CN104873612A - Traditional Chinese medicine composition for preventing chemotherapeutic phlebitis - Google Patents
Traditional Chinese medicine composition for preventing chemotherapeutic phlebitis Download PDFInfo
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- CN104873612A CN104873612A CN201510305574.4A CN201510305574A CN104873612A CN 104873612 A CN104873612 A CN 104873612A CN 201510305574 A CN201510305574 A CN 201510305574A CN 104873612 A CN104873612 A CN 104873612A
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for preventing chemotherapeutic phlebitis. The traditional Chinese medicine composition is composed of seven medicines including golden cypress, radix angelicae, rhizoma atractylodis, radix puerariae, phryma leptostachya, lycopodium clavatum and liquorice. The traditional Chinese medicine composition has the advantages of reasonable prescription and easiness in preparation, has obvious treatment effects of clearing away heat and toxic materials, dispelling wind, eliminating dampness, dredging collaterals, relieving pain, dispelling pathogenic factors from muscles and invigorating splenic yang and is an effective medicine for preventing the chemotherapeutic phlebitis.
Description
Technical field
The invention belongs to medical art, be specifically related to the phlebitic Chinese medicine composition of a kind of Prophylactic chemotherapy.
Background technology
Intravenous chemotherapy is one of three large means for the treatment of malignant tumor, because the pH of most chemotherapeutics is low, concentration is high, osmotic pressure is high, zest intensity is large, and chemotherapeutics itself can produce directly infringement to histiocyte and increase Permeability of Capillary Wall, therefore phlebitis in various degree can be caused.Phlebitis refers to that the stimulation that vein blood vessel inwall is subject to Different factor occurs that inflammation changes, and there is vein local pain, redness, edema, vein inflammatory that is streak, that even occur scleroma in severe one local shows, difficulty is caused to nursing staff's venipuncture, affect the input of medicine, the serious treatment affecting patient.The chemical inflammatory of the blood vessel wall that chemical phlebitis mainly causes the stimulation of blood vessel due to chemicals, phlebitic chemotherapeutics is often caused to have vincristine, vinorelbine, amycin, epirubicin, daunorubicin, doxorubicin, paclitaxel, cyclophosphamide, fluorouracil etc., wherein being mainly foaminess chemotherapeutics (strong stimulation), is secondly zest chemotherapeutic.Can be there is phlebitis in various degree in the patient of 50% ~ 80% according to statistics.Current clinical conventional magnesium sulfate dressing illing skin, but curative effect is not good enough.The traditional Chinese medical science thinks that phlebitis is because heat, the stasis of blood, poison, expectorant are tied mutually, hinders caused by the venation, uses if suit the medicine to the illness, reasonable compatibility, can reach effective prevention, can the object for the treatment of both the principal and secondary aspects of a disease,, therefore develop the phlebitic Chinese medicine preparation of the more significant Prophylactic chemotherapy of effect and be significant.
Summary of the invention
In order to solve the problem, the present invention aims to provide phlebitic Chinese medicine composition of a kind of Prophylactic chemotherapy and preparation method thereof.
An object of the present invention is to provide the phlebitic Chinese medicine composition of a kind of Prophylactic chemotherapy.
Another object of the present invention is to provide the preparation method of the phlebitic Chinese medicine composition of a kind of Prophylactic chemotherapy.
The phlebitic Chinese medicine composition of Prophylactic chemotherapy of the present invention, its active ingredient is made up of the crude drug of following weight portion: Cortex Phellodendri 8-12g, Radix Angelicae Dahuricae 6-8g, Rhizoma Atractylodis 6-10g, Radix Puerariae 6-10g, Herba speranskiae tuberculatae 5-7g, Herba Lycopodii 3-5g, Radix Glycyrrhizae 5-7g.
Optimal technical scheme of the present invention is that Chinese medicine composition of the present invention is obtained by the crude drug of following weight portion: Cortex Phellodendri 10g, Radix Angelicae Dahuricae 7g, Rhizoma Atractylodis 8g, Radix Puerariae 8g, Herba speranskiae tuberculatae 6g, Herba Lycopodii 4g, Radix Glycyrrhizae 6g.
