CN104306081B - Rodent respiratory system exposes contamination device - Google Patents
Rodent respiratory system exposes contamination device Download PDFInfo
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- CN104306081B CN104306081B CN201410631909.7A CN201410631909A CN104306081B CN 104306081 B CN104306081 B CN 104306081B CN 201410631909 A CN201410631909 A CN 201410631909A CN 104306081 B CN104306081 B CN 104306081B
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- flue tube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
Abstract
Rodent respiratory system exposes contamination device, belongs to a kind of contamination device.The present invention is complicated in order to solve existing smoke exposure apparatus structure, and volume is big, and smoke collection part and sootiness part are integrated, and easily causes the problem of experimental animal scald.Rodent respiratory system of the present invention exposes contamination device, including smoke collection case, flue tube and fumigation case, and smoke collection case and fumigation case are connected by flue tube, reduce the heat produced in cigarette combustion smog, make the temperature in fumigation case constant.Small volume of the present invention, capacity is big, can simultaneously test modeling to many experiments animal, reduces group difference and other environmental disturbances.And ensure the gregarious habit of experimental animal, simulate the normal life environment of animal, without constraint, animal is in the state of freely activity, so as to obtain more accurately test acceptor.
Description
Technical field
The invention belongs to a kind of contamination device, more particularly to a kind of exposed contamination device of animal breath system.
Background technology
The experiment of experimental animal gas exposure is the basic skills of gas toxicity assessment, and experimental animal gas exposure device is this
Important stage property in experiment, can be used for simulating by the toxic condition of inhalation exposure, be widely used in environmental protection, industry
In health, drug research and toxicity Journal of Sex Research.But existing smoke exposure apparatus structure is complicated, volume is big, smoke collection part
It is integrated with sootiness part, easily causes experimental animal scald, non-uniform temperature, environment disunity causes experiment acceptor to produce poor
It is different.
The content of the invention
The present invention is complicated in order to solve existing smoke exposure apparatus structure, and volume is big, smoke collection part and sootiness portion
It is divided into one, easily causes the problem of experimental animal scald, rodent respiratory system exposure contamination device is now provided.
Rodent respiratory system exposes contamination device, and it includes：Smoke collection case, flue tube and fumigation case；Smog
The outlet flue of vasculum is connected by flue tube with the smoke inlet of fumigation case.
Above-mentioned flue tube is provided with n turning, n be more than or equal to positive integer.
Separation net is provided with the smoke inlet of above-mentioned fumigation case.
Above-mentioned rodent respiratory system exposure contamination device also includes：Dissipate cigarette plate；Dissipate and m scattered cigarette is provided with cigarette plate
Hole, wherein m are positive integer；Dissipate cigarette plate and be fixed on fumigation case interior lower end.
Above-mentioned rodent respiratory system exposure contamination device also includes：Rotating disk, protection network and motor；Rotating disk is hollow
Structure, and surface is provided with aperture, the outlet flue of flue tube is connected with the axle center of rotating disk, and is to turn between flue tube and rotating disk
Dynamic connection, motor is rotated for driving rotating disk, and protection network is fixed on rotating disk top.
The top of fumigation case or the top of side wall are provided with exhaust outlet.
Above-mentioned rodent respiratory system exposure contamination device also includes：Ventilating fan, ventilating fan is fixed on fumigation case
At square exhaust outlet, motor is used to drive ventilating fan to rotate.
Rodent respiratory system exposes contamination device, and it includes：Flue tube, fumigation case, two unidirectional baffle plate, threeways
Structure, piston and cigarette holder；
The smoke inlet of fumigation case is connected with the outlet flue of flue tube；
The port of piston connects with a port of three-port structure, the second port of the three-port structure and the smoke of cigarette holder
Mouth is connected, and the 3rd port of the three-port structure is connected with the smoke inlet of flue tube；
A unidirectional baffle plate is provided between the three-port structure and the outlet flue of cigarette holder, the unidirectional baffle plate is only capable of direction
Three-port structure side is opened,
Be provided with a unidirectional baffle plate between the three-port structure and the smoke inlet of flue tube, the unidirectional baffle plate be only capable of to
Flue tube side is opened,
Piston can move reciprocatingly in a port of three-port structure；
The smoke absorbing end of cigarette is inserted on cigarette holder.
