Methods 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 239000005913 Maltodextrin Substances 0.000 claims description 5
- 229920002774 Maltodextrin Polymers 0.000 claims description 5
- 229940035034 maltodextrin Drugs 0.000 claims description 5
- 239000004382 Amylase Substances 0.000 claims description 4
- 102000013142 Amylases Human genes 0.000 claims description 4
- 108010065511 Amylases Proteins 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 235000019418 amylase Nutrition 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 235000021050 feed intake Nutrition 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 99
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 abstract description 32
- 230000000694 effects Effects 0.000 abstract description 31
- 230000002075 anti-alcohol Effects 0.000 abstract description 18
- 210000004185 liver Anatomy 0.000 abstract description 11
- 238000002360 preparation method Methods 0.000 abstract description 6
- 238000001514 detection method Methods 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 2
- 230000001681 protective effect Effects 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 23
- 239000000047 product Substances 0.000 description 21
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 20
- 210000002966 serum Anatomy 0.000 description 20
- 241000196324 Embryophyta Species 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 230000035622 drinking Effects 0.000 description 9
- 239000007789 gas Substances 0.000 description 8
- 238000003304 gavage Methods 0.000 description 8
- 102000019197 Superoxide Dismutase Human genes 0.000 description 7
- 108010012715 Superoxide dismutase Proteins 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 101710088194 Dehydrogenase Proteins 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 102000016938 Catalase Human genes 0.000 description 5
- 108010053835 Catalase Proteins 0.000 description 5
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
- 239000007910 chewable tablet Substances 0.000 description 4
- 229940068682 chewable tablet Drugs 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 238000003988 headspace gas chromatography Methods 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 240000006394 Sorghum bicolor Species 0.000 description 2
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000012159 carrier gas Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 239000011229 interlayer Substances 0.000 description 2
- 238000012417 linear regression Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 1
- -1 Adenosine triphosphate Glycosides Chemical class 0.000 description 1
- 208000005584 Alcoholic Intoxication Diseases 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010009192 Circulatory collapse Diseases 0.000 description 1
- 244000111489 Gardenia augusta Species 0.000 description 1
- 235000018958 Gardenia augusta Nutrition 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 108010070675 Glutathione transferase Proteins 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 description 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 238000010802 RNA extraction kit Methods 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical class [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 208000002353 alcoholic hepatitis Diseases 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000001034 respiratory center Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
A kind of YIGANCAO plant beverage, and preparation method thereof, produce equipment, application, and relieve the effect of alcohol and the assessment method of liver protective effect, the compositions such as product contains: Folium Ilicis, Radix Puerariae, Fructus Gardeniae, Herba Houttuyniae, Herba Taraxaci, Fructus Lycii, Fructus Jujubae, Radix Glycyrrhizae.By gas chromatogram, the detection of ethanol, acetaldehyde is confirmed that this product Antialcoholic liver-protecting effect is better than like product.
Description
Technical field
The present invention relates to field of food, be a kind of Antialcoholic liver-protecting plant beverage, Preparation equipment, preparation technology, application, and
The assay method of Antialcoholic liver-protecting effect.
Background technology
Wine is a kind of beverage the most common during people live, and a lot of people have alcohol drinking patterns.Responsible drinking has one to health
Fixed benefit, but, health will be caused burden greatly by excessive consumption of alcohol, and the most common a kind of situation is exactly drunk.Drunk
After being excessive consumption of alcohol, uncomfortable, a kind of state of insobriety, and also this state can continue for some time, greatly
Affect orthobiosis and work.Drunk be because drinking into ethanol about four/ for a moment directly absorbed by stomach, can draw after absorption
The telangiectasis playing coat of the stomach makes people have the sensation having enough, and meanwhile, affects the normal creepage of gastrointestinal functions of stomach, causes the generation of vomiting.Its
Remaining ethanol carries out biological metabolism in liver, makes ethanol be converted into acetaldehyde, is then converted into acetic acid, is finally decomposed to Adenosine triphosphate
Glycosides, water and carbon dioxide.After excessive consumption of alcohol, liver needs longer time decomposition ethanol, and acetaldehyde has directly danger to hepatocyte
Evil.
