CN104887856A - Oral administration medicine for treating Sheehan syndromes and preparation method thereof - Google Patents

Abstract

The invention provides an oral administration medicine for treating Sheehan syndromes and a preparation method thereof. The oral administration medicine comprises the following components in parts by mass: 1-3 parts of common curculigo rhizome and 1-3 parts of licorice. The preparation method of the medicine comprises the following steps: purchasing high-quality clean first-grade common curculigo rhizome and licorice according to the parts by mass, picking out residual impurities respectively, and then soaking in cold boiled water for half an hour for later use; and putting the soaked medicines and the supernatant liquid for soaking the medicines into a marmite together, injecting an appropriate amount of cold boiled water to decoct twice, namely performing decoction of the first time for 30 minutes and performing the decoction of the second time for 25 minutes by injecting slightly-warm boiled water after pouring out the liquid medicine obtained by the decoction of the first time, and finally, mixing and concentrating the liquid medicines obtained by the decoction of the two times into 800mL of a 50% traditional Chinese medicine solution.

Description

A kind of endo-medicine and preparation method for the treatment of Sheehan syndrome

Technical field

The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of endo-medicine for the treatment of Sheehan syndrome, particularly for the endo-medicine of mankind's Sheehan syndrome patient and the field of preparation method.

Background technology

Sheehan syndrome, it is a kind of syndrome found by seat Han Shi (Sheehan) before more than 100 years, massive hemorrhage is there is when puerperal, shock overlong time, just can cause the hypokinetic sequela of anterior pituitary, show as and become thin, weak, alopecia, fear of cold, amenorrhea, mastatrophy etc., severe patient can be lethal, be referred to as Sheehan syndrome clinically, its symptom is: a, there is protopathy Yin Kecha: as postpartum hemorrhage, pituitary tumor, hypophysis operation or radiotherapy, craniocerebral trauma, infect or inflammation (tuberculosis, prunus mume (sieb.) sieb.et zucc. poison, meningoencephalitis), systemic disease (leukemia, lymphoma, cerebral arteriosclerosis, malnutrition) and immunity hypophysitis etc., b, promoting sexual gland hormone and prolactin secretion are not enough disease group: puerperal agalactia, amenorrhea, the moon, axil, milphae, sparse (male's beard is rare), hyposexuality, disappearance, atrophy of external genitalia, uterus, mastatrophy (impotence, testis, atrophy of prostate), c, thyrotropin are not enough disease group: deficiency of QI with disinclination to talk, apathetic expression, the hypophrenia, slow movement, loss of appetite, fear of cold, hypohidrosis, xerosis cutis, facial edema due to deficiency be greenish yellow, even occur myxedema etc., d, thyroliberin are not enough disease group: dizzy, faint, Nausea and vomiting, stomachache, suffer from diarrhoea, lose weight, blood pressure drops, easy infection and faint, even suffer a shock, stupor etc., e, Hypophysis storm: if any various stress, infection, operation, wound, direct stimulation, digestive tract disease, some drugs (calm, anesthetis and antidiabetic drug etc.) all can make protopathy increase the weight of and bring out crisis to occur.

So, just how finding a kind of medicine effectively can treating Sheehan syndrome, is our current problem in urgent need to solve.

Summary of the invention

The object of this invention is to provide a kind of endo-medicine and preparation method for the treatment of Sheehan syndrome, to solve Sheehan syndrome patient restorative problem early.This medicine is that have advantages of perfect compatibility, the efficacy of a drug is powerful with common Chinese herbal medicine for raw material, and hit pathogenesis, fully demonstrated replenishing vital QI with drugs of warm nature kidney yang, the Therapeutic Principle of benefiting vital QI and blood.

For reaching the object of foregoing invention, the technical solution adopted in the present invention is: provide a kind of endo-medicine for the treatment of Sheehan syndrome, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Rhizoma Curculiginis 1-3 part;

Radix Glycyrrhizae 1-3 part.

According to the endo-medicine for the treatment of Sheehan syndrome provided by the present invention, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Rhizoma Curculiginis 1 part;

1 part, Radix Glycyrrhizae.

