CN104872332A - Preparation method of alcohol-effect-dispelling and liver-protection health tea - Google Patents
Preparation method of alcohol-effect-dispelling and liver-protection health tea Download PDFInfo
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- CN104872332A CN104872332A CN201510257161.3A CN201510257161A CN104872332A CN 104872332 A CN104872332 A CN 104872332A CN 201510257161 A CN201510257161 A CN 201510257161A CN 104872332 A CN104872332 A CN 104872332A
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Abstract
The invention discloses a preparation method of alcohol-effect-dispelling and liver-protection health tea. The preparation method comprises the following steps: smashing white pueraria flowers, inula flowers, honeysuckle flowers, shrub althea flowers, angelica sinensis, flos farfarae flowers, areca catechu peel and radix aucklandiae into crude powder, impregnating with an ethanol water solution for percolation, collecting percolating liquid, recycling ethanol to obtain a concentrated solution, extracting with ethyl acetate, performing pressure reduction recovery to extract liquid to obtain an extracting solution I; then uniformly mixing rehmannia glutinosa, white paeony root, sanguisorba officinalis, rhizoma coptidis, querus mongolica fisch branch, radix puerariae, liquorice, schisandra chinensis and ligusticum wallichii, extracting by adopting a supercritical carbon dioxide fluid extraction method, and separating to obtain an extracting solution II; and mixing the extracting solution I and the extracting solution II to obtain a mixed solution, performing ultrafiltration concentration on the mixed solution to obtain filtrate, spraying the filtrate on brick tea, drying, and frying to obtain finished products. The alcohol-effect-dispelling and liver-protection health tea has the good anti-oxidative damage function and has the efficacies on dispelling the alcohol effect and protecting liver.
Description
Technical field
The invention belongs to health product technology field, be specifically related to a kind of preparation method of Dealcoholic liver-protecting tea.
Background technology
Edible wine is a kind of health drink, can stimulate circulation, stimulate the circulation of the blood and cause the muscles and joints to relax, wines used as antirheumatic.Responsible drinking is good for health, but excessive, can be harmful to health: first, and the direct impariment of the liver of excessive consumption of alcohol, easily causes alcoholic liver, hepatitis and cirrhosis, and after hepatic disease, eyesight and immunity degradation, easily infect other diseases; Secondly, excessive consumption of alcohol also can injure heart, spleen, pancreas and kidney, easily causes hypertension, cardiovascular disease etc., endangers very large.Therefore, people seek the method that can relieve the effect of alcohol fast always.The Main Ingredients and Appearance of wine is ethanol, possesses alcohol dehydrogenase in human body, makes ethanol decomposition become acetaldehyde, and acetaldehyde becomes acetic acid through the decomposition of acetaldehyde dehydrogenase again, and acetic acid does not injure human body, can resolve into carbon dioxide and water, ethanol and acetaldehyde large to harm.Some people is not good at drinking, and namely lacks acetaldehyde dehydrogenase, and acetaldehyde stays in the body, and people is felt sick and goes into a coma.It is found that a lot of natural good medicine that relieves the effect of alcohol since ancient times: FI puerariae energy acceleration of alcohol is oxidized, the absorption of alleviation of alcohol, and hindered alcohol enters blood circulation; Glossy ganoderma can help human body fast decoupled to go out alcohol dehydrogenase and acetaldehyde dehydrogenase, can alcohol in fast decoupled human body, and glossy ganoderma has protective effect to liver; Galangal have warm stomach fall apart cold, help digestion and to sober up, control the effect of stomach crymodynia; Dandelion energy removing toxicity for detumescence, especially kind removing heat from the liver; Olive be sober up, clearing away the stomach-heat and orectic good medicine, can effectively improve anorexia after drinking; Fruit also contributes to relieving the effect of alcohol, and the organic acid in fruit and ethanol interact, and forms Ester, thus reaches object of relieving the effect of alcohol.
Now, along with the continuous reinforcement of health of people consciousness, after tea beverage market expands rapidly, to add the new highlight that tradition Herb Tea that is edible or medicine food dual purpose plant has become drinking markets.In recent years, fatty liver, alcoholic liver etc. have become one of principal disease of society threat human health.How by scientific compatibility, modulate a there is relieving alcoholism and protecting liver effect, taste flavor health protection tea that is comfortable, that be applicable to drinking for a long time will have good market prospects.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and the preparation method providing a kind of relieving alcoholism and protecting liver health protection tea, this health protection tea has the effect of good anti-oxidative damage, can play effect of relieving alcoholism and protecting liver.
