CN104921221A - Liver tonifying herbaceous plant beverage - Google Patents
Liver tonifying herbaceous plant beverage Download PDFInfo
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- CN104921221A CN104921221A CN201510303774.6A CN201510303774A CN104921221A CN 104921221 A CN104921221 A CN 104921221A CN 201510303774 A CN201510303774 A CN 201510303774A CN 104921221 A CN104921221 A CN 104921221A
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- 210000004185 liver Anatomy 0.000 title claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 88
- 241000196324 Embryophyta Species 0.000 claims abstract description 28
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 15
- 235000018958 Gardenia augusta Nutrition 0.000 claims abstract description 15
- 240000000691 Houttuynia cordata Species 0.000 claims abstract description 13
- 244000241872 Lycium chinense Species 0.000 claims abstract description 11
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 11
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 11
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 claims abstract description 6
- 238000004817 gas chromatography Methods 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims description 45
- 239000003814 drug Substances 0.000 claims description 27
- 230000002075 anti-alcohol Effects 0.000 claims description 21
- 210000002966 serum Anatomy 0.000 claims description 21
- 244000046146 Pueraria lobata Species 0.000 claims description 19
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 19
- 244000078118 Ilex latifolia Species 0.000 claims description 18
- 235000008706 Ilex latifolia Nutrition 0.000 claims description 18
- 230000035622 drinking Effects 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
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- 238000000605 extraction Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 7
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 7
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- 102000013142 Amylases Human genes 0.000 claims description 4
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 240000006394 Sorghum bicolor Species 0.000 claims description 4
- 235000011684 Sorghum saccharatum Nutrition 0.000 claims description 4
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- 240000008917 Glycyrrhiza uralensis Species 0.000 abstract 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 abstract 1
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- 241000209035 Ilex Species 0.000 abstract 1
- 235000003332 Ilex aquifolium Nutrition 0.000 abstract 1
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- 235000002294 Ilex volkensiana Nutrition 0.000 abstract 1
- 241000292546 Taraxacum mongolicum Species 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 34
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 20
- 239000007789 gas Substances 0.000 description 8
- 230000004060 metabolic process Effects 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
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- 208000007848 Alcoholism Diseases 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
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- 206010019728 Hepatitis alcoholic Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
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- 238000010521 absorption reaction Methods 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
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- 231100000753 hepatic injury Toxicity 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
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- 208000026435 phlegm Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a liver tonifying herbaceous plant beverage and a preparation method, a production equipment, an application, and an evaluation method of alcohol dispelling and liver protecting effects thereof. The product contains the following components: broadleaf holly leaves, radix puerariae, gardenia jasminoides, houttuynia cordata, taraxacum mongolicum, Chinese wolfberry fruits, Chinese dates, glycyrrhiza uralensis, etc. By the gas chromatography detection of ethanol and acetaldehyde, the herbaceous plant beverage is confirmed to have superior alcohol dispelling and liver protecting effects than similar products.
Description
Technical field
The present invention relates to field of food, is a kind of Antialcoholic liver-protecting plant beverage, Preparation equipment, preparation technology, application, and the assay method of Antialcoholic liver-protecting effect.
Background technology
Wine is a kind of beverage very common during people live, and a lot of people has alcohol drinking patterns.Responsible drinking has certain benefit to health, but excessive consumption of alcohol will cause great burden to health, and very common a kind of situation is exactly drunk.Drunk is after excessive consumption of alcohol, uncomfortable, a kind of state of insobriety, and this state can continue for some time, and affects normal life and work greatly.Drunk be because drink into alcohol about four/ directly absorbed by stomach for a moment, the sensation that can cause the telangiectasis of coat of the stomach that people is had after absorption to have enough, meanwhile, affect the normal creepage of gastrointestinal functions of stomach, causes the generation of vomiting.Remaining alcohol carries out biological metabolism in liver, makes alcohol be converted into acetaldehyde, then changes into acetic acid, is finally decomposed into atriphos, water and carbon dioxide.After excessive consumption of alcohol, liver needs the time decomposition alcohol more grown, and acetaldehyde has direct harm to liver cell.
