CN104906309A - Eye dressing for treating bovine keratoconjunctivitis and preparation method and application thereof - Google Patents
Eye dressing for treating bovine keratoconjunctivitis and preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the field of animalsin aquaculture medicine, particularly belongs to the field of medicine for treating bovine keratoconjunctivitis, and provides an eye dressing for treating bovine keratoconjunctivitis and a preparation method and application thereof. The eye dressing can effectively treat the bovine keratoconjunctivitis of cows, is free of biosafety risks and convenient to use, and has very important significance for developing cow rearing industry and improving economic benefits. The preparation method of the traditional Chinese medicine eye dressing for treating bovine keratoconjunctivitis is characterized by being obtained by crushing, extracting and mixing Chinese yam, Chinese ephedra, liquorice and medicinal cyathula roots. The eye dressing is used for treating bovine keratoconjunctivitis.
Description
Technical field
The invention belongs to cultivated animals drug world used, in particular for the drug world for the treatment of cattle keratoconjunctivitis.
Background technology
Cattle keratoconjunctivitis is caused by outer infections mostly, happens occasionally in cattle cultivation.The cattle of morbidity, often shed tears, photophobia, corneal clouding, canescence nebula hoodwink, invest eyes-affinity with glutinous sample purulent secretion, the symptoms such as eyelid swelled conjunctival congestion sometimes.After the cattle given milk suffers from keratoconjunctivitis, spirit is uneasy, and milk yield declines, and as properly treated not in time, even there will be simple eye or blindness, causing economic loss.The Therapeutic Method that cattle keratoconjunctivitis is traditional is adopt antibiotic, hormone therapy mostly, and the food residual contamination of antibiotic, hormone medicine, and antibiotic drug resistance, the impact of hormone on Lactation of Dairy Cow makes its application in animal husbandry have larger limitation.The present invention is that one can effectively treat milch cow keratoconjunctivitis, inanimate object potential safety hazard again, Chinese medicine easy to use, for development cattle aquaculture, improves economic well-being of workers and staff tool and is of great significance.
Summary of the invention
The technical solution adopted for the present invention to solve the technical problems is such:
1, the manufacture method of the middle drug application eye agent for the treatment of cattle keratoconjunctivitis, is characterized in that: the agent of described middle drug application eye is obtained by following steps:
The first step, Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae wash clean, drying, pulverizes respectively, obtained Rhizoma Dioscoreae powder, Herba Ephedrae powder, Radix Glycyrrhizae powder, Radix Cyathulae powder, for subsequent use,
And: parts by weight are: Rhizoma Dioscoreae powder 100-300 part, Herba Ephedrae powder 200-400 part, Radix Glycyrrhizae powder 400-800 part, Radix Cyathulae powder 400-800 part,
And: the degree of grinding of Rhizoma Dioscoreae is 200 orders, and the degree of grinding of Radix Cyathulae is 200 orders,
Second step, gets the Herba Ephedrae powder described in the first step, and add the ethanol water of Herba Ephedrae opaque amount 5 times amount, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction twice, extraction time 50min,
Decompress filter, collects filtrate,
Filtrate reduced in volume is volatilized solvent,
Extract obtainedly pulverize, 4 DEG C of cold preservations are for subsequent use;
3rd step, gets the Radix Glycyrrhizae powder described in the first step, adds the ethanol water of Radix Glycyrrhizae powder quality 8 times amount, and described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
70 DEG C of circumfluence distillation 60min,
Collecting by filtration extracting solution, and obtain medicinal residues,
In gained medicinal residues, add the ethanol water of medicinal residues quality 2 times amount again, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction 30min,
Collecting by filtration extracting solution, merging filtrate,
Put water-bath evaporation to volatilize,
Pulverized by extract, 4 DEG C of cold preservations are for subsequent use;
4th step, gets the Rhizoma Dioscoreae powder described in the first step, Radix Cyathulae powder mix homogeneously, adds step 2 in the lump, step 3 is extract obtained, and add described mixture gross mass 0.8-0.9 water doubly, mixing grinds well, and becomes pastel.
