CN1049139C

CN1049139C - Application 'Xintie'an' of curing heart disease and preparing process thereof

Info

Publication number: CN1049139C
Application number: CN94119838A
Authority: CN
Inventors: 周喜金
Original assignee: Individual
Current assignee: Individual
Priority date: 1994-12-14
Filing date: 1994-12-14
Publication date: 2000-02-09
Anticipated expiration: 2014-12-14
Also published as: CN1106694A

Abstract

The present invention relates to an externally-applied traditional Chinese medicine preparation for treating heart disease, which is mainly prepared from traditional Chinese medicine comprising red sage root, safflower and bezoar and other traditional Chinese medicine with the functions for relieving chest stuffiness, regulating qi, activating blood circulation, removing stasis, clearing away heat and promoting urination. By the unique principle of treating internal diseases by means of external treatment, the preparation performs therapeutic effects on the heart directly through percutaneous absorption. The preparation has the advantages of concentrated medicine efficacy, strong permeability, easy absorption, rapidness for taking effect, obvious curative effect, simple and convenient application, safety, reliability and no toxic or side effect.

Description

Cardiopathic application compress of a kind of treatment and preparation technology thereof

The present invention relates to a kind of external application drug of topical application thing, particularly be applicable to the preparation that the cardiopathic pure Chinese medicine of treatment sticks outward.

The medicine application therapy is a kind of novel form that develops over year surplus in the of nearly ten, by percutaneous drug delivery, except rising the local action, can also see through skin and enter blood circulation, the performance general action; And be not subjected to the influence of gastrointestinal tract chemical factors, thus improve bioavailability of medicament, alleviated side effects of pharmaceutical drugs.

Chinese traditional treatment angina pectoris application therapy has been seen at present the many cases report, as the peaceful cream treatment of Chinese medicine angina pectoris coronary heart disease angor 100 routine observation of curative effect/Liu Yingnian // Liaoning Journal of Traditional Chinese Medicine 1984.8 (12) P23; Moschus angina pectoris external application for curing angina pectoris 287 examples are observed/peaceful choosing ... // combination of Chinese and Western medicine magazine 1998.8 (7) P409.Be the Chinese medicine of blood circulation promoting and blood stasis dispelling, causing resuscitation with aromatic drugs from the prescription of above medicine, be and control " mark " and establish, use is suited the medicine to the illness in the pain phase, but how set upright in the angina phase and to control " basis ", yet there are no relevant report, and application method is also only at angina pectoris with application method, during treating, changed medicine once in general 24 hours, also trouble, such as rheumatic heart disease, heart disease such as tachycardia there is no the useful bibliographical information that sticks medicine on the paroxysmal chamber to other type.

The objective of the invention is to only can take stopgap measures and to effect a permanent cure in order to overcome above treatment angina pectoris, and therapeutic domain is narrow partially, stick deficiency often, on the basis of secret prescription handed down in the family from generation to generation, study through clinical practice for many years, scientifically plus-minus is write out a prescription, not only adopted traditional blood circulation promoting and blood stasis dispelling, the Chinese medicine of causing resuscitation with aromatic drugs, also be aided with invigorating the spleen and replenishing QI, heat clearing away is alleviated pain, inducing diuresis to remove edema, the chest stuffiness relieving reduces phlegm, the medicine of relieving cough and asthma, make prescription more be tending towards reasonability, scientific, the patch of making more helps the efficacy of a drug and arrives focus by meridians Yu cave and local dermal osmosis, bring into play its chest stuffiness relieving and regulate the flow of vital energy blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, heat-clearing and toxic substances removing, adjust the effect of cardiac function.

The objective of the invention is to adopt following prescription to reach (by weight):

10 parts in natural Calculus Bovis 1.5-2 part Semen Persicae

Stigma Croci 3-5 part Sanguis Draxonis 6-8 part

Radix Salviae Miltiorrhizae 10-12 part Semen Armeniacae Amarum 8-10 part

Semen Momordicae 3-5 part Borneolum Syntheticum 0.5-0.7 part

Bright Misgurni anguillicaudati 30-50 part Fel Sus domestica 0.5-1.5 part

The preparation technology who produces medicine of the present invention is:

A, weighing and burden:

The prescription of example below the raw material is taken by weighing by weight:

10 parts in natural Calculus Bovis 1.5-2 part Semen Persicae

Stigma Croci 3-5 part Sanguis Draxonis 6-8 part

Radix Salviae Miltiorrhizae 10-12 part Semen Armeniacae Amarum 8-10 part

Semen Momordicae 3-5 part Borneolum Syntheticum 0.5-0.7 part

Bright Misgurni anguillicaudati 30-50 part Fel Sus domestica 0.5-1.5 part

B, except that bright Misgurni anguillicaudati and Fel Sus domestica with other eight flavors medicine altogether the porphyrize powder cross 100 mesh sieves, then the Buddhist nun loach is mashed, add the medicated powder after sieving, Fel Sus domestica is transferred and is mixed evenly, makes pancake.

