CN104840402A - Foam disinfectant hand sanitizer as well as preparation method and application thereof - Google Patents

Abstract

The invention discloses a foam disinfectant hand sanitizer. The foam disinfectant hand sanitizer consists of the following raw materials in parts by weight: 0-150g of polyoxyethylene fatty alcohol sodium sulfate, 0-100g of cocoalkanoylamido propyl betaine, 0-100g of lauryl sodium sulfate, 0-200g of polysorbate-20, 0.5-1g of essence, 1-60g of bamboo charcoal essential oil, 1.0-50ml of a 5-10wt% triclosan ethanol solution and the balance of purified water, wherein the total weight of the raw materials is 1000g. The prepared disinfectant hand sanitizer disclosed by the invention is a disinfectant, adopts the combination of Chinese traditional medicines and western medicines, and integrates quick action and long-term action; and a washing foaming agent is formed by compounding anions, amphoteric ions and non-ionic surfactants, can be used for playing synergistic effects, and is an ecological and environment-friendly disinfectant hand sanitizer with high efficiency, long-term action, no toxicity and no residues.

Description

A kind of foam disinfectant handwashing liquid and Synthesis and applications thereof

Technical field

The invention belongs to light industry field, be specifically related to a kind of foam disinfectant handwashing liquid and preparation method thereof.

Background technology

Hands is position the most frequently, the human contact external world, very easily pollutes various antibacterial, in routine work with life especially in the environment such as hospital that there is a large amount of pathogenic microorganism.Medical worker medical treatment, in nursery work inevitably by microbiological contamination, if do not do hand disinfection work well very easily cause hospital infection.In order to control the generation of nosocomial infection, our country more and more payes attention to Medical personnel hand disinfection, and is emphasizing the work of Medical personnel hand hygienic practice, and this just makes hand-wrist bones product have stable, long-term demand in medical institutions.And in daily life, due to the raising of people's living standard, the understanding of health perception, strick precaution disease also progressively improves, especially experienced by severe acute respiratory syndrome, bird flu, hand-foot-mouth disease, influenza A H1N1, people have had fine understanding to disinfectant application, and hand-wrist bones produce market demand increases.Especially financial work (as bank personnel, sales counter cashier) is engaged in and out on tours personnel sanitize ones hands product consumption increases.Have survey data to show, the bacterial pollution state qualification rate of Bank Clerk personnel counting finger is only 36.25%; After cashier's number banknote 3000, its thumb, middle finger and forefinger and the number that carries disease germs increase by 37 times than before counting.The demand colony of visible disinfectant solution is huge.

The main function of handwashing liquid plays the effect of clean skin protection, and sphere of consumption is public place and house, tourism etc., is the product of " sutable for men, women, and children ".From product attribute, the market prospect of handwashing liquid, it be market clusters long, contain the product enriching market potential.Traditional clean, sterilization are two parts, two steps, use and have inconvenience more.And traditional handwashing liquid minority has the sensation of rushing and not washing clean, more with water, or be easy to rinse the drawbacks such as incomplete.And foam liquid soap due to the foam produced very many, its surface area is very large, can adsorb a lot of dirt, easily except crude removal.So have consumption few, easily the advantage such as to rinse well, progressively become a kind of fashion, be suitable for, green new generation product.

At present, the disinfectant for hand disinfection is of a great variety, its constituent and performance different, common have: povidone iodine, ethanol, isopropyl alcohol, hibitane (hibitane), high redox potential water, chlorine-containing disinfection liquid and other compound disinfectant etc.Although hand disinfectant is of a great variety in the market, but preferred disinfectants is difficult to seek, as above-mentioned disinfectant respectively has pluses and minuses: povidone iodine is each thing of network of iodine and surfactant, overcome iodine and be insoluble in the shortcoming such as water, easily distillation, irritant, stable not, easy coloring.Although but iodophor disinfection is effective, large by organic substance influence, after sterilization, drying time is oversize, has the undesirable sensation that is clamminess.75% ethanol disinfection is quick, but volatile, has larger zest to skin, if carry out handwashing disinfection through conventional ethanol, skin can because defat and drying, coarse; The sterilization of skin degerming especially Medical personnel hand also exists place not fully up to expectations always in a word.