The phlebitic Chinese medicine composition of Prophylactic chemotherapy of the present invention can also contain pharmaceutically acceptable carrier, is prepared into conventional formulation, as spray, ointment, lotion, membrane or tincture, is preferably tincture.
The preparation method of the phlebitic Chinese medicine composition of Prophylactic chemotherapy of the present invention comprises following steps: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount water temperature leaching 1h, and decoct 2h, second time adds 6 times amount soak by water 1.5h, filters; When filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.25 ~ 1.30, slowly ethanol is added under stirring when being chilled to 40 DEG C, alcohol content is made to reach 75%v/v, leave standstill 24 hours, leaching supernatant, reclaim ethanol to without alcohol taste, be directly used as medicine to use or add appropriate amount of auxiliary materials through normal process steps and make clinical acceptable dosage form.
The present invention relatively and prior art, has following clear superiority:
Chinese medicine composition prescription of the present invention mainly develops according to the pathogenic characteristic of chemotherapeutic phlebitis, Cortex Phellodendri, Rhizoma Atractylodis heat-clearing and toxic substances removing in side, removing food stagnancy damp eliminating; The Radix Angelicae Dahuricae, Herba speranskiae tuberculatae, Herba Lycopodii fall apart wind dehumidifying, removing toxic substances pain relieving, relaxing muscles and tendons and activating QI and blood in the collateral, detumescence and apocenosis; Radix Puerariae expelling pathogenic factors from muscles for reducing heat yang invigorating; Radix Glycyrrhizae, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Full presciption medicine thing synergism, play special effect, play the effect of heat-clearing and toxic substances removing, loose wind damp eliminating, removing obstruction in the collateral to relieve pain, expelling pathogenic factors from muscles yang invigorating altogether, extremely strong specific aim prophylactic treatment effect is had to chemotherapeutic phlebitis, drug effect is definite, and clinical observation finds, observation group uses invention formulation Prophylactic chemotherapy phlebitis, there is not phlebitis rate 100%, be obviously better than matched group.
Further, in Chinese medicine composition of the present invention, the function of each crude drug and function cure mainly:
Cortex Phellodendri, bitter, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
The Radix Angelicae Dahuricae, pungent, temperature.Return stomach, large intestine, lung meridian.Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Rhizoma Atractylodis, pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.
Radix Puerariae, sweet, pungent, cool.Return spleen, stomach warp.Expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Herba speranskiae tuberculatae, pungent, bitter, temperature.Slightly poisonous.Return liver, kidney channel.Expelling wind and removing dampness, removing toxic substances pain relieving.For rheumatic arthritis; Sore swollen toxin is controlled in external.
Herba Lycopodii, micro-hardship, pungent, temperature.Return liver,spleen,kidney warp.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.
Radix Glycyrrhizae, sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 tincture
The each crude drug of the present invention is taken: Cortex Phellodendri 10g, Radix Angelicae Dahuricae 7g, Rhizoma Atractylodis 8g, Radix Puerariae 8g, Herba speranskiae tuberculatae 6g, Herba Lycopodii 4g, Radix Glycyrrhizae 6g by following weight portion.
Preparation technology is as follows: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount water temperature leaching 1h, and decoct 2h, second time adds 6 times amount soak by water 1.5h, filters; When filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.25 ~ 1.30, slowly adds ethanol, make alcohol content reach 75%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, is directly used as medicine to use or add appropriate amount of auxiliary materials through normal process steps and makes tincture.
When using Chinese medicine composition Prophylactic chemotherapy phlebitis of the present invention, use prepared tincture, every 100 milliliter contained amount 20g.
Embodiment 2 spray
The each crude drug of the present invention is taken: Cortex Phellodendri 8g, Radix Angelicae Dahuricae 6g, Rhizoma Atractylodis 6g, Radix Puerariae 6g, Herba speranskiae tuberculatae 5g, Herba Lycopodii 3g, Radix Glycyrrhizae 5g by following weight portion.
Preparation technology is as follows:
Take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount water temperature leaching 1h, and decoct 2h, second time adds 6 times amount soak by water 1.5h, filters; When filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.25 ~ 1.30, slowly adds ethanol, make alcohol content reach 75%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, is directly used as medicine to use or add appropriate amount of auxiliary materials through normal process steps and makes spray.
