CN1245985C - Compositions containing ascorbic acid phosphoric acid esters - Google Patents
Compositions containing ascorbic acid phosphoric acid esters Download PDFInfo
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- CN1245985C CN1245985C CNB018132413A CN01813241A CN1245985C CN 1245985 C CN1245985 C CN 1245985C CN B018132413 A CNB018132413 A CN B018132413A CN 01813241 A CN01813241 A CN 01813241A CN 1245985 C CN1245985 C CN 1245985C
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- ascorbic acid
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- phosphoric acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
Compositions containing ascorbic acid phosphoric acid esters characterized by containing: (A) an ascorbic acid phosphoric acid ester or its salt; (B) an anionic surfactant; and (C) one or more sugar alcohols selected from among monosaccharide alcohols having 4 or more carbon atoms, oligosaccharide alcohols and reducing starch syrups; having less than 10% by weight, based on the whole composition, of calcium and aluminum ion sources, and showing a pH value of 8.0 or higher after storing at 25 DEG C for 1 month.
Description
Technical field
The present invention relates to a kind of oral and topical composition that contains ascorbic acid phosphoric acid esters.
Background technology
Known ascorbic acid phosphoric acid esters and salt thereof have important function in the enzymatic activity in the exploitation body, and have multiple physiologically active.Especially, admit: they serve as a kind of coenzyme of prolyl and lysyl hydroxylase, and synthetic for collagen be essential.In recent years, pay close attention to a kind of ester or salt of antioxidant vitamin, this vitamin can be removed the excessive active oxygen that is produced in the body always, and can prevent the imbalance of living tissue oxygen.And known these esters and salt have multiple physiologically active.
Up to now, propose a large amount of compositionss that contains ascorbic acid phosphoric acid esters and salt thereof, comprised cosmetics (Japan Patent discloses Sho 62-298508 number and Japan Patent discloses Hei3-63208 number), whitening cosmetic (Japan Patent disclose Sho 63-243014 and Japanese patent application publication No. Hei 1-305009 number and 3-133914 number), buccal (Japan Patent discloses Sho 62-96408 number), bathe agent (Japan Patent discloses Sho 62-96410 number), (Japan Patent discloses Hei 2-292210 to Orally administered composition, 2-292211 and 4-173727 number), (Japan Patent discloses Hei 3-34908 to the external preparation of skin, 7-206632 and 8-133951 number) or the like.
But when ascorbic acid phosphoric acid esters or its salt were formulated into dissimilar compositionss, because the influence of calcium, metal, microorganism and pH, they became unstable, and the problem of following appearance is that they are converted into ascorbic acid and phosphoric acid.Therefore, need to keep the stable of compositions.
In order to address this problem, in prescription, add antioxidant or chelating agen.And, for the touch controls of itself and water to minimum degree, carried out changing this compositions into powder or particulate research (open Hei7-252127 number of Japan Patent).But have in the compositions of ascorbic acid phosphoric acid esters and salt thereof in preparation, not only need to make the ascorbic acid phosphoric acid esters of being prepared stable, but also need make them in application, can reach higher physiological activities.
Aspect this, should select to have the preparation of applications well, such as paste, liquid or emulsifiable paste, so that it keeps suitable foaming capacity and dispersibility.Simultaneously, in these preparations, keep in the structure of ascorbic acid phosphoric acid esters and salt thereof this ester or salt being absorbed by applied live body.Need a kind of technology of exploitation at present, wherein in such aqueous compositions, can stably prepare a kind of ascorbic acid phosphoric acid esters or its salt to show this effectiveness.
Detailed description of the invention
The purpose of this invention is to provide ascorbic acid phosphoric acid esters and salt composition prepared thereof that a kind of usefulness is in stable and activated state.
