CN104856781B - Experimental animal sootiness modeling case and its modeling method - Google Patents
Experimental animal sootiness modeling case and its modeling method Download PDFInfo
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- CN104856781B CN104856781B CN201510335138.1A CN201510335138A CN104856781B CN 104856781 B CN104856781 B CN 104856781B CN 201510335138 A CN201510335138 A CN 201510335138A CN 104856781 B CN104856781 B CN 104856781B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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Abstract
The invention discloses a kind of experimental animal sootiness modeling case and its modeling method, including experimental animal sootiness modeling case, including sootiness modeling case, sootiness monitor box, pumping rod, smokescope survey meter, ventilation mouth, fan and lid；Sootiness monitor box is arranged in sootiness modeling case, and sootiness monitor box is made up of sootiness groove and box detector, and smokescope survey meter is arranged in box detector, and the cigarette lighted is inserted in sootiness groove；Ventilation mouth is arranged on the opposite side of sootiness modeling case, and fan insertion is arranged on ventilation mouth；On the upper surface of sootiness modeling case, the lower end of pumping rod is inserted in sootiness modeling case, and is connected with sootiness monitor box, and the upper end of pumping rod extends to the top of sootiness modeling case through lid for lid insertion.The present invention is simple to operate, cheap, and smokescope can be made more homogeneous, and smokescope can at any time be monitored and adjust；Can the more standardized preparation for carrying out experimental animal COPD models；Modeling success rate is high.
Description
Technical field
The present invention relates to medical technology experiment field, more particularly to a kind of experimental animal sootiness modeling case and its modeling side
Method.
Background technology
Current sootiness modeling method mainly has mouth and nose formula exposure system and whole-body type exposure system；Mouth and nose formula exposure system is adopted
Use tower cavity structure, exposure storehouse its aeration of formula system and gaseous mass are poor, be difficult to carry out gas precision data monitoring and
Regulation；It is not easy to clean and reuse, easy waste of resource and not environmentally；Modeling success rate is low, it is impossible to enough Real Time Observation experiments
During animal active situation.
The content of the invention
The purpose of the present invention：A kind of experimental animal sootiness modeling case and its modeling method are provided, for chronic obstructive pulmonary
The preparation of disease (chronic obstructive pulmonary disease, abbreviation COPD) animal model, cures for basis
Learn relevant animal experiment.
To achieve these goals, the technical scheme is that：
A kind of experimental animal sootiness modeling case, including the detection of sootiness modeling case, sootiness monitor box, pumping rod, smokescope
Instrument, ventilation mouth, fan and lid；Described sootiness modeling case is the body structure of closing, four of described sootiness modeling case
Side is free relief surface；Described sootiness monitor box is arranged in described sootiness modeling case, positioned at described sootiness modeling
The middle part of case, described sootiness monitor box is made up of sootiness groove and box detector, and described sootiness groove is arranged on described detection
The top of device box, described smokescope survey meter is arranged in described box detector, and the cigarette lighted is inserted in described
In sootiness groove；Described ventilation mouth is arranged on the opposite side of described sootiness modeling case, positioned at the bottom of described sootiness modeling case
Portion, described fan insertion is arranged on described ventilation mouth；Described lid insertion is arranged on described sootiness modeling case
On upper surface, positioned at the top of described sootiness monitor box；The lower end of described pumping rod is inserted in described sootiness modeling case
It is interior, and be connected with described sootiness monitor box, the upper end of described pumping rod extends to described sootiness through described lid
The top of modeling case.
Above-mentioned experimental animal sootiness modeling case, wherein, it is respectively equipped with multiple in described sootiness modeling case and active face
Air vent, described air vent is centered around around described sootiness groove.
Above-mentioned experimental animal sootiness modeling case, wherein, described air vent and ventilation mouth pass through preservative film or sealing-plug
Sealing.
