CN1048867C - Antiplaque antibacterial oral composition - Google Patents
Antiplaque antibacterial oral composition Download PDFInfo
- Publication number
- CN1048867C CN1048867C CN89109648A CN89109648A CN1048867C CN 1048867 C CN1048867 C CN 1048867C CN 89109648 A CN89109648 A CN 89109648A CN 89109648 A CN89109648 A CN 89109648A CN 1048867 C CN1048867 C CN 1048867C
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- CN
- China
- Prior art keywords
- dentifrice
- agent
- antibacterial
- group
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 62
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 230000002882 anti-plaque Effects 0.000 title abstract 3
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- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- HNEGQIOMVPPMNR-NSCUHMNNSA-N mesaconic acid Chemical compound OC(=O)C(/C)=C/C(O)=O HNEGQIOMVPPMNR-NSCUHMNNSA-N 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 125000005341 metaphosphate group Chemical group 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- HNEGQIOMVPPMNR-UHFFFAOYSA-N methylfumaric acid Natural products OC(=O)C(C)=CC(O)=O HNEGQIOMVPPMNR-UHFFFAOYSA-N 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 description 1
- 229940074371 monofluorophosphate Drugs 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- RHFUXPCCELGMFC-UHFFFAOYSA-N n-(6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-n-phenylmethoxyacetamide Chemical compound OC1C(C)(C)OC2=CC=C(C#N)C=C2C1N(C(=O)C)OCC1=CC=CC=C1 RHFUXPCCELGMFC-UHFFFAOYSA-N 0.000 description 1
- QWVGKYWNOKOFNN-UHFFFAOYSA-N o-methyl phenol Natural products CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- IWDCLRJOBJJRNH-UHFFFAOYSA-N para-hydroxytoluene Natural products CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 229940059574 pentaerithrityl Drugs 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- JYIZNFVTKLARKT-UHFFFAOYSA-N phenol;1,3,5-triazine-2,4,6-triamine Chemical compound OC1=CC=CC=C1.NC1=NC(N)=NC(N)=N1 JYIZNFVTKLARKT-UHFFFAOYSA-N 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 238000001259 photo etching Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 108010011110 polyarginine Proteins 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- BFDWBSRJQZPEEB-UHFFFAOYSA-L sodium fluorophosphate Chemical class [Na+].[Na+].[O-]P([O-])(F)=O BFDWBSRJQZPEEB-UHFFFAOYSA-L 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- 235000020354 squash Nutrition 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229920001909 styrene-acrylic polymer Polymers 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 229910021654 trace metal Inorganic materials 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan), and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, wherein said antiplaque agent is substantially completely dissolved in saliva present during tooth and gum cleaning in a solubilizing agent therefor. The solubilizing agent may be a humectant polyol such as propylene glycol, dipropylene glycol and hexylene glycol; a cellosolve such as methy cellosolve and ethyl cellosolve: a vegetable oil or wax containing at least about 12 carbon atoms in a straight chain such as olive oil, castor oil and petrolatum; or an ester such as ethyl acetate, amyl acetate, glyceryl tristearate and benzyl benzoate.
Description
The present invention relates to a kind of antimicrobial speckle mouth compound recipe dentifrice against corrosion.Especially, it relates to a kind of mouth compound recipe dentifrice that contains the water-insoluble in fact non-cationic antimicrobial agent that can effectively suppress plaque.
Opposite with tartar (on a kind of tooth hard calcification deposition), the tooth plaque is the soft deposition that is formed on the tooth.Different with tartar, plaque can form at any position of dental surface, particularly at the edge of gums.Therefore, except unbecoming, plaque is relevant with the generation of gingivitis.
Therefore, be starved of at mouth and add the known antimicrobial that reduces plaque in compound recipe.Usually, cationic antibacterial agent is adopted in suggestion.In addition, people such as Viston are at United States Patent (USP) 4,022, and having described in 880 provides the chemical compound (as anticalculus agent) of zinc ion can effectively delay the blended situation of antibacterial of plaque bacteria growing with another with one.The various antibacterial that share with zinc compound are described.These zinc compounds include cationic substance, and as guanidine, quaternary ammonium compound and non-cationic chemical compound are as halo salicylamide and halogenated hydroxyl diphenyl ether.In european patent application 0161,899, people such as Saxtox are described the antimicrobial speckle halogenated hydroxyl diphenyl ether against corrosion of non-cationic and triclosan and three share of hydration zinc citrate.Davis also is described the triclosan as toothpaste component (containing solubilizing agent such as propylene glycol) in european patent application 0271,332.
As antibiotic speckle agent against corrosion, cationic antimicrobial material such as chlohexidine, chlorination Benzth-onium and cetylpyridinium chloride are a large amount of Investigational objects.Yet, be not very effective usually when they use with anionic species.On the other hand, in oral administered compound, the non-cationic antibiotic substance can be compatible with anion component.
Yet typical oral administered compound usually is the mixture of multiple components, even resemble the performance that the so typical neutral substance of wetting agent also can influence compound recipe.
In addition, even non-cationic antimicrobial agent with the material of common employing, when share, its effect also is limited as condensed phosphate anticalculus agent (people such as Gaffar all is described in European patent 0251591 people such as UK Patent Application 00551 and Jackson).Common specified U.S.S.N.398,605 (registrations on August 25th, 1989) show, because the amount and the ratio that have added antimicrobial enhancing agent (AEA) (it can strengthen release and the reservation of described antibacterial at oral surfaces) and suitable condensed phosphate and AEA is provided, speckle effect against corrosion has improved greatly.
The invention has the advantages that it provides one to include the mouth compound recipe that the inhibition plaque of water-insoluble non-cationic antimicrobial agent and AEA in fact forms, this compound recipe contains can make described antibacterial be dissolved in saliva, and reaches the acceptable liquid excipient of mouth of effective speckle dosage against corrosion.
It is a spot of that the further advantage of the present invention is that AEA has strengthened, but release and the reservation of the antibacterial of effective speckle amount against corrosion on tooth and oral soft tissue.
Further advantages of the invention are that the speckle oral administered compound against corrosion that is provided can reduce the generation of gingivitis effectively.
Other advantage of the present invention will display from following detailed description.
According to some aspect of the present invention, it relates to one and contains effective speckle dosage against corrosion, water-insoluble non-cationic antimicrobial agent and about 0.005~4% (percentage by weight) antimicrobial enhancing agent (it can strengthen release and the reservation of described antibacterial at oral surfaces) and oral acceptable excipient in fact, this excipient can make described antibacterial be dissolved in saliva effectively, and reaching effective speckle dosage against corrosion, described oral administered compound has been removed the condensed phosphate anticalculus agent in fact from.
Typically, particularly consider that from speckle effect against corrosion, safety and prescription etc. comparatively ideal water-insoluble non-cationic antimicrobial agent example has:
Halogenated diphenyl ether
2 ', 4,4 '-three chloro-2-hydroxyl-diphenyl ether (Triclosan)
2,2 '-dihydroxy-5,5 '-two bromo-diphenyl ether
Halo salicylamide class
4 ', 5-dibromo salicylamide
3,4 ', 5-trichlorine salicylamide
3,4 ', 5-tribromo salicylamide
2,3,3 ', 5-tetrachloro salicylamide
3,3,3 ', 5-tetrachloro salicylamide
3,5-two bromo-3 '-the trifluoromethyl salicylamide
5-n-octyl-3 '-the trifluoromethyl salicylamide
3,5-two bromo-4 '-the trifluoromethyl salicylamide
3,5-two bromo-3 '-trifluoromethyl salicylamide (Flurop-hene)
Benzoates
Methyl-p-Hydroxybenzoate
Ethyl-p-Hydroxybenzoate
Propyl group-p-Hydroxybenzoate
Butyl-p-Hydroxybenzoate
Halo carbanilide class
3,4,4 '-the trichlorine carbanilide
3-trifluoromethyl-4,4 '-the dichloro carbanilide
3,3,4 '-the trichlorine carbanilide
Phenol compound (comprises phenol and its homologue, single and poly-alkyl and fragrant halo (as F, Cl, Br, I) phenol, resorcinol and catechol and their derivant, and bisphenol compound)
Phenol and its homologue class
Phenol
2 methyl-phenol
3 methyl-phenol
4 methyl-phenol
4 ethyls-phenol
2,4-dimethyl-phenol
2,5-dimethyl-phenol
3,4-dimethyl-phenol
2,6-dimethyl-phenol
4-n-pro-pyl-phenol
4-normal-butyl-phenol
4-n-pentyl-phenol 4-tertiary pentyl-phenol 4-is base-phenol 4-n-heptyl-phenol 2-methoxyl group-4-(2-acrylic)-phenol (acetaminol) 2-isopropyl-5-methyl-phenol (thymol) just
Single and poly-alkyl and aralkyl halogeno-benzene phenols methyl-parachlorophenol ethyl-parachlorophenol n-pro-pyl-parachlorophenol normal-butyl-parachlorophenol n-pentyl-parachlorophenol sec-amyl-parachlorophenol just base-parachlorophenol cyclohexyl-parachlorophenol n-heptyl-parachlorophenol n-octyl-parachlorophenol o-chlorphenol methyl-o-chlorphenol ethyl-o-chlorphenol n-pro-pyl-o-chlorphenol normal-butyl-o-chlorphenol n-pentyl-o-chlorphenol tertiary pentyl-o-chlorphenol just the adjacent benzyl of base-o-chlorphenol n-heptyl-o-chlorphenol parachlorophenol-adjacent benzyl of parachlorophenol-adjacent benzyl of a methyl-parachlorophenol-; Between the adjacent phenethyl of the dimethyl-parachlorophenol-adjacent phenethyl of a parachlorophenol-methyl-parachlorophenol 3-methyl-parachlorophenol 3; 5-dimethyl-parachlorophenol 6-ethyl-3-methyl-parachlorophenol 6-n-pro-pyl-3-methyl-parachlorophenol 6-isopropyl-3-methyl-parachlorophenol 2-ethyl-3; 5-dimethyl-parachlorophenol 6-sec-butyl-3-methyl-parachlorophenol 2-isopropyl-3; 5-dimethyl-parachlorophenol 6-diethyl methyl-3-methyl-parachlorophenol 6-isopropyl-2-ethyl-3-methyl-parachlorophenol 2-sec-amyl-3; 5-dimethyl-parachlorophenol 2-diethyl methyl-3; 5-dimethyl-parachlorophenol 6-secondary octyl-3-methyl-parachlorophenol p bromophenol methyl-p bromophenol ethyl-p bromophenol n-pro-pyl-p bromophenol normal-butyl-p bromophenol n-pentyl-p bromophenol sec-amyl-p bromophenol just base-p bromophenol cyclohexyl-p bromophenol o-bromophenol tertiary pentyl-o-bromophenol just base-o-bromophenol n-pro-pyl-; Between dimethyl-adjacent bromophenol 2-phenylphenol 4-chloro-2-methyl phenol 4-chloro-3-methylphenol 4-chloro-3; 5-xylenol 2; 4-two chloro-3; 5-xylenol 3; 4; 5; 6-tetrabromobisphenol-methylphenol 5-methyl-2-amyl phenol 4-isopropyl-3-methylphenol 5-chlorine-2-hydroxyl diphenyl methane resorcinol and derivative class resorcinol methyl-resorcinol ethyl-resorcinol n-pro-pyl-resorcinol normal-butyl-resorcinol n-pentyl-resorcinol thereof be base-resorcinol n-heptyl-resorcinol n-octyl-resorcinol n-nonyl-resorcinol phenyl-resorcinol benzyl-resorcinol phenethyl-resorcinol arylate base-resorcinol p-chlorobenzyl-resorcinol 5-chloro-2 just; 4-dihydroxy diphenyl methane 4 '-chloro-2; 4-dihydroxy diphenyl methane 5-bromo-2; 4-dihydroxy diphenyl methane 4 " bromo-2,4-dihydroxy diphenyl methane
Bisphenol compound class bisphenol-A 2,2 '-di-2-ethylhexylphosphine oxide (4-chlorophenol)
2,2 '-di-2-ethylhexylphosphine oxide (3,4, the 6-trichlorophenol, 2,4,6,-T) (AT-7)
2,2 '-di-2-ethylhexylphosphine oxide (4-chloro-6-bromophenol)
Two (2-hydroxyl-3,5-Dichlorobenzene base) sulfide
Two (2-hydroxyl-5-benzyl chloride base) sulfide
Be present in mouthful a speckle dosage effective against corrosion with the non-cationic antimicrobial agent in the compound recipe, for dentifrice, typically be about 0.01%~5% (percentage by weight, down together), be about 0.03%~1% preferably, better be about 0.25%~0.5% or about 0.25%~less than 0.5%, best is about 0.25%~0.35%, and according to appointment 0.3%; For collutory or liquid teeth cleaning agent, be about 0.03%~0.3% preferably, best is about 0.03%~0.1%.Antibacterial is water-insoluble in fact, and its implication is under 25 ℃, and its dissolubility in water is approximately less than 1% (percentage by weight), even approximately less than 0.1%.
