CN110694032A - A Chinese medicinal composition for treating cholelithiasis, nephrolithiasis, and vesical calculus, and its preparation method - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 48-55 parts of purple gentian root, 202 parts of chicken's gizzard-membrane 196, 18-22 parts of elecampane, 30-32 parts of green tangerine peel, 9-12 parts of szechwan chinaberry fruit, 38-42 parts of turmeric root-tuber, 18-22 parts of raw hawthorn fruit, 18-22 parts of starwort root, 38-42 parts of desmodium styracifolium, 78-84 parts of desmodium styracifolium, 38-43 parts of medlar, 19-20 parts of immature bitter orange and 20-22 parts of rhizoma sparganii. The medicine has reasonable and precise compatibility, conforms to the principle of monarch, minister, assistant and guide, conforms to the pathogenesis of gallstones, kidney stones and bladder stones, has the functions of benefiting gallbladder and removing stones, detoxifying and resisting inflammation, and has the functions of promoting qi circulation and relieving depression, thereby being suitable for patients with various gallstones, kidney stones and bladder stones.

Description

A Chinese medicinal composition for treating cholelithiasis, nephrolithiasis, and vesical calculus, and its preparation method

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones and a preparation method thereof.

Background

Gallstones are common diseases of biliary systems, and the incidence rate of gallstones in China can reach 7-12% with the age, which is common in clinic. Gallstone diseases are complicated in cause and pathogenesis, and the gallstones are divided into peribiliary involutes 37241, cholechromic stones, uric acid stones, oxalic acid stones, gallstones, extravasated blood stones, sputum nucleus stones, gallbladder obstruction stones, gallbladder stagnation stones, metabolic stones, sandstone stones and the like in traditional Chinese medicine.

The stimulation of factors such as diet disorder, cold and warm discomfort, emotional injury and the like can cause the liver and gallbladder of a person to lose regulation and catharsis, so that damp-heat is generated in the body and the qi activity is not smooth; decocting bile into stone for a long time; the further development of cholelithiasis due to retention of damp-heat may cause toxic heat in the body, yellow skin by toxic heat or fumigation, or deep-seated nutrient-blood syncope, causing systemic critical symptoms.

The occurrence of gallstones is related to factors such as individual differences, self-response, medication, disease, environment, diet of patients, and the like. The treatment of gallstones is also carried out according to specific causes, and the treatment effect can be optimal.

The common treatment for gallstones is lithotripsy, but the cause of the gallstones is not removed by the treatment, so that the recurrence of the gallstones is not surprising. The problem of unclean calculus can occur due to the addition of surgery and calculus crushing, and the diet remained in the body is also the main reason of relapse. Gradually grow larger over time, resulting in relapse. The invention explains and treats gallstones, kidney stones and bladder stones from the perspective of traditional Chinese medicine, so as to reduce pain of stone patients.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones and a preparation method thereof, and aims to solve the technical problems in the background.

In order to achieve the purpose, the invention adopts the following technical scheme:

a traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones comprises the following raw material medicines in parts by weight: 48-55 parts of gentian root, 202 parts of chicken's gizzard-membrane 196, 18-22 parts of costustoot, 30-32 parts of green tangerine peel, 9-12 parts of szechwan chinaberry fruit, 38-42 parts of turmeric root-tuber, 18-22 parts of raw hawthorn fruit, 18-22 parts of starwort root, 38-42 parts of desmodium styracifolium, 78-84 parts of desmodium styracifolium, 38-43 parts of medlar, 19-20 parts of immature bitter orange and 20-22 parts of common burreed rhizome.

Preferably, the traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones comprises the following raw materials in parts by weight: 50 parts of gentian root, 200 parts of endothelium corneum gigeriae galli, 20 parts of costustoot, 30 parts of green tangerine peel, 10 parts of szechwan chinaberry fruit, 40 parts of radix curcumae, 20 parts of raw hawthorn, 20 parts of starwort root, 40 parts of desmodium styracifolium, 80 parts of desmodium styracifolium, 40 parts of medlar, 20 parts of immature bitter orange and 20 parts of rhizoma sparganii.

The second purpose of the invention is to provide a preparation method of the traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones, which comprises the following steps:

s1, weighing 48-55 parts of purple gentian root, 202 parts of chicken' S gizzard-membrane 196-one, 18-22 parts of elecampane, 30-32 parts of green skin, 38-42 parts of radix curcumae, 18-22 parts of raw hawthorn, 38-42 parts of desmodium styracifolium, 78-84 parts of desmodium styracifolium, 38-43 parts of medlar, 19-20 parts of immature bitter orange and 20-22 parts of rhizoma sparganii, putting the raw materials into a marmite, adding water, decocting for 30-45min, removing dregs of a decoction, and keeping the liquid medicine for later use;

s2, weighing 9-12 parts of szechwan chinaberry fruit, adding 2-6 parts of salt, frying at 50-60 ℃ for 10-15min, and grinding into powder for later use;

s3, weighing 18-22 parts of starwort root, adding 4-5 parts of auxiliary material mature vinegar, placing in a closed container, stewing for 60min, then frying in a pan at 70-80 ℃ for 20min, taking out, drying in the air, grinding into powder for later use;

s4, adding the fructus Toosendan (S2) and radix Stellariae (S3) into the liquid medicine (S1), and mixing.