Rodent respiratory system exposes contamination device, it is characterised in that it includes：Flue tube, fumigation case, two lists
To valve, three-port structure, piston and cigarette holder；
The smoke inlet of fumigation case is connected with the outlet flue of flue tube；
The port of piston connects with a port of three-port structure, the second port of the three-port structure and the smoke of cigarette holder
Mouth is connected, and the 3rd port of the three-port structure is connected with the smoke inlet of flue tube；
A check valve is provided between the three-port structure and the outlet flue of cigarette holder, the check valve is only capable of towards threeway
Structure side is opened,
A check valve is provided between the three-port structure and the smoke inlet of flue tube, the check valve is only capable of to flue
Pipe side is opened,
Piston can move reciprocatingly in a port of three-port structure；
The smoke absorbing end of cigarette is inserted on cigarette holder.
Rodent respiratory system of the present invention exposes contamination device, including smoke collection case, flue tube and smoked
Smoke box, smoke collection case and fumigation case are connected by flue tube, reduce the heat produced in cigarette combustion smog, are made in fumigation case
Temperature it is constant.
The present invention controls the suction of smog by piston, simulates human body smoking process, can make cigarette burn incompletely, produces
With mankind's smoking identical composition, at utmost close to human disease's environment.Smog is discharged at regular time and quantity by controlled motor,
Make smokescope controllable.Ensure that smokescope is constant in fumigation case by ventilating fan, while ensureing oxygen turnover.By rotating disk and
Dissipate cigarette plate to be uniformly spread in smog in whole fumigation case, it is ensured that full of the smog of lasting and equilibrium concentration in fumigation case, make cigarette
Mist is dispersed in each portion of casing, reaches environment unification, reduces group difference.
Small volume of the present invention, capacity is big, can simultaneously test modeling to many experiments animal, reduces group difference and other rings
Disturb in border.And ensure the gregarious habit of experimental animal, simulate the normal life environment of animal, without constraint, be in animal
The state of free activity, so as to obtain more accurately test acceptor.The present invention is caused by smog long-time stimulation test animal
Experimental animal respiratory disease, is mainly used in experimental animal chronic bronchitis model or coordinates other experiment materials to cause
COPD (COPD) animal model.
Brief description of the drawings
Fig. 1 is the sectional view of the rodent respiratory system exposure contamination device described in specific embodiment one；
Fig. 2 is that the electrical structure of the rodent respiratory system exposure contamination device described in specific embodiment one is illustrated
Figure；
Fig. 3 is the sectional view of the rodent respiratory system exposure contamination device described in specific embodiment ten；
Fig. 4 is that the electrical structure of the rodent respiratory system exposure contamination device described in specific embodiment ten is illustrated
Figure.
Specific embodiment
Specific embodiment one：Present embodiment, the rodent described in present embodiment are illustrated referring to Figures 1 and 2
Animal breath system exposes contamination device, and it includes：Smoke collection case 2, flue tube 3 and fumigation case 6；
The outlet flue of smoke collection case 2 is connected by flue tube 3 with the smoke inlet of fumigation case 6.
Contamination device described in present embodiment is divided into three parts, by flue tube 3 by smoke collection case 2 and fumigation case
6 are connected, in practical application, cigarette 1 is lighted being positioned in smoke collection case 2, smog is conveyed after flue tube 3 is transmitted
To fumigation case 6, smog distributes heat in the transmitting procedure of flue tube 3, can effectively reduce the temperature of smog, so as to prevent
Animal for research is burned in fumigation case 6, it is also possible to ensure the constant of temperature in fumigation case 6, prevents due to the inside of fumigation case 6 temperature
Spend influence test effect high.Meanwhile, for the ease of placing experimental animal, sliding door is additionally provided with the side wall of fumigation case 6.
Specific embodiment two：Present embodiment is sudden and violent to the rodent respiratory system described in specific embodiment one
Dew contamination device is described further, and in present embodiment, the flue tube 3 is provided with n turning, and n is just whole more than or equal to 3
Number.