Above-mentioned experimental animal sootiness modeling case, wherein, described sootiness modeling case by waterproof fireproofing transparent high temperature resistant
Material is made.
Above-mentioned experimental animal sootiness modeling case, wherein, the outside of described fan is provided with adsorption box, described adsorption box
It is flexibly connected with described sootiness modeling case, activated carbon is provided with the outboard end of described adsorption box.
A kind of modeling method of experimental animal sootiness modeling case, the method at least comprises the following steps：
Step 1：The cigarette lighted is put into described sootiness groove.
Step 2：Described smokescope survey meter is installed in described sootiness modeling case and is opened, concurrently set mesh
Mark concentration value and alarming value.
Step 3：The concentration of described smokescope survey meter monitoring carbon monoxide, sulfur dioxide and oxygen.
Step 4：After carbon monoxide, sulfur dioxide and oxygen reach aimed concn in described sootiness modeling case, institute is opened
The fan on ventilation mouth stated.
Step 5：The wind speed of the described fan of regulation, makes carbon monoxide, sulfur dioxide and oxygen in described sootiness modeling case
Gas concentration is maintained in target zone.
Step 6：Experimental animal is put into described sootiness modeling case carries out sootiness modeling experiment, after the completion of take out.
Step 7：Described fan is closed after the smog in described sootiness modeling case is drained.
The present invention it is simple to operate, it is cheap, smokescope can be made more homogeneous, smokescope can be monitored at any time and
Regulation；Can the more standardized preparation for carrying out experimental animal COPD models；Modeling success rate is high.
Brief description of the drawings
Fig. 1 is the structural representation of experimental animal sootiness modeling case of the present invention.
Fig. 2 is the flow chart of the modeling method of experimental animal sootiness modeling case of the present invention.
Specific embodiment
Embodiments of the invention are further illustrated below in conjunction with accompanying drawing.
Refer to shown in accompanying drawing 1, a kind of experimental animal sootiness modeling case, including sootiness modeling case 1, sootiness monitor box 2, take out
Pull bar 3, smokescope survey meter 4, ventilation mouth 5, fan 6 and lid 7；Described sootiness modeling case 1 is the body structure of closing,
Four sides of described sootiness modeling case 1 are free relief surface；Described sootiness monitor box 2 is arranged on described sootiness modeling
In case 1, positioned at the middle part of described sootiness modeling case 1, described sootiness monitor box 2 is made up of sootiness groove 21 and box detector,
Described sootiness groove 21 is arranged on the top of described box detector, and described smokescope survey meter 4 is arranged on described spy
Survey in device box, the cigarette lighted is inserted in described sootiness groove 21；Described ventilation mouth 5 is arranged on described sootiness modeling case
1 opposite side, positioned at the bottom of described sootiness modeling case 1, the described insertion of fan 6 is arranged on described ventilation mouth 5；Institute
The insertion of lid 7 stated is arranged on the upper surface of described sootiness modeling case 1, positioned at the top of described sootiness monitor box 2；Institute
The lower end of the pumping rod 3 stated is inserted in described sootiness modeling case 1, and is connected with described sootiness monitor box 2, and described takes out
The upper end of pull bar 3 extends to the top of described sootiness modeling case 1 through described lid 7.
Multiple air vents 8 are respectively equipped with described sootiness modeling case 1 and active face 2, described air vent 8 is centered around institute
Around the sootiness groove 3 stated.
Described air vent 8 and ventilation mouth 5 can be sealed by preservative film or sealing-plug, keep the envelope of sootiness modeling case 1
Close, also can cause low-oxygen environment by air vent 8 to nitrogen is filled with for reducing oxygen concentration in sootiness modeling case 1.
Described sootiness modeling case 1 is made up of the transparent high temperature resistant material of waterproof fireproofing.Free relief surface can be dismantled freely,
It is easy to modeling experiment to clear up environment in sootiness modeling case 1 after terminating, reuses it.
