CN104861066B - 治疗癌症和纤维化疾病的化合物组合物和方法 - Google Patents
治疗癌症和纤维化疾病的化合物组合物和方法 Download PDFInfo
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| US9572832B2 (en) * | 2013-08-29 | 2017-02-21 | Holy Stone Healthcare Co., Ltd. | Compound of glycosaminoglycan and its fabrication method as well as application |
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| US20170266166A1 (en) * | 2014-05-17 | 2017-09-21 | University Of Rochester | Compositions and Methods to Inhibit Estrogen Receptor Beta for the Treatment of Renal Cell Carcinoma |
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| CN118994394A (zh) | 2017-06-12 | 2024-11-22 | 蓝鳍生物医药公司 | 抗-il1rap抗体和抗体药物缀合物 |
| JP7232453B2 (ja) * | 2017-09-15 | 2023-03-03 | 学校法人杏林学園 | 糖尿病網膜症、白内障及び／又は腎症モデル実験動物 |
| JP7674354B2 (ja) * | 2019-12-05 | 2025-05-09 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 肝線維症および線維症に関連する他の疾患に対するエキソソームベースの療法 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| WO2023275112A1 (en) | 2021-06-29 | 2023-01-05 | Rigshospitalet | Antibody-drug conjugates comprising humanized antibodies targeting urokinase type plasminogen activator receptor associated protein (uparap) |
| CN120456932A (zh) | 2022-12-28 | 2025-08-08 | 艾德森多有限公司 | 包含依喜替康衍生物的靶向uPARAP的抗体偶联药物 |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| WO2025126157A1 (en) | 2023-12-15 | 2025-06-19 | Advesya | Anti-il-1rap binding domains and antibody-drug conjugates thereof |
| EP4578463A1 (en) * | 2023-12-29 | 2025-07-02 | Oncomatryx Biopharma, S.L. | Endo-180 targeted antibody-drug conjugates |
| WO2025141153A1 (en) * | 2023-12-29 | 2025-07-03 | Oncomatryx Biopharma, S.L. | Endo180 targeted antibody-drug conjugates |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004100759A2 (en) * | 2003-05-19 | 2004-11-25 | Quark Biotech, Inc. | Endo 180 receptor for diagnosis and treatment |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL81370A (en) * | 1986-02-07 | 1991-06-30 | Genetic Systems Corp | Pharmaceutical and diagnostic compositions comprising a plurality of human monoclonal antibodies for the treatment of bacterial diseases,methods for the preparation of the compositions and antibodies and kits containing said compositions |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6153737A (en) | 1990-01-11 | 2000-11-28 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
| US6235886B1 (en) | 1993-09-03 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Methods of synthesis and use |
| US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
| US5773268A (en) * | 1994-11-09 | 1998-06-30 | Cedars-Sinai Medical Center | Chromosome 21 gene marker, compositions and methods using same |
| US6117977A (en) | 1996-04-24 | 2000-09-12 | Genentech, Inc. | Type C lectins |
| ZA973051B (en) | 1996-04-24 | 1998-10-12 | Genentech Inc | Type c lectins |
| US20050042647A1 (en) | 1996-06-06 | 2005-02-24 | Baker Brenda F. | Phosphorous-linked oligomeric compounds and their use in gene modulation |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| US6251666B1 (en) | 1997-03-31 | 2001-06-26 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid catalysts comprising L-nucleotide analogs |
| US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
| US6077508A (en) | 1998-03-23 | 2000-06-20 | American Diagnostica Inc. | Urokinase plasminogen activator receptor as a target for diagnosis of metastases |
| CA2383592A1 (en) | 1999-03-31 | 2000-10-05 | Curagen Corporation | 2384891 acids including open reading frames encoding polypeptides; orfx |
| DE50015293D1 (de) | 1999-04-13 | 2008-09-11 | Wilex Ag | Diagnostischer und therapeutischer Einsatz von Antikörpern gegen den Urokinase-Rezeptor |
| US7829064B2 (en) * | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
| WO2001029058A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
| KR100909681B1 (ko) | 2000-12-01 | 2009-07-29 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자 |
| US7544374B2 (en) | 2001-08-14 | 2009-06-09 | Tel Aviv University Future Technology Development L.P. | Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy |
| US20040248835A1 (en) | 2001-10-26 | 2004-12-09 | Anja Krebs | Use of a double-stranded ribonucleic acid for treating an infection with a positivestrand rna-virus |
