CN104887778A - Medicine for treating hyperostosis and preparation method of medicine - Google Patents

Abstract

The invention discloses a medicine for treating hyperostosis and a preparation method of the medicine. The medicine is mainly prepared from clematis roots, pawpaw, kusnezoff monkshood roots and suberect spatholobus stems in a certain weight proportion. The medicine has the functions of promotion of blood circulation, tendon relaxation, detumescence and pain relief, takes effect quickly when used for treating hyperostosis, has a good curative effect and does not have toxic or side effects.

Description

A kind of medicine for the treatment of hyperosteogeny and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of hyperosteogeny and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Medically, hyperosteogeny refers to due to degeneration of joint, so that the chronic joint disease that articular cartilage is destroyed and causes.Also known as osteoarthritis, osteoarthritis and hypertrophiarthritis etc.Clinical manifestation is arthralgia, and stiff and dysfunction, be commonly referred to be non-inflammation arthrosis, in fact prolonged illness joint also can occur synovitis.At present, because Western medicine effectively cannot treat hyperosteogeny, therefore there is great demand to the Chinese medicine of effectively treating hyperosteogeny in people, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally successfully have found the medicine of effectively treatment hyperosteogeny, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment hyperosteogeny.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Radix Clematidis, Fructus Chaenomelis, Radix Aconiti Kusnezoffii, Caulis Spatholobi, Herba Asari, the Radix Paeoniae Alba, Flos Rhododendri Mollis, Borneolum Syntheticum, Camphora to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat cervical vertebra, lumbar vertebra, hyperosteogeny and Osteoarthritis in aged pain.Wherein, select Radix Clematidis to be because its nature and flavor are pungent salty, temperature, poisonous, enter urinary bladder channel, have wind-damp dispelling, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump, controls gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Fructus Chaenomelis is selected to be that temperature, enters liver, spleen channel, have suppressing the hyperactive liver and easing the stomach, the function of the relaxing muscles and tendons that dries, and controls convulsion of vomiting and diarrhoea, arthralgia chiefly caused by damp pathogen, beriberi, edema, dysentery because its nature and flavor acid; Select Radix Aconiti Kusnezoffii to be because its nature and flavor are hot poisonous, search wind prevailing over dampness, dispersing cold for relieving pain, open the function of expectorant detumescence, control anemofrigid-damp arthralgia, broken wound is negative, wind syndrome of head, coldness and pain in the epigastrium, air parcel, cold-dysentery, sore throat, carbuncle, furuncle, scrofula.Select Caulis Spatholobi to be because its property bitter but sweet flavor, temperature, enters the heart, spleen two warp, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Herba Asari to be that temperature, enters lung, kidney channel, dispel the wind, cold expelling, row water because its nature and flavor are pungent, open the function of stealing, control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Flos Rhododendri Mollis is selected to be because its nature and flavor are pungent, temperature, poisonous, there is expelling wind and removing dampness, the function of dissipating blood stasis analgesic therapy, for rheumatism, numbness carbuncle, traumatic injury.Borneolum Syntheticum is selected to be because its nature and flavor are worked hard, cool, enter the heart, lung meridian, have logical all keys, loose stagnated fire, removing nebula improving eyesight, the function of reducing swelling and alleviating pain, controls apoplexy locked mouth, calentura coma ， Jing Epilepsy expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, conjunctivitis, enterobiasis.Select Camphora to be because its nature and flavor are hot, enter heart spleen two warp, have sensible, parasite killing, pain relieving, ward off dirty function, control trusted subordinate's distending pain, beriberi, skin infection scabies, toothache, traumatic injury.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:

Radix Clematidis 90-110 gram, Fructus Chaenomelis 10-15 gram, Radix Aconiti Kusnezoffii 10-15 gram, Caulis Spatholobi 10-15 gram, Herba Asari 10-15 gram, Radix Paeoniae Alba 10-15 gram, Flos Rhododendri Mollis 10-15 gram, Borneolum Syntheticum 10-20 gram, Camphora 10-20 gram, 50% ethanol 1400 grams-1600 grams;

Be preferably:

Radix Clematidis 100 grams, Fructus Chaenomelis 12 grams, Radix Aconiti Kusnezoffii 12 grams, Caulis Spatholobi 12 grams, Herba Asari 12 grams, the Radix Paeoniae Alba 12 grams, Flos Rhododendri Mollis 12 grams, Borneolum Syntheticum 15 grams, Camphora 15 grams, 50% ethanol 1500 grams.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1. Radix Clematidis: pick clean impurity, removes residual stem, is soaked in water, pull out and run through, cutting, dry;

2. Fructus Chaenomelis: clear water is cleaned, and slightly soaks, moistening, to thoroughly, is put in food steamer and is cooked, take advantage of fervent sheet, weather exposure, with by red turn atropurpureus till;

3. Radix Aconiti Kusnezoffii: autumn excavates, and removes residual stem and earth, cleans, and section, dries;

4. Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;

5. Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;

6. the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;

7. Flos Rhododendri Mollis: get crude drug, removing impurity, stalk and leaf, sieve dedust bits;

8. Borneolum Syntheticum: original is used as medicine;

9. Camphora: the 9-12 month cuts down veteran, get its tree root, trunk, branch, be split into fragment, put in distillator and distill, the Camphora contained in Lignum cinnamomi camphorae and volatile oil distillate with steam, namely rough Camphora is obtained after cooling, by rough Camphora again through sublimation purifying, obtain Gum Camphor powder, camphor powder is entered in model to squeeze, then become transparent camphor tablet, the used time smashes and grinds into powder.

