CN104758624A - Traditional Chinese medicine composition for treating gastric ulcer and preparation method of traditional Chinese medicine composition - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating gastric ulcer and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following medicinal materials: plum flower, akebia fruit, cynanchoides polygonum, rosewood heart wood, herb of Japanese ladyslipper, leaf of Chinese wampee, herb of dindygulen peperomia, rhizome of watt tupistra, herb of purpleflower stonecrop, root of Chinese peashrub, sampson st.john's wort herb, leaf of Yunnan craibiodendron, pseudobulb of appendiculate cremastra, bulb of longroot onion, root of littlespike willow, flower of balsampear, peel of roseapple, dried pickld pakchoi, herb of marsh orchis, rhizome of plateau jackinthepulpit and coriander fruit. The traditional Chinese medicine composition provided by the invention has the effects of clearing liver and adjusting stomach, regulating qi for relieving pain, promoting blood circulation to dispel blood stasis, soothing liver and eliminating heat, warming the middle and invigorating the spleen, as well as nourishing yin to harmonize the stomach. Moreover, the traditional Chinese medicine composition provided by the invention has the advantages of single and feasible preparation process obvious pharmacological effect and significant clinical effect, and is safe and effective.

Description

A kind of Chinese medicine composition for the treatment of gastric ulcer and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of gastric ulcer and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Gastric ulcer is one of common clinically digestive system disease, irregular in recent years with the quickening pace of modern life with diet, and the sickness rate of this type of disease rises to some extent.Its cardinal symptom is often rhythmicity epigastrium pain or the arythmia pain of chronic middle upper abdomen of recurrent exerbation, often accompanies acid regurgitation, glutted, heating installation, scorching hot, noisy etc., even Nausea and vomiting, hematemesis, has blood in stool.Gastric ulcer is because the too much secretion of gastric acid makes the top layer of gastric mucosa fester, this disease normally because minimal invasive treatment is irregular, smoking, drink, eating and drinking too much at one meal and mental pressure etc. cause.If patients w ith peptic ulcer disease is cured not in time, there will be the complication such as gastric perforation, gastrorrhagia, number can be developed to gastric cancer, serious threat patient vitals.The medicine of current western medicine gastric ulcer is more, and these medicines are merely able to eliminate facial pain symptom, do not remove the root of disease, and life-time service is all very large to the side effect of human body, and after treatment, easily recurrence, is usually difficult to radical cure.The present invention is the Chinese medicine composition providing a kind of gastric ulcer on the basis of theory of Chinese medical science and clinical practice, and relative to Western medicine, it has good effect, recurs low, the advantage of the secondary little effect of poison.

Primary disease belongs to the category of " gastric abscess " of motherland's medical science.Primary disease pathogenic factor mostly is long-term eating and drinking without temperance or direct stimulation.Feelings will is not smooth, injures in liver, irritability stasis, and perverse and unreasonable manner violates stomach, stomach-QI being unable to descend normally, irritable bowel syndrome, spleen loses transporting, and endogenous damp formation or turbid damp heat-transformation are damp and hot general, adverse rising of stomach-QI, and can stagnated QI transforming into fire and impairment of YIN further, caused by qi and cold stagnation and impairment of YANG, or form blood stasis pain by stagnation of QI blood-vessel obstructive.The sick position of primary disease is at stomach, but in close relations with liver, spleen.Primary disease Crack cause, also by intemperance of taking food, overstrain, makes the impaired generation disease of taste.Taste damaged is dysfunction of the spleen in transportation, stomach-QI being unable to descend normally then, mechanism of qi stagnation of QI and blood may bring about pain, and clear QI being mixed up with turbid QI is then let out, stomach-QI being unable to descend normally is then vomitted, and The spleen and stomach provide the material basis of the acquired, reservoir of food and drink, source of generating QI and blood, with the passing of time spleen injury does not heal, then easily cause the cards such as the deficiency of vital energy, blood deficiency, the deficiency of YIN, yang deficiency and all void of internal organs.Therefore pain initial stage common excess syndrome, sick then empty for a long time, simulataneous insufficiency and excessive, the syndrome that cold and heat cross-reference etc. are complicated.Chinese medicine thinks that stomach belongs to sun soil, preferring moisture to dryness, and being the big source of the vital organs of the human body, is the internal organs of the many blood of many gas, main digesting food of being received, its gas with reduce to suitable.Being invaded by exogenous pathogen, eating and drinking without temperance, disorder of emotion, overstrain all can the impairing the stomach, causes gastric qi to be become estranged, depression and stagnation of QI, stagnation of QI and blood may bring about pain, causes gastral cavilty to have a pain.But Chinese medicine and pharmacy treatment epigastric pain disease, compared with western medicine, has unique advantage and potential.