Halogenated diphenyl ether is triclosan preferably.Phenolic compound has phenol preferably, thymol, and acetaminol, Crystoids and 2,2 '-di-2-ethylhexylphosphine oxide (4-chloro-6-bromophenol).Best speckle chemical compound antibiotic against corrosion is triclosan.As the antibacterial that a kind of and anticalculus agent (it can provide zinc ion) are share, Triclosan revealed in above-mentioned United States Patent (USP) 4,022,880, and Deutsche Bundespatent 3532860 has been described the situation that it and copper compound share in addition.The situation that it share with the tooth desensitizers that contains potassium ion source has then been described in the European patent 0278744.Triclosan also is used as speckle agent against corrosion and reveals out that the former contains lamellar liquid crystal surfactant activating agent phase through prescription in dentifrice, and it contains the stratiform space less than 6nm, and can at random contain zinc salt (Lame etc. are published in european patent application No. 0161898); In dentifrice, can contain simultaneously three hydration zinc citrates (Saxtox etc. are published in european patent application No. 0161899).
Adopted in the oral administered compound, the consumption of antimicrobial enhancing agent (AEA) (it can increase release and the reservation of above-mentioned antibacterial at oral surfaces) that can obtain effective potentiation is in about 0.005%~about 4% scope, be preferably about 0.1%~about 3%, better be about 0.5%~about 2.5% (all being weight percentage).
AEA can be the unification compound, be preferably polymerisable monomer, be more preferably polymer, a back term is generic fully, and for example it comprises oligomer, high polymer, two or more monomeric copolymers, ionomer, block copolymer, graft copolymer, cross linked polymer and copolymer or the like.AEA can be natural, also can be synthetic, and it can be the water-insoluble or (but hydration, hydrogel is shaped) of water (saliva) dissolubility or swellable preferably.Its mean molecule quantity is about 100~1, and 000,000, be about 1,000~1,000,000 preferably, better be about 2,000 or 2,500~250,000 or 500,000.
Usually, AEA contains one at least and discharges the enhancing group, and it is preferably tart, and as sulfonic acid, hypophosphorous acid perhaps better is hypophosphorous acid or carboxylic acid and their salt, for example alkali metal salts or ammonium salt.AEA also contains one at least and organically keeps and strengthen group, be more preferably contain one both tool discharge and strengthen, tool keeps the diversity that strengthens group again, a back group preferably has following general formula-(X)
n-R, its X are O, N, S, SO, SO
2, P, PO or Si etc., R is hydrophobic alkyl, alkenyl, acyl group, aryl, alkaryl, aralkyl, heterocyclic radical or their inert substitutive derivative, n are 0 or 1 or more (more than 1).Above-mentioned " inert substitutive derivative " is meant that those are generally the substituent on the non-hydrophilic R, they do not disturb the function (promptly strengthening the release and the reservation of antibacterial at oral surfaces) of desired AEA is significant, this class substituent has Cl, Br, I and carbonyl etc.Following form will illustrate this reservation enhancing group.N X-(X)
nR0 ... methyl, ethyl, propyl group, butyl, isopropyl, the tert-butyl group,
Cyclohexyl, pi-allyl, benzyl, phenyl, chlorophenyl, two
Tolyl, pyridine radicals, furyl, acetyl group, benzoyl
Bytyry, hydroquinone base etc.1 O ethyoxyl, benzyloxy, thioacetyl oxygen base, phenoxy group, carbonyl
Ethyoxyl, carbonyl benzyloxy etc.
The N ethylamino, diethylamino, propyl group amino, benzylamino
Benzamido, phenylacetyl amido etc.
S sulfo-butyl, sulfo-isobutyl group, sulfo-pi-allyl, sulfo-benzyl
Base, thio-phenyl, sulfo-propiono, phenyl ethanethioyl
Thiobenzoyl etc.
SO butyl sulfinyl, pi-allyl sulfinyl, benzyl sulfenyl
Base, phenyl sulfinyl etc.
SO
2The butyl sulfonyl, pi-allyl sulfonyl, benzyl sulfonyl, benzene
Base sulfonyl etc.
P diethyl phosphino-, ethyl vinyl phosphino-, methacrylic phosphine
Base, Ethylbenzyl phosphino-, ethylphenyl phosphino-etc.
PO diethyl phosphine oxygen base, ethyl vinyl phosphine oxygen base, methyl allyl
Base phosphine oxygen base, methyl-benzyl phosphine oxygen base, aminomethyl phenyl phosphine oxygen base
Deng.
S
iTrimethyl silyl, dimethylbutyl silicyl, dimethyl benzyl silicyl, dimethyl vinyl silicyl, dimethyl-allyl silicyl etc.
When using herein, discharge the enhancing group and be meant a kind of like this thing, its connects or in fact with adhesion, adhesive aggregation or otherwise in conjunction with AEA (being loaded with antibacterial), and takes it to oral cavity (for example tooth and gingiva) surface, thereby discharges antibacterial on these surfaces.It is hydrophobic that common organic reservation strengthens group, and it connects or with other combination antibacterial is connected with AEA, thereby has improved the reservation of antibacterial with respect to AEA, and has improved the reservation of antibacterial at oral surfaces indirectly.In some cases, the physics trapping effect that being connected of antibacterial and AEA is logical AEA realizes that particularly when AEA was a cross linked polymer, its structure provided the place for a kind of like this trapping inherently.The existence of many crosslinked groups in high-molecular weight existence and the cross linked polymer has further improved the physics trapping of crosslinked AEA polymer to antibacterial.
Preferably, AEA contains the anionic polymer that repeatability is formed unit (situation is that each unit contains a carbon atom at least preferably) on one chain or on the trunk, and directly or indirectly contain at least one unsettled unit price and discharge and strengthen group and a unsettled reservation increases group, they in pairs or be adjacent to or link to each other with atom (preferably carbon atom) on the chain with not really desirable combination.Second son situation preferably is, polymer can contain to discharge to strengthen group and/or keep and strengthens group and/or other pairs valency atom, or replace carbon atom or except that carbon atom and polymer chain in as the group of link, perhaps as the group of crosslink part.
People will be appreciated that, discharge example and the explanation that strengthens group and keep the AEA that strengthens group cited herein any not containing, and all needs with common known method it to be carried out chemical modification, obtains preferably, contain above-mentioned two kinds of groups, perhaps preferably have the AEA of two kinds of groups concurrently.For better polymerization AEA, for the verity that improves antibacterial to greatest extent and in the release of oral surfaces, satisfied situation is that the composition that polymeric chain or trunk (contain acid release and strengthen group) are gone up repeated unit is at least 10% of polymer, preferably, be at least 50%, be at least 80%~95% or 100% (percentage by weight) better.
According to preferred embodiment of the present invention, AEA comprises one and contains the polymer that repeats to form unit, and this repeats to form one or more phosphonic acids in the unit and discharges that to strengthen groups be to link to each other with one or more carbon atoms on the polymer chain.The example of this class AEA is poly-(vinylphosphonic acid), and what contain the following general formula of tool repeats to form unit:
Yet it does not contain and keep to strengthen group, and during back one type group was present in poly-(1-phosphono propylene), its general formula that repeats to form unit was:
The phosphonic AEA that contains preferably that adopt in this place is poly-(β-styryl phosphonic acid), and its general formula that repeats to form unit is:
Wherein, ph is a phenyl, phosphonic acids discharge to strengthen group and phenyl to be kept and strengthens group and be connected with adjacent atom on the chain, or form unit or have above-mentioned general formula I once in a while as repeating to form the β-styryl phosphonic acid of unit and the copolymer of ethylene phosphonic chloride for having general formula III repeating as an alternative, or be poly-(2-styryl phosphonic acid), what it contained the following general formula of tool repeats to form unit:
Wherein, discharge to strengthen and keep that to strengthen group be pairedly to link to each other with chain.
Usually, the molecular weight of the copolymer of these styryl phosphonic acid polymer and they and other inertia ethylene linkage unsaturated monomer is about 2,000~30, and 000, be 2,500~10,000 preferably.The 'inertia' monomer does not here significantly disturb for the function of any copolymer (here being used as AEA) expection.
Other contains phosphonic polymer and includes, phosphonic acids ethylene, and it has the following unit that repeats to form:
V-[(CH
2)
14CHPO
3H
2]
n-wherein, n can be an integer or makes the molecular weight of polymer reach about 3,000 value; Poly-(butylene-4,4-di 2 ethylhexyl phosphonic acid) sodium, it has the following unit that repeats to form:
Poly-(the two phosphonic acids ethylamines of pi-allyl), it has the following unit that repeats to form:
Other phosphonic acids polymer of describing in the european patent application 0321233, for example poly-(pi-allyl phosphono ethyl ester), phosphonic acids methacrylates etc. and paired pair of phosphonic acids fluidized polymer all can be used as AEA and use at this, certainly, if they contain or strengthen group by containing above-mentioned organic reservation after modifying.
Based on one aspect of the present invention, mouth contains a kind of mouth with compound recipe uses the non-cationic antimicrobial agent of water-insoluble in fact of acceptable excipient and a kind of effective dose, and have mean molecule quantity and be about 1,000~1,000,000 antimicrobial enhancing agent, and contain one at least and discharge to strengthen group and an organic reservation increases group, this medicament contains above-mentioned group, and these groups do not contain or do not contain water solublity synthetic anionic linear polymer in fact, the polycarboxylic acids alkali metal salts or ammonium salt, the molecular weight of these salts is about 1,000~1,000,000.
Another example preferably according to the present invention, AEA can contain the synthetic anionic polycarboxylate.As people such as Gaffar at United States Patent (USP) 4,627, disclosed such in 977, be about 1,000~1 although have molecular weight, 000,000 (is 30 preferably, 000~500,000) synthetic anionic polymer polycarboxylate is not used and poly phosphate anticalculus agent combined effect together in the present invention, but is used as the inhibitor of the alkaline phosphatase (the dehydration phosphoric acid salt with linear molecule) that makes the anti-calculus effect perfect.In fact, any composition that just polymeric polycarboxylate is reached as the dehydration phosphoric acid salt that contains linear molecule in the UK Patent Application 2200551 in the formula of oral of the insoluble non-cationic antimicrobial agent of water was in fact done open.Further observing context of the present invention can find out, when with another kind of composition (promptly linear dehydration poly-phosphide) combined effect situation under, when the coefficient with it composition of polymeric polycarboxylate did not exist, this class polycarboxylate was to improving non-ionic antibacterial agents and speckle agent against corrosion in the release of oral surfaces and remain with significant effect.For example, when especially being non-cationic antimicrobial agent with the coefficient composition of polymeric polycarboxylate.
Synthetic anionic polymer polycarboxylate and the complex that has various antibacterial, zinc and magnesium thereof have been used as anticalculus agent itself, have done openly in many previous patents, and for example, Shedlovsky is at United States Patent (USP) 3,429, in 963; Gaffar is at United States Patent (USP) 4,152, in 420; People such as Dichter are at United States Patent (USP) 3,956, in 480; Gaffar is at United States Patent (USP) 4,138, in 477; People such as Gaffar are at United States Patent (USP) 4,183, in 914 or the like.Should be understood that, when contain or modified make it to contain with a hook at the end when strengthening group, disclosed synthetic anionic polymer polycarboxylate is effectively in compound recipe in these patents, therefrom with reference to these methods of the present invention and these disclosures, has been specialized to a certain extent.