Now the present invention is further described in conjunction with the embodiments:

Embodiment 1:

Natural Calculus Bovis 1.5g Semen Persicae 10g Stigma Croci 3g Sanguis Draxonis 6g

Radix Salviae Miltiorrhizae 10g Semen Armeniacae Amarum 8g Semen Momordicae 3g Borneolum Syntheticum 0.5g

Remove bright Misgurni anguillicaudati, outside the Fel Sus domestica, above eight flavor medicine weighings are total to levigation cross 100 mesh sieves, then bright Misgurni anguillicaudati 30g mashed, Fel Sus domestica 0.5g is even with medicated powder mixing puddle, makes pancake.

Embodiment 2:

Natural Calculus Bovis 2g Semen Persicae 10g Stigma Croci 5g

Sanguis Draxonis 8g Radix Salviae Miltiorrhizae 12g Semen Armeniacae Amarum 10g

The bright Misgurni anguillicaudati 50g of Semen Momordicae 5g Borneolum Syntheticum 0.7g

Fel Sus domestica 1.5g

Embodiment 3:

Natural Calculus Bovis 1.5g Semen Persicae 10g Stigma Croci 4g

Sanguis Draxonis 7g Radix Salviae Miltiorrhizae 10g Semen Armeniacae Amarum 9g

The bright Misgurni anguillicaudati 40g of Semen Momordicae 4g Borneolum Syntheticum 0.6g

Fel Sus domestica 1g

Above embodiment technology is with embodiment 1.

This heart disease application compress system inventor secret recipe handed down in the family; through clinical practice decades; by the external therapy of uniqueness, make the direct transdermal flux absorption of medicine and bring into play its therapeutical effect, and can make meridians unobstructed by the through cardia in meridians Yu cave; QI and blood is in harmonious proportion; promote the adjusting activity of internal organs meridians, improve cardiac function, and reach therapeutic purposes; this method special effect; have the efficacy of a drug and concentrate, permeability is strong, absorbs easily; long action time; inner disease outer treat produces effects rapidly, uses bright Misgurni anguillicaudati to have invigorating the spleen and replenishing QI in the side; penetrance is strong; inducing diuresis to remove edema, and natural Calculus Bovis and Fel Sus domestica also alleviate pain with having heat clearing away; the chest stuffiness relieving reduces phlegm, the synergism of relieving cough and asthma; Myrrha is safe and reliable, has no side effect; determined curative effect.

Using method is medicine cake external calico one deck, immobilization with adhesive tape.The drug of topical application can be removed in 24 hours in the cave in the external application void, every the drug of topical application on the 20th once, was a course of treatment, and can produce appreciable results a course of treatment.Curing generally needs 3-4 the course of treatment, and rheumatic heart disease needs 4-6 the course of treatment.

Below be 460 routine disease treatment situation abridged tables

The sick kind	The example number		Add up to
	The example number			The man	The woman
	The wind heart	98		The man	The woman	118	216
The coronary disease angina pectoris	The wind heart	98	69	111	182	118	216
The coronary disease angina pectoris	Supraventricular tachycardia	28	69	111	182	34	62

Therapeutic outcome: 1, rheumatic heart disease 216 examples, total effective rate 91.67%.

Before the treatment	After the treatment
	After the treatment				Level Four	Three grades	Secondary	Once
	Cardiac function	4 three grade of 105 secondary 107 of level Four	0 0 0	2 10 0	Level Four	Three grades	Secondary	Once	2 60 8	0 35 99

2, angina pectoris 182 examples, total effective rate 92.31%.

Before the treatment	After the treatment
	After the treatment	Produce effects is improved invalid substantially increasing the weight of
	The angor degree		86 heavier 2 is heavy by 2 in light 92	84 4 4 0 58 20 8 0 0 1 1 0 0 1 1 0

3, old property supraventricular tachycardia 62 examples, total effective rate 95.16%.

		Once	Once	Once	Once
		Once	Once	Once	Once	Week	2 weeks	Month	The 1-3 month
		Before the treatment		6	35	Week	2 weeks	Month	The 1-3 month	16	5
After the treatment	Control fully	Before the treatment		6	35	3	18	5	3	16	5
	Control fully	Basic controlling	2	16	10	3	18	5	3	2
	Invalid	Basic controlling	2	16	10	1	1	1	0	2

The acute toxicity test of this medicine is reported as follows:

Experiment material:

Animal: Kunming kind white mice is provided by Jiangxi Medical College's Experimental Animal Center.

Reagent: heart disease application compress and stick material and provide by the Zhou Xijin doctor of medical clinic portion of the Nanchang City association for science and technology.