Summary of the invention

Features such as the invention provides a kind of Chinese medicine composition for the treatment of gastric ulcer and preparation method thereof, Chinese medicine composition of the present invention has treatment gastric ulcer determined curative effect, have no side effect and relapse rate is low.

We's prolonged application treatment clinically gastric ulcer, obtains good curative effect.Select Flos Pruni mume can soothing liver-QI in side, stomach function regulating, reduces phlegm.Fructus Akebiae, dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.In side, compatibility Polygonum cynanchoides Hemsl. can astringing lung-QI and relieving cough, circulation of qi promoting stomach invigorating, expelling wind and removing dampness.Rattan wingceltis, regulating QI to relieve pain.Tiger seven, regulating the flow of Qi and the middle Jiao, dispelling cold and removing dampness, promoting blood circulation and detumescence.Folium clausenae lansii, promoting the circulation of QI to relieve pain, stomach invigorating is subsided a swelling.Calyx Trapae, regulating qi-flowing for harmonizing stomach.Above-mentioned all medicines match, and make prescription have the merit of dispersing the stagnated liver-QI for regulating the stomach, regulating QI to relieve pain; Fang Zhongzai compatibility Herba Peperomiae Dindygulensis, eliminating stasis and resolving masses.Flat bamboo is surveyed, invigorating spleen to remove dampness, stomach function regulating, promoting blood circulation and detumescence.Herba Hylotelephii Mingjiniani, blood activating and promoting tissue regeneration, hemostasis removing toxic substances.Radix Caraganae Sinicae, lung heat clearing strengthening the spleen, blood circulation and channel invigorating.Herba Hyperici Sampsonii, invigorates blood circulation, hemostasis, removing toxic substances.Folium Craibiodendri Yunnanensis, relieving superficies and warmign meridians, activating collaterals to relieve pain.Pleionebulbocodioides rolfe, heat-clearing and toxic substances removing; Dispersing swelling and dissipating binds.Bulbus Allii Victorialis, dissipating blood stasis, hemostasis, removing toxic substances.Horse Radix Salicis Babylonicae, heat clearing away, pathogenic fire purging, pleasant.Flos Momordicae Charantiae, clearing away heat to cure dysentery, stomach function regulating.Prescription is made to have promoting blood circulation to remove blood stasis, soothing the liver effect expelled the heat-evil; Add Pericarpium syzygii again in rearmost, warming the stomach spleen invigorating, warming the lung to relieve cough, removing blood stasis is subsided a swelling.Fructus Litseae, warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain.Salted Brassicae siccus, YIN nourishing, appetizing, reduces phlegm, sharp diaphragm.Herba Orchidis Latifoliae, heart tonifying, the kidney invigorating, promotes the production of body fluid, and quenches the thirst, strengthening the spleen and stomach.Arisaema intermedium Blume, drying dampness to eliminate phlegm, stomach function regulating spleen invigorating, stopping nausea and vomiting by lowering the adverse flow of QI.Ceriander seed, rash of inducing sweat, invigorating the spleen and regulating the stomach, pungent loose pain relieving, circulation of qi promoting antidiarrheal.Prescription is made to have warming middle-JIAO and strengthening the spleen, effect of yin nourishing stomach function regulating.

