CN104873602B - A kind of Chinese medicine for treating the proliferation of mammary gland - Google Patents
A kind of Chinese medicine for treating the proliferation of mammary gland Download PDFInfo
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Abstract
The present invention relates to the Chinese medicines of the treatment proliferation of mammary gland, can effectively solve the problems, such as the medication of the proliferation of mammary gland, and the technical solution solved is made of the material medicine of following parts by weight meter:5 15 parts of 10 30 parts of cottonrose hibiscus leaf, 3 10 parts of honeycomb, 5 20 parts of radix semiaquilegiae, 5 10 parts of armeniaca mume, 5 15 parts of radix bupleuri, 3 10 parts of citron, 15 parts of bitter citrus immature flower, 5 20 parts of blood clam, 5 15 parts of stiff silkworm, 5 20 parts of concha meretricis seu cylinae, 10 30 parts of oyster, 10 40 parts of motherwort, 5 15 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, the present invention has effects that preferably to treat the proliferation of mammary gland, and prescription is simple, it is cheap, using effect is good, is the innovation treated on proliferation of mammary gland drug.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine for treating the proliferation of mammary gland.
Background technology
Cyclomastopathy (hyperplastic disease of breast, HDB) be with mammary gland alveolus, conduit it is upper
Skin tissue cell and connective tissue proliferation are the general name of a kind of disease of basic pathology variation, are a kind of neither tumour is again noninflammatory
Using newborn pain and newborn block for the breast lesion of spy's disease, be the most common breast disease of women.There are about the female of 70%-80% according to investigations
Property has the different degrees of proliferation of mammary gland, is more common in the women of 25-45 Sui.Clinical manifestations are unilateral or bilateral breast occurs
The mass that size, form differ, with local distending pain, string pain or secret anguish, form, size and hardness, by menstrual cycle, feelings
The factors such as thread, fatigue influence.At present there are many kinds of therapies, but effect is undesirable, and Western medicine side effect for oral administration is big merely, treats
Journey is long, expensive;Chinese patent drug effect unobvious for oral administration merely, and high recurrence rate;And operative treatment risk is big, wound is big, disease
People is difficult to receive.Therefore, the problem of improvement treated on the drug of the proliferation of mammary gland is current urgent need to resolve.
The content of the invention
For the above situation, to solve the defect of the prior art, the purpose of the present invention is just to provide a kind of mammary gland for the treatment of and increases
Raw Chinese medicine can effectively solve the problems, such as the medication of the proliferation of mammary gland.
The technical solution that the present invention solves is made of the material medicine of following parts by weight meter:10-30 parts of cottonrose hibiscus leaf,
3-10 parts of honeycomb, 5-20 parts of radix semiaquilegiae, 5-10 parts of armeniaca mume, 5-15 parts of radix bupleuri, 3-10 parts of citron, 1-5 parts of bitter citrus immature flower, corrugation
5-20 parts sub-, 5-15 parts of stiff silkworm, 5-20 parts of concha meretricis seu cylinae, 10-30 parts of oyster, 10-40 parts of motherwort, 5-15 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed 5-
15 parts, above-mentioned raw materials drug being mixed, is added water to submerge, impregnate 2h, intense fire is fried boiling, then is cooked by slow fire 20min, filtering,
The dregs of a decoction add water submergence, and intense fire is fried boiling, then is cooked by slow fire 20min, filtering, merge twice filtrate to get.
The present invention has effects that preferably to treat the proliferation of mammary gland, and prescription is simple, and cheap, using effect is good, is to control
Treat the innovation on proliferation of mammary gland drug.
Specific embodiment
The specific embodiment of the present invention is described in further detail with reference to embodiments.
Embodiment 1
The present invention in the specific implementation, is made of the material medicine of following parts by weight meter:11 parts of cottonrose hibiscus leaf, 9 parts of honeycomb,
6 parts of radix semiaquilegiae, 9 parts of armeniaca mume, 6 parts of radix bupleuri, 9 parts of citron, 2 parts of bitter citrus immature flower, 19 parts of blood clam, 6 parts of stiff silkworm, 19 parts of concha meretricis seu cylinae,
14 parts of 11 parts of oyster, 39 parts of motherwort, 6 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, above-mentioned raw materials drug is mixed, is added water to submerge, and is impregnated
2h, intense fire are fried boiling, then are cooked by slow fire 20min, and filtering, the dregs of a decoction add water submergence, and intense fire is fried boiling, then is cooked by slow fire 20min, mistake
Filter, merge twice filtrate to get.