Smog is transmitted in the n flue tube at turning 3 is provided with, and can allow smog that heat is fully distributed in flue tube 3, is protected
The smog temperature that card enters in fumigation case 6 is identical with room temperature.
Specific embodiment three：Present embodiment is sudden and violent to the rodent respiratory system described in specific embodiment one
Dew contamination device is described further, and in present embodiment, separation net is provided with the smoke inlet of the fumigation case 6.
The separation net is prevented from the excreta of experimental animal and falls in flue tube 3, prevents from blocking flue tube 3, and
Ensure that smog quality is not contaminated.
Specific embodiment four：Present embodiment is sudden and violent to the rodent respiratory system described in specific embodiment one
Dew contamination device is described further, and in present embodiment, it also includes：Dissipate cigarette plate 14；
Dissipate and m smoke-dispelling hole is provided with cigarette plate 14, wherein m is positive integer；
Dissipate cigarette plate 14 and be fixed on the interior lower end of fumigation case 6.
Scattered cigarette plate 14 is increased in present embodiment, in practical application, to dissipate can hold bedding and padding on cigarette plate 14, is conducive to clear
The excreta of clean experimental animal.The m smoke-dispelling hole dissipated on cigarette plate 14 ensure that smog well into fumigation case.Meanwhile, m dissipates
Cigarette hole is convex type hole, is highly 3cm, and the bedding and padding for being so prevented from being held on scattered cigarette plate 14 spill from smoke-dispelling hole.
Specific embodiment five：Present embodiment is to the rodent described in specific embodiment one, two, three or four
Respiratory system exposure contamination device is described further, and in present embodiment, it also includes：Rotating disk 4, protection network 5 and motor 8；
Rotating disk 4 is hollow structure, and surface is provided with aperture, and the outlet flue of flue tube 3 is connected with the axle center of rotating disk 4,
And to rotate connection between flue tube 3 and rotating disk 4, motor 8 is rotated for driving rotating disk 4,
Protection network 5 is fixed on the top of rotating disk 4.
In contamination device described in present embodiment, rotating disk 4, protection network 5 and motor 8 are increased, driven using motor 8
Rotating disk 4 slowly runs, and in present embodiment, rotating disk is designed as into hollow structure, be joined directly together with the outlet flue of flue tube 3 it is logical,
With the rotation of rotating disk, smog is disseminated in fumigation case 6 from the aperture of rotating disk, the smog in fumigation case 6 is uniformly spread.
Protection network 5 is located at the top of rotating disk 4, for supporting small experimental animal, while small experimental animal is isolated with rotating disk 4, prevents rotating disk 4
Rotate and accidentally injure small experimental animal, be also prevented from small experimental animal destruction rotating disk 4.Meanwhile, the outer surface of rotating disk 4 is provided with spiral lamination, can
Ensure that smog fully spreads.
Specific embodiment six：Present embodiment is to breathe system to the laboratory rodent described in specific embodiment five
System exposure contamination device is described further, and in present embodiment, the rotating speed of rotating disk 4 is 20rad/min to 30rad/min.
Specific embodiment seven：Present embodiment is to breathe system to the laboratory rodent described in specific embodiment five
System exposure contamination device is described further, and in present embodiment, the top of fumigation case 6 or the top of side wall are provided with air draft
Mouthful.
In practical application, being provided with protection network at exhaust outlet, prevent small experimental animal from climbing out of, or prevent experimental animal from climbing
To ventilating fan, small experimental animal is caused to sustain damage.
Specific embodiment eight：Present embodiment is sudden and violent to the rodent respiratory system described in specific embodiment seven
Dew contamination device is described further, and in present embodiment, it also includes：Ventilating fan 7, ventilating fan 7 is fixed on the top of fumigation case 6
At exhaust outlet, motor 8 is used to drive ventilating fan 7 to rotate.
Ventilating fan 7 is increased in present embodiment, ventilating fan 7 can make the inside of fumigation case 6 keep ventilation with outside, so that
Ensure that smokescope is uniform in fumigation case 6, it is ensured that oxygen content in fumigation case 6.
