CN104857001B - A kind of external preparation for treating tinea pedis and preparation method thereof - Google Patents
A kind of external preparation for treating tinea pedis and preparation method thereof Download PDFInfo
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- CN104857001B CN104857001B CN201510216795.4A CN201510216795A CN104857001B CN 104857001 B CN104857001 B CN 104857001B CN 201510216795 A CN201510216795 A CN 201510216795A CN 104857001 B CN104857001 B CN 104857001B
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Abstract
The invention discloses a kind of external preparation for treating tinea pedis, it is made up of aminopyrine, phenacetin, caffeine, phenobarbital and auxiliary material.The present invention can effectively reduce foot fungi and produce, and eliminate fungal infection, antalgesic-antipruritic, eliminating foot smell gas, take effect rapid, cure rate is high, and is not easy recurrent exerbation, has no toxic side effect.
Description
Technical field
The present invention relates to a kind of external preparation for treating tinea pedis and preparation method thereof, belong to the field of medicine technology.
Background technology
Tinea pedis (popular name " athlete's foot ", tinea pedis), is that fungal infection causes, and its skin lesion is often first unilateral (i.e. single pin)
Occur, just offside is arrived in infection after several weeks or several months.The skin lesion of tinea pedis has a feature, i.e. clear border, can be gradually to extending out
Exhibition.Because of disease development or scratching, rotten to the corn, sepage is may occur in which, even, there is warts etc. in bacterium infection.Tinea pedis is by pathogenic true
Microbial foot dermatosis, there is infectiousness.Tinea pedis is popular in the whole world, more general in subtropical and tropical zones
Time.In China, the incidence of disease of tinea pedis is also at a relatively high.There is no sebaceous glands between the vola of people and toe, it is thread so as to lack suppression skin
The aliphatic acid of fungi, physiological defense function is poor, and the sweat gland of skin at these positions is very abundant, perspires relatively more, in addition empty
The air-flow general character is poor, local damp warm, is advantageous to the growth of filamentous fungi.Local epidermis moistening is shown as, invades to burst and turns white, from often
Itching.Often because scratching rubs, cuticular breakdown, peelings and expose the rotten to the corn face of flush, now then sufferings and have scorching hot pain, divide
Secretion has off-odor, the disease also easily scabies secondary infection because of scratching.The course of disease is slow, is not cured for many years generally, and itch unbearably, influences
Fall asleep, influence physical and mental health.In addition, vola position keratoderma is thicker, the keratin in cuticula is the abundant battalion of fungi
Material is supported, is advantageous to the growth of fungi.The tinea pedis incidence of disease is high, has had a strong impact on the normal life of patient.
Therefore, invention one kind can effectively reduce foot fungi and produce, and can also eliminate high outer of fungal infection, cure rate
Had important practical significance with preparation.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of external preparation for treating tinea pedis and preparation method thereof.This
The described external preparation of invention can effectively reduce foot fungi and produce, elimination fungal infection, antalgesic-antipruritic, eliminating foot smell gas,
Take effect rapid, cure rate is high.
In order to solve the above technical problems, technical scheme is as follows：
A kind of external preparation for treating tinea pedis, is calculated according to composition by weight, by aminopyrine 2-50 parts, phenacetin 2-50
Part, caffeine 1-30 parts, phenobarbital 0.2-8 parts and auxiliary material are made.
In the external preparation of foregoing treatment tinea pedis, calculated according to composition by weight, by aminopyrine 5-30 parts, phenacetin
5-40 parts, caffeine 2-20 parts, phenobarbital 0.5-5 parts and auxiliary material are made.
In the external preparation of foregoing treatment tinea pedis, calculated according to composition by weight, by 15 parts of aminopyrine, phenacetin 20
Part, 10 parts of caffeine, 3 parts of phenobarbital and auxiliary material are made.
The preparation method of the external preparation of foregoing treatment tinea pedis, take aminopyrine, phenacetin, caffeine and benzene bar ratio
It is appropriate, customary adjuvant is added, auxiliary material can also be not added with, be processed according to routine techniques, traditional drug formulations are made, produced.
In the preparation method of the external preparation of foregoing treatment tinea pedis, the pharmaceutical preparation is powder or ointment.
In the preparation method of the external preparation of foregoing treatment tinea pedis, the powder is prepared：Each medicinal powder is broken into carefully
Powder, it is well mixed, packing, produces after sieving.
