CN104758422B - Chinese medicine ultrasonic coupling paster - Google Patents
Chinese medicine ultrasonic coupling paster Download PDFInfo
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- CN104758422B CN104758422B CN201510150126.1A CN201510150126A CN104758422B CN 104758422 B CN104758422 B CN 104758422B CN 201510150126 A CN201510150126 A CN 201510150126A CN 104758422 B CN104758422 B CN 104758422B
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Abstract
A kind of Chinese medicine ultrasonic coupling paster of the present invention, there is provided a kind of medicinal material extract rate is high, and liquor strength is high, and impurity is few, and cutaneous penetration effect is good and designs.Chinese medicine ultrasonic coupling paster of the present invention, include the raw material of following parts by weight：Rheum officinale 90~140；The dried immature fruit of citron orange 100~150；The bark of official magnolia 120~180；Saltcake 60~130；Radish seed 70~140.The active ingredient that the present invention extracts is more comprehensive, and the recovery rate of medicine is high, and the combination of penetrating agent utilizes so that targeting cutaneous penetration clinical effectiveness is more preferable, and massively technical support is provided clinically more to widely use.
Description
Technical field
The present invention relates to a kind of Chinese medicine ultrasonic coupling paster.
Background technology
Ultrasound-transdermal target administration technology enters China in 2009, due to clinically most early in the extensive clinical practice in the U.S.
Positive effect, the toxic side effect of medicine is greatly reduced, simple to operate, no pain, safely and effectively, is connect quickly by doctor patient
By being formally classified as within 2010 national medical insurance charge.On the basis of phonophoresis, if can start with pharmaceutical preparation,
The drug molecule of preparation is set to be easier transdermal cuticula, so, under same ultrasound condition, drugs through skin is got over
More, clinical therapeutic efficacy is better.Now, the research of the transdermal needs of pharmaceutical preparation adaptation is few, so, it is of the invention from medicine
Extraction process, the recovery rate of each composition, the composite factor such as destruction situation, the purifying of extract component of each composition in extraction process
Further investigation, makes the Chinese medicine ultrasonic coupling paster for being more suitable for cutaneous penetration.Meanwhile in the selection of penetrating agent, also carry out
Substantial amounts of research, an optimal penetrating agent combination is eventually found, tests prove that, there is obvious rush to ooze to most of medicine
Effect.
The content of the invention
In view of the above-mentioned problems, the present invention provides, a kind of clinical application effect is good, and cost is low, Chinese medicine ultrasound coupling easy to make
Close paster.
To achieve the above object of the invention, Chinese medicine ultrasonic coupling paster of the present invention, including following raw material：Rheum officinale, the dried immature fruit of citron orange, thickness
Piao, saltcake, radish seed.
Specifically, described Chinese medicine ultrasonic coupling paster includes the raw material of following parts by weight：
Further, the preparation technology of described Chinese medicine ultrasonic coupling paster comprises at least：
The water of yellow 4~8 times of weight is increased in S1 rheum officinales, is soaked 30 minutes~1.5 hours, is heated to seething with excitement, continues 5 minutes
~60 minutes, filtering, obtain rheum officinale filter residue；
S2 rheum officinales filter residue, the dried immature fruit of citron orange, the bark of official magnolia, radish seed add described rheum officinale filter residue, the dried immature fruit of citron orange, the bark of official magnolia, radish seed gross weight 5~
12 times of water, soak 40 minutes~3 hours, be heated to seething with excitement, continue 50 minutes~2.5 hours, filter, filter residue is obtained, to institute
Add the water of 4~9 times of filter residue weight in the filter residue stated, ebuillition of heated, continue 30 minutes~2 hours, filter, will be filtrated to get twice
Filtrate merge；
By S2 merging filtrate, 40 DEG C~80 DEG C are concentrated under reduced pressure S3, vacuum -0.09MP~-0.06MP, are concentrated into 1/7
~1/4, obtain concentrate；
S4 adds S3 concentrate 95% ethanol, and stirring is equal, allows concentration of alcohol to reach 30%~70%, stands 12
~36 hours, filtering, collect supernatant；
S4 supernatant is carried out ethanol recovery, temperature 60 C, vacuum -0.09MP~-0.06MP, until without alcohol by S5
Taste；
S5 supernatant is continued to concentrate by S6, and 40 DEG C~80 DEG C are concentrated under reduced pressure, vacuum -0.09MP~-0.06MP, concentration
To 1/5~1/2 volume, merge with the big yellow filtrate that S1 is obtained, mix, obtain decoction；
Saltcake is added in above-mentioned S6 mixed solution by S7, stirring, until dissolving.Obtain decoction.