Treat endo-medicine and the preparation method of Sheehan syndrome, it is characterized in that, described method comprises the steps:

A, choose the clean one-level Rhizoma Curculiginis of high-quality 1 part, 1 part, Radix Glycyrrhizae, after picking residual impurity respectively, for subsequent use soak half an hour in cold boiled water after;

B, the clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject appropriate cold boiled water and decoct twice, first time decocts 30 minutes, after the taking liquid that inclines, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 800 milliliters of 50%.

Treat endo-medicine and the preparation method of Sheehan syndrome, it is characterized in that, described instructions of taking is: will decoct well-done herb liquid and divide and take for two days, sub-service sooner or later, dosage 200 milliliters/time, taking medicine before meal.To take medicine 100-130 agent, all diseases all except and heal.

Herb liquid provided by the present invention is oral traditional Chinese medicine composition, and it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Rhizoma Curculiginis, nature and flavor: pungent, warm, poisonous, have effect that cold-damp was strengthened, dispelled to the kidney warming sun, are used for the treatment of sexual impotence cold sperm, urinary incontinence, coldness and pain in the epigastrium, soreness of waist and knee joint, muscles and bones weakness, lower limb contracture, climacteric syndrome;

Radix Glycyrrhizae, nature and flavor: sweet, flat, there is effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, be used for the treatment of lack of appetite, weakness of the spleen and stomach, stomachache loose stool, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity and strong.

When taking, well-done herb liquid will be decocted and divide and take for two days, sub-service sooner or later, dosage 200 milliliters/time, taking medicine before meal.To take medicine 100-130 agent, all diseases all except and heal.This medicine is that have advantages of perfect compatibility, the efficacy of a drug is powerful with common Chinese herbal medicine for raw material, and hit pathogenesis, fully demonstrated replenishing vital QI with drugs of warm nature kidney yang, the Therapeutic Principle of benefiting vital QI and blood.

Detailed description of the invention

Below embodiments of the present invention are described in detail

Sheehan syndrome, it is a kind of syndrome found by seat Han Shi (Sheehan) before more than 100 years, massive hemorrhage is there is when puerperal, shock overlong time, just can cause the hypokinetic sequela of anterior pituitary, show as and become thin, weak, alopecia, fear of cold, amenorrhea, mastatrophy etc., severe patient can be lethal, be referred to as Sheehan syndrome clinically, its symptom is: a, there is protopathy Yin Kecha: as postpartum hemorrhage, pituitary tumor, hypophysis operation or radiotherapy, craniocerebral trauma, infect or inflammation (tuberculosis, prunus mume (sieb.) sieb.et zucc. poison, meningoencephalitis), systemic disease (leukemia, lymphoma, cerebral arteriosclerosis, malnutrition) and immunity hypophysitis etc., b, promoting sexual gland hormone and prolactin secretion are not enough disease group: puerperal agalactia, amenorrhea, the moon, axil, milphae, sparse (male's beard is rare), hyposexuality, disappearance, atrophy of external genitalia, uterus, mastatrophy (impotence, testis, atrophy of prostate), c, thyrotropin are not enough disease group: deficiency of QI with disinclination to talk, apathetic expression, the hypophrenia, slow movement, loss of appetite, fear of cold, hypohidrosis, xerosis cutis, facial edema due to deficiency be greenish yellow, even occur myxedema etc., d, thyroliberin are not enough disease group: dizzy, faint, Nausea and vomiting, stomachache, suffer from diarrhoea, lose weight, blood pressure drops, easy infection and fainting even is suffered a shock, stupor etc., e, Hypophysis storm: if any various stress, infection, operation, wound, direct stimulation, digestive tract disease, some drugs (calm, anesthetis and antidiabetic drug etc.) all can make protopathy increase the weight of and bring out crisis to occur.

The present invention is exactly treatment for above-mentioned Sheehan syndrome and a kind of Chinese herbal medicine formula proposed, and adopt herb liquid prepared by this formula, good drug efficacy, evident in efficacy, toxic and side effects is little, effectively can treat Sheehan syndrome.Below specific embodiment provided by the present invention is described in detail.

