CN104888009A - Medicine for treating infantile eczema and preparation method of medicine - Google Patents

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medicine for treating infantile eczema and a preparation method of the medicine. The medicine is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 11-19 parts of prunella vulgaris, 6-14 parts of folium mori, 11-19 parts of senecio scandens, 11-19 parts of eragrostis cilianensis, 11-19 parts of polygonum aviculare, 11-19 parts of rhizoma cimicifugae, 11-19 parts of tobacco, 6-14 parts of common ducksmeat herb, 6-14 parts of cnidium monnieri, 6-14 parts of phellodendron amurense, 11-19 parts of glechoma longituba, 15-25 parts of the root of red-rooted salvia, 11-19 parts of radix paeoniae rubra, 3-9 parts of mirabilite, 20-40 parts of atractylodes macrocephala and 1-3 parts of menthol. The medicine is used for treating infantile eczema, and has the characteristics of being high in efficiency and cure rate and fewer in untoward effects.

Description

A kind of medicine for the treatment of infantile eczema and preparation method thereof

Technical field

The invention belongs to medical art, be specifically related to a kind of medicine for the treatment of infantile eczema and preparation method thereof.

Background technology

Infantile eczema is the common disease of department of pediatrics, is apt to occur in women's head-ornaments, ear, extremity and skinfold place, also can involves whole body.Its clinical characters is skin pruritus, and pleomorphism is damaged, and symmetry distribution, serosity oozes out, and easily develops into chronic eczema.Modern medicine thinks that primary disease is a kind of allergic skin disease, and mainly due to the allergy effect to food, color etc., again because the skin of baby is thinner, capillary network is abundant and endothelium is moisture and chloride is many, more responsive to various stimulating factor.Treatment there is no specific short, takes symptomatic treatment more, as oral Loratadine and external hormone medicine, though there is short term efficacy, there is side effect large, easy secondary infection, the shortcomings such as late result is undesirable.

Summary of the invention

In order to solve above-mentioned technical problem, the invention provides a kind of medicine for the treatment of infantile eczema and preparation method thereof.This medicine is used for the treatment of infantile eczema, has effective percentage high, and cure rate is high, the feature that untoward reaction is few.

The present invention is realized by following technical scheme:

Treat a medicine for infantile eczema, be made up of the raw material of Chinese medicine medicine of following weight proportion:

Spica Prunellae 11-19 part, Folium Mori 6-14 part, Herba Senecionis Scandentis 11-19 part, eragrostis cilianensisLink 11-19 part, Herba Polygoni Avicularis 11-19 part, Rhizoma Cimicifugae 11-19 part, Nicotiana tabacum L. 11-19 part, Herba Spirodelae 6-14 part, Fructus Cnidii 6-14 part, Cortex Phellodendri 6-14 part, Herba Glechomae 11-19 part, Radix Salviae Miltiorrhizae 15-25 part, Radix Paeoniae Rubra 11-19 part, Natrii Sulfas 3-9 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Mentholum 1-3 part.

Preferably, the medicine of above-mentioned treatment infantile eczema, be made up of the raw material of Chinese medicine medicine of following weight proportion:

Spica Prunellae 13-17 part, Folium Mori 8-12 part, Herba Senecionis Scandentis 13-17 part, eragrostis cilianensisLink 13-17 part, Herba Polygoni Avicularis 13-17 part, Rhizoma Cimicifugae 13-17 part, Nicotiana tabacum L. 13-17 part, Herba Spirodelae 8-12 part, Fructus Cnidii 8-12 part, Cortex Phellodendri 8-12 part, Herba Glechomae 13-17 part, Radix Salviae Miltiorrhizae 18-22 part, Radix Paeoniae Rubra 13-17 part, Natrii Sulfas 4-8 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Mentholum 1.5-2.5 part.