The consumption of Chinese medicine composition of the present invention is also through that a large amount of clinical empirical summaries draws, and each amounts of components all has good curative effect in following weight parts scope:

It is made up of the crude drug of following weight portion: Flos Pruni mume 38 ~ 42 parts, Fructus Akebiae 18 ~ 22 parts, Polygonum cynanchoides Hemsl. 28 ~ 32 parts, 18 ~ 22 parts, rattan wingceltis, tiger 7 10 ~ 14 parts, Folium clausenae lansii 8 ~ 12 parts, Herba Peperomiae Dindygulensis 8 ~ 12 parts, flat bamboo surveys 16 ~ 20 parts, Herba Hylotelephii Mingjiniani 20 ~ 24 parts, Radix Caraganae Sinicae 14 ~ 18 parts, Herba Hyperici Sampsonii 16 ~ 20 parts, Folium Craibiodendri Yunnanensis 8 ~ 12 parts, pleionebulbocodioides rolfe 8 ~ 12 parts, Bulbus Allii Victorialis 14 ~ 18 parts, horse Radix Salicis Babylonicae 8 ~ 12 parts, Flos Momordicae Charantiae 7 ~ 11 parts, Pericarpium syzygii 7 ~ 11 parts, Salted Brassicae siccus 4 ~ 8 parts, Herba Orchidis Latifoliae 7 ~ 11 parts, Arisaema intermedium Blume 2 ~ 6 parts, ceriander seed 6 ~ 10 parts.

As preferably of the present invention, it is made up of the crude drug of following weight portion: Flos Pruni mume 40 parts, Fructus Akebiae 20 parts, Polygonum cynanchoides Hemsl. 30 parts, 20 parts, rattan wingceltis, tiger 7 12 parts, Folium clausenae lansii 10 parts, Herba Peperomiae Dindygulensis 10 parts, flat bamboo survey 18 parts, Herba Hylotelephii Mingjiniani 22 parts, Radix Caraganae Sinicae 16 parts, Herba Hyperici Sampsonii 18 parts, Folium Craibiodendri Yunnanensis 10 parts, pleionebulbocodioides rolfe 12 parts, Bulbus Allii Victorialis 16 parts, horse Radix Salicis Babylonicae 10 parts, Flos Momordicae Charantiae 9 parts, Pericarpium syzygii 9 parts, Salted Brassicae siccus 6 parts, Herba Orchidis Latifoliae 9 parts, Arisaema intermedium Blume 4 parts, ceriander seed 8 parts.

Preferably, the preparation method of Chinese medicine composition of the present invention, it is prepared from by with following processing step:

(1) get Polygonum cynanchoides Hemsl., horse Radix Salicis Babylonicae is ground into 100 object fine powders, for subsequent use;

(2) get Flos Pruni mume, Fructus Akebiae, rattan wingceltis, tiger seven, Folium clausenae lansii, Herba Peperomiae Dindygulensis, the survey of flat bamboo, Herba Hylotelephii Mingjiniani, Radix Caraganae Sinicae, Herba Hyperici Sampsonii, Folium Craibiodendri Yunnanensis, pleionebulbocodioides rolfe, Bulbus Allii Victorialis, Flos Momordicae Charantiae, Pericarpium syzygii, Salted Brassicae siccus, Herba Orchidis Latifoliae, Arisaema intermedium Blume, ceriander seed medical material again, decoct with water 2 times, it is the water of 10 times amount that first time adds with medical material weight ratio, decoct 1h, filter; It is the water of 7 times amount that second time adds with medical material weight ratio, decoct 0.5h, filter, merge 2 filtrates, filtrate is concentrated into the extractum of relative density 1.20 ~ 1.30, add again above-mentioned steps (1) in fine powder for subsequent use, carry out drying under reduced pressure and become dry cream, pulverize, sieve, obtain, the active component of Chinese medicine composition of the present invention.

The active component of Chinese medicine composition of the present invention can add the adjuvant of the various routines prepared needed for different dosage form, as disintegrating agent, lubricant, filler, binding agent etc. are prepared into the conventional peroral dosage form of any one, as granule, tablet, hard capsule etc. with the Chinese medicine composition method of routine.

The present invention is under Traditional Chinese medical theory and clinical experience instruct, and through dialectical compatibility, chooses each crude drug component and proportioning thereof.Its each medical material compatibility complements each other using, and has synergism.Integrally-regulated function can be reached, to adapt to the treatment requirement of the complicated state of an illness, and improve the clinical efficacy of full side.Make full side have dispersing the stagnated liver-QI for regulating the stomach, regulating QI to relieve pain, promoting blood circulation to remove blood stasis, soothing the liverly to expel the heat-evil, warming middle-JIAO and strengthening the spleen, yin nourishing stomach function regulating effect.Through clinical verification, the effective percentage of the clinical cure of Chinese medicine composition of the present invention reaches 98.5%.Clinical and pharmacological experiment study confirms all, and traditional Chinese medicine composition for treating gastric ulcer determined curative effect of the present invention, can protect gastric mucosa, promotes ulcer healing, reduces gastric acid secretion, has overall clinical efficacy rate high, have no side effect, the feature that relapse rate is low.And the preparation technology of Chinese medicine composition of the present invention is simple, cost is low, has good market application foreground.

