CN104857147A - 一种润肠通便丸 - Google Patents
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Abstract
本发明涉及一种润肠通便丸，其成分由熟大黄40g、火麻仁40g、肉苁蓉48g、郁李仁40g、厚朴24g、枳实48g、当归48g、熟地40g、牛膝40g、地榆40g、白芍40g、川芎40g组成。该润肠通便丸润攻结合，且润大于攻，使下不伤正，诸药合用，共奏润肠通便，化痔散结之功。标本兼治，对症治疗性强，制作简单，可一次性大批量生产，成药制剂携带服用方便。
Description
技术领域
本发明涉及中药制剂领域，具体的是一种润肠通便丸。
背景技术
便秘是临床上常见的疾病，常表现为大便干结，排便困难，长时间的便秘，常导致痔疮，肛裂。
中医认为：便秘多为素体阳盛胃肠积热。或热病之后余热恶留，下移大肠，过食辛辣食物伤津，或思虑伤脾，肝郁气滞影响脏腑功能，阴血不足，滋润失常，大肠干涩，导致粪便干结，排便困难，血瘀之久集成结块，可伤脉络。
目前临床对于便秘的治疗西医口服果导和纠正菌群失调为主要方法，疗效欠佳。且需长时间服药，易出现药物依赖。
目前临床治疗便秘的中药主要有：
承气汤：组成厚朴4两(去皮)，姜2两(同捣烂，焙干)，大黄2两，枳实半两(麸炒去瓤)，芒硝1两半。
大黄附子汤：附子20克干姜10克肉桂5克萸肉10克白术20克桑螵蛸10克远志10克当归10克吴萸10克肉苁蓉20克。
麻子仁丸：麻子仁500克芍药250克枳实250克(炙)大黄500克(去皮)厚朴250克(炙，去皮)杏仁250克(去皮、尖，熬，别作脂)。
西药治疗需长时间服药，停药极易复发，长时间服药易出现药物依赖，且会造成集体损害。承气汤以泄热、攻积、下气破结为主，而养阴敛津、养血，滋脾润肠不足。大黄附子汤：以滋脾润肠，养血、活血为主、泄热攻积通便不足。麻子仁丸：方中麻子仁润肠通便为君；杏仁降气润肠，芍药养阴和营为臣；枳实、厚朴消痞除满，大黄泻下通便，共为佐使。而养血、活血，化痔消结，降燥不足。
发明内容
针对上述问题，本发明提供一种新的润肠通便丸，该润肠通便丸具有泄热导滞、润肠通便，化痔散结的功效，可标本兼治，对症治疗性强，制作简单，可一次性大批量生产，成药制剂携带服用方便。
根据便秘的机制，辨证施治，采用纯中药组方而成该润肠通便丸，其成分为：熟大黄40g、火麻仁40g、肉苁蓉48g、郁李仁40g、厚朴24g、枳实48g、当归48g、熟地40g、牛膝40g、地榆40g、白芍40g、川芎40g。
该润肠通便丸的制备方法：按量取方中各药，60℃烘干，混匀，粉碎成细末，过6号筛，混匀，每100g加炼蜜110g，合成滋润，团块、搓条、制丸，9g/丸。经环氧乙烷灭菌，无菌室内静止7～10天，检验合格后分装。
给药方法：每次服用9g/丸，每日3次，4周为一疗程，孕妇忌用。
1、熟大黄
苦寒。归脾、胃、大肠、肝、心包经。泻热通肠，凉血解毒，逐瘀通经。用于实热便秘，积滞腹痛，泻痢不爽，湿热黄疸，血热吐衄，目赤，咽肿，肠痈腹痛，痈肿疔疮，瘀血经闭，跌打损伤，外治水火烫伤。
2、火麻仁
味甘、性平，有小毒，归脾、胃、大肠经；质润通降；具有润燥滑肠，利水通淋，活血祛风的功效；主治肠燥便秘，水肿，脚气，热淋，皮肤风痹，月经不调，疮癣，丹毒。
3、肉苁蓉
味甘；咸；性温。归经归肾、大肠经。补肾阳；益精血；润肠道。主肾阳虚衰；精血不足之阳痿；遗精；白浊；尿频余沥；腰痛脚弱；耳鸣目花；月经衍期；宫寒不孕；肠燥便秘。
4、郁李仁：
辛、苦、甘，平。归脾、大肠、小肠经。润燥滑肠，下气，利水。用于津枯肠燥、食积气滞、腹胀便秘、水肿、脚气、小便不利。具有润燥滑肠，下气行滞，利水消肿的功效。
5、厚朴：
苦；辛；性温。归脾经、胃经、大肠经。行气消积；燥湿除满；降逆平喘。主治：食积气滞；腹胀便秘；湿阻中焦，脘痞吐泻；痰壅气逆；胸满喘咳。
6、枳实
苦；辛；寒。归脾；胃；肝；心经。功效主治：积滞内停；痞满胀痛；大便秘结；泻痢后重；结胸；胃下垂；子宫脱垂；脱肛。
7、当归
味甘而重，故专能补血，其气轻而辛，故又能行血，补中有动，行中有补，为血中之要药。因而，它既能补血，又能活血，既可通经，又能活络。凡妇女月经不调，痛经，血虚闭经，面色萎黄，衰弱贫血，子宫出血，产后瘀血，例经(月经来潮时，出现口鼻流血)等妇女的常见病，都可以用当归治疗。