Embodiment 2
The present invention in the specific implementation, can be made of the material medicine of following parts by weight meter:20 parts of cottonrose hibiscus leaf, honeycomb 6
Part, 12 parts of radix semiaquilegiae, 8 parts of armeniaca mume, 10 parts of radix bupleuri, 7 parts of citron, 3 parts of bitter citrus immature flower, 13 parts of blood clam, 10 parts of stiff silkworm, concha meretricis seu cylinae
10 parts of 12 parts, 20 parts of oyster, 25 parts of motherwort, 10 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, above-mentioned raw materials drug is mixed, adds water logging
Not yet, 2h is impregnated, intense fire is fried boiling, then is cooked by slow fire 20min, and filtering, the dregs of a decoction add water submergence, and intense fire is fried boiling, then is cooked by slow fire
20min, filtering, merge twice filtrate to get.
Embodiment 3
The present invention in the specific implementation, can also be made of the material medicine of following parts by weight meter:29 parts of cottonrose hibiscus leaf, honeycomb
4 parts, 19 parts of radix semiaquilegiae, 6 parts of armeniaca mume, 14 parts of radix bupleuri, 4 parts of citron, 4 parts of bitter citrus immature flower, 6 parts of blood clam, 14 parts of stiff silkworm, sea clam
6 parts of 6 parts of shell, 29 parts of oyster, 11 parts of motherwort, 14 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, above-mentioned raw materials drug is mixed, adds water logging
Not yet, 2h is impregnated, intense fire is fried boiling, then is cooked by slow fire 20min, and filtering, the dregs of a decoction add water submergence, and intense fire is fried boiling, then is cooked by slow fire
20min, filtering, merge twice filtrate to get.
Embodiment 4
The present invention in the specific implementation, can also be made of the material medicine of following parts by weight meter:10-19 parts of cottonrose hibiscus leaf,
3-5 parts of honeycomb, 5-13 parts of radix semiaquilegiae, 5-7 parts of armeniaca mume, 5-9 parts of radix bupleuri, 3-6 parts of citron, 1-2 parts of bitter citrus immature flower, blood clam 5-
5-9 parts of 12 parts, 5-9 parts of stiff silkworm, 5-12 parts of concha meretricis seu cylinae, 10-19 parts of oyster, 10-24 parts of motherwort, 5-9 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, will
Above-mentioned raw materials drug mixes, and adds water to submerge, and impregnates 2h, and intense fire is fried boiling, then is cooked by slow fire 20min, and filtering, the dregs of a decoction add again
Water immersion, intense fire are fried boiling, then are cooked by slow fire 20min, filtering, merge twice filtrate to get.
Embodiment 5
The present invention in the specific implementation, can also be made of the material medicine of following parts by weight meter:21-30 parts of cottonrose hibiscus leaf,
7-10 parts of honeycomb, 14-20 parts of radix semiaquilegiae, 8-10 parts of armeniaca mume, 11-15 parts of radix bupleuri, 7-10 parts of citron, 4-5 parts of bitter citrus immature flower, watt
Stupefied sub- 14-20 parts, 11-15 parts of stiff silkworm, 13-20 parts of concha meretricis seu cylinae, 21-30 parts of oyster, 26-40 parts of motherwort, 11-15 parts of Radix Rhapontici seu Radix Echinopsis and
11-15 parts of tangerine seed, above-mentioned raw materials drug is mixed, is added water to submerge, and impregnates 2h, intense fire is fried boiling, then is cooked by slow fire
20min, filtering, the dregs of a decoction add water submergence, and intense fire is fried boiling, then is cooked by slow fire 20min, filtering, merging twice filtrate to get.
