CN104800358B - A kind of bitter eucalyptus is dispelled rash foaming agent and preparation method thereof - Google Patents
A kind of bitter eucalyptus is dispelled rash foaming agent and preparation method thereof Download PDFInfo
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- CN104800358B CN104800358B CN201510136504.0A CN201510136504A CN104800358B CN 104800358 B CN104800358 B CN 104800358B CN 201510136504 A CN201510136504 A CN 201510136504A CN 104800358 B CN104800358 B CN 104800358B
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Abstract
Dispelled rash foaming agent and preparation method thereof the invention discloses a kind of bitter eucalyptus, it is made up of active pharmaceutical ingredient, foam matrix and water, its active pharmaceutical ingredient is made up of golden cypress, frutus cnidii, kuh-seng, the fruit of summer cypress, CORTEX AILANTHI, Pogostemon cablin, eucalyptus robusta of water extraction or alcohol extracting；Foam matrix is by lauryl sodium sulfate, polyoxyethylene sorbitan monoleate, glycerine.The present invention has excellent antibacterial, anti-inflammatory, antipruritic, rash of dispelling effect, and foaming agent has greater advantage to treatment skin extensive inflammation, and the present invention need not add propellant, hand pressure foam-making apparatus can directly be used, not only pollution can be also reduced with cost-effective, at the same it is also safer.
Description
Technical field
The present invention relates to a kind of foaming agent and its process for making, dispelled rash foaming agent and its preparation more particularly to bitter eucalyptus
Method.
Background technology
Foaming agent is usually that bulk drug or the extracted rear plus appropriate amount of auxiliary materials of Chinese medicine are configured to decoction, then pours into pressure vessel
Inside it is filled with propellant or directly pours into foam pump bottle and be made.
Foaming agent is different from ointment, emulsifiable paste or lotion, has greater advantage to treatment skin extensive inflammation.But existing bubble
Foam agent is both needed to add propellant (dicholorodifluoromethane), and foam is produced by the effect of dicholorodifluoromethane.Due to dichloro two
Fluoromethane is pernicious gas, easily causes environmental pollution, while pressure vessel is again explosive and reduce its security.
Traditional Chinese medicine Topical therapy treatment skin disease is of long standing and well established, and curative effect is reliable, in thousands of years of development, have accumulated a large amount of
Recipe name medicine.Clinic shows that Chinese medicine has the incomparable advantage of many Western medicine, as indication is wide, few side effects, drug resistance
Low, comprehensive drug protrudes.
The content of the invention
Dispelled rash foaming agent it is an object of the invention to provide a kind of bitter eucalyptus for treating disease of skin.
Dispelled it is a further object to provide above-mentioned bitter eucalyptus the preparation method of rash foaming agent.
The technical solution adopted in the present invention is：A kind of bitter eucalyptus is dispelled rash foaming agent, by active pharmaceutical ingredient, foam matrix and
Water forms, it is characterised in that：Described active pharmaceutical ingredient is made up of the Chinese medicine of following parts by weight：Golden cypress 50-70 parts, cnidium monnieri
Sub- 70-90 parts, kuh-seng 50-70 parts, fruit of summer cypress 50-70 parts, CORTEX AILANTHI 50-70 parts, Pogostemon cablin 35-45 parts, eucalyptus robusta 70-90
Part；Described foam matrix composition is the component of following parts by weight：5-15 parts lauryl sodium sulfate, the poly- sorb of 10-20 parts
Ester 80,50-150 part glycerine.
Described active pharmaceutical ingredient is made up of the Chinese medicine of following parts by weight：60 parts of golden cypress, 80 parts of frutus cnidii, kuh-seng 60
Part, 60 parts of the fruit of summer cypress, 60 parts of CORTEX AILANTHI, 40 parts of Pogostemon cablin, 80 parts of eucalyptus robusta.
Above-mentioned bitter eucalyptus is dispelled the preparation method of rash foaming agent, it is characterised in that is comprised the following steps：
(1) take kuh-seng, the fruit of summer cypress, bark of tree of heaven to add 10-14 times to measure water by formula, water extraction 2 times, filtration, merging filtrate, be concentrated to
Equivalent to 0.9-1.1 grams crude drug of every milliliter of decoction, obtains A liquid；
(2) take golden cypress, frutus cnidii to add 7-9 times to measure 50-85% ethanol by formula, extract 2 times, filtration, merging filtrate, concentration
To equivalent to 0.9-1.1 grams crude drug of every milliliter of decoction, B liquid is obtained；
(3) take Pogostemon cablin, eucalyptus robusta to add 10-14 times to measure water by formula, extract to obtain volatile oil, be C liquid；
(4) A, B, C liquid are mixed, adds lauryl sodium sulfate, polyoxyethylene sorbitan monoleate, glycerine by formula, stir, then
Add water to stir, obtain D liquid, the concentration of lauryl sodium sulfate is 5-15g/1000ml in D liquid；
5) D liquid is poured into hand pressure foam pump bottle, screwed, obtain finished product.
