CN104888045A - Traditional Chinese medicine oral-administration medicament for treating cholecystolithiasis and preparation method therefor - Google Patents
Traditional Chinese medicine oral-administration medicament for treating cholecystolithiasis and preparation method therefor Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine oral-administration medicament for treating cholecystolithiasis. The traditional Chinese medicine oral-administration medicament is prepared from the following main raw materials in parts by weight: 15-20 parts of codonopsis pilosula, 4-8 parts of maifanite, 18-25 parts of bupleurum root, 10-20 parts of radix clematidis, 20-30 parts of Chinese yams, 30-40 parts of lysimachia, 15-30 parts of stringy stonecrop, 10-16 parts of green tangerine peel, 6-14 parts of radish seed, 15-28 parts of endothelium corneum gigeriae galli, 10-20 parts of coix seed, 5-15 parts of anemarrhenae rhizome, 3-8 parts of citrus aurantium and 8-14 parts of gentian root. The traditional Chinese medicine oral-administration medicament has a remarkable effect on cholecystolithiasis, not only has the effects of soothing liver and benefiting gallbladder and dissolving and removing calculus, but also can be used for strengthening stomach and normalizing the middle-warmer, inducing diuresis for treating stranguria and improving the suffering, resulting from long-term cholecystolithiasis, for patients; according to the traditional Chinese medicine oral-administration medicament, local common medicinal materials are mainly selected, so that the cost is low, and the economic burden for the patients is reduced.
Description
Technical field
The invention belongs to traditional Chinese medicine field, relate to a kind of extract oral medicament for the treatment of cholelithiasis and preparation method thereof.
Background technology
Cause of disease cholelithiasis is relevant with many factors.Anyly affect cholesterol and bile acid concentration ratio changes and cause the factor of cholestasis to cause calculus.Indivedual area and ethnic resident, estrogen, obesity, gestation, high fat diet, long-term parenteral, diabetes, hyperlipemia, pacing stomach or the factor such as gastrointestinal anastomosis Post operation, terminal ileum disease and ileal resection is postoperative, liver cirrhosis, hemolytic anemia all can cause cholelithiasis.Relatively high at the cholelithiasis sickness rate in NORTHWEST CHINA area, may be relevant with dietary habit.
Clinical manifestation most patient is asymptomatic, only health check-up, perform the operation and become celestial time find, be called inactive cholelithiasis.The classical symptom of the cholelithiasis of a few patients is biliary colic, shows as acute or chronic cholecystitis.Main clinical manifestation is as follows:
1. biliary colic: patient be everlasting heavy meal, feed greasy food after or sleep in Body Position Change time, because gallbladder contraction or calculus displacement add vagal excitation, Incarcerated stone is at gallbladder ampulla or cervical region, and gall bladder emptying is obstructed, IBP power raises, and gallbladder brute force is shunk and causes angor.Pain is positioned at upper right abdomen or epigastrium, in paroxysmal, or the aggravation of constant pain paroxysmal, can radiate in scapular region and back to the right, can Nausea and vomiting be accompanied.Some patients accurately can not say painful area because pain is acute.After biliary colic occurs first, the patient of about 70% can be recurred in 1 year.2. upper abdomen dull pain: most patient only on the feed excessive, feel epigastrium or upper right abdomen dull pain when eating high lipid food, work strain or have a rest bad, or there are glutted discomfort, belch, singultus etc., easily be misdiagnosed as " gastropathy " 3. gallbladder hydrops: the long-term incarceration of cholelithiasis or block cystic duct but non-concurrent infection time, gallbladder mucosa absorbs the bile pigments in bile.Secretion mucus material, forms gallbladder hydrops.Hydrops is transparent colourless, is also called white bile.4. other: (1) seldom causes jaundice, gentlier; (2) microlith enters in common bile duct by cystic duct becomes choledocholithiasis; (3) choledoch-calculus causes pancreatitis by Oddi sphincter incarceration in ampulla, is called Biliary pancreatitis; (4) because calculus compressing causes gallbladder inflammation and chronic perforation, can cause cholecystoduodenal fistula or cholecystocolonic fistula, large calculus enters intestinal by fistula and causes intestinal obstruction to be called gallstone intestinal obstruction; (5) calculus and long-term inflammatory stimulus can bring out carcinoma of gallbladder.5.Mirizzi syndrome: Mirizzi syndrome is the cholelithiasis of specific type, due to cystic duct and common hepatic duct, to accompany the long or cystic duct of row and common hepatic duct to converge position too low, continue incarceration in neck of gallbladder and larger calculus of cystic duct compressing common hepatic duct, cause common hepatic duct narrow, inflammatory episode repeatedly more causes gallbladder common hepatic duct fistula, and cystic duct disappears, calculus partly or entirely blocks common hepatic duct and causes.Clinical manifestation is recurrent exerbation cholecystitis and cholangitis, obvious obstructive jaundice.The visible gallbladder of biliary tract imaging examination or increase, common hepatic duct expansion, common bile duct are normal.
