CN105455220B - A kind of device of laboratory animal simulation people actively smoking effect - Google Patents
A kind of device of laboratory animal simulation people actively smoking effect Download PDFInfo
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- CN105455220B CN105455220B CN201610010429.8A CN201610010429A CN105455220B CN 105455220 B CN105455220 B CN 105455220B CN 201610010429 A CN201610010429 A CN 201610010429A CN 105455220 B CN105455220 B CN 105455220B
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- laboratory animal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses the device of a kind of laboratory animal simulation people actively smoking effect, including smoke from cigarette generator, also include animal per os Smoking pipe and for limiting the holder of laboratory animal activity, one end of described animal per os Smoking pipe is connected with smoke from cigarette generator, and the other end stretches in holder in the oral cavity of laboratory animal；Described holder includes housing, baffle plate, slide block and is provided with the base plate of chute, and described housing is fixedly connected on base plate, and slide block slides in the chute being located at base plate, and panel hinge is on slide block, and closes the inner chamber of housing.The present invention is convenient to operate, convenient fixing, simple in construction.
Description
Technical field:
The present invention relates to the device of a kind of laboratory animal simulation people actively smoking effect.
Background technology:
Animal smoking model is the important carrier of smoking relevant disease research, plays extremely critical effect in terms of the pathogenesis and treatment of Induced By Tobacco Smoke disease in research.
The existing animal smoking model overwhelming majority is laboratory animal to be placed in the container of a full smoke from cigarette, laboratory animal body surface is completely disposed under smoky environment, smoke from cigarette via intranasal application is sucked in lung by autonomous respiration mode by animal, it is achieved animal breath system or body surface expose smog.Smoke from cigarette can not be directly delivered in the oral cavity of laboratory animal by this kind of mode, but breathed by laboratory animal via intranasal application and simulate people's passive smoking process, so the experimental data drawn can not simulate the effect of people's actively smoking.Actively smoking animal model is made by experimental provision and laboratory animal smoking addiction makes animal by smoke from cigarette direct oral cavity suction body by the way of sucking, simulates people's actively smoking effect substantially.
Additionally, when laboratory animal simulation people actively smoking experiment, need laboratory animal to be fixed in a holder, existing fixer structure is complicated, generally requires multiple experimenter and works in coordination, could be fixed by animal.
Therefore, necessary prior art improves to solve the deficiency of prior art.
Summary of the invention:
The present invention is in order to solve the problem of above-mentioned prior art existence and to provide the device of a kind of laboratory animal simulation people actively smoking effect.
The technical solution adopted in the present invention has: the device of a kind of laboratory animal simulation people actively smoking effect, including smoke from cigarette generator, also include animal per os Smoking pipe and for limiting the holder of laboratory animal activity, one end of described animal per os Smoking pipe is connected with smoke from cigarette generator, and the other end stretches in holder in the oral cavity of laboratory animal；
Described holder includes housing, baffle plate, slide block and base plate, described housing is fixedly connected on base plate, baffle plate is positioned on rear side of housing and is articulated with on slide block, move with slide block, and opened or the inner chamber of closure shell by the motion of relative housing, form the containing cavity suitable with placed experimental animals length.
Further, described housing locating slot and the gathering sill of being respectively provided on two sides with symmetrical above and below, described baffle plate is provided with guide finger suitable with gathering sill and locating slot respectively and positioning bar, guide finger and positioning bar are slidably arranged in gathering sill and locating slot respectively.
Further, corresponding to being respectively equipped with, at the both sides cell wall of locating slot, the location side plate being parallel to each other on the upside of described housing, and it is respectively equipped with waist-shaped hole on this two location side plate, waist-shaped hole on two location side plates is mutually communicated, and described positioning bar is provided with and positions the hole, location that the height and position of waist-shaped hole on side plate is suitable.
Further, described upper end of slide block is provided with two boss, and the guide finger of described baffle plate is articulated with between two boss.
Further, described base plate is provided with chute, and slide block slides and is located in this chute, and baffle plate slides with slide block and moves at housing cavity, and moves, by this, the containing cavity that formation is suitable with experimental animals length.
Further, housing forward end taper is shunk, and forms the bucket shape chamber accommodating laboratory animal head, and front end, bucket shape chamber is provided with the first through hole, and baffle plate is provided with the second through hole for placing laboratory animal afterbody.
Further, described animal per os Smoking pipe includes supervisor, arm and spring, and arm described in two is connected with an opening of supervisor, and spring is connected between two arms.
Further, described arm being bonded with connection boss, the sidewall of this connection boss is provided with the connecting hole for connecting spring, and the side end face connecting boss is provided with arc groove suitable with arm outer wall.
