CN104887765A - Traditional Chinese medicine composition for treating nasosinusitis and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating nasosinusitis and preparation method and application thereof Download PDFInfo
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- CN104887765A CN104887765A CN201510314418.4A CN201510314418A CN104887765A CN 104887765 A CN104887765 A CN 104887765A CN 201510314418 A CN201510314418 A CN 201510314418A CN 104887765 A CN104887765 A CN 104887765A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating nasosinusitis and a preparation method and application thereof. The traditional Chinese medicine composition is at least prepared from adder tongue herb, persicaria capitata, radix gaultheriae and mallotus furetianus. The invention further provides the preparation method of the traditional Chinese medicine composition and the application of the traditional Chinese medicine composition in preparation of drugs for treating nasosinusitis. Compared with the prior art, the traditional Chinese medicine composition is simple in formula, low in preparation cost, is free of toxic and side effect, easily acceptable to patients, has a very obvious effect on treating nasosinusitis, and is high in efficiency and low in recurrence rate.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of sinusitis and its preparation method and application, belong to field of traditional Chinese.
Background technology
One or more nasal sinuses is inflamed and is called sinusitis, and the nasal sinuses involved comprises: maxillary sinus, sieve hole, sinus frontalis and sphenoid sinus, this is a kind of disease that sickness rate is higher in crowd, affects patients ' life quality.Sinusitis can be divided into acute, chronic sinusitis 2 kinds.Acute sinusitis is many to be caused by upper respiratory tract infection, and antibacterial and viral infection can be simultaneously concurrent.More acute person is common for chronic sinusitis, often gets involved for multiple nasal sinuses simultaneously.The infection of acute sinusitis often comes from: Dou Yuan sexuality dye, nasal cavity source sexuality dye, the sexy dye in adjacent tissue source, Hematogenous infection, wound source sexuality dye, also have systemic factor and poisoning factor to cause.The chronic sinusitis cause of disease for being changed by acute sinusitis, occlusive disease because, toxicity of pathogenic bacteria is strong, odontogenic infection, wound and foreign body, nasal sinuses anatomical factors or general factor.
At present, generally chemotherapy is adopted to the treatment of sinusitis, and great majority are antibiotic, although these medicine curative effects are rapid, often based on relief of symptoms, cure the symptoms, not the disease, and usually can with a series of side reaction, and higher relapse rate.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of sinusitis and its preparation method and application.
For foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of Chinese medicine composition for the treatment of sinusitis, it is at least made up of the raw material of following weight portion: Herba Ophioglossi 10 parts, Herba Polygoni Capitati 2-18 part, Caulis et folium gaultheriae yunnanensis 2-18 part, francolin tea 2-18 part.
As preferably, the Chinese medicine composition of described treatment sinusitis is at least made up of the raw material of following weight portion: Herba Ophioglossi 10 parts, Herba Polygoni Capitati 5-15 part, Caulis et folium gaultheriae yunnanensis 5-15 part, francolin tea 5-15 part.
Preferred as another kind, the Chinese medicine composition of described treatment sinusitis, is characterized in that, it is at least made up of the raw material of following weight portion: Herba Ophioglossi 10 parts, Herba Polygoni Capitati 10 parts, Caulis et folium gaultheriae yunnanensis 10 parts, francolin tea 10 parts.
Present invention also offers the preparation method of described treatment sinusitis Chinese medicine composition, mainly comprise the steps:
Take Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea, mixing, soaks, and decocts, to obtain final product;
Or mainly comprise the steps:
(1) Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea is taken;
(2) Caulis et folium gaultheriae yunnanensis extracts volatile oil, and volatile oil is for subsequent use; The mother solution extracted after volatile oil is for subsequent use; The Caulis et folium gaultheriae yunnanensis medicinal residues extracted after volatile oil are for subsequent use;
(3) the Caulis et folium gaultheriae yunnanensis medicinal residues after extracting volatile oil in Herba Ophioglossi, Herba Polygoni Capitati and francolin tea and step (2) mix, extracting in water, extracting solution and step (2) is middle extract volatile oil after mother solution merge, obtain total extracting solution; Total extracting solution and the middle volatile oil extracted of step (2) are with the use of the Chinese medicine composition as described treatment sinusitis.