Triclosan is novel chlorin-containing disinfector, suppression and killing action is had to Gram-positive and negative bacterium, especially very high inhibition and killing action is had to Gram-positive, effect compares bromo geramine, the disinfectants such as hibitane are strong, even if there is being serum, it is still effective when blood etc. exist, and consumption is few, pathogenic entero becteria can be killed, pyococcus, saccharomytes, common bacteria in nosocomial infection, mycobacteria, be widely used in hand sterilizing, visual area is prepared, rinse wound, rinsing the mouth antiinflammatory, burn and scald, sterilization of instruments and room, the sterilizations such as furniture, be applicable to medical institutions, bank, catering trade, public place of entertainment, school, the public places such as office, and at home, go on business, tourism uses.Use particularly extensive in cosmetics, toothpaste.For this reason, the present invention is on the basis with reference to interrelated data and the investigation market demand, a large amount of research work has been carried out in hand disinfectant and handwashing liquid, consider the requirements such as sterilization is efficient, safety, stability, practicality, cheap property, convenience, when selecting disinfectant composition, preferred triclosan.

Modern pharmacological research shows, some Chinese herbal medicine extract, and especially Essential Oils has effect that is antibacterial, anticorrosion and mould fungus inhibition, and can remove the little small pox caused by chickenpox and herpes zoster and unclean position, clean-up effect is fabulous.Also have splendid repair function, can repair damaged cell, promote cell regeneration, desalination pox print, pox hole, make skin smooth flawless fast.Current research shows, bamboo charcoal quintessence oil has effect of better antibacterial, anticorrosion and mould fungus inhibition, and lasting medicine is nontoxic, non-stimulated, low price, and has synergistic function with triclosan.

In hand sanitizer formula screening, consider the requirements such as efficiency is high, consumption is few, easily rinse well, determine that current clean result is best, the fastest and with the few up-to-date handwashing liquid dosage form-foam liquid soap of water, and with the highest just surface-active agent sodium lauryl sulphate of bubbling efficiency, cocamidopropyl betaine for main component, consider and the requirement such as the compatibility of antibacterial and the building performance of washing simultaneously, suitably with the addition of some non-ionic surface agent.On this basis, the mutual compatibility between each component of research and compound proportion is continued.Through repeatedly bactericidal effect, the checkings such as clean result, stability test and application experiment, are finally developed into the antibacterial foam liquid soap of efficient sterilizing, integrate cleaning-sterilizing, and sterilization, clean economic benefits and social benefits unification, finally filter out preferably formula for a product.

Summary of the invention

The object of the invention is to the behaviour in service of society and the market demand, disinfectant and handwashing liquid, in foam liquid soap, add the Chinese medicine and western medicine compound recipe composition that some can play sterilization, bactericidal action, a kind of foam disinfectant handwashing liquid and preparation method thereof is provided.This handwashing liquid integrates cleaning-sterilizing, sterilization, clean economic benefits and social benefits unification, remarkably productive.

A kind of foam disinfectant handwashing liquid, be made up of following raw material: polyoxyethylenated alcohol sodium sulfate 10g ~ 150g, cocamido propyl betaine 20 g ~ 100g, sodium lauryl sulphate 10g ~ 100g, Tween-20 0 20g ~ 200g, essence 0.5 g ~ 1g, bamboo charcoal quintessence oil 1 g ~ 60g, 5 wt% ~ 10wt% triclosan alcoholic solution 1.0 ~ 50ml, add pure water to 1000g.

More excellent, described foam disinfectant handwashing liquid, is made up of following raw material: polyoxyethylenated alcohol sodium sulfate 60g, cocamido propyl betaine 50g, sodium lauryl sulphate 60g, Tween-20 40g, essence 0.5g, bamboo charcoal quintessence oil 10g, 10wt% triclosan 10ml, adds pure water 1000g.

