CN214593499U

CN214593499U - Mouse binding device

Info

Publication number: CN214593499U
Application number: CN202120456060.XU
Authority: CN
Inventors: 孙文智
Original assignee: Beijing Brain Science And Brain Like Research Center
Current assignee: Beijing Brain Science And Brain Like Research Center
Priority date: 2021-03-03
Filing date: 2021-03-03
Publication date: 2021-11-05
Anticipated expiration: 2031-03-03

Abstract

The utility model discloses a mouse constraint device, including a plurality of constraint pipes that are used for the holding mouse and the constraint pipe support that is used for placing the constraint pipe, the constraint pipe support is flat structure, and one side of constraint pipe support is the bottom surface, and one side parallel arrangement of the relative bottom surface of constraint pipe support has a plurality of recesses that hold, and the constraint pipe corresponds the setting in holding the recess. The utility model discloses a constraint pipe has realized the good constraint to the mouse, and the constraint pipe support can be fixed a plurality of constraint pipes simultaneously, prevents that the constraint pipe from taking place to roll, is favorable to carrying out multiunit mouse model experiment. The utility model has the characteristics of simple structure, the constraint is effectual and convenient and practical.

Description

Mouse binding device

Technical Field

The utility model relates to an animal for the experiments constraint ware correlation technique field especially relates to a mouse constraint device.

Background

In the field of biological zoology research, it is often desirable to construct mouse models (such as depression models or PTSD models) involving tethered devices. Currently, the conventional method is to place the experimental mouse into a 50ml tip centrifuge tube for binding, and cut a notch at the top of the centrifuge tube to allow the mouse to breathe. Conventional mice currently being modeled typically weigh about 18-22 grams for 6-8 weeks, using centrifuge tubes of a diameter larger than the body axis of the mouse. The mouse can still move in the tube in a small amplitude, the binding strength can not meet the experimental requirement, and the effect of constructing the model is influenced to a certain extent. And the top opening tangent plane of centrifuging tube is comparatively sharp, fish tail mouse oronasal easily, has the infection risk, brings the interference for the experimental result. Triangular bag restraint is also a common method, but easily squeezes the thorax, viscera and tail of the mouse, causes physiological damage to the mouse, and also easily causes suffocation and death of the mouse. Simultaneously, if need the mouse of a large amount to tie in the experimentation, just need use multiunit constraint device, how firm placing avoids the roll of constraint pipe to wait to solve urgently also.

Based on the above problems, it is desirable to provide a binding device that is both safe and capable of achieving a binding effect.

SUMMERY OF THE UTILITY MODEL

Technical problem to be solved

An object of the utility model is to provide a mouse constraint device can carry out the experiment of a great amount of mouse constraints simultaneously to ensure the firm of constraint pipe and place.

(II) technical scheme

In order to solve the problem, the utility model adopts the following technical scheme: the utility model provides a mouse constraint device, manage and be used for placing including a plurality of constraints that are used for the holding mouse the constraint pipe support of constraint pipe, the constraint pipe support is flat structure, and one side of constraint pipe support is the bottom surface, and one side parallel arrangement of the relative bottom surface of constraint pipe support has a plurality of recesses that hold, the constraint pipe corresponds the setting and is in hold in the recess.

Optionally, the constraint pipe includes the constraint pipe body and the tube head of integrative setting, the tube head is the cone, holding groove is the rectangle recess be provided with on holding groove's the front end lateral wall with the sunken arc of the outer wall looks adaptation of tube head, the setting of coincideing of constraint pipe is in hold in the recess.

Optionally, be provided with in the constraint pipe and link up the tube head with the constraint cavity of constraint pipe body, the constraint cavity is including setting up conical cavity in the tube head is in with the setting cylindrical cavity in the constraint pipe body, be provided with on the top of tube head and the tube head lateral wall with the mouse of constraint cavity and external intercommunication breathes the trompil, the other end of keeping away from the tube head of constraint pipe body is provided with detachable, is used for sealing the closed base of constraint cavity be provided with the tail hole that supplies the mouse tail to pass on the closed base.

Optionally, the closed base comprises a bottom plate and a circular boss arranged on the bottom plate, tail outlet holes are correspondingly arranged on the bottom plate and the circular boss, and the circular boss is matched, sealed and inserted at the end of the cylindrical cavity.

