CN107875370B

CN107875370B - Traditional Chinese medicine composition for promoting enterokinesia to exhaust and preventing intestinal adhesion and preparation method thereof

Info

Publication number: CN107875370B
Application number: CN201711378218.0A
Authority: CN
Inventors: 詹章毅; 党瑞华
Original assignee: Shenzhen Jian An Pharmaceutical Ltd
Current assignee: Shenzhen Jian An Pharmaceutical Ltd
Priority date: 2017-12-19
Filing date: 2017-12-19
Publication date: 2020-12-29
Anticipated expiration: 2037-12-19
Also published as: CN107875370A

Abstract

The invention relates to a traditional Chinese medicine composition for promoting enterokinesia to exhaust and preventing intestinal adhesion and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw material components: 6-10 parts of Sichuan pepper, 10-15 parts of dried ginger, 6-10 parts of ginseng and 20-30 parts of maltose. The preparation method comprises the following steps: mixing the raw material components, and then uniformly mixing the raw material components with the matrix paste to obtain a paste; and uniformly coating the paste on the non-woven fabric of the back lining layer, and then pressing to obtain the emplastrum. The traditional Chinese medicine composition provided by the invention is prepared from pure traditional Chinese medicines, has no need of injection, no pain, good absorption, convenient use, exact curative effect, quick response, economy and practicality, can recover the intestinal function of a patient as early as possible, promote intestinal peristalsis and intestinal ventilation and prevent intestinal adhesion, and overcomes the defects of the existing clinical treatment technology; further, the patient can recover physical strength as early as possible, the wound healing is promoted, the number of hospitalization days is reduced, the family economic burden is lightened, the convenience is brought, and doctors and patients are greatly facilitated.

Description

Traditional Chinese medicine composition for promoting enterokinesia to exhaust and preventing intestinal adhesion and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for promoting enterokinesia to exhaust and preventing intestinal adhesion and a preparation method thereof.

Background

Medically, exsufflation is the hallmark of checking the success or failure of a surgical procedure. The exhaust indicates that the gastrointestinal motility has returned to normal, which is a signal to indicate that the patient can eat food. Clinically, the early exhaustion after operation is a key step directly related to the body recovery of the patients after operation, because the absorption of nutrition and the recovery of physique of the patients after operation mainly depend on the recuperation of diet.

The reason for the clinical delayed air exhaustion after surgical operation is as follows: first, surgical stimulation. During operation, the gastrointestinal tract function can be inhibited by intestinal canal exposure, direct stimulation of operation, mesenteric damage, stimulation of intraperitoneal inflammation, hypokalemia and the like, so that the postoperative intestinal peristalsis is weakened. Secondly, the intestinal peristalsis is reduced due to the influence of the anesthetic drugs. Thirdly, the normal peristalsis of the intestinal tract is inhibited due to surgical trauma. Fourthly, after operation, the patient can rest in bed for a long time due to pain, indwelling intubation and the like, and the activity is reduced. Fifthly, the abdominal belt is tied after the operation of the patient, so that the space occupied by the intestinal canal is reduced, and the peristalsis of the intestinal canal is restrained.

At present, the method for guiding patients to exhaust as soon as possible by doctors clinically mainly comprises the steps of advising the patients to turn over frequently when lying in bed, supporting the patients to move in the bed as early as possible, supplementing potassium after 24 hours of operation, containing anus with enema to exhaust the anal canal, and exhausting the abdominal part obviously by a method of intubating without exhausting; or the Zusanli acupoint is pinched with fingers to promote exhaust, the doctor advices on drinking lotus root starch, drinking radish soup and the like, the method has certain curative effect on promoting postoperative exhaust, but the exhaust time is more than 24-48 days, the nutrition intake of patients during the period of no exhaust is supplemented by adopting an infusion method, the burdens of unbalanced nutrition intake, delayed wound healing, prolonged hospitalization time, increased expense and the like are brought due to the incapability of eating, and particularly, the method is unforgettable for middle-aged and old patients who can not take water after cardiac insufficiency, severe infection, high fever and extremely weak cerebral apoplexy; clinically, patients with advanced surgery are not few, but the patients are difficult to improve intestinal ventilation and take medicine after surgery, and particularly, decoction is easy to cause digestive tract symptoms such as nausea and vomiting, and medicine granules are difficult to swallow, and other dosage form problems need to be improved. The non-compliance of the dosage form is one of the problems, and the enhancement of the curative effect and the convenient use are two major requirements for postoperative patients. Therefore, the air exhaust time of the postoperative patient is shortened, the intestinal peristalsis is promoted to ventilate at the earliest time, and the patient can drink and eat water in a practical clinical meaning.

