CN105455220A - Device for stimulating human active smoking effect through experimental animal - Google Patents
Device for stimulating human active smoking effect through experimental animal Download PDFInfo
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- CN105455220A CN105455220A CN201610010429.8A CN201610010429A CN105455220A CN 105455220 A CN105455220 A CN 105455220A CN 201610010429 A CN201610010429 A CN 201610010429A CN 105455220 A CN105455220 A CN 105455220A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a device for stimulating the human active smoking effect through an experimental animal. The device comprises a cigarette smoke generator and further comprises an animal per os smoking tube and a fixator for limiting motion of the experimental animal. One end of the animal per os smoking tube is connected with the cigarette smoke generator, and the other end of the animal per os smoking tube stretches into the oral cavity of the experimental animal in the fixator. The fixator comprises a shell, a baffle, a sliding block and a bottom plate provided with a sliding groove. The shell is fixedly connected to the bottom plate, the sliding block is arranged in the sliding groove of the bottom plate in a sliding mode, the baffle is hinged to the sliding block, and an inner cavity of the shell is closed. The device is convenient to operate and fix and simple in structure.
Description
technical field:
The present invention relates to the device of a kind of animal used as test simulation people active smoking effect.
background technology:
Animal smoking model is the important carrier of smoking relevant disease research, in the pathogenesis and treatment of Induced By Tobacco Smoke disease, play extremely crucial effect in research.
Animal used as test is placed in the container that is full of smoke from cigarette by the existing animal smoking model overwhelming majority, under animal used as test body surface is placed in smoky environment completely, smoke from cigarette via intranasal application is sucked in lung by autonomous respiration mode by animal, realizes animal breath system or body surface exposure smog.Smoke from cigarette can not directly be delivered in the oral cavity of animal used as test by this kind of mode, but animal via nose breathing simulates people's passive smoking process by experiment, so the experimental data drawn can not simulate the effect of people's active smoking.Initiatively smoking animal model makes animal pass through the mode of sucking by smoke from cigarette direct oral cavity suction body by experimental provision and animal used as test smoking addiction, simulates people's initiatively smoking effect substantially.
In addition, when animal used as test simulation people initiatively test by smoking, need to be fixed on by animal used as test in a fixator, existing fixer structure is complicated, often needs multiple experimenter to work in coordination, animal could be fixed.
Therefore, necessary the deficiency solving prior art is improved to prior art.
summary of the invention:
The present invention provides a kind of animal used as test to simulate the device of people's active smoking effect to solve above-mentioned prior art Problems existing.
The technical solution adopted in the present invention has: a kind of device of animal used as test simulation people active smoking effect, comprise smoke from cigarette generator, also comprise animal per os Smoking pipe and the fixator for limiting animal used as test activity, one end of described animal per os Smoking pipe is connected with smoke from cigarette generator, and the other end stretches in the oral cavity of animal used as test in fixator;
Described fixator comprises housing, baffle plate, slide block and base plate, described housing is fixedly connected on base plate, baffle plate to be positioned on rear side of housing and to be articulated with on slide block, move with slide block, and opened by the motion of relative housing or the inner chamber of closure shell, formed with place the accommodating cavity of experimental animals appearance adaptation.
Further, the upper and lower symmetrical both sides of described housing are respectively equipped with locating slot and gathering sill, described baffle plate be provided with respectively with gathering sill and the suitable guide finger of locating slot and positioning bar, guide finger and positioning bar are slidably arranged in gathering sill and locating slot respectively.
Further, the cell wall place, both sides corresponding to locating slot on the upside of described housing is respectively equipped with the location side plate be parallel to each other, and waist-shaped hole is respectively equipped with on this two location side plate, waist-shaped hole on two location side plates is mutually through, and described positioning bar is provided with and locates the locating hole that on side plate, the height and position of waist-shaped hole is suitable.
Further, described upper end of slide block is provided with two boss, and the guide finger of described baffle plate is articulated with between two boss.
Further, described base plate is provided with chute, and skid is located in this chute, and baffle plate moves at housing cavity with skid, and moves by this accommodating cavity formed with experimental animals appearance adaptation.
Further, housing forward end taper is shunk, and form the bucket shape chamber holding laboratory animal head, front end, bucket shape chamber is provided with the first through hole, and baffle plate is provided with the second through hole for placing animal used as test afterbody.
Further, described animal per os Smoking pipe comprises supervisor, arm and spring, and arm described in two is connected with an openend of supervisor, and spring is connected between two arms.
Further, described arm is bonded with connection boss, the sidewall of this connection boss is provided with the connecting hole for linking springs, and the side end face connecting boss is provided with arc groove suitable with arm outer wall.