In prescription of the present invention,
Cottonrose hibiscus leaf:It is pungent;It is bitter;It is cool.Major function:Qingfei Liangxue;Removing toxicity for detumescence.Main cough with lung heat;Red eye, swell pain;Ulcer swells
Poison;Malignant sore;Be burdened with She Dan;Impetigo;Pyelonephritis;Scald;Venomous snake bite;Traumatic injury;
Honeycomb:Nature and flavor sweet and neutral.Return stomach.Major function:Wind-dispelling, work(poison, desinsection, analgesic.For dental caries and toothache, sore
Pyogenic infections, acute mastitis, scrofula, skin stubborn dermatitis, the fungal infection of the hand;
Radix semiaquilegiae:Nature and flavor are sweet, bitter, tremble with fear.Return liver, stomach.Major function:It is clearing heat and detoxicating, dispersing swelling and dissipating binds.For carbuncle swells malignant boil
Sore, acute mastitis, scrofula, venomous snake bite;
Armeniaca mume:Nature and flavor:Bitter, micro- sweet and neutral.Major function:Suppressing the hyperactive liver and easing the stomach.For distending pain in the chest and hypochondrium, have a stomachache, indigestion,
Neurasthenia;
Radix bupleuri:It is bitter in taste, it is slightly cold.Return liver, gallbladder channel.Major function:It is soothing the liver in inducing diaphoresis, rising Yang.For cold, fever,
Fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official prolapses, rectal prolapse;
Citron:Nature and flavor are pungent, bitter, sour, temperature.Return liver, spleen, lung channel.Major function:Liver-smoothing, qi-regulating, in wide, resolving sputum.For liver
Stomach Qi is stagnant, distending pain in the chest and hypochondrium, epigastric abdominal fullness, vomits gas, many coughs of phlegm;
Bitter citrus immature flower:Acrid flavour;It is sweet;Slight bitter;It is mild-natured, major function:The wide chest of qi-regulating;Anti-vomiting.Main ruffian in the heart is bored;Gastral cavity abdomen is swollen
Bitterly;Do not feel like eating;Nausea and vomiting;
Blood clam:Nature and flavor are salty, put down.Channel tropism:Return lung, stomach, Liver Channel.Major function:Dissolving phlegm stagnation resolvation, softening and resolving hard mass, relieving haperacidity stop
Bitterly.It accumulates and ties for stupid phlegm, sticky difficulty is coughed up, goiter and tumor, scrofula, abdominal mass lump in the abdomen, pantothenic acid of having a stomachache;
Stiff silkworm:Nature and flavor:It is salty, pungent, it puts down.Return liver, lung, stomach.Major function:Dispelling wind and relieving convulsion, reducing phlegm and resolving masses.It is taken out for infantile convulsion
It jerks, abscess of throat, pruitus, submandibular lymph nodes is scorching, facioplegia;
Concha meretricis seu cylinae:Nature and flavor are salty, put down.Major function:Heat-clearing, Li Shui, resolving sputum, softening hard masses.It controls hot phlegm asthma to cough, oedema, gonorrhoea,
Goitre, knurl, accumulation, blood stasis in the chest pain, bloody flux, hemorrhoid, uterine bleeding, under;
①《This warp》:" main cough with dyspnea, pants, dysphoria, pectoralgia fever and chills."
②《It does not record》:" treat impotence."
③《Haigoushen》:" air supporting of harnessing the river is swollen, lower urine, controls inverse upper gas of coughing, knurl goitre under item."
④《Tang materia medica》:" main 12 water expire shoot, sharp bladder, intestine and small intestine."
⑤《Four tones of standard Chinese pronunciation book on Chinese herbal medicine》:" only quench one's thirst, moisturizing viscera."
⑥《Japan hanako materia medica》:" inverse, impotence of vomitting is controlled, urgency that chest side of body is swollen, pain in the back, five hemorrhoid, married woman's metrorrhagia, vaginal discharge diseases."
⑦《Detailed outline》:" clearing heat and promoting diuresis, resolving sputum drink, disperse accumulation is gathered, and except bloody flux, married woman's blood stasis in the chest, the anti-sweat of typhoid fever is twitched, middle phoenix
Paralysis."