The Jianzhong decoction is used as a basic formula for treating deficiency-cold diseases mainly including gastrointestinal motility disorder and the like after surgery, and can achieve certain curative effect on orthopedic patients suffering from symptoms of abdominal fullness and the like after long-term lying and patients subjected to lower gastrointestinal tract surgery regardless of deficiency and excess. Chronic gastritis, peptic ulcer, ulcerative colitis, abdominal swelling and swelling in abdominal visual examination of orthopedic patients, appendicitis evolving into rectal uterine abscess simple ileus, recurrent ileus, schizophrenia patients with frequent paralytic ileus, simple adhesive ileus, adhesive ileus patients with a history of digestive tract operations, intestinal peristalsis restlessness, peritonitis, pericecal inflammation, post-cesarean section and the like are all the indications.

The key points of pathogenesis are mainly deficiency-cold of spleen and stomach, the primary aim is to warm the middle and tonify deficiency, and the main guide is to build the middle and tonify deficiency and moderate and urgent the interior, so the plaster for oral administration and external use has the research and invention values in theory or practice.

After being taken orally, the Dajianzhong decoction plays a role by stimulating the choline excitable nerve and the 5-hydroxytryptamine nerve in the intestinal canal wall. The perfusion of capillary vessels to gastrointestinal tissues is increased by expanding mesenteric microvessels of a rat with a spleen yang deficiency model, so that the mesenteric microcirculation function of the rat is improved, and an obvious dose-effect relationship exists; the research also finds that the TXB2/6-Keto-PGFla regulation system in the rat with the spleen yang deficiency model is disordered, and the effects of contracting blood vessels and promoting platelet aggregation are weakened by reducing the TXB2 content in plasma; the 6-Keto-PGFl alpha content in the plasma is increased, so that the functions of relaxing blood vessels and inhibiting platelet aggregation are enhanced, and the microcirculation perfusion of the gastrointestinal system is improved.

The existing various preparations such as DAJIANZHONG decoction, JIANZHONG granule and the like have certain effect on promoting intestinal peristalsis, but need to be orally taken after gastrointestinal function of postoperative patients is recovered, so that the drinking and eating time of the patients is delayed, and particularly, postoperative treatment cannot be timely achieved for seriously ill patients, infants and old people who are difficult to take medicine.

Based on this, in order to overcome the defects of the existing clinical treatment technology, the product which has the effects of externally treating internal diseases, is simple and convenient in method and safe to use and can quickly promote enterokinesia and intestinal ventilation after operation is provided is especially important.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide a traditional Chinese medicine composition for promoting enterokinesia to exhaust and preventing intestinal adhesion and a preparation method thereof. The traditional Chinese medicine composition provided by the invention is prepared from pure traditional Chinese medicines, does not need injection, has no pain, is good in absorption, convenient to use, exact in curative effect, quick in effect taking, economical and practical. The traditional Chinese medicine composition is used for treating internal diseases by external application, has no side effect, can greatly meet and facilitate the urgent requirements of a clinician for recovering the intestinal function of a patient as soon as possible after operation, promoting intestinal peristalsis and intestinal ventilation and preventing intestinal adhesion, relieves the pain of patients who cannot take medicines and are difficult to take medicines, and overcomes the defects of the existing clinical treatment technology; and then make patient's food recovery physical power as early as possible, promote the healing of wound, reduce the number of days of being in hospital, alleviate family's economic burden, bring the facility to very big doctor and patient of facilitating.

In order to achieve the purpose, the invention provides the following technical scheme:

in a first aspect, the invention provides a traditional Chinese medicine composition for promoting intestinal peristalsis, which comprises the following raw material components in parts by weight: 6-10 parts of Sichuan pepper, 10-15 parts of dried ginger, 6-10 parts of ginseng and 20-30 parts of maltose.