Disintoxicating product arises at the historic moment, and the most famous is with the sea Wang Jin cup product that relieves the effect of alcohol prepared based on animal as representative
Product, and much based on plant, utilize disintoxicating product prepared by China's Traditional Chinese medical theory, especially the latter, of a great variety, warp
The Chinese crude drug often used includes food that Radix Puerariae, Flos Lonicerae and sugar content are higher or directly adds glucide.Radix Puerariae gold
Flos Lonicerae is all cool property medicine, and saccharide can alleviate the problem of low sugar after drinking, thus alleviates the most various symptoms.But for glycosuria
Patient, sugary higher product is inapplicable, and meanwhile, empty or other symptom the patient of body is also not suitable for too much taking cool in nature
Chinese medicine.Further, the antialcoholic drug on market often judges dispelling effects of alcohol according to the relieving alcoholic intoxication time, and subjective factors impact is relatively big, institute
With to this series products inadequate science of effect Test Assessment Mechanism, accurately.
After ethanol enters human body, being metabolized into acetaldehyde, acetaldehyde is metabolized into acetic acid further.Internal ethanol too much can cause
Respiratory center paralysis, circulatory failure even result in death, simultaneously it is also possible to cause acute alcoholic hepatitis and gastritis etc..Second
Aldehyde is then the main cause causing alcoholic liver injury.Detect ethanol in blood, acetaldehyde after drinking, to investigating Chinese medicinal alcoholism-relieving
The antialcoholism action of medicine has extremely important meaning.
Ethanol dehydrogenase is the Major Enzymes of alcohol metabolism, catalase, glutathione S-transferase, superoxides discrimination
Change the enzyme that enzyme is three kinds of most important cleaning free radicals, measure the activity of these five kinds of enzymes, protect the liver inquiring into medicament for sobering up and protecting liver
Effect and protect the liver mechanism and have important meaning.
Summary of the invention
The plant beverage of Antialcoholic liver-protecting of the present invention is based on ethnic groups medical herbs handed down from one's ancestors ancient prescription, and constantly research is opened
Send out, in conjunction with Seedling ridge natural herbs as a kind of plant beverage of feed purification, and add on the basis of conventional formulation
Having added Radix Puerariae and Folium Ilicis, Radix Puerariae sweet in the mouth, pungent, property is put down, and returns spleen, stomach, lung, bladder warp.Expelling pathogenic factors from muscles for reducing heat；Deliver and examine；Only promote the production of body fluid
Yearningly；Yang invigorating antidiarrheal, can well substitute glucide and alleviate drunk symptom, and Folium Ilicis bitter in the mouth is put down, and itself is to disappear simply
The Chinese medicine of expectorant diuresis, is rarely used in and relieves the effect of alcohol, but in the present invention, regulation Folium Ilicis and the ratio of Radix Puerariae, for dispelling effects of alcohol
But playing an important role, after adding special ratios Folium Ilicis and Radix Puerariae, product dispelling effects of alcohol improves by about one time.Except this it
Outward, Preparation equipment selects tubulation circulating extraction, programming rate is greatly improved, such that it is able to cold water and medicine are added simultaneously
Enter, heat, contribute to extracting more active component, it is also possible to inhibitory enzyme decomposition to active component when low temperature,
This also makes the dispelling effects of alcohol of product obtain significant raising, and the product prepared compared to legacy equipment disc type extraction pot relieves the effect of alcohol effect
Fruit improves about 30%, and extraction ratio improves about 10%, and the most energy-conservation about 50%.Except antialcoholism function, the present invention also has and dispels
Fire skin care, the function of hepatoprotective.
For solving the problems referred to above, the technical solution adopted in the present invention is:
Its active component is made up of the component of following weight proportioning: Folium Ilicis 0.15 ~ 0.2%, Radix Puerariae 0.1 ~ 0.2%, Cape jasmine
Son 0.2 ~ 0.4%, Herba Houttuyniae 0.2 ~ 0.4%, Herba Taraxaci 0.2 ~ 0.4%, Fructus Lycii 0.1 ~ 0.2%, Fructus Jujubae 0.05 ~ 0.2%, Radix Glycyrrhizae
0.01 ~ 0.1%, maltodextrin 0 ~ 0.4%, Mel 0 ~ 0.4%, remaining is water, wherein Fructus Gardeniae, for little Yellow Fructus Gardeniae, through parch, removes
Use after bitter taste.
