CN104798790A - Sterilizing composition containing SYP-Z048 and picoxystrobin - Google Patents
Sterilizing composition containing SYP-Z048 and picoxystrobin Download PDFInfo
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Abstract
The invention discloses a sterilizing composition containing SYP-Z048 and picoxystrobin and application thereof. Effective active ingredients of the sterilizing composition consist of a first active ingredient SYP-Z048 and a second active ingredient picoxystrobin, wherein the weight ratio of the first active ingredient to the second active ingredient is (1:40)-(40:1), preferably (1:20)-(20:1); the sum of contents of the first active ingredient and the second active ingredient accounts for 1%-60% of the total weight of the composition. The composition can be prepared into a suspending agent, a water dispersible granule, wettable powder, dispersible oil suspension, emulsion in water, missible oil and a micromulsion which are agriculturally allowable. The sterilizing composition is reasonable in ingredient and good in sterilizing effect and achieves an activity and a sterilizing effect which are not obtained by simply superposing activities of the ingredients; compared with an existing single preparation, the sterilizing composition has a remarkable synergistic effect and good safety for crops in addition to a remarkable sterilizing effect. The sterilizing composition has a remarkable prevention and treatment effect on vegetable gray mold, leaf mold, powdery mildew and apple altermaria leaf spot.
Description
Technical field
The present invention relates to a kind of bactericidal composition, be made up of the first active component SYP-Z048 and the second active component ZEN 90160 and auxiliary agent, belong to technical field of compounded pesticide.
Background technology
SYP-Z048, chemical name: N-methyl-3-(4-chlorine) phenyl-5-methyl-5-pyridine-3-methyl-oxazoline is the bactericide of Shenyang chemical industry institute initiative, has significant inhibitory action to the ergosterol synthesis of fungi.This compound has the bactericidal activity of wide spectrum; treatment, protection and systemic activity; to the plurality of plant diseases that sac fungi, basidiomycetes and imperfect fungus cause, there is good preventive and therapeutic effect; be mainly used in preventing and treating gray mold, spot defoliation, powdery mildew etc.; with existing bactericide without cross resistance, have broad application prospects.Field using dosage is 200-400g(a.i.)/hm2.SYP-Z048 will expire on July 13rd, 2019 in the patent (CN11144590C) of China.
ZEN 90160, English name picoxystrobin, chemical name: (E)-3-methoxy-2-[2-[6-(trifluoromethyl)-2-pyridine oxygen methyl] phenyl] methyl acrylate, be mitochondrial respiratory inhibitor, namely suppress mitochondrial breathing by electro transfer between cytochrome b and C1.Prevent and treat the bacterial strain of 14-demethylation enzyme inhibitor, benzamides, tri carboxylic acid amide class and benzimidazole generation resistance effective.ZEN 90160, once be absorbed by blade, will move, flow with current in transportation system in xylem; It also flows in the gas phase of blade surface, and flows in xylem again after from gas phase, absorption enters blade.Just because of systemic activity and the fumigation activity of ZEN 90160, thus after dispenser, active ingredient can effectively be reallocated and fully transmit, and therefore ZEN 90160 has better therapeutic activity than commercial Fluoxastrobin and oxime bacterium ester.ZEN 90160 and other bactericide at home market used at present without cross resistance, can in plant corpus, in soil and water fast degradation, having protection, treat, root out, osmosis, is the extremely potential pesticide species of a class.
Eliminating vegetable botrytis be on the vegetables such as tomato, cucumber, capsicum, eggplant Major Diseases.This disease have infect fast, develop the features such as rapid, wayward.Often cause a large amount of decayed fruit, loss can reach 40% ~ 60%.Production prevents and treats the medicament of such disease based on thiophanate-methyl, iprodione, Boscalid, procymidone, long-term a large amount of use, ash arrhizus bacteria creates resistance gradually to these medicaments.
Leaf mold is that greenhouse tomato generally occurs, endangers serious a kind of disease, often causes blade early withered and uproots plants after their edible portions have been harvested ahead of time, with tomato downy mildew, graw mold of tomato claiming, is tomato, the Major Diseases that need prevent and treat of cucumber, grape, the economic crops such as watermelon.
Spot defoliation has generation in each apple producing region, is injured heavier with Bohai Sea Gulf and area, the ancient riverbed of the Yellow River.Be the important disease of new red magnitude marshal system apple, cause apple early leaf fall, cause tree vigo(u)r weak, fruit output and quality reduce, and storage period also easily infects other germs, causes rotten.
Powdery mildew of cucumber is commonly called as " white defect ", is injured the heaviest, is secondly petiole and stem, does not generally endanger fruit with blade.When occurring serious, mildew even can cover full leaf, has a strong impact on photosynthesis, and eubolism is interfered, causes early ageing, output incurs loss.