Further, all inwardly bending of the two ends of described spring also forms bending part, and the two ends of spring are sheathed on two connection boss, and the bending part of spring is connected in the connecting hole connecting boss.
Further, described arm is the cylinder that one end open one end is closed, and the opening of arm is connected with the opening of supervisor, is provided with some fumaroles on the sidewall of arm and along a tube axis direction.
Laboratory animal is placed in holder, one end of animal per os Smoking pipe is connected with smoke from cigarette generator, the other end stretches in holder in the oral cavity of laboratory animal, it is provided with spring between two arms of animal per os Smoking pipe one end, after arm is placed in laboratory animal oral cavity, unclamp arm, two arms are under spring force, two arms discharge in laboratory animal oral cavity and are supported in laboratory animal oral cavity, and animal per os Smoking pipe will not depart from the oral cavity of laboratory animal due to the struggle of laboratory animal；Due to animal in a reservoir have proal front taxis, after in the holder that animal is placed in the present invention, only need to be by barrier slides to holder, then animal can be confined in holder by cross-under bolt, consequent provide the benefit that: the present invention is convenient to operate, good fixing effect, have only to an experimenter can be fixed by animal, directly animal per os Smoking pipe arm is placed in laboratory animal oral cavity, the experimental data drawn is accurate, can maximize the effect of simulation people actively smoking.
Accompanying drawing illustrates:
Fig. 1 is the structure chart of apparatus of the present invention.
Fig. 2 is holder right TV structure figure in the present invention.
Fig. 3 is the top view (wherein base plate is positioned at the end of housing) of holder in the present invention.
Fig. 4 is the baffle plate Unclosing structure figure of holder in the present invention.
Fig. 5 is the structure chart that in the present invention, base plate is positioned in housing cavity.
Fig. 6 is animal per os Smoking pipe structure chart in the present invention.
Fig. 7 is connection boss sectional view on arm in Fig. 6.
Fig. 8 is the partial enlarged drawing of thing per os Smoking pipe in Fig. 6.
Detailed description of the invention:
The present invention is further illustrated below in conjunction with the accompanying drawings.
As shown in Figure 1, the device of a kind of laboratory animal of present invention simulation people actively smoking effect, including animal per os Smoking pipe 2, smoke from cigarette generator 3 and for limiting the holder 1 of laboratory animal activity, one end of animal per os Smoking pipe 2 is connected with smoke from cigarette generator 3, and the other end stretches in holder 1 in the oral cavity of laboratory animal.
In conjunction with Fig. 2 and Fig. 3, including baffle plate 12, base plate 13, slide block 15 and the housing 11 being provided with inner chamber, housing 11 is fixedly connected on base plate 13 by gripper shoe 4, baffle plate 12 is positioned at the rear side of housing 11 and is articulated with on slide block 15, move with slide block 15, and opened or the inner chamber of closure shell 11 by the motion of relative housing 11, form the containing cavity suitable with placed experimental animals length.
Symmetrical above and below at housing 11 is respectively provided on two sides with gathering sill 110 and locating slot 111, baffle plate 12 is provided with guide finger 120 suitable with gathering sill 110 and locating slot 111 respectively and positioning bar 121, guide finger 120 and positioning bar 121 are slidably arranged in gathering sill 110 and locating slot 111 respectively.
On housing 11 and be positioned at the both sides of locating slot 111 and be provided with location side plate 112, being respectively equipped with waist-shaped hole 113 on this two location side plate 112, the waist-shaped holes 113 on two location side plates 112 are mutually communicated.
Positioning bar 121 is provided with and positions the hole, location 123 that the height and position of waist-shaped hole on side plate 112 is suitable.
The present invention, for ease of baffle plate 12 slip on base 13, is provided with chute 14 on base 13, and slide block 15 is slidably connected in this chute 14, is provided with two boss 151 in slide block 15 upper end, the guide finger 120 of baffle plate 12 by hinge between these two boss 151.
Such as Fig. 4 and Fig. 5, open baffle plate 12, the inner chamber making housing 11 is opened, as laboratory animal is put under this kind of state, forerunner's property of laboratory animal makes it enter in housing 11 along baffle plate 12, rotate and moving stop 12, the inner chamber of baffle plate 12 closure shell 11, baffle plate 12 is promoted to make its gathering sill 110 along housing 11 and locating slot 111 slide, be adjusted to the suitable position of body body length of laboratory animal after, fasten with nut after bolt cross-under waist-shaped hole 113 and hole 123, location, make baffle plate 12 fix, so that laboratory animal is fixed on the interior intracavity of housing 11.