Further: the weight portion of Rhizoma Dioscoreae powder is 200, the weight portion of Radix Cyathulae powder is 400, and the weight portion of Radix Glycyrrhizae powder is 800, and the weight portion of Herba Ephedrae is 200.
2, be used for the treatment of the middle drug application eye agent of cattle keratoconjunctivitis, it is characterized in that: the agent of described middle drug application eye be by:
Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae obtain.
3, be used for the treatment of the middle drug application eye agent of cattle keratoconjunctivitis, it is characterized in that:
The agent of described middle drug application eye is obtained by following methods:
The first step, Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae wash clean, drying, pulverizes respectively, obtained Rhizoma Dioscoreae powder, Herba Ephedrae powder, Radix Glycyrrhizae powder, Radix Cyathulae powder, for subsequent use,
And: parts by weight are: Rhizoma Dioscoreae powder 100-300 part, Herba Ephedrae powder 200-400 part, Radix Glycyrrhizae powder 400-800 part, Radix Cyathulae powder 400-800 part, and: the degree of grinding of Rhizoma Dioscoreae is 200 orders, and the degree of grinding of Radix Cyathulae is 200 orders,
Second step, gets the Herba Ephedrae powder described in the first step, and add the ethanol water of Herba Ephedrae opaque amount 5 times amount, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction twice, extraction time 50min,
Decompress filter, collects filtrate,
Filtrate reduced in volume is volatilized solvent,
Extract obtainedly pulverize, 4 DEG C of cold preservations are for subsequent use;
3rd step, gets the Radix Glycyrrhizae powder described in the first step, adds the ethanol water of Radix Glycyrrhizae powder quality 8 times amount, and described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
70 DEG C of circumfluence distillation 60min,
Collecting by filtration extracting solution, and obtain medicinal residues,
In gained medicinal residues, add the ethanol water of medicinal residues quality 2 times amount again, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction 30min,
Collecting by filtration extracting solution, merging filtrate,
Put water-bath evaporation to volatilize,
Pulverized by extract, 4 DEG C of cold preservations are for subsequent use;
4th step, gets the Rhizoma Dioscoreae powder described in the first step, Radix Cyathulae powder mix homogeneously, adds step 2 in the lump, step 3 is extract obtained, and add described mixture gross mass 0.8-0.9 water doubly, mixing grinds well, and becomes pastel.
Further: the weight portion of Rhizoma Dioscoreae powder is 200, the weight portion of Radix Cyathulae powder is 400, and the weight portion of Radix Glycyrrhizae powder is 800, and the weight portion of Herba Ephedrae is 200.
4, a kind of method for the treatment of cattle keratoconjunctivitis, is characterized in that: first use the ill milch cow eye of normal saline flushing, and then get medicament for the eyes 5g and be applied to trouble eye conjunctiva, cornea, every day 3 times, be used in conjunction 7 days, described medicament for the eyes is obtained by following steps:
The first step, Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae wash clean, drying, pulverizes respectively, obtained Rhizoma Dioscoreae powder, Herba Ephedrae powder, Radix Glycyrrhizae powder, Radix Cyathulae powder, for subsequent use,
And: parts by weight are: Rhizoma Dioscoreae powder 100-300 part, Herba Ephedrae powder 200-400 part, Radix Glycyrrhizae powder 400-800 part, Radix Cyathulae powder 400-800 part, and: the degree of grinding of Rhizoma Dioscoreae is 200 orders, and the degree of grinding of Radix Cyathulae is 200 orders,
Second step, gets the Herba Ephedrae powder described in the first step, and add the ethanol water of Herba Ephedrae opaque amount 5 times amount, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction twice, extraction time 50min,
Decompress filter, collects filtrate,
Filtrate reduced in volume is volatilized solvent,
Extract obtainedly pulverize, 4 DEG C of cold preservations are for subsequent use;
3rd step, gets the Radix Glycyrrhizae powder described in the first step, adds the ethanol water of Radix Glycyrrhizae powder quality 8 times amount, and described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
70 DEG C of circumfluence distillation 60min,
Collecting by filtration extracting solution, and obtain medicinal residues,
In gained medicinal residues, add the ethanol water of medicinal residues quality 2 times amount again, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction 30min,
Collecting by filtration extracting solution, merging filtrate,
Put water-bath evaporation to volatilize,
Pulverized by extract, 4 DEG C of cold preservations are for subsequent use;
4th step, gets the Rhizoma Dioscoreae powder described in the first step, Radix Cyathulae powder mix homogeneously, adds step 2 in the lump, step 3 is extract obtained, and add described mixture gross mass 0.8-0.9 water doubly, mixing grinds well, and becomes pastel.
