CN104800762A - Traditional Chinese medicine composition for treating dysmenorrhea - Google Patents
Traditional Chinese medicine composition for treating dysmenorrhea Download PDFInfo
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- CN104800762A CN104800762A CN201510219546.0A CN201510219546A CN104800762A CN 104800762 A CN104800762 A CN 104800762A CN 201510219546 A CN201510219546 A CN 201510219546A CN 104800762 A CN104800762 A CN 104800762A
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Abstract
The invention provides a traditional Chinese medicine composition for treating dysmenorrheal. The traditional Chinese medicine composition is prepared from the following raw materials: piper wallichii, duchesnea indica, cuscuta australis, cortex moutan, cornu cervi degelatinatum and the like. The traditional Chinese medicine composition can be used for treating dysmenorrhea.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and the preparation method and application that are used for the treatment of dysmenorrhea.
Background technology
Dysmenorrhea in love will of falling ill hindered, daily life accidentally or six climate exopathogens the different pathogeny such as to cause harm, and relevant with physiological status special before and after ferritic and menstrual period, menstrual period.Pathomechanism is that above-mentioned factor causes punching to appoint addiction resistance, and QI-blood circulation is not smooth, and the circulation of uterus menses is obstructed, so that " stagnation of QI and blood may bring about pain ", or caused by liver and kidney deficiency, deficient qi and blood, so that " not Rong Ze pain ".For the treatment of primary disease, Western medicine is without specific drug.Clinical treatment mainly applies calmness, analgesia, solution spasm Drug therapy to the ill.Application prostate synthetase inhibitors, by suppressing prostate synzyme, prevented strong or spastic uterine contraction, as ibuprofen, ketoprofen, fenamic acids etc., but cure the symptoms, not the disease, and not controlling dysmenorrhea, when causing women's hurt like hell of many dysmenorrheas, intramuscular injection croak is for surely waiting anaesthetic, has a strong impact on healthy.The traditional Chinese medical science is to the treatment of primary disease, tired for the rule for the treatment of to regulate the flow of vital energy, to invigorate blood circulation, to change, but lacks real effective patent medicine in the market.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that are used for the treatment of dysmenorrhea.
Technical scheme: the object of the invention is by following scheme realize:
Be used for the treatment of a Chinese medicine composition for dysmenorrhea, it is prepared by the crude drug of following parts by weight: Caulis et Folium piperis 15 parts, Herba potentillae kleinianae 10 parts, Semen Cuscutae 20 parts, Cortex Moutan 10 parts, Cornu Cervi Degelatinatum 10 parts, Oletum Trogopterori 10 parts, the Radix Linderae 6 parts, Bulbus Fritillariae Uninbracteatae 10 parts, Semen Platycladi 20 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Corydalis 10 parts, the Radix Paeoniae Alba 10 parts, Cortex Cinnamomi 6 parts, Herba Leonuri 10 parts, the Rhizoma Pinelliae 10 parts, Radix Angelicae Sinensis 10 parts, Radix Paeoniae Rubra 10 parts, Rhizoma Cyperi 10 parts, 10 parts, Rhizoma Curcumae Longae, Fructus Foeniculi 6 parts, Radix Asteris 10 parts.
The described Chinese medicine composition being used for the treatment of dysmenorrhea, described Chinese medicine composition adds adjuvant, makes oral liquid, tablet, capsule or granule with the formulation method of routine.
The described Chinese medicine composition being used for the treatment of dysmenorrhea, described adjuvant be dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose, stevioside one or more.
The described Chinese medicine composition being used for the treatment of dysmenorrhea, preparation method comprises the steps: material merging of getting it filled, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, is added water by concentrated solution and auxiliaries becomes oral liquid, or by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
The described preparation method being used for the treatment of the Chinese medicine composition of dysmenorrhea, in preparation method, spray drying condition is: inlet temperature is 80-120 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
The application of the above-mentioned Chinese medicine composition being used for the treatment of dysmenorrhea in preparation treatment dysmenorrhea medicine.
In the present invention, Caulis et Folium piperis is Piperaceae Piper plant Caulis et Folium piperis Piperwallichii (Miq.) Hand.-Mazz.varhupehense (DC.) Hand.-mazz., is used as medicine with stem, leaf or Herb.Herb can be adopted the whole year.Stem, Ye Xiaqiu gather, and dry respectively.Wind-damp dispelling, strong waist knee joint, pain relieving, cough-relieving.For rheumatic arthralgia, bruise, weakness of the waist and knees, dysmenorrhea, anemofrigid cold, cough and asthma.The present invention is used as medicine with Herb.
Herba potentillae kleinianae is Rosaceae potentilla plants.Classification system Potentilla kleiniana Wight et Arn., toil, cool.Heat clearing away, removing toxic substances.Control the high heat of infantile convulsion, malaria, cough, laryngalgia, arthralgia chiefly caused by damp pathogen, carbuncle tinea skin ulcer, erysipelas, prurigo, Serpentis, insect bite wound.The present invention is with all herbal medicine.All the other raw materials are pharmacopeia kind.