A preparation method for relieving alcoholism and protecting liver health protection tea, comprises the following steps:
Step 1, with parts by weight, get white FI puerariae 2 ~ 6 parts, Inula britannica chinensis 1 ~ 7 part, honeysuckle 3 ~ 8 parts, shrub althea flower 2 ~ 7 parts, Radix Angelicae Sinensis 1 ~ 6 part, tussilago 3 ~ 5 parts, abdomen skin 2 ~ 8 parts, the banksia rose 1 ~ 9 part, be ground into meal, carry out diacolation with after ethanol water dipping, diacolation speed is 3 ~ 5mL/min, collect percolate, reclaim ethanol and obtain concentrate, then be extracted with ethyl acetate, gained extract recovered under reduced pressure, obtains extract I;
Step 2, with parts by weight, get 3 ~ 7 parts, cultivated land, the root of herbaceous peony 2 ~ 6 parts, garden burnet 1 ~ 5 part, the coptis 3 ~ 8 parts, 4 ~ 7 parts, toothed oak branch, the root of kudzu vine 2 ~ 8 parts, 1 ~ 9 part, Radix Glycyrrhizae, 3 ~ 6 parts, the fruit of Chinese magnoliavine and Ligusticum wallichii 2 ~ 8 parts, mix, first extracted by supercritical carbon dioxide extraction method, be separated, obtain extract II;
Step 3, mixes step 1 gained extract I and step 2 gained extract II, and mixed liquor is after ultrafiltration concentration, and be injected on Fu tea, post-drying, frying, to obtain final product.
As the further improvement of foregoing invention, in step 1, meal particle diameter is 40 ~ 60 orders.
As the further improvement of foregoing invention, in step 1, ethanol water concentration is 80 ~ 95v/v%.
As the further improvement of foregoing invention, in step 2, extracting pressure is 12MPa, and extraction temperature is 42 DEG C, and extraction time is 2.5h.
As the further improvement of foregoing invention, in step 2, separating pressure is 6MPa, and separation temperature is 40 DEG C.
As the further improvement of foregoing invention, the milipore filter molecular cut off that in step 3, ultrafiltration concentration is used is 200kDa.
Relieving alcoholism and protecting liver health protection tea of the present invention has the effect of good anti-oxidative damage, can play effect of relieving alcoholism and protecting liver.
Detailed description of the invention
Embodiment 1
A preparation method for relieving alcoholism and protecting liver health protection tea, comprises the following steps:
Step 1, with parts by weight, get white FI puerariae 2 parts, Inula britannica chinensis 1 part, honeysuckle 3 parts, shrub althea flower 2 parts, Radix Angelicae Sinensis 1 part, tussilago 3 parts, abdomen skin 2 parts, the banksia rose 1 part, be ground into meal, meal particle diameter is 40 orders, carry out diacolation with after 80v/v% ethanol water dipping, diacolation speed is 3mL/min, collects percolate, reclaim ethanol and obtain concentrate, be extracted with ethyl acetate, gained extract recovered under reduced pressure, obtains extract I again;
Step 2, with parts by weight, get 3 parts, cultivated land, the root of herbaceous peony 2 parts, garden burnet 1 part, the coptis 3 parts, 4 parts, toothed oak branch, the root of kudzu vine 2 parts, 1 part, Radix Glycyrrhizae, 3 parts, the fruit of Chinese magnoliavine and Ligusticum wallichii 2 parts, mix, first extracted by supercritical carbon dioxide extraction method, extracting pressure is 12MPa, and extraction temperature is 42 DEG C, and extraction time is 2.5h, be separated again, separating pressure is 6MPa, and separation temperature is 40 DEG C, obtains extract II;
Step 3, mixes step 1 gained extract I and step 2 gained extract II, and mixed liquor is after the milipore filter that molecular cut off is 200kDa concentrates, and be injected on Fu tea, post-drying, frying, to obtain final product.
