CN101274043A - Chinese medicinal composite for curing Sheehans syndrome and method of preparing the same - Google Patents

Abstract

The invention relates to a traditional Chinese medicine combination which treats Sheehan's syndrome. The traditional Chinese medicine combination is made from radix codonopsis, liquorice, radix morindae officinalis, Indian bread, prepared daughter root of common monkshood, roots of Chinese angelica, semen cuscutae, chuanxiong rhizoma, wolfberry fruit, radix rehmanniae, largehead atractylodes rhizome, arillus longan, root of red rooted salvia, Chinese taxillus herb, glossy privet fruit, Chinese magnolivine fruit, rhizoma alismatis and/or acceptable supporting medium in pharmacy. The invention also relates to a preparation method of the traditional Chinese medicine combination. The traditional Chinese medicine combination has the functions of warming spleen-kidney, relieving the depressed liver, replenishing vital energy and nourishing blood, etc. and is applied to treating emaciation, hypodynamia, alopecia, aversion to cold, amenorrhea and other symptoms caused by the Sheehan's syndrome.

Description

A kind of Chinese medicine composition for the treatment of Sheehan syndrome and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of Sheehan syndrome and preparation method thereof.

Background technology

Sheehan syndrome belongs to common anterior hypopituitarism.Massive hemorrhage took place when puerperal, and the shock overlong time just can cause the hypokinetic sequela of anterior pituitary, and showing as disappears urinates, weak, alopecia, and fear of cold, amenorrhea, mastatrophy etc., severe patient can cause death.Be referred to as Sheehan syndrome clinically.

Anterior lobe of hypophysis is secreted a lot of trophic hormone, as promoting sexual gland hormone, and thyrotropin, thyroliberin, lactotropin, growth hormone etc.There is portal vein to get in touch between anterior pituitary and the hypothalamus, accepts the excretory nerve polypeptide material of hypothalamus.Postpartum hemorrhage causes these portal vein generation thrombosis easily, finally cause anterior lobe of hypophysis to necrose, various trophic hormone levels reduce greatly, so thyroid takes place, adrenal cortex, hypofunctions such as ovary, so the various symptoms that the front is said appear, and this is a kind of serious disease, importantly prevent postpartum hemorrhage, in case postpartum hemorrhage, just timely replenishment cycles blood volume is avoided the generation of suffering a shock.

This sick cardinal symptom has:

1. protopathy Yin Kecha is arranged: as postpartum hemorrhage, pituitary tumor, hypophysis operation or radiotherapy, craniocerebral trauma, infection or inflammation (tuberculosis, syphilis, meningoencephalitis), systemic disease (leukemia, lymphoma, cerebral arteriosclerosis, malnutrition) and immunity hypophysitis etc.

2. the not enough disease group of promoting sexual gland hormone and prolactin secretion: puerperal agalactia, amenorrhea, the moon, axil, milphae, sparse (male's beard rareness), hyposexuality, disappearance, atrophy of external genitalia, uterus, mastatrophy (impotence, testis, atrophy of prostate).

3. the not enough disease group of thyrotropin: deficiency of QI with disinclination to talk, apathetic expression, the hypophrenia, slow movement, loss of appetite, fear of cold, hypohidrosis, dry, the facial edema due to deficiency of the skin universe is greenish yellow even myxedema etc. occurs.

4. the not enough disease group of thyroliberin: dizzy, faint, feel sick, vomit, suffer from abdominal pain, suffer from diarrhoea, lose weight, blood pressure drops, easy infection and faint in addition suffer a shock, stupor etc.

5. hypophysis crisis; If any various stress, infection, operation, wound, direct stimulation, digestive tract disease, some drugs (calm, anesthetis and antidiabetic drug etc.) all can make protopathy increase the weight of and bring out crisis and take place.

Intrinsic is many because of the too hemorrhage hypophysis ischemic necrosis that causes of childbirth, due to the antepituitary endocrine function deficiency.Except that alternative medicine and symptomatic treatment, modern western medicine does not still have specific treatment at present, belongs to one of difficult treatment.

The traditional Chinese medical science thinks that Sheehan syndrome belongs to " puerperal blood faints ", " amenorrhea " reaches categories such as " asthenia ", the generation of primary disease can have multiple reason, but it is in the majority with postpartum hemorrhage, cause the time of blood deficiency in puerperal, even the card of the puerperal blood faints of collapsing, suffering a shock appears in the part patient, and this is a blood deficiency arteries and veins sky, excessive bleeding associated with exhaustion of QI so.Study carefully its sick internal organs that decrease, it is dirty to relate generally to spleen, liver, kidney three:

Suffering from a deficiency of the kidney, the kidney being the origin of congenital constitution, the main vessel used to hold grain at the imperial sacrifice of giving birth to.Jin is lost blood puerperal, excessive bleeding associated with exhaustion of QI, and the card of formation QI and blood deficiency undermines the kidney yin kidney yang then, then can cause primary disease.Had and modern many clinical and experimentatioies proved kidney yin kidney yang and hypothalamus already? the hypophysis target gland has very confidential relation.