Although at present SYP-Z048 and ZEN 90160 are with other bactericide all without cross resistance, As time goes on the continuous increase of usage amount, pathogen is one certainty to its generation resistance.Applicant is through retrieval, also there is no the bibliographical information of SYP-Z048 and the control of ZEN 90160 mixture eliminating vegetable botrytis, leaf mold, powdery mildew and alternaria leaf spot of apple at present, be further advanced by test to find, by SYP-Z048s different for the mechanism of action and ZEN 90160 composite, there is obvious synergistic effect, the control efficiency to eliminating vegetable botrytis, leaf mold, powdery mildew and alternaria leaf spot of apple can be significantly improved, reduce dosage, reduce cost accounting, high to crop safety.
Summary of the invention
The object of the present invention is to provide a kind of component reasonable, synergistic effect is remarkable, and bactericidal effect is good, and drug cost is low, to the agricultural bactericidal composition of crop safety.
The bactericidal composition preparation formulation provided containing SYP-Z048 and ZEN 90160 is provided.
Another object of the present invention is to provide the application of above-mentioned composition on control eliminating vegetable botrytis, leaf mold, powdery mildew and alternaria leaf spot of apple.
In order to overcome the defect of existing unitary agent, technical scheme of the present invention solves like this:
A) the first active component SYP-Z048;
B) the second active component ZEN 90160.
The weight ratio of the first active component and the second active component is 1:40 ~ 40:1, is preferably 1:20 ~ 20:1.
The content sum of the first active component and the second active component is 1% ~ 60% of described composition total weight.
The preparation formulation that a kind of bactericidal composition containing SYP-Z048 and ZEN 90160 of the present invention can be prepared according to the method that those skilled in the art of the present technique are known is suspending agent, water dispersible granules, wetting powder, dispersible oil-suspending agent, aqueous emulsion, missible oil, microemulsion.
To suspending agent, spendable auxiliary agent has: dispersant is polycarboxylate, lignosulfonates, alkyl naphthalene formaldehyde condensate sulfonates, alkylphenol-polyethenoxy base ether phosphate, alkylphenol-polyethenoxy base ether sulfonate, phenethyl phenol polyethenoxy base ether phosphate, alkyl polyoxyethylene ether sulfonate, polyoxyethylene polyoxypropylene base ether block copolymers, to pull open in powder, alkylpolyoxyethylene phosphate one or more; Wetting agent is alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, alkylnaphthalene sulfonate, in alkyl phenol formaldehyde resin polyoxyethylene ether, triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer one or more; Thickener be in xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose one or more; Preservative be in formaldehyde, benzoic acid, Sodium Benzoate, potassium sorbate, isothiazolinone one or more; Defoamer is silicone oil, silicone compound, C10-20 saturated fat acid compounds, C8-10 aliphatic alcohols, hexanol, one or more in butanols, octanol; Antifreezing agent be in ethylene glycol, propane diols, glycerine, polyethylene glycol, sorbierite, urea, inorganic salts one or more; Water is deionized water.
For water dispersible granules, those skilled in the art are familiar with the corresponding auxiliary agent of use and complete the present invention very much.Dispersant as in polycarboxylate (TERSPERSE 2700, T36, GY-D06 etc.), lignosulfonates, alkylnaphthalene sulfonate one or more; Wetting agent as in alkyl sulfate, alkylsulfonate, naphthalene sulfonate one or more; Disintegrant as in ammonium sulfate, sodium sulphate, polyvinylpyrrolidone, starch and derivative thereof, bentonite one or more; Binding agent is as one or more in starch, glucose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, sucrose; Filler as diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To wetting powder, spendable auxiliary agent has: dispersant be in polycarboxylate, lignosulfonates, polyoxyethylene polyoxypropylene base ether block copolymers, alkyl naphthalene formaldehyde condensate sulfonates, alkylphenol-polyethenoxy base ether phosphate, aliphatic alcohol polyoxyvinethene phosphate, alkylphenol-polyethenoxy base ether sulfonate one or more; Wetting agent be in alkyl sulfate, alkylsulfonate, alkylnaphthalene sulfonate one or more; Filler be ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To dispersibling oil-suspending agent, spendable auxiliary agent has: dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), Huntsman Corporation of TERSPERSE 2020(U.S. HUNTSMAN produce, alkyl naphthalene sulfonic acid salt) in one or more, emulsifier is as BY(castor oil polyoxyethylene ether) serial emulsifier (BY-110, BY-125, BY-140), Nongru-700 #(common name: alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this dish-60#(common name: sorbitan monostearate), Tween-60 #(common name: sorbitan monostearate APEO), agriculture breast 1601#(common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), Huntsman Corporation of the TERSPERSE 4894(U.S. produce) in one or more, wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol polyoxyethylene phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, Huntsman Corporation of the TERSPERSE 2500(U.S. produce) in one or more, thickener as in white carbon, polyvinyl alcohol, bentonite, aluminium-magnesium silicate one or more, antifreezing agent as ethylene glycol, propane diols, glycerine, urea, inorganic salts as in sodium chloride one or more, dispersion medium as in soybean oil, rapeseed oil, corn oil, methyl oleate, diesel oil, machine oil, mineral oil one or more.