In described step (1), take kuh-seng, the fruit of summer cypress, bark of tree of heaven to add 10-14 times to measure water by formula, soak 20-40 minutes,
Extraction 2 times, each 1.5-2.5 hours.
In the step (2), take golden cypress, frutus cnidii to add 7-9 times to measure 75% ethanol by formula, extract 2 times, each 1-2 is small
When.
In the step (3), take Pogostemon cablin, eucalyptus robusta to add 10-14 times to measure water by formula, soak 1-2 hours, extract 4-6
Hour, extract to obtain volatile oil.
The present invention has excellent antibacterial, anti-inflammatory, antipruritic, rash of dispelling effect, and, general different from ointment, emulsifiable paste or lotion
Drug distribution wears shear force in negligible machinery on skin, and this has greater advantage to treatment skin extensive inflammation, is used for moreover, working as
Such a preparation lather collapse is fast during more hair-fields such as hair, easily enters cuticula by hair shaft.The present invention is cast without adding
Agent, hand pressure foam-making apparatus can be directly used, can also not only reduced due to adding propellant and cause with cost-effective
Environmental pollution, while also reduce the explosive danger of pressure vessel, be allowed to safer.
Embodiment
The present invention is that a kind of bitter eucalyptus is dispelled rash foaming agent, is made up of active pharmaceutical ingredient, foam matrix and water.
Active pharmaceutical ingredient primarily serves antibacterial, anti-inflammatory, antipruritic, rash of dispelling effect, by the Chinese medicine system of following parts by weight
Into：Golden cypress 50-70 parts, frutus cnidii 70-90 parts, kuh-seng 50-70 parts, fruit of summer cypress 50-70 parts, CORTEX AILANTHI 50-70 parts, Pogostemon cablin
35-45 parts, eucalyptus robusta 70-90 parts.Foam matrix composition is the component of following parts by weight：5-15 part lauryl sodium sulfate
(as foaming agent), 10-20 parts polyoxyethylene sorbitan monoleate (as solubilizer), 50-150 parts glycerine (as thickener).Preferably, by
The Chinese medicine of following parts by weight is made：It is 60 parts of golden cypress, 80 parts of frutus cnidii, 60 parts of kuh-seng, 60 parts of the fruit of summer cypress, 60 parts of CORTEX AILANTHI, wide
40 parts of wrinkled giant hyssop, 80 parts of eucalyptus robusta.
In the present invention, kuh-seng is legume kuh-seng Sophora flavescens Ait. dry root.The fruit of summer cypress is lamb's-quarters
Section plant summer cypress Kochia scoparia (L.) Schrad. dry mature fruit.CORTEX AILANTHI is quassia tree-of-heaven
Ailanthusaltissima (Mill.) Swingle dry root skin or dry hide.Golden cypress is rutaceae wampee
(Phellodendron chinense Schneid.) or cork tree (Phellodendron amurense Rupr.) dry tree
Skin.Frutus cnidii is samphire cnidium monnieri Cnidium monnieri (L) cuss. dry mature fruit.Pogostemon cablin is lip
Section plant Pogostemon cablin Pogostemon cablin (Blanco) Benth. dry aerial parts.Eucalyptus robusta is planted for Myrtaceae
Thing eucalyptus robusta Eucalyptus robusta Simth dried leaf.
Above-mentioned bitter eucalyptus is dispelled the preparation method of rash foaming agent, is comprised the following steps：
(1) take kuh-seng, the fruit of summer cypress, bark of tree of heaven to add 10-14 times to measure water by formula, water extraction 2 times, filtration, merging filtrate, be concentrated to
Equivalent to 0.9-1.1 grams crude drug of every milliliter of decoction, obtains A liquid.Preferably, kuh-seng, the fruit of summer cypress, bark of tree of heaven is taken to add 10-14 by formula
Amount water again, 20-40 minutes are soaked, extracted 2 times, each 1.5-2.5 hours.