In order to achieve the above object, the inventor has carried out deep research, found that, when with a kind of anion surfactant, be selected from the monosaccharide alcohol that contains 4 or 4 above carbon atoms with one or more, the sugar alcohol of the pure and mild reduction starch syrup of oligosaccharide, when being formulated in the compositions that contains ascorbic acid phosphoric acid esters or its salt, the content in calcium and aluminium ion source is limited in accounting for (being weight percentage at this below 10% of this total composition, down together), and its initial pH value is transferred to is not less than 8.0, be preferably 8.5 to 9.5, with this compositions 25 ℃ store down surpass one month after, contain the stability of the compositions of this ascorbic acid phosphoric acid esters, improve in time.In addition, long time stored after, can prevent effectively that the remaining rate of ascorbic acid phosphoric acid esters in this compositions or its salt from descending, to guarantee the performance of its effectiveness.Although its initial pH value transferred to 8.0 or more than, particularly 8.5 to 9.5, when many compositionss of having prepared ascorbic acid phosphoric acid esters or its salt were stored in the room temperature left and right sides after preparation, its pH value will change a lot in one month, and in some cases, pH value will become and be lower than 8.0.Its pH value is 8.0 or when following after 25 ℃ are down stored one month, can not obtain the stable ascorbic acid phosphoric acid esters and the preparation of salt thereof.Therefore, we have found that be important at the pH value of 25 ℃ of compositionss after storing month for the stable and activated state of the preparation of ascorbic acid phosphoric acid esters and salt thereof.
Brief description of drawings
[accompanying drawing 1]
Accompanying drawing 1 (A), 1 (B) and 1 (C) are respectively the sketch maps that shows labial teeth gingiva state, wherein accompanying drawing 1 (A) shows the state of not suffering from gingivitis, accompanying drawing 1 (B) shows the state suffer from the slight extent gingivitis, accompanying drawing 1 (C) but show the state of suffering from perception degree gingivitis.
Finish best mode of the present invention
Now the present invention is explained in more detail.
The feature of the present composition is to contain (A) ascorbic acid phosphoric acid esters or its salt, (B) anion surfactant and one or more sugar alcohols that (C) are selected from the pure and mild reduction starch syrup of monosaccharide alcohol, oligosaccharide that contains 4 or 4 above carbon atoms, wherein the content in calcium and aluminium ion source is less than 10% of total composition, and 25 ℃ store one month down after the pH value of this compositions be 8.0 or more than.
Ascorbic acid phosphoric acid esters refers to those esters, wherein in 2,3,5 and 6 of ascorbic acid arbitrarily the one or more hydroxyls on the position for example be phosphoric acid and polyphosphoric acid esterification by a kind of chemical compound.Example comprises ascorbic acid-2-phosphate ester, ascorbic acid-3-phosphate ester, ascorbic acid-6-phosphate ester, ascorbic acid-2-polyphosphate or the like.The salt of these esters comprises, for example is alkali metal salt and alkali salt, such as sodium salt, potassium salt, calcium salt, magnesium salt or the like.Certainly, be used for the compositions in oral cavity, from the angle of prevention and treatment periodontal, the magnesium salt and the sodium salt of preferred ascorbic acid phosphoric acid esters.
It is measured to account for 0.001 to 10% of total composition amount, and preferred 0.01 to 5%.If measure too for a short time, its effectiveness can not show satisfactorily.Bigger amount may reduce availability.
Secondly, the purpose of application anion surfactant is to make this compositions have the foaming capacity and the dispersibility of suitable degree.Although admit: add the stability that anion surfactant will reduce ascorbic acid phosphoric acid esters or its salt, but according to the present invention, if prepared anion surfactant, can by with this compositions 25 ℃ the pH value of this compositions remained on after storing one month 8.0 or more than, overcome this point, can successfully obtain a kind of stable ascorbic acid phosphoric acid esters or the preparation of its salt simultaneously.
Used in the present invention anion surfactant is known commonly used those of those of ordinary skills; comprise, for example alkyl sulfate; laureth sulfate; alpha-sulfo fatty acid ester; the alpha-alefinically sulphonic acid ester; alkyl or hydroxyalkyl ether carboxylate; N-acidylate taurine; N-acidylate glycine; N-acidylate aspartic acid; N-acidylate sarcosine; N-acidylate 1,3-propanedicarboxylic acid; MAP; the alkylamidoalkyl ether sulfate; alkyl (gathering) glycerol ether sulfate; alkyl (gathering) glycerin ether carboxylate; secondary amide type N-acylamino-hydrochlorate; the tartaric acid alkylamide; the malic acid alkylamide; the citric acid alkylamide; alkyl (gathering) glycerol sulfonate; single glycerol succinic acid ester or the like.Wherein, preferred alkyl sulfate.