Preferably, in the preparation method, the water addition amount is 800-1400 parts by weight

The prescription of the invention is compatible:

purple gentian root:

the functional indications are as follows: clear heat and dry dampness, purge liver and arrest convulsion. Jaundice due to damp-heat; pain in urination; swelling and itching of the vulva; damp-heat leucorrhea; headache due to liver-gallbladder fire; conjunctival congestion with swelling and pain; deaf and swollen ears; hypochondriac pain and bitter taste in the mouth; convulsion due to febrile disease.

Endothelium corneum gigeriae galli:

the functional indications are as follows: remove food stagnation, strengthen spleen and stomach. It is used to treat dyspepsia, emesis, regurgitation, dysentery, malnutritional stagnation, diabetes, enuresis, pharyngitis, tonsillitis, ulcerative gingivitis, and aphtha.

Costustoot:

the functional indications are as follows: promoting qi circulation and relieving pain; to regulate the middle energizer and remove food stagnation. Hypochondriac distention in the main cell is satisfied; abdominal distending pain; belching, vomiting and diarrhea; severe after dysentery. Can be used for treating chest and abdominal pain, dysentery, tenesmus, dyspepsia, and anorexia; the middle-jiao energy is not saved; sudden deafness; biting by snake and insect; toothache.

The pharmacological action is as follows: has effects on respiratory system, intestinal tract, cardiovascular and antibacterial effects.

Green tangerine peel:

the functional indications are as follows: soothe the liver and break qi, dissipate nodulation and resolve phlegm. It is indicated for pain in chest, hypochondrium, stomach and epigastrium, hernia, indigestion, breast swelling, breast nodule and chronic malaria.

The pharmacological action is as follows: dispelling phlegm and relieving asthma, and can be used for treating smooth muscle, increasing blood pressure, and resisting shock.

Toosendan fruit:

chuan Lian Zi has the actions of promoting qi circulation, alleviating pain and killing parasites, and has the actions of being slightly toxic, cold in nature and bitter in taste, entering liver meridian, stomach meridian, small intestine meridian and bladder meridian. Can be used for treating chest and abdomen pain caused by stagnation of qi due to stagnation of liver-qi or fire due to stagnation of liver-qi. Can also be used for treating qi pain of liver and stomach, hernia of heat and abdominal pain, and hernia of cold and abdominal pain.

Turmeric root-tuber:

the functional indications are as follows: move qi and relieve depression, cool blood and break blood stasis. It is indicated for pain in chest, abdomen and hypochondrium, mania due to loss of heart, coma due to fever, hematemesis, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, and jaundice.

Raw hawthorn:

the raw hawthorn is sour and sweet, and is slightly warm and not hot. Has effects in promoting digestion, invigorating stomach, promoting blood circulation, dispelling blood stasis, and relieving dysentery. Has good effects on lower abdominal pain, occasional dyspepsia, food retention, abdominal distension, gastric acid regurgitation, excessive phlegm, puerperal lochiorrhea, hypertension and hyperlipidemia. Can enhance immunity and resist aging after long-term consumption.

Radix Stellariae:

radix Stellariae, sweet in nature and taste, slightly cold, enters liver and stomach meridians, and has the functions of reducing deficiency heat and clearing liver heat. Clinically, it is usually combined with Qing Hao, Bie Jia and Di Gu Pi for yin deficiency fever, tidal fever and steaming bone and night sweat. Radix Stellariae may also be used for infantile malnutrition symptom, manifested as persistent low fever, thirst, restlessness, emaciation, etc., and is often combined with Zhi Zi, Hu Huang Lian, Bai Zhu, Ji Nei jin, etc. to clear heat and eliminate infantile malnutrition. Radix Stellariae can be used for treating chronic malaria due to yin deficiency. Radix Stellariae has effects of clearing heat and cooling blood, and can be used for treating pulmonary tuberculosis in late stage, hectic fever and hectic fever.