Housing 11 in the present invention is the column construction of both ends open, the front end taper of housing 11 is shunk, forming the bucket shape chamber 114 accommodating laboratory animal head, front end, bucket shape chamber 114 is provided with the first through hole, is provided with the second through hole 124 for placing laboratory animal afterbody on baffle plate 12.
Such as Fig. 6 and Fig. 7, animal per os Smoking pipe 2 in the present invention includes being responsible for 20 and arm 21, two arms 21 are connected with an opening of supervisor 20, two arms 21 are equipped with the connection boss 24 of cylinder, the sidewall of this connection boss 24 is provided with connecting hole 242, being provided with arc groove 241 on the side end face connecting boss 24, this arc groove 241 is suitable with the outer wall of arm 21.When connection boss 24 is adhered on arm 21, the corresponding position spreading glue on arm 21 sidewall, and also spreading glue in the arc groove 241 connecting boss 24, thus connection boss 24 is bonded on arm 21.
Such as Fig. 8, the all inwardly bending of two ends up and down of the spring 22 in the present invention is also formed with bending part 220, when spring 22 is connected between two arms 21, spring 22 two ends are sheathed on two connection boss 24, and the bending part 220 of 22 liang of ends of spring are connected in the connecting hole 242 connected on boss 24.
The cylindrical structure that arm 21 in the present invention is closed for one end open one end, the opening of arm 21 is connected with the opening with supervisor 20, the sidewall of every arm 21 is equipped with some fumaroles 23, fumarole 23 is arranged along arm 21 axis direction, and fumarole 23 is uniformly distributed in the non-outside of arm end.It is opened in the fumarole 23 on arm 21 sidewall and can fully smoke from cigarette be full of the oral cavity of animal.
When being simulated the zoopery of people's actively smoking, clutch two arm 21 holddown springs 22, after arm 21 is placed in laboratory animal oral cavity, unclamp arm 21, spring 22 recoils in situ, two arms 21 discharge in laboratory animal oral cavity and are supported in laboratory animal oral cavity, and under spring force, laboratory animal cannot shake off the animal per os Smoking pipe 2 in oral cavity.
The above is only the preferred embodiment of the present invention, it is noted that for those skilled in the art, can also make some improvement under the premise without departing from the principles of the invention, and these improvement also should be regarded as protection scope of the present invention.
Claims (10)
1. the device of a laboratory animal simulation people actively smoking effect, including smoke from cigarette generator (3), it is characterized in that: also include animal per os Smoking pipe (2) and for limiting the holder (1) of laboratory animal activity, one end of described animal per os Smoking pipe (2) is connected with smoke from cigarette generator (3), and the other end stretches in the oral cavity of holder (1) interior laboratory animal；
Described holder (1) includes housing (11), baffle plate (12), slide block (15) and base plate (13), described housing (11) is fixedly connected on base plate (13), baffle plate (12) is positioned at housing (11) rear side and is articulated with on slide block (15), mobile with slide block (15), and opened or the inner chamber of closure shell (11) by the motion of relative housing (11), form the containing cavity suitable with placed experimental animals length.
2. the device of laboratory animal simulation people actively smoking effect as claimed in claim 1, it is characterized in that: described housing (11) is symmetrical above and below is respectively provided on two sides with locating slot (111) and gathering sill (110), described baffle plate (12) is provided with guide finger (120) suitable with gathering sill (110) and locating slot (111) respectively and positioning bar (121), guide finger (120) and positioning bar (121) are slidably arranged in gathering sill (110) and locating slot (111) respectively.
3. the device of laboratory animal simulation people actively smoking effect as claimed in claim 2, it is characterized in that: described housing (11) upside is corresponding to being respectively equipped with, at the both sides cell wall of locating slot (111), the location side plate (112) being parallel to each other, and it is respectively equipped with waist-shaped hole (113) on this two location side plate (112), waist-shaped holes (113) on two location side plate (112) are mutually communicated, and described positioning bar (121) is provided with and positions the hole, location (123) that on side plate (112), the height and position of waist-shaped hole is suitable.
4. the device of laboratory animal simulation people actively smoking effect as claimed in claim 3, it is characterised in that: described slide block (15) upper end is provided with two boss (151), and the guide finger (120) of described baffle plate (12) is articulated with between two boss (151).
5. the device of laboratory animal simulation people actively smoking effect as claimed in claim 1, it is characterized in that: described base plate is provided with chute (14), slide block (15) slides and is located in this chute (14), baffle plate (12) slides with slide block (15) and moves at housing (11) inner chamber, and moves, by this, the containing cavity that formation is suitable with experimental animals length.
6. the device of laboratory animal simulation people actively smoking effect as claimed in claim 1, it is characterized in that: the taper of housing (11) front end is shunk, form the bucket shape chamber (114) accommodating laboratory animal head, bucket shape chamber (114) front end is provided with the first through hole, and baffle plate (12) is provided with the second through hole (124) for placing laboratory animal afterbody.