⑧《Modern Practical Chinese medicinal》:" leaching disease is controlled, and has the work(of diuresis."
Oyster:Nature and flavor are salty, are slightly cold.Return liver, courage, kidney channel.Major function:It is transquilization with heavy material, checking exuberance of yang tonifying yin, softening and resolving hard mass.With
In insomnia of palpitating with fear, dizziness and tinnitus, scrofula subcutaneous nodule, abdominal mass lump in the abdomen.Calcined oyster shell restrains astringent method.For spontaneous sweating, band, stomach are collapsed in seminal emission
Pain acid regurgitation;
Motherwort:It is bitter in taste, pungent, it is slightly cold.Return liver, pericardium channel.Major function:Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema.For menstruation
It is uncomfortable, dysmenorrhoea, Amenorrhea, lochiorrhagia, oedema oliguria;Acute nephritis edema.
Radix Rhapontici seu Radix Echinopsis:It is bitter in taste, it trembles with fear.Return stomach.Major function:Clearing heat and detoxicating, disappear carbuncle, and lower breast, relaxing muscles and tendons is promoted blood circulation.It swells for acute mastitis
Bitterly, ulcer carbuncle on the back, scrofula sore, alactation, arthritis with fixed pain caused by dampness contraction.
Tangerine seed:It is bitter in taste, it puts down.Return liver and kidney channel.Major function:Qi-regulating, dissipating bind, analgesic.For herria, testis swells
Bitterly, acute mastitis swells and ache.
Above-mentioned component science, reasonable compatibility, mutually support, effective for treat the proliferation of mammary gland, good effect, drug safety,
It has no toxic side effect, curative effect is stablized, and securely and reliably, and has obtained fully proving through experiment, related experimental data is as follows:
1 clinical data
1.1 general information
102 patients are randomly divided into treatment group and control group.Treatment group 52, age 20-51 Sui, average age 46.3
Year;The course of disease -10 years 6 months, it is 4.9 years average;Unilateral breast is fallen ill 19, and bilateral breast is fallen ill 33;Newborn pain degree:Slight 13
Example, moderate 30, severe 9.
Control group 50, age 19-48 Sui, average age 44.7 years old;The course of disease -11 years 6 months, it is 4.5 years average;Unilateral breast
Room is fallen ill 17, and bilateral breast is fallen ill 33;Newborn pain degree:Slight 10, moderate 30, severe 10.Two groups in age disease
Journey, is distributed in the state of an illness close, is statistically analyzed no significant difference (P>0.05), it is comparable.
1.2 diagnostic criteria are with reference to State Administration of Traditional Chinese Medicine's issue in 1994《Chinese medical disease Standardization of diagnosis and curative effect》Intend
It is fixed.(1) periodical swollen breasts, mostly occur or aggravate in premenstrua.(2) one side or bilateral breast occur differing in size, item
Strand or diffusivity piece are block, and matter is tough, and border owes clear, have the tubercle of tenderness, with surrounding tissue without adhesion.(3) local skin
Without redness, axillary lymph knot is without enlargement.(4) scanning of mammary gland infrared link, molybdenum target photo, color Doppler ultrasound examination or pin are inhaled
Cytoscopy is diagnosed as cyclomastopathy.
1.3 exclusion criterias (1) exclude other mammary gland diseases such as breast cancer, fibroadenoma of breast.(2) exclude to merge painstaking effort
Serious conditions and the mental patients such as pipe, liver kidney and hemopoietic system.(3) gestation, women breast-feeding their children.(4) not by predetermined treatment, nothing
Method judges curative effect, or the not congruent judgement person that affects the treatment of data.
Therapeutic scheme
Chinese medicine of the present invention is taken by 2.1 treatment groups, once in the morning and once at night, warmly takes, and each 200-300ml, menstrual period withdraw, 3
The moon is 1 course for the treatment of.
2.2 control groups take orally rupixiao tablets, rupixiao pian (the good nurse's board in Liaoning), and every 0.32g, 6 tablets once, and 3 times a day, March is
1 course for the treatment of.During two groups of treatments, without the other medicines related with treating this disease, count and treat after 3 menstrual cycles of continuous use
Effect.