In the preparation method of the external preparation of foregoing treatment tinea pedis, the powder is prepared：Each medicinal powder is broken into carefully
Powder, it is well mixed with 0.2-5 times of starch measured of medicine total amount, dispenses, produce.
Specifically, the powder is prepared：Each medicinal powder is broken into fine powder, mixed with the starch of 0.5 times of amount of medicine total amount
Close uniformly, packing, produce.
In the preparation method of the medicine of foregoing treatment tinea pedis, the ointment is prepared：Each medicinal powder is broken into 200-
The powder of 300 mesh, it is well mixed after sieving, it is standby；Separately take medicine gross weight 5-15% sorbierite, 5-15% glycerine, 4-
12% stearic acid, 2-8% yellow petroleum jelly, the 5-15% lanolin of poly- sorb fat 80 and 1-5% are heated to 80 DEG C, make to melt
Melt, 10-30 minutes are emulsified after being mixed with above-mentioned medicinal powder, it is 70-90 DEG C of insulation 20-50 minute, filling, produce.
Specifically, the ointment is prepared：Each medicinal powder is broken into the powder of 200-300 mesh, is well mixed after sieving,
It is standby；The another sorbierite for taking medicine gross weight 10%, 10% glycerine, 8% stearic acid, 5% yellow petroleum jelly, 10% it is poly-
The lanolin of sorb fat 80 and 3% is heated to 80 DEG C, makes melting, is emulsified after being mixed with above-mentioned medicinal powder 15 minutes, 80 DEG C of insulations 30
Minute, it is filling, produce.
External preparation of the present invention is mainly made up of aminopyrine, phenacetin, caffeine and phenobarbital.Wherein,
Aminopyrine also known as pyramidon, Pyramidon, Amidozon, Aminophenazon, Aminopyrine, replaced by amino peace
Obtained than woods through catalytic hydrogenation (hydrocarbonylation), the synthesis and release of prostaglandin in inflammation local organization, stable lysosome can be suppressed
Enzyme, influence the phagocytosis of phagocyte and play antiinflammatory action, also made by suppressing the synthesis of prostaglandin etc. to play analgesia
With.Phenacetin is also known as Acetophenetidin.Glossiness small lobate or flake-like crystal, odorless, mildly bitter flavor.It is steady in atmosphere
It is fixed, it is atomic to be dissolved in water, boiling water is slightly soluble in, is slightly soluble in ether, is dissolved in ethanol, chloroform.By paranitrochlorobenzene it is etherified, reduction and second
Acylation reaction is made.For acetophenone amine antipyretic-antalgic agent.Suitable for having a fever, having a headache, neuralgia etc..Can be by suppressing prostate
The synthesis of element etc. and rise analgesic activity.Caffeine is a kind of xanthine alkaloid compound, is central nervous excitation agent, can be temporary
When drive away sleepiness and regain one's vigor.The excited cerebral cortex of energy, improves the irritability to the external world, and has the contraction cerebrovascular, strengthens
First three medicine alleviates the effect of headache.Phenobarbital has calmness, hypnosis, anticonvulsant action, can strengthen aminopyrine and Fei Naxi
The analgesic activity of fourth.Phenobarbital is used for:It is 1. calm:Such as anxious, irritated, hyperthyroidism, hypertension, feature
The diseases such as nausea, children's pyloric spasm；2. hypnosis:It is even to be used for obstinate asomnia, but often there is rear lose such as tired, drowsiness to imitate after waking up
Should；It is 3. anticonvulsion:Commonly use it and resist and fainted from fear caused by the disease such as nervous stimulant poisoning or high fever, lockjaw, encephalitis, cerebral hemorrhage；
4. anti-epileptic:For grand mal and the treatment of partial seizures, appearance effect is fast, it can also be used to status epilepticus；⑤
Preanesthetic medication；6. with analgesic-antipyretic compatibility application, to strengthen its effect；7. treat hyperbilirubinemia of newborn.
Said medicine is applied in combination the present invention, can effectively reduce foot fungi and produce, eliminate fungal infection, analgesic stops
Itch, eliminating foot smell gas, take effect rapid, and cure rate is high, is not easy recurrent exerbation, has no toxic side effect.
Applicant has carried out substantial amounts of experimental study to the external preparation of the present invention for controlling tinea pedis, as a result as follows：
Experimental example 1.Ear swelling test is studied
Medicine：
1.1 powders (prepared by the method according to the embodiment of the present invention 1) of the present invention.