In the method for existing treatment cholelithiasis, Authorization Notice No. CN 102727837 B(application number 201210255916.2) patent discloses a kind of Chinese medicine composition for the treatment of cholelithiasis and chronic cholecystitis, its raw material is composed as follows: the Radix Paeoniae Alba 6-12 grams, Radix Bupleuri 3-6 grams, Fructus Aurantii 6-10 grams, Rhizoma Cyperi 6-12 grams, Herba Lysimachiae 10-30 grams, radix curcumae 6-10 grams, Rhizoma Polygoni Cuspidati 6-12 grams, Endothelium Corneum Gigeriae Galli 10-15 grams, Fructus Crataegi 6-12 grams, Radix Clematidis 10-30 grams, Radix Et Rhizoma Rhei 6-15 grams, Fructus Mume 10-30 grams, 6-12 grams, Talcum, 3-5 grams, Radix Glycyrrhizae.Authorization Notice No. CN 102512630 B(application number 201110437720.0) patent discloses a kind of Chinese medicine composition for the treatment of cholelithiasis, it is characterized in that: its raw material of Chinese medicine and weight proportion are: Herba Lysimachiae 60g, Spora Lygodii 60g, Endothelium Corneum Gigeriae Galli 20g, Radix Curcumae 15g, Radix Gentianae 15g, Radix Bupleuri 15g, Fructus Aurantii Immaturus 15g, Radix Et Rhizoma Rhei 10g, Rhizoma Atractylodis Macrocephalae 15g, Pericarpium Citri Reticulatae 12g, Rhizoma Pinelliae 12g, Radix Scutellariae 12g, Radix Codonopsis 15g.
Chinese medicine has good curative effect on treatment cholelithiasis as can be seen here, but in the medicine of current existing treatment cholelithiasis, general comparitive study is single, and therapeutic effect is also bad, extra burden can be caused to the health of patient, most importantly can not suit the taste of both old and young.
Summary of the invention
For the present situation of existing treatment cholelithiasis deficiency, an object of the present invention is to provide a kind of extract oral medicament for the treatment of cholelithiasis, have easy to carry, action effect is obvious, can be very fast play depressed liver-energy dispersing and function of gallbladder promoting, the effect of fossil calculus removing, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned extract oral medicament.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat an extract oral medicament for cholelithiasis, take off the primary raw material stating weight proportion and be prepared from: Radix Codonopsis 15-20 part, Maifanitum 4-8 part, Radix Bupleuri 18-25 part, Radix Clematidis 10-20 part, Rhizoma Dioscoreae 20-30 part, Herba Lysimachiae 30-40 part, Herba Sedi 15-30 part, Pericarpium Citri Reticulatae Viride 10-16 part, Semen Raphani 6-14 part, Endothelium Corneum Gigeriae Galli 15-28 part, Semen Coicis 10-20 part, Rhizoma Anemarrhenae 5-15 part, Fructus Aurantii Immaturus 3-8 part, Radix Gentianae 8-14 part.
Treat an extract oral medicament for cholelithiasis, optimum ratio, take off the primary raw material stating weight proportion and be prepared from: Radix Codonopsis 16-19 part, Maifanitum 5-7 part, Radix Bupleuri 20-22 part, Radix Clematidis 13-18 part, Rhizoma Dioscoreae 23-28 part, Herba Lysimachiae 33-38 part, Herba Sedi 31-34 part, Pericarpium Citri Reticulatae Viride 13.5-14.5 part, Semen Raphani 9.5-10.5 part, Endothelium Corneum Gigeriae Galli 23.5-24.5 part, Semen Coicis 13-18 part, Rhizoma Anemarrhenae 8-13 part, Fructus Aurantii Immaturus 4-7 part, Radix Gentianae 10-12 part.
Treat an extract oral medicament for cholelithiasis, better preferred proportioning, take off the primary raw material stating weight proportion and be prepared from: Radix Codonopsis 17.5 parts, Maifanitum 6 parts, Radix Bupleuri 21 parts, Radix Clematidis 15 parts, Rhizoma Dioscoreae 25 parts, Herba Lysimachiae 35 parts, Herba Sedi 32.5 parts, 14 parts, Pericarpium Citri Reticulatae Viride, Semen Raphani 10 parts, Endothelium Corneum Gigeriae Galli 24 parts, Semen Coicis 15 parts, the Rhizoma Anemarrhenae 11 parts, Fructus Aurantii Immaturus 5.5 parts, Radix Gentianae 11 parts.