Set forth the beneficial effect of Chinese medicine composition of the present invention further below by way of test example, these test examples include pharmacology test and the clinical observation on the therapeutic effect test of Chinese medicine composition of the present invention.

Pharmacological testing: the experimentation to gastric ulcer of Chinese medicine composition of the present invention

1 test material and result processing method:

1.1 medicines and reagent: Weikang capsule for curing gastric disease: (Guangxi Yulin Dajinda Pharmaceutical Co., Ltd.); Aspirin: (Shandong Xinhua Pharmaceutical Factory).

The preparation of 1.2 trial drugs:

1.2.1 the preparation of trial drug of the present invention:

(1) get Polygonum cynanchoides Hemsl. 30g, horse Radix Salicis Babylonicae 10g is ground into 100 object fine powders, for subsequent use;

(2) get Flos Pruni mume 40g, Fructus Akebiae 20g, rattan wingceltis 20g, tiger seven 12g, Folium clausenae lansii 10g, Herba Peperomiae Dindygulensis 10g, the survey of flat bamboo 18g, Herba Hylotelephii Mingjiniani 22g, Radix Caraganae Sinicae 16g, Herba Hyperici Sampsonii 18g, Folium Craibiodendri Yunnanensis 10g, pleionebulbocodioides rolfe 12g, Bulbus Allii Victorialis 16g, Flos Momordicae Charantiae 9g, Pericarpium syzygii 9g, Salted Brassicae siccus 6g, Herba Orchidis Latifoliae 9g, Arisaema intermedium Blume 4g, ceriander seed 8g again, decoct with water 2 times, it is the water of 10 times amount that first time adds with medical material weight ratio, decoct 1h, filter; It is the water of 7 times amount that second time adds with medical material weight ratio, decoct 0.5h, filter, merge 2 filtrates, filtrate is concentrated into the extractum of relative density 1.20 ~ 1.30, add again above-mentioned steps (1) in fine powder for subsequent use, carry out drying under reduced pressure and become dry cream, pulverize, sieve, obtain, the active component of Chinese medicine of the present invention.Before use, adding distil water is mixed with the concentration needed for experiment.

1.3 animal Kunming mouses: provided by Xi'an Medical University's Experimental Animal Center.

2 test methods and result:

2.1 impacts on mice stress gastric ulcer

Choose healthy Kunming mouse 30, male and female half and half, be divided into 3 groups at random, be respectively model group, Weikang capsule for curing gastric disease, Chinese medicine composition group of the present invention, each 10 groups.Every day gastric infusion 1 time, continuous 6 days.L hour after last administration, extremity, after 24 hours, are fixed in template by mice fasting, are soaked in 14 hours (spending the night) in 22 ~ 25 DEG C of water.Take out animal, put to death, dissect ligation stomach pylorus and cardia respectively, and gastric only injects 3% formalin 1ml/.After fixing 10 minutes, dissect the Area of ulcer in Microscopic observation glandular stomach portion.Result of the test is in table 1.

Table l compares (x ± s) mice stomach Area of ulcer

Experimental result from table 1: compared with model control group, Chinese medicine composition group of the present invention, Weikang capsule for curing gastric disease all obviously can reduce the Area of ulcer of mice stress gastric ulcer, and the Area of ulcer of Chinese medicine composition group of the present invention to mice stress gastric ulcer is better than Weikang capsule for curing gastric disease group.