As preferably, the preparation method of described treatment sinusitis Chinese medicine composition mainly comprises the steps:
Take Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea, mixing, add 8-12 times of water soaking 0.5-1.5h, decoct 1-3 time, each 1-2h, collecting decoction, to obtain final product;
Or mainly comprise the steps:
(1) Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea is taken;
(2) Caulis et folium gaultheriae yunnanensis extracts volatile oil, and volatile oil is for subsequent use; The mother solution extracted after volatile oil is for subsequent use; The Caulis et folium gaultheriae yunnanensis medicinal residues extracted after volatile oil are for subsequent use;
(3) the Caulis et folium gaultheriae yunnanensis medicinal residues after Herba Ophioglossi, Herba Polygoni Capitati and francolin tea extract volatile oil with step (2) is middle mix, add 8-14 times of volume water, boil and extract 1-3 time, each 1-3 hour, merge extractive liquid, mother solution after extracting volatile oil in extracting solution and step (2) merges, and obtains total extracting solution; Total extracting solution and the middle volatile oil extracted of step (2) are with the use of the Chinese medicine composition as described treatment sinusitis.
Preferred as another kind, described volatile oil with porous silica solidification or can use cyclodextrin inclusion compound.
The present invention finally additionally provides the application of described Chinese medicine composition in preparation treatment sinusitis medicine.
As preferably, by described Chinese medicine composition conveniently formulation method make oral formulations.
Preferred as another kind, described oral formulations is tablet, capsule, oral liquid, granule, powder, pill or drop pill
Above-mentioned Chinese medicine composition of the present invention adds required various customary adjuvant when preparing different dosage form, such as diluent, adhesive, disintegrating agent, fluidizer, lubricant, correctives, enclose material, adsorbing material etc. are prepared into the conventional oral formulations of any one with the formulation method of routine, such as, can be granule, powder, tablet, capsule, pill, oral liquid, drop pill etc.
The Chinese medicine composition principles of formulating prescriptions of the present invention are: Herba Ophioglossi is monarch drug in side, helps with Herba Polygoni Capitati, francolin tea and Caulis et folium gaultheriae yunnanensis, gathers heat-clearing and toxic substances removing altogether, expelling wind and removing dampness and the sensible merit of lung qi dispersing, effectively treatment sinusitis and prevent it from recurring.
Beneficial effect of the present invention is mainly:
Traditional Chinese medicine composition for treating sinusitis of the present invention has the effect of highly significant, and not only effective percentage is high, and relapse rate is low, has no side effect, and prescription is simple, and preparation cost is low, and patient is easy to accept.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should note scope of the present invention not by any restriction of these examples.
Embodiment 1
Prescription: Herba Ophioglossi 10g, Herba Polygoni Capitati 2g, Caulis et folium gaultheriae yunnanensis 2g, francolin tea 2g
Preparation method:
Above-mentioned medical material is added 8 times amount water soaking 0.5 hour, decoct 1 time, each 3 hours, collecting decoction, to obtain final product.
Usage and consumption: every day potion.
Embodiment 2
Prescription: Herba Ophioglossi 10g, Herba Polygoni Capitati 18g, Caulis et folium gaultheriae yunnanensis 18g, francolin tea 18g
Preparation method:
Above-mentioned medical material is added 12 times amount water soaking 1.5 hours, decoct 3 times, each 1 hour, collecting decoction, to obtain final product.
Usage and consumption: every day potion.
Embodiment 3
Prescription: Herba Ophioglossi 10g, Herba Polygoni Capitati 10g, Caulis et folium gaultheriae yunnanensis 10g, francolin tea 10g
Preparation method:
Above-mentioned medical material is added 10 times amount water soaking 1 hour, decoct 2 times, each 1.5 hours, collecting decoction, to obtain final product.
Usage and consumption: every day potion.