The preparation method of above-mentioned extract oral medicament, step is as follows:
(1) by Rhizoma Dioscoreae and Semen Raphani peeling, cleaning 2-6 time, cuts into slices, is placed in clean plate stand-by;
(2) Maifanitum is smashed, cross 60-100 mesh sieve stand-by;
(3) first by Radix Codonopsis, Radix Bupleuri, Radix Clematidis, Herba Lysimachiae, Herba Sedi, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus and Radix Gentianae are cleaned, again electric food warmer is cleaned, add clear water, food steamer is soaked, be placed on grill pan, first by Radix Clematidis, Endothelium Corneum Gigeriae Galli and the Rhizoma Anemarrhenae are laid on food steamer, even with rice wine spray, 2-6 minute is steamed after water boils, place 40-60 DEG C, by Radix Codonopsis, Radix Bupleuri and Herba Lysimachiae are placed on steamed crude drug uniformly, even with rice vinegar spray, 1-5 minute is steamed after water boils, stewing after 10-20 minute, by Herba Sedi, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus and Radix Gentianae are placed on steamed crude drug, even with rice vinegar spray, 3-8 minute is steamed after water boils, air dry of drying in the air is done, grind to form smalls stand-by,
(4) Semen Coicis is placed in large iron pan, add Semen Coicis weight 30-40 warm water doubly, little fire decocts to boiling, turn big fire after 20-40 minute until boiling and decoct 2-4 minute, stewing 20-30 minute, filters, Semen Coicis is placed in close grenadine cloth, roll out moisture with rolling pin, Semen Coicis is fried to crisp, and it is stand-by to grind to form smalls;
(5) gained smalls in step (4) and step (1)-(3) gains are mixed, mix thoroughly with Mel, sealing 2-4 hour is wrapped with preservative film, step (4) gained filtrate is heated to 30-40 DEG C, put into the crude drug of good seal, stir while decoct 3-7 minute, filter, filtrate cools bottling and namely obtains medicinal preparation for oral administration.
Above-mentioned preparation method, step (1) is by Rhizoma Dioscoreae and Semen Raphani peeling, and cleaning 3-5 is all over (preferably by Rhizoma Dioscoreae and Semen Raphani peeling, cleaning 4 times).
Above-mentioned preparation method, Maifanitum is smashed by step (2), crosses 70-90 mesh sieve stand-by (preferably smashed by Maifanitum, cross 80 mesh sieves stand-by).
Above-mentioned preparation method, step (3) steams 3-5 minute after water boils, and places 45-55 DEG C (preferably steam 4 minutes after water boils, place 50 DEG C).
Above-mentioned preparation method, steams 2-4 minute after step (3) water boils, stewing 13-18 minute (preferred water is steamed 3 minutes after boiling, stewing 15 minutes).
Above-mentioned preparation method, step (4) adds Semen Coicis weight 33-38 warm water doubly, little fire decocts to boiling, turn big fire after 25-35 minute until boiling and decoct 2-4 minute, boil in a covered pot over a slow fire and (preferably add the warm water of Semen Coicis weight 35 times in 23-28 minute, little fire decocts to boiling, turns big fire decoct 3 minutes until boiling after 30 minutes, stewing 25 minutes).
Above-mentioned preparation method, step (5) is mixed thoroughly with Mel, wraps sealing 2.5-3.5 hour (preferably mix thoroughly with Mel, wrap sealing 3 hours with preservative film) with preservative film.
Using method: for making the present invention reach optimum therapeuticing effect, gained extract oral medicament, take after 1 hour after the meal three, with warm water delivery service, each 5-10ml 7 days is a course for the treatment of.
This extract oral medicament to the Be very effective of cholelithiasis, not only depressed liver-energy dispersing and function of gallbladder promoting, fossil calculus, can also stomach invigorating and in, inducing diuresis for treating stranguria syndrome, improves patient for a long time because of slight illness that cholelithiasis brings, and the local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
Treat an extract oral medicament for cholelithiasis, the pharmacological effect of each crude drug is respectively:
Radix Codonopsis: be usually used in gas Tianjin two and hinder or deficiency of both QI and blood.Radix Codonopsis sweet in the mouth, property is put down.Have invigorating the spleen and replenishing QI, quench the thirst, spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.[1] lazy speech lose heart, myasthenia of limbs, be off one's feed, the deficiency of vital energy, gas Tianjin two are empty, QI and blood is two loses and the disease such as blood deficiency and yellow complexion.But exterior syndrome is not separated and can not the using of the fullness in the epigastrium and abdomen domination of pathogen.This product effect is similar to Radix Ginseng, and only the efficacy of a drug is weak.
Maifanitum: be Acid-intermediate igneous rock rocks beschtauite.Composition: Maifanitum main component has silicon dioxide, aluminium oxide, ferrum oxide, ferrous oxide, magnesium oxide, calcium oxide, sodium oxide, potassium oxide, titanium dioxide, phosphorus pentoxide, manganese oxide, carbon dioxide, and the trace element such as fluorine, sulfur, strontium, barium, copper, zinc.The property of medicine: " detailed outline ": " sweet, temperature, nontoxic." function cures mainly: removing toxic substances and promoting granulation, damp eliminating spleen invigorating.Cure mainly carbuncle carbuncle on the back, acne, eczema, beriberi, miliaria, finger is chapped, chloasma, toothache, oral ulcer, rheumatic arthralgia, lumbago and backache, chronic hepatitis, gastritis, dysentery, diabetes, neurasthenia, wound is red and swollen, hypertension, senile sclerosis of blood vessels, tumor, lithangiuria.Generally make health product.
Radix Bupleuri: another name ground smoke, mountain dish, mushroom grass, faggot, nature and flavor hardship, be slightly cold, return liver, gallbladder meridian.There is reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.
Radix Clematidis: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, knee joint cold type of pain, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
Rhizoma Dioscoreae: Rhizoma Dioscoreae has and nourishes strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.