Embodiment 2
A preparation method for relieving alcoholism and protecting liver health protection tea, comprises the following steps:
Step 1, with parts by weight, get white FI puerariae 3 parts, Inula britannica chinensis 5 parts, honeysuckle 7 parts, shrub althea flower 3 parts, Radix Angelicae Sinensis 5 parts, tussilago 4 parts, abdomen skin 7 parts, the banksia rose 6 parts, be ground into meal, meal particle diameter is 50 orders, carry out diacolation with after 85v/v% ethanol water dipping, diacolation speed is 4mL/min, collects percolate, reclaim ethanol and obtain concentrate, be extracted with ethyl acetate, gained extract recovered under reduced pressure, obtains extract I again;
Step 2, with parts by weight, get 4 parts, cultivated land, the root of herbaceous peony 5 parts, garden burnet 2 parts, the coptis 6 parts, 5 parts, toothed oak branch, the root of kudzu vine 5 parts, 8 parts, Radix Glycyrrhizae, 4 parts, the fruit of Chinese magnoliavine and Ligusticum wallichii 6 parts, mix, first extracted by supercritical carbon dioxide extraction method, extracting pressure is 12MPa, and extraction temperature is 42 DEG C, and extraction time is 2.5h, be separated again, separating pressure is 6MPa, and separation temperature is 40 DEG C, obtains extract II;
Step 3, mixes step 1 gained extract I and step 2 gained extract II, and mixed liquor is after the milipore filter that molecular cut off is 200kDa concentrates, and be injected on Fu tea, post-drying, frying, to obtain final product.
Embodiment 3
A preparation method for relieving alcoholism and protecting liver health protection tea, comprises the following steps:
Step 1, with parts by weight, get white FI puerariae 6 parts, Inula britannica chinensis 7 parts, honeysuckle 8 parts, shrub althea flower 7 parts, Radix Angelicae Sinensis 6 parts, tussilago 5 parts, abdomen skin 8 parts, the banksia rose 9 parts, be ground into meal, meal particle diameter is 60 orders, carry out diacolation with after 90v/v% ethanol water dipping, diacolation speed is 5mL/min, collects percolate, reclaim ethanol and obtain concentrate, be extracted with ethyl acetate, gained extract recovered under reduced pressure, obtains extract I again;
Step 2, with parts by weight, get 7 parts, cultivated land, the root of herbaceous peony 6 parts, garden burnet 5 parts, the coptis 8 parts, 7 parts, toothed oak branch, the root of kudzu vine 8 parts, 9 parts, Radix Glycyrrhizae, 6 parts, the fruit of Chinese magnoliavine and Ligusticum wallichii 8 parts, mix, first extracted by supercritical carbon dioxide extraction method, extracting pressure is 12MPa, and extraction temperature is 42 DEG C, and extraction time is 2.5h, be separated again, separating pressure is 6MPa, and separation temperature is 40 DEG C, obtains extract II;
Step 3, mixes step 1 gained extract I and step 2 gained extract II, and mixed liquor is after the milipore filter that molecular cut off is 200kDa concentrates, and be injected on Fu tea, post-drying, frying, to obtain final product.
Reparation Liver damaged animal is tested
Male mice SPF level, in three week age, 30-35g, after adapting to feed 3d, is divided into Normal group, model group, test group and MPG positive controls at random.Each group of every day feeds basal feed, test group and MPG group give embodiment 2 products obtained therefrom and the MPG of corresponding dosage respectively, model control group, test group and MPG positive controls gavage is given respectively with ethanol 3g/kg (0.01mL/g) after 6h, Normal group gives equal-volume distilled water, after continuous 25 days, fasting 2h after last administration, broken end gets blood system from determination of serum glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST), triglyceride (TG).Get appropriate hepatic tissue and make 10% homogenate, measure the content of MDA (MDA), total sulfydryl; Get liver maximum blade frozen section, HE dyes, and observes lipopexia situation.
Result shows:
1) test group obviously can reduce the liver system number of mouse, shows that it can reduce accumulation of lipid to a certain extent, plays liver-protective effect;
2) test group obviously can reduce the level of ALT, AST, TG of mice serum, and wherein the content of AST and TG of high dose group reaches extremely significant level, and the content of the AST of low dose group reaches the level of signifiance;
3) drink the raising that product of the present invention can stimulate GSHpx enzymatic activity in Mice Body, by the assay to the total sulfydryl of polyphenoils, the present invention can improve the content of total sulfydryl in Mice Body significantly;
4) the present invention can alleviate the hepatocellular injury that liver histopathology changes and reparation alcoholic liver causes that alcohol causes, and after drinking, fatization sex change easily appears in mouse liver, and liver is loose, and color and luster shoals, and has greasy feeling; Drink the mouse after this formula Herb Tea product, liver is ruddy, normal in size.By cutting into slices to liver organization and HE dyeing, show, after drinking Herb Tea, compared with model group, the circular cavity of liver cell obviously reduces, and sinus hepaticus cell size, shape are close to normal.