Here applied synthetic anionic polymer polycarboxylate is known usually, and commonly used is the form of its free acid, or be preferably part, better be whole neutral water insoluble alkali metal (for example, potassium, preferably sodium) or ammonium salt classes.Ratio is 1: 4~4: 1 the maleic anhydride or the copolymer of acid and other polymerisable ethylene linkage unsaturated monomer preferably, is methyl vinyl ether/maleic anhydride preferably, and its molecular weight (N.W.) is about 30,000~1,000,000, be preferably 30,000~500,000.These copolymers can be buied in market as trade name with Gantrez, as AN139 (M.W.500,000), and AN119 (M.W.250,000); Be preferably GAF company and produce the S-97 of pharmaceutical grades (M.W.) 70,000.
Other contains or modifiedly makes it to contain the effective polymeric polycarboxylate of AEA of withing a hook at the end and strengthening group, comprise that those are at above-mentioned United States Patent (USP) 3,956, disclosed in 480, as 1: 1 maleic anhydride and ethyl acrylate, the methacrylate hydroxyethyl ester, the copolymer of N-vinyl-alpha-pyrrolidone or ethylene, the back is a kind of with Mons à nto EMANO.1103 (M.W.10,000) and EMA61 level, can buy as trade name.Above-mentioned polycarboxylate also comprises acrylic acid and methyl or ethoxy methylmethacrylate or hydroxyethyl ester acrylic acid methyl ester. or ethyl ester, isobutyl ester, the copolymer of IVE or N-vinyl-alpha-pyrrolidone.
Other is at above-mentioned United States Patent (USP) 4,138,477 and 4, in 183,914 disclosed contain or modified make it to contain to a hook at the end strengthen the effective polymeric polycarboxylate of group, comprise maleic anhydride and styrene, isobutene. or ethyl vinyl ether, polyacrylic acid, polymethylene succinic acid, the copolymer of poly, and molecular weight is low to moderate 1,000 sulfo group acrylic acid oligomer is a trade name with Uniroyal ND-2, can buy.
It has been generally acknowledged that suitable is that the reservation that contains polymerisable ethylene linkage or vinyl unsaturated carboxylic acid strengthens group, this class carboxylic acid contains two keys of active carbon-to-carbon ethylene linkage, because these C=C are in monomer molecule or be in alpha-beta position with respect to carboxyl, or be the part of terminal methylene group, so they are easy to play the effect of polymerization reaction take place.The example of this class acid has: acrylic acid, methacrylate, senecioic acid, α-Lv Daibingxisuan, .beta.-methylacrylic acid, β-propylene propanoic acid, sorbic acid, alpha-chloro sorbic acid, cinnamic acid, β-styrene acrylic, muconic acid, itaconic acid, citraconic acid, mesaconic acid, glutaconate, equisetic acid, atropic acid, 2 benzyl acrylic acid, 2-cyclohexyl acrylic acid, angelic acid, umbellic acid, fumaric acid, maleic acid and anhydride.Other can with the ethylene linkage monomer of this class carboxylic acid monomer copolymerization, comprise vinyl acetate, ethlyene dichloride, dimethyl maleate or the like.Contain enough carboxylate groups in the copolymer for water-soluble.
In addition, another is useful herein, and is disclosed as the toothpaste composition, so-called carboxy vinyl polymer, and people such as Chown are at United States Patent (USP) 3,980, and 767; People such as Reberts are at United States Patent (USP) 3,935, and 306; People such as Perla are at United States Patent (USP) 3,919, and 409; Harrison is at United States Patent (USP) 3,911,904 and people such as Colodney at United States Patent (USP) 3,711, all it has been done in 604 open.They are buied commercial, for example, and the Car-bopol 934,940 and 941 (registered trade mark) of B.F.Goodrich company.These products mainly are made up of colloidal water-soluble polypropylene acid polymer, this polymer be with about 0.75%~2.0% polyene propyl group sucrose or polyene propyl group tetramethylolmethane (as cross-linking agent) crosslinked, effect such as catch provides required reservation potentiation by hydrophobicity and/or to the physics of antibacterial for this cross-linked structure and cross-bond.Poly is looked organic substance more or less has some similar, as with less than the crosslinked polyacrylic acid of 0.2% DIETHYLENE GLYCOL, the hydrophobicity of its low ratio and low-molecular-weight and/or this cross-linking agent tends to provide seldom or does not provide fully reservation potentiation.2,5-dimethyl-1, the 5-hexadiene can be for effectively keeping the example that strengthens cross-linking agent as one.
The composition of the polymeric polycarboxylate of synthetic anionic, be mainly and contain halogen arbitrarily or contain the oxygen substituent and existing and groups such as ester, ether and the carboxyl Hydrocarbon of bonding mutually, and be about 0.05%~4% with content, being 0.05%~3% preferably, is in the compound recipe that was applied to having prepared in 0.1%~2% o'clock better.
AEA also can comprise the polycarboxylate of the natural anionic polymerisation that containing withs a hook at the end strengthens group.The release that lacks above-mentioned definition strengthens and/or keeps the carboxymethyl cellulose of enhancing group.It is invalid as AEA that other bridging agent and glued membrane form agent.
Contain the example that hypophosphorous acid and/or sulfonic acid discharge the AEA that strengthens group as an illustration, will mention the polymer and the copolymer that contain unit or group, these units or group are by vinyl or pi-allyl hypophosphorous acid and/or sulfonic acid (as required, carbon atom on 1 or 2 (or 3) position is strengthened group by organic reservation and replaces) polymer-derived, for example, has the general formula of above-mentioned definition-(X)
n-RO can adopt these monomeric mixture, also can adopt them to have the copolymer of one or more inertia polymerizable ethylene linkage unsaturated monomers, as above-mentioned about the polymeric polycarboxylate of those effective synthetic anionics.Note as meeting, in these and other effective AEA, usually only have one acid discharge strengthen group be with polymer backbone or its branch on any specific carbon atom or other atom link to each other.Contain or the modified release that makes it to contain side group strengthens group and keeps the polysiloxanes that strengthens group and also can be used as AEA and use at this.Example as effective AEA will be to contain or the modified ionomer that makes it to contain release and keep the enhancing group.Kirk Othmer Encyc-lopeclia of Chemical Technology (third edition, ancillary volume, John Wiley ﹠amp; Sons company, all rights reserved, 1984) described ionomer on 546~573 pages in the book, this description is incorporated into by list of references.Here as the effective example of AEA be (suppose they contain or modified make it to contain to a hook at the end strengthen group) polyester, polyurethane and synthetic and natural polyamide (comprise protein and protein material, as collagen protein, poly arginine and other polymeric amino acid).
In the present invention, mean molecule quantity is approximately 1,000 to 1,000,000 AEA contains at least one and discharges the enhancing group, and contain an organic reservation at least and strengthen group, the described reagent that contains above-mentioned group does not contain or is substantially free of the alkali metal or the ammonium salt of water miscible synthetic anionic linear polymer polycarboxylic acids, and its molecular weight is about 1,000 to 1,000,000.
In the present invention, mouth is had an appointment 0.3% (weight ratio) antibacterial (as triclosan) and is contained 1.5~2% (weight ratio) polycarboxylate of having an appointment as AEA for containing with prescription preferably.
Irrelevant with theory, it is believed that AEA, particularly polymerism AEA is generally the anion film-forming material, and can imagine it is placed on dental surface, and forms successive film on this surface, thereby stops antibacterial to adhere to tooth.May be that non-cationic antimicrobial agent and AEA form complex, or other type of attachment, thereby form the film of complex or similar film at dental surface.It seems that the film property of AEA and promote antibacterial in the characteristic that dental surface discharges and keeps be because AEA causes dental surface to be not suitable for accumulation of bacteria, particularly because the direct bacteriostasis of antibacterial, thereby controlled the growth of antibacterial.Therefore, by 1) promote to discharge 2) keep 3 for a long time at dental surface) stop bacterial adhesion in the combination of three kinds of binding modes such as dental surface, make this mouthful with filling a prescription more effective aspect the minimizing plaque.Dental bed and near oral soft tissue on reached similar speckle effect against corrosion.
According to the present invention, mouthful make effectively basically that water insoluble non-cationic anti-bacterial is dissolved in the saliva with acceptable excipient, reach the effective dosage of speckle against corrosion.
With in the preparation, mouth includes the water that wetting agent exists with acceptable excipient at mouth.In gel dentifrice, typically contain weight and be 5~30% siliceous buffing compound, the typical content of water is at least 3% (weight ratio), generally be approximately 3~35%, wetting agent is preferably glycerol and/or sorbitol, and typical total amount is about mouthful of 6.5~75% or 80% (weight ratio) with the gel dentifrice prescription.To the inquiry of sorbitol situation, can be it as typical, commerce can be buied 70% aqueous solution.
When antibacterial content was approximately 0.25~0.35% (weight ratio), though can at random allow solubilizing agent exist, gel dentifrice did not also require at mouth and adds the solubilizing agent of other composition as antibacterial in excipient.When antibacterial content is lower than about 0.25% (weight ratio), for example be approximately 0.01~0.25% (weight ratio), then should there be solubilizing agent to exist, guaranteeing that antibacterial has enough dissolubility in saliva, thereby speckle effect against corrosion is arranged.(weight ratio) is 5% such as being about 0.35~0.5% or mostly when antibacterial content is higher than 0.35%, just should have solubilizing agent to exist, otherwise a large amount of antibacterial can not dissolve.
When very moment is had an appointment the acceptable buffing compound of 30~75% (weight ratio) dentistry with prescription for containing, also can at random allow this type of solubilizing agent exist.
Very moment is with prescription when being collutory or liquid teeth cleaning agent, mouthful with comprising surfactant in the excipient at least, flavored oils or non-toxic alcohol, they central each all assist to dissolve antibacterial.Moreover the existence of these solubilizing agents also is optional.
Of the present invention mouthful of solubilizing agent with existence in filling a prescription, about 0.5~20% (weight ratio) of its typical content, when the content of water-insoluble non-cationic antimicrobial agent hangs down basically (about 0.3%), then little solubilizing agent to about about 0.5% (weight ratios) is just enough.As a large amount of antibacterial, as have about 0.5% (weight ratios) at least when existing, and especially when the siliceous buffing compound that about 5~30% (weight ratios) are also arranged exists, then need (weight ratio) solubilizing agent of about 5% at least, typically be about 20% or higher (weight ratio).When solubilizing agent that it should be noted that nearly 5% (weight ratio) existed, perhaps dentifrice had the biphase trend of the solid-liquid of being divided into.
Existingly maybe may exist, the solubilizing agent that antibacterial is solubilized in the saliva can mix in the moistening excipient of aqueous.This solubilizing agent comprises the wettability polyalcohols, as propylene glycol, and dipropylene glycol and hexanediol, cellosolve such as methyl cellosolve and ethyl cellosolve, vegetable oil and straight chain contain the wax of about 12 carbon atoms at least, as olive oil, Oleum Ricini and vaseline; Also have esters such as pentyl acetate, ethyl acetate and benzyl benzoate." propylene glycol " used herein comprises 1,2-propylene glycol and 1, ammediol.Should avoid using a large amount of Polyethylene Glycol, particularly molecular weight is 600 or bigger Polyethylene Glycol, and this is because Polyethylene Glycol has the effect of the antibacterial activity that suppresses non-cationic antimicrobial agent.For example, when Polyethylene Glycol (PEG) 600 and triclosan existed with 1: 25 weight ratio, the activity of antibacterial triclosan was reduced to 1/16 (promptly having reduced by 16 times) that does not have Polyethylene Glycol to exist.
According to the present invention, mouthful dentifrice with prescription can be gel state in fact, as gel dentifrice.This kind gel mouth contains silicon class tooth with the polishing material with preparation, polishes material preferably and comprises crystalline silica, and its grain diameter is approximately to 5 microns, and mean diameter is approximately 1.1 microns, and surface area is approximately 50,000cm
2/ gm also has silica gel or colloid silicon and complicated amorphous alkali aluminosilicate.