Herba Lysimachiae: Herba Lysimachiae has cholagogic and lithagogue and diuresis and expelling stone effect.The crystallization of polysaccharide component in the alcohol-insoluble substances of Herba Lysimachiae to the main component Calcium oxalate (CaC2O4) monohydrate CaC2O4H2O of lithangiuria has inhibitory action.And inhibitory action increases with the increase of concentration.Herba Lysimachiae also can make blood, urine slant acidity, makes the litholysis that could exist in alkaline environment.Slow down CaC2O4H2O growth rate, reduces the degree of crystal accumulation, thus be conducive to treating calculus.Obtained good result by modern clinic extensive use.Usually because Herba Lysimachiae can be used for, effect of clearing away heat and promoting diuresis calculus is soaked drinks when tea beverage the common people.
Herba Sedi: clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat; Gonorrhea; Dysentery; Lung abscess; Intestinal carbuncle; Furuncle toxic swelling; Snake bite and insect sting; Burn due to hot liquid or fire; Laryngopharynx swelling and pain; Oral ulcer and eczema; Herpes zoster.
Pericarpium Citri Reticulatae Viride: bitter in the mouth, pungent, warm in nature.Gui Jing returns liver, gallbladder, stomach warp.Function has soothing the liver dispelling the stagnated QI, effect that removing food stagnancyization is stagnant.
Cure mainly for distending pain in the chest and hypochondrium, hernia pain, nodules of the breast, acute mastitis, stagnation of QI due to dyspepsia, abdominal distention.
Semen Raphani: pungent, sweet, flat.Gui Jing returns lung, spleen, stomach warp.Effect helps digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
Endothelium Corneum Gigeriae Galli: be the gizzard tunica intima of Phasianidae Phasianus animal man chicken.Composition: Endothelium Corneum Gigeriae Galli contains pepsine, keratin, micro-pepsin, amylase, multivitamin.The chicken gizzard tunica intima in class origin 4-8 week also contains the yellow derivant etc. of bilitrien and biliverdin.The property of medicine: sweet, puckery, flat.Return spleen, stomach, urinary bladder channel.Function cures mainly: strengthening the spleen and stomach, helps digestion long-pending, fossil.Cure mainly food stagnation, have loose bowels, infantile malnutrition, cholelithiasis, stranguria caused by urinary stone, Sha Lin, lump in the abdomen amenorrhea, sore throat tonsillitis, ulcerative gingivitis aphtha.
Semen Coicis: containing coixenolide (coixenolide); And fatty oil, containing myristic acid (myristic acid), campesterol (campesterol), Palmic acid, 8-octadecenic acid, stigmasterol etc. in oil, still containing aminoacid, protein, saccharide.
Nature and flavor: cool in nature, sweet in the mouth, light, there is spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.For effect of edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.
The Rhizoma Anemarrhenae: this kind of dry root stock is famous Chinese medicine, property bitter cold, has nourishing YIN to lower pathogenic fire, moisturizes laxation, the effect of sharp defecation.Gunpowder under genus heat clearing away, cures mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.There is dividing of " RHIZOMA ANEMARRHENAE with peet " and " unpeeled RHIZOMA ANEMARRHENAE ".Main producing region is in Hebei.Chinese medicine is called: rabbit Herba Leptochloae Chinensis, great Lu water, Ma Macao, garlic clove grass, furuncle root, L.Lucidus Turcz. etc.
Fructus Aurantii Immaturus: meridian distribution of property and flavor: bitter; Pungent; Cold.Return spleen; Stomach; Liver; Heart channel.Effect: stop in stagnant; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.
Radix Gentianae: heat clearing and damp drying, eliminating pathogen in the liver is calmed the frightened, jaundice due to damp-heat; Urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear swells; Hypochondriac pain bitter taste; Calentura convulsion with spasms.
Extract oral medicament of the present invention meets the principle that disease treatment debated by Chinese medicine, therapeutic effect is comprehensive, and affected area administration is more rapid, lasting medicine, belong to the cholelithiasis prescription for the treatment of both the principal and secondary aspects of a disease, the Chinese medicinal material selected all has depressed liver-energy dispersing and function of gallbladder promoting, fossil calculus, stomach invigorating and in, effect of regulating the flow of Qi and the middle Jiao, and cheap, life-time service also can not cause the financial burden of patient, is to treat the ideal medicine of cholelithiasis.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat an extract oral medicament for cholelithiasis, take off the primary raw material stating weight proportion and be prepared from (getting 20g for every part): Radix Codonopsis 15 parts, Maifanitum 4 parts, Radix Bupleuri 18 parts, Radix Clematidis 10 parts, Rhizoma Dioscoreae 20 parts, Herba Lysimachiae 30 parts, Herba Sedi 15 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Semen Raphani 6 parts, Endothelium Corneum Gigeriae Galli 15 parts, Semen Coicis 10 parts, the Rhizoma Anemarrhenae 5 parts, Fructus Aurantii Immaturus 3 parts, Radix Gentianae 8 parts.
