CN104840492A - Colloid mill crushing and spray drying combined wall breaking technology of Mythic Fungus spore powder - Google Patents
Colloid mill crushing and spray drying combined wall breaking technology of Mythic Fungus spore powder Download PDFInfo
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- CN104840492A CN104840492A CN201410055657.8A CN201410055657A CN104840492A CN 104840492 A CN104840492 A CN 104840492A CN 201410055657 A CN201410055657 A CN 201410055657A CN 104840492 A CN104840492 A CN 104840492A
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Abstract
A colloid mill crushing and spray drying combined wall breaking technology of Mythic Fungus spore powder comprises the steps of immersion, grinding, broken rate determination and spray drying, and concretely comprises the following steps: adding purified water with the volume 10 times the mass of the Mythic Fungus spore powder, immersing for 30min, stirring to form a suspended state, adding the obtained suspension to a colloid mill, running under a 20[mu]m gap for 30min, running under a 10[mu]m gap for 20min, adding the obtained mixed liquor to a spray drying machine when the broken rate observed under a microscope is greater than 90%, feeding under 40r/min, and drying at 65DEG C to obtain brown wall broken Mythic Fungus spore powder. Fig. 1 in the specification is a process chart.
Description
Technical field
The present invention relates to a kind of cell wall wall breaking technology, particularly relate to a kind of colloid mill for Ganoderma spore powder and pulverize and spraying dry combined wall breakage technology.
Background technology
Ganoderma spore powder has the effect strengthening body immunity, is usually used in auxiliary treatment during cancer chemotherapy.Its effective ingredient has ganoderan class, triterpenes, ucleosides, sterols, alkaloids, furan derivatives, amino acid polypeptide class, mineral element, fatty acid etc.Ganoderma has many-sided pharmacological action, and toxicity is very low, and its pharmacological action has: antitumor, immunomodulating, anti-radiation, calmness, stable, heart tonifying, blood pressure lowering, antitussive, relieving asthma, blood sugar lowering etc.The sporoderm of Ganoderma spore is two-layer, is made up of (polysaccharide wall), and has concentrically ringed layered network chitin and glucosan, strong but pliable in texture, acid and alkali-resistance, extremely difficult oxidation Decomposition, because which limit people's digesting and assimilating active substance in spore.In order to make full use of the active substance in Ganoderma spore, breaking cellular wall must be carried out to spore powder.Domestic and international scientific worker once used the principles such as machinery, biology, chemistry, physics to carry out many-sided discussion to ganoderma lucidium spore powder wall breaking technique, and had achieved higher sporoderm-broken rate.The technology for broken wall of Ganoderma spore powder is broadly divided into 5 classes
[2]: the first kind: bioanalysis.Bacteriolyze method: combining yeast biofermentation and repeatedly boil, Refrigeration Technique, destroy the method for Ganoderma spore powder outer wall; Activate spore: one makes spore be in the state of sprouting, to reach breaking cellular wall and the method for effective component extracting; Enzymatic isolation method: use the low temperature lywallzyme combining ultrasonic crushing technology that dissociates to complete the method for broken wall treatment.Equations of The Second Kind: chemical method.Acid or alkaline degradation: a kind of food acids of PH3 ~ 7 or the edible alkali of pH7 ~ 10 and spore powder produce mixed liquor, the method for breaking cellular wall of then boring a hole with high-voltage pulse; Solvent soaking: reached the method extracting antineoplastic component object by a series of processes such as lixiviate, centrifugal, distillation, column chromatography for separation.3rd class: the technology breaking cellular walls such as Physical, ultrasound wave, microwave dipping, low temperature brittleness.4th class: Mechanical Method.Extrude, roll, comminution by gas stream, shock, the technology such as injection pulverizing.All there is certain defect in above-mentioned technology, such as chemical agent residue at present, length consuming time, and sporoderm-broken rate is uneven, and active ingredient destroys, and the problems such as trivial operations, directly have influence on application and the popularization of ganoderma lucidum wall-broken product.Also result in Ganoderma spore powder with cellular wall broken expensive, ordinary people is difficult to consumption simultaneously.Therefore, be necessary to seek a kind of technology that can overcome above-mentioned defect.