Weigh Folium Ilicis, Radix Puerariae, Fructus Gardeniae, Herba Houttuyniae, Herba Taraxaci, Fructus Lycii, Fructus Jujubae, Radix Glycyrrhizae by said ratio, it is entered
Row cleans, cutting, puts into shell and tube circulating extraction, adds cold water, opening clamp layered heating, be rapidly heated while feeding intake
90 DEG C, keep 30 minutes at this temperature, extracting solution after fine straining, fill, sterilizing, cool down, pack, product inspection, warehouse-in.Its
In, extraction pot is placed in parallel multiple pipeline for extracting solution flowing, the outer sandwich establishment heater of pipeline, add for liquid in pipeline
Heat.
Solid material cleans and selectively adds maltodextrin and Mel lifting mouthfeel, selectivity after extracting solution fine straining after cutting off
Add enzyme clarifier, gelatin, chitosan, polyvinylpyrrolidone, kieselguhr, a kind or several in ZTC1+1 clarifier, disappear
Except the muddy thing in YIGANCAO plant beverage.Wherein, enzyme clarifier is pectase, amylase, the combination of saccharifying enzyme.
Before drinking, drink in, drink after take, within before especially drinking 20 ~ 40 minutes, take product of the present invention, permissible
Substantially alleviate the most common gastrointestinal upset, xerostomia, feel sick, headache, tired, palpitating speed, anorexia, dizzy symptom,
Significantly shorten the drunk time.Inventor is by the artificial serologic test filling wine mice, it was demonstrated that, Antialcoholic liver-protecting medicine of the present invention can
Significantly reducing the ethanol in mice serum, acetaldehyde, have good dispelling effects of alcohol, in serum, ethanol content is not take
During any medicine 1/20, is take other type antialcoholic drug 1/10；When in serum, acetaldehyde is not take any medicine
1/3, be take other type antialcoholic drug 1/4.Dispelling effects of alcohol does not add Radix Puerariae than previous generation and Folium Ilicis product exceeds
About one times, but if removing Radix Puerariae, dispelling effects of alcohol and previous generation product maintain an equal level, if removing Folium Ilicis, retaining Radix Puerariae, solving
Wine effect is slightly better than ratio previous generation product.Inventor removes other raw material respectively, finds that product effect significantly decays, especially fish
Raw meat grass, Herba Taraxaci and Fructus Gardeniae, remove wherein any one, dispelling effects of alcohol all can decline 1 ~ 4 times；And remove Radix Glycyrrhizae, Fructus Lycii and
The impact of the Fructus Jujubae effect on relieving the effect of alcohol is weaker than Herba Houttuyniae, Herba Taraxaci and Fructus Gardeniae, but the effect of product also can be made to be decreased obviously.With
Time, to add all raw materials of the present invention, but use proportioning beyond herein described scope, dispelling effects of alcohol decay is also ten clearly demarcated
Aobvious, as added more Radix Puerariae, Herba Taraxaci, Fructus Gardeniae, Herba Houttuyniae, products taste declines, and dispelling effects of alcohol also has downward trend simultaneously；
Adding more Folium Ilicis, dispelling effects of alcohol starts slightly to decline, and if the Folium Ilicis added is less than herein described scope, then
Dispelling effects of alcohol starts significantly to decay.Antialcoholic liver-protecting medical instrument of the present invention has good liver protective effect, in the mouse liver of above-mentioned experiment
When ethanol dehydrogenase and superoxide dismutase are not take any medicine respectively 1.5 ~ 2 times, superoxide dismutase is clothes
With 2 times of other type antialcoholic drug.
After ethanol enters liver, metabolism generates acetaldehyde, generates a large amount of free radical, produces toxicity.Test result indicate that: this
Invention Antialcoholic liver-protecting medicine can significantly reduce the content of ethanol in mice serum, acetaldehyde, illustrates it to have significantly to relieve the effect of alcohol work
With.The by-product H produced during alcohol metabolism2O2Center of Superoxide Dismutase metal-complexing field can be destroyed, cause
Enzyme is impaired.Catalase can be catalyzed H2O2It is changed into H2O and O2.Test result indicate that: Antialcoholic liver-protecting medicine of the present invention can improve
Ethanol dehydrogenase, superoxide dismutase, catalatic activity, illustrate that it has removing free radical, reduces alcohol metabolism
Effect to hepar damnification.
Accompanying drawing explanation
Fig. 1 is present invention process flow chart.
Fig. 2 is present invention gas chromatogram of ethanol standard substance when measuring ethanol in blood content.
Fig. 3 is present invention gas chromatogram of blank plasma when measuring ethanol in blood content.
Fig. 4 is present invention target gas chromatogram in butanone when measuring ethanol in blood content.