Embodiment 1:

Choose the clean one-level Rhizoma Curculiginis of high-quality 10 grams, 15 grams, Radix Glycyrrhizae, after picking residual impurity respectively, for subsequent use soak half an hour in cold boiled water after; The clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject appropriate cold boiled water and decoct twice, first time decocts 30 minutes, after the taking liquid that inclines, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 800 milliliters of 50%.When taking, well-done herb liquid will be decocted and divide and take for two days, sub-service sooner or later, dosage 200 milliliters/time, taking medicine before meal.To take medicine 100-130 agent, all diseases all except and heal.

Embodiment 2:

Choose the clean one-level Rhizoma Curculiginis of high-quality 11 grams, 17 grams, Radix Glycyrrhizae, after picking residual impurity respectively, for subsequent use soak half an hour in cold boiled water after; The clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject appropriate cold boiled water and decoct twice, first time decocts 30 minutes, after the taking liquid that inclines, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 800 milliliters of 50%.When taking, well-done herb liquid will be decocted and divide and take for two days, sub-service sooner or later, dosage 200 milliliters/time, taking medicine before meal.To take medicine 100-110 agent, all diseases all except and heal.

Embodiment 3:

Choose the clean one-level Rhizoma Curculiginis of high-quality 10 grams, 15 grams, Radix Glycyrrhizae, after picking residual impurity respectively, for subsequent use soak half an hour in cold boiled water after; The clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject appropriate cold boiled water and decoct twice, first time decocts 30 minutes, after the taking liquid that inclines, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 800 milliliters of 50%.When taking, well-done herb liquid will be decocted and divide and take for two days, sub-service sooner or later, dosage 200 milliliters/time, taking medicine before meal.To take medicine 100-120 agent, all diseases all except and heal.

The present invention is through the treatment to nearly one hundred routine patient, and therapeutic effect is remarkable, and toxic and side effects is little, and part allusion quotation shape case is as follows.

1, patient: clock XX, female, 34 years old, address: Sichuan Province's Deyang City

Illness symptom: patient to give a birth triplet in medical first six months, massive hemorrhage during product, once twice bruise.Namely feel dizzy one week puerperal, fear of cold, loss of appetite, takes a step weak, hypogalactia, nausea and vomiting, and continue rear udder attachment atrophy, and milk lacks, and hair easily comes off.Through two months, above-mentioned all diseases were increased the weight of, and all day on curling oneself up bed, hyposexuality, menstruation apolipsis, is then shown in that in the course of disease armpit hair and pubes come off, invalid and come to seek medical advice through local clinics.Patient is previously healthy, and without any special medical history, husband is healthy, and three children are also healthy.Menstruation half menophania in 16 years old, menstrual cycle is normal.Indagation finding: face is sallow simple and unadorned, in without for fear of cold state, becomes thin, deficiency of QI with disinclination to talk, exiguous human hair, color is withered and yellow not damp, xerosis cutis, mastatrophy, pale lips, pale tongue, tongue owes Tianjin less, and dry pharynx does not moisten, thready and weak pulse without strength, and hear sounds is low, between apical region of heart and II grade of systolic murmur.Body temperature 37.2 DEG C, blood pressure 90/50mmHg, abdomen is put down soft, and liver spleen does not touch, and armpit hair takes off entirely.Chest x-ray is had an X-rayed, and cardiopulmonary are normal.Hemogram checking: erythrocyte 2,800,000/mm3, hemoglobin 6 grams of %, leukocyte 4,000/mm3, neutral 50%.Stool checks: do not find parasitic ovum just.Routine urianlysis is normal.Liver function test is normal.The department of obstetrics and gynecology consultation of doctors checks: atrophy of vulva, and pubes rareness is withered, and vagina is unobstructed, rare secretions, and uterus reduces, position after the body of palace, without tenderness, and adnexa ().Clinical diagnosis is " Sheehan syndrome ".This is QI and blood deficiency, kidney qi loss.Control when replenishing vital QI with drugs of warm nature kidney yang, benefiting vital QI and blood.