The preparation method of above-mentioned extract oral medicament, step is:
(1) by Rhizoma Dioscoreae and Semen Raphani peeling, clean 2 times, cut into slices, be placed in clean plate stand-by;
(2) Maifanitum is smashed, cross 60 mesh sieves stand-by;
(3) first by Radix Codonopsis, Radix Bupleuri, Radix Clematidis, Herba Lysimachiae, Herba Sedi, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus and Radix Gentianae are cleaned, again electric food warmer is cleaned, add clear water, food steamer is soaked, be placed on grill pan, first by Radix Clematidis, Endothelium Corneum Gigeriae Galli and the Rhizoma Anemarrhenae are laid on food steamer, even with rice wine spray, steam 2 minutes after water boils, place 40 DEG C, by Radix Codonopsis, Radix Bupleuri and Herba Lysimachiae are placed on steamed crude drug uniformly, even with rice vinegar spray, steam 1 minute after water boils, stewing after 10 minutes, by Herba Sedi, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus and Radix Gentianae are placed on steamed crude drug, even with rice vinegar spray, steam 3 minutes after water boils, air dry of drying in the air is done, grind to form smalls stand-by,
(4) Semen Coicis is placed in large iron pan, add the warm water of Semen Coicis weight 30 times, little fire decocts to boiling, turn big fire after 20 minutes until boiling and decoct 2 minutes, stewing 20 minutes, filter, Semen Coicis is placed in close grenadine cloth, roll out moisture with rolling pin, Semen Coicis is fried to crisp, and it is stand-by to grind to form smalls;
(5) gained smalls in step (4) and step (1)-(3) gains are mixed, mix thoroughly with Mel, sealing is wrapped 2 hours with preservative film, step (4) gained filtrate is heated to 30 DEG C, put into the crude drug of good seal, stir while decoct 3 minutes, filter, filtrate cools bottling and namely obtains medicinal preparation for oral administration.
typical case one:zou XX, female, 42 years old, suffers from cholelithiasis more than 4 years, often feels that right upper quadrant of the abdomen pain is uncomfortable, and have constriction, companion's inappetence, feel sick, abdominal distention etc., idol has biliary colic to show effect, and doctor advised takes gained medicinal preparation for oral administration of the present invention.
Take embodiment 1 gained medicinal preparation for oral administration, after 1 course for the treatment of, symptom is clearly better; Continue and take 1 course for the treatment of, B super inspection calculus quantity, size obviously reduce, and continue again to take 1 course for the treatment of, malaise symptoms all disappears, and patients after withdrawal is not recurred always.
embodiment 2treat an extract oral medicament for cholelithiasis, take off the primary raw material stating weight proportion and be prepared from (getting 10g for every part): Radix Codonopsis 20 parts, Maifanitum 8 parts, Radix Bupleuri 25 parts, Radix Clematidis 20 parts, Rhizoma Dioscoreae 30 parts, Herba Lysimachiae 40 parts, Herba Sedi 30 parts, 16 parts, Pericarpium Citri Reticulatae Viride, Semen Raphani 14 parts, Endothelium Corneum Gigeriae Galli 28 parts, Semen Coicis 20 parts, the Rhizoma Anemarrhenae 15 parts, Fructus Aurantii Immaturus 8 parts, Radix Gentianae 14 parts.
The preparation method of above-mentioned extract oral medicament, step is:
(1) by Rhizoma Dioscoreae and Semen Raphani peeling, clean 6 times, cut into slices, be placed in clean plate stand-by;
(2) Maifanitum is smashed, cross 100 mesh sieves stand-by;
(3) first by Radix Codonopsis, Radix Bupleuri, Radix Clematidis, Herba Lysimachiae, Herba Sedi, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus and Radix Gentianae are cleaned, again electric food warmer is cleaned, add clear water, food steamer is soaked, be placed on grill pan, first by Radix Clematidis, Endothelium Corneum Gigeriae Galli and the Rhizoma Anemarrhenae are laid on food steamer, even with rice wine spray, steam 6 minutes after water boils, place 60 DEG C, by Radix Codonopsis, Radix Bupleuri and Herba Lysimachiae are placed on steamed crude drug uniformly, even with rice vinegar spray, steam 5 minutes after water boils, stewing after 20 minutes, by Herba Sedi, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus and Radix Gentianae are placed on steamed crude drug, even with rice vinegar spray, steam 8 minutes after water boils, air dry of drying in the air is done, grind to form smalls stand-by,
(4) Semen Coicis is placed in large iron pan, add the warm water of Semen Coicis weight 40 times, little fire decocts to boiling, turn big fire after 40 minutes until boiling and decoct 4 minutes, stewing 30 minutes, filter, Semen Coicis is placed in close grenadine cloth, roll out moisture with rolling pin, Semen Coicis is fried to crisp, and it is stand-by to grind to form smalls;
(5) gained smalls in step (4) and step (1)-(3) gains are mixed, mix thoroughly with Mel, sealing is wrapped 4 hours with preservative film, step (4) gained filtrate is heated to 40 DEG C, put into the crude drug of good seal, stir while decoct 7 minutes, filter, filtrate cools bottling and namely obtains medicinal preparation for oral administration.
embodiment 3treat an extract oral medicament for cholelithiasis, take off the primary raw material stating weight proportion and be prepared from (getting 20g for every part): Radix Codonopsis 16 parts, Maifanitum 5 parts, Radix Bupleuri 20 parts, Radix Clematidis 13 parts, Rhizoma Dioscoreae 23 parts, Herba Lysimachiae 33 parts, Herba Sedi 31 parts, 13.5 parts, Pericarpium Citri Reticulatae Viride, Semen Raphani 9.5 parts, Endothelium Corneum Gigeriae Galli 23.5 parts, Semen Coicis 13 parts, the Rhizoma Anemarrhenae 8 parts, Fructus Aurantii Immaturus 4 parts, Radix Gentianae 10 parts.