To aqueous emulsion, spendable auxiliary agent has: emulsifier is as Nonyl pheno (EO=10) ether phosphate, triphenoethyl benzene phenol polyethenoxy ether phosphate, Nongru-700 #(common name: alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201#, this dish-60#(common name: Span60), Tween-60 #(common name: polyoxyethylene sorbitan stearate), TX-10(common name: octyl phenol polyoxyethylene (10) ether), agriculture breast 1601(common name: triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer), agriculture breast 600#, agriculture breast 400# in one or more, solvent as dimethylbenzene, toluene, cyclohexanone, solvent naphtha (trade mark: S-150, S-180, S-200) one or more, stabilizing agent as in triphenyl phosphite, epoxychloropropane, epoxidized soybean oil one or more, antifreezing agent as ethylene glycol, propane diols, glycerine, urea, inorganic salts as in sodium chloride one or more, thickener as in xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate one or more, preservative as in formaldehyde, benzoic acid, Sodium Benzoate one or more, water is deionized water.
For missible oil, spendable auxiliary agent has: emulsifier as calcium dodecyl benzene sulfonate (agriculture breast 500#), Nongru-700 #, agriculture breast 2201, this coil-60#, emulsifier T-60(common name: anhydrous sorbitol single-hard ester acid ester APEO), TX-10(common name: octyl phenol polyoxyethylene (10) ether), one or more in agriculture breast 1601#, agriculture breast 600#, the newborn 400# of agriculture; Solvent is as one or more in dimethylbenzene, solvent naphtha (S-150, S-180, S-200), toluene, biodiesel, methylated vegetable oil; Cosolvent is as one or more in ethyl acetate, methyl alcohol, dimethyl formamide, cyclohexanone, acetone, MEK; Stabilizing agent is as one or more in triphenyl phosphite, epoxychloropropane, aceticanhydride.
For microemulsion, spendable auxiliary agent has: emulsifier is as calcium dodecyl benzene sulfonate (agriculture breast 500#), Nongru-700 #, agriculture breast 2201, this dish-60#, polysorbate60-#, TX-10, agriculture breast 1601(common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), one or more in agriculture breast 600#, agriculture breast 400#; Assistant for emulsifying agent is as one or more in methyl alcohol, isopropyl alcohol, n-butanol, ethanol; Solvent is as one or more in cyclohexanone, 1-METHYLPYRROLIDONE, dimethylbenzene, toluene, solvent naphtha (trade mark: S-150, S-180, S-200); Stabilizing agent is as one or more in triphenyl phosphite, epoxychloropropane; Water is deionized water.
Instant component is reasonable, and treatment adds protective effect, and bactericidal effect is good, and drug cost is low, and its activity and bactericidal effect are not the simple superposition of each composition activity, but has significant synergistic effect, good to crop safety, meets the security requirement of pesticidal preparations.The present invention has good control efficiency to eliminating vegetable botrytis, leaf mold, powdery mildew and alternaria leaf spot of apple.
Embodiment
Illustrate that SYP-Z048 and ZEN 90160 mixture are to the synergistic effect of graw mold of tomato, cladosporium leaf and fruit mould of tomato, alternaria leaf spot of apple, powdery mildew of cucumber below by Toxicity Determination.
In order to prevent and treat graw mold of tomato, cladosporium leaf and fruit mould of tomato, the alternaria leaf spot of apple in agricultural production, we have carried out mutual composite synergy with SYP-Z048 and ZEN 90160 and have studied, and concrete grammar is:
Subjects be botrytis cinerea (
botrytis cinerea), Fulvia fulva (
fulvia fulva), Alternaria mali (
alternaria mali).Former medicine is mixed with the test medicine of needs, test method is with reference to " farm-chemical indoor determination test rule bactericide the 6th part: the synergy of mixture measures ".First single dose and each Mixed Pharmacy are arranged 5 variable concentrations gradients (on the basis of preliminary experiment, bacteriostasis rate sets by geometric progression in the scope of 5% ~ 90%).If blank, repeat 4 times.Adopt mycelial growth rate method, by cultured pathogen, be aseptically the card punch of 5mm with diameter, cut bacterium cake from colony edge, with transfer needle, bacterium cake is connected on the culture medium flat plate of variable concentrations, be placed in 26 DEG C of insulating boxs and cultivate 72h.With the growth diameter of vernier caliper measurement bacterium colony, calculate the percentage that each process suppresses mycelial growth, by the linear regression analysis between inhibiting rate probability value and the logarithm value of series concentration, obtain the EC of each medicament
50value.
Calculate the co-toxicity coefficient (CTC) of mixture by the abundant method of Sun Yun, evaluate the activity of reagent agent to germ with this.The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect; CTC≤80 show as antagonism; 80 < CTC < 120 show as summation action.