Insufficiency of the spleen, spleen is a source of generating QI and blood, the foundation of acquired constitution.The modern furuncle metrorrhagia of producing, QI and blood deficiency undermines spleen soil, causes dysfunction of the spleen in transportation, and insufficiency of kidney-YANG, dysfunction of the spleen in warming, the spleen sun also declines, so but the cross-reference often of insufficiency of kidney-YANG and deficiency of spleen-YANG forms the card of deficiency of spleen-YANG and kidneyYANG.

Deficiency of the liver liver storing blood, and fork " woman is congenital with liver ".Massive blood loss can cause the deficiency of YIN-blood of kidney, and the kidney yin scarcity has influence on deficiency of liver-blood, so that the hepatic and renal YIN deficiency, and the disease of seeing infrequent menstruation, amenorrhea.

In a word, lose blood though primary disease starts from, disease is by blood and gas, and is both sick afterwards based on the deficiency of vital energy, has two the resembling of losing of QI and blood concurrently, and yang deficiency then shows as deficiency of spleen-YANG and kidneyYANG, and the deficiency of YIN then shows as the hepatic and renal YIN deficiency.Yet mistake is controlled for primary disease, or obstinate, and the card of qi depression to blood stasis can appear with the passing of time again in delay.

The traditional Chinese medical science should disease mainly be divided into four types:

1. yang deficiency of spleen and stomache: massive postpartum vaginal bleeding, milk is not secreted, amenorrhea, hyposexuality, coldness of the body and aversion to cold, Light-headedness, complexion HUANGBAI(sic), lethargy, spiritlessness and weakness, alopecia, inappetence, soreness of the waist and knees, the skin form is thin or the face limb is impractical, and pale tongue with thin fur is a little less than the deep-thready pulse.

2. QIXUELIANGXU type: massive postpartum vaginal bleeding, Light-headedness is very then fainted, and complexion is looked into the distance white simple and unadorned, and cold physique is breathed hard, moving then spontaneous perspiration, severe palpitation, the Na Gu amount is few, and it is sparse to turn to be yellow, and armpit hair, pubes come off, and skin is dried rough, amenorrhea.Body of the tongue is light red, white and thin fur, and arteries and veins carefully delays.

3. liver-kidney yin deficiency: dizzy tinnitus, dizzy desire is fallen forward, scaly dry skin, mastatrophy, hair is withered to come off, and it is fragrant that Na Gu owes, abdominal distention after the meal, amenorrhea, vaginal dryness, agitation is slept less, and spirit is gloomy, and body is skinny and wizened.Thin fur is few, red tongue, and arteries and veins comes thin string.

4. qi stagnation and blood stasis type: amenorrhea abdominal distention, the lower abdomen twinge, gastral cavity side of body distending pain, spirit depressing, irritated irritability, dizzy order flower, skin is done the first mistake, and that lays one's hand on is in the way, and hair is withered to fall.Body of the tongue is light red, doublely sees ecchymosis, and stringy and thready pulse is puckery.

The traditional Chinese medical science adopts this disease of decoction for the treatment of warming and recuperating the spleen and kidney, depressed liver-energy dispersing and QI regulating, benefiting QI and nourishing blood.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of Sheehan syndrome.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of Sheehan syndrome, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Radix Codonopsis 10-20 part Radix Glycyrrhizae 20-30 part Radix Morindae Officinalis 5-15 part

Poria 15-25 part Radix Aconiti Lateralis Preparata 15-20 part Radix Angelicae Sinensis 20-30 part

Semen Cuscutae 10-15 part Rhizoma Chuanxiong 5-10 part Fructus Lycii 20-30 part

Radix Rehmanniae 15-25 part Rhizoma Atractylodis Macrocephalae 10-20 part Arillus Longan 15-20 part

Radix Salviae Miltiorrhizae 15-25 part Herba Taxilli 10-15 part Fructus Ligustri Lucidi 10-20 part

Fructus Schisandrae Chinensis 20-25 part Rhizoma Alismatis 15-25 part

Effective ingredient is preferably made by weight by following raw materials according:

11 parts of 26 parts of Radix Morindae Officinaliss of 16 portions of Radix Glycyrrhizaes of Radix Codonopsis

26 parts of 18 parts of Radix Angelicae Sinensis of 21 parts of Radix Aconiti Lateralis Preparatas of Poria

26 parts of 8 parts of Fructus Lycii of 13 parts of Rhizoma Chuanxiongs of Semen Cuscutae

18 parts of 16 portions of Arillus Longans of 21 parts of Rhizoma Atractylodis Macrocephalaes of Radix Rehmanniae

16 parts of 13 parts of Fructus Ligustri Lucidi of 20 parts of Herba Taxillis of Radix Salviae Miltiorrhizae