7. the device of laboratory animal simulation people actively smoking effect as claimed in claim 1, it is characterized in that: described animal per os Smoking pipe (2) includes being responsible for (20), arm (21) and spring (22), arm described in two (21) is connected with an opening of supervisor (20), and spring (22) is connected between two arms (21).
8. the device of laboratory animal simulation people actively smoking effect as claimed in claim 7, it is characterized in that: on described arm (21), be bonded with connection boss (24), the sidewall of this connection boss (24) is provided with the connecting hole (242) for connecting spring (22), and the side end face connecting boss (24) is provided with and the suitable arc groove of arm (21) outer wall (241).
9. the device of laboratory animal simulation people actively smoking effect as claimed in claim 8, it is characterized in that: all inwardly bending of the two ends of described spring (22) also forms bending part (220), the two ends of spring (22) are sheathed on two connection boss (24), and the bending part (220) of spring (22) is connected in the connecting hole (242) connecting boss (24).
10. the device of laboratory animal simulation people actively smoking effect as claimed in claim 9, it is characterized in that: described arm (21) is the cylinder that one end open one end is closed, the opening of arm (21) is connected with the opening of supervisor (20), is provided with some fumaroles (23) on the sidewall of arm (21) and along a tube axis direction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610010429.8A CN105455220B (en) | 2016-01-08 | 2016-01-08 | A kind of device of laboratory animal simulation people actively smoking effect |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610010429.8A CN105455220B (en) | 2016-01-08 | 2016-01-08 | A kind of device of laboratory animal simulation people actively smoking effect |
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| Publication Number | Publication Date |
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| CN105455220A CN105455220A (en) | 2016-04-06 |
| CN105455220B true CN105455220B (en) | 2016-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610010429.8A Active CN105455220B (en) | 2016-01-08 | 2016-01-08 | A kind of device of laboratory animal simulation people actively smoking effect |
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| CN109157301A (en) * | 2018-11-01 | 2019-01-08 | 河西学院 | A kind of medical research experimental apparatus for small animals |
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| CN104720926A (en) * | 2015-04-08 | 2015-06-24 | 中国医学科学院北京协和医院 | Animal passive smoking experiment device |
| RU153429U1 (en) * | 2015-03-11 | 2015-07-20 | Артем Викторович Ларченко | DEVICE FOR STUDYING THE ACTION OF SMOKING MIXTURES ON ANIMALS |
| CN104856781A (en) * | 2015-06-17 | 2015-08-26 | 徐向前 | Experimental animal smudging molding box and molding method thereof |
| CN205322543U (en) * | 2016-01-08 | 2016-06-22 | 南京市口腔医院 | Device of experimental animals anthropomorphic dummy initiative smoking effect |
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2016
- 2016-01-08 CN CN201610010429.8A patent/CN105455220B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3827243B1 (en) * | 2005-05-20 | 2006-09-27 | 優章 荒井 | Cyclone air purifier |
| CN201404307Y (en) * | 2009-05-19 | 2010-02-17 | 江苏省人民医院 | Animal smoking device |
| CN202950790U (en) * | 2012-11-13 | 2013-05-29 | 天津开发区合普工贸有限公司 | Animal experiment device of producing of passive smoking through smoking with human mouths |
| RU153429U1 (en) * | 2015-03-11 | 2015-07-20 | Артем Викторович Ларченко | DEVICE FOR STUDYING THE ACTION OF SMOKING MIXTURES ON ANIMALS |
| CN104720926A (en) * | 2015-04-08 | 2015-06-24 | 中国医学科学院北京协和医院 | Animal passive smoking experiment device |
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| CN205322543U (en) * | 2016-01-08 | 2016-06-22 | 南京市口腔医院 | Device of experimental animals anthropomorphic dummy initiative smoking effect |
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| CN105455220A (en) | 2016-04-06 |
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Effective date of registration: 20201111 Address after: Building 7, Lane 388, Galileo Road, Pudong New Area, Shanghai, 201203 Patentee after: PHARMALEGACY LABORATORIES (SHANGHAI) Co.,Ltd. Address before: 210008, No. 30, Central Road, Xuanwu District, Jiangsu, Nanjing Patentee before: NANJING STOMATOLOGICAL Hospital |
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Address after: Building 7, Lane 388, Galileo Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai, 201203 Patentee after: Pengli biomedical technology (Shanghai) Co.,Ltd. Address before: 201203 building 7, Lane 388, Galileo Road, Pudong New Area, Shanghai Patentee before: PHARMALEGACY LABORATORIES (SHANGHAI) CO.,LTD. |
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