Embodiment 4
Prescription: Herba Ophioglossi 10g, Herba Polygoni Capitati 2g, Caulis et folium gaultheriae yunnanensis 2g, francolin tea 2g
Preparation method:
(1) Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea is taken;
(2) Caulis et folium gaultheriae yunnanensis extracts volatile oil, and volatile oil is for subsequent use; The mother solution extracted after volatile oil is for subsequent use; The Caulis et folium gaultheriae yunnanensis medicinal residues extracted after volatile oil are for subsequent use;
(3) the Caulis et folium gaultheriae yunnanensis medicinal residues after Herba Ophioglossi, Herba Polygoni Capitati and francolin tea extract volatile oil with step (2) is middle mix, add 8 times of volume water, boil extraction 1 time, each 3 hours, merge extractive liquid, mother solution after extracting volatile oil in extracting solution and step (2) merges, and obtains total extracting solution;
Total extracting solution centrifugal filtration, filtrate is condensed into thick paste, is mixed by thick paste with dextrin, makes granule, and dry, mixed homogeneously with step (2) gained volatile oil, Pulvis Talci, magnesium stearate by granule, tabletting, obtains tablet.
Embodiment 5
Prescription: Herba Ophioglossi 10g, Herba Polygoni Capitati 18g, Caulis et folium gaultheriae yunnanensis 18g, francolin tea 18g
Preparation method:
(1) Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea is taken;
(2) Caulis et folium gaultheriae yunnanensis extracts volatile oil, and volatile oil is for subsequent use; The mother solution extracted after volatile oil is for subsequent use; The Caulis et folium gaultheriae yunnanensis medicinal residues extracted after volatile oil are for subsequent use;
(3) the Caulis et folium gaultheriae yunnanensis medicinal residues after Herba Ophioglossi, Herba Polygoni Capitati and francolin tea extract volatile oil with step (2) is middle mix, add 14 times of volume water, boil extraction 3 times, each 1 hour, merge extractive liquid, mother solution after extracting volatile oil in extracting solution and step (2) merges, and obtains total extracting solution;
Total extracting solution centrifugal filtration, filtrate is condensed into thick paste, and mix homogeneously with the Macrogol 4000 of step (2) gained volatile oil, thawing, dripping becomes drop pill, obtains drop pill.
Embodiment 6
Prescription: Herba Ophioglossi 10g, Herba Polygoni Capitati 10g, Caulis et folium gaultheriae yunnanensis 10g, francolin tea 10g
Preparation method:
(1) Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea is taken;
(2) Caulis et folium gaultheriae yunnanensis extracts volatile oil, and volatile oil HP-β-CD enclose is for subsequent use; The mother solution extracted after volatile oil is for subsequent use; The Caulis et folium gaultheriae yunnanensis medicinal residues extracted after volatile oil are for subsequent use;
(3) the Caulis et folium gaultheriae yunnanensis medicinal residues after Herba Ophioglossi, Herba Polygoni Capitati and francolin tea extract volatile oil with step (2) is middle mix, add 11 times of volume water, boil extraction 2 times, each 2 hours, merge extractive liquid, mother solution after extracting volatile oil in extracting solution and step (2) merges, and obtains total extracting solution;
Total extracting solution centrifugal filtration, filtrate is condensed into thick paste, is mixed by thick paste, make granule with the volatile oil of step (2) gained HP-β-CD enclose, appropriate dextrin and Icing Sugar, dry, i.e. obtained granule.
Embodiment 7
Prescription: Herba Ophioglossi 10g, Herba Polygoni Capitati 5g, Caulis et folium gaultheriae yunnanensis 5g, francolin tea 5g
Preparation method:
(1) Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea is taken;
(2) Caulis et folium gaultheriae yunnanensis extracts volatile oil, and volatile oil porous silica solidifies, for subsequent use; The mother solution extracted after volatile oil is for subsequent use; The Caulis et folium gaultheriae yunnanensis medicinal residues extracted after volatile oil are for subsequent use;
(3) the Caulis et folium gaultheriae yunnanensis medicinal residues after Herba Ophioglossi, Herba Polygoni Capitati and francolin tea extract volatile oil with step (2) is middle mix, add 10 times of volume water, boil extraction 2 times, each 2 hours, merge extractive liquid, mother solution after extracting volatile oil in extracting solution and step (2) merges, and obtains total extracting solution;
Total extracting solution centrifugal filtration, filtrate is condensed into thick paste, is mixed by thick paste with dextrin, makes granule, and dry, the volatile oil solidified with step (2) gained porous silica by granule, Pulvis Talci, magnesium stearate are mixed homogeneously, and tabletting, obtains tablet.