And (3) pepper: pungent, numb and warm in flavor, entering heart, spleen and kidney meridians. Daxingdan, pungent and hot in property, enter lung to dispel cold, enter spleen to warm stomach, warm middle energizer to dispel cold to relieve arthralgia, descend adverse qi to relieve pain, enter kidney to help fire, dispel cold to relieve pain, descend qi to dissipate stagnation, and is the monarch drug. Pharmacological research: fructus Zanthoxyli has antibacterial, platelet aggregation inhibiting and antioxidant effects, and contains volatile oil (terpenes linalool and limonene), alkaloid, amide, coumarin, flavonoid, fatty acid, sterol, lignin, etc. Dried ginger: the medicine has the effects of pungent and spicy qi and flavor, warmness, spleen, stomach, kidney, heart and lung channels, pungent and hot dried ginger for dredging the heart, warming the middle-jiao for dispelling cold, supporting yang for dispelling cold and dispelling adverse qi, and fructus zanthoxyli for dispelling cold and warming the spleen to directly reach the spleen and stomach, and also has the effects of calming adverse-rising energy and preventing vomiting, and is a ministerial medicine; pharmacological research shows that the main effective components of rhizoma Zingiberis include volatile oil (alkene and terpenoid) and gingerol (6-gingerol) with analgesic and anti-inflammatory effects, and non-volatile components such as beta-sitosterol, daucosterol, palmitic acid, and cyclosuccinic anhydride. Pharmacological research proves that the dried ginger has the effects of relieving pain and diminishing inflammation, resisting bacteria, relieving diarrhea, resisting tumors, resisting anoxia, improving local blood circulation and the like. The combination of Shu jiao and gan Jiang can relieve pain by dispelling cold pathogen and vomiting by descending turbid yin. Maltose: sweet in nature, warm in flavor, entering spleen, stomach and lung meridians. The traditional Chinese medicine is slightly warm, sweet and mild, warms and tonifies deficiency in middle-jiao, sweet can tonify spleen soil, relieves spasm and pain, helps the pricklyash peel to relieve pain, and simultaneously can alleviate dryness and intensity of pricklyash peel and dried ginger, and is used as a ministerial medicine; mainly contains maltose, vitamin B, iron, etc. Can be used for treating peptic ulcer and intestinal spasm. Ginseng: sweet, slightly bitter and warm in flavor, and enter spleen, lung, heart and kidney meridians. It is an adjuvant drug for tonifying spleen and lung qi, invigorating spleen and qi, and promoting the regeneration of middle-jiao with maltose to achieve the effect of invigorating qi and promoting yang. So long as it contains bioactive components such as ginsenoside (Rg1, Re, Rb1), ginseng polysaccharide, ginseng protein, etc. It has appetite stimulating, heart tonifying, antifatigue, antiaging, and antitumor effects, and can be used for treating anemia and neurasthenia.

According to the holistic concept and the principle of treatment based on syndrome differentiation and the basic pathophysiological characteristics after operation, the etiology is that the physiological functions of viscera are affected due to operation and anesthetic, so that the spleen and stomach rise and fall are abnormal, the transportation and transformation function is disordered, the promotion is weak, and the stagnation is obstructed. The gastrointestinal motility, secretion, digestion and absorption are disordered, and the normal gastrointestinal peristalsis and the gas and excrement discharge can not be carried out. The traditional Chinese medicine considers that the spleen and the stomach are the acquired root and the source of qi and blood generation, and the stomach and the intestine are used for the general purpose and the descending is the smooth. After operation, when the patient can not eat food, the patient needs to warm and dredge qi activities of internal organs to recover the gastrointestinal lifting function, and the medicine is administrated from navel to exert the double-overlapping treatment effects of percutaneous absorption of the medicine and dredging of channels, collaterals and internal organs by acupuncture points, so that the normal functions of the spleen and the stomach are aroused as early as possible. The four medicines are combined, the pricklyash peel is pungent and hot, enters the spleen and warms the stomach, warms the middle-jiao to dispel cold and dispel arthralgia, lowers adverse qi and relieves pain, enters the kidney to help vital fire, and dispels cold and relieves pain. Gan Jiang warms middle energizer to dispel cold, arrest vomiting, help Shu jiao to dispel cold, maltose warms middle energizer to supplement deficiency, relieve spasm and alleviate pain, ren Shen tonifies primordial qi and spleen-stomach qi, helps maltose rebuild middle-jiao to make middle-jiao full and middle-jiao full. The whole formula emphasizes on warming yang to stop vomiting. Can be used for treating postoperative spleen and stomach yang deficiency, yin cold and internal excess, abdominal pain, emesis, and anorexia.

Preferably, the raw material components of the traditional Chinese medicine composition also comprise: 2-3 parts of chlorella and 0.3-0.6 part of tea polyphenol.