Further: the weight portion of Rhizoma Dioscoreae powder is 200, the weight portion of Radix Cyathulae powder is 400, and the weight portion of Radix Glycyrrhizae powder is 800, and the weight portion of Herba Ephedrae is 200.
5, a kind of purposes of the medicine be made up of Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae, is characterized in that:
Described medicine is obtained by following methods:
The first step, Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae wash clean, drying, pulverizes respectively, obtained Rhizoma Dioscoreae powder, Herba Ephedrae powder, Radix Glycyrrhizae powder, Radix Cyathulae powder, for subsequent use,
And: parts by weight are: Rhizoma Dioscoreae powder 100-300 part, Herba Ephedrae powder 200-400 part, Radix Glycyrrhizae powder 400-800 part, Radix Cyathulae powder 400-800 part, and: the degree of grinding of Rhizoma Dioscoreae is 200 orders, and the degree of grinding of Radix Cyathulae is 200 orders,
Second step, gets the Herba Ephedrae powder described in the first step, and add the ethanol water of Herba Ephedrae opaque amount 5 times amount, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction twice, extraction time 50min,
Decompress filter, collects filtrate,
Filtrate reduced in volume is volatilized solvent,
Extract obtainedly pulverize, 4 DEG C of cold preservations are for subsequent use;
3rd step, gets the Radix Glycyrrhizae powder described in the first step, adds the ethanol water of Radix Glycyrrhizae powder quality 8 times amount, and described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
70 DEG C of circumfluence distillation 60min,
Collecting by filtration extracting solution, and obtain medicinal residues,
In gained medicinal residues, add the ethanol water of medicinal residues quality 2 times amount again, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction 30min,
Collecting by filtration extracting solution, merging filtrate,
Put water-bath evaporation to volatilize,
Pulverized by extract, 4 DEG C of cold preservations are for subsequent use;
4th step, gets the Rhizoma Dioscoreae powder described in the first step, Radix Cyathulae powder mix homogeneously, adds step 2 in the lump, step 3 is extract obtained, and add described mixture gross mass 0.8-0.9 water doubly, mixing grinds well, and becomes pastel,
The purposes of described medicine is: treatment cattle keratoconjunctivitis.
Further: the weight portion of Rhizoma Dioscoreae powder is 200, the weight portion of Radix Cyathulae powder is 400, and the weight portion of Radix Glycyrrhizae powder is 800, and the weight portion of Herba Ephedrae is 200.
The present invention is that one can effectively treat milch cow keratoconjunctivitis, inanimate object potential safety hazard again, Chinese medicine easy to use, for development cattle aquaculture, improves economic well-being of workers and staff tool and is of great significance.
Detailed description of the invention
Definition: Rhizoma Dioscoreae (Rhizoma Dioscoreae, Anhui), Herba Ephedrae (Herba Ephedrae, Xinjiang), Radix Glycyrrhizae (Radix Glycyrrhizae, Gansu), Radix Cyathulae (Radix Cyathulae, Sichuan).Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae and corresponding latin name are the Chinese herbal medicine determined, medicinal part those skilled in the art know that.