Method and result:

1, anterior pectorial region external application maximum tolerance determination: Kunming kind white mice, male and female half and half, body weight 19-22g, divide equally 2 groups, every group 20, the experiment before with little shears carefully cut off the mice anterior pectorial region mao, note not damaged mouse skin, mice is fixed on the frog board, makes negative control with sticking material for one group.Another group reagent, in sticking material, add the dressing that the heart disease application compress are made into 751100 (W/W), 150g/Kg spreads on the front, and external gauze and immobilization with adhesive tape are removed medicine after in the time of 24 hours, mice group is put back in the mouse cage and is raised, observed 7 days, not seeing has any Deviant Behavior and death, because of mice anterior pectorial region area limited, can't the more reagent of high dose of external application, an anterior pectorial region external application heart disease application compress maximum tolerated dose＞112.5g/kg.

2, anterior pectorial region subcutaneous injection heart disease application compress LD ₅₀Measure: 60 of (1) Kunming mouses, be divided into 6 groups at random, 10 every group, male female half and half.The 1-5 group is the administration group, and the subcutaneous injection common ratio is 5 dosage of 0.8 successively, and the 6th group is matched group, and the isometric physiologic dose brine of IP was raised 7 days, observed the outward appearance behavior and the death toll of each treated animal, and some animal activity of reagent group as a result reduces death toll and sees Table 1:

Table 1:

Dosage (g/kg)	Number of animals (only)	Death toll	Mortality rate (%)
Dosage (g/kg)	Number of animals (only)	Death toll	Mortality rate (%)	The normal saline isometric(al)	10	0	0
Heart disease application compress 20	10	9	90	The normal saline isometric(al)	10	0	0
Heart disease application compress 20	10	9	90	Heart disease application compress 16	10	9	90
Heart disease application compress 12.8	10	6	60	Heart disease application compress 16	10	9	90
Heart disease application compress 12.8	10	6	60	Heart disease application compress 10.24	10	3	30
Heart disease application compress 8.19	10	0	0	Heart disease application compress 10.24	10	3	30

Calculate 1 this medicine of anterior pectorial region subcutaneous injection of white mice with Guan Shi method (2), observe 7 days LD ₅₀And 95% fiducial limit is respectively 12.24g/kg and 13.66-11.26g/kg.

Brief summary:

The white mice anterior pectorial region once sticked this medicine 24 hours, observed maximum tolerated dose＞112.5g/kg of 7 days, and greater than clinical 281.25 times of once sticking this medication amount 0.4/kg, viewing duration is not seen toxic reaction.This medicine of white mice subcutaneous injection is observed 7 days LD ₅₀Reaching 95% credible 12.24g/kg of being limited to and 13.66-11.26g/kg is 30.6 times that a clinical anterior pectorial region sticks this drug dose 0.49g/kg.

According to China's " provisions for new drugs approval " regulation, acute toxicity test, Chinese medicine surpasses and is equivalent to the clinical consumption of people more than 100 times, injecting pathway surpasses 2g/kg, do not produce death and/or toxic reaction yet, or when thing death or toxic reaction only occurring not moving, needn't improve again with dosage and continue experiment.This medicine subcutaneous injection 8.19g/kg does not see mice dying, and the anterior pectorial region once sticks the maximum tolerated dose of this medicine greater than 281 times of clinical consumptions.Therefore, we think that it is safe that this medicine applies pareordia treatment disease.

Above laboratory report is provided by pharmacological room of Jiangxi Medical College, and the time is one nine nine four on JIUYUE 23.

Claims

1, the cardiopathic liniment of a kind of treatment is characterized in that it is to be made by the following weight proportion raw material:

10 parts in natural Calculus Bovis 1.5-2 part Semen Persicae

Stigma Croci 3-5 part Sanguis Draxonis 6-8 part

Radix Salviae Miltiorrhizae 10-12 part Semen Armeniacae Amarum 8-10 part

Semen Momordicae 3-5 part Borneolum Syntheticum 0.5-0.7 part

Bright Misgurni anguillicaudati 30-50 part Fel Sus domestica 0.5-1.5 part

2, a kind of preparation technology who treats cardiopathic liniment is characterized in that preparing in accordance with the following methods:

A, weighing and burden

Raw material is taken by weighing by weight with following prescription:

10 parts in natural Calculus Bovis 1.5-2 part Semen Persicae

Stigma Croci 3-5 part Sanguis Draxonis 6-8 part

Radix Salviae Miltiorrhizae 10-12 part Semen Armeniacae Amarum 8-10 part

Semen Momordicae 3-5 part Borneolum Syntheticum 0.5-0.7 part

Bright Misgurni anguillicaudati 30-50 part Fel Sus domestica 0.5-1.5 part

B, except that bright Misgurni anguillicaudati and Fel Sus domestica, other eight flavors medicine is altogether crossed 100 mesh sieves behind the levigation, in addition bright Misgurni anguillicaudati is mashed, with sieve after medicated powder, Fel Sus domestica is mixed thoroughly, makes pancake.