Curative effect determinate standard
3.1 observation items observe two groups of pretherapy and post-treatment clinical symptoms, sign variation, infrared ray breast scanning, mammary gland molybdenum
Target photo, color Doppler ultrasound examination, a situation arises for blood, routine urinalysis, Liver and kidney function inspection and adverse reaction.
The effect of 3.2 criterions of therapeutical effect are formulated with reference to Society of Surgery of All-China Association of Traditional Chinese Medicine mastosis special topic group standard
[Wang Gentai, Yang Limin, Zhu Feng, etc..The Chinese combination of Chinese tradiational and Western medicine magazine of newborn recovery treating hyperplasia of mammary glands 100 [J],
1998, 18 (7):441] draft.
It cures:Lump in breast and breast pain disappear, and do not recur within 3 months after drug withdrawal;
It is effective;Lump in breast reduces more than 1/2, and breast pain disappears;
Effectively:Lump in breast maximum gauge is reduced less than 1/2, and breast pain mitigates;
It is invalid:Lump in breast does not reduce, and increases instead, is hardened, or simple breast pain is alleviated.
Statistical procedures
By above-mentioned therapeutic scheme, Chinese medicine that the oral present invention provides, continuous use counts curative effect after 3 menstrual cycles, right
Patient 52 of the clinical definite with the proliferation of mammary gland is treated, 20 people of clinical cure, effective 19 people, effective 11 people, and invalid 2
People, total effective rate 96.15%, control group 50,9 people of clinical cure, effective 13 people, effective 18 people, invalid 10 people, total effective rate
80%, compared with the control group, * P < 0.05, * * P < 0.01, difference is statistically significant, shows the invention Chinese medicine for treatment group
Proliferation of mammary gland significant effect is treated, has reached clinical treatment purpose, and treatment group is over the course for the treatment of, no obvious toxicity
Occur, pretherapy and post-treatment blood, routine urinalysis, Liver and kidney function are relatively showed no anomalous variation.
1 two groups of proliferation of mammary gland patient treatment results of table compare [n (%)]
Compared with the control group, * P < 0.05, * * P < 0.01
5 conclusions
The present invention has effects that preferably to treat the proliferation of mammary gland, and prescription is simple, and cheap, using effect is good, is to control
The innovation on proliferation of mammary gland drug is treated, there is good economic and social benefit.
Claims (6)
1. a kind of Chinese medicine for treating the proliferation of mammary gland, which is characterized in that be made of the material medicine of following parts by weight meter:Cottonrose hibiscus leaf
10-30 parts, 3-10 parts of honeycomb, 5-20 parts of radix semiaquilegiae, 5-10 parts of armeniaca mume, 5-15 parts of radix bupleuri, 3-10 parts of citron, bitter citrus immature flower 1-5
Part, 5-20 parts of blood clam, 5-15 parts of stiff silkworm, 5-20 parts of concha meretricis seu cylinae, 10-30 parts of oyster, 10-40 parts of motherwort, 5-15 parts of Radix Rhapontici seu Radix Echinopsis
With 5-15 parts of tangerine seed, above-mentioned raw materials drug is mixed, is added water to submerge, impregnate 2h, intense fire is fried boiling, then is cooked by slow fire
20min, filtering, the dregs of a decoction add water submergence, and intense fire is fried boiling, then is cooked by slow fire 20min, filtering, merging twice filtrate to get.
2. the Chinese medicine of the treatment proliferation of mammary gland according to claim 1, which is characterized in that 11 parts of cottonrose hibiscus leaf, honeycomb 9 part, day
It is 6 parts of certain herbaceous plants with big flowers, 9 parts of armeniaca mume, 6 parts of radix bupleuri, 9 parts of citron, 2 parts of bitter citrus immature flower, 19 parts of blood clam, 6 parts of stiff silkworm, 19 parts of concha meretricis seu cylinae, male
14 parts of 11 parts of oyster, 39 parts of motherwort, 6 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, above-mentioned raw materials drug is mixed, is added water to submerge, and impregnates 2h,
Intense fire is fried boiling, then is cooked by slow fire 20min, and filtering, the dregs of a decoction add water submergence, and intense fire is fried boiling, then is cooked by slow fire 20min, filters, and closes
And twice filtrate to get.