Treatment: more than throw top " herb liquid " and control it, every day potion, patient abides by and advises further consultation after 20 doses of taking medicine, and spirit takes a turn for the better, not fear of cold, and appetite increases, and take medicine to 60 doses, body is gradually rich, energetic, and hair has stopped coming off, and breast obviously increases, and libido is recovered.Hemogram is chemically examined: erythrocyte 3,200,000/mm3, hemoglobin 11 grams of %.Blood pressure 110/78mmHg.Take medicine again 20 doses, menstrual onset, amount is few, and color is at prime, and face has slight edema, and the Radix Glycyrrhizae medication in side is kept to 10g by this, continues again after 30 doses, and all diseases are all removed and heal.Drug withdrawal follows up a case by regular visits to 1 year, and menstruation is monthly risen, and physical recovery is as past.

2, patient: all XX, female, 36 years old, address: Chengdu, Sichuan Province

Illness symptom: readme: in medical the first eight wheat harvesting period childbirth second fetus, massive hemorrhage during childbirth, once repeatedly bruise.Namely feel dizzy five days puerperal, fear of cold, loss of appetite, takes a step weak, hypogalactia, nausea and vomiting, and continue rear udder attachment atrophy, and milk lacks, alopecia.Time spend a 15th day of a month, all diseases are increased the weight of, and curling oneself up is at bed all day, and libido obviously goes down, menstruation apolipsis, and in the course of disease, visible armpit hair and pubes come off, invalid and come to seek medical advice through certain town commune hospital diagnosis and treatment.Patient is previously healthy, and without special medical history, husband is healthy, and two children are also healthy.Menstruation 15 tide the beginning of the year, the eumenorrhea.Indagation finding: face is sallow simple and unadorned, in without for fear of cold state, becomes thin, deficiency of QI with disinclination to talk, exiguous human hair, color is withered and yellow not damp, xerosis cutis, mastatrophy, pale lips, pale tongue, tongue owes Tianjin less, and dry pharynx does not moisten, thready and weak pulse without strength, and hear sounds is low, between apical region of heart and II grade of systolic murmur.Body temperature 37.5 DEG C, blood pressure 90/50mmHg, abdomen is put down soft, and liver spleen does not touch, and armpit hair takes off entirely.Chest x-ray is had an X-rayed, and cardiopulmonary are normal.Hemogram checking: erythrocyte 2,800,000/mm3, hemoglobin 6 grams of %, leukocyte 4,000/mm3, neutral 50%.Stool checks: do not find parasitic ovum just.Routine urianlysis is normal.Liver function test is normal.The department of obstetrics and gynecology consultation of doctors checks: atrophy of vulva, and pubes rareness is withered, and vagina is unobstructed, rare secretions, and uterus reduces, position after the body of palace, without tenderness, and adnexa ().Clinical diagnosis is: Sheehan syndrome.

Treatment: more than throw top " herb liquid " and control it, every day potion, further consultation after 25 doses of taking medicine, spirit takes a turn for the better, not fear of cold, and food of receiving increases, and take medicine to 65 doses, body is gradually rich, energetic, and hair has stopped coming off, and breast increases, and libido is recovered.Hemogram is chemically examined: erythrocyte 3,200,000/mm3, hemoglobin 11 grams of %.Blood pressure 110/78mmHg.Take medicine again 18 doses, menstrual onset, amount is few, and color is at prime, and face has slight edema, and the Radix Glycyrrhizae medication in side is kept to 10g by this, continues again after 32 doses, and disease is removed and heals.Drug withdrawal follows up a case by regular visits to 3 year, and menstruation is monthly risen, physical recovery.

Claims (3)

1. treat an endo-medicine for Sheehan syndrome, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Rhizoma Curculiginis 1-3 part;

Radix Glycyrrhizae 1-3 part.

2. the endo-medicine for the treatment of Sheehan syndrome according to claim 1, is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Rhizoma Curculiginis 1 part;

1 part, Radix Glycyrrhizae.

3. the endo-medicine of the treatment Sheehan syndrome described in claim 1 or 2 and a preparation method, is characterized in that, described method comprises the steps:

A, according to mass parts than choosing the clean one-level Rhizoma Curculiginis of high-quality, Radix Glycyrrhizae, after picking residual impurity respectively, for subsequent use soak half an hour in cold boiled water after;

B, the clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject appropriate cold boiled water and decoct twice, first time decocts 30 minutes, after the taking liquid that inclines, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 800 milliliters of 50%.