Optionally, one side of the bottom plate, which is away from the circular boss, is in planar contact with the inner side of the rear end side wall of the accommodating groove, and a via hole corresponding to the tail outlet hole in the bottom plate is formed in the rear end side wall of the accommodating groove.

Alternatively, the diameter of the cylindrical cavities of the plurality of restraining tubes for receiving mice can be selected to fit mice of different volumes.

Optionally, the height of the circular boss can be selected to adjust and limit the moving space of the mouse in the restraint tube.

Optionally, the side wall surfaces of the conical cavity and the cylindrical cavity are smooth surfaces, the maximum diameter of the conical cavity is the same as the diameter of the cylindrical cavity, and the conical cavity is in smooth transition connection with the cylindrical cavity.

Optionally, the mouse breathing opening on the side wall of the tube head is provided with a plurality of openings.

Optionally, the binding pipe frame and the closed base are all 3D printed and integrally formed.

(III) advantageous effects

The utility model discloses a mouse binding device, a plurality of binding pipes are stably arranged on the binding pipe frame of the utility model, and the binding pipes can be effectively prevented from rolling; and multiple groups of mouse binding model experiments can be carried out simultaneously. The utility model has the characteristics of simple structure, the constraint is effectual and convenient and practical.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It is obvious that the drawings in the following description are only some embodiments of the invention, and that for a person skilled in the art, other drawings can be derived from them without inventive effort.

Fig. 1 is a schematic structural view of a mouse restraint device provided by the present invention;

figure 2 is a top view of the mouse restraint device shown in figure 1;

fig. 3 is a cross-sectional view of a restraint tube in the mouse restraint device provided by the present invention;

fig. 4 is a schematic structural view of a closed base in a mouse binding device provided by the present invention;

fig. 5 is a schematic structural view of a restraint pipe frame in the mouse restraint device provided by the present invention;

fig. 6 is a schematic view of a bottom plate structure of a closed base in a mouse binding device provided by the present invention.

The reference numbers in the drawings are, in order:

1-bounding tube, 2-bounding tube holder, 21-bottom, 3-containing groove, 31-front side wall, 32-back side wall, 4-tube head, 5-bounding tube body, 6-closed base, 7-mouse breathing open hole, 8-bottom plate, 81-semicircular part, 82-rectangular part, 9-circular boss, 10-tail hole, 11-bounding cavity, 12-cylindrical cavity, 13-conical cavity, 14-via hole.

Detailed Description

The following describes the present invention in further detail with reference to the following examples and drawings. The following examples of the present invention are provided to illustrate the present invention, but are not intended to limit the scope of the present invention.

As shown in fig. 1, a mouse restraint device comprises a plurality of restraint pipes 1 for accommodating mice and a restraint pipe frame 2 for placing the restraint pipes 1, wherein the restraint pipe frame 2 is of a flat structure, one side of the restraint pipe frame 2 is a bottom surface 21, a plurality of accommodating grooves 3 are arranged in parallel on one side of the restraint pipe frame 2 opposite to the bottom surface 21, and the restraint pipes 1 are correspondingly arranged in the accommodating grooves 3. The binding pipe frame 2 is of a flat structure, and the bottom surface 21 of the binding pipe frame is a plane, so that stable placement can be ensured; the binding pipe 1 is arranged in the accommodating groove 3, so that the binding pipe 1 is fixed, and the binding pipe 1 can be effectively prevented from rolling; set up a plurality of constraint pipes 1 on constraint pipe support 2, can carry out the multiunit simultaneously and test, still be favorable to practicing thrift the space and place in groups.

Optionally, in fig. 1, five accommodating grooves 3 are provided on the tie-pipe frame 2, and five tie-pipes 1 can be correspondingly placed. Of course, the number of the receiving grooves 3 is not limited to five, and the number of the receiving grooves 3 may be set according to experimental habits. It can be seen that, a constraint pipe support 2 can realize fixed to a plurality of constraint pipes 1, has improved fixed efficiency, is favorable to carrying out the experiment of multiunit mouse model.