Fig. 5 is present invention gas chromatogram of blood serum sample when measuring ethanol in blood content.
Fig. 6 is present invention gas chromatogram of acetaldehyde standard substance when measuring acetaldehyde in blood.
Fig. 7 is present invention gas chromatogram of blank plasma when measuring acetaldehyde in blood.
Fig. 8 is present invention target gas chromatogram in butanone when measuring acetaldehyde in blood.
Fig. 9 is present invention gas chromatogram of blood serum sample when measuring acetaldehyde in blood.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the invention will be further described.
Detailed description of the invention one: selected Folium Ilicis 1.6 Kg, Radix Puerariae 1.6 Kg, Fructus Gardeniae 3.2 Kg, Herba Houttuyniae 3.2 Kg,
Herba Taraxaci 3.2 Kg, Fructus Lycii 1.6 Kg, Fructus Jujubae 1.0 Kg, Radix Glycyrrhizae 0.5 Kg, be carried out it, cutting, puts into shell and tube
Circulating extraction, adds cold water 984.1 Kg, opening clamp layered heating, is rapidly heated 90 DEG C, in this temperature while feeding intake
Lower holding 30 minutes, extracting solution after fine straining, fill, sterilizing, cool down, pack, product inspection, warehouse-in.
Detailed description of the invention two: selected Folium Ilicis 1.6 Kg, Radix Puerariae 1.6 Kg, Fructus Gardeniae 3.2 Kg, Herba Houttuyniae 3.2 Kg,
Herba Taraxaci 3.2 Kg, Fructus Lycii 1.6 Kg, Fructus Jujubae 1.0 Kg, Radix Glycyrrhizae 0.5 Kg, be carried out it, cutting, puts into shell and tube
Circulating extraction, adds maltodextrin 2.5 Kg, Mel 2.5 Kg, cold water 979.1 Kg while feeding intake, open interlayer and add
Hot device, is rapidly heated 90 DEG C, keeps 30 minutes at this temperature, extracting solution after fine straining, fill, sterilizing, cool down, pack,
Product inspection, warehouse-in.
Detailed description of the invention three: selected Folium Ilicis 1.6 Kg, Radix Puerariae 1.6 Kg, Fructus Gardeniae 3.2 Kg, Herba Houttuyniae 3.2 Kg,
Herba Taraxaci 3.2 Kg, Fructus Lycii 1.6 Kg, Fructus Jujubae 1.0 Kg, Radix Glycyrrhizae 0.5 Kg, be carried out it, cutting, puts into shell and tube
Circulating extraction, adds cold water 984.1 Kg, opening clamp layered heating, is rapidly heated 90 DEG C, in this temperature while feeding intake
Lower holding 30 minutes, extracting solution adds pectase, amylase, saccharifying enzyme, gelatin, chitosan, polyvinylpyrrolidine after fine straining
Ketone, kieselguhr, ZTC1+1 clarifier, fill, sterilizing, cool down, pack, product inspection, warehouse-in.
Detailed description of the invention four: selected Folium Ilicis 1.6 Kg, Radix Puerariae 1.6 Kg, Fructus Gardeniae 3.2 Kg, Herba Houttuyniae 3.2 Kg,
Herba Taraxaci 3.2 Kg, Fructus Lycii 1.6 Kg, Fructus Jujubae 1.0 Kg, Radix Glycyrrhizae 0.5 Kg, be carried out it, cutting, puts into shell and tube
Circulating extraction, adds maltodextrin 2.5 Kg, Mel 2.5 Kg, cold water 979.1 Kg while feeding intake, open interlayer and add
Hot device, is rapidly heated 90 DEG C, keeps 30 minutes at this temperature, and extracting solution adds pectase, amylase, saccharifying after fine straining
Enzyme, gelatin, chitosan, polyvinylpyrrolidone, kieselguhr, fill, sterilizing, cool down, pack, product inspection, warehouse-in.
Detailed description of the invention five: animal is grouped: mice is randomly divided into 3 groups, blank group, other antialcoholic drug group, the present invention
YIGANCAO plant beverage group, often group 10.Gastric infusion: each group by body weight gastric infusion, blank group gavage distilled water, its
Its antialcoholic drug group group gavage " clear-headed chewable tablet ", YIGANCAO plant beverage group gavage YIGANCAO of the present invention plant beverage of the present invention,
Press 0.15ml/10g gavage Red Star strong, colourless liquor distilled from sorghum after being administered 30 minutes, give and within 1.5 hours after drinking, carry out mice and pluck eyeball and take blood, 37
DEG C hatching 30 minutes, 3000r is centrifuged 10min, separates serum, and-20 DEG C of Refrigerator stores are stand-by.