Preferred, the medicine of above-mentioned treatment infantile eczema, be made up of the raw material of Chinese medicine medicine of following weight proportion:

Spica Prunellae 15 parts, 10 parts, Folium Mori, Herba Senecionis Scandentis 15 parts, eragrostis cilianensisLink 15 parts, Herba Polygoni Avicularis 15 parts, Rhizoma Cimicifugae 15 parts, 15 parts, Nicotiana tabacum L., 10 parts, Herba Spirodelae, Fructus Cnidii 10 parts, Cortex Phellodendri 10 parts, Herba Glechomae 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Paeoniae Rubra 15 parts, 6 parts, Natrii Sulfas, the Rhizoma Atractylodis Macrocephalae 30 parts, Mentholum 2 parts.

The preparation method of the medicine of above-mentioned treatment infantile eczema, comprises the steps:

A () is according to part by weight weighting raw materials;

B () Mentholum is ground into fine powder, sieve for subsequent use;

C other each raw material of Chinese medicine medicine is decocted with water 2 times by (), first time adds drug weight 7-9 times of water gaging, decocts 1.5-2.5 hour, and second time adds the water of drug weight 5-7 times amount, decocts 1-2 hour; Collecting decoction, filter, filtrate 60 DEG C is concentrated into the clear paste that density is 1.08-1.12, is added on D101 macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, and decompression recycling ethanol, to without alcohol taste, filters, obtains drug extract;

D the drug extract of () step (c) gained adds above-mentioned Mentholum fine powder, with adding with stirring; And adjust ph to 6.5 ~ 7.5, add water and be adjusted to 2000 parts, filter, sterilizing, to obtain final product.

Preferably, in the preparation method of the medicine of above-mentioned treatment infantile eczema, in described step (c), first time adds drug weight 8 times of water gagings, decocts 2 hours.

Preferably, in the preparation method of the medicine of above-mentioned treatment infantile eczema, in described step (c), second time adds drug weight 6 times of water gagings, decocts 1.5 hours.

The preparation method of the medicine of above-mentioned treatment infantile eczema, detailed step is:

A () is according to part by weight weighting raw materials;

B () Mentholum is ground into fine powder, sieve for subsequent use;

C other each crude drug is decocted with water 2 times by (), first time adds drug weight 8 times of water gagings, decocts 2 hours, and second time adds the water of drug weight 6 times amount, decocts 1.5 hours; Collecting decoction, filter, filtrate 60 DEG C is concentrated into the clear paste that density is 1.08-1.12, is added on D101 macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, and decompression recycling ethanol, to without alcohol taste, filters, obtains drug extract;

D the drug extract of () step (c) gained adds above-mentioned Mentholum fine powder, with adding with stirring; And adjust ph to 6.5 ~ 7.5, add water and be adjusted to 2000 parts, filter, sterilizing, to obtain final product.

In the raw material of Chinese medicine medicine of the medicine for the treatment of infantile eczema of the present invention,

Herba Senecionis Scandentis has another name called Herba Hieracii Umbellati, Herba Senecionis Scandentis, Herba Sidae Rhombifoliae, Kowloon light, nine ridge light, is that it is cold in nature for the dry herb of feverfew Herba Senecionis Scandentis Senecio scandens Buch.-Ham.ex D.Don, the effects such as bitter in the mouth, has heat-clearing and toxic substances removing, improving eyesight, antipruritic.Heat-clearing and toxic substances removing; Improving acuity of vision and removing nebula; Killing parasites for relieving itching.Main flow sense; Upper respiratory tract infection; Pneumonia; Acute tonsillitis; Rib adenitis; Acute enteritis; Bacillary dysentery; Icterohepatitis; Gallbladder exudative dermatitis is scorching; Acute urinary tract infection; Conjunctival congestion and swelling pain cataracta; Carbuncle furuncle poison; Erysipelas; Eczema; Dry exudative dermatitis skin ulcer; Trichomonal vaginitis; Burn and scald.

Eragrostis cilianensisLink is the herb of grass eragrostis cilianensisLink.Latin name: Eragrostis cilianensis(All.) Link ex Vignolo-Lutati.Hardship, cold, enter heart channel.Heat-clearing and toxic substances removing, controls impetigo.

Nicotiana tabacum L. is the herb of Solanaceae Nicotiana plant Nicotiana tabacum L. Nicotiana tabacum L..Pungent, temperature.Poisonous.There is subduing swelling and detoxicating, effect of parasite killing.For furuncle swelling toxin, tinea capitis, tinea alba, tinea alba, venom.