Further, all inwardly bending form bending part of the two ends of described spring, the two ends of spring are sheathed on two connection boss, and the bending part of spring be connected in connect boss connecting hole in.
Further, described arm is the cylinder that one end open one end is closed, and the openend of arm is connected with the openend of supervisor, and the sidewall of arm is provided with some fumaroles along propping up on tube axis direction.
Animal used as test is placed in fixator, one end of animal per os Smoking pipe is connected with smoke from cigarette generator, the other end stretches in the oral cavity of animal used as test in fixator, spring is provided with between two arms of animal per os Smoking pipe one end, after arm being placed in animal used as test oral cavity, unclamp arm, two arms under spring force, two arms discharge and are supported in animal used as test oral cavity in animal used as test oral cavity, and animal per os Smoking pipe can not depart from the oral cavity of animal used as test due to the struggle of animal used as test; Due to animal in a reservoir have proal front taxis, after in fixator animal being placed in the present invention, only need by barrier slides in fixator, then animal can be confined in fixator by cross-under bolt, consequent beneficial effect is: convenient operation of the present invention, good fixing effect, only need an experimenter animal can be fixed, directly animal per os Smoking pipe arm is placed in animal used as test oral cavity, the experimental data drawn is accurate, can maximize the effect of simulation people active smoking.
accompanying drawing illustrates:
Fig. 1 is the structure chart of apparatus of the present invention.
Fig. 2 is the right TV structure figure of fixator in the present invention.
Fig. 3 is the top view (wherein base plate is positioned at the end of housing) of fixator in the present invention.
Fig. 4 is the baffle plate Unclosing structure figure of fixator in the present invention.
Fig. 5 is the structure chart that in the present invention, base plate is arranged in housing cavity.
Fig. 6 is animal per os Smoking pipe structure chart in the present invention.
Fig. 7 connects the sectional view of boss on arm in Fig. 6.
Fig. 8 is the partial enlarged drawing of thing per os Smoking pipe in Fig. 6.
detailed description of the invention:
Below in conjunction with accompanying drawing, the present invention is further illustrated.
As shown in Figure 1, the device of a kind of animal used as test simulation of the present invention people active smoking effect, comprise animal per os Smoking pipe 2, smoke from cigarette generator 3 and the fixator 1 for limiting animal used as test activity, one end of animal per os Smoking pipe 2 is connected with smoke from cigarette generator 3, and the other end stretches in the oral cavity of animal used as test in fixator 1.
Composition graphs 2 and Fig. 3, comprise baffle plate 12, base plate 13, slide block 15 and be provided with the housing 11 of inner chamber, housing 11 is fixedly connected with on base 13 by gripper shoe 4, baffle plate 12 is positioned at the rear side of housing 11 and is articulated with on slide block 15, move with slide block 15, and opened by the motion of relative housing 11 or the inner chamber of closure shell 11, formed with place the accommodating cavity of experimental animals appearance adaptation.
Gathering sill 110 and locating slot 111 is respectively equipped with in the symmetrical up and down both sides of housing 11, baffle plate 12 is provided with respectively with gathering sill 110 and the suitable guide finger 120 of locating slot 111 and positioning bar 121, guide finger 120 and positioning bar 121 are slidably arranged in gathering sill 110 and locating slot 111 respectively.
On housing 11 and the both sides being positioned at locating slot 111 are provided with location side plate 112, this two location side plate 112 is respectively equipped with waist-shaped hole 113, and the waist-shaped holes 113 on two location side plates 112 are mutually through.
Positioning bar 121 is provided with the locating hole 123 suitable with the height and position of locating waist-shaped hole on side plate 112.
The present invention, for ease of baffle plate 12 slip on base 13, is provided with chute 14 on base 13, and slide block 15 is slidably connected in this chute 14, is provided with two boss 151 in slide block 15 upper end, the guide finger 120 of baffle plate 12 by hinge between these two boss 151.
As Fig. 4 and Fig. 5, open baffle plate 12, the inner chamber of housing 11 is opened, as animal used as test is put under this kind of state, forerunner's property of animal used as test makes it enter in housing 11 along baffle plate 12, rotate and moving stop 12, the inner chamber of baffle plate 12 closure shell 11, promoting baffle plate 12 makes it slide along the gathering sill 110 on housing 11 and locating slot 111, after adjusting to the suitable position of body body length with animal used as test, by bolt cross-under waist-shaped hole 113 and the rear fastening nuts of locating hole 123, baffle plate 12 is fixed, thus animal used as test is fixed in the inner chamber of housing 11.
Housing 11 in the present invention is the column construction of both ends open, the front end taper of housing 11 is shunk, form the bucket shape chamber 114 holding laboratory animal head, front end, bucket shape chamber 114 is provided with the first through hole, and baffle plate 12 is provided with the second through hole 124 for placing animal used as test afterbody.