| DE10230997A1 (de) | 2001-10-26 | 2003-07-17 | Ribopharma Ag | Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels |
| US7795422B2 (en) | 2002-02-20 | 2010-09-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
| US7452987B2 (en) | 2002-08-05 | 2008-11-18 | Silence Therapeutics Aktiengesellschaft (Ag) | Interfering RNA molecules |
| US8729036B2 (en) | 2002-08-07 | 2014-05-20 | University Of Massachusetts | Compositions for RNA interference and methods of use thereof |
| EP2213738B1 (en) | 2002-11-14 | 2012-10-10 | Dharmacon, Inc. | siRNA molecules targeting Bcl-2 |
| US7842800B2 (en) | 2004-04-02 | 2010-11-30 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory bacterial and bacterial associated oligonucleotides and uses thereof |
| US8808664B2 (en) | 2004-07-13 | 2014-08-19 | Ramot At Tel-Aviv University Ltd. | Lipidated glycoprotein particles and methods of use |
| EP1789447B1 (en) | 2004-08-16 | 2012-04-25 | Immune Disease Institute, Inc. | Method of delivering rna interference and uses thereof |
| WO2006050246A2 (en) | 2004-11-02 | 2006-05-11 | Tel-Aviv University Future Technology Development L.P. | Formulations of water insoluble or poorly water soluble drugs in lipidated glycosaminoglycan particles, their manufacturing and their use for diagnostics and therapy |
| WO2008020435A2 (en) | 2006-08-15 | 2008-02-21 | Quark Pharmaceuticals, Inc | Compositions and methods for treatment of mood disorders |
| JP2010507387A (ja) | 2006-10-25 | 2010-03-11 | クアーク・ファーマスーティカルス、インコーポレイテッド | 新規のｓｉＲＮＡおよびその使用方法 |
| US20100292301A1 (en) | 2007-02-28 | 2010-11-18 | Elena Feinstein | Novel sirna structures |
| WO2008109105A2 (en) * | 2007-03-06 | 2008-09-12 | Flagship Ventures | Methods and compositions for improved therapeutic effects with sirna |
| US8614309B2 (en) | 2007-10-03 | 2013-12-24 | Quark Pharmaceuticals, Inc. | Double-stranded RNA directed to CASP2 and methods of use thereof |
| US8632803B2 (en) * | 2008-02-27 | 2014-01-21 | Ramot At Tel-Aviv University Ltd. | System for delivery of protein in insoluble fibrillar or aggregate form |
| JP5830460B2 (ja) | 2009-03-23 | 2015-12-09 | クォーク ファーマシューティカルズ インコーポレーティッドＱｕａｒｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 癌および線維性疾患を治療する化合物、組成物、および方法 |
| EP2504435B1 (en) | 2009-11-26 | 2019-11-13 | Quark Pharmaceuticals, Inc. | Sirna compounds comprising terminal substitutions |
-
2010
- 2010-03-23 JP JP2012502150A patent/JP5830460B2/ja not_active Expired - Fee Related
- 2010-03-23 CN CN201510009172.XA patent/CN104861066B/zh not_active Expired - Fee Related
- 2010-03-23 US US13/255,214 patent/US8444983B2/en active Active
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- 2010-03-23 EP EP10722812.4A patent/EP2411413B1/en not_active Not-in-force
- 2010-03-23 SG SG2011065935A patent/SG174367A1/en unknown
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- 2015-07-09 US US14/795,429 patent/US9993567B2/en active Active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004100759A2 (en) * | 2003-05-19 | 2004-11-25 | Quark Biotech, Inc. | Endo 180 receptor for diagnosis and treatment |
Non-Patent Citations (2)
| Title |
|---|
| Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer;Jay Sulek;《Journal of histochemistry & cytochemistry》;20071231;第55卷(第4期);第347-353页 * |
| p180,a novel recycling transmembrane glycoprotein with restricted cell type expression;Clare M. Isacke;《Molecular and cellular》;19900630;第10卷(第6期);第2606-2618页 * |
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| US20150359905A1 (en) | 2015-12-17 |
| IL215061A0 (en) | 2011-11-30 |
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| US8444983B2 (en) | 2013-05-21 |
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| US20140072552A1 (en) | 2014-03-13 |
| CA2753388C (en) | 2016-11-29 |
| EP2411413A1 (en) | 2012-02-01 |
| JP5830460B2 (ja) | 2015-12-09 |
| CA2753388A1 (en) | 2010-09-30 |
| CN104861066A (zh) | 2015-08-26 |
| JP2016034945A (ja) | 2016-03-17 |
| US9993567B2 (en) | 2018-06-12 |
| WO2010111198A1 (en) | 2010-09-30 |
| JP2012521217A (ja) | 2012-09-13 |
| CN102378766A (zh) | 2012-03-14 |
| IL235026A (en) | 2016-10-31 |
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