Herba Spirodelae is the herb of plant and of its applications duckweed spirodela or blue or green duckweed Commom Duckweed, is used as medicine with whole herb with root, cold in nature, acrid in the mouth, and function diaphoresis rash, clearing away heat and promoting diuresis cure mainly the diseases such as pathogenic factor in the exterior heating, measles, edema.

Herba Glechomae is the dry aerial parts of Labiatae herbaceos perennial HUOXUEDAN (Glechomalongituba (Nakai) Kupr.), has another name called Herba Lysimachiae, HUOXUEDAN, Radix seu Folium Gaultheriae Forrestii.Acrid in the mouth, micro-hardship, cold nature, enters liver, kidney, urinary bladder channel.Merit is had a monopoly wet treating stranguria, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Be applicable to pyretic stranguria, stranguria caused by urinary stone, jaundice due to damp-heat, sore, carbuncle and painful swelling, traumatic injury.

Other Spica Prunellaes, Folium Mori, Herba Polygoni Avicularis, Fructus Cnidii, Cortex Phellodendri, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Natrii Sulfas, the Rhizoma Atractylodis Macrocephalae, Mentholum are all documented in Chinese Pharmacopoeia 2010 editions.

In the prescription of the medicine for the treatment of infantile eczema of the present invention, the refrigerant wind-dispelling heat-dissipating of Spica Prunellae, Folium Mori, Mentholum, Herba Senecionis Scandentis, eragrostis cilianensisLink, Herba Polygoni Avicularis, Nicotiana tabacum L., Herba Spirodelae, Fructus Cnidii, Cortex Phellodendri, Herba Glechomae, Natrii Sulfas heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra removing heat from blood and promoting blood circulation detoxify; Rhizoma Cimicifugae is pungent distributes table, as making medicine, can promote dispersing of pathogenic heat, alleviating pruritus, Rhizoma Atractylodis Macrocephalae dampness QI invigorating, but minimizing serosity oozes out, and promotes that health is for the absorption of non-ulceration serosity, accelerates the elimination of eczema.All medicines share, and play effect of heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, reducing swelling and alleviating pain altogether.Be used for the treatment of infantile eczema, have effective percentage high, cure rate is high, the feature that untoward reaction is few.

Beneficial effect of the present invention is: clinical test results shows, the medicine for the treatment of infantile eczema of the present invention, 1 the course for the treatment of obvious effective rate up to 51.25%, and matched group cure rate only has 18.75%, and both have pole significant difference (p < 0.01); 1 the course for the treatment of total effective rate up to 93.75%, and matched group effective percentage only has 57.5%, and both have pole significant difference (p < 0.01).

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Prescription:

Spica Prunellae 15g, Folium Mori 10g, Herba Senecionis Scandentis 15g, eragrostis cilianensisLink 15g, Herba Polygoni Avicularis 15g, Rhizoma Cimicifugae 15g, Nicotiana tabacum L. 15g, Herba Spirodelae 10g, Fructus Cnidii 10g, Cortex Phellodendri 10g, Herba Glechomae 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Natrii Sulfas 6g, Rhizoma Atractylodis Macrocephalae 30g, Mentholum 2g.

Preparation method

A () is according to part by weight weighting raw materials;

B () Mentholum is ground into fine powder, sieve for subsequent use;

C other each crude drug is decocted with water 2 times by (), first time adds drug weight 8 times of water gagings, decocts 2 hours, and second time adds the water of drug weight 6 times amount, decocts 1.5 hours; Collecting decoction, filter, filtrate 60 DEG C is concentrated into the clear paste that density is 1.08-1.12, is added on D101 macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, and decompression recycling ethanol, to without alcohol taste, filters, obtains drug extract;

D the drug extract of () step (c) gained adds above-mentioned Mentholum fine powder, with adding with stirring; And adjust ph to 6.5 ~ 7.5, add water and be adjusted to 2000ml, filter, sterilizing, to obtain final product.