Embodiment 8
Prescription: Herba Ophioglossi 10g, Herba Polygoni Capitati 15g, Caulis et folium gaultheriae yunnanensis 15g, francolin tea 15g
Preparation method:
(1) Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea is taken;
(2) Caulis et folium gaultheriae yunnanensis extracts volatile oil, and volatile oil is for subsequent use; The mother solution extracted after volatile oil is for subsequent use; The Caulis et folium gaultheriae yunnanensis medicinal residues extracted after volatile oil are for subsequent use;
(3) the Caulis et folium gaultheriae yunnanensis medicinal residues after Herba Ophioglossi, Herba Polygoni Capitati and francolin tea extract volatile oil with step (2) is middle mix, add 12 times of volume water, boil extraction 2 times, each 2 hours, merge extractive liquid, mother solution after extracting volatile oil in extracting solution and step (2) merges, and obtains total extracting solution;
Total extracting solution centrifugal filtration, concentrated, add ethanol and reach 60% to ethanol content, precipitate with ethanol 48 hours, get supernatant and reclaim ethanol, add step (2) gained volatile oil and suitable quantity of water, activated carbon decolorizing, filter, dividing is filled in oral liquid bottle, and sterilizing, obtains oral liquid.
Embodiment 9 clinical drug therapeutic effect of the present invention
(1) physical data
Hospital clinical case, chooses sinusitis in patients's totally 475 examples, comprises acute sinusitis and chronic sinusitis, 35.8 years old mean age, be divided into four treatment groups and a matched group at random, often organize patient 95 example.Often organize sex, age, the course of disease etc. through statistical procedures, no significant difference (P>O.05), has comparability.
(2) Therapeutic Method
1. matched group patient gives magnolia flower rhinitis-treating pill (Guangzhou Zhongyi Medicine Industry Co., Ltd's production), and using by package insert, 7 days is 1 course for the treatment of.
2. treatment group is divided into treatment 1 group, treats 2 groups, treats 3 groups and treatment 4 groups, gives respectively by the Chinese medicine composition obtained by the embodiment of the present invention 3,6,7 and 8.
Usage and consumption: each embodiment gained is 1 consumption, every day twice 7th is a course for the treatment of.
(3) therapeutic outcome
Table 1 Chinese medicine composition totall effective rate in clinical treatment of the present invention and relapse rate result (%)
Note: compared with matched group, * P<0.05
In all cases, treat 2 courses for the treatment of.Therapeutic outcome is in table 1, to compare the total effective rate 73.7% of matched group, the total effective rate of four treatment groups is respectively 92.6%, 91.6%, 92.6% and 93.7%, all significantly raise, difference has statistical significance (P<0.05), shows that Chinese medicine composition of the present invention is obviously better than matched group for sinusitis curative effect;
To compare the relapse rate 37.9% of matched group, the relapse rate of four treatment groups is respectively 4.2%, 4.2%, 6.3% and 5.3%, all significantly reduce, difference has statistical significance (P<0.05), show compared with matched group, Chinese medicine composition of the present invention can significantly reduce sinusitis relapse rate.
And treatments period, there are untoward reaction totally 28 examples in matched group, all patients for the treatment of group are showed no obvious adverse reaction, show that traditional Chinese medicine composition for treating sinusitis of the present invention is safe and effective, have no side effect.
Claims (9)
1. treat a Chinese medicine composition for sinusitis, it is characterized in that, it is at least made up of the raw material of following weight portion: Herba Ophioglossi 10 parts, Herba Polygoni Capitati 2-18 part, Caulis et folium gaultheriae yunnanensis 2-18 part, francolin tea 2-18 part.