Disintoxicating product arises at the historic moment, the disintoxicating product prepared based on animal that comparatively famous is is representative with extra large Wang Jin cup, and it is a lot of based on plant, utilize disintoxicating product prepared by China's Traditional Chinese medical theory, especially the latter, of a great variety, the Chinese medicine often used comprises the root of kudzu vine, honeysuckle and the higher food of sugar content or directly add glucide.Root of kudzu vine gold and silver Huadu is cool property medicine, and carbohydrate can alleviate the problem of low sugar after drinking, thus alleviates various symptom after drinking.But for diabetic, sugary higher product is inapplicable, meanwhile, body patient that is empty or other symptom is also not suitable for too much taking Chinese medicine cool in nature.Further, the antialcoholic drug on market often judges to relieve the effect of alcohol effect according to the time of sobering up, and subjective factor impact is comparatively large, so to the inadequate science of this series products effect Test Assessment Mechanism, accurately.
After ethanol enters human body, metabolism becomes acetaldehyde, and the further metabolism of acetaldehyde becomes acetic acid.In body, ethanol too much can cause that respiratory center is benumbed, circulatory failure even causes death, also likely causes acute alcoholic hepatitis and gastritis etc. simultaneously.Acetaldehyde is then the main cause causing alcoholic liver injury.Detect ethanol in blood, acetaldehyde after drinking, have extremely important meaning to the antialcoholism action investigating Chinese medicinal alcoholism-relieving medicine.
Alcohol dehydrogenase is the Major Enzymes of alcohol metabolism, catalase, glutathione S-transferase, superoxide dismutase are the enzymes of three kinds of most important cleaning free radicals, measure the activity of these five kinds of enzymes, to inquiring into the liver protective effect of medicament for sobering up and protecting liver and protecting the liver mechanism and have important meaning.
Summary of the invention
The plant beverage of Antialcoholic liver-protecting of the present invention is based on ethnic group's herbal medicine ancient prescription handed down from one's ancestors, continuous research and development, in conjunction with a kind of plant beverage of seedling ridge natural herbs as feed purification, and the root of kudzu vine and Ilex Latifolia Thunb is with the addition of on the basis of conventional formulation, root of kudzu vine taste is sweet, pungent, property is put down, and returns spleen, stomach, lung, urinary bladder channel.Relieving muscles to expel heat; Deliver and examine; Promote the production of body fluid to quench thirst; Rise positive antidiarrheal, glucide can well be substituted and alleviate drunk symptom, and Ilex Latifolia Thunb bitter is put down, itself be the Chinese medicine of dispelling phlegm to promote diupesis simply, be rarely used in and relieve the effect of alcohol, but in the present invention, regulate the ratio of Ilex Latifolia Thunb and the root of kudzu vine, for relieving the effect of alcohol, effect but plays an important role, after adding special ratios Ilex Latifolia Thunb and the root of kudzu vine, product relieve the effect of alcohol effect improve nearly one times.In addition, Preparation equipment selects tubulation circulating extraction, significantly improves programming rate, thus cold water and medicine can be added simultaneously, heat, contribute to extract more active components, meanwhile, also can inhibitory enzyme when low temperature to the decomposition of active component, this also makes the effect of relieving the effect of alcohol of product obtain significant raising, the product prepared compared to legacy equipment disc type extractor effect of relieving the effect of alcohol improves about 30%, and recovery rate improves about 10%, and simultaneously energy-conservation about 50%.Except antialcoholism function, the present invention also has fiery beauty treatment of dispelling, the function of liver protecting.
For solving the problem, the technical solution adopted in the present invention is:
Its active component is made up of the component of following weight proportioning: Ilex Latifolia Thunb 0.15 ~ 0.2%, the root of kudzu vine 0.1 ~ 0.2%, cape jasmine 0.2 ~ 0.4%, cordate houttuynia 0.2 ~ 0.4%, dandelion 0.2 ~ 0.4%, the fruit of Chinese wolfberry 0.1 ~ 0.2%, date 0.05 ~ 0.2%, Radix Glycyrrhizae 0.01 ~ 0.1%, maltodextrin 0 ~ 0.4%, honey 0 ~ 0.4%, all the other are water, wherein cape jasmine, are little Yellow Fructus Gardeniae, through frying, use after removing bitter taste.