The outside of described fan 6 is provided with adsorption box 9, and described adsorption box 9 is with the described activity of sootiness modeling case 1 even
Connect, activated carbon 10 is provided with the outboard end of described adsorption box 9, for adsorbing flue dust.Activated carbon 10 can use car tail aspiration
Attached activated carbon, using more environmentally friendly, adsorption box 9 can be dismantled.
The present invention can be lifted sootiness monitor box 2 by pumping rod 3, be easy to deposit cigarette and smokescope survey meter 4.
Refer to shown in accompanying drawing 2, a kind of modeling method of experimental animal sootiness modeling case, the method at least includes following step
Suddenly：
Step 1：The cigarette lighted is put into described sootiness groove 3.
Step 2：Described smokescope survey meter 4 is installed in described sootiness modeling case 1 and is opened, concurrently set
Target concentration value and alarming value.Aimed concn and alarming value can need setting by experiment operator according to different experiments.
Step 3：Described smokescope survey meter 4 monitors the concentration of carbon monoxide, sulfur dioxide and oxygen etc..
Step 4：After carbon monoxide, sulfur dioxide and oxygen reach aimed concn in described sootiness modeling case 1, institute is opened
The fan 6 on ventilation mouth 5 stated.
Step 5：The wind speed of the described fan 6 of regulation, make carbon monoxide in described sootiness modeling case 1, sulfur dioxide and
Oxygen concentration is maintained in target zone.The target zone of carbon monoxide and sulfur dioxide concentration is by experiment operator according to not
Same experiment needs setting.
Step 6：Experimental animal is put into described sootiness modeling case 1 carries out sootiness modeling experiment, after the completion of take out.It is real
The smoke fumigating time that animal is put into sootiness modeling case 1 is tested to be adjusted and determined in practical operation by experiment operator.
Step 7：Described fan 6 is closed after the smog in described sootiness modeling case 1 is drained.
The present invention is the modeling Smoke fumigating box of experimental animal COPD, and the smokescope of sootiness is controllable, the casing energy of transparent material
Enough clearly observation experiment processes.
In sum, the present invention is simple to operate, cheap, can make that smokescope is more homogeneous, and smokescope can be at any time
It is monitored and adjusts；Can be with Real Time Observation animal activity situation by transparent cabinet；More standardized can carry out experiment dynamic
The preparation of thing COPD models；Modeling success rate is high.
The preferred embodiments of the present invention are the foregoing is only, the scope of the claims of the invention, every utilization is not thereby limited
The equivalent structure transformation that present specification is made, or directly or indirectly with the technology neck for being attached to other Related products
Domain, is included within the scope of the present invention.
Claims (6)
1. a kind of experimental animal sootiness modeling device, it is characterised in that：Including sootiness modeling case, sootiness monitor box, pumping rod, cigarette
Mistiness degree survey meter, ventilation mouth, fan and lid；Described sootiness modeling case is the body structure of closing, and described sootiness is made
Four sides of moulding box are free relief surface；Described sootiness monitor box is arranged in described sootiness modeling case, positioned at described
Sootiness modeling case middle part, described sootiness monitor box is made up of sootiness groove and box detector, and described sootiness groove is arranged on
The top of described box detector, described smokescope survey meter is arranged in described box detector, and the cigarette lighted is inserted
Enter in described sootiness groove；Described ventilation mouth is arranged on the side of described sootiness modeling case, is made positioned at described sootiness
The bottom of moulding box, described fan insertion is arranged on described ventilation mouth；Described lid insertion is arranged on described sootiness
The upper surface center of modeling case, positioned at the top of described sootiness monitor box；The lower end of described pumping rod is inserted in institute
In the sootiness modeling case stated, and it is connected with described sootiness monitor box, the upper end of described pumping rod is prolonged through described lid
Reach the top of described sootiness modeling case.
2. experimental animal sootiness modeling device according to claim 1, it is characterised in that：Set on described sootiness modeling case
There are multiple air vents, described air vent is centered around around described sootiness groove.