2. the Chinese medicine composition for the treatment of sinusitis according to claim 1, is characterized in that, it is at least made up of the raw material of following weight portion: Herba Ophioglossi 10 parts, Herba Polygoni Capitati 5-15 part, Caulis et folium gaultheriae yunnanensis 5-15 part, francolin tea 5-15 part.
3. the Chinese medicine composition for the treatment of sinusitis according to claim 1, is characterized in that, it is at least made up of the raw material of following weight portion: Herba Ophioglossi 10 parts, Herba Polygoni Capitati 10 parts, Caulis et folium gaultheriae yunnanensis 10 parts, francolin tea 10 parts.
4. profit requires the preparation method for the treatment of sinusitis Chinese medicine composition described in any one of 1-3, it is characterized in that, mainly comprises the steps:
Take Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea, mixing, soaks, and decocts, to obtain final product;
Or mainly comprise the steps:
(1) Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea is taken;
(2) Caulis et folium gaultheriae yunnanensis extracts volatile oil, and volatile oil is for subsequent use; The mother solution extracted after volatile oil is for subsequent use; The Caulis et folium gaultheriae yunnanensis medicinal residues extracted after volatile oil are for subsequent use;
(3) the Caulis et folium gaultheriae yunnanensis medicinal residues after extracting volatile oil in Herba Ophioglossi, Herba Polygoni Capitati and francolin tea and step (2) mix, extracting in water, extracting solution and step (2) is middle extract volatile oil after mother solution merge, obtain total extracting solution; Total extracting solution and the middle volatile oil extracted of step (2) are with the use of the Chinese medicine composition as described treatment sinusitis.
5. the preparation method for the treatment of sinusitis Chinese medicine composition according to claim 4, is characterized in that, mainly comprise the steps:
Take Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea, mixing, add 8-12 times of water soaking 0.5-1.5h, decoct 1-3 time, each 1-2h, collecting decoction, to obtain final product;
Or mainly comprise the steps:
(1) Herba Ophioglossi, Herba Polygoni Capitati, Caulis et folium gaultheriae yunnanensis and francolin tea is taken;
(2) Caulis et folium gaultheriae yunnanensis extracts volatile oil, and volatile oil is for subsequent use; The mother solution extracted after volatile oil is for subsequent use; The Caulis et folium gaultheriae yunnanensis medicinal residues extracted after volatile oil are for subsequent use;
(3) the Caulis et folium gaultheriae yunnanensis medicinal residues after Herba Ophioglossi, Herba Polygoni Capitati and francolin tea extract volatile oil with step (2) is middle mix, add 8-14 times of volume water, boil and extract 1-3 time, each 1-3 hour, merge extractive liquid, mother solution after extracting volatile oil in extracting solution and step (2) merges, and obtains total extracting solution; Total extracting solution and the middle volatile oil extracted of step (2) are with the use of the Chinese medicine composition as described treatment sinusitis.
6. the preparation method for the treatment of sinusitis Chinese medicine composition according to claim 4, is characterized in that: described volatile oil with porous silica solidification or can use cyclodextrin inclusion compound.
7. the application of Chinese medicine composition described in any one of claim 1-3 in preparation treatment sinusitis medicine.
8. application according to claim 7, is characterized in that: by described Chinese medicine composition conveniently formulation method make oral formulations.
9. application according to claim 8, is characterized in that: described oral formulations is tablet, capsule, oral liquid, granule, powder, pill or drop pill.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306840A (en) * | 2000-01-30 | 2001-08-08 | 刘朝兵 | Chinese medicine for treating acute and chronic rhinitis and nasosinusitis |
| CN103405595A (en) * | 2013-08-19 | 2013-11-27 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treating paranasal sinusitis |
| CN103405596A (en) * | 2013-08-19 | 2013-11-27 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treating sinusitis |
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- 2015-06-09 CN CN201510314418.4A patent/CN104887765A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306840A (en) * | 2000-01-30 | 2001-08-08 | 刘朝兵 | Chinese medicine for treating acute and chronic rhinitis and nasosinusitis |
| CN103405595A (en) * | 2013-08-19 | 2013-11-27 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treating paranasal sinusitis |
| CN103405596A (en) * | 2013-08-19 | 2013-11-27 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treating sinusitis |
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