Herba Desmodii Styracifolii:

promoting qi circulation, promoting blood circulation, and removing food retention: can be clinically used for treating symptoms such as infantile malnutrition, renal and bladder calculus, cough, acute mastitis and the like. 2. The stone removing effect is as follows: herba Desmodii Styracifolii has effects of promoting bile flow, and removing urinary calculus, and can be used for treating diseases such as renal calculus and vesical calculus. 3. Anti-inflammatory efficacy: herba Desmodii Styracifolii has remarkable pathogenic bacteria inhibiting effect, and can be used for treating stomatitis, laryngitis, mastitis, nephritis, orchitis, etc. 4, the efficacies of clearing heat and removing dampness, and inducing diuresis for treating stranguria: can be used for treating conjunctival congestion, swelling and pain, blurred vision, difficulty in urination, edema due to kidney deficiency, etc. caused by liver fire hyperactivity.

Herba Desmodii Styracifolii:

the functional indications are as follows: clearing away heat, promoting diuresis, relieving swelling and removing toxic substances.

Wolfberry fruit:

the functional indications are as follows: nourishing liver and kidney, replenishing vital essence and improving eyesight.

The pharmacological action is as follows: influence on immune function, effect on spleen antibody cell number, blood sugar lowering effect, fatty liver resisting effect, blood pressure lowering effect, fructus Lycii extractive solution, anti-tumor effect, and other effects.

Immature bitter orange:

the functional indications are as follows: stagnation is caused internally; fullness and distending pain; constipation; severe diarrhea and dysentery; forming a breast; gastroptosis; uterine prolapse; rectocele.

The pharmacological action is as follows: and (4) effects on cardiovascular system. The effects on stomach and intestine, uterus, central nerve, diuresis and others.

Immature bitter orange:

the functional indications are as follows: break blood, move qi, resolve food stagnation and alleviate pain. It is used to treat abdominal pain, abdominal distention, amenorrhea, postpartum abdominal pain due to blood stasis, traumatic injury, stagnation of qi and blood, and pain in heart and abdomen.

The invention follows the principle of treatment based on syndrome differentiation, takes the root of gentian, endothelium corneum gigeriae galli, desmodium styracifolium, longhairy antenoron herb and four medicines as monarch medicines together, and has the effects of clearing heat and drying dampness, promoting qi circulation and relieving depression, activating blood circulation, detoxifying and resisting inflammation; the four medicaments of costustoot, green tangerine peel, szechwan chinaberry fruit and turmeric root-tuber are taken as ministerial medicaments, and the effects of relieving pain, soothing the liver, cooling blood and removing blood stasis are enhanced on the basis of strengthening monarch medicaments; raw hawthorn, starwort root and medlar are used as adjuvant drugs, aiming at strengthening monarch drugs and ministerial drugs; the immature bitter orange and the immature bitter orange are used as guiding medicaments together, so that the toxicity can be reduced, the toxic and side effects can be reduced, and the effects of monarch medicaments and ministerial medicaments can be enhanced; the medicines are combined to play the roles of benefiting gallbladder, removing stones, detoxifying and resisting inflammation.

The invention has the beneficial effects that:

1. the traditional Chinese medicine composition disclosed by the invention is reasonable and precise in compatibility, accords with the principle of 'monarch, minister, assistant and guide' and accords with the pathogenesis of gall, kidney and bladder calculi.

2. The traditional Chinese medicine composition disclosed by the invention has the advantages of benefiting gallbladder and removing stones, detoxifying and resisting inflammation, and promoting qi circulation and relieving depression, and is suitable for patients with various gallstones, kidney stones and bladder stones.

3. The traditional Chinese medicine composition has a remarkable treatment effect.

Detailed Description

The present invention is described in detail below with reference to specific examples, but the present invention should not be construed as being limited thereto. The technical means used in the following examples are conventional means well known to those skilled in the art, and materials, reagents and the like used in the following examples are commercially available unless otherwise specified.

Example 1

A traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones comprises the following raw material medicines in parts by weight: 48 parts of purple gentian root, 196 parts of chicken's gizzard-membrane, 18 parts of costustoot, 30 parts of green tangerine peel, 9 parts of szechwan chinaberry fruit, 38 parts of melancholy, 18 parts of raw hawthorn, 18 parts of starwort root, 38 parts of desmodium styracifolium, 78 parts of desmodium styracifolium, 38 parts of medlar, 19 parts of immature bitter orange and 20 parts of common burreed rhizome.

Example 2

A traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones comprises the following raw material medicines in parts by weight: 55 parts of purple gentian root, 202 parts of endothelium corneum gigeriae galli, 22 parts of elecampane, 32 parts of green tangerine peel, 12 parts of szechwan chinaberry fruit, 42 parts of radix curcumae, 22 parts of raw hawthorn, 22 parts of starwort root, 42 parts of desmodium styracifolium, 84 parts of desmodium styracifolium, 43 parts of boxthorn fruit, 20 parts of immature bitter orange and 22 parts of rhizoma sparganii.