Table 1 SYP-Z048 and ZEN 90160 combine the Toxicity Determination to graw mold of tomato
Table 2 SYP-Z048 and ZEN 90160 combine the Toxicity Determination to cladosporium leaf and fruit mould of tomato
Table 3 SYP-Z048 and ZEN 90160 combine the Toxicity Determination to alternaria leaf spot of apple
Toxicity Determination result shows that: SYP-Z048 and ZEN 90160 are that 1:40 ~ 40:1 is mixed with weight ratio and all have good virulence to graw mold of tomato, cladosporium leaf and fruit mould of tomato, alternaria leaf spot of apple, and synergistic effect is remarkable.
In order to prevent and treat the powdery mildew of cucumber in agricultural production, we have carried out mutual composite synergy with SYP-Z048 and ZEN 90160 and have studied, and concrete grammar is:
Subjects be cucumber powdery mildew's pathogen (
sphaerotheca fuliginea).Former medicine is mixed with the test medicine of needs, test method is with reference to " farm-chemical indoor determination test rule bactericide the 6th part: the synergy of mixture measures " and " farm-chemical indoor determination test rule bactericide the 11st part: control cucurbits powdery mildew test pot-culture method ".First single dose and each Mixed Pharmacy are arranged 5 variable concentrations gradients (on the basis of preliminary experiment, bacteriostasis rate sets by geometric progression in the scope of 5% ~ 90%).If blank, repeat 4 times.Adopt pot-culture method, liquid is evenly sprayed in blade face, for subsequent use after liquid natural air drying.Using spore suspension spray inoculation, natural air drying, then move to thermostatic chamber, is under the condition of 20 ~ 24 DEG C in temperature, cultivates 7d ~ 10d.When the sick leaf rate of blank reaches more than 80%, classification investigation manages incidence everywhere, often processes and at least investigates 30 leaves.According to survey data, calculate disease index and the control efficiency of each process.By the linear regression analysis between preventive effect probability value and the logarithm value of series concentration, obtain the EC of each medicament
50value.
Calculate the co-toxicity coefficient (CTC) of mixture by the abundant method of Sun Yun, evaluate the activity of reagent agent to germ with this.The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect; CTC≤80 show as antagonism; 80 < CTC < 120 show as summation action.
Table 4 SYP-Z048 and ZEN 90160 combine the Toxicity Determination to powdery mildew of cucumber
Toxicity Determination result shows that: SYP-Z048 and ZEN 90160 are that 1:40 ~ 40:1 is mixed with weight ratio and have good virulence to powdery mildew of cucumber, and synergistic effect is remarkable.
Below in conjunction with embodiment, content of the present invention is described further.
Example of formulations 1
Take 1% SYP-Z048,40% ZEN 90160,2% sodium naphthalene sulfonate, 5% sodium lignin sulfonate, 0.3% aluminium-magnesium silicate, 0.2% bentonite, 5% propane diols, 0.2% Sodium Benzoate, 1% hexanol, deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear dispersion 30min, with sand mill sand milling to particle diameter D
90obtained 41% SYP-Z048 ZEN 90160 suspending agent after being less than 10 μm.
Example of formulations 2
Take 20% SYP-Z048,10% ZEN 90160,3% polycarboxylate, 2% phenethyl phenol polyethenoxy base ether phosphate, 0.5% carboxymethyl cellulose, 3% polyethylene glycol, 0.2% potassium sorbate, 01% octanol, deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear dispersion 30min, with sand mill sand milling to particle diameter D
90obtained 30% SYP-Z048 ZEN 90160 suspending agent after being less than 10 μm.
Example of formulations 3
Take 20% SYP-Z048,30% ZEN 90160,2% TERSPERSE 2700(polycarboxylate, Huntsman Corporation of the U.S. produce), 2% sodium lignin sulfonate, 1% Nekal BX (nekal), 1%K-12(lauryl sodium sulfate), 1% polyvinyl alcohol (PVA molecular weight 2000), 2% starch, white carbon adds to 100% weight portion.Namely the method for above-mentioned raw materials frequent regulation water intaking dispersible granule mixes, ultra micro air-flow crushing, mixing, granulation step produce 50% SYP-Z048 ZEN 90160 water dispersible granules.
Example of formulations 4
Take 30% SYP-Z048,15% ZEN 90160,2% T36(polycarboxylate), 2% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 2%K-12(lauryl sodium sulfate), potter's clay adds to 100% weight portion.Namely the method for above-mentioned raw materials frequent regulation water intaking dispersible granule mixes, ultra micro air-flow crushing, mixing, granulation step produce 45% SYP-Z048 ZEN 90160 water dispersible granules.
Example of formulations 5
Take 2% SYP-Z048,40% ZEN 90160,4% polyoxyethylene polyoxypropylene base ether block copolymers, 3% lignosulfonates, 3% lauryl sodium sulfate, talcum powder fills up the weight portion to 100%.Above-mentioned raw materials is prepared into 42% SYP-Z048 ZEN 90160 wetting powder through mixing, ultra micro air-flow crushing, hybrid technique step.