Preferably, the ginseng is selected from ginseng total saponins, and the preparation method of the ginseng total saponins comprises the following steps: s201: slicing Ginseng radix, decocting in water, filtering, and collecting filtrate; wherein, the decoction is carried out twice by adding water, the first time is 2 hours, and the second time is 1.5 hours; s202: passing the filtrate through a resin adsorption column, eluting with water to colorless, eluting with 60% ethanol by mass, and collecting the ethanol eluate; wherein the resin adsorption column is D101 type macroporous adsorption column; s203: concentrating the ethanol eluent to obtain clear paste with the relative density of 1.06-1.08 at 80 ℃, and then drying and crushing to obtain the ginseng total saponin.

Preferably, the dried ginger is ginger fluid extract, and the preparation method of the ginger fluid extract comprises the following steps: s301: soaking the dried ginger powder in ethanol, percolating at the speed of 1-3 mL/min, and collecting primary percolate; s302: continuously percolating the product without the primary percolate until the percolate is colorless, and collecting the continuous percolate; then concentrating the subsequent percolate to a thick paste with the relative density of 1.2-1.3 at the temperature of 60 ℃; s303: mixing the primary percolate with the soft extract, and filtering to obtain rhizoma Zingiberis recens fluid extract.

The raw material medicines for preparing the traditional Chinese medicine composition are proportioned according to parts by mass, and can be increased or decreased according to corresponding proportions during production, for example, the mass production can be in kilogram or ton units, the small-scale production can also be in gram units, the weight can be increased or decreased, but the raw material medicine mass proportioning proportions among the components are unchanged.

In a second aspect, the present invention provides a method for preparing a Chinese medicinal composition, comprising the following steps: s101: uniformly mixing the raw material components, and then uniformly mixing the raw material components with the matrix paste to obtain a paste; wherein the mass ratio of the total mass of the raw material components to the matrix paste is 1: (4-10); s102: and uniformly coating the paste on the non-woven fabric of the back lining layer, and then pressing.

Preferably, the raw material components of the base paste comprise 1: l: 2 glycerin, gelatin and water; wherein, the gelatin, the glycerol and the water are heated and fused on a water bath according to a certain proportion, and then the water is distilled to obtain the matrix paste.

The traditional Chinese medicine composition prepared by the method can be further prepared into pharmaceutically acceptable dosage forms according to the needs. The pharmaceutical composition can be directly prepared or prepared after adding pharmaceutically acceptable auxiliary materials, and can be prepared into any pharmaceutically acceptable dosage form. The external preparation includes, for example: solution, patch, medicated wine, tincture, gel, liniment, aerosol, spray, ointment, suppository and plastics. The medicaments in various dosage forms can be prepared according to the conventional method in the pharmaceutical field.

In a third aspect, the invention provides an application of the traditional Chinese medicine composition in preparing a navel emplastrum product for promoting enterokinesia to exhaust and preventing intestinal adhesion.

Preferably, one patch is applied every 12h for a long-term bedridden patient; the plaster is applied to the patient after the general anesthesia surgery every 6 h; the local anesthesia patient is stuck every 6 hours after surgery, and 2-3 sticks are stuck every day; the patch is applied every 6h for abdominal distension and psychroalgia in the early menstrual period, and 2-3 patches are applied every day.

Preferably, after the traditional Chinese medicine composition is used, the enterokinesia and/or intestinal ventilation can be realized within 3-6 h after the surgical operation.

Specifically, the plaster prepared by the invention is applied on the navel of a patient after operation, the medicine is administered from the navel part (Shenque acupoint), the double-overlapping treatment effects of percutaneous absorption of the medicine and dredging of meridians and viscera by the acupoint are exerted, the medicine effect of the acupoint is integrated through meridians, so that the regulation function of the organism is stimulated, the inhibition of the area around the reflecting point is realized, and in addition, the medicine is detained at the acupoint to cause the focus of cerebral cortex to induce and keep the continuity of the medicine administration and the stability of the dosage, and the constant blood concentration is maintained.

Compared with the prior art, the technical scheme of the invention has the following advantages:

(1) the traditional Chinese medicine composition provided by the invention is prepared from pure traditional Chinese medicines, does not need injection, has no pain, is good in absorption, convenient to use, exact in curative effect, quick in effect taking, economical and practical. The traditional Chinese medicine composition is used for treating internal diseases by external application, has no side effect, can greatly meet and facilitate the urgent requirements of a clinician for recovering the intestinal function of a patient as soon as possible after operation, promoting intestinal peristalsis and intestinal ventilation and preventing intestinal adhesion, relieves the pain of patients who cannot take medicines and are difficult to take medicines, and overcomes the defects of the existing clinical treatment technology; and then make patient's food recovery physical power as early as possible, promote the healing of wound, reduce the number of days of being in hospital, alleviate family's economic burden, bring the facility to very big doctor and patient of facilitating.