Embodiment 2

Prescription

Spica Prunellae 13g, Folium Mori 12g, Herba Senecionis Scandentis 13g, eragrostis cilianensisLink 17g, Herba Polygoni Avicularis 13g, Rhizoma Cimicifugae 17g, Nicotiana tabacum L. 13g, Herba Spirodelae 12g, Fructus Cnidii 8g, Cortex Phellodendri 12g, Herba Glechomae 13g, Radix Salviae Miltiorrhizae 22g, Radix Paeoniae Rubra 17g, Natrii Sulfas 4g, Rhizoma Atractylodis Macrocephalae 35g, Mentholum 1.5g.

Preparation method

A () is according to part by weight weighting raw materials;

B () Mentholum is ground into fine powder, sieve for subsequent use;

C other each crude drug is decocted with water 2 times by (), first time adds drug weight 7 times of water gagings, decocts 1.5 hours, and second time adds the water of drug weight 5 times amount, decocts 1 hour; Collecting decoction, filter, filtrate 60 DEG C is concentrated into the clear paste that density is 1.08-1.12, is added on D101 macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, and decompression recycling ethanol, to without alcohol taste, filters, obtains drug extract;

D the drug extract of () step (c) gained adds above-mentioned Mentholum fine powder, with adding with stirring; And adjust ph to 6.5 ~ 7.5, add water and be adjusted to 2000ml, filter, sterilizing, to obtain final product.

Embodiment 3

Prescription

Spica Prunellae 17g, Folium Mori 8g, Herba Senecionis Scandentis 17g, eragrostis cilianensisLink 13g, Herba Polygoni Avicularis 17g, Rhizoma Cimicifugae 13g, Nicotiana tabacum L. 17g, Herba Spirodelae 8g, Fructus Cnidii 12g, Cortex Phellodendri 8g, Herba Glechomae 17g, Radix Salviae Miltiorrhizae 18g, Radix Paeoniae Rubra 13g, Natrii Sulfas 8g, Rhizoma Atractylodis Macrocephalae 25g, Mentholum 2.5g.

Preparation method

A () is according to part by weight weighting raw materials;

B () Mentholum is ground into fine powder, sieve for subsequent use;

C other each crude drug is decocted with water 2 times by (), first time adds drug weight 9 times of water gagings, decocts 2.5 hours, and second time adds the water of drug weight 7 times amount, decocts 2 hours; Collecting decoction, filter, filtrate 60 DEG C is concentrated into the clear paste that density is 1.08-1.12, is added on D101 macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, and decompression recycling ethanol, to without alcohol taste, filters, obtains drug extract;

D the drug extract of () step (c) gained adds above-mentioned Mentholum fine powder, with adding with stirring; And adjust ph to 6.5 ~ 7.5, add water and be adjusted to 2000ml, filter, sterilizing, to obtain final product.

Embodiment 4

Prescription

Spica Prunellae 11g, Folium Mori 6g, Herba Senecionis Scandentis 19g, eragrostis cilianensisLink 11g, Herba Polygoni Avicularis 19g, Rhizoma Cimicifugae 11g, Nicotiana tabacum L. 19g, Herba Spirodelae 14g, Fructus Cnidii 6g, Cortex Phellodendri 14g, Herba Glechomae 11g, Radix Salviae Miltiorrhizae 25g, Radix Paeoniae Rubra 19g, Natrii Sulfas 3g, Rhizoma Atractylodis Macrocephalae 40g, Mentholum 3g.

Preparation method is with embodiment 1.

Embodiment 5

Prescription

Spica Prunellae 19g, Folium Mori 14g, Herba Senecionis Scandentis 11g, eragrostis cilianensisLink 19g, Herba Polygoni Avicularis 11g, Rhizoma Cimicifugae 19g, Nicotiana tabacum L. 11g, Herba Spirodelae 6g, Fructus Cnidii 14g, Cortex Phellodendri 6g, Herba Glechomae 19g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 11g, Natrii Sulfas 9g, Rhizoma Atractylodis Macrocephalae 20g, Mentholum 1g.

Preparation method is with embodiment 1.