21 parts of 23 portions of Rhizoma Alismatis of Fructus Schisandrae Chinensis

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) Radix Glycyrrhizae, Poria, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Radix Codonopsis, Radix Morindae Officinalis, Radix Aconiti Lateralis Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Lycii, Radix Rehmanniae, Arillus Longan, Radix Salviae Miltiorrhizae, Herba Taxilli, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Rhizoma Alismatis decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Chinese medicine composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Chinese medicine composition of the present invention has effects such as warming and recuperating the spleen and kidney, depressed liver-energy dispersing and QI regulating, benefiting QI and nourishing blood, be used for that Sheehan syndrome causes become thin, disease such as weak, alopecia, fear of cold, amenorrhea.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1: Chinese medicine composition granule of the present invention

(1) Radix Glycyrrhizae 260g, Poria 210g, Semen Cuscutae 130g, Rhizoma Atractylodis Macrocephalae 160g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Radix Codonopsis 160g, Radix Morindae Officinalis 110g, Radix Aconiti Lateralis Preparata 180g, Radix Angelicae Sinensis 260g, Rhizoma Chuanxiong 80g, Fructus Lycii 260g, Radix Rehmanniae 210g, Arillus Longan 180g, Radix Salviae Miltiorrhizae 200g, Herba Taxilli 130g, Fructus Ligustri Lucidi 160g, Fructus Schisandrae Chinensis 230g, Rhizoma Alismatis 210g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned clear paste, drying is ground into fine powder, adds lactose 400g, dextrin 600g, mixing sieves, with 75% ethanol wet granulation, drying, pack promptly.

Embodiment 2: Chinese medicine composition capsule of the present invention

(1) Radix Glycyrrhizae 260g, Poria 210g, Semen Cuscutae 130g, Rhizoma Atractylodis Macrocephalae 160g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Radix Codonopsis 160g, Radix Morindae Officinalis 110g, Radix Aconiti Lateralis Preparata 180g, Radix Angelicae Sinensis 260g, Rhizoma Chuanxiong 80g, Fructus Lycii 260g, Radix Rehmanniae 210g, Arillus Longan 180g, Radix Salviae Miltiorrhizae 200g, Herba Taxilli 130g, Fructus Ligustri Lucidi 160g, Fructus Schisandrae Chinensis 230g, Rhizoma Alismatis 210g add 8 times of decoctings and boil secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned clear paste, dry, be ground into fine powder, add dextrin 600g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: Chinese medicine composition tablet of the present invention

(1) Radix Glycyrrhizae 260g, Poria 210g, Semen Cuscutae 130g, Rhizoma Atractylodis Macrocephalae 160g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Radix Codonopsis 160g, Radix Morindae Officinalis 110g, Radix Aconiti Lateralis Preparata 180g, Radix Angelicae Sinensis 260g, Rhizoma Chuanxiong 80g, Fructus Lycii 260g, Radix Rehmanniae 210g, Arillus Longan 180g, Radix Salviae Miltiorrhizae 200g, Herba Taxilli 130g, Fructus Ligustri Lucidi 160g, Fructus Schisandrae Chinensis 230g, Rhizoma Alismatis 210g add 8 times of decoctings and boil secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, drying, be ground into fine powder, add starch 300g, microcrystalline Cellulose 20g is with 70% ethanol wet granulation, tabletting, coating are promptly.

Claims (4)

1, a kind of Chinese medicine composition for the treatment of Sheehan syndrome is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Radix Codonopsis 10-20 part Radix Glycyrrhizae 20-30 part Radix Morindae Officinalis 5-15 part

Poria 15-25 part Radix Aconiti Lateralis Preparata 15-20 part Radix Angelicae Sinensis 20-30 part

Semen Cuscutae 10-15 part Rhizoma Chuanxiong 5-10 part Fructus Lycii 20-30 part

Radix Rehmanniae 15-25 part Rhizoma Atractylodis Macrocephalae 10-20 part Arillus Longan 15-20 part

Radix Salviae Miltiorrhizae 15-25 part Herba Taxilli 10-15 part Fructus Ligustri Lucidi 10-20 part

Fructus Schisandrae Chinensis 20-25 part Rhizoma Alismatis 15-25 part

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

11 parts of 26 parts of Radix Morindae Officinaliss of 16 portions of Radix Glycyrrhizaes of Radix Codonopsis

26 parts of 18 parts of Radix Angelicae Sinensis of 21 parts of Radix Aconiti Lateralis Preparatas of Poria

26 parts of 8 parts of Fructus Lycii of 13 parts of Rhizoma Chuanxiongs of Semen Cuscutae

18 parts of 16 portions of Arillus Longans of 21 parts of Rhizoma Atractylodis Macrocephalaes of Radix Rehmanniae

16 parts of 13 parts of Fructus Ligustri Lucidi of 20 parts of Herba Taxillis of Radix Salviae Miltiorrhizae

21 parts of 23 portions of Rhizoma Alismatis of Fructus Schisandrae Chinensis

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) Radix Glycyrrhizae, Poria, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Radix Codonopsis, Radix Morindae Officinalis, Radix Aconiti Lateralis Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Lycii, Radix Rehmanniae, Arillus Longan, Radix Salviae Miltiorrhizae, Herba Taxilli, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Rhizoma Alismatis decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.