3. the Chinese medicine of the treatment proliferation of mammary gland according to claim 1, which is characterized in that by the raw material of following parts by weight meter
Drug is made:20 parts of cottonrose hibiscus leaf, 6 parts of honeycomb, 12 parts of radix semiaquilegiae, 8 parts of armeniaca mume, 10 parts of radix bupleuri, 7 parts of citron, 3 parts of bitter citrus immature flower,
10 parts of 13 parts of blood clam, 10 parts of stiff silkworm, 12 parts of concha meretricis seu cylinae, 20 parts of oyster, 25 parts of motherwort, 10 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, will be above-mentioned
Material medicine mixes, and adds water to submerge, and impregnates 2h, and intense fire is fried boiling, then is cooked by slow fire 20min, and filtering, the dregs of a decoction add water leaching
Not yet, intense fire is fried boiling, then is cooked by slow fire 20min, filtering, merge twice filtrate to get.
4. the Chinese medicine of the treatment proliferation of mammary gland according to claim 1, which is characterized in that by the raw material of following parts by weight meter
Drug is made:29 parts of cottonrose hibiscus leaf, 4 parts of honeycomb, 19 parts of radix semiaquilegiae, 6 parts of armeniaca mume, 14 parts of radix bupleuri, 4 parts of citron, 4 parts of bitter citrus immature flower,
6 parts of 6 parts of blood clam, 14 parts of stiff silkworm, 6 parts of concha meretricis seu cylinae, 29 parts of oyster, 11 parts of motherwort, 14 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, by above-mentioned raw materials
Drug mixes, and adds water to submerge, and impregnates 2h, and intense fire is fried boiling, then is cooked by slow fire 20min, and filtering, the dregs of a decoction add water submergence,
Intense fire is fried boiling, then is cooked by slow fire 20min, filtering, merge twice filtrate to get.
5. the Chinese medicine of the treatment proliferation of mammary gland according to claim 1, which is characterized in that by the raw material of following parts by weight meter
Drug is made:10-19 parts of cottonrose hibiscus leaf, 3-5 parts of honeycomb, 5-13 parts of radix semiaquilegiae, 5-7 parts of armeniaca mume, 5-9 parts of radix bupleuri, citron 3-6
Part, 1-2 parts of bitter citrus immature flower, 5-12 parts of blood clam, 5-9 parts of stiff silkworm, 5-12 parts of concha meretricis seu cylinae, 10-19 parts of oyster, 10-24 parts of motherwort,
5-9 parts of 5-9 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, above-mentioned raw materials drug is mixed, is added water to submerge, and impregnates 2h, intense fire is fried boiling, then slow boiling
20min, filtering are decocted, the dregs of a decoction add water submergence, and intense fire is fried boiling, then is cooked by slow fire 20min, and filtering merges filtrate twice, i.e.,
.
6. the Chinese medicine of the treatment proliferation of mammary gland according to claim 1, which is characterized in that by the raw material of following parts by weight meter
Drug is made:21-30 parts of cottonrose hibiscus leaf, 7-10 parts of honeycomb, 14-20 parts of radix semiaquilegiae, 8-10 parts of armeniaca mume, 11-15 parts of radix bupleuri, perfume
7-10 parts of rafter, 4-5 parts of bitter citrus immature flower, 14-20 parts of blood clam, 11-15 parts of stiff silkworm, 13-20 parts of concha meretricis seu cylinae, 21-30 parts of oyster, benefit are female
11-15 parts of 26-40 parts careless, 11-15 parts of Radix Rhapontici seu Radix Echinopsis and tangerine seed, above-mentioned raw materials drug is mixed, is added water to submerge, and impregnates 2h,
Intense fire is fried boiling, then is cooked by slow fire 20min, and filtering, the dregs of a decoction add water submergence, and intense fire is fried boiling, then is cooked by slow fire 20min, filters, and closes
And twice filtrate to get.
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Granted publication date: 20180529 Termination date: 20190528 |