1.2 control drug group:1：
Prescription：15 parts of aminopyrine, 15 parts of phenacetin, 5 parts of caffeine.
Technique：Each medicinal powder is broken into fine powder, is well mixed, produces after sieving.
1.3 control drugs 2：
Prescription：15 parts of aminopyrine, 20 parts of phenacetin, 10 parts of caffeine
Technique：Each medicinal powder is broken into fine powder, is well mixed, produces after sieving.
1.4 control drug groups 3：
Prescription：15 parts of aminopyrine, 15 parts of phenacetin, 5 parts of caffeine, 1.5 parts of phenobarbital.
Technique：Each medicinal powder is broken into fine powder, is well mixed, produces after sieving.
Experimental method
Taking Kunming mouse 50, male and female dual-purpose is randomly divided into 5 groups, packet, administration, gives corresponding medicine, and daily 1
It is secondary, continuous 5d.Last dose 30min, each group mouse uniformly smears dimethylbenzene 0.03mL/ only respectively at auris dextra, after 40min, place
Dead animal, clip or so ear, auricle is laid in same position with 8mm card punch, precision claims quality, a left side is subtracted with auris dextra tablet quality
Auricle quality is the mice auricle swelling degree.As a result such as table 1.
The paraxylene of table 1 causes the influence (x ± s, n=11) of mice auricle swelling
Compared with blank group：*P ＜ 0.05；**P ＜ 0.01；
Compared with control drug group 1：^P ＜ 0.05；
Compared with 2 groups of control drug：#P ＜ 0.05；
Compared with 3 groups of control drug：&P ＜ 0.05；
3. experimental result：As seen from Table 1, the present invention can significantly mitigate mice auricle swelling degree, and it is anti-acute to show that it has
The effect of inflammation.And curative effect is better than control drug group 1, control group 2 and control group 3.
Experimental example 2.Clinic Case
1. medicine：Powder (prepared by the method according to the embodiment of the present invention 1) of the present invention, reference substance (clotrimazole, city
Sell).
2.240 are out-patient, wherein present invention group and each 120 of clotrimazole group, I 60, type, II 64, type, III
56, type, IV 60, type；It is 7~65 years old age, the most common with 18~45 years old；The course of disease is most long 8 years, most short 1 month.
3. treatment method：Powder of the present invention is smeared at the Tu Yu volas infection of vola, is separately taken and is placed on a small quantity in footwear；Clotrimazole gram
Mould azoles is smeared at the Tu Yu volas infection of vola, once a day；Continuous treatment 10d is 1 course for the treatment of.It is discontinued after one week, then observes hair
Make situation.
4. diagnostic criteria：
Foot odour, pin sweat (I type)：The more phenomenons of foot odour, pin sweat disappear to cure；The more phenomenons of foot odour, pin sweat mitigate to take a turn for the better；Disease
Shape is not obviously improved to be invalid；
Pompholyx type tinea pedis (II type)：Disappeared between hidrosis, itch, toe phenomena such as raw vesicle, interphalangeal erosion stream yellow water to control
More；It is improvement that itch, interphalangeal erosion stream yellow water phenomenon, which mitigate, and it is invalid that symptom and sign are not substantially changed into；
Angling desquamative tinea pedis (III type):Dry skin, angling furfur, so that expose soft textive, winter chap phenomena such as disappear
Lose to cure；Phenomena such as chap, itch, mitigates to take a turn for the better；It is invalid that symptom and sign are not substantially changed into；
Type tinea pedis (IV type) between toe：The symptoms such as toe seam turns white, flowing water is rotten to the corn, very itches disappear, and functional rehabilitation is to cure；Symptom
Obvious to mitigate, function is had a certain recovery to take a turn for the better；Symptom does not substantially mitigate, and movable function is limited as invalid.
5. according to above-mentioned standard, treatment results such as table 2 and table 3.
Table 2
Table 3
As a result show, medicine of the present invention is suitable with clotrimazole to the obvious therapeutic effect that has of tinea pedis, curative effect.Medication
Do not find that patient has any adverse reaction after period and medication, it is non-stimulated to skin.It is discontinued after two weeks, uses medicine of the present invention
Only 2 breaking-outs, attack rate 2.27% in 88 patients cured.There are 4 breaking-outs in 79 patients cured in clotrimazole group,
Attack rate is 5.06%.The attack rate of medicine of the present invention is less than clotrimazole group.