Two, prepare

1. the Radix Clematidis of described weight, Fructus Chaenomelis, Radix Aconiti Kusnezoffii, Caulis Spatholobi, Herba Asari, the Radix Paeoniae Alba, Flos Rhododendri Mollis mixing are ground into coarser powder;

2. Borneolum Syntheticum, Camphora and the coarser powder that is ground into are put into container simultaneously, add ethanol sealing immersion 15 days and get final product.

Medicine of the present invention have invigorate blood circulation, relaxing muscles and tendons, detumescence, pain relieving function, treatment cervical vertebra, lumbar vertebra, hyperosteogeny and old osteoarthritis pain instant effect, good effect, has no side effect.

In prescription, Radix Clematidis has wind-damp dispelling, the meridian dredging, and the function of the loose hypochondriac lump is monarch drug; Fructus Chaenomelis suppressing the hyperactive liver and easing the stomach, dry relaxing muscles and tendons, and Caulis Spatholobi is invigorated blood circulation, relaxing muscles and tendons, controls arthralgia chiefly caused by damp pathogen, edema, paralysis and numbness, is ministerial drug; Three taste medicines jointly play invigorate blood circulation, relaxing muscles and tendons, detumescence, pain relieving effect, treatment hyperosteogeny effect is comprehensive, and is that master can be effected a permanent cure with relaxing muscles and tendons to promote blood circulation; Camphora has sensible, parasite killing, pain relieving, wards off dirty function, is adjuvant drug; Flos Rhododendri Mollis expelling wind and removing dampness, dissipating blood stasis analgesic therapy is for making medicine; All medicines take stopgap measures with being left, and said medicine combined, and makes it efficacy of drugs and produce synergism, thus effectively can treat the recurrence of hyperosteogeny.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get West Germany rabbit 10, male and female dual-purpose, body weight 2.0-2.5kg, pull out only by the rabbit abdominal part rabbit hair, by the liquid medicine painting rabbit abdominal part prepared, every day three times, be used in conjunction three days, rabbit food is normal, has no adverse reaction.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 30 examples for medical treatment

2, diagnostic criteria

Multiple at 20 ~ 50 years old.Articular surface skin is red heat.Affected joints pain, tenderness, for migrans, without joint function disturbance.Joint Early swelling is fusiformis, late period dysfunction and tetanic deformity.X-ray inspection local or whole body osteoporosis, interval pain, multi-joint is got involved.

3, Therapeutic Method

During treatment, embrocate in affected part with cotton balls dip in liquid medicine, or cotton balls is placed on the light tabletting in pain spot place and carves, to promote curative effect, every day 3-5 time 7 days is a course for the treatment of, continuously 5 courses for the treatment of of use.

4, efficacy assessment standard

Effective: hyperosteogeny symptom is eliminated, osteoarthrosis functional rehabilitation, recovery from illness.

Take a turn for the better: hyperosteogeny pain symptom alleviates, and osteoarthrosis function progressively takes a turn for the better.

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy hyperosteogeny patient 30 example of the present invention, effective 25 examples of result, obvious effective rate is 83.33%, and take a turn for the better 4 examples, and improvement rate is 13.34%, and invalid 1 example, total effective rate is 96.67%.

Claims (3)

1. treat the medicine of hyperosteogeny for one kind, it is characterized in that: it is made up of the crude drug in following weight range: Radix Clematidis 90-110 gram, Fructus Chaenomelis 10-15 gram, Radix Aconiti Kusnezoffii 10-15 gram, Caulis Spatholobi 10-15 gram, Herba Asari 10-15 gram, Radix Paeoniae Alba 10-15 gram, Flos Rhododendri Mollis 10-15 gram, Borneolum Syntheticum 10-20 gram, Camphora 10-20 gram, 50% ethanol 1400 grams-1600 grams.

2. medicine according to claim 1, wherein the consumption of each crude drug is: Radix Clematidis 100 grams, Fructus Chaenomelis 12 grams, Radix Aconiti Kusnezoffii 12 grams, Caulis Spatholobi 12 grams, Herba Asari 12 grams, the Radix Paeoniae Alba 12 grams, Flos Rhododendri Mollis 12 grams, Borneolum Syntheticum 15 grams, Camphora 15 grams, 50% ethanol 1500 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that:

One, get the raw materials ready

1. Radix Clematidis: pick clean impurity, removes residual stem, is soaked in water, pull out and run through, cutting, dry;

2. Fructus Chaenomelis: clear water is cleaned, and slightly soaks, moistening, to thoroughly, is put in food steamer and is cooked, take advantage of fervent sheet, weather exposure, with by red turn atropurpureus till;

3. Radix Aconiti Kusnezoffii: autumn excavates, and removes residual stem and earth, cleans, and section, dries;

4. Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;

5. Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;

6. the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;

7. Flos Rhododendri Mollis: get crude drug, removing impurity, stalk and leaf, sieve dedust bits;

8. Borneolum Syntheticum: original is used as medicine;

9. Camphora: the 9-12 month cuts down veteran, get its tree root, trunk, branch, be split into fragment, put in distillator and distill, the Camphora contained in Lignum cinnamomi camphorae and volatile oil distillate with steam, namely rough Camphora is obtained after cooling, by rough Camphora again through sublimation purifying, obtain Gum Camphor powder, camphor powder is entered in model to squeeze, then become transparent camphor tablet, the used time smashes and grinds into powder;

Two, prepare

1. the Radix Clematidis of described weight, Fructus Chaenomelis, Radix Aconiti Kusnezoffii, Caulis Spatholobi, Herba Asari, the Radix Paeoniae Alba, Flos Rhododendri Mollis mixing are ground into coarser powder;

2. Borneolum Syntheticum, Camphora and the coarser powder that is ground into are put into container simultaneously, add ethanol sealing immersion 15 days and get final product.