Summary of the invention
The colloid mill that the invention provides a kind of Ganoderma spore powder is pulverized and spraying dry combined wall breakage technology.This technology sporoderm-broken rate is more than 90%, and without chemical reagent, baking temperature is low, and composition heat damage can not be caused to decompose, from breaking cellular wall to dry run, and active ingredient not stripping, without extraneoas loss, pure mechanized operation, the suitable large production of batch production.
The technical solution adopted in the present invention is: Ganoderma spore powder adds 10 times amount purified water, soak 30min, stir into suspension, add in colloid mill, with 20 μm of gap running 30min, 10 μm of gap running 20min, examine under a microscope sporoderm-broken rate more than 90%, mixed liquor is added in spray dryer, with 40 turns/min charging, 65 DEG C of dryings, obtain brown Ganoderma spore powder with cellular wall broken powder.
The invention has the beneficial effects as follows: the Ganoderma spore powder obtaining high sporoderm-broken rate, Myrrha chemical residual, active constituent content is high, and can the large production of batch production, both the quality of Ganoderma spore powder can have been ensured, the breaking cellular wall cost of Ganoderma spore powder can be reduced again, thus Ganoderma spore powder with cellular wall broken product price can be reduced, common people are afforded.Therefore the application of this technology has huge economic benefit and social benefit with popularization.
Accompanying drawing explanation
The process chart of this product of Fig. 1
Detailed description of the invention
Soak: take Ganoderma spore powder 200g, add 2L purified water, soak 30min.
Grind: Ganoderma spore powder is stirred into suspension together with water, join colloid mill JM50 (Shanghai Shen Yin Machinery Co., Ltd.), adjusting play is 20 μm, running 30min, then 10 μm, adjusting play, running 20min.
Percentage of damage measures: dip mixed liquor one with Glass rod and put on microscope slide, and observe with under microscope 10 × 40 times, sporoderm-broken rate should more than 90%.
Spraying dry: open Highspeedcentrifugingandsprayingdrier LPG-5 (Nanjing Nowe drying equipment factory) power supply, heating-up temperature 65 DEG C is set, leaving air temp 45 DEG C, blower fan frequency 2000 turns/min, when temperature to be heated rises to setting value, opens peristaltic pump, setting speed 40 turns/min, charging, after spraying terminates, closes blower fan.Obtain brown powder.
Claims (2)
1. a ganoderma lucidium spore powder wall breaking technology, is characterized by: colloid mill is pulverized and spraying dry associating.
2. the technology of preparing involved by right 1, is characterized by: by soaking, grind, the step such as percentage of damage mensuration, spraying dry and parameter thereof form.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105219647A (en) * | 2015-10-23 | 2016-01-06 | 南京中医药大学 | A kind of wall-breaking method of Ganoderma spore |
CN106727737A (en) * | 2016-12-06 | 2017-05-31 | 陈孝 | Method for shelling ganoderma lucidum spore powder with improved efficacy |
CN110974854A (en) * | 2019-12-04 | 2020-04-10 | 福州东星生物技术有限公司 | Ganoderma spore powder colloid mill grinding and spray drying combined wall breaking process and device thereof |
CN113679033A (en) * | 2020-12-17 | 2021-11-23 | 浙江百山祖生物科技有限公司 | Sterilizing method of ganoderma lucidum spore powder and traditional Chinese medicine decoction pieces or health-care food |
-
2014
- 2014-02-14 CN CN201410055657.8A patent/CN104840492A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105219647A (en) * | 2015-10-23 | 2016-01-06 | 南京中医药大学 | A kind of wall-breaking method of Ganoderma spore |
CN106727737A (en) * | 2016-12-06 | 2017-05-31 | 陈孝 | Method for shelling ganoderma lucidum spore powder with improved efficacy |
CN106727737B (en) * | 2016-12-06 | 2020-09-11 | 陈孝 | Method for shelling ganoderma lucidum spore powder with improved efficacy |
CN106727737B8 (en) * | 2016-12-06 | 2020-10-27 | 陈孝 | Method for shelling ganoderma lucidum spore powder with improved efficacy |
CN110974854A (en) * | 2019-12-04 | 2020-04-10 | 福州东星生物技术有限公司 | Ganoderma spore powder colloid mill grinding and spray drying combined wall breaking process and device thereof |
CN113679033A (en) * | 2020-12-17 | 2021-11-23 | 浙江百山祖生物科技有限公司 | Sterilizing method of ganoderma lucidum spore powder and traditional Chinese medicine decoction pieces or health-care food |
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Application publication date: 20150819 |