8、熟地
甘，微温。归肝、肾经。功效：补血养阴，填精益髓。
9、牛膝
甘、微苦、性平，祛风，利湿，通经，活血。治风湿腰膝疼痛，脚痿筋挛，血淋，尿血，妇女经闭，症瘕。用于经闭症瘕，胞衣不下，关节痹痛，足痿筋挛，尿血血淋，跌扑损伤。
10、地榆
性寒，味苦酸，无毒；归肝、肺、肾和大肠经。有凉血止血，清热解毒，培清养阴,消肿敛疮等功效。
11、白芍
性微寒，味苦、酸。入肝、脾经。养血柔肝，缓中止痛，敛阴收汗。治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下。
12、川穹
味辛，性温。归肝、胆、心包经。主中风入脑头痛，寒痹，筋挛缓急，金创，妇人血闭无子。具有活血行气、行气开郁，法风燥湿，活血止痛。治风冷头痛旋晕，胁痛腹疼，寒痹筋挛，月经不调，经闭，痛经，难产，产后瘀阻块痛，痈疽疮疡。
方中重用火麻仁、郁李仁、肉苁蓉，质润多脂，滋脾润肠，润燥通便为君药；大黄苦寒泄热，攻积通便，白芍养阴敛津，柔肝理脾共为臣药；枳实下气破结，厚朴行气除满，共同加强降泄通便之功，当归、熟地、川穹、地榆养血、活血、止血、化痔消结，合为佐药；蜂蜜润肠去燥，牛膝引诸药下行共为使药。本方润攻结合，且润大于攻，使下不伤正，诸药合用，共奏润肠通便，化痔散结之功。且润大于攻，使下不伤正，诸药合用，共奏润肠通便，化痔散结之功。标本兼治，疗效显著，且停药不复发。
具体实施方式
采用对162例便秘病人给予润肠通便丸治疗，每日2次，每次9g/丸，治疗1月为一疗程，停药3个月判断疗效。
观察指标：1、排便次数；2、粪便干结程度3、便后感觉：排便不快，有痛苦感或便后未尽感。每日排便一次，便软、排便爽快无不尽感，疗效维持3个月以上为治愈，三项均有明显改善，但维持不足3个月为显效；三项中部分有改善，维持不足3个月为有效；服药停药3天后便秘同前为无效。
润肠通便丸治疗便秘病人与麻子仁丸疗效比较
统计学处理P＜0.01，两组有显著差异。
Claims (2)
1.一种润肠通便丸，其特征在于，其成分由熟大黄40g、火麻仁40g、肉苁蓉48g、郁李仁40g、厚朴24g、枳实48g、当归48g、熟地40g、牛膝40g、地榆40g、白芍40g、川芎40g组成。
2.根据权利要求1所述的润肠通便丸的制备方法，其特征在于，所述方法包括步骤：按量取各组分，60℃烘干，混匀，粉碎成细末，过6号筛，混匀，每100g加炼蜜110g，合成滋润，团块、搓条、制丸，9g/丸；经环氧乙烷灭菌，无菌室内静止7～10天；检验合格后分装。
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| CN105362735A (zh) * | 2015-11-08 | 2016-03-02 | 薛学明 | 一种治疗痔疮的药物及其制备方法 |
| CN114306465A (zh) * | 2022-01-18 | 2022-04-12 | 云南省中医医院(云南中医药大学第一附属医院) | 一种治疗肾阳虚型便秘症的中药组合物、制剂与应用 |
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| CN102038789A (zh) * | 2009-10-22 | 2011-05-04 | 天津中新药业集团股份有限公司达仁堂制药厂 | 一种治疗便秘的中药制剂麻仁滋脾丸的质量控制方法 |
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| CN105362735A (zh) * | 2015-11-08 | 2016-03-02 | 薛学明 | 一种治疗痔疮的药物及其制备方法 |
| CN114306465A (zh) * | 2022-01-18 | 2022-04-12 | 云南省中医医院(云南中医药大学第一附属医院) | 一种治疗肾阳虚型便秘症的中药组合物、制剂与应用 |
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