Example 3

A traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones comprises the following raw material medicines in parts by weight: 50 parts of purple gentian root, 200 parts of endothelium corneum gigeriae galli, 20 parts of costustoot, 30 parts of green tangerine peel, 10 parts of szechwan chinaberry fruit, 40 parts of turmeric root-tuber, 20 parts of raw hawthorn fruit, 20 parts of starwort root, 40 parts of desmodium styracifolium, 80 parts of desmodium styracifolium, 40 parts of boxthorn fruit, 20 parts of immature bitter orange and 20 parts of common burreed rhizome.

The preparation method of the traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones in the embodiments 1 to 3 comprises the following steps:

s1, weighing 48-55 parts of purple gentian root, 202 parts of chicken' S gizzard-membrane 196-mangnolia-;

s2, weighing 9-12 parts of szechwan chinaberry fruit, adding 2-6 parts of salt, frying at 50-60 ℃ for 10-15min, and grinding into powder for later use;

s3, weighing 18-22 parts of starwort root, adding 4-5 parts of auxiliary material mature vinegar, placing in a closed container, stewing for 60min, then frying in a pan at 70-80 ℃ for 20min, taking out, drying in the air, grinding into powder for later use;

s4, adding the fructus Toosendan (S2) and radix Stellariae (S3) into the liquid medicine (S1), and mixing.

Examples 1-3 all provide the Chinese medicinal composition for treating gallstones, kidney stones, bladder stones, and since the treatment effects of the Chinese medicinal composition for treating gallstones, kidney stones, bladder stones provided in examples 1-3 are substantially parallel, the effects of the present invention will be described below by using only the Chinese medicinal composition prepared in example 3 as an example.

Application examples

The treatment method of the invention comprises the following steps: the decoction is taken once a day, and 7 days for long-term treatment are a treatment course.

The statistics of the cases of the present invention are as follows:

TABLE 129 treatment of patients with gallstones

TABLE 236 cases of renal calculus patients

TABLE 324 cases of vesical calculus patients

It should be noted that when the following claims refer to numerical ranges, it should be understood that both ends of each numerical range and any numerical value between the two ends can be selected, and the preferred embodiments of the present invention are described for the purpose of avoiding redundancy.

While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is intended to include such modifications and variations.

Claims (4)

1. A traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones is characterized by comprising the following raw material medicines in parts by weight: 48-55 parts of purple gentian root, 202 parts of chicken's gizzard-membrane 196, 18-22 parts of elecampane, 30-32 parts of green tangerine peel, 9-12 parts of szechwan chinaberry fruit, 38-42 parts of turmeric root-tuber, 18-22 parts of raw hawthorn fruit, 18-22 parts of starwort root, 38-42 parts of desmodium styracifolium, 78-84 parts of desmodium styracifolium, 38-43 parts of medlar, 19-20 parts of immature bitter orange and 20-22 parts of rhizoma sparganii.

2. The traditional Chinese medicine composition for treating gallstones, kidney stones and bladder stones, according to claim 1, is prepared from the following raw material medicines in parts by weight: 50 parts of purple gentian root, 200 parts of endothelium corneum gigeriae galli, 20 parts of costustoot, 30 parts of green tangerine peel, 10 parts of szechwan chinaberry fruit, 40 parts of turmeric root-tuber, 20 parts of raw hawthorn, 20 parts of starwort root, 40 parts of desmodium styracifolium, 80 parts of desmodium styracifolium, 40 parts of medlar, 20 parts of immature bitter orange and 20 parts of rhizoma sparganii.

3. The method for preparing a Chinese medicinal composition for treating gallstones, kidney stones and bladder stones of claim 1, comprising the steps of:

s1, weighing 48-55 parts of purple gentian root, 202 parts of chicken' S gizzard-membrane 196-containing materials, 18-22 parts of elecampane, 30-32 parts of green tangerine peel, 38-42 parts of radix curcumae, 18-22 parts of raw hawthorn, 38-42 parts of desmodium styracifolium, 78-84 parts of desmodium styracifolium, 38-43 parts of medlar, 19-20 parts of immature bitter orange and 20-22 parts of rhizoma sparganii, putting the raw materials into a marmite, adding water for decoction for 30-45min, removing medicine residues, and reserving medicine liquid for later use;

s2, weighing 9-12 parts of szechwan chinaberry fruit, adding 2-6 parts of salt, frying at 50-60 ℃ for 10-15min, and grinding into powder for later use;

s3, weighing 18-22 parts of starwort root, adding 4-5 parts of auxiliary material mature vinegar, placing in a closed container, moistening for 60min, frying in a pan at 70-80 deg.C for 20min, taking out, air drying, and grinding into powder;

s4, adding the fructus Toosendan (S2) and radix Stellariae (S3) into the liquid medicine (S1), and mixing.

4. The method for preparing a Chinese medicinal composition for treating cholelithiasis, renal calculus and vesical calculus as claimed in claim 3, wherein the amount of water added is 800-1400 parts by weight.