Specific embodiment nine：Present embodiment is sudden and violent to the rodent respiratory system described in specific embodiment eight
Dew contamination device is described further, and in present embodiment, ventilating fan 7 is fanned for bi-directional discharging.
Specific embodiment ten：Reference picture 3 and Fig. 4 illustrate present embodiment, the rodent described in present embodiment
Animal breath system exposes contamination device, and it includes：Flue tube 3,6, two, fumigation case unidirectional baffle plate 9, three-port structure 10, piston
11 and cigarette holder 13；
The smoke inlet of fumigation case 6 is connected with the outlet flue of flue tube 3；
The port of piston 11 connects with a port of three-port structure 10, second port and the cigarette holder 13 of the three-port structure
Outlet flue be connected, the 3rd port of the three-port structure is connected with the smoke inlet of flue tube 3；
A unidirectional baffle plate is provided between the outlet flue of the three-port structure 10 and cigarette holder 13, the unidirectional baffle plate is only capable of
Opened towards the side of three-port structure 10,
A unidirectional baffle plate is provided between the smoke inlet of the three-port structure 10 and flue tube 3, the unidirectional baffle plate is only
Can be opened to the side of flue tube 3,
Piston 11 can move reciprocatingly in a port of three-port structure 10.
Be inserted in the smoke absorbing end of cigarette on cigarette holder 13 when actually used by present embodiment, can manually pull piston 11
It is reciprocating, it is also possible to be slided in smoke collection case 2 with piston 11 using the drive transmission device 12 of motor 8, work as transmission
When mechanism 12 pulls piston 11, a unidirectional slide 9 is opened, and No. two unidirectional slides 10 are closed, and cigarette holder 13 is by smog inspiration, smog
It is drawn into smoke collection case 2；When transmission mechanism 12 promotes piston 11, a unidirectional slide 9 is closed, No. two unidirectional slides 10
Open, the smog in smoke collection case 2 is pushed into flue tube 3, hence into fumigation case 6.Employed in present embodiment
Motor 8 controls piston speed by the form that large and small gear is combined, and makes the speed uniform, controllable of suction or vapour discharge, protects
Confirmation smokescope constant needed for testing.The rotary motion that motor is exported can be converted into linear motion by transmission mechanism 12, from
And drive piston movement.
Specific embodiment 11：Reference picture 3 and Fig. 4 illustrate present embodiment, the grinding tooth described in present embodiment
Class animal breath system exposes contamination device, and it includes：Flue tube 3, fumigation case 6, two check valves, three-port structures 10, piston
11 and cigarette holder 13；
The smoke inlet of fumigation case 6 is connected with the outlet flue of flue tube 3；
The port of piston 11 connects with a port of three-port structure 10, second port and the cigarette holder 13 of the three-port structure
Outlet flue be connected, the 3rd port of the three-port structure is connected with the smoke inlet of flue tube 3；
A check valve is provided between the outlet flue of the three-port structure 10 and cigarette holder 13, the check valve is only capable of direction
The side of three-port structure 10 is opened,
Be provided with a check valve between the smoke inlet of the three-port structure 10 and flue tube 3, the check valve be only capable of to
The side of flue tube 3 is opened,
Piston 11 can move reciprocatingly in a port of three-port structure 10；
The smoke absorbing end of cigarette is inserted on cigarette holder 13.
Rodent respiratory system exposure contamination device described in specific embodiment ten and 11, by motor and
Piston simulates human body respiration process, obtains the cigarette environment in people's suction body, solves existing contamination device and is merely able to simulation two
Hand cigarette environment, so as to cause existing exposure experiment to obtain the big problem of resultant error.
Specific embodiment 12：Present embodiment is that the rodent described in specific embodiment ten or 11 is exhaled
Desorption system exposure contamination device is described further, and in present embodiment, cigarette holder 13 is bull cigarette holder.
The bull cigarette holder can be while many cigarettes of grafting, reach while gathering the effect of a large amount of smog, it is adaptable to same
When multiple acceptors are contaminated, prevent difference.