The preparation method of above-mentioned extract oral medicament, step is:
(1) by Rhizoma Dioscoreae and Semen Raphani peeling, clean 3 times, cut into slices, be placed in clean plate stand-by;
(2) Maifanitum is smashed, cross 70 mesh sieves stand-by;
(3) first by Radix Codonopsis, Radix Bupleuri, Radix Clematidis, Herba Lysimachiae, Herba Sedi, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus and Radix Gentianae are cleaned, again electric food warmer is cleaned, add clear water, food steamer is soaked, be placed on grill pan, first by Radix Clematidis, Endothelium Corneum Gigeriae Galli and the Rhizoma Anemarrhenae are laid on food steamer, even with rice wine spray, steam 3 minutes after water boils, place 45 DEG C, by Radix Codonopsis, Radix Bupleuri and Herba Lysimachiae are placed on steamed crude drug uniformly, even with rice vinegar spray, steam 2 minutes after water boils, stewing after 13 minutes, by Herba Sedi, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus and Radix Gentianae are placed on steamed crude drug, even with rice vinegar spray, steam 5 minutes after water boils, air dry of drying in the air is done, grind to form smalls stand-by,
(4) Semen Coicis is placed in large iron pan, add the warm water of Semen Coicis weight 33 times, little fire decocts to boiling, turn big fire after 25 minutes until boiling and decoct 2 minutes, stewing 23 minutes, filter, Semen Coicis is placed in close grenadine cloth, roll out moisture with rolling pin, Semen Coicis is fried to crisp, and it is stand-by to grind to form smalls;
(5) gained smalls in step (4) and step (1)-(3) gains are mixed, mix thoroughly with Mel, sealing 2-4 hour is wrapped with preservative film, step (4) gained filtrate is heated to 30-40 DEG C, put into the crude drug of good seal, stir while decoct 3-7 minute, filter, filtrate cools bottling and namely obtains medicinal preparation for oral administration.
typical case two:what XX, man, 55 years old, patients head's xerostomia, hardship, the frequent pain of left lumbar, spleen, left side is frequent pain also, and body is thin, yellowish complexion, anemia.B is super to be checked: cholelithiasis, doctor advised takes gained medicinal preparation for oral administration of the present invention.
Take embodiment 3 gained medicinal preparation for oral administration, after 1 course for the treatment of, symptom is clearly better; Continue and take 1 course for the treatment of, B super inspection calculus quantity, size obviously reduce, and continue again to take 1 course for the treatment of, malaise symptoms all disappears, and patients after withdrawal is not recurred always.
embodiment 4treat an extract oral medicament for cholelithiasis, take off the primary raw material stating weight proportion and be prepared from (getting 15g for every part): Radix Codonopsis 19 parts, Maifanitum 7 parts, Radix Bupleuri 22 parts, Radix Clematidis 18 parts, Rhizoma Dioscoreae 28 parts, Herba Lysimachiae 38 parts, Herba Sedi 34 parts, 14.5 parts, Pericarpium Citri Reticulatae Viride, Semen Raphani 10.5 parts, Endothelium Corneum Gigeriae Galli 24.5 parts, Semen Coicis 18 parts, the Rhizoma Anemarrhenae 13 parts, Fructus Aurantii Immaturus 7 parts, Radix Gentianae 12 parts.
The preparation method of above-mentioned extract oral medicament, step is:
(1) by Rhizoma Dioscoreae and Semen Raphani peeling, clean 5 times, cut into slices, be placed in clean plate stand-by;
(2) Maifanitum is smashed, cross 90 mesh sieves stand-by;
(3) first by Radix Codonopsis, Radix Bupleuri, Radix Clematidis, Herba Lysimachiae, Herba Sedi, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus and Radix Gentianae are cleaned, again electric food warmer is cleaned, add clear water, food steamer is soaked, be placed on grill pan, first by Radix Clematidis, Endothelium Corneum Gigeriae Galli and the Rhizoma Anemarrhenae are laid on food steamer, even with rice wine spray, steam 5 minutes after water boils, place 55 DEG C, by Radix Codonopsis, Radix Bupleuri and Herba Lysimachiae are placed on steamed crude drug uniformly, even with rice vinegar spray, 1-5 minute is steamed after water boils, stewing after 18 minutes, by Herba Sedi, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus and Radix Gentianae are placed on steamed crude drug, even with rice vinegar spray, steam 7 minutes after water boils, air dry of drying in the air is done, grind to form smalls stand-by,
(4) Semen Coicis is placed in large iron pan, add the warm water of Semen Coicis weight 38 times, little fire decocts to boiling, turn big fire after 35 minutes until boiling and decoct 4 minutes, stewing 28 minutes, filter, Semen Coicis is placed in close grenadine cloth, roll out moisture with rolling pin, Semen Coicis is fried to crisp, and it is stand-by to grind to form smalls;
(5) gained smalls in step (4) and step (1)-(3) gains are mixed, mix thoroughly with Mel, sealing is wrapped 3.5 hours with preservative film, step (4) gained filtrate is heated to 38 DEG C, put into the crude drug of good seal, stir while decoct 6 minutes, filter, filtrate cools bottling and namely obtains medicinal preparation for oral administration.