Described bamboo charcoal quintessence oil is prepared by the following method: get 10g bamboo tar, add 30-50ml dehydrated alcohol

Abundant stirring and dissolving, filter and remove residue, gets filtrate and evaporates ethanol with Rotary Evaporators and namely obtain bamboo charcoal quintessence oil.

Prepare a method for foam disinfectant handwashing liquid as above, specifically comprise the following steps:

(1) triclosan dissolves in 95% ethanol, and preparation obtains 5 wt% ~ 10wt% triclosan alcoholic solution;

(2) by polyoxyethylenated alcohol sodium sulfate, cocamido propyl betaine, sodium lauryl sulphate, Tween-20 mixing; Add bamboo charcoal quintessence oil, triclosan alcoholic solution and essence more successively, stir entirely molten to transparent, more slowly add pure water while stirring to 1000g.

The application of described foam disinfectant handwashing liquid in preparation or preparation dissipation pathogenic bacterium liquid, wherein said pathogenic bacterium are escherichia coli, Candida albicans, staphylococcus aureus or Pseudomonas aeruginosa.

Feature of the present invention is: formula of the present invention is made up of chemosterilant, plants essential oil, Integrated TCM; Detergent is anion, amphion and non-ionic surface active agent, plays synergistic function, and assistant is with moisturizing and stabilizing agent, efficient, long-acting, nontoxic, is ecological green disinfectant handwashing liquid.

Beneficial effect of the present invention is:

(1) bacteriostasis and sterilization composition of the present invention is by Integrated TCM, quick-acting and long-acting combination, and drug effect is fast, and lastingly, nontoxic, noresidue is ecological ideas preparation; Foam shampoo is anion, amphion and non-ionic surface active agent compound, and consumption is few, foam is many, and cleaning effect is good;

(2) production technology of the present invention is simple, and reduced investment, easy to operate, cost is low, is easy to realize industrialization.Novel foam disinfection hand cleanser of the present invention is used for hand disinfection, reaches 100% in 0.5min to killing rates such as escherichia coli, Candida albicans, staphylococcus aureus, Pseudomonas aeruginosas.

Detailed description of the invention

The present invention's the following example further illustrates the present invention, but protection scope of the present invention is not limited to the following example.

embodiment 1

Polyoxyethylenated alcohol sodium sulfate 60g, cocamido propyl betaine 50g, sodium lauryl sulphate 60g, Tween-20 40g, essence 0.5g, bamboo charcoal quintessence oil 10g, 10% triclosan 10ml, adds pure water 1000g.

Preparation method is:

(1) 10% triclosan: 10g triclosan dissolves in 100ml 95% ethanol and get final product.

(2) by polyoxyethylenated alcohol sodium sulfate, cocamido propyl betaine, sodium lauryl sulphate, Tween-20 mixing; Add bamboo charcoal quintessence oil, 10% triclosan and essence more successively, stir entirely molten to transparent, more slowly add pure water while stirring to 1000g.

embodiment 2

Polyoxyethylenated alcohol sodium sulfate 55g, cocamido propyl betaine 40g, sodium lauryl sulphate 65g, Tween-20 30g, essence 0.5g, bamboo charcoal quintessence oil 20g, 10% triclosan 5ml, adds pure water 1000g.

Preparation method is:

(1) 10% triclosan: 10g triclosan dissolves in 100ml 95% ethanol and get final product.

(2) by polyoxyethylenated alcohol sodium sulfate, cocamido propyl betaine, sodium lauryl sulphate, Tween-20, mixing; Add bamboo charcoal quintessence oil, 10% triclosan and essence more successively, stir entirely molten to transparent, more slowly add pure water while stirring to 1000g.

embodiment 3

Polyoxyethylenated alcohol sodium sulfate 65g, cocamido propyl betaine 50g, sodium lauryl sulphate 65g, Tween-20 20g, essence 0.5g, bamboo charcoal quintessence oil 30g, 5% triclosan 5ml, adds pure water 1000g.

Preparation method is:

(1) 5% triclosan: 5g triclosan dissolves in 100ml 95% ethanol and get final product.