Ilex Latifolia Thunb is taken, the root of kudzu vine, cape jasmine by said ratio, cordate houttuynia, dandelion, the fruit of Chinese wolfberry, date, Radix Glycyrrhizae, cleans it, segment, drops into shell and tube circulating extraction, adds cold water while feeding intake, opening clamp layered heating, is rapidly heated 90 DEG C, keeps 30 minutes at this temperature, extract after essence filter, filling, sterilizing, cooling, packaging, product inspection, warehouse-in.Wherein, the multiple pipeline for extract flowing of parallel placement in extractor, the outer sandwich establishment heater of pipeline is heating liquid in pipeline.
Solid material is selective after cleaning and cutting off adds maltodextrin and honey lifting mouthfeel, and extract essence is selective after filtering adds enzyme fining agent, gelatin, shitosan, polyvinylpyrrolidone, diatomite, 1 kind in ZTC1+1 fining agent or several, eliminate the muddy thing in YIGANCAO plant beverage.Wherein, enzyme fining agent is pectase, amylase, the combination of carbohydrase.
Before drinking, drink in, drink after take, especially within before drinking 20 ~ 40 minutes, product of the present invention is taken, obviously can alleviate upset,gastro-intestinal common after drinking, dry, feel sick, headache, tired, palpitating speed, apocleisis, dizzy symptom, significantly shorten the drunk time.Inventor is by the serologic test to artificial filling wine mouse, prove, Antialcoholic liver-protecting medicine of the present invention significantly can reduce ethanol, acetaldehyde in mice serum, there is good effect of relieving the effect of alcohol, in serum, ethanol content is 1/20 when not taking any medicine, is take other type antialcoholic drug 1/10; In serum, acetaldehyde is 1/3 when not taking any medicine, is take other type antialcoholic drug 1/4.Effect of relieving the effect of alcohol does not add the root of kudzu vine than previous generation and Ilex Latifolia Thunb product exceeds about one times, but if remove the root of kudzu vine, effect of relieving the effect of alcohol and previous generation product maintain an equal level, if remove Ilex Latifolia Thunb, retain the root of kudzu vine, effect of relieving the effect of alcohol slightly is better than than previous generation product.Inventor removes other raw material respectively, finds that product effect significantly decays, especially cordate houttuynia, dandelion and cape jasmine, removing wherein any one, effect of relieving the effect of alcohol all can decline 1 ~ 4 times; And remove the impact on the effect of relieving the effect of alcohol of Radix Glycyrrhizae, the fruit of Chinese wolfberry and date and be weaker than cordate houttuynia, dandelion and cape jasmine, but the successful of product also can be made to decline.Meanwhile, add all raw materials of the present invention, but use proportioning to exceed scope described in the application, effect of relieving the effect of alcohol decay is also fairly obvious, and as added the more root of kudzu vine, dandelion, cape jasmine, cordate houttuynia, products taste declines, and effect of simultaneously relieving the effect of alcohol also has downward trend; Add more Ilex Latifolia Thunb, effect of relieving the effect of alcohol starts small size decline, and if add Ilex Latifolia Thunb lower than scope described in the application, then effect of relieving the effect of alcohol starts significantly to decay.Antialcoholic liver-protecting medical instrument of the present invention has good liver protective effect, and in the mouse liver of above-mentioned experiment, alcohol dehydrogenase and superoxide dismutase are 1.5 ~ 2 times when not taking any medicine respectively, and superoxide dismutase is 2 times that take other type antialcoholic drug.
After ethanol enters liver, metabolism generates acetaldehyde, generates a large amount of free radical, produces toxicity.Experimental result shows: Antialcoholic liver-protecting medicine of the present invention significantly can reduce the content of ethanol in mice serum, acetaldehyde, illustrates that it has significant antialcoholism action.The accessory substance H produced in alcohol metabolism process
2o
2center of Superoxide Dismutase metal-complexing field can be destroyed, cause enzyme impaired.Catalase energy catalysis H
2o
2change H into
2o and O
2.Experimental result shows: Antialcoholic liver-protecting medicine of the present invention can improve alcohol dehydrogenase, superoxide dismutase, catalatic activity, illustrates that it has scavenging free radicals, reduces alcohol metabolism to the effect of hepar damnification.