2.2 impacts on Mouse Stomach liquid measure, total acidity gastric juice, pepsin activity

Choose healthy Kunming mouse 30, male and female half and half.Being divided into 3 groups at random, is model control group, Weikang capsule for curing gastric disease, Chinese medicine composition group of the present invention, ig administration 1 time every day, continuous 6 days.L hour after last administration, mice fasting 24 hours.Each treated animal is under pentobarbital sodium (50mg/kg, ip) anesthesia, and sterilization skin, cuts open the belly, ligation stomach pylorus, each group duodenal administration 1 (the same given low of dosage) skin suture afterwards respectively.Post operation 4 hours, then open abdomen extraction gastric juice, measurement volumes (ml), and the ml number that conversion is every 20g body weight.Get gastric juice titrimetry (using 0.01NNaOH titration, using phenolphthalein as indicator) and measure gastric acidity, measure pepsin activity with Mai Teshi capillary glass-tube method.Result of the test is in table 2.

The mensuration (n=10, x ± s) of table 2 pair Mouse Stomach liquid measure, total acidity gastric juice, pepsin activity

Result of the test 2 shows, Chinese medicine composition of the present invention can reduce Mouse Stomach liquid measure, total acidity gastric juice, pepsin activity, and effect is better than Weikang capsule for curing gastric disease group.

2.3 analgesic activity

Get Kunming mouse 30, male and female half and half, be divided into 3 groups at random, be i.e. model group, aspirin group, Chinese medicine composition group of the present invention, often organize 10.Gastric infusion volume is 0.2ml/10g, and model control group gives equal-volume distilled water.Continuous gastric infusion 7 days, after last administration 1 hour, each Mus lumbar injection 0.6% acetum 0.2ml/ only, and after 5 minutes, count the writhing response number of times of each Mus appearance in 10 minutes.Result of the test is in table 3.

The comparison (x ± s) of mouse writhing reaction times respectively organized by table 3

Result of the test 3 shows, compared with model control group, Chinese medicine composition of the present invention and aspirin group significantly can reduce the mouse writhing number of times that acetic acid causes.

In sum, Chinese medicine composition of the present invention has antiulcer, gastric acid inhibitory, gastric secretion and pepsin activity and analgesic activity, point out Chinese medicine composition of the present invention to have good therapeutical effect to gastric ulcer, embody herbal mixture and there is the synergistic Therapeutic Characteristics of globality, Mutiple Targets and multicomponent.Clinical practice for Chinese medicine composition of the present invention provides pharmacology's foundation.

Detailed description of the invention

Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.

The capsule preparation of embodiment 1 Chinese medicine composition of the present invention

(1) get Polygonum cynanchoides Hemsl. 30g, horse Radix Salicis Babylonicae 10g is ground into 100 object fine powders, for subsequent use;

(2) get Flos Pruni mume 40g, Fructus Akebiae 20g, rattan wingceltis 20g, tiger seven 12g, Folium clausenae lansii 10g, Herba Peperomiae Dindygulensis 10g, the survey of flat bamboo 18g, Herba Hylotelephii Mingjiniani 22g, Radix Caraganae Sinicae 16g, Herba Hyperici Sampsonii 18g, Folium Craibiodendri Yunnanensis 10g, pleionebulbocodioides rolfe 12g, Bulbus Allii Victorialis 16g, Flos Momordicae Charantiae 9g, Pericarpium syzygii 9g, Salted Brassicae siccus 6g, Herba Orchidis Latifoliae 9g, Arisaema intermedium Blume 4g, ceriander seed 8g again, decoct with water 2 times, it is the water of 10 times amount that first time adds with medical material weight ratio, decoct 1h, filter; It is the water of 7 times amount that second time adds with medical material weight ratio, decocts 0.5h, filters, merge 2 filtrates, filtrate is concentrated into the extractum of relative density 1.20 ~ 1.30, then add above-mentioned steps (1) in fine powder for subsequent use, carry out drying under reduced pressure and become dry cream, pulverize, sieve, to obtain final product, add suitable adjuvant, granulate, encapsulated, make hard capsule.