Suitably select a kind of amount of anion surfactant, be generally and account for 0.1 to 10% of total composition, be preferably 0.5 to 3%.
Compositions of the present invention also should be prepared one or more and be selected from the composition that institute's carbon atoms is not less than 4 the pure and mild reduction starch syrup of monosaccharide alcohol, oligosaccharide.The example that contains the monosaccharide alcohol of 4 or 4 above carbon atoms comprises erithritol, xylitol, mannitol, Sorbitol, galactitol, iditol or the like.The example of oligosaccharide alcohol comprises maltose alcohol, lactose, palatinit, maltotriose alcohol (maltotriito1), Isomaltotriose alcohol (isomaltotriito1) or the like.The reduction starch syrup comprises, for example is the reduction starch syrup of a kind of reduction starch syrup of low saccharifying, a kind of high saccharifying, a kind of reduction maltose syrup or the like.These can be used separately, but perhaps two or more use in conjunction.
Although the amount of these sugar alcohols can account for 1 to 80% of total composition, preferred 5 to 60%, these sugar alcohols compare 0.5 or above ratio preparation, more preferably 0.5 to 2.0 ratio, most preferably 0.75 to 1.5 ratio with the amount of water in the compositions therewith.Can make ascorbic acid phosphoric acid esters or its salt more effectively bring into play its effectiveness like this.
Should be noted that: glycerol is a kind of monosaccharide alcohol with 3 carbon atoms, and it does not have above-mentioned a kind of like this effectiveness.
In the embodiment of this invention, the content in calcium ion source and aluminium ion source is less than 10% of total composition, preferably be not more than 1%, especially preferably be not more than 0.1%, the for example a kind of calcium containing compound in this calcium ion source and aluminium ion source, for example calcium hydrogen phosphate, tertiary calcium phosphate, calcium pyrophosphate or the like and a kind of aluminum contained compound, for example aluminium hydroxide or the like.More particularly preferably be, do not prepare these calcium containing compounds and aluminum contained compound.If calcium containing compound exists with bigger amount, ascorbic acid phosphoric acid esters or its salt and calcium reaction will form a kind of insoluble calcium salt.If aluminum contained compound exists with bigger amount, because the effect of aluminum will promote the decomposition of ascorbic acid phosphoric acid esters or its salt.In the content of calcium containing compound and a kind of aluminum contained compound is limited at 10% scope less than total composition content, will overcome above-mentioned shortcoming.
Compositions of the present invention can be used for multiple purpose, for example oral cavity and external purpose, and its preparation can be chosen as various dosage forms.Preferably this compositions is made a kind of paste, liquid and cream or the like.
According to the final purposes and the form of preparation, available known composition and above-mentioned component are further prepared compositions of the present invention together.For example, the composition for oral cavity that is provided can be a kind of dentifrice, for example toothpaste, liquid teeth cleaning agent or other 2 kinds of cream that gingival massage is used; A kind of surperficial liniment or collutory.In this dentifrice, can prepare grinding agent, binding agent, sweetener, fumet and various types of effective ingredient of usual amounts.
Preferred grinding agent comprises silica abrasive, for example silica gel, precipitated silica, aluminosilicate, silicon zirconates (zirconosilicate) (in conjunction with the silicon dioxide of titanium) or the like.Magnesium carbonate, soap clay, methyl polymethacrylates or the like also can be prepared.
The binding agent that can prepare comprises one or more carrageenin; Cellulose derivative, for example sodium carboxymethyl cellulose, methylcellulose, hydroxyethyl-cellulose or the like; Alginic acid derivant, for example sodium alginate, propanediol alginate or the like; Natural gum is xanthan gum, gellan gum, tranganth glue, karaya or the like for example; Composite adhesives, for example polyvinyl alcohol, sodium polyacrylate, carboxy vinyl polymer or the like; And inorganic bond, for example silica gel, propolis, laponite or the like.
If necessary, except that above-mentioned sugar alcohol, wetting agent also comprises glycerol, propylene glycol, Polyethylene Glycol or the like.The surfactant that can prepare, except that foregoing anion surfactant, also comprise non-ionic surface active agent, for example glyceryl laurate in the last of the ten Heavenly stems (decaglyceryllaurate), myristoyl diglycollic amide (myristoyl diethanolamide) or the like, and amphoteric surfactant betanin for example.
