CN218212873U

CN218212873U - Smoking device for simulating animal smoke exposure

Info

Publication number: CN218212873U
Application number: CN202222238314.8U
Authority: CN
Inventors: 王凤山; 任晨艳; 陈上
Original assignee: Shandong University
Current assignee: Shandong University
Priority date: 2022-08-24
Filing date: 2022-08-24
Publication date: 2023-01-03
Anticipated expiration: 2032-08-24

Abstract

The utility model particularly relates to a smoking device that simulation animal smog exposes, bear the cage including vacuum pump, box, oxygenation pump, cigarette seat, toy. The box combustion chamber bottom is arranged in to the cigarette seat, and the box exposes the room bottom in to the toy bears the cage, and the box is in the centre, and oxygenation pump and vacuum pump are connected respectively to both sides. Compared with the prior art, the manufactured device for modeling the experimental animal model of the chronic obstructive pulmonary disease has the advantages of uniform smoke, simple operation, high model success rate, high animal survival rate, easy manufacture and the like. In the aspect of device structure, the device low cost, the convenient observation of operation process can collect environment smog solution simultaneously and carry out the model aassessment, and convenient clearance increases the experimental scientificity and the success rate of moulding. The fume hood can be placed in a fume hood to reduce the fume leakage to the maximum extent from the consideration of experimental safety, has low environmental pollution and is beneficial to protecting the safety of experimenters.

Description

Smoking device for simulating animal smoke exposure

Technical Field

The utility model belongs to the technical field of animal test equipment, concretely relates to smoking device that simulation animal smog exposes.

Background

The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art that is already known to a person of ordinary skill in the art.

Chronic obstructive pulmonary disease, also known as chronic obstructive pulmonary disease, is a common respiratory disease caused by airflow obstruction and is an important public health challenge. The pathological process of the chronic obstructive lung occurs based on the innate and adaptive inflammatory immune mechanisms of the lung caused by exposure, inhaled toxic gases and particulate matter. Cigarette smoke is the major environmental cause of such inhalation damage. Cigarette smoke can be divided into mainstream smoke, which acts primarily on the smoker itself, and sidestream smoke, which transmits this harmful effect to the population surrounding the smoker.

The representative animal model of the chronic obstructive pulmonary disease has great value for researching the pathogenesis, the treatment target and the drug evaluation of the chronic obstructive pulmonary disease. Cigarette smoke is used as an important risk factor for the development of chronic obstructive pulmonary disease, and reasonable cigarette smoke exposure in an animal model is an important factor for simulating the disease state of chronic obstructive pulmonary disease. Aiming at the design of the existing slow obstructive pulmonary disease model, the model is roughly divided into two types, namely professional smoke exposure equipment and a self-made equipment box according to the experimental requirements. The professional flue gas exposure equipment is high in price, large in occupied area and low in universality, and is not suitable for small-scale experiments in laboratories. The self-made equipment box is low in cost, but poor in smoke distribution, difficult to monitor environmental smoke exposure conditions, prone to death of mice and the like. Therefore, the simple and reliable mouse chronic obstructive pulmonary disease model device plays an important role in development of chronic obstructive pulmonary disease medicines.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a smoking of measurable stream cigarette exposes device for preparation mouse or rat hinders lung disease model slowly, overcomes among the prior art shortcoming such as the equipment cost is high, smog distribution is inhomogeneous, the animal death rate is high simultaneously, constructs a stable, easily assemble, and with low costs lab scale experimental apparatus.

Based on the above purpose, the utility model provides a following technical scheme:

a smoking device for simulating the exposure of animal smoke comprises a box body, an oxygenation pump and a vacuum pump; the box body is divided into a combustion chamber and an exposure chamber by a smoke kneading plate, a cigarette seat is arranged in the combustion chamber and used for bearing cigarettes, and a small animal bearing cage is arranged in the exposure chamber;

the oxygenation pump is arranged on the side of the combustion chamber and is communicated with the combustion chamber;

the vacuum pump is arranged on the exposure chamber side and is communicated with the exposure chamber.

Preferably, the top of the box body is provided with a detachable cover, and the center of the cover is provided with a balancing hole.

Preferably, the small animal bearing cage is formed by splicing grating plates, and the inside of the small animal bearing cage is divided into a plurality of spaces with the same size by the grating plates.

Furthermore, the top of the small animal bearing cage is provided with a clamping groove, and a grid plate at the top of the small animal bearing cage is drawn out and pushed in through the clamping groove; furthermore, one side of the top grid plate is provided with a clamping ring for placing a T-shaped lock catch, and after the small animal is placed in the small animal bearing cage, experimenters can lock the small animal bearing cage through the T-shaped lock.

Preferably, the outer side surface of the exposure chamber is provided with an air exhaust hole, and the air exhaust hole is connected with a vacuum pump through a pipeline; further, still set up utensil stopper receiving flask between vacuum pump and the exposure room, hold the solution that is used for collecting smog in the receiving flask, have the through-hole on the bottle stopper of receiving flask and be used for fixed pipeline, respectively through pipeline and exposure room and vacuum pump intercommunication, the pipeline of bottle stopper end does not stretch into below the liquid level.