When adopting transparent or opaque gel, the buffing compound of colloid silicon class is useful especially.For example.The Syloid72 and the Syloid74 that sell with the SYlOID trade mark, or Santocel 100 or the alkali metal aluminosilicate complex (that is, in its substrate, combining the Silicon stone of aluminium oxide) sold with the SANTOCEL trade mark.Why particularly useful they are, be because be made up of gel like structure, and their refractive index approaches the refractive index of gel one liquid (comprising water and/or wetting agent) system commonly used in the dentifrice.
At the dentifrice of mouth with prescription, in toothpaste or gel formula, the common concentration (by weight) of polishing material is about 5% to about 30%.
In the present invention, when oral formulations is dentifrice, the acceptable excipient of mouth is then arranged, comprise the water that contains wetting agent, this wetting agent is preferably glycerol and/or sorbitol, wherein the water yield typically was for about 15~35% or 40% (by weight), glycerol and/or sorbitol content typically are about 20~75% (by weight), more typically be about 25~60% (weight ratios) (being benchmark all) with oral type dentifrice, need mention a bit: the indication sorbitol is meant typically, commercial 70% the aqueous solution of supplying.
In the present invention, this mouthful can be pasty state in fact with the dentifrice prescription, as toothpaste, although it may be gelatinous (really not so usually, because this siliceous buffing compound typical amounts is no more than 30% (w/w)) when adopting siliceous buffing compound.This mouthful contains acceptable buffing compound on the dentistry with the excipient of the dentifrice of prescription, water-insoluble buffing compound Polymeric sodium metaphosphate. for example, potassium metaphosphate, tricalcium phosphate, Tri-Compress, anhydrous dicalcium phosphate, calcium carbonate, aluminium silicate, hydrated alumina, Silicon stone, the mixture of the mixture between Bentonite and the above-claimed cpd or these chemical compounds and hard grind luminescent material.The hard grind luminescent material means: incinerating aluminium oxide and Zirconium orthosilicate., at United States Patent (USP) 3,070, the granular pattern thermosetting resin class material of describing in 510 (December in 1962 issues on the 15th) is as melamine-phenol and melocol and crosslinked epoxy polymer and polyesters.Polishing material comprises insoluble Polymeric sodium metaphosphate. preferably, dicalcium phosphate and hydrated alumina.
Many so-called " water-insoluble " polishing material be anionic property, also comprise in a small amount solubility thing.Thereby, can be by " ThorpeShi applied chemistry dictionary " 9 volumes, the described any suitable method of 510-511 page or leaf (the 4th edition) removes to prepare insoluble Polymeric sodium metaphosphate. with MadrellShi salt and KurrolShi salt and two kinds of forms of well-known insoluble Polymeric sodium metaphosphate., is the another example of the material that suits.Because the dissolubility of these metaphosphates in water is very small, so be called as insoluble metaphosphate (IMP).Have a spot of soluble phosphoric acid salt material to exist as impurity, shared usually percentage ratio is very little, as is 4% (by weight).If desired, the available water washing reduces or eliminates the soluble phosphate amount of substance and (be sure of that this material has comprised with regard to the sodium trimetaphosphate of insoluble metaphosphate for solubility.Insoluble Metaphosphoric acid alkali metal salt is typically used with its powdery granule, particle diameter greater than 37 microns must not be more than 1% of overall material.
Hydrated alumina is an example of nonionic polishing material basically.Typically, its particle diameter is little, and promptly about at least 85% granule classifies as three water aluminum (ore deposit) (α-Alumina hydrate), usually with chemical formula AL less than 20 microns
2O
3.3H
2O or Al (OH)
3Expression.The particle mean size of three water aluminum is generally about 6~9 microns.Typical specification grade has following particle size distribution:
Micron percentage ratio
<30 94-99
<20 85-93
<10 56-67
<5 28-40
Cream stick with paste or gel formula in generally contain 30%~75% the polishing material (by weight) of having an appointment.
Natural or the synthetic thickening agent or the gellant that typically contain about 0.1~10% ratio in toothpaste or toothpaste type dentifrice and the gel dentifrice, better ratio is about 0.5~5%.A suitable thickening is the compound clay of synthetic colloidal magnesium, alkali silicate, and for example (as CP, SP2002 D) can buy as the Laponite that is sold by Laporte Industrial Co., Ltd.To the analysis showed that Laponite D carries out, be approximately 58.00%sio by weight
2, 25.40%Mgo, 3.05%Na
2O, 0.98%Li
2O, and some water and trace metal.Its self true ratio is 2.53, and its apparent bulk density is 1.0 (g/ml, dampness are 8% o'clock).
Other suitable thickening or gellant or thickening agent comprise Irish lichen, Iota-Carragllnan, Tragacanth, starch, polyvinylpyrrolidone, Cellulose ethyl hydroxypropyl ether, hydroxy butyl methyl cellulose, hydroxypropyl emthylcellulose, hydroxyethyl-cellulose (for example Natrosol that can buy), sodium carboxymethyl cellulose, and especially when siliceous buffing compound exists, comprise colloidal silica, can buy, as the Syloid244 or the Sylodent 15 of meticulous production as those.
When very moment was collutory or liquid teeth cleaning agent with prescription in the present invention, its character was essentially liquid, and special excipient in collutory is typical water-pure mixed liquor.The weight ratio of general water and alcohol is about 3: 1 to 10: 1 in about 1: 1 to 20: 1 scope preferably, is about 4: 1 to 6: 1 better.The typical range of water in this type of preparation-pure mixed liquor total amount is to about 99.9% (weight ratio) from about 70%.Alcohol is avirulence alcohol, as ethanol or isopropyl alcohol.Wetting agents such as picture glycerol and sorbitol can exist by the amount of 10~30% (weight ratios).Liquid teeth cleaning agent typically contains 50~85% the water of having an appointment, and may contain the non-toxic alcohol of have an appointment 0.5~20% (weight ratio) and also may contain 10~40% the wetting agent of having an appointment, like glycerol and/or sorbitol.The indication sorbitol is typical, commercial 70% aqueous solution that gets.Ethanol is non-toxic alcohol preferably.Just as thinking flavored oils can assist to dissolve the water-insoluble non-cationic antimicrobial agent, ethanol also can play this effect.
As pointed, non-cationic antimicrobial agent is essentially water-insoluble.Yet, can believe that in the present invention AEA is as poly-carboxylic esters (being present in collutory and the liquid teeth cleaning agent), organic surface active agent, flavored oils or non-toxic alcohol can help the dissolving antibacterial and assist it to reach on the soft oral cavity tissue of dental bed or neighbouring and reach dental surface.As optional composition, organic surface active agent and/or flavored oils also can assist to dissolve antibacterial in mouth is filled a prescription with dentifrice.
In prescription of the present invention, also adopt organic surface active agent reaching the increase preventive effect, and assist speckle antibacterial against corrosion to be dispersed in the oral cavity for a full due, and make this more cosmeticsization of filling a prescription.Organic surface-active substance is preferably anionic property, nonionic or amphoteric, and preferably used as the surfactant of cleaning substance, clean and character foamy to give this prescription.The example that anion surfactant is suitable is the water soluble salt of high fatty acid monoglyceride monosulfate, as the sodium salt of hydrogenated coconut oleic acid monoglyceride sulfate mono; High alkyl sulfate is as lauryl sulfate; Alkylaryl sulfonates is as dodecylbenzene sodium sulfonate; High alkylthio acetate; 1, the high fatty acid ester of 2-dihydroxypropane sulfate, and the saturated senior fatty acyl group amide of lower member ester fat amino carboxylic acid compounds as on fatty acid, have those chemical compounds of 12~16 carbon atoms on alkyl or the acyl group, or the like.The example of last-mentioned amide is a N-lauroyl sarcosine, and the N-lauroyl, the sodium of N-myristoyl or N-palmityl sarcosine, and potassium and ethanolamine salt, they should not contain soap or similar higher fatty acid oily substance in fact.Has special advantage at of the present invention mouthful with these sarcosinates chemical compounds of employing in filling a prescription, this is owing to can play a role reducing the tooth enamel dissolution except these materials in acid solution, and they also have the formation (because due to saccharide degraded) of acid in the oral cavity and continue and significant inhibitory effect.The example of water soluble nonionic surfactant is the condensation substance of oxirane and various active hydrogen-contg compounds, Fan Ying hydrogen-containing compound (for example has long hydrophobic chain therewith, the aliphatic chain that 12 to 20 carbon atoms are arranged), this condensation substance contains hydrophilic polyoxyethylene segment part, as poly(ethylene oxide) and fatty acid, aliphatic alcohol, fatty acid amide, the condensation product of polyhydroxy-alcohol (as dehydration monostearate sorbitol) and polypropylene oxide (for example Pluronic material).
The surfactant typical content is about 0.5~5% (weight ratio), is about 1~2.5% preferably.
Very moment is with prescription when being liquid teeth cleaning agent, and described typical content ratio natural or synthetic thickening agent or gelatinizing agent is about 0.1~10%, is about 0.5~5% preferably.
Generally say, do not contain buffing compound in the liquid teeth cleaning agent.Yet; according to United States Patent (USP) 3; 506; 757 description (Salzmann is the applicant); the polysaccharide that can adopt about 0.3~2.0% (weight ratio) in liquid teeth cleaning agent is as suspending agent and thickening agent, and this polysaccharide contains mannose, glucose; (ratio is roughly 2: 1: 1: 1), molecular weight surpasses 100 ten thousand for glucuronic acid potassium and acetyl group segment part.In this liquid teeth cleaning agent, also can contain about 10~20% polishing material, hydrated alumina for example, Tri-Compress, calcium pyrophosphate, insoluble calcium metaphosphate, no aqueous dicalcium phosphate, calcium carbonate, magnesium carbonate, magnesium oxide, Silicon stone and composition thereof, or the like.
Be not bound by theory, thereby the present invention has obtained advantage.It is believed that property of water-bearing wetting agent excipient is solubilized into surfactant micella interior (as having gelatinizing agent and buffing compound in the dentifrice prescription, in then they are not included in) in the mobile phase.The mobile phase solution of dentifrice can be by saliva dilution, and saliva can make Triclosan be precipitated out.Thereby, even find under the situation that lacks special Triclosan, solubilizing agent.When the amount of Triclosan is about 0.25~0.35% (weight ratio), and when having AEA as polycarboxylate and so on to exist, on the soft tissue of dental bed, there is the Triclosan of q.s to exist, goes to bring into play its good speckle effect against corrosion.Other water-insoluble non-cationic antimicrobial agent described herein has obtained same attention.
Also can contain composition that fluoride sources maybe can provide fluorine as anti-caries agent in the dentifrice of mouth with prescription, its content should reach the fluorion that about 25ppm to 5000ppm can be provided.These chemical compounds can be water microsolubility or intact Jinsui River dissolubility.Their characteristic be in water releasing fluoride ion and with mouth with the prescription in other chemical compound generation untoward reaction.Comprise inorganic fluoride salts in these materials, as soluble alkali metal, alkali salt, sodium fluoride for example, potassium fluoride, ammonium fluoride, calcium fluoride, the fluoride of copper such as copper fluoride, zinc fluoride, barium fluoride, prodan, ammonium fluosilicate, sodium fluozirconate, ammonium fluozirconate, sodium monofluorophosphate, single and two fluorophosphoric acid ammonium and calcium pyrophosphate sodium.Be the fluoride of alkali metal and stannum preferably, for example sodium fluoride and stannous fluoride, sodium monofluorophosphate (MFP) and their mixture.
The content of confession fluorine compounds depends on the type of chemical compound in a way, its dissolubility, and the type of oral formulations, but it is necessary for non-toxic, is generally about 0.0005 to about 3.0% in preparation.In dentifrice formulation, with in the gel, can discharge approximately 5 as tooth, the content of this compounds of 000ppm fluorion (weight ratio in the preparation finished product) can be thought of as satisfied amount.Can adopt the suitable minimum of these chemical compounds, but discharging of the most handy enough chemical compound is about 300~2, the 000ppm fluorion, better about 800~1 for discharging, the 500ppm fluorion.