Compared with prior art, the present invention is made and controlled from aminopyrine, phenacetin, caffeine and phenobarbital combination
The external preparation of tinea pedis is treated, foot fungi can be effectively reduced and produce, eliminate fungal infection, antalgesic-antipruritic, eliminating foot smell gas.System
Into external preparation take effect rapidly, cure rate is high, evident in efficacy, and is not easy recurrent exerbation, has no toxic side effect, has reached invention mesh
's.
Embodiment：
Embodiment 1：
Prescription：Aminopyrine 15g, phenacetin 20g, caffeine 10g, phenobarbital 3g.
Technique：Each medicinal powder is broken into fine powder, is well mixed after sieving, packing, produces powder.
Usage：External application.Affected part is applied to, it is daily 2-3 times.
Embodiment 2：
Prescription：Aminopyrine 2g, phenacetin 2g, caffeine 1g, phenobarbital 0.2g.
Technique：Each medicinal powder is broken into fine powder, is well mixed with 2.6g starch, dispenses, produces powder.
Usage：External application.Affected part is applied to, it is daily 2-3 times.
Embodiment 3：
Prescription：Aminopyrine 50g, phenacetin 50g, caffeine 30g, phenobarbital 8g.
Technique：Each medicinal powder is broken into the powder of 200-300 mesh, is well mixed after sieving, it is standby；The another sorbierite for taking 13.8g,
13.8g glycerine, 11.04g stearic acid, 6.9g yellow petroleum jelly, the 13.8g lanolin of poly- sorb fat 80 and 4.14g add
Heat makes melting to 80 DEG C, is emulsified after being mixed with above-mentioned medicinal powder 15 minutes, 80 DEG C are incubated 30 minutes, filling, produce ointment.
Usage：External application.Affected part is applied to, it is daily 2-3 times.
Claims (5)
- A kind of 1. external preparation for treating tinea pedis, it is characterised in that：Calculated according to composition by weight, by 15 parts of aminopyrine, it is non-that Western 20 parts of fourth, 10 parts of caffeine, 3 parts of phenobarbital and auxiliary material are made.
- A kind of 2. preparation method of the external preparation for the treatment of tinea pedis as claimed in claim 1, it is characterised in that：Take amino ratio Woods, phenacetin, caffeine and phenobarbital, customary adjuvant is added, is processed according to routine techniques, conventional medicine system is made Agent, produce.
- 3. the preparation method of the external preparation for the treatment of tinea pedis as claimed in claim 2, it is characterised in that：The pharmaceutical preparation is Powder or ointment.
- 4. the preparation method of the external preparation for the treatment of tinea pedis as claimed in claim 3, it is characterised in that：The powder is so made It is standby：Each medicinal powder is broken into fine powder, is well mixed with 0.2-5 times of starch measured of medicine total amount, dispenses, produces.
- 5. the preparation method of the external preparation for the treatment of tinea pedis as claimed in claim 3, it is characterised in that：The ointment is so Prepare：Each medicinal powder is broken into the powder of 200-300 mesh, is well mixed after sieving, it is standby；The another sorb for taking medicine gross weight 5-15% Alcohol, 5-15% glycerine, 4-12% stearic acid, 2-8% yellow petroleum jelly, the 5-15% lanolin of poly- sorb fat 80 and 1-5% add Heat makes melting to 80 DEG C, and 10-30 minutes are emulsified after being mixed with above-mentioned medicinal powder, 70-90 DEG C of insulation 20-50 minute, filling, produces.
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| 去痛片巧治疗脚气;cbaabc6;《网址为http://wenku.baidu.com/link?url=IzJ33PVpljK2c3ctirH63EXhTR6VQgn0jWAKskr5AsjRupa33k8kZiIi9JAVfRHHWEEuWSix1fnkeAA3nTbsYTr-zanIFNpVIs42Wm5r9Di》;20140629;网址：http://wenku.baidu.com/link?url=IzJ33PVpljK2c3ctirH63EXhTR6VQgn0jWAKskr5AsjRupa33k8kZiIi9JAVfRHHWEEuWSix1fnkeAA3nTbsYTr-zanIFNpVIs42Wm5r9Di * |
| 绿豆煮鸡蛋，可治口角炎;小咪22;《网址为bbs.tianya.cn/post-413-97028-1.shtml》;20130128;网址为bbs.tianya.cn/post-413-97028-1.shtml * |
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