Preferably, a detachable movable plate is arranged on the outer side surface of the combustion chamber, and an air inlet hole is formed in the center of the movable plate and communicated with the oxygenation pump through the air inlet hole.

Preferably, the holder is integrally formed, comprises a cigarette retaining portion, and has a pocket below the path of combustion of the cigarette for receiving the ash.

Preferably, the smoke kneading plate is fully distributed with through holes, and the total transmission area of the through holes accounts for 70% or more of the total area of the smoke kneading plate.

Preferably, the exposure chamber is provided with a PM 2.5 detector for monitoring environmental particulate matters in the smoke exposure process.

The beneficial effects of one or more technical schemes are as follows:

the utility model discloses a construct a stable, easily duplicate, with low costs and smog distribution even lab scale experimental apparatus. Preferably, the box body is divided into a combustion chamber and an exposure chamber, the combustion chamber is internally provided with a cigarette seat, the number of cigarettes can be adjusted according to the experiment requirement, and the space proportion of the combustion chamber and the exposure chamber can be adjusted by adjusting the position of the rubbing plate so as to meet the experiment requirements under different conditions.

The utility model discloses compare prior art's an improvement point lies in, the combustion chamber with expose the room and rub the board with smog and separate, this kind of mode of setting can make cigarette smog accomplish burning, intensive in advance in the combustion chamber to the dispersion is even. A plurality of through-holes that distribute on the board is kneaded to smog also can realize a "mixing" effect to smog, and the smog with this kind of mixing gets into the exposure room through the suction effect of vacuum pump, makes the laboratory animal can expose in the smog environment that a concentration is more even, is favorable to guaranteeing the stability of experimental variable.

The utility model discloses an improvement point of comparing prior art still lies in, the toy bears the cage and can correspond each group according to the experiment demand and increase or reduce the quantity that bears the cage to bear the inside space that is divided into the homogeneous by the grid of cage, lead to the animal to expose the smoking degree inequality because of reasons such as fear gather in the experimental animal. In addition, the bearing cage and the exposure chamber are designed in a split mode, a urine pad can be placed below the bearing cage, small animal excrement can be conveniently cleaned, and cleanliness and scientificity of the experimental device are greatly improved.

The utility model discloses an improvement point that compares prior art still lies in, except can be convenient the cigarette of lighting of setting up of fly leaf, its design adopts the pressfitting mode, can also be alleviated and adjust the box expend with heat and contract with cold that causes because of long-term the use through the upset regulation fly leaf, and the outside is equipped with the bolt and can increases the seal.

The utility model discloses compare prior art's an improvement point still lies in, vacuum pump and still have the utensil stopper receiving flask between the room that exposes, can be used to collect smog solution, expose the process to smog and monitor.

Drawings

The accompanying drawings, which form a part of the specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention and not to constitute a limitation on the invention.

Fig. 1 is a schematic structural view of a smoking device for simulating the exposure of animal smoke according to the present invention;

wherein, 1-a vacuum pump, 2-an air suction hole, 3-a cover, 4-a balance hole, 5-a smoke combustion chamber, 6-a smoke kneading board, 7-a small animal carrying cage, 8-a smoke exposure chamber, 9-a box body, 10-a movable board, 11-an air inlet, 12-an oxygenation pump, 13-a smoke seat and 14-a collection bottle;

fig. 2 is a three-view and overall structure schematic diagram of the small animal carrying cage.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments in accordance with the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

In order to make the technical solutions of the present invention more clearly understood by those skilled in the art, the technical solutions of the present invention will be described in detail below with reference to specific embodiments.

Example 1

In the embodiment, a smoking device for simulating the exposure of animal smoke is provided, as shown in fig. 1, the smoking device is composed of a box body 9, an oxygenation pump 1 and a vacuum pump 12; the box body 9 is divided into a combustion chamber 5 and an exposure chamber 8 by a smoke kneading plate 6, a cigarette seat 13 is arranged in the combustion chamber 5 and used for bearing cigarettes, and a small animal bearing cage 7 is arranged in the exposure chamber 8.

Wherein, the box 9 adopts colorless acrylic material, and thickness is 4mm, can audio-visual from the outside see the smog dispersion condition and the animal activity condition in the box 9. The top of the box body 9 is provided with a detachable cover 3, the center of the cover 3 is provided with a balance hole 4 with the aperture of 20mm, and the balance hole 4 is a through hole and is used for balancing the pressure in the exposure chamber 8. During the smoke exposure, the upper hole may be covered with gauze in order to ensure the pressure in the exposure chamber 8 and to reduce smoke loss.