(2) by polyoxyethylenated alcohol sodium sulfate, cocamido propyl betaine, sodium lauryl sulphate, Tween-20, mixing; Add bamboo charcoal quintessence oil, 10% triclosan and essence more successively, stir entirely molten to transparent, more slowly add pure water while stirring to 1000g.

embodiment 4

Polyoxyethylenated alcohol sodium sulfate 60g, cocamido propyl betaine 50g, sodium lauryl sulphate 60g, Tween-20 40g, essence 0.5g, bamboo charcoal quintessence oil 50g, 5% triclosan 6ml, adds pure water 1000g.

Preparation method is:

(1) 5% triclosan: 5g triclosan dissolves in 100ml 95% ethanol and get final product.

(2) by polyoxyethylenated alcohol sodium sulfate, cocamido propyl betaine, sodium lauryl sulphate, Tween-20, mixing;

(3) in above-mentioned mixed liquor, add bamboo charcoal quintessence oil, 5% triclosan and essence successively, stir entirely molten to transparent, more slowly add pure water while stirring to 1000g.

embodiment 5

Polyoxyethylenated alcohol sodium sulfate 60g, cocamido propyl betaine 50g, sodium lauryl sulphate 60g, Tween-20 20g, bamboo charcoal quintessence oil 5g, essence 0.5g, 10% triclosan 20ml, adds pure water 1000g.

Preparation method is:

(1) 10% triclosan: 10g triclosan dissolves in 100ml 5% triclosan and get final product.

(2) by polyoxyethylenated alcohol sodium sulfate, cocamido propyl betaine, sodium lauryl sulphate, Tween-20, mixing; Add bamboo charcoal quintessence oil, 10% triclosan and essence more successively, be stirred to transparent, more slowly add pure water while stirring to 1000g.

This product stock solution is to escherichia coli, golden yellow Staphylococcus aureus, Pseudomonas aeruginosa in laboratory conditions, effect 0.5min, 1.0min, 1.5min, and kill oncomelania is all greater than 5.0; To Candida albicans, effect 0.5min, 1.0min, 1.5min, average kill oncomelania is greater than 4.0; And human body hands on-site disinfection test, to 30 person-times of 1min that sterilize with skin natural bacteria on hand, average kill oncomelania is greater than 1.0.

Preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.

Claims (5)

1. a foam disinfectant handwashing liquid, it is characterized in that: be made up of following raw material: polyoxyethylenated alcohol sodium sulfate 10g ~ 150g, cocamido propyl betaine 20 g ~ 100g, sodium lauryl sulphate 10g ~ 100g, Tween-20 0 20g ~ 200g, essence 0.5 g ~ 1g, bamboo charcoal quintessence oil 1 g ~ 60g, 5 wt% ~ 10wt% triclosan alcoholic solution 1.0 ~ 50ml, add pure water to 1000g.

2. foam disinfectant handwashing liquid according to claim 1, it is characterized in that: be made up of following raw material: polyoxyethylenated alcohol sodium sulfate 60g, cocamido propyl betaine 50g, sodium lauryl sulphate 60g, Tween-20 40g, essence 0.5g, bamboo charcoal quintessence oil 10g, 10wt% triclosan 10ml, adds pure water 1000g.

3. prepare a method for foam disinfectant handwashing liquid as claimed in claim 1, it is characterized in that: specifically comprise the following steps:

(1) triclosan dissolves in 95% ethanol, and preparation obtains 5 wt% ~ 10wt% triclosan alcoholic solution;

(2) by polyoxyethylenated alcohol sodium sulfate, cocamido propyl betaine, sodium lauryl sulphate, Tween-20 mixing; Add bamboo charcoal quintessence oil, triclosan alcoholic solution and essence more successively, stir entirely molten to transparent, more slowly add pure water while stirring to 1000g.

4. the application of the foam disinfectant handwashing liquid as described in claim 1-2 any one in preparation or preparation dissipation pathogenic bacterium liquid.

5. application according to claim 4, is characterized in that: described pathogenic bacterium are escherichia coli, Candida albicans, staphylococcus aureus or Pseudomonas aeruginosa.