Fumet comprises menthol, anethole, carvone, acetaminol, positron decanol, citronellol, α-terpinol, eucalyptole, linalool, ethyl linalool, vanillin, thymol, Oleum menthae, Oleum Menthae Rotundifoliae, wintergreen oil, cloves oil, Eucalyptus oil or the like, they can prepare separately or two or more co-formulated.And, can prepare sweetener, for example saccharin sodium, perillartine, thaumatin (thaumatin) or the like.
In enforcement of the present invention, can also prepare one or more known effective ingredient, comprise cationic germicide, for example chlorhexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, decalinium chloride or the like; Phenolic compounds, for example triclosan, chamenol, biozole or the like; Enzyme, for example glucanase, mutanase (mutanase), lysozyme, amylase, protease, bacteriolysin, SOD or the like; The alkali metal Monofluorophosphate is sodium monofluorophosphate, MFP potassium or the like for example; Fluoride is sodium fluoride, stannous fluoride or the like for example; Tranexamic acid, episilon amino caproic acid, allantoin, dihydro Dihydrocholesterol, glycyrrhizic acid, glycyrrhetinic acid, Radix Glycyrrhizae phosphate, chlorophyll, sodium chloride, xylitol, zinc chloride, water-soluble inorganic phosphate compounds, vitamin A, vitamin(e) B group, vitamin E class and derivant thereof.
Should adjust the initial pH value of the present composition, so as 25 ℃ down store 1 month after, pH be 8.0 or more than, preferred 8.0 to 9.5, preferred especially 8.5 to 9.5.The pH value of regulation is not an initial value, but the reason of storing the pH value after 1 month is: for most compositions, pH value is under the situation of contiguous room temperature, and great changes will take place in back 1 month of preparation, and finally be stabilized.Therefore, the present inventor notices: the pH value after storing 1 month under 25 ℃ is important.
In this case, the variation of pH value is according to the preparation type of composition and difference.For example, when preparation silica gel, pH value is higher than 25 ℃ of pH value of storing down after 1 month, but when the preparation precipitated silica, situation is opposite, and pH value then descends.Thereby, so that the pH value after storing 1 month under 25 ℃ reaches a predetermined pH value,, initial pH value is set in the level that is higher or lower than the pH value of predetermined storage after 1 month in order to regulate initial pH according to the preparation of compositions.If necessary, adopt a kind of technology, wherein can determine initial pH value and the relation between the pH value of 25 ℃ of following storages after 1 month according to a trial test.Should be noted that: can regulate pH value by using a pH value regulator commonly used, for this purpose, usually sodium hydroxide or potassium hydroxide can be used, and a kind of water miscible citrate, phosphate, carbonate, bicarbonate etc. can be preferably used.
Can prepare the compositions that contains ascorbic acid phosphoric acid esters of the present invention with a kind of ascorbic acid phosphoric acid esters or its salt that is in stable and activated state, it still demonstrates after storing for a long time has effective effectiveness.
Embodiment
Experimental example, embodiment and comparing embodiment are described, and with special statement the present invention, but the present invention should not be considered to be limited among the following embodiment.
Experimental example
Preparation contains the dentifrice of following prescription.Use prepares 1 to 3 months dentifrice, and it is carried out the application test in a week, to observe the effect of improving of gingivitis.Say that more specifically the experimenter of 10 normal health respectively uses following every kind of dentifrice A and B more than one week, stops oral cavity cleaning then 2 days, self evaluation gingivitis state, and fill in an application form.Should be noted that: the use of different dentifrice be at interval one the week or more than.In the result of application form, observe the gums of the labial teeth upper jaw and lower jaw, and with following mode, with an expression, 1 (A) is to 1 (C) with reference to the accompanying drawings.The results are shown in the table 1.
0: do not have gingivitis (accompanying drawing 1 (A))
1: observe slight gingivitis (accompanying drawing 1 (B))
2: observe can the perception degree gingivitis (accompanying drawing 1 (C))
In the accompanying drawings, X represents tooth, and Y represents gingiva, and Z represents the site of gingivitis.