Accompanying drawing explanation
Fig. 1 is present invention process flow chart.
Fig. 2 is the gas chromatogram of the present invention's ethanol standard items when measuring ethanol in blood content.
Fig. 3 is the gas chromatogram of the present invention's blank plasma when measuring ethanol in blood content.
Fig. 4 is the present invention's target gas chromatogram in butanone when measuring ethanol in blood content.
Fig. 5 is the gas chromatogram of the present invention's blood serum sample when measuring ethanol in blood content.
Fig. 6 is the gas chromatogram of the present invention's acetaldehyde standard items when measuring acetaldehyde in blood.
Fig. 7 is the gas chromatogram of the present invention's blank plasma when measuring acetaldehyde in blood.
Fig. 8 is the present invention's target gas chromatogram in butanone when measuring acetaldehyde in blood.
Fig. 9 is the gas chromatogram of the present invention's blood serum sample when measuring acetaldehyde in blood.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the invention will be further described.
Detailed description of the invention one: selected Ilex Latifolia Thunb 1.6 Kg, the root of kudzu vine 1.6 Kg, cape jasmine 3.2 Kg, cordate houttuynia 3.2 Kg, dandelion 3.2 Kg, the fruit of Chinese wolfberry 1.6 Kg, date 1.0 Kg, Radix Glycyrrhizae 0.5 Kg, cleans it, segment, drops into shell and tube circulating extraction, adds cold water 984.1 Kg while feeding intake, opening clamp layered heating, is rapidly heated 90 DEG C, keeps 30 minutes at this temperature, extract after essence filter, filling, sterilizing, cooling, packaging, product inspection, warehouse-in.
Detailed description of the invention two: selected Ilex Latifolia Thunb 1.6 Kg, the root of kudzu vine 1.6 Kg, cape jasmine 3.2 Kg, cordate houttuynia 3.2 Kg, dandelion 3.2 Kg, the fruit of Chinese wolfberry 1.6 Kg, date 1.0 Kg, Radix Glycyrrhizae 0.5 Kg, cleans it, segment, drop into shell and tube circulating extraction, add maltodextrin 2.5 Kg while feeding intake, honey 2.5 Kg, cold water 979.1 Kg, opening clamp layered heating, is rapidly heated 90 DEG C, keeps 30 minutes at this temperature, extract after essence filter, filling, sterilizing, cooling, packaging, product inspection, warehouse-in.
Detailed description of the invention three: selected Ilex Latifolia Thunb 1.6 Kg, the root of kudzu vine 1.6 Kg, cape jasmine 3.2 Kg, cordate houttuynia 3.2 Kg, dandelion 3.2 Kg, the fruit of Chinese wolfberry 1.6 Kg, date 1.0 Kg, Radix Glycyrrhizae 0.5 Kg, it is cleaned, segment, drop into shell and tube circulating extraction, cold water 984.1 Kg is added while feeding intake, opening clamp layered heating, be rapidly heated 90 DEG C, keep 30 minutes at this temperature, extract adds pectase after essence filter, amylase, carbohydrase, gelatin, shitosan, polyvinylpyrrolidone, diatomite, ZTC1+1 fining agent, filling, sterilizing, cooling, packaging, product inspection, warehouse-in.
Detailed description of the invention four: selected Ilex Latifolia Thunb 1.6 Kg, the root of kudzu vine 1.6 Kg, cape jasmine 3.2 Kg, cordate houttuynia 3.2 Kg, dandelion 3.2 Kg, the fruit of Chinese wolfberry 1.6 Kg, date 1.0 Kg, Radix Glycyrrhizae 0.5 Kg, it is cleaned, segment, drop into shell and tube circulating extraction, maltodextrin 2.5 Kg is added while feeding intake, honey 2.5 Kg, cold water 979.1 Kg, opening clamp layered heating, be rapidly heated 90 DEG C, keep 30 minutes at this temperature, extract adds pectase after essence filter, amylase, carbohydrase, gelatin, shitosan, polyvinylpyrrolidone, diatomite, filling, sterilizing, cooling, packaging, product inspection, warehouse-in.