As Fig. 6 and Fig. 7, animal per os Smoking pipe 2 in the present invention comprises supervisor 20 and arm 21, two arms 21 are connected with an openend of supervisor 20, two arms 21 are equipped with columniform connection boss 24, the sidewall of this connection boss 24 is provided with connecting hole 242, the side end face connecting boss 24 is provided with arc groove 241, and this arc groove 241 is suitable with the outer wall of arm 21.When connection boss 24 is adhered on arm 21, the corresponding position spreading glue on arm 21 sidewall, and in the arc groove 241 connecting boss 24 also spreading glue, thus connection boss 24 to be bonded on arm 21.
As Fig. 8, the all inwardly bending be formed with bending part 220 of two ends up and down of the spring 22 in the present invention, when spring 22 is connected between two arms 21, spring 22 two ends are sheathed on two connection boss 24, and the bending part 220 of spring 22 liang of ends are connected in the connecting hole 242 on connection boss 24.
The cylindrical structure that arm 21 in the present invention is closed for one end open one end, the openend of arm 21 is connected with the openend of supervisor 20, the sidewall of every root arm 21 is equipped with some fumaroles 23, fumarole 23 is arranged along arm 21 axis direction, and fumarole 23 is uniformly distributed in the non-outside of arm end.Smoke from cigarette can be full of the oral cavity of animal by fumarole 23 fully that open on arm 21 sidewall.
When carrying out the zoopery of simulating people's active smoking, clutch two arms 21 and holddown spring 22, after arm 21 is placed in animal used as test oral cavity, unclamp arm 21, spring 22 recoils to original position, two arms 21 discharge and are supported in animal used as test oral cavity in animal used as test oral cavity, and under spring force, animal used as test cannot shake off the animal per os Smoking pipe 2 in oral cavity.
The above is only the preferred embodiment of the present invention, it should be pointed out that for those skilled in the art, can also make some improvement under the premise without departing from the principles of the invention, and these improvement also should be considered as protection scope of the present invention.
Claims (10)
1. the device of an animal used as test simulation people active smoking effect, comprise smoke from cigarette generator (3), it is characterized in that: also comprise animal per os Smoking pipe (2) and the fixator (1) for limiting animal used as test activity, one end of described animal per os Smoking pipe (2) is connected with smoke from cigarette generator (3), and the other end stretches in the oral cavity of fixator (1) interior animal used as test;
Described fixator (1) comprises housing (11), baffle plate (12), slide block (15) and base plate (13), described housing (11) is fixedly connected on base plate (13), baffle plate (12) is positioned at housing (11) rear side and is articulated with on slide block (15), mobile with slide block (15), and opened by the motion of relative housing (11) or the inner chamber of closure shell (11), formed with place the accommodating cavity of experimental animals appearance adaptation.
2. the device of animal used as test simulation people active smoking effect as claimed in claim 1, it is characterized in that: the upper and lower symmetrical both sides of described housing (11) are respectively equipped with locating slot (111) and gathering sill (110), described baffle plate (12) be provided with respectively with gathering sill (110) and the suitable guide finger (120) of locating slot (111) and positioning bar (121), guide finger (120) and positioning bar (121) are slidably arranged in gathering sill (110) and locating slot (111) respectively.
3. the device of animal used as test simulation people active smoking effect as claimed in claim 2, it is characterized in that: the cell wall place, both sides that described housing (11) upside corresponds to locating slot (111) is respectively equipped with the location side plate (112) be parallel to each other, and waist-shaped hole (113) is respectively equipped with on this two location side plate (112), waist-shaped hole (113) on two location side plate (112) is mutually through, and described positioning bar (121) is provided with the locating hole (123) suitable with the height and position of locating the upper waist-shaped hole of side plate (112).
4. the device of animal used as test simulation people active smoking effect as claimed in claim 3, it is characterized in that: described slide block (15) upper end is provided with two boss (151), the guide finger (120) of described baffle plate (12) is articulated with between two boss (151).
5. the device of animal used as test simulation people active smoking effect as claimed in claim 1, it is characterized in that: described base plate is provided with chute (14), slide block (15) slides and is located in this chute (14), baffle plate (12) slides with slide block (15) and moves at housing (11) inner chamber, and moves by this accommodating cavity formed with experimental animals appearance adaptation.
6. the device of animal used as test simulation people active smoking effect as claimed in claim 1, it is characterized in that: the taper of housing (11) front end is shunk, form the bucket shape chamber (114) holding laboratory animal head, bucket shape chamber (114) front end is provided with the first through hole, and baffle plate (12) is provided with the second through hole (124) for placing animal used as test afterbody.