The first step, Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae wash clean, drying, pulverizes respectively, obtained Rhizoma Dioscoreae powder, Herba Ephedrae powder, Radix Glycyrrhizae powder, Radix Cyathulae powder, for subsequent use,
And: parts by weight are: Rhizoma Dioscoreae powder 100-300 part, Herba Ephedrae powder 200-400 part, Radix Glycyrrhizae powder 400-800 part, Radix Cyathulae powder 400-800 part, and: the degree of grinding of Rhizoma Dioscoreae is 200 orders, and the degree of grinding of Radix Cyathulae is 200 orders,
Second step, gets the Herba Ephedrae powder described in the first step, and add the ethanol water of Herba Ephedrae opaque amount 5 times amount, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction twice, ultrasonic device of the present invention is: SK3200H high-frequency ultrasonic washer, Shanghai High Kudos Science Instrument Co., Ltd.; Operating frequency: 53KHz, power: 150W, extraction time 50min,
Decompress filter, collects filtrate,
Filtrate reduced in volume is volatilized solvent,
Extract obtainedly pulverize, 4 DEG C of cold preservations are for subsequent use;
3rd step, gets the Radix Glycyrrhizae powder described in the first step, adds the ethanol water of Radix Glycyrrhizae powder quality 8 times amount, and described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
70 DEG C of circumfluence distillation 60min,
Collecting by filtration extracting solution, and obtain medicinal residues,
In gained medicinal residues, add the ethanol water of medicinal residues quality 2 times amount again, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction 30min, supersonic frequency 53KHz, power 150W
Collecting by filtration extracting solution, merging filtrate,
Put water-bath evaporation to volatilize, when various equivalent modifications should know this mixture containing water and ethanol of water-bath evaporation, the temperature of mixture is change, but under normal pressure, temperature is at most 100 degrees Celsius.
Pulverized by extract, 4 DEG C of cold preservations are for subsequent use;
4th step, get the Rhizoma Dioscoreae powder described in the first step, Radix Cyathulae powder mix homogeneously, add step 2 in the lump, step 3(step 2 is exactly second step, step 3 is exactly the 3rd step) extract obtained, add described mixture gross mass 0.8-0.9 water doubly, mixing grinds well, and becomes pastel.
Be exactly medicament for the eyes of the present invention by the pastel of the 4th step gained, or be called to be exactly Chinese medicine of the present invention, or be called deposited eye agent, or be called the agent of middle drug application eye.
Therapeutic Method:
First use the ill milch cow eye of normal saline flushing, get joined medicament for the eyes 5g and be applied to trouble eye conjunctiva, cornea, every day 3 times, be used in conjunction 7 days.
The invention solves medicine uses hormone in a large number, antibiotic brings potential safety hazard and the limitation such as biological pollution, acquired crossing drug resistant of existing treatment milch cow keratoconjunctivitis.The middle drug application eye agent that the present invention treats milch cow keratoconjunctivitis is made up of Rhizoma Dioscoreae, Radix Cyathulae, Herba Ephedrae, Radix Glycyrrhizae.Medicine material of the present invention is easily purchased, and processing technique is simple; Treatment milch cow keratoconjunctivitis is effective, economical, and biological safety is high, and has evaded the impact of hormone on Lactation of Dairy Cow; Drug use is convenient, unrestricted.
Test about therapeutic effect:
Method: select farm, Xinjiang to suffer from the china holstein cows 270 of keratoconjunctivitis, adopt orthogonal experimental design method L
9(3
4), screening optimum formula, refers to table 1, table 2.Test group is divided into 9 groups by random packet principle, often organizes 30.Integrated survey, calculating total effective rate.Improvement refers to that milch cow cornea conjunctivitis symptoms is alleviated, and as glutinous sample purulent secretion reduces, conjunctival congestion is alleviated, and nebula disappears to some extent.
A(Rhizoma Dioscoreae described in table 1): 100,200,300 all refer to weight portion; B(Radix Cyathulae): 400,600,800 also refer to weight portion; To C(Radix Glycyrrhizae), D(Herba Ephedrae) understand also like this.
Table 1 is L
9(3
4) factor level table.
Table 2 is orthogonal test scheme and result.
Table 3 is variance analysis.