Further, the weight ratio of the penetrating agent is：Azone 0.5%~4%, ethanol 12%~35%, propane diols
0.8%~12%；Addition sequence is：First azone and ethanol are well mixed, is added in S7 solution, it is molten to add propane diols
Liquid, stir.
Further, the preparation technology of described Chinese medicine ultrasonic coupling paster also includes：Paster is immersed in described medicine
In liquid, it is impregnated with, picks up, centrifuge 1~5 minute, rotating speed 50~400r per minute.Each paster drugloading rate 2g ± 0.2.
Beneficial effect：
Compared with existing correlation technique, Chinese medicine ultrasonic coupling paster of the present invention at least has the advantages that：
First, the uniqueness of formula.Rheum officinale purgating heat and bowels in side, cleanses stomach, is monarch drug in a prescription.Saltcake helps rheum officinale purgating heat and bowels,
And energy softening mass and moistening dryness, it is ministerial drug；The bark of official magnolia, dried immature fruit of citron orange promoting the circulation of qi dissipating bind, relieving distension and oppression, radish seed promoting the circulation of qi dissipate-swelling, three medicines make a concerted effort to help nitre, Huang
Push away to swing and stagnate to accelerate the excretion of thermojunction, make altogether for assistant；Enterogastric peristalsis can be promoted entirely, accelerate postoperative bowel.
Second, the technique of extraction it is scientific and reasonable, mainly for rheum officinale, stage extraction, improve each composition as far as possible
Recovery rate, reduce the destruction to each composition as far as possible, retain all active ingredients in rheum officinale, to ensure its clinical effectiveness.
3rd, the combination of penetrating agent utilizes, and makes drug transdermal effect more preferable, and target administration effect is good, for clinically more
Widely use and provide massively technical support.
4th, medicinal material extract rate is high, and liquor strength is high, and impurity is few, and osmotic effect is good, and ethanol can recycle and reuse, both
Crude drug and the energy have been saved, has improved liquor strength again.
Embodiment
With reference to specification, the present invention will be further described.
Embodiment one
The present embodiment Chinese medicine ultrasonic coupling paster, include the raw material of following parts by weight：
Embodiment two
The present embodiment Chinese medicine ultrasonic coupling paster, include the raw material of following parts by weight：
Embodiment three
The present embodiment Chinese medicine ultrasonic coupling paster, include the raw material of following parts by weight：
Example IV
The present embodiment Chinese medicine ultrasonic coupling paster, include the raw material of following parts by weight：
Embodiment five
The present embodiment Chinese medicine ultrasonic coupling paster, include the raw material of following parts by weight：
Embodiment six
The present embodiment Chinese medicine ultrasonic coupling paster, include the raw material of following parts by weight：
Embodiment seven
The present embodiment Chinese medicine ultrasonic coupling paster, include the raw material of following parts by weight：
Embodiment eight
The present embodiment Chinese medicine ultrasonic coupling paster, include the raw material of following parts by weight：
In the various embodiments described above, the preparation technology of described Chinese medicine ultrasonic coupling paster comprises at least：
The water of yellow 4~8 times of weight is increased in S1 rheum officinales, is soaked 30 minutes~1.5 hours, is heated to seething with excitement, continues 5 minutes
~60 minutes, filtering, obtain rheum officinale filter residue；
S2 rheum officinales filter residue, the dried immature fruit of citron orange, the bark of official magnolia, radish seed add described rheum officinale filter residue, the dried immature fruit of citron orange, the bark of official magnolia, radish seed gross weight 5~
12 times of water, soak 40 minutes~3 hours, be heated to seething with excitement, continue 50 minutes~2.5 hours, filter, filter residue is obtained, to institute
Add the water of 4~9 times of filter residue weight in the filter residue stated, ebuillition of heated, continue 30 minutes~2 hours, filter, will be filtrated to get twice
Filtrate merge；
By S2 merging filtrate, 40 DEG C~80 DEG C are concentrated under reduced pressure S3, vacuum -0.09MP~-0.06MP, are concentrated into 1/7
~1/4, obtain concentrate；
S4 adds S3 concentrate 95% ethanol, and stirring is equal, allows concentration of alcohol to reach 30%~70%, stands 12
~36 hours, filtering, collect supernatant；
S4 supernatant is carried out ethanol recovery, temperature 60 C, vacuum -0.09MP~-0.06MP, until without alcohol taste by S5
(being obtained by detection)；
S5 supernatant is continued to concentrate by S6, and 40 DEG C~80 DEG C are concentrated under reduced pressure, vacuum -0.09MP~-0.06MP, concentration
To 1/5~1/2 volume, merge with the big yellow filtrate that S1 is obtained, mix, obtain decoction；
Saltcake is added in above-mentioned S6 mixed solution by S7, stirring, until dissolving.Obtain decoction.