When using Chinese medicine composition Prophylactic chemotherapy phlebitis of the present invention, use prepared spray, every 100g is containing crude drug amount 20g.
Embodiment 3 ointment
The each crude drug of the present invention is taken: Cortex Phellodendri 12g, Radix Angelicae Dahuricae 8g, Rhizoma Atractylodis 10g, Radix Puerariae 10g, Herba speranskiae tuberculatae 7g, Herba Lycopodii 5g, Radix Glycyrrhizae 7g by following weight portion.
Preparation technology is as follows: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount water temperature leaching 1h, and decoct 2h, second time adds 6 times amount soak by water 1.5h, filters; When filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.25 ~ 1.30, slowly adds ethanol, make alcohol content reach 75%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, is directly used as medicine to use or add appropriate amount of auxiliary materials through normal process steps and makes ointment.
When using Chinese medicine composition Prophylactic chemotherapy phlebitis of the present invention, use prepared ointment, every 100 grams of ointment are containing crude drug amount 20g.
Embodiment 4 membrane
The each crude drug of the present invention is taken: Cortex Phellodendri 10g, Radix Angelicae Dahuricae 7g, Rhizoma Atractylodis 8g, Radix Puerariae 8g, Herba speranskiae tuberculatae 6g, Herba Lycopodii 4g, Radix Glycyrrhizae 6g by following weight portion.
Preparation technology is as follows: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount water temperature leaching 1h, and decoct 2h, second time adds 6 times amount soak by water 1.5h, filters; When filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.25 ~ 1.30, slowly adds ethanol, make alcohol content reach 75%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, is directly used as medicine to use or add appropriate amount of auxiliary materials through normal process steps and makes membrane.
When using Chinese medicine composition Prophylactic chemotherapy phlebitis of the present invention, use prepared membrane, every 100 grams contain crude drug amount 20g.
Embodiment 5 lotion
The each crude drug of the present invention is taken: Cortex Phellodendri 10g, Radix Angelicae Dahuricae 7g, Rhizoma Atractylodis 8g, Radix Puerariae 8g, Herba speranskiae tuberculatae 6g, Herba Lycopodii 4g, Radix Glycyrrhizae 6g by following weight portion.
Preparation technology is as follows: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount water temperature leaching 1h, and decoct 2h, second time adds 6 times amount soak by water 1.5h, filters; When filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.25 ~ 1.30, slowly adds ethanol, make alcohol content reach 75%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, is directly used as medicine to use or add appropriate amount of auxiliary materials through normal process steps and makes lotion.
When using Chinese medicine composition Prophylactic chemotherapy phlebitis of the present invention, use prepared lotion, every 100 grams contain crude drug amount 20g.
The phlebitic clinical observation of embodiment 6 Chinese medicine composition of the present invention Prophylactic chemotherapy
1, case-data:
Select institute of traditional Chinese medicine's outpatient service patients with lung cancer 88 example as object of study, pulmonary carcinoma Common Chemotherapy medicine has Erlotinib, Iressa, cisplatin, ifosfamide, amycin, etoposide, carboplatin, vincristine and methotrexate etc.Man 56 example, female 32 example in selected case, age 32-76 year, 51.94 ± 3.44 years old mean age.All patients are first chemotherapy, unconscious obstacle, and point of puncture local sensation is normal, and outward appearance is without redness, and blood vessel elasticity is good, without sclerosis.Get rid of the patient occurring severe complication at chemotherapeutic period and can not coordinate, intensive care unit person need be proceeded to as disturbance of consciousness, infection or the state of an illness obviously worsen.
The method of parallel control is adopted to be divided into observation group and matched group at random.The data of two groups of patients comprises sex, age, sick kind, blood vessel situation, site of puncture etc. compare, and there was no significant difference, P > 0.05, has comparability.
2, criterion:
According to the relevant phlebitis grade scale that venous transfusion association of the U.S. formulates, whether chemotherapeutic phlebitis is occurred to patient and the order of severity is assessed.This standard is divided into 5 grades:
1. 0 grade is without pain;
2. I grade, local skin is rubescent, companion's mild pain;
3. II grade, mild swelling, scorching hot, moderate pain;
4. III grade, local moderate swelling, severe pain, vesicle is formed, diameter≤1cm;
5. IV grade, middle severe swelling, intractable severe pain, vesicle diameter > 1cm, and affect limb function.
3, using method:
Observation group: moving towards 10cm, wide 5cm region along blood vessel above point of puncture 0.5cm, dips in the medicinal liquid soak of embodiment 1 preparation with absorbent cotton or gauze, until chemotherapeutics injection end is after 30 minutes, with normal saline flushing skin surface.