In the alkali metal fluoride example, this type of composition typical content is approximately to about 2% (by weight), is benchmark with the weight of preparation, preferably in about scope of 0.05% to 1%.In the sodium monofluorophosphate example, it is a large amount of 0.1~3% that this chemical compound can contain, and more typically is about 0.76%.
Conventionally this class mouth is sold and distributed after suitable labelling is packed with preparation, this point is understandable.Thereby the gel that will clean one's teeth usually is injected in the squeezable pipe, is typically aluminum, and the lead and the plastic tube of lining arranged; Or other squash type, in sucking type or the pressure type tuner, content is measured with this.Above-mentioned packing container has the label explanation outward, and the essence of these commodity is gel or the similar composition of cleaning one's teeth.
In filling a prescription, can mix various other materials such as bleach, antiseptic, silicone, chlorophyll compounds and/or ammino material such as carbamide, Diammonium phosphate (DAP) and their mixture at of the present invention mouthful.When these adjuvant existed, their content in preparation can not produce harmful effect to the character and the characteristics of expection in fact.Should avoid a large amount of zinc, magnesium and other slaine and normally easily molten, and can with the existence of the bonded material of activating agent composition among the present invention.
Any suitable seasoning or sweeting agent all may be utilized, and the example of suitable seasoning composition is a flavored oils, as Oleum Menthae Rotundifoliae, and Oleum menthae, wintergreen oil, Sassafras oil, Oleum Caryophylli, sage oil, Eucalyptus oil, Herba Origani oil, Oleum Cinnamomi, Fructus Citri Limoniae oil and citrus seed oil and methyl salicylate.Suitable sweeting agent comprises sucrose, lactose, maltose, xylitol, Cyclamen persicum sodium, perilla oil, AMP (aspartyl phenyl alanine methyl ester), glucide or the like.Suitable flavoring agent and sweeting agent can be separately or are present in together in the preparation, account for about about 0.1~5%.Elsewhere, identical with surfactant, be sure of flavored oils with surfactant, perhaps even when not having surfactant, can assist the dissolving antibacterial.
Putting into practice preferably when of the present invention, preferably among the present invention mouthful is applied on tooth enamel and the oral soft tissue regularly with filling a prescription, especially on the dental bed or near.Time is every day or per 2 days or per 3 days, or best every day 1~3 time, and pH value is about 4.5 to about 9 or 10, generally about 5.5~8, is preferably about 6~8, is preferably about 6.5~7.5, continues the week at least 2 weeks to 8 or all one's life of continuing.Even be lower than at 5 o'clock at pH value, tooth enamel is decalcification or round other destruction not.Usable acid (as citric acid or benzoic acid) or alkali (as sodium hydroxide) or buffer (sodium citrate, sodium benzoate, sodium carbonate or sodium bicarbonate, sodium hydrogen phosphate, sodium dihydrogen phosphate etc.) are controlled acid-base value.
Prescription among the present invention can be incorporated in lozenge, share in chewing gum or the other products, for example it can be admixed in the gelatinised matrix of heat, or it is wrapped in the outer surface of gelatinised matrix.Can be used as illustrations as gelutong, latex, vinylite etc., in the time of if desired, can with the plasticizer or the softening agent of routine, sugar or other sweeting agent or carbohydrate such as glucose, sorbitol etc. share.
Further specify essence of the present invention with following example, still, the present invention is limited.Except as otherwise noted, related all quantity and ratio be all by weight in this paper and appended " claim ".
Example 1
Prepare following dentifrice:
Component
A B
Glycerol 10.00-
Propylene glycol-10.00
Sorbitol (70%) 25.00 25.00
Iota?carrageenan 0.60 0.60
Gantrez?S-97 2.00 2.00
Saccharin sodium 0.40 0.40
Sodium fluoride 0.243 0.243
Sodium hydroxide (50%) 1.00 1.00
Titanium dioxide 0.50 0.50
Silicon stone buffing compound (Zeodent113) 20.00 20.00
Silicon stone thickening agent (Sylox15) 5.50 5.50
Sodium lauryl sulphate 2.00 2.00
Water 31.507 31.507
Triclosan 0.30 0.30
Flavored oils 0.95 0.95
The same basically with the dentifrice B that contains the special solubilizing agent of Triclosan.Above-mentioned dentifrice A is discharged into Triclosan on tooth and the soft gums, and in other words, dentifrice in the present invention need not special solubilizing agent just can produce effects.And, in corresponding dentifrice, there is not the Gantrez polycarboxylate, then be difficult to Triclosan is discharged.
In above-mentioned example, also can promptly use other antibacterial described herein by displacement (some composition) result that obtains improveing, phenol for example, thymol, acetaminol and 2,2 '-di-2-ethylhexylphosphine oxide (4-chloro-6-bromophenol) replaces triclosan; And/or replace Gantrez with other AEA, copolymer, sulfo-acrylic acid oligomer as 1: 1 maleic anhydride and ethyl acrylate, between carbopol Carbopols (for example 934) and α or β styryl phosphonic acid polymer of monomers and these monomers or with the undersaturated polymerisable monomer of other ethylene linkage, the copolymer that constitutes as ethylene phosphoric acid.
Example 2
Press example 1 described experimental procedure, following liquid phase dentifrice solution testing bag by absorption and the reservation situation of triclosan in the saliva on hydroxyapatite (HA) dish, drawn following result:
Ingredient components
A B C D sorbierite (70% solution) 30.0 30.0 30.0 30.0 glycerine 9.5 9.5 9.5 9.5 propane diols 0.5 0.5 0.5 0.5SLS 0.95 0.95 0.95 0.95Triclosan of 0.243 0.243 0.243 0.243 flavored oils 0.3 0.3 0.3 0.3 water 56.507 54.507 54.507 54.507 poly-(β-styryl phosphonic acid) 2.0 poly-(α-styryl phosphonic acid) 2.0 polyvinyl alcohol 2.0 usefulness NaoH transfer pH to 6; 5, in the reservation amount of the coated Triclosan, 31.0 174.0 86.0 36.0 microgram numbers that absorb of saliva Triclosan on the coated HA dish of saliva
Initial 183.0
After 30 minutes 136.0
After 1 hour 105.0
After 3 hours 83.0
The above results shows that the triclosan absorption value that contains solution (D) (the not being AEA hereinafter) generation of polyvinyl alcohol only is 36.0.Quite similar with the absorption value 31.0 of the contrast solution that does not have additive (A).On the contrary, solution (C) absorption value that contains poly-(α-styryl phosphonic acid) is 86.0, is solution (A) and (D) two times; And the absorption value that contains the solution (B) of poly-(β-styryl phosphonic acid) is solution (A) and (D) five times, further specifies release that the ortho position replaces and strengthens group and produce more superior result.After The above results was further illustrated in a period of time, the retention of triclosan in HA dish was good as wondrous, and this result obtains in poly-from containing (β-styryl phosphonic acid) solution B of (molecular weight is about 3,000 to 10,000).
Example 3
In experiment in vitro, estimated synthetic anionic linear polycarboxylate to water-insoluble, the non-cationic antibacterial is in the absorption of dental surface, the effect that keeps and discharge, external being meant on the hydroxyapatite in saliva coated (the deriving from Monsanto Company) dish and on the Cheek cell of flaking.This external assessment is relevant with the reservation that intravital release reaches at oral surfaces.
In order on the hydroxyapatite dish of saliva coated, to carry out the antibacterial release experiment, the hydroxyapatite (HA) that derives from Monsanto Company is washed with aquae destillata, vacuum filtration is collected, and 37 ℃ of following dried overnight.Exsiccant HA is clayed into power with mortar and pestle, and 150.00mg HA is put into the compression of kbr tablet punch die groove, and (Barnes Ana-lytical, Stanford CT.), or squeezed 6 minutes under 10,000 pounds, carried out on the Carver laboratory press.The 13mm dish of gained is placed the Thermolyne stove, 800 ℃ of following clinkerings 4 hours.The pure saliva collection that stimulates through class thin film (Parafilm) is in ice-cold glass beaker, and at 4 ℃ and 15,000xg (promptly taking advantage of gravity) centrifugal 15 minutes down makes saliva clarification.Under 4 ℃ of stirrings, use irradiation under ultraviolet ray sample 1 hour, with clarifying saliva sterilization.In the polyethylene test tube with sterilized water with each clinkering dish hydrated, remove then and anhydrate, change 2ml saliva.This coils in 37 ℃ of water-baths heat insulating culture and spends the night (needing continuous jolting), forms salivary pellicle.After this handles, remove saliva, and handle this dish with the liquid solution that 1.00ml contains the dentifrice of antibacterial Triclo-san, and in water-bath continuously under the jolting, in 37 ℃ of insulations.After 30 minutes, this dish is transferred in the new test tube, added 5ml water, use wortex device (Vortex) to shake this dish lightly subsequently.Then, this dish is transferred in the new test tube, and repeated washing step secondary.Carefully this dish is transferred in the new test tube at last, be avoided bringing into simultaneously any liquid.Then, in plate, add 1.00ml methanol, and with the violent jolting of Vortex.Sample was placed 30 minutes in room temperature,, then methanol is drawn out and centrifugal clarification (10,000 rev/mins of rotating speeds) 5 minutes on Beckman microcentrifuge 11 so that a Triclosan who absorbs is extracted in the methanol.Afterwards, methanol is moved to the interior antibacterial of measuring of bottle of HPLC (high performance liquid chromatography) instrument.Three duplicate samples are all used in all experiments.
In order to test the retention of antibacterial on the HA of saliva coated dish, the HA dish of saliva coated is handled with the dentifrice serosity as above-mentioned method., after 30 minutes the HA dish is migrated out from the dentifrice serosity 37 ℃ of insulations, wash secondary with water, then in the people's who stimulates through the class thin film pure saliva (centrifugal clarification), cultivate again.At 37 ℃, in different time, jolt consistently, HA dish is taken out from saliva, with the analytical method of HPLC be determined at dish go up reservation antibacterial (Triclosan) amount and be discharged into amount in the saliva.
In order to measure the release of antibacterial on Cheek cell, measure to discharge is in order to measure from the dentifrice product PVM/MA effect of delivery of antimicrobials in softish oral cavity tissue, scrape oral mucosa gently with wooden applicator stalk and collect Cheek cell, with cell suspension (50nM Nacl, 1.1nM Cacl in the RSS buffer
2, and 0.6nMKH
2PO
4, pH7.0), be 5-6 * 10 with blood cell cytometer counting
5Cells/ml, with before be kept in the ice.In 37 ℃ of water-baths, in the pre-incubated 5ml cell suspending liquid, add the antimicrobial of 0.5ml and 37 ℃ of cultivations.Antibacterial in cultivating mixed liquor will dilute 10 times at least, so that the destruction of reducing surfactant concentrations and preventing the surfactant cell membrane.Cultivate after 30 minutes this cell of centrifugal collection on Beckman microcentrifuge 11, (rotating speed is 5,000 rev/mins, and the time is 5 minutes).Collected globular cell is given a baby a bath on the third day after its birth inferior with the RSS buffer, and handles with 1.5ml methanol, sample is acutely mixed, with HPLC methods analyst antibacterial.
Preparation has the dentifrice of following prescription:
Component
A B propane diols (1,2) 10.00 10.00Iota Carrageenan 0.75 0.75Gantrez S-97-2.00 titanium dioxide 0.50 0.50 sorbierite (70%) 30.00 30.00 sodium fluoride 0.332 0.332 saccharin sodium, 0.40 0.40 silica thickener (Sylo-3.00 3.00 dent 15) silica buffing compound (Zeo-dent 113) 20.00 20.00Triclosan 0.20 0.20 lauryl sodium sulfate 2.00 2.00 flavored oils 0.95 0.95 ethanol, 1.00 1.00 water (adding to), 100.00 (adding to) 100.00
When containing polymeric polycarboxylate (Gantrez S-97) and when not containing it, the HA of saliva coated dish and on Cheek cell the absorption value of triclosan list in the tabulation-1 down:
Table-1 dentifrice microgram * 10 on the saliva coated dish
5
The Cheek cell of Triclosan
Absorption value (microgram)
A 25.0 38.0
B 54.0 96.0
This presentation of results Gantrez material (containing among the dentifrice B) has increased absorption and the release of triclosan on saliva coated HA dish and the Cheek cell in flaking widely.