Carried out clinical trial to medicine prepared by embodiment 1, Details as Follows:

1. physical data

160 routine eczema infants, matched group 80 example, treatment group 80 example.200 routine eczema infants all meet eczema diagnostic criteria, betide any position of body surface, how symmetrical, and erythema occurs, and indefinite border, erythema mostly is intensive large pimple, papulovesicle, phlysis and sepage, or surface is with canescence bran shape squama etc.Wherein man 82 example, female 78 example; 11d to 4 year old age, average (2.0 ± 0.6) year; Course of disease 5d to 2 year; Head And Face 75 example, the whole body is dispersed in 39 examples, extremity 26 example.Get rid of in 1 week and accept glucocorticoid and Loratadine therapist; Skin lesion has erosion, oozes out and suppuration person; Treatments period prophylactic immunization person.

2 Therapeutic Method

Treatment group: adopt the Chinese medicinal lotion prepared of the embodiment of the present invention, (namely getting this product 100ml warm water to 500ml, mixing) is boiled temperature and is smoked and wash eczema position, each 15 minutes, every day 3 times.Attention: first should clean affected part by warm water before fumigation and wash method, and then first smoke with medicine juice and wash afterwards.Treat 7 days observe the curative effect, carry out therapeutic evaluation.

Matched group: put skin lesion on the skin outside Calamine Lotion, 3 times/d, treats 7 days observe the curative effect, carries out therapeutic evaluation.

Enjoin the food such as infant and wet nurse's fasting chicken, shrimp, fish, egg, beef, Carnis caprae seu ovis, Herba Alii fistulosi, Rhizoma Zingiberis Recens, Bulbus Allii, Eriocheir sinensis, Fructus Capsici, cannot allow children playing with sand, cold water, dust, soap bubble, detergent etc., stimulate with soap, hot water less, reduce bathtime and number of times, the roomy clothes of cotton is worn to infant, hormones external-applied ointment can not be used, in order to avoid cause corticosteroid dermatitis, be difficult to treatment.

3 observation index and efficacy determination

To the subjective symptoms of infant and sign by 4 grades of point systems the first visit same day and treat and carry out record in latter 7 days.Comprise pruritus, erythema, pimple, ooze out, erosion, squama, coarse, plump.0=is slight without, 1=, 2=moderate, 3=severe.Integration after therapeutic index (%)=(before treating integration) treatment) front integration × 100% of/treatment.Efficacy determination: recovery from illness: therapeutic index > 95%; Remarkable: therapeutic index 60%-95%; Effective: therapeutic index 20%-59%; Invalid: therapeutic index < 20%.The percent that recovery from illness adds effective number of cases divides counts total effective rate.

4. therapeutic outcome

4. 1 liang of group therapeutic effect compares in table 1

Table 1 result shows, the medicine for the treatment of infantile eczema of the present invention, 1 the course for the treatment of obvious effective rate up to 51.25%, and matched group cure rate only has 18.75%, and both have pole significant difference (p < 0.01); 1 the course for the treatment of total effective rate up to 93.75%, and matched group effective percentage only has 57.5%, and both have pole significant difference (p < 0.01).

A table 1 liang group therapeutic effect compares

Group	Number of cases	Recovery from illness	Significantly	Effectively	Invalid	Cure rate (%)	Total effective rate (%)
								Treatment group	80	41	18	16	5	51.25*	93.75*
Matched group	80	15	15	22	34	18.75	57.5

Note: compare matched group, P<0.01, difference has statistical significance

4. 2 untoward reaction

In the routine infant of treatments period 160 there is untoward reaction in none example.22 example recovery from illness infants because crossing ichthyophagy, shrimp, Eriocheir sinensis allergy sufferers 3 example, were all cured after 5 months to 1 year.Invalid 5 examples for the treatment of group are non-diet raw meat, peppery food, belong to and mismatch therapist, take a favorable turn after diet raw meat, peppery product.