Specific embodiment 13：Present embodiment is to breathe system to the rodent described in specific embodiment 12
System exposure contamination device is described further, and in present embodiment, it also includes：Plug, the plug is used for idle cigarette holder
Mouth sealing.
Plug can fill the hole that bull cigarette holder takes less than in experimentation, it is ensured that the seal of device, also ensure
Suck the concentration of smog.
Specific embodiment 14：Present embodiment is that the rodent described in specific embodiment ten or 11 is exhaled
Desorption system exposure contamination device is described further, and in present embodiment, it also includes：Disposable box, the disposable box is located at cigarette holder
13 lower sections.
Disposable box is used to collect the cigarette end and cigarette ash after burning, prevents cigarette ash to be scattered everywhere, and indoor environment is damaged.
Specific embodiment 15：Present embodiment is that the rodent described in specific embodiment one, ten or 11 is moved
Thing respiratory system exposure contamination device is described further, and in present embodiment, the material of fumigation case 6 is lucite.
The material of the smoke collection case 2 described in specific embodiment one is also lucite.
Specific embodiment 16：Present embodiment is that the rodent described in specific embodiment one, ten or 11 is moved
Thing respiratory system exposure contamination device is described further, in present embodiment, the smoke collection case 2, flue tube 3 and fumigation
It is to be detachably connected between case 6.
Specific embodiment 17：Present embodiment is that the rodent described in specific embodiment ten or 11 is exhaled
Desorption system exposure contamination device is described further, in present embodiment, the cigarette holder 13, three-port structure 10, flue tube 3 and smoked
It is between smoke box 6 and is detachably connected.
Contamination device described in specific embodiment 16 and 17 is easy to cleaning to be detachably connected, and ensure that case
Interior environment.
Claims (10)
1. rodent respiratory system exposes contamination device, it is characterised in that it includes：Smoke collection case (2), flue tube
(3), rotating disk (4), fumigation case (6), motor (8) and scattered cigarette plate (14)；
The outlet flue of smoke collection case (2) is connected by flue tube (3) with the smoke inlet of fumigation case (6)；
The flue tube (3) is provided with n turning, and n is the positive integer more than or equal to 3；
Dissipate and m smoke-dispelling hole is provided with cigarette plate (14), wherein m is positive integer；Dissipate cigarette plate (14) and be fixed on fumigation case (6) interior subordinate
End；
Rotating disk (4) is hollow structure, and surface is provided with aperture, and the outlet flue of flue tube (3) is connected with the axle center of rotating disk (4)
It is logical, and for rotation is connected between flue tube (3) and rotating disk (4), motor (8) is rotated for driving rotating disk (4).
2. rodent respiratory system according to claim 1 exposes contamination device, it is characterised in that the fumigation case
(6) separation net is provided with smoke inlet.
3. rodent respiratory system according to claim 1 exposes contamination device, it is characterised in that rotating disk (4)
Rotating speed is 20rad/min to 30rad/min.
4. rodent respiratory system according to claim 1 exposes contamination device, it is characterised in that fumigation case (6)
Top or the top of side wall be provided with exhaust outlet.
5. rodent respiratory system according to claim 4 exposes contamination device, it is characterised in that it also includes：
Ventilating fan (7), ventilating fan (7) is fixed at the exhaust outlet of fumigation case (6) top, and motor (8) is rotated for driving ventilating fan (7).
6. rodent respiratory system exposes contamination device, it is characterised in that it includes：Flue tube (3), rotating disk (4), fumigation
Case (6), motor (8), two unidirectional baffle plates (9), three-port structure (10), piston (11) and cigarette holders (13)；
The smoke inlet of fumigation case (6) is connected with the outlet flue of flue tube (3)；
The port of piston (11) connects with a port of three-port structure (10), the second port and cigarette holder of the three-port structure
(13) outlet flue is connected, and the 3rd port of the three-port structure is connected with the smoke inlet of flue tube (3)；
A unidirectional baffle plate is provided between the outlet flue of the three-port structure (10) and cigarette holder (13), the unidirectional baffle plate is only capable of
Opened towards three-port structure (10) side,
A unidirectional baffle plate is provided between the smoke inlet of the three-port structure (10) and flue tube (3), the unidirectional baffle plate is only
Can be opened to flue tube (3) side,
Rotating disk (4) is hollow structure, and surface is provided with aperture, and the outlet flue of flue tube (3) is connected with the axle center of rotating disk (4)
It is logical, and for rotation is connected between flue tube (3) and rotating disk (4), motor (8) is rotated for driving rotating disk (4)；
Piston (11) can move reciprocatingly in a port of three-port structure (10)；
The smoke absorbing end of cigarette is inserted on cigarette holder (13).