Example of formulations 6
Take 24% SYP-Z048,12% ZEN 90160,6% calcium lignosulfonate, 4% alkylnaphthalene sulfonate formaldehyde condensation products, 2% lauryl sodium sulfate, white carbon fills up the weight portion to 100%.Above-mentioned raw materials is prepared into 36% SYP-Z048 ZEN 90160 wetting powder through mixing, ultra micro air-flow crushing, hybrid technique step.
Example of formulations 7
Take 20% SYP-Z048,25% ZEN 90160, Huntsman Corporation of the 2%TERSPERSE 2020(U.S. produce), 4% BY-125#, 3% Tween-60 #, 4% agriculture breast 2201#, 3% Huntsman Corporation of Nongru-700 #, 1%TERSPERSE 2500(U.S. produce), 2% white carbon, 5% polyvinyl alcohol, soybean oil adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear dispersion 30min, dispersibles oil-suspending agent with making 45% SYP-Z048 ZEN 90160 after sand mill sand milling.
Example of formulations 8
Take 32% SYP-Z048,16% ZEN 90160,2% dispersing agent NNO, 3% this dish-60#, 8% Huntsman Corporation of BY-110,1%TERSPERSE 2500(U.S. produce), 1% bentonite, 3% glycerine, castor oil adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear dispersion 30min, dispersibles oil-suspending agent by 48% SYP-Z048 ZEN 90160 obtained after sand mill sand milling.
Example of formulations 9
Take 40% SYP-Z048,2% ZEN 90160,3% agriculture breast 2201#, 2% Nonyl pheno (EO=10) ether phosphate, 2% Tween-60 #, 2% this dish-60#, 5% propane diols, 10% solvent naphtha S-180,5% cyclohexanone, 0.2% xanthans, 0.5% benzoic acid, deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear emulsification obtains 42% SYP-Z048 ZEN 90160 aqueous emulsion.
Example of formulations 10
Take 40% SYP-Z048,20% ZEN 90160,8% agriculture breast TX-10#, 2% Nonyl pheno (EO=10) ether phosphate, 4% triphenoethyl benzene phenol polyethenoxy ether phosphate, 2% this dish-60#, 1% epoxychloropropane, 2% ethylene glycol, 5% dimethylbenzene, 0.2% xanthans, 0.5% benzoic acid, deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear emulsification obtains 60% SYP-Z048 ZEN 90160 aqueous emulsion.
Example of formulations 11
Take 40% SYP-Zo48,1% ZEN 90160,4% agriculture breast 500#, 3% agriculture breast 400#, 5% agriculture breast 1601#, 1% epoxychloropropane, 15% ethyl acetate, 10% acetone, biodiesel adds to 100% weight portion.Above-mentioned raw materials is through mixing, and stirring and dissolving is obtained 41% SYP-Z048 ZEN 90160 missible oil completely afterwards.
Example of formulations 12
Take 36% SYP-Zo48,18% ZEN 90160,4% agriculture breast 500#, 2% agriculture breast 600#, 3% agriculture breast 2201#, 3% triphenyl phosphite, 15% dimethyl formamide, dimethylbenzene adds to 100% weight portion.Above-mentioned raw materials is through mixing, and stirring and dissolving is obtained 54% SYP-Z048 ZEN 90160 missible oil completely afterwards.
Example of formulations 13
Take 0.5% SYP-Zo48,0.5% ZEN 90160,4%TX-10,5% Nongru-700 #, 6% agriculture breast 500#, 4% agriculture breast 1601#, 15% cyclohexanone, 5%N-methyl pyrrolidone, 5% n-butanol, through dissolving completely and mixing, deionized water adds to 100% weight portion, obtained 1% SYP-Z048 ZEN 90160 microemulsion after stirring.
Example of formulations 14
Take 12% SYP-Zo48,6% ZEN 90160,5% agriculture breast 400#, 4% agriculture breast 500#, 6% agriculture breast 1601#, 25% cyclohexanone, 5% dimethylbenzene, 5% isobutanol, through dissolving completely and mixing, deionized water adds to 100% weight portion, obtained 18% SYP-Z048 ZEN 90160 microemulsion after stirring.
Biological Examples 1: control graw mold of tomato field trial
Within 2014, carried out example of formulations 2(30% SYP-Z048 ZEN 90160 suspending agent in Jingyang County, Shaanxi Province), example of formulations 4(45% SYP-Z048 ZEN 90160 water dispersible granules) prevent and treat graw mold of tomato field trial, demonstrate the control efficiency of this medicament to graw mold of tomato and the safety to tomato.Trial crops is tomato, controlling object be graw mold of tomato (
botrytis cinerea).Test is located at Yunyang town, Jingyang County, and experimental field physical features is smooth, and soil is loam, middle fertility, pH value 6.9, and duration of test rich water quality management is medium.Test medicine and dosage refer to table 5.Separately establish blank, often process 4 times and repeat, every community 30 ㎡, Gong20Ge community, random district group arranges.Adopt conventional spray-on process, mu dispenser liquid 45kg, is evenly sprayed at leave dual sides.