Claims (7)

1. treat a medicine for infantile eczema, it is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight proportion:

Spica Prunellae 11-19 part, Folium Mori 6-14 part, Herba Senecionis Scandentis 11-19 part, eragrostis cilianensisLink 11-19 part, Herba Polygoni Avicularis 11-19 part, Rhizoma Cimicifugae 11-19 part, Nicotiana tabacum L. 11-19 part, Herba Spirodelae 6-14 part, Fructus Cnidii 6-14 part, Cortex Phellodendri 6-14 part, Herba Glechomae 11-19 part, Radix Salviae Miltiorrhizae 15-25 part, Radix Paeoniae Rubra 11-19 part, Natrii Sulfas 3-9 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Mentholum 1-3 part.

2. the medicine for the treatment of infantile eczema according to claim 1, is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight proportion:

Spica Prunellae 13-17 part, Folium Mori 8-12 part, Herba Senecionis Scandentis 13-17 part, eragrostis cilianensisLink 13-17 part, Herba Polygoni Avicularis 13-17 part, Rhizoma Cimicifugae 13-17 part, Nicotiana tabacum L. 13-17 part, Herba Spirodelae 8-12 part, Fructus Cnidii 8-12 part, Cortex Phellodendri 8-12 part, Herba Glechomae 13-17 part, Radix Salviae Miltiorrhizae 18-22 part, Radix Paeoniae Rubra 13-17 part, Natrii Sulfas 4-8 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Mentholum 1.5-2.5 part.

3. the medicine for the treatment of treatment infantile eczema according to claim 2, is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight proportion:

Spica Prunellae 15 parts, 10 parts, Folium Mori, Herba Senecionis Scandentis 15 parts, eragrostis cilianensisLink 15 parts, Herba Polygoni Avicularis 15 parts, Rhizoma Cimicifugae 15 parts, 15 parts, Nicotiana tabacum L., 10 parts, Herba Spirodelae, Fructus Cnidii 10 parts, Cortex Phellodendri 10 parts, Herba Glechomae 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Paeoniae Rubra 15 parts, 6 parts, Natrii Sulfas, the Rhizoma Atractylodis Macrocephalae 30 parts, Mentholum 2 parts.

4. the preparation method of the medicine of claim 1 or the treatment infantile eczema described in 2 or 3, comprises the steps:

A () is according to part by weight weighting raw materials;

B () Mentholum is ground into fine powder, sieve for subsequent use;

C other each raw material of Chinese medicine medicine is decocted with water 2 times by (), first time adds drug weight 7-9 times of water gaging, decocts 1.5-2.5 hour, and second time adds the water of drug weight 5-7 times amount, decocts 1-2 hour; Collecting decoction, filter, filtrate 60 DEG C is concentrated into the clear paste that density is 1.08-1.12, is added on D101 macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, and decompression recycling ethanol, to without alcohol taste, filters, obtains drug extract;

D the drug extract of () step (c) gained adds above-mentioned Mentholum fine powder, with adding with stirring; And adjust ph to 6.5 ~ 7.5, add water and be adjusted to 2000 parts, filter, sterilizing, to obtain final product.

5. the preparation method of the medicine for the treatment of infantile eczema according to claim 4, is characterized in that, in described step (c), first time adds drug weight 8 times of water gagings, decocts 2 hours.

6. the preparation method of the medicine for the treatment of infantile eczema according to claim 4, is characterized in that, in described step (c), second time adds drug weight 6 times of water gagings, decocts 1.5 hours.

7. the preparation method of the medicine for the treatment of infantile eczema according to claim 4, is characterized in that, detailed step is:

A () is according to part by weight weighting raw materials;

B () Mentholum is ground into fine powder, sieve for subsequent use;

C other each crude drug is decocted with water 2 times by (), first time adds drug weight 8 times of water gagings, decocts 2 hours, and second time adds the water of drug weight 6 times amount, decocts 1.5 hours; Collecting decoction, filter, filtrate 60 DEG C is concentrated into the clear paste that density is 1.08-1.12, is added on D101 macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, and decompression recycling ethanol, to without alcohol taste, filters, obtains drug extract;

D the drug extract of () step (c) gained adds above-mentioned Mentholum fine powder, with adding with stirring; And adjust ph to 6.5 ~ 7.5, add water and be adjusted to 2000 parts, filter, sterilizing, to obtain final product.