Detailed description of the invention five: animal divides into groups: mouse is divided into 3 groups at random, blank group, other antialcoholic drug group, YIGANCAO plant beverage group of the present invention, often organizes 10.Gastric infusion: each group is by body weight gastric infusion, blank group gavage distilled water, other antialcoholic drug group group gavage " clear-headed chewable tablets ", YIGANCAO plant beverage group gavage of the present invention YIGANCAO plant beverage of the present invention, 0.15ml/10g gavage Red Star strong, colourless liquor distilled from sorghum is pressed in administration after 30 minutes, give and within 1.5 hours after drinking, carry out mouse and pluck eyeball and get blood, hatch 30 minutes for 37 DEG C, the centrifugal 10min of 3000r, separation of serum ,-20 DEG C of Refrigerator stores are stand-by.
Alcohol determining condition, chromatographic column: Cp-Wax52CB; Injector temperature: 80 DEG C; Incubation temperature: 80 DEG C; Flow rate of carrier gas: 100.0ul/Sec; Incubation time: 15 min; Temperature programming: initial temperature 30 DEG C, stops 4min; 20 DEG C/min rises to 40 DEG C, stops 1min; After rise to 150 DEG C with 30 DEG C/min, stop 1min; Total time 14.67min.
Iso-propyl alcohol condition, chromatographic column: Cpsil5CB-2; Injector temperature: 80 DEG C; Incubation temperature: 80 DEG C; Flow rate of carrier gas: 100.0ul/Sec; Incubation time: 15 min; Temperature programming: initial temperature 30 DEG C, stops 4min; 20 DEG C/min rises to 40 DEG C, stops 1min; After rise to 150 DEG C with 30 DEG C/min, stop 1min; Total time 14.67min.
The mensuration of ethanol content in serum, the preparation of calibration curve: accurately measuring concentration is that each 1ml of ethanol titer of 0.8mg/ml, 0.4mg/ml, 0.2mg/ml, 0.1mg/ml, 0.5mg/ml, 0.01mg/ml, 0.005mg/ml adds in ml headspace bottle, then 0.1ml blank serum is measured in ml headspace bottle with liquid-transfering gun respectively, cover bottle cap, pressure bottle opener compresses.Carry out headspace gas chromatography detection according to chromatographic condition, the ratio of record gained ethanol and the peak area of butanone, linear regression obtains calibration curve.The rate of recovery: accurately measure in 5ml ethanol storing solution, 1.5ml butanone storing solution A to 10ml volumetric flask, be titrated to scale, obtain that concentration of alcohol is 0.5mg/ml, butanone concentration is the solution C of 1.5ug, measure in 1ml solution C to ml headspace bottle and add 0.1ml blank serum, cover compression bottle cap, measure concentration of alcohol.Repeat to make six samples.Reappearance and precision: the same sample of replication six times.Minimum detectability: according to standard curve determination result, the ethanol titer of measured amounts, adds blank serum, constantly reduces ethanol standard liquid measure, until signal to noise ratio is 3:1.Sample size measures: pipette blood serum sample 0.1 ml and butanone standard liquid (C reagent) 1 ml in ml headspace bottle, headspace gas chromatography detection is carried out according to chromatographic condition, record gained blood serum sample ethanol and the ratio of the peak area of butanone, according to calibration curve, calculate the concentration of ethanol in serum.