7. the device of animal used as test simulation people active smoking effect as claimed in claim 1, it is characterized in that: described animal per os Smoking pipe (2) comprises supervisor (20), arm (21) and spring (22), arm described in two (21) is connected with an openend of supervisor (20), and spring (22) is connected between two arms (21).
8. the device of animal used as test simulation people active smoking effect as claimed in claim 7, it is characterized in that: described arm (21) is bonded with and connects boss (24), the sidewall of this connection boss (24) is provided with the connecting hole (242) for linking springs (22), and the side end face connecting boss (24) is provided with and the suitable arc groove of arm (21) outer wall (241).
9. the device of animal used as test simulation people active smoking effect as claimed in claim 8, it is characterized in that: all inwardly bending form bending part (220) of the two ends of described spring (22), the two ends of spring (22) are sheathed on two connection boss (24), and the bending part (220) of spring (22) is connected in the connecting hole (242) of connection boss (24).
10. the device of animal used as test simulation people active smoking effect as claimed in claim 9, it is characterized in that: the cylinder that described arm (21) is closed for one end open one end, the openend of arm (21) is connected with the openend of supervisor (20), and the sidewall of arm (21) is provided with some fumaroles (23) on tube axis direction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610010429.8A CN105455220B (en) | 2016-01-08 | 2016-01-08 | A kind of device of laboratory animal simulation people actively smoking effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610010429.8A CN105455220B (en) | 2016-01-08 | 2016-01-08 | A kind of device of laboratory animal simulation people actively smoking effect |
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| Publication Number | Publication Date |
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| CN105455220A true CN105455220A (en) | 2016-04-06 |
| CN105455220B CN105455220B (en) | 2016-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610010429.8A Active CN105455220B (en) | 2016-01-08 | 2016-01-08 | A kind of device of laboratory animal simulation people actively smoking effect |
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| CN (1) | CN105455220B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109157301A (en) * | 2018-11-01 | 2019-01-08 | 河西学院 | A kind of medical research experimental apparatus for small animals |
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| CN104720926A (en) * | 2015-04-08 | 2015-06-24 | 中国医学科学院北京协和医院 | Animal passive smoking experiment device |
| RU153429U1 (en) * | 2015-03-11 | 2015-07-20 | Артем Викторович Ларченко | DEVICE FOR STUDYING THE ACTION OF SMOKING MIXTURES ON ANIMALS |
| CN104856781A (en) * | 2015-06-17 | 2015-08-26 | 徐向前 | Experimental animal smudging molding box and molding method thereof |
| CN205322543U (en) * | 2016-01-08 | 2016-06-22 | 南京市口腔医院 | Device of experimental animals anthropomorphic dummy initiative smoking effect |
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2016
- 2016-01-08 CN CN201610010429.8A patent/CN105455220B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3827243B1 (en) * | 2005-05-20 | 2006-09-27 | 優章 荒井 | Cyclone air purifier |
| CN201404307Y (en) * | 2009-05-19 | 2010-02-17 | 江苏省人民医院 | Animal smoking device |
| CN202950790U (en) * | 2012-11-13 | 2013-05-29 | 天津开发区合普工贸有限公司 | Animal experiment device of producing of passive smoking through smoking with human mouths |
| RU153429U1 (en) * | 2015-03-11 | 2015-07-20 | Артем Викторович Ларченко | DEVICE FOR STUDYING THE ACTION OF SMOKING MIXTURES ON ANIMALS |
| CN104720926A (en) * | 2015-04-08 | 2015-06-24 | 中国医学科学院北京协和医院 | Animal passive smoking experiment device |
| CN104856781A (en) * | 2015-06-17 | 2015-08-26 | 徐向前 | Experimental animal smudging molding box and molding method thereof |
| CN205322543U (en) * | 2016-01-08 | 2016-06-22 | 南京市口腔医院 | Device of experimental animals anthropomorphic dummy initiative smoking effect |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109157301A (en) * | 2018-11-01 | 2019-01-08 | 河西学院 | A kind of medical research experimental apparatus for small animals |
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| CN105455220B (en) | 2016-11-30 |
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Effective date of registration: 20201111 Address after: Building 7, Lane 388, Galileo Road, Pudong New Area, Shanghai, 201203 Patentee after: PHARMALEGACY LABORATORIES (SHANGHAI) Co.,Ltd. Address before: 210008, No. 30, Central Road, Xuanwu District, Jiangsu, Nanjing Patentee before: NANJING STOMATOLOGICAL Hospital |
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Address after: Building 7, Lane 388, Galileo Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai, 201203 Patentee after: Pengli biomedical technology (Shanghai) Co.,Ltd. Address before: 201203 building 7, Lane 388, Galileo Road, Pudong New Area, Shanghai Patentee before: PHARMALEGACY LABORATORIES (SHANGHAI) CO.,LTD. |
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