The granule preparation of embodiment 2 Chinese medicine composition of the present invention

(1) get Polygonum cynanchoides Hemsl. 32g, horse Radix Salicis Babylonicae 8g is ground into 100 object fine powders, for subsequent use;

(2) get Flos Pruni mume 42g, Fructus Akebiae 18g, rattan wingceltis 22g, tiger seven 10g, Folium clausenae lansii 8g, Herba Peperomiae Dindygulensis 12g, the survey of flat bamboo 20g, Herba Hylotelephii Mingjiniani 24g, Radix Caraganae Sinicae 18g, Herba Hyperici Sampsonii 16g, Folium Craibiodendri Yunnanensis 8g, pleionebulbocodioides rolfe 10g, Bulbus Allii Victorialis 18g, Flos Momordicae Charantiae 7g, Pericarpium syzygii 11g, Salted Brassicae siccus 8g, Herba Orchidis Latifoliae 11g, Arisaema intermedium Blume 6g, ceriander seed 6g again, decoct with water 2 times, it is the water of 10 times amount that first time adds with medical material weight ratio, decoct 1h, filter; It is the water of 7 times amount that second time adds with medical material weight ratio, decocts 0.5h, filters, merge 2 filtrates, filtrate is concentrated into the extractum of relative density 1.20 ~ 1.30, then add above-mentioned steps (1) in fine powder for subsequent use, carry out drying under reduced pressure and become dry cream, pulverize, sieve, obtain, with appropriate dextrin, sucrose, mixing, granulates, drying, makes granule.

The tablet preparation of embodiment 3 Chinese medicine composition of the present invention

(1) get Polygonum cynanchoides Hemsl. 28g, horse Radix Salicis Babylonicae 12g is ground into 100 object fine powders, for subsequent use;

(2) get Flos Pruni mume 38g, Fructus Akebiae 22g, rattan wingceltis 18g, tiger seven 14g, Folium clausenae lansii 12g, Herba Peperomiae Dindygulensis 8g, the survey of flat bamboo 16g, Herba Hylotelephii Mingjiniani 20g, Radix Caraganae Sinicae 14g, Herba Hyperici Sampsonii 20g, Folium Craibiodendri Yunnanensis 12g, pleionebulbocodioides rolfe 14g, Bulbus Allii Victorialis 14g, Flos Momordicae Charantiae 11g, Pericarpium syzygii 7g, Salted Brassicae siccus 4g, Herba Orchidis Latifoliae 7g, Arisaema intermedium Blume 2g, ceriander seed 10g again, decoct with water 2 times, it is the water of 10 times amount that first time adds with medical material weight ratio, decoct 1h, filter; It is the water of 7 times amount that second time adds with medical material weight ratio, decocts 0.5h, filters, merge 2 filtrates, filtrate is concentrated into the extractum of relative density 1.20 ~ 1.30, then add above-mentioned steps (1) in fine powder for subsequent use, carry out drying under reduced pressure and become dry cream, pulverize, sieve, to obtain final product, mix with appropriate amount of starch, dextrin, granulate, be pressed into tablet.

In order to verify the curative effect of finished product preparation of the present invention further, the finished capsule product agent medicine of preparation in above-mentioned specific embodiment 1 has been carried out corresponding clinical trial by us, existing that report the test is as follows.

The clinical observation to patients w ith peptic ulcer disease of Chinese medicine composition of the present invention

1. physical data

Accept patients w ith peptic ulcer disease totally 123 examples in June, 2012 ~ 2014 year October for medical treatment, with reference to the Gastric Ulcer standard in " the clinical disease for digest of Chinese and western medicine ".Make a definite diagnosis in conjunction with clinical manifestation and gastroscopy.Be divided into treatment group 65 example and matched group 58 example at random.24 ~ 70 years old treatment group age, year mean age (43.3 ± 2.5), the course of disease 8 months ~ 8 years, average course of disease (3.7 ± 0.8) year; Matched group, 26 ~ 68 years old age, year mean age (41.6 ± 3.1), the course of disease 6 months ~ 9 years, average course of disease (3.2 ± 0.9) year, through statistical procedures no significant difference (P > 0.05) between two groups of patient ages, the course of disease, severity extent, there is comparability.

2. diagnostic criteria

(1) all patients all have stomachache in various degree, belch, regurgitation, Nausea and vomiting, ballooning, thin white fur of tongue, deep pulse, pale complexion.(2) gastroscopy: visible stomach or duodenal site have hyperemia in various degree, edema and erosion under gastroscope, and ulcer spot has the fraction of some larks to ooze out.

3. Therapeutic Method

Matched group: give Weikang capsule for curing gastric disease (Guangxi Yulin Dajinda Pharmaceutical Co., Ltd.) oral medication, 3 tablets/time, 3 times/d.