The mensuration of acetaldehyde in serum.The preparation of calibration curve: accurately measuring concentration is that the acetaldehyde titer 1ml of 10ug/ml, 5ug/ml, 4ug/ml, 2ug/ml, 1ug/ml, 0.5ug/ml adds in ml headspace bottle, then 0.1ml blank serum is measured in ml headspace bottle with liquid-transfering gun respectively, cover bottle cap, pressure bottle opener compresses.Carry out headspace gas chromatography detection according to chromatographic condition, the ratio of record gained ethanol and the peak area of butanone, linear regression obtains calibration curve.The rate of recovery: measure concentration be the ethanol 1ml of 10ug/ml in ml headspace bottle, add 0.1ml blank serum, cover compression bottle cap, measure concentration of alcohol.Repeat to make six samples.Reappearance and precision: the same sample of replication six times.Minimum detectability: according to standard curve determination result, the acetaldehyde titer of measured amounts, adds blank serum, constantly reduces ethanol standard liquid measure, until signal to noise ratio is 3:1.Sample size measures: pipette blood serum sample 0.1 ml and butanone standard liquid (C reagent) 1 ml in ml headspace bottle, headspace gas chromatography detection is carried out according to chromatographic condition, record gained whole blood sample acetaldehyde and the ratio of the peak area of butanone, according to calibration curve, calculate the concentration of acetaldehyde in serum.
Test result is as follows:
| Ethanol (mg/mL) | Acetaldehyde (ug/mL) | |
| Blank group | 2.14±0.8 | 32.34±14.15 |
| Other antialcoholic drug group (clear-headed chewable tablets) | 0.98±0.64 | 43.24±17.68 |
| YIGANCAO plant beverage group of the present invention | 0.09±0.12 | 9.30±9.86 |
Detailed description of the invention six: the active testing of alcohol dehydrogenase, catalase, superoxide dismutase: mouse is divided into 3 groups at random: blank group, other antialcoholic drug group, YIGANCAO plant beverage group of the present invention, often organizes 10.Gastric infusion: each group is by body weight gastric infusion, blank group gavage distilled water, other antialcoholic drug group group gavage " clear-headed chewable tablets ", YIGANCAO plant beverage group gavage of the present invention YIGANCAO plant beverage of the present invention, 0.15ml/10g gavage Red Star strong, colourless liquor distilled from sorghum is pressed in administration after 30 minutes, within 1.5 hours after drinking, drawn cervical vertebra to put to death.Take liver and add physiological saline and make 10% homogenate.The activity of the alcohol dehydrogenase in RNA isolation kit mensuration mouse liver tissue, catalase, superoxide dismutase.
Test result is as follows:
| Alcohol dehydrogenase (U/mgprot) | Catalase (U/mgprot) | Superoxide dismutase (U/mgprot) | |
| Blank group | 66.65±45.83 | 65.26±19. 27 | 94.39±42.77 |
| Other antialcoholic drug group (clear-headed chewable tablets) | 70.73±33.42 | 36.05±15.17 | 142.05±67. 40 |
| YIGANCAO plant beverage group of the present invention | 101.25±31.98 | 70.57±18.76 | 213.03±36.65 |
Claims (10)
1. a YIGANCAO plant beverage, is characterized in that, its active component is made up of the component of following weight proportioning:
Ilex Latifolia Thunb 0.15 ~ 0.2%, the root of kudzu vine 0.1 ~ 0.2%, cape jasmine 0.2 ~ 0.4%, cordate houttuynia 0.2 ~ 0.4%, dandelion 0.2 ~ 0.4%, the fruit of Chinese wolfberry 0.1 ~ 0.2%, date 0.05 ~ 0.2%, Radix Glycyrrhizae 0.01 ~ 0.1%, maltodextrin 0 ~ 0.4%, honey 0 ~ 0.4%, all the other are water.
2. YIGANCAO plant beverage according to claim 1, is characterized in that, Ilex Latifolia Thunb 0.16 ~ 0.17%, the root of kudzu vine 0.15 ~ 0.17%, cape jasmine 0.3 ~ 0.35%, cordate houttuynia 0.3 ~ 0.35%, dandelion 0.3 ~ 0.35%, the fruit of Chinese wolfberry 0.15 ~ 0.17%, date 0.08 ~ 0.12%, Radix Glycyrrhizae 0.04 ~ 0.06%, maltodextrin 0 ~ 0.3%, honey 0 ~ 0.3%, all the other are water.
3. YIGANCAO plant beverage according to claim 1, is characterized in that, described cape jasmine, is little Yellow Fructus Gardeniae, through frying, uses after removing bitter taste, and described Ilex Latifolia Thunb is fully dry dry tea.