Investigation and statistical method: before the 1st dispenser, investigate state of an illness radix, after last dispenser, 10 ~ 14d reinvestigates once, investigate 2 times, dispenser 2 times altogether.Every community adopts five point samplings, and often some investigation 2 ~ 3 strains, investigate whole blades of every strain, calculate disease index.Graw mold of tomato grade scale (in units of blade):
0 grade: without scab;
1 grade: single blade has scab 3;
3 grades: single blade has scab 4 ~ 6;
5 grades: single blade has scab 7 ~ 10;
7 grades: single blade has scab 11 ~ 20, and part is in flakes intensive;
9 grades: single blade has that scab is intensive accounts for leaf area more than 1/4th.
Disease index=[∑ (the sick number of sheets × relative level numerical value at different levels)/(investigation total leaf number × 9)] × 100
Control efficiency (%)=[1-(before contrast dispenser after disease index × process dispenser disease index)/(to contrast after dispenser disease index before disease index × process dispenser] × 100
graw mold of tomato field test results prevented and treated by table 5
Field test results shows, 30% SYP-Z048 ZEN 90160 suspending agent, 45% SYP-Z048 ZEN 90160 water dispersible granules have good control efficiency to graw mold of tomato, respectively by 1500 times, 2000 times dilution sprayings 2 times, after 2nd medicine, the preventive effect of 10 days is respectively 92.34%, 89.95%, is obviously better than the preventive effect of 25%% SYP-Z048 missible oil 750 times, 22.5% ZEN 90160 suspending agent 1500 times.By analyzing 10 days preventive effect significances of difference after the 2nd medicine, difference reaches pole significance level (see table 5).
To the security survey of tomato, within after spray medicine after the 1st day and medicine some days, observe, each test process occurs without poisoning phenomenon tomato.
Biological Examples 2: prevent and treat cladosporium leaf and fruit mould of tomato field trial
Within 2014, carried out example of formulations 6(36% SYP-Z048 ZEN 90160 wetting powder in Jingyang County, Shaanxi Province), embodiment 8(48% SYP-Z048 ZEN 90160 dispersibles oil-suspending agent) prevent and treat cladosporium leaf and fruit mould of tomato field trial, demonstrate the control efficiency of this medicament to cladosporium leaf and fruit mould of tomato and the safety to tomato.Trial crops is tomato, controlling object be cladosporium leaf and fruit mould of tomato (
fulvia fulva).Test is located at Yunyang town, Jingyang County, and experimental field physical features is smooth, and soil is loam, middle fertility, pH value 6.9, and duration of test rich water quality management is medium.Test medicine and dosage refer to table 6.Separately establish blank, often process 4 times and repeat, every community 30 ㎡, Gong20Ge community, random district group arranges.Adopt conventional spray-on process, mu dispenser liquid 45kg, is evenly sprayed at leave dual sides.
Investigation and statistical method: before the 1st dispenser, investigate state of an illness radix, after last dispenser, 10 ~ 14d reinvestigates once, investigate 2 times, dispenser 2 times altogether.The sampling of 3, every community, often some investigation 5 strains, every strain point upper, middle and lower part gets a representational compound leaf, so that compound leaf often to open the percentage classification that vanelets lesion area accounts for whole vanelets area, calculates disease index.Cladosporium leaf and fruit mould of tomato grade scale:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for 5% ~ 10% of whole leaf area;
5 grades: lesion area accounts for 11% ~ 20% of whole leaf area;
7 grades: lesion area accounts for 21% ~ 50% of whole leaf area;
9 grades: lesion area accounts for more than 51% of whole leaf area.
Disease index=[∑ (the sick number of sheets × relative level numerical value at different levels)/(investigation total leaf number × 9)] × 100
Control efficiency (%)=[1-(before contrast dispenser after disease index × process dispenser disease index)/(to contrast after dispenser disease index before disease index × process dispenser] × 100
cladosporium leaf and fruit mould of tomato field test results prevented and treated by table 6
Field test results shows, 36% SYP-Z048 ZEN 90160 wetting powder, 48% SYP-Z048 ZEN 90160 dispersibles oil-suspending agent has good control efficiency to cladosporium leaf and fruit mould of tomato, respectively by 1500 times, 2000 times dilution sprayings 2 times, 91.55%, 89.75% is respectively to the preventive effect of 10 days after cladosporium leaf and fruit mould of tomato the 2nd medicine, is obviously better than the preventive effect of 25% SYP-Z048 missible oil 750 times, 22.5% ZEN 90160 suspending agent 1500 times.By analyzing 10 days preventive effect significances of difference after medicine, difference reaches pole significance level (see table 6).
To the security survey of tomato, within after spray medicine after the 1st day and medicine some days, observe, each test process occurs without poisoning phenomenon tomato.