Dentifrice A dentifrice B
L-ascorbic acid-2-magnesium phosphorate 0.3% 0.3%
Precipitated silica 15% 15%
Propylene glycol 3.5% 3.5%
Carboxymethyl cellulose 1.5% 1.5%
Butyl p-hydroxybenzoate 0.1% 0.1%
Saccharin sodium 0.2% 0.2%
Fumet 1% 1%
Sodium lauryl sulphate 1.5% 1.5%
Titanium dioxide 0.5% 0.5%
Citric acid 0.1% 0.1%
70% sorbitol solution 50%-
85% glycerol-0%
Sodium hydroxide 0.3% 0.35%
Purified water surplus surplus
Amount to 100.0% 100.0%
PH value (initial) 8.93 8.96
PH value (25 ℃ store 1 month after) 8.58 8.60
Moisture (weight ratio) 0.76 0 with the sugar alcohol ratio
Table 1
| Estimate point | During on-test | The dentifrice test is after 10 days | Stop oral cavity cleaning after 2 days | |||||||
| The point | 2 | 1 | 0 | 2 | 1 | 0 | 2 | 1 | 0 | |
| Experimenter's quantity | Dentifrice A | 0 | 3 | 7 | 0 | 0 | 10 | 0 | 2 | 8 |
| Dentifrice B | 0 | 4 | 6 | 0 | 1 | 9 | 0 | 5 | 5 | |
Embodiment 1 to 5, comparing embodiment 1 to 4
Prepare dentifrice respectively, wherein prepare the component shown in the table 2 (silicon dioxide, Sorbitol or glycerol) according to the mode shown in the table 2 with following same recipe.At once and in storage under 25 ℃ after 1 month, 6 months and 18 months, measuring the pH value of every kind of gained dentifrice after the preparation respectively.In addition, to a kind ofly in 60 ℃ thermostatic chamber, preserve the dentifrice product more than 1 month, a kind of dentifrice product and a kind of remaining rate of preserving the magnesium L-ascorbyl-2-phosphate of the dentifrice product more than 18 months in 25 ℃ thermostatic chamber of preserving in 40 ℃ thermostatic chamber more than 6 months measured.The results are shown in the table 2.
Same recipe:
L-ascorbic acid-2-magnesium phosphorate 0.3%
Propylene glycol 3.5
Carboxymethyl cellulose 1.5
Butyl p-hydroxybenzoate 0.1
Saccharin sodium 0.2
Fumet 1
Sodium lauryl sulphate 1.5
Titanium dioxide 0.5
Citric acid 0.1
Sodium hydroxide an amount of (about 0.3%)
Silicon dioxide meter 2
Sorbitol table 2
Glycerol table 2
The purified water surplus
Amount to 100.0%
Table 2
| Project | Embodiment | Comparing embodiment | |||||||
| 1 | 1 | 3 | 4 | 5 | 1 | 2 | 3 | 4 | |
| The type of silicon dioxide | A | A | B | B | B | B | A | B | B |
| Silica volume | 11％ | 11％ | 11％ | 11％ | 11％ | 21％ | 11％ | 16％ | 16％ |
| Sorbitol amount (70%) | 50％ | 45％ | 50％ | 45％ | 20％ | 40％ | 50％ | - | 30％ |
| The ratio of sugar alcohol/water | 0.78 | 0.65 | 0.78 | 0.65 | 0.29 | 0.67 | 0.78 | 0 | 0.60 |
| Amounts of glycerol (85%) | - | - | - | - | 20％ | - | - | 40％ | - |
| Initial pH value | 7.68 | 8.11 | 8.91 | 8.80 | 8.88 | 8.40 | 7.11 | 8.81 | 7.65 |
| 25 ℃ of 1H values of storing down after 1 month | 8.25 | 8.78 | 8.62 | 8.53 | 8.56 | 7.65 | 7.80 | 8.46 | 7.42 |
| 25 ℃ of pH value of storing down after 6 months | 8.36 | 8.86 | 8.62 | 8.51 | 8.52 | 7.62 | 7.87 | 8.42 | 7.41 |
| 25 ℃ of pH value of storing down after 18 months | 8.48 | 8.90 | 8.60 | 8.49 | 8.51 | 7.63 | 7.91 | 8.40 | 7.44 |
| 25 ℃ of remaining rates of storing down after 18 months | 95.1％ | 96.5％ | 97.0％ | 95.4％ | 92.2％ | 88.2％ | 89.6％ | 77.6％ | 80.6％ |
| Estimate | ○ | ○ | ○ | ○ | △ | × | × | × | × |
Silicon dioxide type A: silica gel
Silicon dioxide type B: precipitated silica
Embodiment 6Toothpaste
Propylene glycol 5%
70% Sorbitol 50
Carrageenin 1.2
Saccharin sodium 0.2
Sodium lauryl sulphate 1.2
Ethylparaben 0.1
Ascorbic acid-2-magnesium phosphorate 0.2
Citric acid monohydrate 0.2