4. prepare the equipment of YIGANCAO plant beverage described in claim 1, it is characterized in that, described equipment comprises tubulation circulating extraction, and the multiple pipeline for extract flowing of parallel placement in extractor, the outer sandwich establishment heater of pipeline is heating liquid in pipeline.
5. prepare the method for YIGANCAO plant beverage described in claim 1, it is characterized in that, take Ilex Latifolia Thunb in ratio described in claim 1, the root of kudzu vine, cape jasmine, cordate houttuynia, dandelion, the fruit of Chinese wolfberry, date, Radix Glycyrrhizae, it is cleaned, segment, drop into shell and tube circulating extraction, add cold water while feeding intake, opening clamp layered heating, be warmed up to 90 DEG C, keep 30 minutes at this temperature, extract after essence filter, filling, sterilizing, cooling, packaging, product inspection, warehouse-in.
6. method according to claim 5, is characterized in that, adds enzyme fining agent, gelatin, shitosan, polyvinylpyrrolidone, diatomite, one or more in ZTC1+1 fining agent, eliminate the muddy thing in YIGANCAO plant beverage after the filter of extract essence.
7. method according to claim 6, described enzyme fining agent is the combination of pectase, amylase and carbohydrase.
8. the application of YIGANCAO plant beverage described in claim 1, before drinking or in drinking or after drinking, take YIGANCAO plant beverage described in claim 1, obviously can alleviate dry common after drinking, feel sick, headache, tired, palpitating speed, apocleisis, dizzy symptom, significantly shorten the drunk time.
9. YIGANCAO plant beverage described in claim 1 relieves the effect of alcohol the assessment method of effect: mouse is divided into 3 groups at random, be respectively blank group, other antialcoholic drug group, YIGANCAO plant beverage group described in claim 1, by Mouse Weight to antialcoholic drug, blank group feedwater, 0.15ml/10g gavage Red Star strong, colourless liquor distilled from sorghum is pressed after 30 minutes, give 1.5 hours after drinking, eyeball is plucked to mouse and gets blood, then utilize gas-chromatography to test the ethanol content in mice serum and acetaldehyde, list contrasts effect of relieving the effect of alcohol.
10. the assessment method of YIGANCAO plant beverage liver protective effect described in claim 1: mouse is divided into 3 groups at random, be respectively blank group, other antialcoholic drug group, YIGANCAO plant beverage group described in claim 1, by Mouse Weight to antialcoholic drug, blank group feedwater, 0.15ml/10g gavage Red Star strong, colourless liquor distilled from sorghum is pressed after 30 minutes, give 1.5 hours after drinking, cervical vertebra is drawn to put to death, take liver and add physiological saline and make 10% homogenate, adopt the alcohol dehydrogenase in RNA isolation kit mensuration mouse liver tissue, catalase, the activity of superoxide dismutase, list contrasts effect of relieving the effect of alcohol.
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| CN105901222A (en) * | 2016-04-25 | 2016-08-31 | 陈志华 | Formula of alcohol effect-alleviating toxin-expelling herbal tea |
| CN107087734A (en) * | 2017-03-16 | 2017-08-25 | 广西玉林制药集团有限责任公司 | A kind of health composition of appetite-stimulating indigestion-relieving, beverage and preparation method thereof |
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Denomination of invention: Liver tonifying herbaceous plant beverage Effective date of registration: 20191010 Granted publication date: 20161102 Pledgee: Guiding rural credit cooperative association|Guizhou Duyun Rural Commercial Bank Co., Ltd.|Guizhou Dushan Rural Commercial Bank Co., Ltd.|Guizhou Pingtang Rural Commercial Bank Co., Ltd.|Guizhou Sandu Rural Commercial Bank Co., Ltd.|Guizhou Longli Rural Commercial Bank Co., Ltd.|Guizhou Huishui Rural Commercial Bank Co., Ltd.|Changshun rural credit Cooperative association|Luodian Rural Credit Cooperative Association Pledgor: GUIZHOU MIAOGULIANG FOOD CO., LTD. Registration number: Y2019990000312 |