Further, the preparation technology of described Chinese medicine ultrasonic coupling paster also includes：Paster is immersed in described medicine
In liquid, it is impregnated with, picks up, centrifuge 1~5 minute, rotating speed 50~400r per minute.Each paster drugloading rate 2g ± 0.2.
First, the present invention is described further with reference to clinical practice example.
Influence research of the present invention to postoperative patients after undergoing abdominal operation intestinal function recovery
1.1 object and method
Object：96 (exclusion heart and lung diseases) Patients Undergoing Abdominal Surgeries between in October, -2014 in May, 2013 are randomly divided into
Treatment group and each 48 of control group.Treatment group 48, man 28, female 20 are 19 years old~76 years old age, average 51 years old.Control group
48, man 25, female 23,16 years old~74 years old age, average age 50 years old.Two groups of patient ages, gender differences are without statistics
Meaning, it is shown in Table 1 using general anesthesia, other surgery informations.
The abdominal operation species of table 1 counts
1.2 experimental results are shown in Table 2
2 two groups of micturition times of table and abdominal distension situation compare
1.3 interpretation of result
Patients Undergoing Abdominal Surgery is because preoperative taboo diet, INTESTINAL CLEANSING reduce gastro-intestinal secretion, and anaesthetic should in art
With, the drawing of operation, in art, enteron aisle open-assembly time is long, heat distribute causes gastrointestinal dysfunction, and it is compacted to show as intestines and stomach
It is dynamic to weaken or disappear, extend micturition time.This group of patients abdomen is postoperative because using ultrasonic conductance medicine technology by ultrasonic coupling
The saturating human gastrointestinal tract of paster is closed, the purpose is to directly act on intestines and stomach, is being partially formed high drug concentration area, the prescriptions of traditional Chinese medicine
Active ingredient can promote gastric juice and solid emptying, can improve blood plasma WeiDongLi Capsule element and put down, the work of enhancing Stomach duodenum activity
With, be advantageous to improve gastrointestinal dysfunction, promote passage of gas by anus, mitigate abdominal distension, reduce abdominal wound tension force, be advantageous to wound and be cured
Close.Postoperative anal exhaust is that the important of gastrointestinal peristalsis functional rehabilitation is accused of, and is that patient recovers postoperative feed function, smoothly tides over hand
The key of art phase.
This result of study shows, this prescription drug of abdominal postoperative Ultrasonic penetration can promote the extensive of enterocinesia and gastrointestinal function
It is multiple, be advantageous to passage of gas by anus, reduce the recurrence rate of abdominal distension.And this prescription cutaneous penetration, rapid-action, short treating period, to patient without
Wound, side reaction are small, are easily received by numerous patients, while also mitigate the incidence of postoperative abdominal distention.
2nd, application of the present invention in the postoperative function of intestinal canal of rectal cancer patient recovers
2.1 clinical data
This group shares primary postoperative rectal cancer patient 172, man 98, female 74；23~81 years old age, average 52.3
Year.It is randomly divided into observation group and each 86 of control group.Observation group man 51, female 35.Control group man 47, female 39.Two groups
Patient's general information comparing difference is not statistically significant (P ＞ 0.05), and all data gather by same seminar is unified, and
Information is filed, arrange, analyzed, research terminal is recovery from illness.
2.2 method
Control group：Implement conventional therapy and nursing.Observation group：Implement conventional therapy, nursing combines that ultrasonic conductance is transdermal gives
Medicine (Chinese medicine ultrasonic coupling paster).Concrete operation method：The postoperative clinostatism of making even of patient, Chinese medicine patch is placed in colon descendens belly body
Exterior portion position, carry out medicine using ultrasonic medicinal introducing apparatus and lead people, postoperative 2nd day starts to treat, each 30min, 2 times/d, treatment
Chinese medicine patch retains 2 hours after end, each course for the treatment of 3 days.
2.3 two groups of post-operative recovery situations are relatively shown in Table 3.
The post-operative recovery situation of table 3 compares
2.4 conclusion
Rectal cancer patient is postoperative due to the shadow of the factor such as anesthesia, operation wound, Water-Electrolyte is unbalance, abdominal cavity infection, bleeding
Ring, gastrointestinal function is caused gastrointestinal peristalsis to weaken and disappear by different degrees of suppression, abdominal distension, gurgling sound disappearance etc. is occurred
Symptom, and organismic internal environment disorder may be further resulted in and induce various complication, such as postoperative intestinal adhesion, intestinal obstruction.This
Research is promoted gastrointestinal peristalsis, increase intestines and stomach volume, is improved enteron aisle blood using ultrasound-transdermal administration (Chinese medicine ultrasonic coupling paster)
Liquid circulation, enteron aisle capillary permeability is reduced, patient's recovery situation is significantly better than control group, and this drug paste has clinical effect well
Fruit.