(2) The navel administration is adopted, the navel administration is based on the unique shape that the navel is inwards sunken, the navel is suitable for medicine storage and fixation, the navel epidermis and the cuticle thereof are thinnest, the navel administration has the electrical characteristics of low impedance, large capacitance and high point position, specific acoustic and thermal changes are realized, the barrier function is weakest, no fat tissue exists below the navel, skin fascia is directly connected, the anatomical structure is easy for medicine permeation, the medicine transdermal absorption and the dredging of channels and collaterals and viscera are facilitated, the medicine entering a human body can directly act on the abdomen, the obvious channel leading-in property is realized, the intestinal peristalsis is promoted after the operation, the effect is rapid, and the curative effect is obvious. The temperature of the umbilical part is higher than that of other parts and is not easy to fluctuate because the umbilical part is adjacent to the small intestine inwards, so that the umbilical part skin has absolute absorption advantages compared with other parts. The umbilicus is sharp in sense, has good sensing function and conduction function, stimulates the skin of the umbilicus, adjusts the function of autonomic nerves of an organism through the reflection and conduction of a nervous system, improves the physiological activities of internal organs and tissues, and enhances the immunity of the organism, thereby achieving the purposes of building up the body, preventing and treating diseases. The drug molecules penetrated through the acupoint in umbilicus can be absorbed into blood through the capillary vessel of omentum majus, and enter the blood circulation through periumbilical vein net, accessory umbilical vein, portal vein, liver and inferior vena cava to reach target cells.

(3) The navel administration has the characteristics of thinnest epidermis cuticle, weakest barrier function, no subcutaneous fat tissue and direct connection of skin, fascia and peritoneum, and is favorable for the absorption of the medicament. The method avoids liver first pass effect and gastrointestinal inactivation which may occur in oral administration, protects liver, and reduces toxic damage; when the medicine is administrated in a percutaneous mode, the medicine maintains constant blood concentration, and the individual difference of patients is relatively reduced; can prolong the action time of the medicine and reduce the administration times and the total dose; can improve the therapeutic effect of the medicine.

(4) The navel administration is adopted, so that the defects of large administration dosage, more side effects, more decomposition products and serious aggravation of excretion system burden caused by that the active ingredients are often decomposed in a large amount when the traditional oral medicine is metabolized by the liver are avoided. The medicine absorbed by the navel middle acupuncture point has less amount of liver passing, less decomposition and less dosage, reaches the blood concentration required by treatment, has less toxic and side effects, avoids the stimulation of oral medicine to the gastrointestinal tract, is particularly suitable for the old, seriously ill patients and infants with difficult medicine taking, and is more easily accepted by patients.

(5) The traditional Chinese medicine composition has the characteristics that the traditional Chinese medicine oral administration and the western medicine oral administration and the injection do not have: the method is simple and easy to implement, free of adverse reaction and safe to use, overcomes the defects of the existing clinical treatment technology, and can quickly promote enterokinesia and intestinal ventilation after 3-6 hours of operation. Specifically, the traditional Chinese medicine composition can be used after the inhibition effect of the postoperative anesthetic is weakened, the gastrointestinal function of a patient can be awakened within 3-6 hours, the intestinal peristalsis is promoted, the intestinal adhesion is prevented, the exhaust time is shortened to be within 8 hours from 24-72 hours after operation, great convenience is brought to the patient, the pain of the patient who cannot take medicine and cannot take medicine easily is relieved, and the defects of the existing clinical treatment technology are overcome. In addition, the traditional Chinese medicine composition does not contain toxic or addictive components, is not easy to accumulate in vivo, does not generate drug resistance, and is worthy of clinical popularization and use by doctors and patients.

Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.

Detailed Description

Hereinafter, embodiments of the present invention will be described in detail. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.

The invention provides a traditional Chinese medicine composition for promoting intestinal peristalsis, which comprises the following raw material components in parts by weight: 6-10 parts of Sichuan pepper, 10-15 parts of dried ginger, 6-10 parts of ginseng and 20-30 parts of maltose.