Alcohol determining condition, chromatographic column: Cp-Wax52CB；Injector temperature: 80 DEG C；Incubation temperature: 80 DEG C；Carrier gas stream
Speed: 100.0ul/Sec；Incubation time: 15 min；Temperature programming: initial temperature 30 DEG C, stops 4min；20 DEG C/min liter
To 40 DEG C, stop 1min；After rise to 150 DEG C with 30 DEG C/min, stop 1min；Total time 14.67min.
Iso-propyl alcohol condition, chromatographic column: Cpsil5CB-2；Injector temperature: 80 DEG C；Incubation temperature: 80 DEG C；Carrier gas stream
Speed: 100.0ul/Sec；Incubation time: 15 min；Temperature programming: initial temperature 30 DEG C, stops 4min；20 DEG C/min liter
To 40 DEG C, stop 1min；After rise to 150 DEG C with 30 DEG C/min, stop 1min；Total time 14.67min.
The mensuration of ethanol content in serum, the preparation of standard curve: accurately measure concentration be 0.8mg/ml, 0.4mg/ml,
The each 1ml of ethanol titer of 0.2mg/ml, 0.1mg/ml, 0.5mg/ml, 0.01mg/ml, 0.005mg/ml adds in ml headspace bottle,
Measuring 0.1ml blank serum in ml headspace bottle with liquid-transfering gun the most respectively, cover bottle cap, pressure bottle opener compresses.According to chromatographic condition
Carrying out headspace gas chromatography detection, record the ratio of gained ethanol and the peak area of butanone, linear regression obtains standard curve.Reclaim
Rate: accurately measure in 5ml ethanol storing solution, 1.5ml butanone storing solution A to 10ml volumetric flask, be titrated to scale, obtain ethanol dense
Degree is the solution C of 1.5ug for 0.5mg/ml, butanone concentration, measures 1ml solution C and adds 0.1ml blank serum in ml headspace bottle,
Cover compression bottle cap, measure concentration of alcohol.Repeat to make six samples.Repeatability and precision: the same sample of replication six
Secondary.Minimum detectability: according to standard curve determination result, the ethanol titer of measured amounts, adds blank serum, constantly
Reduce ethanol standard liquid measure, until signal to noise ratio is 3:1.Sample size measures: pipette blood serum sample 0.1 ml molten with butanone standard
Liquid (C reagent) 1 ml, in ml headspace bottle, carries out headspace gas chromatography detection according to chromatographic condition, records gained blood serum sample second
Alcohol and the ratio of the peak area of butanone, according to standard curve, calculate the concentration of ethanol in serum.
The mensuration of acetaldehyde in serum.The preparation of standard curve: accurately measure concentration be 10ug/ml, 5ug/ml,
The acetaldehyde titer 1ml of 4ug/ml, 2ug/ml, 1ug/ml, 0.5ug/ml adds in ml headspace bottle, uses liquid-transfering gun amount the most respectively
Taking 0.1ml blank serum in ml headspace bottle, cover bottle cap, pressure bottle opener compresses.Headspace gas chromatography is carried out according to chromatographic condition
Detection, records the ratio of gained ethanol and the peak area of butanone, and linear regression obtains standard curve.The response rate: measuring concentration is
The ethanol 1ml of 10ug/ml, in ml headspace bottle, adds 0.1ml blank serum, covers compression bottle cap, measures concentration of alcohol.Weight
Make six samples again.Repeatability and precision: the same sample of replication six times.Minimum detectability: survey according to standard curve
Determine result, the acetaldehyde titer of measured amounts, add blank serum, constantly reduce ethanol standard liquid measure, until signal to noise ratio is
3:1.Sample size measures: pipette blood serum sample 0.1 ml and butanone standard solution (C reagent) 1 ml in ml headspace bottle, according to
Chromatographic condition carries out headspace gas chromatography detection, records the ratio of gained whole blood sample acetaldehyde and the peak area of butanone, according to standard
Curve, calculates the concentration of acetaldehyde in serum.