Beneficial effect:
From theory of Chinese medical science, in we, Caulis et Folium piperis, Herba potentillae kleinianae, Semen Cuscutae, Cortex Moutan, Cornu Cervi Degelatinatum, Oletum Trogopterori, Radix Linderae blood circulation promoting and blood stasis dispelling are monarch drug, Bulbus Fritillariae Uninbracteatae, Semen Platycladi, Radix Salviae Miltiorrhizae, Rhizoma Corydalis, the Radix Paeoniae Alba, Cortex Cinnamomi, Herba Leonuri, the Rhizoma Pinelliae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Cyperi are regulated the flow of vital energy, stimulate the menstrual flow, pain relieving is minister, Rhizoma Curcumae Longae, Fructus Foeniculi, Radix Asteris etc. are adjuvant, all medicines are harmonious, play blood circulation promoting and blood stasis dispelling altogether, regulate the flow of vital energy, analgesic effect, be used for the treatment of dysmenorrhea.Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, and determined curative effect.The present invention consists of Chinese crude drug, has no side effect, low price.High for dysmenorrhea sickness rate, the features such as easy recurrence, the present invention, once listing, will produce huge economic benefit and social benefit.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, embodiment is prepared
Embodiment 1: get Caulis et Folium piperis 15g, Herba potentillae kleinianae 10g, Semen Cuscutae 20g, Cortex Moutan 10g, Cornu Cervi Degelatinatum 10g, Oletum Trogopterori 10g, Radix Linderae 6g, Bulbus Fritillariae Uninbracteatae 10g, Semen Platycladi 20g, Radix Salviae Miltiorrhizae 10g, Rhizoma Corydalis 10g, Radix Paeoniae Alba 10g, Cortex Cinnamomi 6g, Herba Leonuri 10g, Rhizoma Pinelliae 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 10g, Rhizoma Cyperi 10g, Rhizoma Curcumae Longae 10g, Fructus Foeniculi 6g, Radix Asteris 10g medical material merges, and decocts with water twice, and first time adds water as 10 times amount of medical material weight, decocts 1.5h, and second time adds water as 8 times amount of medical material weight, decocts 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adds 95% (v/v) ethanol and makes alcohol content reach 75% (v/v), stirs, and leaves standstill 24 hours, and decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure becomes to relative density when 65 DEG C is 1.25, and (condition is inlet temperature is 100 DEG C to spraying dry, and leaving air temp is 80 DEG C, and temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), add starch 50g, dry granulation, cross 60 mesh sieves, load No. 1 capsule capsule.
Embodiment 2: get Caulis et Folium piperis 15g, Herba potentillae kleinianae 10g, Semen Cuscutae 20g, Cortex Moutan 10g, Cornu Cervi Degelatinatum 10g, Oletum Trogopterori 10g, Radix Linderae 6g, Bulbus Fritillariae Uninbracteatae 10g, Semen Platycladi 20g, Radix Salviae Miltiorrhizae 10g, Rhizoma Corydalis 10g, Radix Paeoniae Alba 10g, Cortex Cinnamomi 6g, Herba Leonuri 10g, Rhizoma Pinelliae 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 10g, Rhizoma Cyperi 10g, Rhizoma Curcumae Longae 10g, Fructus Foeniculi 6g, Radix Asteris 10g medical material merges, and decocts with water twice, and first time adds water as 12 times amount of medical material weight, decocts 2h, and second time adds water as 10 times amount of medical material weight, decocts 2h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.20, adds 95% (v/v) ethanol and makes alcohol content reach 85% (v/v), stirs, and leaves standstill 24 hours, and decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure becomes to relative density when 65 DEG C is 1.30, and (condition is inlet temperature is 120 DEG C to spraying dry, and leaving air temp is 100 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.), add dextrin 50g, mix homogeneously, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 30 mesh sieves and granulate, in 70 ~ 80 DEG C of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, obtains tablet.
Embodiment 3: get Caulis et Folium piperis 15g, Herba potentillae kleinianae 10g, Semen Cuscutae 20g, Cortex Moutan 10g, Cornu Cervi Degelatinatum 10g, Oletum Trogopterori 10g, Radix Linderae 6g, Bulbus Fritillariae Uninbracteatae 10g, Semen Platycladi 20g, Radix Salviae Miltiorrhizae 10g, Rhizoma Corydalis 10g, Radix Paeoniae Alba 10g, Cortex Cinnamomi 6g, Herba Leonuri 10g, Rhizoma Pinelliae 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 10g, Rhizoma Cyperi 10g, Rhizoma Curcumae Longae 10g, Fructus Foeniculi 6g, Radix Asteris 10g medical material merges, and decocts with water twice, and first time adds water as 10 times amount of medical material weight, decocts 1.5h, and second time adds water as 8 times amount of medical material weight, decocts 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adds 95% (v/v) ethanol and makes alcohol content reach 75% (v/v), stirs, and leaves standstill 24 hours, and decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure becomes to relative density when 65 DEG C is 1.25, and vacuum drying, adds above-mentioned Benexate Hydrochloride, pulverizes, add dextrin 50g again, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 14 mesh sieves and granulate, 70-80 DEG C of drying, 60 order granulate, obtain granule.