Wherein, the ginseng is selected from ginseng total saponins, and the preparation method of the ginseng total saponins comprises the following steps: s201: slicing Ginseng radix, decocting in water, filtering, and collecting filtrate; wherein, the decoction is carried out twice by adding water, the first time is 2 hours, and the second time is 1.5 hours; s202: passing the filtrate through a resin adsorption column, eluting with water to colorless, eluting with 60% ethanol by mass, and collecting the ethanol eluate; wherein the resin adsorption column is D101 type macroporous adsorption column; s203: concentrating the ethanol eluent to obtain clear paste with the relative density of 1.06-1.08 at 80 ℃, and then drying and crushing to obtain the ginseng total saponin. The dried ginger is ginger fluid extract, and the preparation method of the ginger fluid extract comprises the following steps: s301: soaking the dried ginger powder in ethanol, percolating at the speed of 1-3 mL/min, and collecting primary percolate; s302: continuously percolating the product without the primary percolate until the percolate is colorless, and collecting the continuous percolate; then concentrating the subsequent percolate to a thick paste with the relative density of 1.2-1.3 at the temperature of 60 ℃; s303: mixing the primary percolate with the soft extract, and filtering to obtain rhizoma Zingiberis recens fluid extract.

Preferably, the raw material components further comprise: 2-3 parts of chlorella and 0.3-0.6 part of tea polyphenol.

In addition, aiming at the traditional Chinese medicine composition, the invention specially designs a preparation method, which comprises the following steps:

s101: uniformly mixing the raw material components, and then uniformly mixing the raw material components with the matrix paste to obtain a paste; wherein the mass ratio of the total mass of the raw material components to the matrix paste is 1: (4-10). Wherein, the raw material components of the matrix paste comprise 1: l: 2 glycerin, gelatin and water; wherein, the gelatin, the glycerol and the water are heated and fused on a water bath according to a certain proportion, and then the water is distilled to obtain the matrix paste.

S102: and uniformly coating the paste on the non-woven fabric of the back lining layer, and then pressing.

The following description is made with reference to specific embodiments:

example one

The invention provides a traditional Chinese medicine composition which comprises the following raw material components in parts by weight: 8 parts of Sichuan pepper, 10 parts of dried ginger, 9 parts of ginseng and 23 parts of maltose.

Wherein, removing impurities such as semen Zanthoxyli and carpopodium etc. with parching method (general rule 0213) to give fragrance, grinding, and sieving. Grinding maltose, and sieving. The ginseng is selected from ginseng total saponins, and the preparation method of the ginseng total saponins comprises the following steps: s201: slicing Ginseng radix, decocting in water, filtering, and collecting filtrate; wherein, the decoction is carried out twice by adding water, the first time is 2 hours, and the second time is 1.5 hours; s202: passing the filtrate through a resin adsorption column, eluting with water to colorless, eluting with 60% ethanol by mass, and collecting the ethanol eluate; wherein the resin adsorption column is D101 type macroporous adsorption column; s203: concentrating the ethanol eluent to obtain clear paste with the relative density of 1.06-1.08 at 80 ℃, and then drying and crushing to obtain the ginseng total saponin. The dried ginger is ginger fluid extract, and the preparation method of the ginger fluid extract comprises the following steps: s301: soaking the dried ginger powder in ethanol, percolating at the speed of 1-3 mL/min, and collecting primary percolate; s302: continuously percolating the product without the primary percolate until the percolate is colorless, and collecting the continuous percolate; then concentrating the subsequent percolate to a thick paste with the relative density of 1.2-1.3 at the temperature of 60 ℃; s303: mixing the primary percolate with the soft extract, and filtering to obtain rhizoma Zingiberis recens fluid extract.

The preparation of the traditional Chinese medicine composition required by the invention by adopting the raw material components comprises the following steps:

s101: uniformly mixing the raw material components, and then uniformly mixing the raw material components with the matrix paste to obtain a paste; wherein the mass ratio of the total mass of the raw material components to the matrix paste is 1: (4-10). Wherein, the raw material components of the matrix paste comprise 1: l: 2 glycerin, gelatin and water; heating gelatin, glycerol and water in a water bath according to a certain proportion for fusion, and then distilling to remove water to obtain a matrix paste.

Example two

The present embodiment is configured based on the first embodiment. In this example, the parameters are the same as in the first example except that the raw material components of the traditional Chinese medicine composition are different from those in the first example.