Claims (6)
1. a preparation method for relieving alcoholism and protecting liver health protection tea, is characterized in that: comprise the following steps:
Step 1, with parts by weight, get white FI puerariae 2 ~ 6 parts, Inula britannica chinensis 1 ~ 7 part, honeysuckle 3 ~ 8 parts, shrub althea flower 2 ~ 7 parts, Radix Angelicae Sinensis 1 ~ 6 part, tussilago 3 ~ 5 parts, abdomen skin 2 ~ 8 parts, the banksia rose 1 ~ 9 part, be ground into meal, carry out diacolation with after ethanol water dipping, diacolation speed is 3 ~ 5mL/min, collect percolate, reclaim ethanol and obtain concentrate, then be extracted with ethyl acetate, gained extract recovered under reduced pressure, obtains extract I;
Step 2, with parts by weight, get 3 ~ 7 parts, cultivated land, the root of herbaceous peony 2 ~ 6 parts, garden burnet 1 ~ 5 part, the coptis 3 ~ 8 parts, 4 ~ 7 parts, toothed oak branch, the root of kudzu vine 2 ~ 8 parts, 1 ~ 9 part, Radix Glycyrrhizae, 3 ~ 6 parts, the fruit of Chinese magnoliavine and Ligusticum wallichii 2 ~ 8 parts, mix, first extracted by supercritical carbon dioxide extraction method, be separated again, obtain extract II;
Step 3, mixes step 1 gained extract I and step 2 gained extract II, and mixed liquor is after ultrafiltration concentration, and be injected on Fu tea, post-drying, frying, to obtain final product.
2. the preparation method of relieving alcoholism and protecting liver health protection tea according to claim 1, is characterized in that: in step 1, meal particle diameter is 40 ~ 60 orders.
3. the preparation method of relieving alcoholism and protecting liver health protection tea according to claim 1, is characterized in that: in step 1, ethanol water concentration is 80 ~ 95v/v%.
4. the preparation method of relieving alcoholism and protecting liver health protection tea according to claim 1, is characterized in that: in step 2, extracting pressure is 12MPa, and extraction temperature is 42 DEG C, and extraction time is 2.5h.
5. the preparation method of relieving alcoholism and protecting liver health protection tea according to claim 1, is characterized in that: in step 2, separating pressure is 6MPa, and separation temperature is 40 DEG C.
6. the preparation method of relieving alcoholism and protecting liver health protection tea according to claim 1, is characterized in that: the milipore filter molecular cut off that in step 3, ultrafiltration concentration is used is 200kDa.
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| CN103875848A (en) * | 2014-02-26 | 2014-06-25 | 湖南农业大学 | Herbal Fu tea capable of alleviating hangover and protecting liver |
| CN104274705A (en) * | 2014-09-23 | 2015-01-14 | 苏州市天灵中药饮片有限公司 | Sobering and liver protecting chewable tablet and preparation method thereof |
| CN104288652A (en) * | 2014-10-15 | 2015-01-21 | 圣原健康产业有限公司 | Traditional Chinese medicine composition with hangover-alleviating health care effect and preparation method and application of traditional Chinese medicine composition |
| CN104383315A (en) * | 2014-10-28 | 2015-03-04 | 湖南中医药大学 | Chinese herbal medicinal composition for protecting liver and sobering and drink containing Chinese herbal medicinal composition |
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2015
- 2015-05-20 CN CN201510257161.3A patent/CN104872332A/en active Pending
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| CN1330944A (en) * | 2000-06-27 | 2002-01-16 | 韩子逸 | Tea for giving up smoking |
| CN1579486A (en) * | 2004-03-30 | 2005-02-16 | 张继凤 | Sobering tea and its preparation method |
| CN103875848A (en) * | 2014-02-26 | 2014-06-25 | 湖南农业大学 | Herbal Fu tea capable of alleviating hangover and protecting liver |
| CN104274705A (en) * | 2014-09-23 | 2015-01-14 | 苏州市天灵中药饮片有限公司 | Sobering and liver protecting chewable tablet and preparation method thereof |
| CN104288652A (en) * | 2014-10-15 | 2015-01-21 | 圣原健康产业有限公司 | Traditional Chinese medicine composition with hangover-alleviating health care effect and preparation method and application of traditional Chinese medicine composition |
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Application publication date: 20150902 |
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