7. rodent respiratory system exposes contamination device, it is characterised in that it includes：Flue tube (3), rotating disk (4), fumigation
Case (6), two check valves, motor (8), three-port structure (10), piston (11) and cigarette holders (13)；
The smoke inlet of fumigation case (6) is connected with the outlet flue of flue tube (3)；
The port of piston (11) connects with a port of three-port structure (10), the second port and cigarette holder of the three-port structure
(13) outlet flue is connected, and the 3rd port of the three-port structure is connected with the smoke inlet of flue tube (3)；
A check valve is provided between the outlet flue of the three-port structure (10) and cigarette holder (13), the check valve is only capable of direction
Three-port structure (10) side is opened,
Be provided with a check valve between the smoke inlet of the three-port structure (10) and flue tube (3), the check valve be only capable of to
Flue tube (3) side is opened,
Rotating disk (4) is hollow structure, and surface is provided with aperture, and the outlet flue of flue tube (3) is connected with the axle center of rotating disk (4)
It is logical, and for rotation is connected between flue tube (3) and rotating disk (4), motor (8) is rotated for driving rotating disk (4)；
Piston (11) can move reciprocatingly in a port of three-port structure (10)；
The smoke absorbing end of cigarette is inserted on cigarette holder (13).
8. the rodent respiratory system according to claim 6 or 7 exposes contamination device, it is characterised in that cigarette holder
(13) it is bull cigarette holder.
9. the rodent respiratory system according to claim 1,6 or 7 exposes contamination device, it is characterised in that fumigation
The material of case (6) is lucite.
10. the rodent respiratory system according to claim 6 or 7 exposes contamination device, it is characterised in that the cigarette
It is between mouth (13), three-port structure (10), flue tube (3) and fumigation case (6) and is detachably connected.
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| CN201410631909.7A CN104306081B (en) | 2014-11-11 | 2014-11-11 | Rodent respiratory system exposes contamination device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410631909.7A CN104306081B (en) | 2014-11-11 | 2014-11-11 | Rodent respiratory system exposes contamination device |
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| CN104306081B true CN104306081B (en) | 2017-06-20 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104605960B (en) * | 2015-02-26 | 2016-08-17 | 郑州大学第一附属医院 | A kind of experimental provision studying cardiopulmonary vascular event mechanism |
| CN104856781B (en) * | 2015-06-17 | 2017-06-27 | 徐向前 | Experimental animal sootiness modeling case and its modeling method |
| CN105455917A (en) * | 2015-12-22 | 2016-04-06 | 泰山医学院 | Device for rat body composition auxiliary measurement, and application method thereof |
| CN106725992B (en) * | 2016-12-27 | 2018-05-18 | 山西医科大学 | A kind of passive smoking device for being used to prepare Chronic Obstructive Pulmonary Disease animal model |
| CN112891014B (en) * | 2021-01-18 | 2022-05-06 | 辽宁中医药大学 | Suction-type anaesthesia device for experimental animals |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100455274C (en) * | 2007-08-16 | 2009-01-28 | 首都医科大学附属北京朝阳医院 | Normal pressure low oxygen toxicity contaminated system |
| CN201701329U (en) * | 2010-06-04 | 2011-01-12 | 浙江大学 | Smoke exposing device for building mold of chronic obstructive pulmonary disease |
| CN202110166U (en) * | 2011-05-26 | 2012-01-11 | 山西大学 | Dynamic toxicant exposure device for toxic gas |
| CN202950790U (en) * | 2012-11-13 | 2013-05-29 | 天津开发区合普工贸有限公司 | Animal experiment device of producing of passive smoking through smoking with human mouths |
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