Matched group: moving towards 10cm, wide 5cm region along blood vessel above point of puncture 0.5cm, with by 3 layers of sterile gauze 50% magnesium sulfate apply soak in solution after external application, until chemotherapy treatment terminates after 30 minutes with normal saline flushing skin surface.
The phlebitis symptoms such as local redness, pain appear in rear observation in a week two groups of patients in medication process and after medication a situation arises.
4, observing effect:
Without exiting, without coming off case, all completing clinical observation in clinical observation process.
After the clinical observation treatment of a week, observation group: without 1 example, phlebitis occurs, phlebitis incidence rate is 0, and it is 100% that phlebitis rate does not occur.Matched group: phlebitis 0 grade of 28 example, I level is 8 examples, II grade of 5 example, III grade of 3 example, and IV grade of 0 example, phlebitis incidence rate 36.4%, it is 63.6% that phlebitis rate does not occur.Observation group's total effective rate is obviously better than matched group, and difference has statistical significance (P < 0.01).
Result display after above-mentioned clinical observation, Chinese herb on the prevention of the present invention is used to treat chemotherapeutic phlebitis, more effectively can reduce incidence rate and the order of severity thereof of chemotherapeutic phlebitis, compare with matched group and have significant difference, be worth studying and applying further.
Claims (6)
1. the phlebitic Chinese medicine composition of Prophylactic chemotherapy, is characterized in that, its crude drug primarily of following weight portion obtains: Cortex Phellodendri 8-12g, Radix Angelicae Dahuricae 6-8g, Rhizoma Atractylodis 6-10g, Radix Puerariae 6-10g, Herba speranskiae tuberculatae 5-7g, Herba Lycopodii 3-5g, Radix Glycyrrhizae 5-7g.
2. Chinese medicine composition as claimed in claim 1, is characterized in that, its crude drug primarily of following weight portion obtains: Cortex Phellodendri 10g, Radix Angelicae Dahuricae 7g, Rhizoma Atractylodis 8g, Radix Puerariae 8g, Herba speranskiae tuberculatae 6g, Herba Lycopodii 4g, Radix Glycyrrhizae 6g.
3. the Chinese medicine composition as described in claim 1 or 2, is characterized in that, described Chinese medicine composition is spray, ointment, lotion, membrane or tincture.
4. the Chinese medicine composition as described in claim 1 or 2, is characterized in that, described Chinese medicine composition is preferably tincture.
5. the Chinese medicine composition as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises following steps: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount water temperature leaching 1h, and decoct 2h, second time adds 6 times amount soak by water 1.5h, filters; When filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.25 ~ 1.30, slowly adds ethanol, make alcohol content reach 75%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, adds appropriate amount of auxiliary materials make clinical acceptable dosage form through normal process steps.
6. the purposes in the phlebitic medicine of Prophylactic chemotherapy prepared by medicine as claimed in claim 1 or 2.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559127A (en) * | 2009-05-25 | 2009-10-21 | 贾荣娟 | Traditional Chinese medicine ointment for treating stage II chemotherapy-induced phlebitis and preparation method |
| CN103251806A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Chinese medicine gel for preventing chemotherapeutic phlebitis and preparation method of Chinese medicine gel |
-
2015
- 2015-06-06 CN CN201510305574.4A patent/CN104873612A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559127A (en) * | 2009-05-25 | 2009-10-21 | 贾荣娟 | Traditional Chinese medicine ointment for treating stage II chemotherapy-induced phlebitis and preparation method |
| CN103251806A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Chinese medicine gel for preventing chemotherapeutic phlebitis and preparation method of Chinese medicine gel |
Non-Patent Citations (1)
| Title |
|---|
| 马会敏等: "金黄膏外敷治疗化疗性静脉炎的护理观察", 《河北中医》 * |
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Application publication date: 20150902 |