Specifically, the invention provides a traditional Chinese medicine composition which comprises the following raw material components in parts by weight: 10 parts of Sichuan pepper, 10 parts of dried ginger, 6 parts of ginseng and 30 parts of maltose.

EXAMPLE III

Specifically, the invention provides a traditional Chinese medicine composition which comprises the following raw material components in parts by weight: 8 parts of Sichuan pepper, 10 parts of dried ginger, 9 parts of ginseng, 23 parts of maltose, 2 parts of chlorella and 0.3 part of tea polyphenol.

In addition, to further illustrate the advantages of the technical solution of the present invention, the following functional experiments were performed:

first, observe the recovery case of intestinal tympanites

160 patients after abdominal surgery were collected; wherein, 30 cases after acute suppurative appendicitis complicated by peritonitis, 30 cases after pyloric obstruction, 20 cases after biliary tract infection, 20 cases after cholecystectomy, 30 cases after gastric perforation repair, and 30 cases after complete intestinal obstruction; among all patients, 100 cases of epidural anesthesia and 60 cases of general anesthesia were used.

Each patient was divided into 4 groups of 40 patients each. The first to third groups were observation groups using the drugs prepared in examples one to three, respectively; specifically, the observation group adopts a shenque acupoint external method of Chinese medicinal navel emplastrum; tearing the packaging bag open, taking out the patch, peeling off the anti-sticking layer, and sticking the plaster face on the navel (Shenque acupoint) which is cleaned and dried, wherein the plaster face is firmly stuck. The fourth group served as a control group, and the conventional method of intramuscular injection of neostigmine bromide was used. Both groups were observed 24h after treatment and were statistically processed.

The statistical method comprises the following steps: the two groups of treatment effects adopt' chi²Examination of

The curative effect is judged as follows: and (3) healing: obvious conscious intestinal peristalsis and anal exhaust reaction exist within 3-6 h, abdominal distension does not exist, 3-4 times per minute of intestinal sounding is auscultated, intestinal peristalsis occurs in abdominal palpation, and symptoms are obviously relieved. The effect is shown: the self-perceived enterokinesia and anus exhaust reaction are achieved within 6-12 h, no obvious abdominal distension is caused, the auscultation is performed for 2-3 times per minute, and the symptoms are relieved. The method has the following advantages: the voluntary enterokinesia and the exhaust reaction of the anus within 12-24 h have no obvious abdominal distension, and the symptoms are relieved. And (4) invalidation: within 24-72 h, no enterokinesia, no reduction of abdominal distension, no exhaust from anus and no improvement of symptoms are caused.

Table 1 comparison of the two treatment effects (example%)

The total effective rate of the observation group and the control group is shown in Chi²Inspection, P<0.05 suggests that the two groups have significant difference in curative effect.

Second, observe the recovery case of intestinal peristalsis

150 cases of treatment groups and control groups of hospitalized patients after surgery, tumor chemoradiotherapy and gynecology and obstetrics are collected; among them, 80 cases of tumor radiotherapy and chemotherapy, 44 cases after orthopedic surgery, 46 cases of acute appendicitis, 60 cases of biliary tract infection, 40 cases of caesarean section and 30 cases of spleen rupture. Each patient is divided into four groups, and the sex, age and disease type of the four groups of patients are compared, and the difference has no statistical significance (P >0.05) and is comparable.

The four groups of patients are treated conventionally after western medicine operation, namely anti-infection and symptomatic treatment, water and electrolyte balance maintenance, treatment support, early getting out of bed activity encouragement and the like. The first group to the third group are observation groups, the medicaments prepared in the first group to the third group are respectively used, the emplastrum of each embodiment is pasted on the navel acupoint immediately after operation, and each patch is used for 12 hours until the intestinal function is recovered; the fourth group served as control group and was treated by conventional western medicine treatment. Recording the recovery time of four groups of intestinal peristalsis and the anus exhaust time, and taking 4-5 times of bowel sounds/min as recovery indexes.

The standard of curative effect is determined according to 'surgical nursing' in combination with clinical symptoms and patient complaints. The effect is shown: the anus can automatically exhaust air within 24 hours after operation without abdominal distension. The method has the following advantages: the anus can automatically exhaust air within 24-48 h after operation, and no obvious abdominal distension exists. And (4) invalidation: no air was discharged from the anus for 48h after the operation, and abdominal distension was evident. Statistical processing was performed using SPSS17, 0 software, using the t-test, with P <0.05 indicating that the difference was statistically significant.