Treatment group: capsule prepared by the oral embodiment of the present invention 1,3 tablets/time, 3 times/d.Two groups was all a course for the treatment of with 1 week, took continuously, 4 courses for the treatment of, and treatments period is stopped using other medicines, keep happy, diet should be light, avoids the irritable food such as acid, peppery, cigarette, wine, strong tea, the course for the treatment of terminates, further consultation after drug withdrawal January, and carries out electronic gastroscope check assessment curative effect.

4. efficacy assessment standard

Recovery from illness: patient clinical symptom disappears all completely, all disappears through gastroscopy stomach ulcer and surrounding inflammation; Effective: patient clinical symptom has remarkable alleviation, disappear through gastroscopy stomach ulcer, but still have inflammation; Effective: patient clinical symptom is alleviated to some extent, through gastroscopy stomach ulcer reduction face >50%; Invalid: clinical symptoms without how to improve or to increase the weight of, ulcer area reduction face <50%.

5. therapeutic outcome

5.1 liang of group patient clinical comparitive study the results are shown in Table 4.

Table 4 liang group patient clinical comparitive study

From the experimental result of table 4, through the treatment of 4 courses for the treatment of, most patient all has recovery in various degree, and the total effective rate of traditional Chinese medicine composition for treating group of the present invention is 98.5%, and the patient's effective percentage taking matched group (Weikang capsule for curing gastric disease) is only 70.7%.Result shows, the clinical efficacy of Chinese medicine composition of the present invention in treatment gastric ulcer is remarkable, is obviously better than matched group.

5.2 liang of group patients occur that untoward reaction and recurrence are in table 5 over the course for the treatment of.

Table 5 liang group adverse reactions of patients and recurrence compare

Above result shows, Chinese medicine composition of the present invention is safe and effective, and have no adverse reaction the advantage low with relapse rate.In sum, illustrate that Chinese medicine composition of the present invention has obvious clinical effectiveness to gastric ulcer, be worth applying clinically and promoting.

6. model case

Case 1, often certain, female, 44 years old, gastropathy history more than 1 year, because diet was irregular all the year round, cause stomach discomfort, once in a while with pain, cardinal symptom is epigastric discomfort, belch, acid regurgitation, big belly, Nausea and vomiting, poor appetite, is light moderate gastric ulcer after diagnosing, after taking 4 courses for the treatment of of Chinese medicine composition of the present invention, transference cure, is almost recovered, and to have no side effect appearance at period in a medicine.

Case 2, high certain, man, 36 years old, gastropathy history more than 4 years, because long-time excessive drinking causes stomach discomfort, cardinal symptom: upper abdominal pain, dyspepsia, belch, acid regurgitation, Nausea and vomiting, be moderate gastric ulcer after diagnosing, after taking 1 course for the treatment of of Chinese medicine composition of the present invention, symptom fades away, and have no side effect during medication appearance, fully recover after continuing to take 3 courses for the treatment of, without recurrence in 1 year.

Case 3, Wu, female, 30 years old, gastropathy history more than 2 years, patient because of the fatigue that works, pressure comparatively large, and vinegar-pepper raw food liked by diet, often the twinge of sensation gastral cavilty, abdominal distention, belch, feel sick, and health is comparatively become thin.To our hospital afterwards, after taking 4 courses for the treatment of of Chinese medicine composition of the present invention, stomachache is not reaccessed, and abdominal distention, belch, nausea disappear, and body weight increases than before, fully recovers through gastroscopy gastric ulcer.

Case 4, Lee, man, 54 years old, gastropathy history more than 7 years, the swollen pain of normal sense chest tightness was gastric ulcer in local gastroscopy.After 2 courses for the treatment of of Chinese medicine composition of the present invention, Upper abdominal pain and the swollen blocking sense of chest tightness alleviate, and after continuing to take 2 courses for the treatment of of Chinese medicine composition of the present invention, gastroscope is checked, and atrophic gastritis disappears, and each side is good, and physical condition is all thoroughly improved.