Referring to fig. 2, 3 and 5, the tether tube 1 includes a tether tube body 5 and a tube head 4 integrally formed, and the tube head 4 has a conical shape. The accommodating groove 3 is a rectangular groove, and a concave arc matched with the outer wall of the tube head 4 is arranged on the side wall 31 at the front end of the accommodating groove 3. The binding tube 1 is arranged in the accommodating groove 3 in an inosculating manner, and the binding tube 1 can be better fixed by adopting the structure to avoid rolling.

Referring to fig. 3, a binding cavity 11 penetrating through the tube head 4 and the binding tube body 5 is arranged in the binding tube 1, the binding cavity 11 is composed of a conical cavity 13 arranged in the tube head 4 and a cylindrical cavity 12 arranged in the binding tube body 5, and the conical cavity 13 is used for binding the head of a mouse; the cylindrical cavity 12 is used to restrain the body of the mouse. The side wall surfaces of the conical cavity 13 and the cylindrical cavity 12 are smooth surfaces, so that the mice can be effectively prevented from being damaged in the experimental process.

Preferably, the maximum diameter of the conical cavity 13 is the same as the diameter of the cylindrical cavity 12, and the conical cavity 13 and the cylindrical cavity 12 are connected in a smooth transition manner, so that the mice can be protected from being damaged.

The other end of the binding tube body 5, which is far away from the tube head 4, is provided with a detachable closed base 6 for closing the binding cavity 11, and the closed base 6 is provided with a tail outlet hole 10 for allowing a mouse tail to pass through. The tail outlet hole 10 penetrates through the whole closed base 6, and when the closed base 6 is matched with the binding pipe 1 for use, the tail of the mouse penetrates out of the tail outlet hole 10, so that the tail of the mouse cannot be extruded in the binding process.

Preferably, the closed base 6 is arranged in the accommodating groove 3 and is in press fit with the inner side surface plane of the rear end side wall 32 of the accommodating groove 3, so that the closed base 6 can be effectively prevented from falling off due to the movement of a mouse in the experimental process.

With reference to fig. 4 and 6, the sealing base 6 includes a bottom plate 8 and a circular boss 9 disposed on the bottom plate 8, and tail holes 10 are correspondingly disposed on the bottom plate 8 and the circular boss 9.

The circular boss 9 is matched, sealed and inserted at the end part of the cylindrical cavity 12, and can seal the tail end of the cylindrical cavity 12 to prevent the mouse from escaping. The sealing is carried out by adopting a plug-in mounting mode, and the sealing and the fixing can be conveniently realized without complex mechanical connection modes such as threads and the like.

The rear end side wall 32 of the receiving groove 3 is provided with a through hole 14 corresponding to the tail hole 10 of the base plate 8, and the through hole 14 may be designed in a semicircular shape or other arc shapes. The purpose is to extract the tail of the mouse and prevent the tail of the mouse from being squeezed.

Alternatively, the bottom plate 8 comprises a semicircular part 81 and a rectangular part 82, the diameter of the semicircular part 81 is consistent with that of the binding tube body 5, and the shape and size of the bottom plate 8 are consistent with that of the end part of the binding tube body 5 far away from the tube head. The side of the base plate 8 facing away from the circular projection 9 is in planar contact with the inner side of the rear end side wall 32 of the receiving recess 3.

The top end of the tube head 4 and the side wall of the tube head 4 are provided with mouse breathing holes 7 which are used for communicating the bound cavity 11 with the outside. The mouse breathing hole 7 is beneficial to normal breathing of the mouse, so that the mouse is prevented from suffocation death, and water vapor generated by breathing of the mouse can be reduced.

Optionally, the mouse breathing openings 7 in the side wall of the cartridge 4 are provided in a plurality and are evenly distributed around the central axis of the cartridge 4 in the side wall of the cartridge 4.

Optionally, the shape of the mouse respiratory opening 7 is circular or elliptical.

Alternatively, the diameter of the cylindrical cavity 12 of the plurality of restraining tubes 1 for housing a mouse can be selected to fit different volumes of mouse, of course it is necessary to ensure that the maximum diameter of the conical cavity 13 communicating with the cylindrical cavity 12 is the same as the diameter of the cylindrical cavity 12.