3. experimental animal sootiness modeling device according to claim 2, it is characterised in that：Described air vent and ventilation mouth
Sealed by preservative film or sealing-plug.
4. experimental animal sootiness modeling device according to claim 1, it is characterised in that：Described sootiness modeling case is by preventing
Water fireproof transparent high temperature resistant material is made.
5. experimental animal sootiness modeling device according to claim 1, it is characterised in that：The outside of described fan is provided with
Adsorption box, described adsorption box is flexibly connected with described sootiness modeling case, and activity is provided with the outboard end of described adsorption box
Charcoal.
6. the modeling method of the experimental animal sootiness modeling device described in a kind of utilization claim 1, it is characterised in that：The method
At least comprise the following steps：
Step 1：The cigarette lighted is put into described sootiness groove；
Step 2：Described smokescope survey meter is installed in described sootiness modeling case and is opened, concurrently set target rich
Angle value and alarming value；
Step 3：The concentration of described smokescope survey meter monitoring carbon monoxide, sulfur dioxide and oxygen；
Step 4：After carbon monoxide, sulfur dioxide and oxygen reach aimed concn in described sootiness modeling case, described in opening
Fan on ventilation mouth；
Step 5：The wind speed of the described fan of regulation, makes carbon monoxide, sulfur dioxide and oxygen in described sootiness modeling case dense
Degree is maintained in target zone；
Step 6：Experimental animal is put into described sootiness modeling case carries out sootiness modeling experiment, after the completion of take out；
Step 7：Described fan is closed after the smog in described sootiness modeling case is drained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510335138.1A CN104856781B (en) | 2015-06-17 | 2015-06-17 | Experimental animal sootiness modeling case and its modeling method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510335138.1A CN104856781B (en) | 2015-06-17 | 2015-06-17 | Experimental animal sootiness modeling case and its modeling method |
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| CN104856781A CN104856781A (en) | 2015-08-26 |
| CN104856781B true CN104856781B (en) | 2017-06-27 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105455220B (en) * | 2016-01-08 | 2016-11-30 | 南京市口腔医院 | A kind of device of laboratory animal simulation people actively smoking effect |
| CN106128254A (en) * | 2016-08-31 | 2016-11-16 | 阮峰 | A kind of smoke inhalation injury model equipment |
| CN106781950A (en) * | 2017-01-03 | 2017-05-31 | 中国人民解放军第八医院 | A kind of multi-functional smog for medical research is caused injury experimental facilities |
| CN111742883B (en) * | 2020-01-03 | 2022-02-18 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Construction method of lung and spleen qi deficiency allergic rhinitis combined animal model |
| CN113069240B (en) * | 2021-05-10 | 2024-06-18 | 西安培华学院 | Animal chronic obstructive disease test device and method for smoke recycling |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN204744498U (en) * | 2015-06-17 | 2015-11-11 | 徐向前 | Experimental animals smokes and makes moulding box |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN201404307Y (en) * | 2009-05-19 | 2010-02-17 | 江苏省人民医院 | Animal smoking device |
| CN202654264U (en) * | 2012-04-19 | 2013-01-09 | 宁波大学 | Device for manufacturing animal model of smoking chronic obstructive pulmonary disease |
| CN203042539U (en) * | 2012-12-25 | 2013-07-10 | 北京慧荣和科技有限公司 | Animal full-smoke exposing system |
| CN204274716U (en) * | 2014-08-05 | 2015-04-22 | 中国人民解放军第四军医大学 | A kind of smoke inhalation is caused injury experimental provision |
| CN104306081B (en) * | 2014-11-11 | 2017-06-20 | 黑龙江省中医药科学院 | Rodent respiratory system exposes contamination device |
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| CN204744498U (en) * | 2015-06-17 | 2015-11-11 | 徐向前 | Experimental animals smokes and makes moulding box |
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