Case 5, in certain, female, 63 years old, more than gastropathy history August, often occur suffering from abdominal pain, the symptom of abdominal distention, take the medicines such as stomach peace capsule, long-term taking produces drug resistance, and curative effect of medication is not very desirable, often recurs later.After taking 1 course for the treatment of of Chinese medicine composition of the present invention, abdominal distention, abdomen pain disappears, and appetite increases to some extent.After continuing to take 2 courses for the treatment of, other clinical symptoms disappear substantially, and body weight increases, and after continuing to strengthen again 1 course for the treatment of, all symptoms all thoroughly disappear, and drug withdrawal is so far again without repeatedly.

Claims (4)

1. treat the Chinese medicine composition of gastric ulcer for one kind, it is characterized in that, it is made up of the crude drug of following weight portion: Flos Pruni mume 38 ~ 42 parts, Fructus Akebiae 18 ~ 22 parts, Polygonum cynanchoides Hemsl. 28 ~ 32 parts, 18 ~ 22 parts, rattan wingceltis, tiger 7 10 ~ 14 parts, Folium clausenae lansii 8 ~ 12 parts, Herba Peperomiae Dindygulensis 8 ~ 12 parts, flat bamboo surveys 16 ~ 20 parts, Herba Hylotelephii Mingjiniani 20 ~ 24 parts, Radix Caraganae Sinicae 14 ~ 18 parts, Herba Hyperici Sampsonii 16 ~ 20 parts, Folium Craibiodendri Yunnanensis 8 ~ 12 parts, pleionebulbocodioides rolfe 8 ~ 12 parts, Bulbus Allii Victorialis 14 ~ 18 parts, horse Radix Salicis Babylonicae 8 ~ 12 parts, Flos Momordicae Charantiae 7 ~ 11 parts, Pericarpium syzygii 7 ~ 11 parts, Salted Brassicae siccus 4 ~ 8 parts, Herba Orchidis Latifoliae 7 ~ 11 parts, Arisaema intermedium Blume 2 ~ 6 parts, ceriander seed 6 ~ 10 parts.

2. Chinese medicine composition as claimed in claim 1, it is characterized in that, it is made up of the crude drug of following weight portion: Flos Pruni mume 40 parts, Fructus Akebiae 20 parts, Polygonum cynanchoides Hemsl. 30 parts, 20 parts, rattan wingceltis, tiger 7 12 parts, Folium clausenae lansii 10 parts, Herba Peperomiae Dindygulensis 10 parts, flat bamboo survey 18 parts, Herba Hylotelephii Mingjiniani 22 parts, Radix Caraganae Sinicae 16 parts, Herba Hyperici Sampsonii 18 parts, Folium Craibiodendri Yunnanensis 10 parts, pleionebulbocodioides rolfe 12 parts, Bulbus Allii Victorialis 16 parts, horse Radix Salicis Babylonicae 10 parts, Flos Momordicae Charantiae 9 parts, Pericarpium syzygii 9 parts, Salted Brassicae siccus 6 parts, Herba Orchidis Latifoliae 9 parts, Arisaema intermedium Blume 4 parts, ceriander seed 8 parts.

3. the preparation method of Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, it is made up of following step:

(1) get Polygonum cynanchoides Hemsl., horse Radix Salicis Babylonicae is ground into 100 object fine powders, for subsequent use;

(2) get Flos Pruni mume, Fructus Akebiae, rattan wingceltis, tiger seven, Folium clausenae lansii, Herba Peperomiae Dindygulensis, the survey of flat bamboo, Herba Hylotelephii Mingjiniani, Radix Caraganae Sinicae, Herba Hyperici Sampsonii, Folium Craibiodendri Yunnanensis, pleionebulbocodioides rolfe, Bulbus Allii Victorialis, Flos Momordicae Charantiae, Pericarpium syzygii, Salted Brassicae siccus, Herba Orchidis Latifoliae, Arisaema intermedium Blume, ceriander seed medical material again, decoct with water 2 times, it is the water of 10 times amount that first time adds with medical material weight ratio, decoct 1h, filter; It is the water of 7 times amount that second time adds with medical material weight ratio, decoct 0.5h, filter, merge 2 filtrates, filtrate is concentrated into the extractum of relative density 1.20 ~ 1.30, add again above-mentioned steps (1) in fine powder for subsequent use, carry out drying under reduced pressure and become dry cream, pulverize, sieve, obtain, the active component of Chinese medicine composition of the present invention.

4. the application of Chinese medicine composition as claimed in claim 1 or 2 in preparation treatment Gastric Ulcer Treatment.