Table 1 L
9(3
4) factor level table
| Level | A (Rhizoma Dioscoreae) | B (Radix Cyathulae) | C (Radix Glycyrrhizae) | D (Herba Ephedrae) |
| 1 | 100 | 400 | 400 | 200 |
| 2 | 200 | 600 | 600 | 300 |
| 3 | 300 | 800 | 800 | 400 |
Table 2 orthogonal test scheme and result
Table 3 variance analysis
| Factor | Sum of square of deviations | F Ratio | P |
| A (Rhizoma Dioscoreae) | 690.447 | 30.759 | <0.05 |
| B (Radix Cyathulae) | 466.667 | 20.790 | <0.05 |
| C (Radix Glycyrrhizae) | 89.780 | 4.000 | |
| D (Herba Ephedrae) | 22.447 | 1.000 |
From result of the test and analytical table 2, table 3, the main factor of drug application eye agent effective percentage in the present invention that affects is Rhizoma Dioscoreae, is secondly Radix Cyathulae.With preferred optimum formula A2B1C3D1 repeated trials 3 times, the high and stable curative effect of total effective rate.Experimental result refers to table 4.
Table 4 is optimum formula demonstration test result preferably
When patent electric application client (i.e. CPC) submit applications file, the lines of form may disappear a part, but various equivalent modifications can find out row, column.
Claims (3)
1. be used for the treatment of the middle drug application eye agent of cattle keratoconjunctivitis, it is characterized in that: the agent of described middle drug application eye be by:
Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae obtain.
2. treat the manufacture method of the middle drug application eye agent of cattle keratoconjunctivitis, it is characterized in that: the agent of described middle drug application eye is obtained by following steps:
The first step, Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae wash clean, drying, pulverizes respectively, obtained Rhizoma Dioscoreae powder, Herba Ephedrae powder, Radix Glycyrrhizae powder, Radix Cyathulae powder, for subsequent use,
And: parts by weight are: Rhizoma Dioscoreae powder 100-300 part, Herba Ephedrae powder 200-400 part, Radix Glycyrrhizae powder 400-800 part, Radix Cyathulae powder 400-800 part,
And: the degree of grinding of Rhizoma Dioscoreae is 200 orders, and the degree of grinding of Radix Cyathulae is 200 orders,
Second step, gets the Herba Ephedrae powder described in the first step, and add the ethanol water of Herba Ephedrae opaque amount 5 times amount, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction twice, extraction time 50min,
Decompress filter, collects filtrate,
Filtrate reduced in volume is volatilized solvent,
Extract obtainedly pulverize, 4 DEG C of cold preservations are for subsequent use;
3rd step, gets the Radix Glycyrrhizae powder described in the first step, adds the ethanol water of Radix Glycyrrhizae powder quality 8 times amount, and described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
70 DEG C of circumfluence distillation 60min,
Collecting by filtration extracting solution, and obtain medicinal residues,
In gained medicinal residues, add the ethanol water of medicinal residues quality 2 times amount again, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction 30min,
Collecting by filtration extracting solution, merging filtrate,
Put water-bath evaporation to volatilize,
Pulverized by extract, 4 DEG C of cold preservations are for subsequent use;
4th step, gets the Rhizoma Dioscoreae powder described in the first step, Radix Cyathulae powder mix homogeneously, adds step 2 in the lump, step 3 is extract obtained, and add described mixture gross mass 0.8-0.9 water doubly, mixing grinds well, and becomes pastel,
Further: the weight portion of Rhizoma Dioscoreae powder is 200, the weight portion of Radix Cyathulae powder is 400, and the weight portion of Radix Glycyrrhizae powder is 800, and the weight portion of Herba Ephedrae is 200.