Silicon zirconates 18
Silicic acid anhydride (Tokuyama company) 3
Fumet 0.9
Sodium hydroxide is an amount of
The purified water surplus
Total amount 100%
Initial pH value 9.28
25 ℃ of pH value 8.80 of storing down after 1 month
Embodiment 7Toothpaste
PEG400 5%
70% Sorbitol 40
Xanthan gum 1.1
Xylitol 10
Sodium lauryl sulphate 0.9
Myristic acid diglycollic amide 0.9
Palmic acid 0.5
Ascorbic acid-2-phosphate ester sodium 1
Citric acid monohydrate 0.5
Ethylparaben 0.1
Aluminosilicate 20
Fumet 1
The purified water surplus
Amount to 100%
Initial pH value 8.71
25 ℃ of pH value 8.92 of storing down after 1 month
Embodiment 8Toothpaste
Propylene glycol 400 4%
Sorbitol solution (60%) 40
Carboxymethyl cellulose 2
Saccharin sodium 0.15
Sodium lauryl sulphate 1
Sodium lauroyl sarcosine 0.2
Sodium benzoate 0.5
Tranexamic acid 0.05
Ascorbic acid-2-magnesium phosphorate 0.05
Sodium tartrate 0.02
Silicon dioxide 20 in conjunction with titanium
Coking Silicon stone 1
Fumet 1
Sodium hydroxide is an amount of
The purified water surplus
Amount to 100%
Initial pH value 9.05
25 ℃ of pH value 8.61 of storing down after 1 month
Embodiment 9Toothpaste
Propylene glycol 5%
Sorbitol solution (60%) 60
Sodium alginate 3
Saccharin sodium 0.15
Sodium lauryl sulphate 1
Butyl p-hydroxybenzoate 0.5
Triclosan 0.1
Ascorbic acid-2-phosphate ester sodium 1
Sodium tripolyphosphate 1
Sodium myristate 0.2
Silica gel 20
Fumet 1
Sodium hydroxide is an amount of
The purified water surplus
Amount to 100%
Initial pH value 7.91
25 ℃ of pH value 8.58 of storing down after 1 month
Embodiment 10Toothpaste
Sodium polyacrylate 0.5%
Xanthan gum 0.5
Propylene glycol 5
70% sorbitol solution 50
Saccharin sodium 0.1
Sodium benzoate 0.3
Sodium lauryl sulphate 1.5
Tranexamic acid 0.1
Ascorbic acid-2-magnesium phosphorate 0.5
Triethanolamine 2.5
Tartaric acid 2
Dl-alpha-tocopherol 0.2
Softwood trees bark extract 0.05
Sodium fluoride 0.2
Silica gel 10
Precipitated silica 10
Fumet 1
Sodium carbonate is an amount of
The purified water surplus
Amount to 100%
Initial pH value 8.71
25 ℃ of pH value 8.68 of storing down after 1 month
Embodiment 11Collutory
Ethanol 10%
Glycerol 5
Sorbitol 5
Mannitol 3
Maltose alcohol (Maltitol) 3
Poly(ethylene oxide) (60) hardened castor oil 1.0
Sodium lauryl sulphate 0.1
Ascorbic acid-2-magnesium phosphorate 0.2
Tocopheryl acetate 0.05
Fumet 0.3
The purified water surplus
Total amount 100%
Initial pH value 8.44
25 ℃ of pH value 8.49 of storing down after 1 month
Embodiment 12The oral cavity paste
Spermol 20%
Squalane 5
P.O.E. (40) hardened castor oil 0.1
Xylitol 8
Sorbitan monooleate 1
Sodium lauryl sulphate 0.2
Glycyrrhizic acid 0.1
Saccharin sodium 0.6
Ascorbic acid phosphoric acid esters sodium 0.3
Citric acid 0.5
Silicic acid anhydride 3
Fumet 0.3
Potassium hydroxide is an amount of
The purified water surplus
Total amount 100%
Initial pH value 8.25
25 ℃ of pH value 8.38 of storing down after 1 month
Claims (3)
1. a compositions that contains ascorbic acid phosphoric acid esters is characterized in that containing: (A) ascorbic acid phosphoric acid esters or its salt; (B) anion surfactant; And (C) one or more are selected from and have 4 or the monosaccharide alcohol of more a plurality of carbon atoms or the sugar alcohol of oligosaccharide alcohol; (D) water; Wherein the content in calcium and aluminium ion source is less than 10 weight % of total composition, and 25 ℃ store 1 month down after, the pH value of said composition is 8.0 or higher.