Test result is as follows:
| Ethanol (mg/mL) | Acetaldehyde (ug/mL) | |
| Blank group | 2.14±0.8 | 32.34±14.15 |
| Other antialcoholic drug group (clear-headed chewable tablet) | 0.98±0.64 | 43.24±17.68 |
| YIGANCAO plant beverage group of the present invention | 0.09±0.12 | 9.30±9.86 |
Detailed description of the invention six: ethanol dehydrogenase, catalase, the active testing of superoxide dismutase: mice with
Machine is divided into 3 groups: blank group, other antialcoholic drug group, YIGANCAO plant beverage group of the present invention, often group 10.Gastric infusion: each group
By body weight gastric infusion, blank group gavage distilled water, other antialcoholic drug group group gavage " clear-headed chewable tablet ", YIGANCAO of the present invention is planted
Thing beverage group gavage YIGANCAO of the present invention plant beverage, presses 0.15ml/10g gavage Red Star strong, colourless liquor distilled from sorghum, gives after being administered 30 minutes
Within 1.5 hours after drinking, cervical vertebra is drawn to put to death.Weigh liver and add normal saline and make 10% homogenate.RNA isolation kit measures Mouse Liver
Ethanol dehydrogenase in dirty tissue, catalase, the activity of superoxide dismutase.
Test result is as follows:
| Ethanol dehydrogenase (U/mgprot) | Catalase (U/mgprot) | Superoxide dismutase (U/mgprot) | |
| Blank group | 66.65±45.83 | 65.26±19. 27 | 94.39±42.77 |
| Other antialcoholic drug group (clear-headed chewable tablet) | 70.73±33.42 | 36.05±15.17 | 142.05±67. 40 |
| YIGANCAO plant beverage group of the present invention | 101.25±31.98 | 70.57±18.76 | 213.03±36.65 |
Claims (1)
1. a YIGANCAO plant beverage, it is characterised in that described beverage uses following weight proportion and technique to be prepared from: right
The Folium Ilicis of 1.6 Kg, the Radix Puerariae of 1.6 Kg, the Fructus Gardeniae of 3.2 Kg, the Herba Houttuyniae of 3.2 Kg, the Herba Taraxaci of 3.2 Kg, 1.6 Kg
The Radix Glycyrrhizae of Fructus Lycii, the Fructus Jujubae of 1.0 Kg and 0.5 Kg be carried out and cutting, put into shell and tube circulating extraction, feed intake
It is simultaneously introduced maltodextrin 2.5 Kg, Mel 2.5 Kg and cold water 979.1 Kg, opening clamp layered heating, is rapidly heated 90
DEG C, keeping 30 minutes at this temperature, extracting solution adds pectase, amylase, saccharifying enzyme, gelatin, chitosan after fine straining, gathers
Vinylpyrrolidone, kieselguhr, and form through fill, sterilizing, cooling.
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| CN105519739A (en) * | 2016-01-06 | 2016-04-27 | 陈志华 | Refreshing alcohol-dispelling detoxifying healthy health-preserving cold tea |
| CN105901222A (en) * | 2016-04-25 | 2016-08-31 | 陈志华 | Formula of alcohol effect-alleviating toxin-expelling herbal tea |
| CN107345944B (en) * | 2016-05-04 | 2019-05-07 | 中国石油天然气股份有限公司 | A kind of method of acetaldehyde in measurement liquid phase mixture |
| CN107087734A (en) * | 2017-03-16 | 2017-08-25 | 广西玉林制药集团有限责任公司 | A kind of health composition of appetite-stimulating indigestion-relieving, beverage and preparation method thereof |
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Denomination of invention: Liver tonifying herbaceous plant beverage Effective date of registration: 20161214 Granted publication date: 20161102 Pledgee: Guiding County Rural Credit Cooperatives Pledgor: GUIZHOU MIAOGULIANG FOOD CO., LTD. Registration number: 2016990001106 |
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Denomination of invention: Liver tonifying herbaceous plant beverage Effective date of registration: 20191010 Granted publication date: 20161102 Pledgee: Guiding rural credit cooperative association|Guizhou Duyun Rural Commercial Bank Co., Ltd.|Guizhou Dushan Rural Commercial Bank Co., Ltd.|Guizhou Pingtang Rural Commercial Bank Co., Ltd.|Guizhou Sandu Rural Commercial Bank Co., Ltd.|Guizhou Longli Rural Commercial Bank Co., Ltd.|Guizhou Huishui Rural Commercial Bank Co., Ltd.|Changshun rural credit Cooperative association|Luodian Rural Credit Cooperative Association Pledgor: GUIZHOU MIAOGULIANG FOOD CO., LTD. Registration number: Y2019990000312 |