Expose 8 inside little animals of placing of room and bear cage 7, the whole body of little animals bears cage 7 forms for the grid concatenation of ya keli material, and the size slightly is lighter than exposes room 8, and inside is cut apart into the space of a plurality of the same sizes by the grid, and 1-2 animals can be held in every space to avoid piling up because of the animal and crouching in the uneven condition of smog suction that leads to in the box corner. In addition, the top of the small animal carrying cage 7 is provided with a clamping groove, the grid plate at the top of the small animal carrying cage is drawn out and pushed in through the clamping groove, and the top grid is provided with a T-shaped lock catch (an arrow in figure 2) through a side clamping ring for controlling the small animal carrying cage to be closed. The thickness of the plate of the grid plate of the small animal bearing cage is 3mm, the width of each grid strip in the grid plate is 4mm, gaps of 9mm are formed between the grid strips, and the size can guarantee the strength of the small animal bearing cage and guarantee the smoke exposure effect. In addition, the width of the top of the grating plate is 7mm, and the distance is reserved for slotting. Before use, the bottom of the small animal carrying cage 7 may be pre-padded and the animal may be placed to keep the exposure chamber 8 clean. An air suction hole 2 is arranged on the outer side panel of the exposure chamber 8, the rubber tube is connected through the air suction hole 2, the vacuum pump 1 containing a collecting bottle 14 is connected through the rubber tube and the rubber plug, and the collecting bottle 14 is used for containing solution capable of absorbing smoke.

The outer side surface of the combustion chamber 5 is provided with a detachable movable plate 10, the center of the movable plate 10 is provided with an air inlet 11 with the aperture of 20mm, and the air inlet 11 is provided with a cut rubber plug and a rubber tube which are connected with an oxygenation pump 12. The movable plate 10 can be fixed to the main body of the box 9 by a bolt, and when the cigarette in the combustion chamber 5 needs to be ignited, the movable plate 10 is detached for operation. The combustion chamber 5 has a cigarette holder 13 therein, and the cigarette holder 13 is integrally formed, includes a cigarette holding portion, and has a case for receiving cigarette ash below a combustion path of the cigarette. And through holes with the aperture of 2mm are distributed on the smoke kneading plate 6.

The smoking device is used as follows: and locking the T-shaped lock catch in the animal small animal bearing cage 7 to be smoked, putting the animal small animal bearing cage into a smoke exposure chamber with a laid urine pad, connecting the whole experimental device, opening the vacuum pump 1 and the oxygenation pump 12, and adjusting the knob to enable the air flow of the vacuum pump 1 and the oxygenation pump 12 to be equal. Then the movable plate 10 is opened to fix the cigarette through the cigarette seat 13 and ignite. During the combustion of the cigarette, an enrichment of the smoke in the smoke combustion chamber can be observed. The fumes exiting the device are collected by a collection bottle 14. The experimenter can evaluate smoking by testing the liquid in the collection bottle 14.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A smoking device for simulating the exposure of animal smoke is characterized in that the smoking device consists of a box body, an oxygenation pump and a vacuum pump; the box body is divided into a combustion chamber and an exposure chamber by a smoke kneading plate, a cigarette seat is arranged in the combustion chamber and used for bearing cigarettes, and a small animal bearing cage is arranged in the exposure chamber;

2. A smoking device for simulating animal smoke exposure according to claim 1, wherein the housing has a removable lid on the top with a balancing hole in the centre of the lid.

3. A smoking device for simulating animal smoke exposure according to claim 1, wherein said small animal carrying cage is a split grid having interior portions divided into a plurality of spaces of equal size by said grid.

4. A smoking device according to claim 3, wherein the top of the small animal carrying cage has a slot through which a top grid plate of the small animal carrying cage is drawn and pushed; one side of top grid plate has the snap ring for place T type hasp, after the toy was put into, experimenter accessible T type lock carried the cage to the toy and locks.

5. The smoking device for simulating animal smoke exposure of claim 1, wherein the outer side of the exposure chamber is provided with an air suction hole, and the air suction hole is connected with a vacuum pump through a pipeline.

6. A smoking device for simulating animal smoke exposure according to claim 5, wherein a collection bottle with a plug is further arranged between the vacuum pump and the exposure chamber, the collection bottle contains a solution for collecting smoke, a through hole is formed in the plug of the collection bottle and used for fixing a pipeline which is respectively communicated with the exposure chamber and the vacuum pump through the pipeline, and the pipeline at the end of the plug does not extend below the liquid level.

7. A smoking device for simulating smoke exposure in an animal as claimed in claim 1, wherein a removable movable plate is provided on the outer side of the combustion chamber, and an air inlet is provided in the center of the movable plate and communicates with the oxygenation pump through the air inlet.

8. A smoking device for simulating animal smoke exposure according to claim 1, wherein the holder is integrally formed, includes a cigarette holder, and has a box below the combustion path of the cigarette for receiving the ash.

9. A smoking device for simulating animal smoke exposure according to claim 1, wherein the smoke flap is provided with perforations, the total area of the perforations being 70% or more of the total area of the smoke flap.

10. A smoking device for simulating smoke exposure in an animal according to claim 1, wherein the exposure chamber is provided with a PM 2.5 detector for monitoring environmental particulates during the smoke exposure.