embodiment 5treat an extract oral medicament for cholelithiasis, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): Radix Codonopsis 17.5 parts, Maifanitum 6 parts, Radix Bupleuri 21 parts, Radix Clematidis 15 parts, Rhizoma Dioscoreae 25 parts, Herba Lysimachiae 35 parts, Herba Sedi 32.5 parts, 14 parts, Pericarpium Citri Reticulatae Viride, Semen Raphani 10 parts, Endothelium Corneum Gigeriae Galli 24 parts, Semen Coicis 15 parts, the Rhizoma Anemarrhenae 11 parts, Fructus Aurantii Immaturus 5.5 parts, Radix Gentianae 11 parts.
(1) by Rhizoma Dioscoreae and Semen Raphani peeling, clean 4 times, cut into slices, be placed in clean plate stand-by;
(2) Maifanitum is smashed, cross 80 mesh sieves stand-by;
(3) first by Radix Codonopsis, Radix Bupleuri, Radix Clematidis, Herba Lysimachiae, Herba Sedi, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus and Radix Gentianae are cleaned, again electric food warmer is cleaned, add clear water, food steamer is soaked, be placed on grill pan, first by Radix Clematidis, Endothelium Corneum Gigeriae Galli and the Rhizoma Anemarrhenae are laid on food steamer, even with rice wine spray, steam 4 minutes after water boils, place 50 DEG C, by Radix Codonopsis, Radix Bupleuri and Herba Lysimachiae are placed on steamed crude drug uniformly, even with rice vinegar spray, steam 3 minutes after water boils, stewing after 15 minutes, by Herba Sedi, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus and Radix Gentianae are placed on steamed crude drug, even with rice vinegar spray, steam 5 minutes after water boils, air dry of drying in the air is done, grind to form smalls stand-by,
(4) Semen Coicis is placed in large iron pan, add the warm water of Semen Coicis weight 35 times, little fire decocts to boiling, turn big fire after 30 minutes until boiling and decoct 3 minutes, stewing 25 minutes, filter, Semen Coicis is placed in close grenadine cloth, roll out moisture with rolling pin, Semen Coicis is fried to crisp, and it is stand-by to grind to form smalls;
(5) gained smalls in step (4) and step (1)-(3) gains are mixed, mix thoroughly with Mel, sealing is wrapped 3 hours with preservative film, step (4) gained filtrate is heated to 35 DEG C, put into the crude drug of good seal, stir while decoct 5 minutes, filter, filtrate cools bottling and namely obtains medicinal preparation for oral administration.
test example 1the clinical practice of the extract oral medicament of embodiment 5 gained treatment cholelithiasis: screen 200 routine patients in 4 hospitals, oldest 45 years old, minimal ages 20 years old, 32 years old mean age.Before test 1 week, carry out Continuous Observation to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine.
Using method is: gained extract oral medicament, and take after 1 hour after the meal three, with warm water delivery service, each 5-10ml 7 days is a course for the treatment of.
Curative effect situation criterion: cure: after taking and using this product, malaise symptoms has clear improvement, and pain disappears substantially; Effective: after taking and using this product, malaise symptoms makes moderate progress, and pain alleviates to some extent; Invalid: after taking and using this product, malaise symptoms is unchanged.Result is as shown in table 1-2.
Table 1
Therapeutic effect: take extract oral medicament effective percentage 98% of the present invention, exceed 23% than matched group.Successful is better than matched group.
Table 2:
| Group | Drug categories | Case load (people) | The patient oneself status evaluation that cholelithiasis is serious |
| Matched group | Take the medicine of other treatment cholelithiasis | 100 | After the patient of more than 50% thinks and takes this medicine, health is large by burden, neural and health is all very painful, and costly |
| Experimental group | Take extract oral medicament of the present invention | 100 | The people of more than 85% thinks, after taking this product, health is good, and have no adverse reaction, treating both the principal and secondary aspects of a disease, and low price, can accept |
Prove through clinical trial, compared with taking extract oral medicament of the present invention and taking the medicine of other treatment cholelithiasis, control recurrence rate after healing low, treatment means is more comprehensive thoroughly, have no side effect between the operating period, while treatment cholelithiasis, the symptoms such as the pain brought by cholelithiasis can be alleviated.Prove through clinical trial, extract oral medicament effective percentage 98% of the present invention, most of gallstone patients was medication about 5 days, and pain symptom has and obviously alleviates, and extract oral medicament of the present invention is a kind of medicine for the treatment of cholelithiasis safely and effectively.
Claims (10)
1. treat an extract oral medicament for cholelithiasis, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Codonopsis 15-20 part, Maifanitum 4-8 part, Radix Bupleuri 18-25 part, Radix Clematidis 10-20 part, Rhizoma Dioscoreae 20-30 part, Herba Lysimachiae 30-40 part, Herba Sedi 15-30 part, Pericarpium Citri Reticulatae Viride 10-16 part, Semen Raphani 6-14 part, Endothelium Corneum Gigeriae Galli 15-28 part, Semen Coicis 10-20 part, Rhizoma Anemarrhenae 5-15 part, Fructus Aurantii Immaturus 3-8 part, Radix Gentianae 8-14 part.