The treatment results are as follows: compared with the control group, the differences of the postoperative bowel sound recovery time and the first anus exhaust time of the patients in the treatment group have statistical significance (P is less than 0.05), and the postoperative bowel sound recovery time and the first anus exhaust time of the patients in the treatment group are obviously shortened.

TABLE 2 comparison of bowel sound recovery time and first anal ventilation time for two groups of patients: (

h)

Note: p <0.05 in comparison of the observed group with the control group

In addition, after the operation of each department, the recovery of intestinal peristalsis is related to the type of the operation and the anesthesia mode by using the intestinal ventilation navel emplastrum, the fastest time is about 3-6 h in the general orthopedic surgery, the second time is 4-8 h in the gynecological operation, and the slowest time is 6-12 h in the general surgery after long-term bedridden patients. Morphine used by tumor patients can act on spinal cord and midbrain opioid receptors, acts on small intestine through peripheral nerves, inhibits intestinal peristalsis, has good postoperative analgesia, can reduce complications caused by postoperative stress response, and is beneficial to the recovery of gastrointestinal function.

Of course, other kinds and ratios of the raw material components, conditions and parameters in the production process, and the like are also possible except the cases exemplified in examples one to three.

The traditional Chinese medicine composition provided by the invention is prepared from pure traditional Chinese medicines, does not need injection, has no pain, is good in absorption, convenient to use, exact in curative effect, quick in effect taking, economical and practical. The traditional Chinese medicine composition is used for treating internal diseases by external application, has no side effect, can greatly meet and facilitate the urgent requirements of a clinician for recovering the intestinal function of a patient as soon as possible after operation, promoting intestinal peristalsis and intestinal ventilation and preventing intestinal adhesion, relieves the pain of patients who cannot take medicines and are difficult to take medicines, and overcomes the defects of the existing clinical treatment technology; and then make patient's food recovery physical power as early as possible, promote the healing of wound, reduce the number of days of being in hospital, alleviate family's economic burden, bring the facility to very big doctor and patient of facilitating.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.

Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.

Claims

1. A traditional Chinese medicine navel emplastrum for promoting intestinal peristalsis is characterized by comprising the following raw materials in parts by weight: 8 parts of Sichuan pepper, 10 parts of dried ginger, 9 parts of ginseng, 23 parts of maltose, 2 parts of chlorella and 0.3 part of tea polyphenol, and the tea beverage is prepared by the following steps:

(1) removing impurities from semen Zanthoxyli and carpopodium, parching to give fragrance, grinding, and sieving; grinding maltose, and sieving;

(2) the ginseng is prepared into the ginseng total saponin by the following steps:

s201: slicing Ginseng radix, decocting in water, filtering, and collecting filtrate; wherein, the decoction is carried out twice by adding water, the first time is 2 hours, and the second time is 1.5 hours;

s202: passing the filtrate through a resin adsorption column, eluting with water to colorless, eluting with 60% ethanol by mass, and collecting the ethanol eluate; wherein the resin adsorption column is D101 type macroporous adsorption column;

s203: concentrating the ethanol eluent to obtain clear paste with the relative density of 1.06-1.08 at 80 ℃, and then drying and crushing to obtain the ginseng total saponin;

(3) preparing ginger fluid extract from the dried ginger by the following steps:

s301: soaking the dried ginger powder in ethanol, percolating at the speed of 1-3 mL/min, and collecting primary percolate;

s302: continuously percolating the product without the primary percolate until the percolate is colorless, and collecting the continuous percolate; then concentrating the subsequent percolate to a thick paste with the relative density of 1.2-1.3 at the temperature of 60 ℃;

s303: mixing the primary percolate with the soft extract, and filtering to obtain rhizoma Zingiberis recens fluid extract;

(4) the Chinese medicinal navel emplastrum is prepared by the following steps:

s101: uniformly mixing the raw material components, and then uniformly mixing the raw material components with the matrix paste to obtain a paste; wherein the mass ratio of the total mass of the raw material components to the matrix paste is 1: (4-10), wherein the matrix paste comprises the following components in a mass ratio of 1: 1: 2, heating and fusing the gelatin, the glycerol and the water on a water bath according to a proportion, and then distilling to remove water to obtain a matrix paste;

2. The use of the Chinese medicinal navel patch according to claim 1 in the preparation of a medicament for promoting enterokinesia to expel air and preventing intestinal adhesion.