2. according to the compositions of claim 1, one or more the wherein contained sugar alcohols and the weight ratio of water are not less than 0.5.
3. according to the compositions of claim 1 or 2, wherein said compositions is the form of cream, surperficial liniment or collutory that dentifrice, gingival massage uses.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000199213A JP4257479B2 (en) | 2000-06-30 | 2000-06-30 | Method for producing dentifrice composition containing ascorbic acid phosphate or salt thereof |
| JP199213/00 | 2000-06-30 | ||
| JP199213/2000 | 2000-06-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1443072A CN1443072A (en) | 2003-09-17 |
| CN1245985C true CN1245985C (en) | 2006-03-22 |
Family
ID=18697266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB018132413A Expired - Lifetime CN1245985C (en) | 2000-06-30 | 2001-03-27 | Compositions containing ascorbic acid phosphoric acid esters |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP4257479B2 (en) |
| CN (1) | CN1245985C (en) |
| AU (1) | AU2001242807A1 (en) |
| WO (1) | WO2002002124A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040002855A (en) * | 2001-01-24 | 2004-01-07 | 오라세우티칼, 엘엘씨 | Topical oral care compositions |
| JP2004035416A (en) * | 2002-06-28 | 2004-02-05 | Sangi Co Ltd | Improved 3ds home care agent and system for microbial removal of dental caries |
| CN1909879B (en) * | 2004-01-20 | 2010-11-24 | 株式会社高丝 | Cosmetic |
| CN101247834B (en) * | 2005-06-17 | 2013-10-30 | 生命健康科学公司 | Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
| JP5765225B2 (en) * | 2009-06-08 | 2015-08-19 | ライオン株式会社 | Oral composition |
| JP5526619B2 (en) * | 2009-06-25 | 2014-06-18 | ライオン株式会社 | Toothpaste composition |
| JP5999173B2 (en) * | 2012-03-07 | 2016-09-28 | ライオン株式会社 | Oral composition |
| CN105663015B (en) * | 2016-03-24 | 2018-06-29 | 广州健朗医用科技有限公司 | A kind of special bee glue tooth paste of pregnant and lying-in women and preparation method thereof |
| CN111759788A (en) * | 2020-07-27 | 2020-10-13 | 浙江爱尚日用品有限公司 | Toothpaste for preventing and treating dental ulcer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2973511B2 (en) * | 1990-11-06 | 1999-11-08 | ライオン株式会社 | Oral composition |
| JP2000351905A (en) * | 1999-04-05 | 2000-12-19 | Showa Denko Kk | Ascorbic acid derivative-containing composition |
-
2000
- 2000-06-30 JP JP2000199213A patent/JP4257479B2/en not_active Expired - Fee Related
-
2001
- 2001-03-27 CN CNB018132413A patent/CN1245985C/en not_active Expired - Lifetime
- 2001-03-27 AU AU2001242807A patent/AU2001242807A1/en not_active Abandoned
- 2001-03-27 WO PCT/JP2001/002466 patent/WO2002002124A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| JP4257479B2 (en) | 2009-04-22 |
| CN1443072A (en) | 2003-09-17 |
| JP2002020292A (en) | 2002-01-23 |
| WO2002002124A1 (en) | 2002-01-10 |
| AU2001242807A1 (en) | 2002-01-14 |
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