2. the clinical observation on the therapeutic effect experiment of traditional Chinese medicine composition for treating dysmenorrhea patient of the present invention
2.1 physical data: adopting Chinese medicine composition of the present invention to treat 100 examples altogether, is women entirely, the oldest person 48 years old, age reckling 16 years old.According to menstrual phase lower abdomen pendant pain, the no positive sign of gynecologial examination, clinical namely diagnosable.The secondary dysmenorrhea that need cause with endometriosis, adenomyosis of uterus, pelvic inflammatory disease is differentiated mutually.
2.2 Therapeutic Method: usage and dosage: adopt the granule prepared by the embodiment of the present invention 3, its usage and consumption are each 1 bag, every bag gram, and every day 3 times, warm water takes, and one month are a course for the treatment of, treat for 3 courses for the treatment of altogether.
2.3 the standard of curative effect evaluation
Cure: sign and symptom are improved completely, happy, in high spirits.Effective: sign and symptom are significantly improved, happy, spirit very well.Effective: sign and symptom change, suddenly feel slightly little suitable, but can accept.Invalid: sign is without change, and symptom is as front.
2.4 therapeutic outcome
In accepted for medical treatment 100 routine cases, through treatment in 4 months, wherein cure 45 examples, effective 24 examples, effective 26 examples, invalid 8 examples, total effective rate reaches 92%.Result shows, Chinese medicine composition of the present invention has extremely significant effect to treatment dysmenorrhea patient.
Claims (6)
1. one kind is used for the treatment of the Chinese medicine composition of dysmenorrhea, it is characterized in that, it is prepared by the crude drug of following parts by weight: Caulis et Folium piperis 15 parts, Herba potentillae kleinianae 10 parts, Semen Cuscutae 20 parts, Cortex Moutan 10 parts, Cornu Cervi Degelatinatum 10 parts, Oletum Trogopterori 10 parts, the Radix Linderae 6 parts, Bulbus Fritillariae Uninbracteatae 10 parts, Semen Platycladi 20 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Corydalis 10 parts, the Radix Paeoniae Alba 10 parts, Cortex Cinnamomi 6 parts, Herba Leonuri 10 parts, the Rhizoma Pinelliae 10 parts, Radix Angelicae Sinensis 10 parts, Radix Paeoniae Rubra 10 parts, Rhizoma Cyperi 10 parts, 10 parts, Rhizoma Curcumae Longae, Fructus Foeniculi 6 parts, Radix Asteris 10 parts.
2. the Chinese medicine composition being used for the treatment of dysmenorrhea according to claim 1, is characterized in that, described Chinese medicine composition adds adjuvant, makes oral liquid, tablet, capsule or granule with the formulation method of routine.
3. the Chinese medicine composition being used for the treatment of dysmenorrhea according to claim 1, it is characterized in that, described adjuvant be dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose, stevioside one or more.
4. the Chinese medicine composition being used for the treatment of dysmenorrhea according to claim 1, it is characterized in that, preparation method comprises the steps: material merging of getting it filled, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution to be added water and auxiliaries becomes oral liquid, or by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
5. the preparation method being used for the treatment of the Chinese medicine composition of dysmenorrhea according to claim 1, it is characterized in that, in preparation method, spray drying condition is: inlet temperature is 80-120 DEG C, leaving air temp is 80-90 DEG C, temperature of charge is 70-90 DEG C, atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
6. the application of Chinese medicine composition in treatment dysmenorrhea medicine being used for the treatment of dysmenorrhea according to claim 1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012636A (en) * | 2015-08-07 | 2015-11-04 | 李强 | Traditional Chinese medicine composition for treating dysmenorrhea |
| CN105534151A (en) * | 2015-12-28 | 2016-05-04 | 吴华娟 | Traditional Chinese medicinal seat cushion for treating dysmenorrhea |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293894A (en) * | 2011-07-18 | 2011-12-28 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating dysmenorrhea, and preparation method and application thereof |
| CN103989893A (en) * | 2014-06-16 | 2014-08-20 | 徐艳 | Traditional Chinese medicinal composition for treating dysmenorrhea, as well as preparation method and application thereof |
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2015
- 2015-05-02 CN CN201510219546.0A patent/CN104800762A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293894A (en) * | 2011-07-18 | 2011-12-28 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating dysmenorrhea, and preparation method and application thereof |
| CN103989893A (en) * | 2014-06-16 | 2014-08-20 | 徐艳 | Traditional Chinese medicinal composition for treating dysmenorrhea, as well as preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012636A (en) * | 2015-08-07 | 2015-11-04 | 李强 | Traditional Chinese medicine composition for treating dysmenorrhea |
| CN105534151A (en) * | 2015-12-28 | 2016-05-04 | 吴华娟 | Traditional Chinese medicinal seat cushion for treating dysmenorrhea |
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Application publication date: 20150729 |