The size of the volume is not exactly the same due to individual differences among the mice during the experiment. The diameter of the selected cylindrical cavity 12 is too large, so that the mouse can still move in the binding tube 1 in a small range, and the binding requirement cannot be met; the diameter of the cylindrical cavity 12 is selected to be too small, which may damage the mouse and affect the experimental results. Therefore, when selecting the cylindrical cavity 12, the cylindrical cavities 12 with different diameters are reasonably selected according to the volume of the mouse so as to meet the binding requirement.

Alternatively, when the diameter of the cylindrical cavity 12 is selected, the outer diameter of the tether tube body 5 may also vary following the variation in the diameter of the cylindrical cavity 12. Namely, when the diameter of the cylindrical cavity 12 is smaller, the outer diameter of the binding pipe body 5 is smaller; when the diameter of the cylindrical cavity 12 is larger, the outer diameter of the binding tube body 5 is also larger. The wall thickness between the crimp tube body 5 and the cylindrical cavity 12 is relatively consistent. Correspondingly, the accommodating groove 3 on the restraint pipe frame 2 can be set to be different according to the sizes of different restraint pipes 1.

Of course, when the diameter of the cylindrical cavity 12 is chosen, the outer diameter of the crimp tube body 5 may also be constant, i.e. not follow the change in diameter of the cylindrical cavity 12. This kind of mode is convenient for set up the holding groove 3 of unified size on the restraint pipe support 2, no matter what the diameter of cylindrical cavity 12 chooses, and restraint pipe 1 all can place at will the selection holding groove 3 on restraint pipe support 2.

Alternatively, the height of the circular boss 9 may be selected to adjust the space for restraining the mouse within the restraining tube 1. When the height of the selected round boss 9 is lower, the moving space of the mouse in the binding tube 1 is enlarged, and the binding requirement cannot be met. When the height of the selected circular boss 9 is higher, the mouse is squeezed in the restraint tube 1, and the experimental result is influenced. The height of the circular boss 9 should be selected appropriately according to the size of the mouse.

Optionally, the end surface of the circular boss 9 is smooth, so that the mouse can be protected from being damaged.

Optionally, for the circular bosses 9 with different projection heights, the closed base 6 can be correspondingly provided with a plurality of types, and the connection mode of the circular bosses 9 and the bottom plate 8 is fixed connection and cannot be detached. Of course, the circular boss 9 can also be detachably mounted on the bottom plate 8, for example, by a clamping manner, etc., and the circular boss 9 with different protruding heights can be conveniently replaced by the clamping manner, so that the advantage of saving the use amount of the closed base 6 is achieved.

Optionally, the above binding pipe 1, binding pipe frame 2 and closed base 6 are all 3D printed and integrally formed.

The working principle of the mouse restraint device is as follows: in use, firstly, the laboratory technician places the restraint tube rack 2 horizontally, and selects a proper number of restraint tubes 1 according to the experimental requirements. If the number is larger, the binding pipe frames 2 also need to be matched with the binding pipes 1. The mouse is attracted or grabbed into the restraint tube 1, the tip of the inside of the restraint tube 1 is conical, and the head of the mouse can be restrained at a position substantially at this point. The mouse that 4 front ends of tube head of restriction pipe 1 and side set up breathes trompil 7 makes breathing that the mouse can be normal, prevents that the mouse from suffocating the death in the intraductal, also can reduce the steam that the mouse breathes the production simultaneously. After the mouse gets into the constraint pipe 1, pass the tail of mouse earlier and wear out through the tail hole 10 on the closed base 6, later with the open end of closed base 6 cartridge income constraint pipe 1, later place the constraint pipe 1 in the holding groove 3 on the constraint pipe support 2. When the mouse constraint training finishes and needs to take out the mouse, only need to take off from constraint pipe support 2 with constraint pipe 1, take out the closed base 6 of constraint pipe 1, the mouse can drill out constraint pipe 1 by oneself, above be the course of operation of whole device. Those not described in detail in this specification are within the skill of the art.

The utility model discloses a 3D printing mode preparation constraint pipe 1 can rationally confirm the internal diameter size of constraint pipe 1 according to the size of a dimension of experiment mouse, ensures the constraint effect of mouse and can not extrude the mouse tail and influence the experimental result. The closed base 6 is of a circular truncated cone structure, the protruding height of different circular truncated cones can be designed according to the size of a mouse, and therefore the moving space of the mouse is smaller, and therefore a better constraint effect is achieved.