3. a purposes for the medicine be made up of Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae, is characterized in that:
Described medicine is obtained by following methods:
The first step, Rhizoma Dioscoreae, Herba Ephedrae, Radix Glycyrrhizae, Radix Cyathulae wash clean, drying, pulverizes respectively, obtained Rhizoma Dioscoreae powder, Herba Ephedrae powder, Radix Glycyrrhizae powder, Radix Cyathulae powder, for subsequent use,
And: parts by weight are: Rhizoma Dioscoreae powder 100-300 part, Herba Ephedrae powder 200-400 part, Radix Glycyrrhizae powder 400-800 part, Radix Cyathulae powder 400-800 part, and: the degree of grinding of Rhizoma Dioscoreae is 200 orders, and the degree of grinding of Radix Cyathulae is 200 orders,
Second step, gets the Herba Ephedrae powder described in the first step, and add the ethanol water of Herba Ephedrae opaque amount 5 times amount, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction twice, extraction time 50min,
Decompress filter, collects filtrate,
Filtrate reduced in volume is volatilized solvent,
Extract obtainedly pulverize, 4 DEG C of cold preservations are for subsequent use;
3rd step, gets the Radix Glycyrrhizae powder described in the first step, adds the ethanol water of Radix Glycyrrhizae powder quality 8 times amount, and described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
70 DEG C of circumfluence distillation 60min,
Collecting by filtration extracting solution, and obtain medicinal residues,
In gained medicinal residues, add the ethanol water of medicinal residues quality 2 times amount again, described ethanol water is: the parts by volume of water is 30, and the parts by volume of ethanol is 70,
Supersound extraction 30min,
Collecting by filtration extracting solution, merging filtrate,
Put water-bath evaporation to volatilize,
Pulverized by extract, 4 DEG C of cold preservations are for subsequent use;
4th step, gets the Rhizoma Dioscoreae powder described in the first step, Radix Cyathulae powder mix homogeneously, adds step 2 in the lump, step 3 is extract obtained, and add described mixture gross mass 0.8-0.9 water doubly, mixing grinds well, and becomes pastel,
Further: the weight portion of Rhizoma Dioscoreae powder is 200, the weight portion of Radix Cyathulae powder is 400, and the weight portion of Radix Glycyrrhizae powder is 800, and the weight portion of Herba Ephedrae is 200,
The purposes of described medicine is: treatment cattle keratoconjunctivitis.
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|---|---|---|---|
| CN201510308141.4A CN104906309A (en) | 2015-06-08 | 2015-06-08 | Eye dressing for treating bovine keratoconjunctivitis and preparation method and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309669A (en) * | 2010-07-08 | 2012-01-11 | 高健生 | Chinese medicinal preparation for treating allergic conjunctivitis |
| CN102423349A (en) * | 2011-11-01 | 2012-04-25 | 文登市口腔医院米山路口腔诊所 | Traditional Chinese medicine for curing acute pinkeye |
| CN103071089A (en) * | 2013-01-18 | 2013-05-01 | 管丽芳 | Traditional Chinese medicine powder for treating epidemic keratoconjunctivitis |
| CN103784810A (en) * | 2013-12-13 | 2014-05-14 | 青岛德瑞骏发生物科技有限公司 | Medicine composition for treating conjunctivitis of horses |
-
2015
- 2015-06-08 CN CN201510308141.4A patent/CN104906309A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309669A (en) * | 2010-07-08 | 2012-01-11 | 高健生 | Chinese medicinal preparation for treating allergic conjunctivitis |
| CN102423349A (en) * | 2011-11-01 | 2012-04-25 | 文登市口腔医院米山路口腔诊所 | Traditional Chinese medicine for curing acute pinkeye |
| CN103071089A (en) * | 2013-01-18 | 2013-05-01 | 管丽芳 | Traditional Chinese medicine powder for treating epidemic keratoconjunctivitis |
| CN103784810A (en) * | 2013-12-13 | 2014-05-14 | 青岛德瑞骏发生物科技有限公司 | Medicine composition for treating conjunctivitis of horses |
Non-Patent Citations (2)
| Title |
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| 朱晓琳: "基于频数分析的明代角膜炎用药规律研究", 《四川中医》 * |
| 黄煌 等: "《经方100首》", 28 February 2013, 江苏科学技术出版社 * |
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Application publication date: 20150916 |