To the present invention it should be appreciated that embodiment described above, to the purpose of the present invention, technical scheme and beneficial to effect
Fruit has carried out further details of explanation, these are only embodiments of the invention, is not intended to limit the present invention, it is every
Within the spiritual principles of the present invention, made any modification, equivalent substitution and improvements etc., the protection of the present invention should be included in
Within the scope of, protection scope of the present invention should be defined by the protection domain that claim is defined.
Claims (1)
1. a kind of Chinese medicine ultrasonic coupling paster, it is characterised in that bulk drug and its parts by weight are：
The preparation technology of described Chinese medicine ultrasonic coupling paster comprises at least：
The water of yellow 4~8 times of weight is increased in S1 rheum officinales, is soaked 30 minutes~1.5 hours, is heated to seething with excitement, continues 5 minutes~60
Minute, filtering, obtain rheum officinale filter residue；
S2 rheum officinales filter residue, the dried immature fruit of citron orange, the bark of official magnolia, radish seed add described rheum officinale filter residue, the dried immature fruit of citron orange, the bark of official magnolia, 5~12 times of radish seed gross weight
Water, soak 40 minutes~3 hours, be heated to seething with excitement, continue 50 minutes~2.5 hours, filter, obtain filter residue, to described
Add the water of 4~9 times of filter residue weight in filter residue, ebuillition of heated, continue 30 minutes~2 hours, filter, the filter that will be filtrated to get twice
Liquid merges；
By S2 merging filtrate, 40 DEG C~80 DEG C are concentrated under reduced pressure S3, vacuum -0.09MP~-0.06MP, are concentrated into 1/7~1/
4, obtain concentrate；
S4 adds S3 concentrate 95% ethanol, stirs, and allows concentration of alcohol to reach 30%~70%, stands 12~36
Hour, filtering, collect supernatant；
S4 supernatant is carried out ethanol recovery, temperature 60 C, vacuum -0.09MP~-0.06MP, until without alcohol taste by S5；
S4 supernatant is continued to concentrate by S6, and 40 DEG C~80 DEG C are concentrated under reduced pressure, and vacuum -0.09MP~-0.06MP, are concentrated into 1/
5~1/2 volumes, merge with the big yellow filtrate that S1 is obtained, mix, obtain decoction；
Saltcake is added in above-mentioned S6 mixed solution by S7, stirring, until dissolving, obtains decoction；
S8 also includes penetrating agent, wherein the penetrating agent is azone, ethanol, propane diols, the weight ratio of the penetrating agent is：Azone
0.5%~4%, ethanol 12%~35%, propane diols 0.8%~12%；Addition sequence is：First azone and ethanol are mixed equal
It is even, it is added in S7 solution, adds propylene glycol solution, stir, obtains decoction；
The preparation technology of described Chinese medicine ultrasonic coupling paster also includes：Paster is immersed in the decoction that S8 is obtained, be impregnated with, dragged for
Rise, centrifuge 1~5 minute, rotating speed 50~400r per minute, each paster drugloading rate 2g ± 0.2.
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435264A (en) * | 2014-11-14 | 2015-03-25 | 陈绍娟 | Medicine for treating intestine obstruction |
| CN108836952A (en) * | 2018-07-06 | 2018-11-20 | 辽宁钰航生物医疗科技有限公司 | A kind of gel film and preparation method and high with the gel film promote to seep electrode patch |
| CN112641845A (en) * | 2021-01-18 | 2021-04-13 | 广州中医药大学第一附属医院 | Traditional Chinese medicine composition for relieving distension and relaxing bowels and preparation method and application thereof |
| CN113209205A (en) * | 2021-06-18 | 2021-08-06 | 上海市第七人民医院(上海中医药大学附属第七人民医院) | Traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction and preparation method thereof |
| CN117298193A (en) * | 2023-11-17 | 2023-12-29 | 长春中医药大学 | Traditional Chinese medicine composition for improving constipation by reversing intestinal flora structure and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846790A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation process of integration-type novel formulation of DACHENGQI decoction and a production method thereof |
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2015
- 2015-04-01 CN CN201510150126.1A patent/CN104758422B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846790A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation process of integration-type novel formulation of DACHENGQI decoction and a production method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 天枢穴超声电导透皮给药对腹部手术后胃肠蠕动恢复的影响;林婉冰;《中国中医药科技》;20140731;第21卷(第4期);第421、423页 * |
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