The binding tube 1 and the binding tube frame 2 are matched for use, so that the experiment of a plurality of groups of mouse models can be stably carried out at the same time, and the problems of rolling of the binding tube 1 and the like are avoided; it is also beneficial to save space and group placement.

To sum up, the utility model provides a mouse constraint device and constraint pipe kit who uses rather than the cooperation have simple structure, constraint effectual, place the advantage that facilitates the use, easily preparation and operation can avoid forming the stress of other injury nature to the mouse. 3D prints preparation and restricts the activity space that manages the mouse that can be best restriction mouse and can effectively restrict the mouse, has great spreading value.

In the present invention, the terms such as "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "side", "bottom", and the like indicate the position or positional relationship based on the position or positional relationship shown in the drawings, and are only the terms determined for convenience of describing the structural relationship of each component or element of the present invention, and are not specific to any component or element of the present invention, and are not to be construed as limiting the present invention.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. To those skilled in the art, the specific meaning of the above terms in the present invention can be understood in specific cases, and should not be construed as limiting the present invention.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

The above embodiments are merely illustrative, and not restrictive, of the present invention. Although the present invention has been described in detail with reference to the embodiments, it should be understood by those skilled in the art that various combinations, modifications or equivalent substitutions may be made to the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention, and all of the technical solutions should be covered by the scope of the claims of the present invention.

Claims

1. The utility model provides a mouse constraint device, its characterized in that includes a plurality of constraint pipes that are used for holding the mouse and is used for placing the constraint pipe support of constraint pipe, the constraint pipe support is flat structure, and one side of constraint pipe support is the bottom surface, and one side parallel arrangement of the relative bottom surface of constraint pipe support has a plurality of recesses that hold, the constraint pipe corresponds the setting and is in hold in the recess.

2. The mouse restraint device according to claim 1, wherein the restraint tube comprises a restraint tube body and a tube head which are integrally arranged, the tube head is conical, the accommodating groove is a rectangular groove, a concave arc shape matched with the outer wall of the tube head is arranged on the side wall of the front end of the accommodating groove, and the restraint tube is arranged in the accommodating groove in an inosculating manner.

3. The mouse restraint device according to claim 2, wherein the restraint pipe is internally provided with a through cavity which penetrates the tube head and the restraint pipe body, the restraint cavity comprises a conical cavity arranged in the tube head and a cylindrical cavity arranged in the restraint pipe body, the top end of the tube head and the side wall of the tube head are provided with mouse breathing holes communicated with the outside, the other end of the restraint pipe body, far away from the tube head, is provided with a detachable sealing base for sealing the restraint cavity, and the sealing base is provided with a tail outlet hole for allowing a mouse tail to pass through.

4. The mouse restraint device according to claim 3, wherein the closed base comprises a bottom plate and a circular boss arranged on the bottom plate, tail outlet holes are correspondingly arranged on the bottom plate and the circular boss, and the circular boss is matched, sealed and inserted at the end part of the cylindrical cavity.

5. The mouse restraint device of claim 4, wherein a side of the bottom plate facing away from the circular boss is in planar contact with an inner side of a rear end side wall of the accommodating groove, and a through hole corresponding to the tail outlet hole in the bottom plate is formed in the rear end side wall of the accommodating groove.

6. A mouse restraint device according to claim 3, wherein the diameter of a plurality of cylindrical cavities of the restraint tube for receiving a mouse can be selected to fit mice of different volumes.

7. The mouse restraint device of claim 4, wherein the height of the protrusion of the circular boss is selected to adjustably limit the space within which a mouse moves within the restraint tube.

8. The mouse restraint device of claim 3, wherein the side wall surfaces of the conical cavity and the cylindrical cavity are smooth surfaces, the maximum diameter of the conical cavity is the same as the diameter of the cylindrical cavity, and the conical cavity and the cylindrical cavity are in smooth transition connection.

9. The mouse restraint device of claim 3, wherein the side wall of the cartridge has a plurality of mouse breathing openings.

10. The mouse restraint device of claim 3, wherein the restraint tube, the restraint tube holder, and the closed base are all 3D printed integrally.