When triclosan content is 0.30 in the dentifrice, similar result is arranged.
Example 4
In hydroxyapatite (HA) dish and the experiment of exfoliate Cheek cell with saliva coated, to dentifrice B, B ' and C, C ' compare.Contain 2.00% Gantrez S-97 and 0.20%triclosan, 10.00% propylene glycol and 2.00% sodium lauryl sulphate with different in the above-mentioned example 1, above-mentioned dentifrice B; The prescription of dentifrice B ' except that containing 0.30%triclosan, equal identical with B; Compare with the commercial dentifrice C that buys, it contains the hydrated alumina buffing compound, and (a) contains 0.2%triclosan, (b) no Gantrez material, (c) no propylene glycol, (d) 0.5% zinc citrate, (e) 2.5% surfactant, (f) sodium monofluorophosphate and hydrated alumina buffing compound; The prescription of dentifrice C ' is as follows, similar to commodity dentifrice C, except the content that has only 0.30%tric-losan is:
Dentifrice C '
%
Sorbitol 27.00
Sodium carboxymethyl cellulose 0.80
Sodium monofluorophosphate 0.85
Zinc citrate 0.50
Saccharin sodium 0.18
Water 16.47
Hydrated alumina buffing compound 50.00
Ethanol 0.20
Sodium lauryl sulphate 1.875
Dodecylbenzene sodium sulfonate 0.625
Triclosan 0.30
Flavoring agent 1.20
Because at dentifrice C and the middle surfactant total content of C ' is 2.50%, than more than 2.00% among dentifrice B and the B ', so more surfactant is arranged among C and the C ' in order to dissolving triclosan.Yet, guaranteed that at the propylene glycol (in hydrated aluminum buffing compound class dentifrice C and C ', not having) of siliceous buffing compound class dentifrice B and the middle existence of B ' the triclosan dissolving reaches optimum degree.
With regard to the absorption of triclosan on the Cheek cell that reaches on the hydroxyapatite dish of saliva coated in flaking, dentifrice B and B ' (containing propylene glycol and Gant-rez) are better than dentifrice C and C ', as follows shown in the tabulation-2:
Table-2
The release of Triclosan
To saliva coated to Cheek cell
Hydroxyapatite dish microgram * 10
6
(microgram) epithelial cell dentifrice
B 41.1 101.6
B 77.4 142.0
C 20.4 61.0
C′ 42.6 100.0
In addition, with 50% dentifrice B ' (0.3%Trlclosan; Gan-trez; Propylene glycol) serosity experimentizes, and measures the retention of triclosan on the hydroxyapatite dish of saliva coated in a period of time, and the reservation that this experiment the shows triclosan height of being on close level sees Table shown in-3.
Table-3
The retention of Triclosan absorption from the dentifrice serosity
Time (branch) retention (microgram/dish)
0 70
30 60
60 70
120 65
180 57
240 59
These results show and contain Triclosan, the dentifrice of Gantrez material and propylene glycol, can promote Triclosan on inner teeth gear surface, oral cavity and pressure release surface discharge and keep, thereby improved speckle against corrosion and antimicrobial effect.
Example 5
Prepared following prescription a and b for comparing:
Dentifrice
a b
% glycerine 10.00-propane diols-10.00Iota Carrageenan 0.60 0.60 sorbierite (70%) 25.00 25.00 saccharin sodium 0.40 0.40 sodium fluoride 0.243 0.243 titanium dioxide 0.50 0.50Gantrez S-97,2.00 2.00 water, 29.157 29.157NaoH (50%) 2.00 2.00Zeodent 113 (silicon 20.00 20.00 stone mill photo etchings) Sylodent 15 (silicon 5.50 5.50 flavor enhancements 1.10 1.10Triclosan 0.50 0.50 lauryl sodium sulfate 2.00 2.00 ethanol 1.00 1.00
Prescription a is for containing the Gantrez polycarboxylate, and 0.5%Triclosan is as antibiotic speckle agent against corrosion, and do not have the dentifrice of solubilizing agent.In prescription b, contain the solubilizing agent propylene glycol.
When on Cheek cell, discharging Triclosan, prescription a extreme difference.The good results are evident for b and fill a prescription.
The above results has showed and has discharged the very outstanding dentifrice of Triclosan.
Example 6
According to Addy, Wilis and Moran be at J.Clin, Perio, and 1983, Vol 10, and P.89~99 ten thousand methods described in have been carried out " inside " research to one group of volunteer, to estimate the influence of specific dentifrice to the plaque regrowth.The dentifrice test comprises one group of placebo group and dentifrice group that does not contain Triclosan (i).According to the present invention, this dentifrice contains 0.3%Triclosan, 10% propylene glycol (replacing 3% Macrogol 600), and 2%Gantrez S-97, the wetting agent of propylene glycol and sorbitol are (ii).The prescription of dentifrice is as follows:
Component
(i) (ii)
%
Placebo invention Macrogol 600 3.00-glycerine 25.00-propane diols-10.00 sorbierite (70%) 41.617 25.00 sodium carboxymethylcellulose 0.35-Iota Carrageenan-0.60 Sodium Benzoate 0.50-saccharin sodium 0.20 0.40 sodium fluoride 0.243 0.243 silica buffing compound (Zeodent113), 18.00 20.00 silica thickeners (Sylox 15) 5.50 5.50 water 3.00 28.757Gantrez S-97-2.00Triclosan-0.30 titanium dioxide 0.50 0.50 sodium lauryl sulfate 1.20 2.50 flavor enhancements 0.89 1.10 ethanol 1.00NaoH (50%) 2.00
The minimizing of relevant volunteer tooth plaque, (i) compares with placebo group, and the invention group has (ii) obviously reduced 20%.
Since toothpaste (ii) in, more a spot of propylene glycol also can dissolve 0.3% Triclosan, therefore, when the amount of propylene glycol reduces to 0.5% and the amount of sorbitol when rising to 39.5% also can obtain similar result.Equally, other solubilizing agent is as dipropylene glycol, hexanediol, methyl cellosolvo, ethyl-cellosolvo, olive oil, Oleum Ricini, vaseline, pentyl acetate, ethyl acetate, glyceryl tristearate and benzyl benzoate, substituted propylene glycol after, also can be discharged into Triclosan on the oral soft tissue effectively.And, when propylene glycol or other solubilizing agent from the toothpaste that contains 0.3%Tric-losan (ii) after the deletion, still can obtain similar result.
Example 7
Prepare following dentifrice of the present invention:
Component
A B glycerine-20.00 propane diols 10.00 0.50 sorbierites (70%) 25.00 19.50 sodium carboxymethylcelluloses-1.10Iota Carrageenan 0.600-saccharin sodium 0.40 0.30 sodium fluoride 0.243 0.243 silica buffing compound (Zeodent113) 20.00 20.00 silica thickeners (Sylox15) 5.50 3.00 water 28.757 15.307Gantrez S-97 2.00 2.00Triclosan 0.50 0.30 titanium dioxide 0.50 0.50 lauryl sodium sulfate 2.50 2.00 flavor enhancements 1.10 0.95 ethanol 1.00-NaOH (50%) 2.00 1.60
In above-mentioned example, replace the result that some composition can obtain improveing, as with other antibacterial such as phenol, thymol, acetaminol and 2,2 '-di-2-ethylhexylphosphine oxide (4-chloro-6-bromophenol) replaces Triclosan; And/or replace Gantrez with other AEA, the copolymer of 1: 1 maleic anhydride and ethyl acrylate for example, the acrylic acid oligomer of sulfo-, carbopol (Carbopols) for example 934, copolymer between α or β-styryl phosphonic acid polymer of monomers or these styryl phosphonic acid monomers, perhaps these styryl phosphonic acid monomers and other ethylene linkage unsaturated polymerizable monomer, the copolymer that constitutes as vinylphosphonic acid.
Example 8
Prepare following dentifrice:
Component
A B C α-hibbsite 48.00 48.00 48.00 propane diols-0.50 0.50 sorbierite (70%) 21.70 21.70 21.70Gantrez S-97 15.00 15.00-(13% solution) Gantrez S-97 (powder)--2.00 lauryl sodium sulfate, 2.00 2.13 2.13 saccharin sodiums, 0.30 0.30 0.30 NaOH (50%) 1.20 1.20 1.20 flavor enhancement, 0.95 0.95 0.95 Irish liver moss 1.00--sodium carboxymethylcellulose-1.00 1.00 sodium monofluorophosphates 0.76 0.76 0.76 titanium dioxide-0.50 0.50Triclosan 0.30 0.30 0.30 water adds to 100.00 and adds to 100.00 and add to 100.00
Compare with the dentifrice of corresponding no Gantrez polycarboxylate, above-mentioned dentifrice more effectively is discharged into triclosan in the soft tissue area of tooth and dental bed.
Example 9
Prepare following dentifrice:
Component glycerine 22.00 10.00 sorbierite (70%)-17.00 sodium carboxymethylcelluloses 1.00 1.00Gantrez S-97 2.00 2.00 saccharin sodiums 0.20 0.20 Sodium Benzoate 0.50 0.50 sodium monofluorophosphate 0.76 0.76 Tri-Compress 48.76 48.76Triclosan 0.30 0.30 lauryl sodium sulfate 1.20 1.20 flavor enhancements 0.89 0.89 water adds to 100.00 and adds to 100.00
Compare with the dentifrice of corresponding no Gantrez polycarboxylate, above-mentioned dentifrice more effectively is discharged into Triclosan in the hydroxyapatite dish of saliva coated.
Example 10
Prepare following speckle dentifrice against corrosion:
Component
Glycerol 15.00
Propylene glycol 2.00
Sodium carboxymethyl cellulose 1.50
Water 24.93
Vinyl methyl ether/maleic anhydride copolymers 4.76
(42% solution)
Sodium monofluorophosphate 0.76
Saccharin sodium 0.30
Insoluble Polymeric sodium metaphosphate. 47.00
Titanium dioxide 0.50
Sodium lauryl sulphate 2.00
Triclosan 0.30
Flavoring agent 0.95
In above-mentioned example, make still can reach after some is replaced the result of improvement, available phenol, 2,2 '-di-2-ethylhexylphosphine oxide (4-chloro-6-bromophenol), acetaminol, the some replacement Triclosan in the thymol; And/or replace Gantrez as with carbopol (Carbopols) (for example 934) with other AEA.Or the styryl phosphonic acid polymer of molecular weight in 3,000 to 10,000 scopes, as poly-(β-styryl phosphonic acid); The copolymer of vinylphosphonic acid and β-styryl phosphonic acid, and poly-(α-styryl phosphonic acid) or sulfo-acrylated oligomer, or 1: 1 copolymer of maleic anhydride and ethyl acrylate.
Example 11
The dentifrice mobile phase composition that contains Triclosan ... component %W/W
A B sorbierite (70%) 53.33 40.00 water 40.48 39.15Gantrez S (15%)----13.33NaOH (50%) 1.33 asccharin 0.40 0.40 sodium fluoride 1.47 1.47 lauryl sodium sulfate, 3.33 3.33Triclosan 0.67 0.67 of 0.32 0.32 flavored oils
The concentration of above-mentioned composition is the concentration of 1.33% dentifrice, has reflected the abradant of 25% concentration, will use this abradant when constituting complete dentifrice.
Test the absorbing state of Triclosan on the HA of saliva coated dish in the dentifrice mobile phase of above-mentioned specified mix, the results are shown in following table:
Table
The hydroxyapatite dish of saliva coated absorbs Triclosan from dilution and undiluted dentifrice mobile phase.
The absorption (ug/ dish) 55 122 of A B%Triclosan 0.67 0.67 ionic strength (M/L) (value of calculation) 0.375----PH 8.7 7.6Triclosan
Undiluted
The above results shows, contains the absorption value of Triclosan in the B prescription of Gantrez, will increase 2 times than the value of the A prescription that does not contain Gantrez and have a surplus.