Biological Examples 3: control alternaria leaf spot of apple field trial
Within 2014, carried out example of formulations 10(60% SYP-Z048 ZEN 90160 aqueous emulsion in Liquan County, Shaanxi Province), embodiment 12(54% SYP-Z048 ZEN 90160 missible oil) prevent and treat alternaria leaf spot of apple field trial, demonstrate the control efficiency of this medicament to alternaria leaf spot of apple and the safety to apple tree.Trial crops is apple tree, controlling object be alternaria leaf spot of apple (
alternaria mali).Test is located at Shi De town, Liquan County, and experimental field physical features is smooth, and soil is loam, middle fertility, pH value 6.9, and duration of test rich water quality management is medium.Test medicine and dosage refer to table 7.Separately establish blank, often process 4 times and repeat, the strain of every community 2 is set, Gong20Ge community, and random district group arranges.Adopt conventional spray-on process, be evenly sprayed at leave dual sides.
Investigation and statistical method: every community two strain is all investigated, every strain divide East, West, South, North, in 5 directions fix 2 new slightly (the spring tip and autumn growth), its whole blade of periodic investigation, records total number of sheets, the sick number of sheets at different levels.Stage division:
0 grade: without scab;
1 grade: lesion area accounts for less than 10% of whole leaf area;
3 grades: lesion area accounts for 11% ~ 25% of whole leaf area;
5 grades: lesion area accounts for 26% ~ 40% of whole leaf area;
7 grades: lesion area accounts for 41% ~ 65% of whole leaf area;
9 grades: lesion area accounts for more than 66% of whole leaf area.
Disease index=[∑ (the sick number of sheets × relative level numerical value at different levels)/(investigation total leaf number × 9)] × 100
Control efficiency (%)=[1-(before contrast dispenser after disease index × process dispenser disease index)/(to contrast after dispenser disease index before disease index × process dispenser] × 100
alternaria leaf spot of apple field test results prevented and treated by table 7
Field test results shows, 60% SYP-Z048 ZEN 90160 aqueous emulsion, 54% SYP-Z048 ZEN 90160 missible oil have good control efficiency to wheat powdery mildew, respectively by 1500 times, 2000 times dilution sprayings 5 times, 92.47%, 90.62% is respectively to the preventive effect of 10 days after alternaria leaf spot of apple the 5th medicine, is obviously better than the preventive effect of 25% SYP-Z048 missible oil 1500 times, 22.5% ZEN 90160 suspending agent 1500 times.By analyzing 10 days preventive effect significances of difference after last medicine, difference reaches pole significance level (see table 7).
To the security survey of apple tree, within after spray medicine after the 1st day and medicine some days, observe, each test process occurs without poisoning phenomenon apple tree.
Biological Examples 4: prevent and treat powdery mildew of cucumber field trial
Within 2014, carry out example of formulations 14(18% SYP-Z048 ZEN 90160 microemulsion in Shouguang City of Shandong Province) prevent and treat powdery mildew of cucumber field trial, demonstrate the control efficiency of this medicament to powdery mildew of cucumber and the safety to cucumber.Trial crops is cucumber, controlling object be powdery mildew of cucumber (
sphaerotheca fuliginea).Test is located at rice field town, Shouguang City, and experimental field physical features is smooth, and soil is loam, middle fertility, pH value 6.9, and duration of test rich water quality management is medium.Test medicine and dosage refer to table 8.Separately establish blank, often process 4 times and repeat, every community 30 ㎡, Gong16Ge community, random district group arranges.Adopt conventional spray-on process, mu dispenser liquid 45kg, is evenly sprayed at leave dual sides.
Investigation and statistical method: investigate state of an illness radix before dispenser, after last dispenser, 10 ~ 14d reinvestigates once, investigate 2 times altogether.Every community gets 4 points at random, and whole blades of often some investigation 2 strains, every sheet leaf accounts for the percentage classification record of leaf area according to scab.Stage division:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for 6% ~ 10% of whole leaf area;
5 grades: lesion area accounts for 11% ~ 20% of whole leaf area;
7 grades: lesion area accounts for 21% ~ 40% of whole leaf area;
9 grades: lesion area accounts for more than 40% of whole leaf area.
Disease index=[∑ (the sick number of sheets × relative level numerical value at different levels)/(investigation total leaf number × 9)] × 100
Control efficiency (%)=[1-(before contrast dispenser after disease index × process dispenser disease index)/(to contrast after dispenser disease index before disease index × process dispenser] × 100
powdery mildew of cucumber field test results prevented and treated by table 8
Field test results shows, 18% SYP-Z048 ZEN 90160 microemulsion has good control efficiency to powdery mildew of cucumber, respectively by 1000 times of dilution sprayings 2 times, 93.04% is respectively to the preventive effect of 10 days after powdery mildew of cucumber the 2nd medicine, is obviously better than the preventive effect of 25% SYP-Z048 missible oil 750 times, 22.5% ZEN 90160 suspending agent 1500 times.By to significance of difference analysis in 10 days after medicine, difference reaches pole significance level (see table 8).
To the security survey of cucumber, within after spray medicine after the 1st day and medicine some days, observe, each test process occurs without poisoning phenomenon cucumber.