(2) take golden cypress, frutus cnidii to add 7-9 times to measure 50-85% ethanol by formula, extract 2 times, filtration, merging filtrate, concentration
To equivalent to 0.9-1.1 grams crude drug of every milliliter of decoction, B liquid is obtained.Preferably, golden cypress, frutus cnidii is taken to add 7-9 times to measure by formula
75% ethanol, extract 2 times, each 1-2 hours.
(3) take Pogostemon cablin, eucalyptus robusta to add 10-14 times to measure water by formula, extract to obtain volatile oil, be C liquid.Preferably, by with
Side takes Pogostemon cablin, eucalyptus robusta to add 10-14 times to measure water, soaks 1-2 hours, extracts 4-6 hours, extracts to obtain volatile oil.
(4) A, B, C liquid are mixed, adds lauryl sodium sulfate, polyoxyethylene sorbitan monoleate, glycerine by formula, stir, then
Add distilled water to stir (as solvent), obtain D liquid, the concentration of lauryl sodium sulfate is 5-15g/1000ml in D liquid；
5) D liquid is poured into hand pressure foam pump bottle, screwed, obtain finished product.
With reference to specific example, the present invention is further described, but the present invention is not limited thereto specific examples.
Embodiment 1
The taste of the above 7, take kuh-seng, the fruit of summer cypress, bark of tree of heaven to add 12 times of amount water, soak 30 minutes, extraction 2 times, 2.0 hours every time,
Filtration, merging filtrate, is concentrated to equivalent to 1 gram crude drug of every milliliter of decoction, standby；Golden cypress, frutus cnidii is taken to add 8 times of 75% second of amount
Alcohol, extract 2 times, extract 1.5h every time, reclaim ethanol, filtration, merging filtrate is concentrated to 1: 1, standby；Take Pogostemon cablin, eucalyptus robusta
Add 12 times of amount water, soak 1.5h, extract 5 hours, obtain volatile oil.Above-mentioned Aqueous extracts, alcohol extract, volatile oil are taken, is mixed, adds ten
Sodium dialkyl sulfate, polyoxyethylene sorbitan monoleate, glycerine, stir, and add distilled water to 1000ml and stir, pour into foam
In pump bottle, screw, produce.
Bacteriostatic experiment is carried out to the products obtained therefrom of embodiment 1, found to staphylococcus aureus, MRSE, green pus
Bacillus, Malassezia furfur, Candida albicans have obvious bacteriostasis, insensitive to Escherichia coli and proteus；Enter action
Thing experiment finds that the cavy ear epidermis caused by can mitigating dinitrofluorobenzene-acetone soln thickens and mitigated the leaching of corium inflammatory cell
Profit, cause cavy contact dermatitis-Eczema Model to have an obvious therapeutic action to dinitrofluorobenzene-acetone soln, therapeutic effect with
Compound Dexamethasone Acetate approaches.
Embodiment 2
The taste of the above 7, take kuh-seng, the fruit of summer cypress, bark of tree of heaven to add 10 times of amount water, soak 30 minutes, extraction 2 times, 2.0 hours every time,
Filtration, merging filtrate, is concentrated to equivalent to 1.1 grams crude drugs of every milliliter of decoction, standby；Golden cypress, frutus cnidii is taken to add 7 times of amounts 75%
Ethanol, extract 2 times, extract 1.5h every time, reclaim ethanol, filtration, merging filtrate is concentrated to 1: 1, standby；Take Pogostemon cablin, great Ye
Eucalyptus adds 10 times of amount water, soaks 1.5h, extracts 5 hours, obtain volatile oil.Above-mentioned Aqueous extracts, alcohol extract, volatile oil are taken, is mixed, is added
Lauryl sodium sulfate, polyoxyethylene sorbitan monoleate, glycerine, stir, and add distilled water to 800ml and stir, and pour into bubble
In foam pump bottle, screw, produce.
Embodiment 3
Preparation method is the same as embodiment 1.
Embodiment 4
Preparation method is the same as embodiment 1.
Embodiment 5
Preparation method is the same as embodiment 1.