Example 12
From then on the concentration of Triclosan and HA absorb the value of Triclosan in the supernatant in the clear liquid of 1: 1 dentifrice/aqueous slurry.Dentifrice concentration (ug/ml) pg/ that contains the absorption value sodium of Triclosan2.5% lauryl sulphate acid Triclosan in 1: 1 serosity supernatant of 0.5%Triclosan coils 25% hydration Silicon stone+1.5% 1,650 52Gantrez S-9750% aluminium oxide+1.5%Gantrez S-97 1,905 74 supernatant with 1: 1 dentifrice/aqueous slurry of above-mentioned dentifrice are made the mensuration of the HA dish of triclo-san concentration and saliva coated to the triclosan absorption value.The result shows, under 1: 1 diluting condition, has increased the actual amount (rising to 1,905 from 1,650) of Triclosan with 50% alumina abrasive, and has caused the substantial increase of triclosan absorption value (rising to 74 from 52).
Example 13
Following collutory has reduced plaque by increasing triclosan effectively in the absorption of oral surfaces and reservation.
Component
A B C D EGantrez S-97 0.24 0.25 0.25 0.25 0.25 glycerine 15.00 10.00 15.00 10.00 15.00 ethanol--12.50 12.50-propane diols-5.00-, 5.00-Pluronic F108-2.00 (polyoxyethylene/polyoxypropylene block copolymer) lauryl sodium sulfate--0.20 0.20 0.20Triclosan, 0.10 0.10 0.06 0.06 0.03 flavored oils 0.40 0.40 0.40 0.40 0.40 water all adds to 100.00
Following liquid dentifrice also can reduce plaque effectively by increasing the absorption and the reservation of triclosan at oral surfaces:
Component
Contain mannose in A B C glycerine 20.0 20.0-Gantrez S-97 0.3 0.3 0.3 high molecular weight polysaccharide molecules; Glucose; Glucuronic acid potassium and acetyl group part, approximate mole ratio are 2: 1: 1: insoluble sodium metaphosphate 10.0-10.0 anhydrous dicalcium phosphates of 1 0.8-1.0 Sodium Benzoates, 0.5 0.5 0.5 saccharin sodium 0.5 0.5 0.5 water, 61.3 73.1 71.6 lauryl sodium sulfate 3.0 3.0 3.0 1.0-2.5 flavored oils 2.5 2.5 2.5 ethanol--10.0Triclosan 0.1 0.1 0.1
In above-mentioned example, make still can reach after some is replaced the result of improvement, use phenol, 2,2 '-di-2-ethylhexylphosphine oxide (4-chloro-6-bromophenol), acetaminol, some replacement Triclosan in the thymol, and/or, replace Gantrez with other AEA, as carbopol (Carbopols) (for example 934) or styryl phosphonic acid polymer (molecular weight 3,000~10,000) as poly-(β-styryl phosphonic acid), the copolymer of vinylphosphonic acid and β-styryl phosphonic acid, and poly-(α-styryl phosphonic acid), or the sulfo-acrylic acid oligomer, or maleic anhydride and 1: 1 copolymer of ethyl acrylate.
In the present invention, to some preferably instantiation be described.To the skilled expert of art technology is conspicuous modification and improvement, also will be included in the scope of present patent application and in the affiliated claim scope.
Claims (27)
1. dentifrice, its contain in mouth with the aqueous excipient that cleans one's teeth in effective speckle dosage against corrosion be 0.01-5wt% and be selected from halogenated diphenyl ether, halo N-N-phenylsalicylamide, benzoate, the water-insoluble non-cationic antimicrobial agent of halo carbanilide and phenol compound and the antimicrobial enhancing agent of 0.005-4wt.%, described antimicrobial enhancing agent are to contain one to discharge the polymer that strengthens a group and an organic reservation enhancing group, wherein discharge the enhancing group and are tart and are selected from carboxylic acid, phosphonic acids, hypophosphorous acid, sulfonic acid, their salt, organic reservation strengthens group and has comprised general formula O (X) n-R, wherein X is O, N, S, SO, SO
2, P, PO or Si; R is a hydrophobic alkyl, alkenyl, acyl group; aryl, alkaryl, aralkyl; heterocyclic radical or their inert substitutive derivative; n is 1 or zero, and these groups can discharge described antibacterial and be retained in tooth and dental bed surface, and the acceptable excipient of mouth; this excipient can make the antibacterial of speckle effective dose against corrosion be dissolved in saliva effectively, and described dentifrice has been removed the condensed phosphate of effective calculus amount from.
2. the dentifrice in the claim 1, wherein said dentifrice contains the siliceous buffing compound of 5-30wt.% in described excipient, the described antibacterial of 0.25-0.35wt.%, exist at least a (a) 0.5-5wt.% to be selected from anion in the described excipient, the surfactant of nonionic and amphoteric surfactant and (b) flavored oils of 0.1-5wt.%, described flavored oils is selected from Oleum Menthae Rotundifoliae, Oleum menthae, wintergreen oil, Sassafras oil, Oleum Caryophylli, sage oil, Eucalyptus oil, Herba Origani oil, Oleum Cinnamomi, Fructus Citri Limoniae oil, citrus seed oil and methyl salicylate.
3. the dentifrice in the claim 1, wherein said dentifrice also contains a kind of solubilising material, wherein the amount of solubilizing agent is 0.5-20wt.%, it is from propylene glycol, dipropylene glycol, hexanediol, methyl cellosolve, ethyl cellosolve, vegetable oil and the wax and the pentyl acetate that contain at least 12 carbon atoms are selected in ethyl acetate and the benzyl benzoate.
4. the dentifrice in the claim 3, the amount of wherein said antibacterial is 0.25-0.5wt.%.
5. the dentifrice in the claim 3, the amount of wherein said antibacterial is 0.35wt.%-5wt.%.
6. the dentifrice of claim 5, the amount of wherein said antibacterial is 0.35wt.%-0.5wt.%.
7. the dentifrice in the claim 1, wherein said dentifrice contains acceptable water-insoluble buffing compound on the 30-75wt% dentistry.
8. the dentifrice in the claim 1, wherein said dentifrice is collutory or liquid teeth cleaning agent, described mouthful is aqueous excipient with acceptable excipient, in this excipient, there is a kind of anion that is selected from least, the surfactant of nonionic or amphoteric surfactant, a kind of Oleum Menthae Rotundifoliae that is selected from, Oleum menthae, wintergreen oil, Sassafras oil, Oleum Caryophylli, sage oil, Eucalyptus oil, Herba Origani oil, Oleum Cinnamomi, Fructus Citri Limoniae oil, the flavored oils of citrus seed oil and methyl salicylate is selected from the avirulence alcohol of ethanol and isopropyl alcohol, and wherein the weight ratio of water and alcohol is 1 in the aqueous excipient: 1-20: 1.
9. the arbitrary dentifrice among the claim 1-8, wherein, the content of surfactant is 0.5-5wt.%.
10. the arbitrary dentifrice among the claim 1-8, wherein the content of flavored oils is 0.1%-5wt.%.
11. the dentifrice in the claim 8; wherein said dentifrice is a liquid teeth cleaning agent; it contains 0.3-2.0wt.% and molecular weight surpasses 1; 000,000 polysaccharide as suspending agent and thickening agent, this polysaccharide contains mannose; glucose; glucuronic acid potassium and Acetyl Groups part, their ratio are 2: 1: 1: 1, and this liquid teeth cleaning agent also contains the polishing material of 10-20wt.%.
12. the arbitrary dentifrice among the claim 1-8, wherein said antibacterial is a halogenated diphenyl ether.
13. the dentifrice in the claim 12, wherein said halogenated diphenyl ether be 2,4,4 '-three chloro-2 '-hydroxy diphenyl ether.
14. the dentifrice in the claim 3, wherein solubilizing agent is a propylene glycol, and its amount is 0.5wt.%.
15. the dentifrice in the claim 7, wherein buffing compound is from Polymeric sodium metaphosphate., tricalcium phosphate, and Tri-Compress, anhydrous dicalcium phosphate, calcium carbonate, aluminium silicate, hydrated alumina, silicon dioxide is selected in Bentonite and their mixture.
16. the dentifrice in the claim 15, wherein said buffing compound are Tri-Compress or hydrated alumina.
17. the dentifrice in the claim 1, the mean molecule quantity of wherein said antimicrobial enhancing agent are 100-1,000,000.
18. the dentifrice in the claim 17, wherein said antimicrobial enhancing agent are an anionic polymer, this polymer contains described release to be strengthened group and keeps the enhancing group.
19. the dentifrice in the claim 18, wherein said anionic polymer comprise one and contains the chain that repeats to form unit, each repeats to form unit and contains a carbon atom at least.
20. the dentifrice in the claim 19, wherein each recurring unit contains at least one and discharge to strengthen group and one and keep and strengthen group, and atom links to each other in adjacent mode in these groups and the recurring unit.
21. the dentifrice in the claim 1, wherein discharging the enhancing group is carboxyl.
22. the dentifrice in the claim 21, wherein antimicrobial enhancing agent is the copolymer of maleic acid or anhydride and the undersaturated polymerisable monomer of another kind of inert ethylene linkage.
23. the dentifrice in the claim 22, other monomer of wherein said copolymer is a methyl vinyl ether, and with maleic acid or anhydride with 4: 1-1: 4 mol ratio polymerizations.
24. the dentifrice in the claim 23, the molecular weight of wherein said copolymer are 30,000-1, and 000,000, and exist with 0.1-3wt.%.
25. the dentifrice in the claim 24, wherein the mean molecule quantity of copolymer is 70,000.
26. the dentifrice in the claim 1, wherein discharging the enhancing group is phosphonyl group or its salt.
27. the dentifrice in the claim 26, wherein antimicrobial enhancing agent is poly-(β-styryl phosphonic acid) polymer, or any styryl phosphonic acid and the undersaturated monomeric copolymer of another kind of ethylene linkage.