After above 4 result of the tests show SYP-Z048 and ZEN 90160 mixture, significantly improve the control efficiency to graw mold of tomato, cladosporium leaf and fruit mould of tomato, alternaria leaf spot of apple, powdery mildew of cucumber, synergistic effect is obvious, reduce dosage and drug cost, to tomato, apple, cucumber growth safety, it is the favourable agents of control graw mold of tomato, cladosporium leaf and fruit mould of tomato, alternaria leaf spot of apple, powdery mildew of cucumber.
From above embodiment, 1:40 ~ 40:1 is composite by weight for first active component SYP-Z048 and the second active component ZEN 90160, can be made into suspending agent, water dispersible granules, wetting powder, dispersible oil-suspending agent, aqueous emulsion, missible oil, micro-emulsion form, significant control efficiency is had to graw mold of tomato, cladosporium leaf and fruit mould of tomato, alternaria leaf spot of apple, powdery mildew of cucumber, synergistic effect is obvious, dosage is few, control efficiency is high, and good to crop safety.
In sum, composition of the present invention is employing two kinds of active component compound schemes, its activity and bactericidal effect are not the simple superposition of each composition activity, compared with existing unitary agent, except there is significant bactericidal effect, more there is significant synergistic effect, good to doing safety, meet the security requirement of pesticidal preparations.
Claims (6)
1. one kind contains the bactericidal composition of SYP-Z048 and ZEN 90160, it is characterized in that: active ingredient is made up of the first active component SYP-Z048 and the second active component ZEN 90160, and the weight ratio of the first active component and the second active component is 1:40 ~ 40:1.
2. contain the bactericidal composition of SYP-Z048 and ZEN 90160 according to claim 1, it is characterized in that, the weight ratio of the first active component and the second active component is 1:20 ~ 20:1.
3. contain the bactericidal composition of SYP-Z048 and ZEN 90160 according to claim 1, it is characterized in that, the content sum of the first active component and the second active component is 1% ~ 60% of described composition total weight.
4. the bactericidal composition according to claim 1 containing SYP-Z048 and ZEN 90160, is characterized in that described combination dosage form is suspending agent, water dispersible granules, wetting powder, dispersibles oil-suspending agent, aqueous emulsion, missible oil, microemulsion.
5. the bactericidal composition according to claim 1 containing SYP-Z048 and ZEN 90160 is preventing and treating the purposes on crops gray mold, leaf mold, powdery mildew, spot defoliation.
6. purposes according to claim 5, crops gray mold is graw mold of tomato, crops leaf mold is cladosporium leaf and fruit mould of tomato, crop powdery mildew is powdery mildew of cucumber, crops spot defoliation is alternaria leaf spot of apple.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106852332A (en) * | 2015-12-08 | 2017-06-16 | 中化农化有限公司 | Bactericidal composition containing SYP-Z048 |
| CN106857550A (en) * | 2015-12-11 | 2017-06-20 | 沈阳中化农药化工研发有限公司 | It is a kind of containing the bactericide for stablizing component |
| CN111955468A (en) * | 2020-07-29 | 2020-11-20 | 京博农化科技有限公司 | Ternary weeding composition containing topramezone |
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| CN103355316A (en) * | 2013-08-03 | 2013-10-23 | 海利尔药业集团股份有限公司 | Bactericide composition containing N-methyl-3-(4-chloro)phenyl-5-methyl-5-pyridyl-3-methyl-oxazoline and methyl (E)-2-(2-((3-(4-chlorphenyl)-1-methyl-1H-pyrazolyl-5-oxy)methyl)phenyl-3-methoxyacrylate |
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| CN101087529A (en) * | 2004-12-23 | 2007-12-12 | 巴斯福股份公司 | Fungicidal mixtures |
| US20090227450A1 (en) * | 2005-09-16 | 2009-09-10 | Basf Aktiengesellschaft | Triazole-Based Fungicidal Mixtures |
| CN103355316A (en) * | 2013-08-03 | 2013-10-23 | 海利尔药业集团股份有限公司 | Bactericide composition containing N-methyl-3-(4-chloro)phenyl-5-methyl-5-pyridyl-3-methyl-oxazoline and methyl (E)-2-(2-((3-(4-chlorphenyl)-1-methyl-1H-pyrazolyl-5-oxy)methyl)phenyl-3-methoxyacrylate |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106852332A (en) * | 2015-12-08 | 2017-06-16 | 中化农化有限公司 | Bactericidal composition containing SYP-Z048 |
| CN106857550A (en) * | 2015-12-11 | 2017-06-20 | 沈阳中化农药化工研发有限公司 | It is a kind of containing the bactericide for stablizing component |
| CN106857550B (en) * | 2015-12-11 | 2019-11-12 | 沈阳中化农药化工研发有限公司 | It is a kind of containing the fungicide for stablizing component |
| CN111955468A (en) * | 2020-07-29 | 2020-11-20 | 京博农化科技有限公司 | Ternary weeding composition containing topramezone |
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