Claims (6)
- The rash foaming agent 1. a kind of bitter eucalyptus is dispelled, is made up of active pharmaceutical ingredient, foam matrix and water, it is characterised in that：Described work Property drug ingedient is made up of the Chinese medicine of following parts by weight：Golden cypress 50-70 parts, frutus cnidii 70-90 parts, kuh-seng 50-70 parts, summer cypress Sub- 50-70 parts, CORTEX AILANTHI 50-70 parts, Pogostemon cablin 35-45 parts, eucalyptus robusta 70-90 parts, wherein taking kuh-seng, the fruit of summer cypress, Chinese toon root Skin adds 10-14 times to measure water, water extraction 2 times, filtration, merging filtrate, is concentrated to equivalent to 0.9-1.1 grams crude drug of every milliliter of decoction, A liquid is obtained, takes golden cypress, frutus cnidii to add 7-9 times to measure 50-85% ethanol, extracts 2 times, filtration, merging filtrate, be concentrated to every milliliter of decoction Equivalent to 0.9-1.1 grams crude drug, obtains B liquid, takes Pogostemon cablin, eucalyptus robusta to add 10-14 times to measure water, extracts to obtain volatile oil, is C liquid； Described foam matrix composition is the component of following parts by weight：5-15 parts lauryl sodium sulfate, 10-20 part polysorbates 80th, 50-150 parts glycerine, A, B, C liquid are mixed, adds foam matrix, stir, add water and stir, obtain D liquid, D The concentration of lauryl sodium sulfate is 5-15g/1000ml in liquid, and D liquid is poured into hand pressure foam pump bottle, screws, obtains finished product.
- The rash foaming agent 2. bitter eucalyptus according to claim 1 is dispelled, it is characterised in that：Described active pharmaceutical ingredient is by following heavy The Chinese medicine of amount number is made：60 parts of golden cypress, 80 parts of frutus cnidii, 60 parts of kuh-seng, 60 parts of the fruit of summer cypress, 60 parts of CORTEX AILANTHI, Pogostemon cablin 40 Part, 80 parts of eucalyptus robusta.
- The preparation method of rash foaming agent 3. the bitter eucalyptus described in claim 1 or 2 is dispelled, it is characterised in that comprise the following steps：（1）Take kuh-seng, the fruit of summer cypress, CORTEX AILANTHI to add 10-14 times to measure water by formula, water extraction 2 times, filtration, merging filtrate, be concentrated to every Milliliter equivalent to 0.9-1.1 grams crude drug of decoction, obtains A liquid；（2）Take golden cypress, frutus cnidii to add 7-9 times to measure 50-85% ethanol by formula, extract 2 times, filtration, merging filtrate, be concentrated to every Milliliter equivalent to 0.9-1.1 grams crude drug of decoction, obtains B liquid；（3）Take Pogostemon cablin, eucalyptus robusta to add 10-14 times to measure water by formula, extract to obtain volatile oil, be C liquid；（4）A, B, C liquid are mixed, lauryl sodium sulfate, polyoxyethylene sorbitan monoleate, glycerine is added by formula, stirs, add Water stirs, and obtains D liquid, and the concentration of lauryl sodium sulfate is 5-15g/1000ml in D liquid；（5）D liquid is poured into hand pressure foam pump bottle, screws, obtains finished product.
- The preparation method of rash foaming agent 4. bitter eucalyptus according to claim 3 is dispelled, it is characterised in that：Described step（1）In, Take kuh-seng, the fruit of summer cypress, CORTEX AILANTHI to add 10-14 times to measure water by formula, soak 20-40 minutes, extract 2 times, each 1.5-2.5 is small When.
- The preparation method of rash foaming agent 5. bitter eucalyptus according to claim 3 is dispelled, it is characterised in that：The step（2）In, press Formula takes golden cypress, frutus cnidii to add 7-9 times to measure 75% ethanol, extracts 2 times, each 1-2 hours.
- The preparation method of rash foaming agent 6. bitter eucalyptus according to claim 3 is dispelled, it is characterised in that：The step（3）In, press Formula takes Pogostemon cablin, eucalyptus robusta to add 10-14 times to measure water, soaks 1-2 hours, extracts 4-6 hours, extracts to obtain volatile oil.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908512A (en) * | 2013-01-08 | 2014-07-09 | 国药控股深圳中药有限公司 | Preparation methods of traditional Chinese medicine gel and traditional Chinese medicine lotion for treating dermatopathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908512A (en) * | 2013-01-08 | 2014-07-09 | 国药控股深圳中药有限公司 | Preparation methods of traditional Chinese medicine gel and traditional Chinese medicine lotion for treating dermatopathy |
Non-Patent Citations (2)
| Title |
|---|
| 纳米银抗菌微乳泡沫剂的制备及检验方法研究;崔藴慧等;《中国卫生检验杂志》;20130430;第23卷(第4期);第870-873页 * |
| 苦桉祛疹凝胶中苦参、地肤子、椿皮的水提工艺研究;刘志刚等;《今日药学》;20150325;第25卷(第3期);第160-162页 * |
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