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/291,712 US4894220A (en) | 1987-01-30 | 1988-12-29 | Antibacterial antiplaque oral composition |
US291,712 | 1988-12-29 | ||
US39966989A | 1989-08-25 | 1989-08-25 | |
US39860689A | 1989-08-25 | 1989-08-25 | |
US39860589A | 1989-08-25 | 1989-08-25 | |
US398,592 | 1989-08-25 | ||
US398,606 | 1989-08-25 | ||
US399,669 | 1989-08-25 | ||
US07/398,592 US5188821A (en) | 1987-01-30 | 1989-08-25 | Antibacterial antiplaque oral composition mouthwash or liquid dentifrice |
US398,566 | 1989-08-25 | ||
US07/398,566 US5032386A (en) | 1988-12-29 | 1989-08-25 | Antiplaque antibacterial oral composition |
US398,605 | 1989-08-25 | ||
US41068289A | 1989-09-21 | 1989-09-21 | |
US410,682 | 1989-09-21 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN93102570A Division CN1054504C (en) | 1993-03-15 | 1993-03-15 | Antibacterial antiplaque oral composition |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1044047A CN1044047A (en) | 1990-07-25 |
CN1048867C true CN1048867C (en) | 2000-02-02 |
Family
ID=27569612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN89109648A Expired - Fee Related CN1048867C (en) | 1988-12-29 | 1989-12-28 | Antiplaque antibacterial oral composition |
Country Status (31)
Country | Link |
---|---|
JP (1) | JP2708134B2 (en) |
CN (1) | CN1048867C (en) |
AT (1) | AT397765B (en) |
AU (1) | AU625379B2 (en) |
BR (1) | BR8906866A (en) |
CH (1) | CH679639A5 (en) |
DE (1) | DE3942643B4 (en) |
DK (1) | DK175071B1 (en) |
DZ (2) | DZ1382A1 (en) |
FI (1) | FI100691B (en) |
FR (2) | FR2641186B1 (en) |
GB (3) | GB2227660B (en) |
GR (1) | GR1004463B (en) |
HK (3) | HK154796A (en) |
HU (1) | HU212183B (en) |
IE (1) | IE65326B1 (en) |
IL (1) | IL92692A0 (en) |
IT (1) | IT1237483B (en) |
LU (1) | LU87650A1 (en) |
MA (1) | MA21712A1 (en) |
MX (1) | MX173741B (en) |
MY (1) | MY105879A (en) |
NL (1) | NL194716C (en) |
NO (1) | NO179503C (en) |
NZ (1) | NZ231813A (en) |
OA (1) | OA09253A (en) |
PL (1) | PL165470B1 (en) |
PT (1) | PT92734B (en) |
SE (2) | SE507731C2 (en) |
SK (1) | SK280567B6 (en) |
ZW (1) | ZW17289A1 (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5256401A (en) * | 1987-01-30 | 1993-10-26 | Colgate-Palmolive Company | Antibacterial antiplaque mouthwash composition |
US5334375A (en) * | 1988-12-29 | 1994-08-02 | Colgate Palmolive Company | Antibacterial antiplaque oral composition |
SE512333C2 (en) * | 1989-08-25 | 2000-02-28 | Colgate Palmolive Co | Antibacterial oral composition with plaque- and tartar-limiting action |
IL92693A0 (en) * | 1989-08-25 | 1990-09-17 | Colgate Palmolive Co | Antibacterial antiplaque composition containing novel styrene-phosphonic acid copolymer |
AU9179791A (en) * | 1990-12-19 | 1992-07-22 | Procter & Gamble Company, The | Oral compositions effective against plaque and gingivitis |
US5094844A (en) * | 1990-12-20 | 1992-03-10 | Colgate-Palmolive Company | Anticalculus oral composition |
US5385729A (en) * | 1991-08-01 | 1995-01-31 | Colgate Palmolive Company | Viscoelastic personal care composition |
US5252313A (en) * | 1991-12-20 | 1993-10-12 | Colgate-Palmolive Company | Visually clear gel dentifrice |
US5192533A (en) * | 1992-03-25 | 1993-03-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Nonirritating antitartar and antiplaque oral compositions |
NZ247712A (en) * | 1992-06-19 | 1995-04-27 | Colgate Palmolive Co | Oral composition comprising an anti-bacterial compound, a water-insoluble biodegradable polymer, and an organic solvent |
WO1995017879A1 (en) * | 1993-12-29 | 1995-07-06 | The Procter & Gamble Company | Tartar control dentifrice composition containing thymol |
US5462728A (en) * | 1994-04-05 | 1995-10-31 | Blank; Izhak | Pharmaceutical compositions |
JP3494739B2 (en) * | 1995-02-13 | 2004-02-09 | 株式会社ジーシー | Tooth surface treatment agent for dental glass ionomer cement |
WO1999032074A2 (en) * | 1997-12-18 | 1999-07-01 | Unilever N.V. | Oral care composition |
KR100384103B1 (en) * | 1998-04-02 | 2003-10-08 | 주식회사 태평양 | An oral composition containing triclosan |
US6241972B1 (en) * | 1999-02-19 | 2001-06-05 | Block Drug Company, Inc. | Oral care formulation for the treatment of sensitivity teeth |
DE10051955A1 (en) * | 2000-10-20 | 2002-05-02 | Wella Ag | Hair treatment agent in the form of a solid and dimensionally stable gel |
WO2002047638A1 (en) | 2000-12-15 | 2002-06-20 | Unilever N.V. | Oral bleaching composition |
WO2002055043A1 (en) | 2001-01-16 | 2002-07-18 | Unilever N.V. | Oral composition |
CN100579998C (en) * | 2001-07-13 | 2010-01-13 | 花王株式会社 | Oral-use polymer and oral-use composition |
US6912826B2 (en) | 2002-10-07 | 2005-07-05 | Zoran Momich | Carrier loading cartoner |
US7846422B2 (en) | 2003-08-04 | 2010-12-07 | Kao Corporation | Method for prevention or treatment of periodontal diseases and composition for an oral cavity |
US20060024245A1 (en) * | 2004-07-29 | 2006-02-02 | Cadbury Adams, Llc. | Tooth whitening compositions and delivery systems therefor |
US8974772B2 (en) | 2004-12-28 | 2015-03-10 | Colgate-Palmolive Company | Two phase toothpaste composition |
WO2009099451A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Arginine salts and their uses for the treatment of illnesses in the oral cavity |
JP2012522777A (en) * | 2009-04-02 | 2012-09-27 | コルゲート・パーモリブ・カンパニー | Dentifrice composition |
CN102470079B (en) | 2009-08-19 | 2014-07-02 | 荷兰联合利华有限公司 | Delivery system |
WO2011109919A1 (en) | 2010-03-09 | 2011-09-15 | Unilever Plc | Stable oral care compositions |
RU2533220C2 (en) * | 2010-07-29 | 2014-11-20 | Колгейт-Палмолив Компани | Phosphate-free oral care compositions with antibacterial agent of magnolia |
CN103079526A (en) | 2010-09-10 | 2013-05-01 | 荷兰联合利华有限公司 | Oral care compositions for benefiting teeth |
CN107308010A (en) | 2010-09-10 | 2017-11-03 | 荷兰联合利华有限公司 | Composite particles active matter and its manufacture method |
TR201802434T4 (en) | 2011-04-18 | 2018-03-21 | Unilever Nv | Oral care compositions for remineralization of teeth. |
US20180125625A1 (en) | 2015-06-05 | 2018-05-10 | Conopco, Inc., D/B/A Unilever | Oral care device |
EP3302349B1 (en) | 2015-06-05 | 2019-11-20 | Unilever PLC | Oral care device |
WO2016192925A1 (en) | 2015-06-05 | 2016-12-08 | Unilever Plc | Oral care device |
EP3222326A1 (en) | 2016-03-23 | 2017-09-27 | Unilever PLC | Toothpaste composition |
EP3295921A1 (en) | 2016-09-14 | 2018-03-21 | Unilever PLC | Use of oral care composition |
GB201811065D0 (en) * | 2018-07-05 | 2018-08-22 | GlaxoSmithKline Consumer Healthcare UK IP Ltd | Novel composition |
WO2020052855A1 (en) | 2018-09-12 | 2020-03-19 | Unilever Plc | Oral care composition |
WO2020212159A1 (en) | 2019-04-17 | 2020-10-22 | Unilever Plc | Oral care product |
EP3888621A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care device |
EP3888623A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care system |
EP3888619A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care device |
EP3888622A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care system |
EP3888620A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care system |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3629477A (en) * | 1966-08-08 | 1971-12-21 | Geigy Chem Corp | Halogenated diphenyether-containing compositions and control of pests therewith |
US4022880A (en) * | 1973-09-26 | 1977-05-10 | Lever Brothers Company | Anticalculus composition |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3429963A (en) * | 1964-06-09 | 1969-02-25 | Colgate Palmolive Co | Dental preparation containing polymeric polyelectrolyte |
ZA717486B (en) * | 1970-11-19 | 1973-06-27 | Colgate Palmolive Co | Treatment of teeth |
US3897548A (en) * | 1973-04-09 | 1975-07-29 | Indiana University Foundation | Oral compositions for retarding the formation of dental plaque and methods of utilization thereof |
US4138477A (en) * | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
US4342857A (en) * | 1980-12-31 | 1982-08-03 | Colgate-Palmolive Company | Antigingivitis composition comprising vinyl phosphonic acid/vinyl phosphonyl fluoride copolymer |
JPS5988416A (en) * | 1982-11-15 | 1984-05-22 | ジヨンソン・エンド・ジヨンソン・プロダクツ・インコ−ポレ−テツド | Oral sanitary composition |
DE3445695A1 (en) * | 1983-12-28 | 1985-07-11 | Colgate-Palmolive Co., New York, N.Y. | AGENT FOR ORAL-DENTAL APPLICATION AGAINST PLAQUE AND GINGIVITIS |
GB8411841D0 (en) * | 1984-05-09 | 1984-06-13 | Unilever Plc | Oral compositions |
GB8526093D0 (en) * | 1985-10-22 | 1985-11-27 | Beecham Group Plc | Composition |
GB8615534D0 (en) * | 1986-06-25 | 1986-07-30 | Beecham Group Plc | Composition |
JPH0772125B2 (en) * | 1986-08-29 | 1995-08-02 | ライオン株式会社 | Oral composition |
IN168400B (en) * | 1987-01-30 | 1991-03-23 | Colgate Palmolive Co | |
SE8904179L (en) * | 1988-12-29 | 1990-06-30 | Colgate Palmolive Co | PRE-PACKED ORAL ANTI-PLAQUE COMPOSITIONS |
SE512333C2 (en) * | 1989-08-25 | 2000-02-28 | Colgate Palmolive Co | Antibacterial oral composition with plaque- and tartar-limiting action |
-
1989
- 1989-12-12 SE SE8904180A patent/SE507731C2/en unknown
- 1989-12-13 IL IL92692A patent/IL92692A0/en not_active IP Right Cessation
- 1989-12-13 AU AU46769/89A patent/AU625379B2/en not_active Expired
- 1989-12-15 NZ NZ231813A patent/NZ231813A/en unknown
- 1989-12-20 MX MX018805A patent/MX173741B/en unknown
- 1989-12-21 ZW ZW172/89A patent/ZW17289A1/en unknown
- 1989-12-21 GR GR890100853A patent/GR1004463B/en not_active IP Right Cessation
- 1989-12-21 GB GB8928878A patent/GB2227660B/en not_active Expired - Lifetime
- 1989-12-22 IT IT04869489A patent/IT1237483B/en active IP Right Grant
- 1989-12-22 DE DE3942643A patent/DE3942643B4/en not_active Expired - Lifetime
- 1989-12-25 DZ DZ890197A patent/DZ1382A1/en active
- 1989-12-26 MA MA21974A patent/MA21712A1/en unknown
- 1989-12-27 CH CH4685/89A patent/CH679639A5/de not_active IP Right Cessation
- 1989-12-27 MY MYPI89001861A patent/MY105879A/en unknown
- 1989-12-27 PT PT92734A patent/PT92734B/en not_active IP Right Cessation
- 1989-12-28 FI FI896316A patent/FI100691B/en active IP Right Grant
- 1989-12-28 HU HU896808A patent/HU212183B/en unknown
- 1989-12-28 CN CN89109648A patent/CN1048867C/en not_active Expired - Fee Related
- 1989-12-28 SK SK7512-89A patent/SK280567B6/en not_active IP Right Cessation
- 1989-12-28 NO NO895310A patent/NO179503C/en not_active IP Right Cessation
- 1989-12-28 FR FR8917373A patent/FR2641186B1/en not_active Expired - Lifetime
- 1989-12-28 DK DK198906709A patent/DK175071B1/en not_active IP Right Cessation
- 1989-12-28 IE IE419589A patent/IE65326B1/en not_active IP Right Cessation
- 1989-12-29 LU LU87650A patent/LU87650A1/en unknown
- 1989-12-29 PL PL89283117A patent/PL165470B1/en unknown
- 1989-12-29 BR BR898906866A patent/BR8906866A/en not_active Application Discontinuation
- 1989-12-29 OA OA59716A patent/OA09253A/en unknown
- 1989-12-29 AT AT0296889A patent/AT397765B/en not_active IP Right Cessation
- 1989-12-29 NL NL8903187A patent/NL194716C/en not_active IP Right Cessation
-
1990
- 1990-01-04 JP JP2000211A patent/JP2708134B2/en not_active Expired - Lifetime
-
1992
- 1992-08-07 GB GB9216778A patent/GB2257362B/en not_active Expired - Lifetime
- 1992-10-13 FR FR9212240A patent/FR2681529B1/en not_active Expired - Lifetime
- 1992-12-03 GB GB9225278A patent/GB2259856B/en not_active Expired - Lifetime
-
1993
- 1993-06-23 DZ DZ930077A patent/DZ1699A1/en active
-
1996
- 1996-08-15 HK HK154796A patent/HK154796A/en not_active IP Right Cessation
- 1996-08-15 HK HK154996A patent/HK154996A/en not_active IP Right Cessation
- 1996-08-15 HK HK154896A patent/HK154896A/en not_active IP Right Cessation
-
1997
- 1997-10-09 SE SE9703681A patent/SE510832C2/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3629477A (en) * | 1966-08-08 | 1971-12-21 | Geigy Chem Corp | Halogenated diphenyether-containing compositions and control of pests therewith |
US4022880A (en) * | 1973-09-26 | 1977-05-10 | Lever Brothers Company | Anticalculus composition |
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