2. the extract oral medicament for the treatment of cholelithiasis according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Codonopsis 16-19 part, Maifanitum 5-7 part, Radix Bupleuri 20-22 part, Radix Clematidis 13-18 part, Rhizoma Dioscoreae 23-28 part, Herba Lysimachiae 33-38 part, Herba Sedi 31-34 part, Pericarpium Citri Reticulatae Viride 13.5-14.5 part, Semen Raphani 9.5-10.5 part, Endothelium Corneum Gigeriae Galli 23.5-24.5 part, Semen Coicis 13-18 part, Rhizoma Anemarrhenae 8-13 part, Fructus Aurantii Immaturus 4-7 part, Radix Gentianae 10-12 part.
3. the extract oral medicament for the treatment of cholelithiasis according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Codonopsis 17.5 parts, Maifanitum 6 parts, Radix Bupleuri 21 parts, Radix Clematidis 15 parts, Rhizoma Dioscoreae 25 parts, Herba Lysimachiae 35 parts, Herba Sedi 32.5 parts, 14 parts, Pericarpium Citri Reticulatae Viride, Semen Raphani 10 parts, Endothelium Corneum Gigeriae Galli 24 parts, Semen Coicis 15 parts, the Rhizoma Anemarrhenae 11 parts, Fructus Aurantii Immaturus 5.5 parts, Radix Gentianae 11 parts.
4. the preparation method of the extract oral medicament of the treatment cholelithiasis according to any one of claim 1-3, is characterized in that: step is as follows:
(1) by Rhizoma Dioscoreae and Semen Raphani peeling, cleaning 2-6 time, cuts into slices, is placed in clean plate stand-by;
(2) Maifanitum is smashed, cross 60-100 mesh sieve stand-by;
(3) first by Radix Codonopsis, Radix Bupleuri, Radix Clematidis, Herba Lysimachiae, Herba Sedi, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus and Radix Gentianae are cleaned, again electric food warmer is cleaned, add clear water, food steamer is soaked, be placed on grill pan, first by Radix Clematidis, Endothelium Corneum Gigeriae Galli and the Rhizoma Anemarrhenae are laid on food steamer, even with rice wine spray, 2-6 minute is steamed after water boils, place 40-60 DEG C, by Radix Codonopsis, Radix Bupleuri and Herba Lysimachiae are placed on steamed crude drug uniformly, even with rice vinegar spray, 1-5 minute is steamed after water boils, stewing after 10-20 minute, by Herba Sedi, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus and Radix Gentianae are placed on steamed crude drug, even with rice vinegar spray, 3-8 minute is steamed after water boils, air dry of drying in the air is done, grind to form smalls stand-by,
(4) Semen Coicis is placed in large iron pan, add Semen Coicis weight 30-40 warm water doubly, little fire decocts to boiling, turn big fire after 20-40 minute until boiling and decoct 2-4 minute, stewing 20-30 minute, filters, Semen Coicis is placed in close grenadine cloth, roll out moisture with rolling pin, Semen Coicis is fried to crisp, and it is stand-by to grind to form smalls;
(5) gained smalls in step (4) and step (1)-(3) gains are mixed, mix thoroughly with Mel, sealing 2-4 hour is wrapped with preservative film, step (4) gained filtrate is heated to 30-40 DEG C, put into the crude drug of good seal, stir while decoct 3-7 minute, filter, filtrate cools bottling and namely obtains medicinal preparation for oral administration.
5. preparation method according to claim 4, is characterized in that: step (1) is by Rhizoma Dioscoreae and Semen Raphani peeling, and cleaning 3-5 is all over (preferably by Rhizoma Dioscoreae and Semen Raphani peeling, cleaning 4 times).
6. preparation method according to claim 4, is characterized in that: Maifanitum is smashed by step (2), crosses 70-90 mesh sieve stand-by (preferably smashed by Maifanitum, cross 80 mesh sieves stand-by).
7. preparation method according to claim 4, is characterized in that: step (3) steams 3-5 minute after water boils, and places 45-55 DEG C (preferably steam 4 minutes after water boils, place 50 DEG C).
8. preparation method according to claim 4, is characterized in that: steam 2-4 minute after step (3) water boils, stewing 13-18 minute (preferred water is steamed 3 minutes after boiling, stewing 15 minutes).
9. preparation method according to claim 4, it is characterized in that: step (4) adds Semen Coicis weight 33-38 warm water doubly, little fire decocts to boiling, turn big fire after 25-35 minute until boiling and decoct 2-4 minute, boil in a covered pot over a slow fire and (preferably add the warm water of Semen Coicis weight 35 times in 23-28 minute, little fire decocts to boiling, turns big fire decoct 3 minutes until boiling after 30 minutes, stewing 25 minutes).
10. preparation method according to claim 4, is characterized in that: step (5) is mixed thoroughly with Mel, wraps sealing 2.5-3.5 hour (preferably mix thoroughly with Mel, wrap sealing 3 hours with preservative film) with preservative film.
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