CN112641845A - Traditional Chinese medicine composition for relieving distension and relaxing bowels and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for relieving distension and relaxing bowels and preparation method and application thereof Download PDFInfo
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- CN112641845A CN112641845A CN202110065757.9A CN202110065757A CN112641845A CN 112641845 A CN112641845 A CN 112641845A CN 202110065757 A CN202110065757 A CN 202110065757A CN 112641845 A CN112641845 A CN 112641845A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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Abstract
The invention relates to a traditional Chinese medicine composition for relieving distension and relaxing bowels, which comprises the following components in parts by weight: 3-100 parts of rheum officinale, 10-200 parts of immature bitter orange, 12-200 parts of mirabilite, 5-50 parts of clove, 8-150 parts of elecampane, 14-200 parts of cortex magnoliae officinalis and 13-200 parts of radish seed. The medicinal patch prepared from the traditional Chinese medicine composition can relieve constipation symptoms, and has the advantages of good stability, convenience in operation and no toxic or side effect.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition for relieving distension and relaxing bowels, and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines.
Background
Constipation is one of the common manifestations of gastrointestinal dysfunction worldwide, and with the change of life style and the coming of aging population, the prevalence rate of constipation gradually increases, and the influence of constipation on life and work of people and the medical burden caused by the constipation also increase day by day.
Constipation is generally manifested by a reduced number of bowel movements, hard and dry stools and/or difficulty in defecation. A decrease in bowel movements means <3 bowel movements per week. The difficult defecation comprises the labor waste, difficult defecation, endless defecation, time waste and the need of manipulation for assisting defecation. Chronic constipation means that the course of constipation is at least 6 months. Since the causes of constipation are numerous, including functional diseases and organic diseases, functional diseases can be considered after first eliminating constipation caused by organic diseases and pharmaceutical factors. The treatment of constipation adopts individual comprehensive treatment measures in principle, including recommending reasonable dietary structure, establishing correct defecation habits, and adjusting the psychology of patients; the etiology treatment is carried out on the patient with definite etiology; the cathartic is used reasonably, and if necessary, the operation is adopted for treatment.
For constipation caused by non-organic diseases, modern clinical treatment usually adopts medicinal or non-medicinal treatment means besides health promotion and education and help patients to establish healthy life style. The treatment of the medicine comprises oral cathartic or anal administration, but the oral cathartic has more side effects, and the long-term administration can damage the peripheral nerve of the intestinal tract, interfere the normal movement rule of the intestinal tract, destroy the autonomous defecation function of the human body and slowly form medicine dependence. The intra-anal administration requires certain operation technology and equipment, and is not suitable for daily household treatment. In non-drug treatment, biofeedback can train the functions of pelvic floor muscles of patients and improve constipation symptoms, but the actual operation is complex, and the method is not widely popularized at present. The operation treatment brings more pain and risk to the patient, the postoperative care consumes a great deal of time and energy, and the patient acceptance is low. Therefore, a convenient, effective and safe treatment measure is found, so that the constipation treating medicine is generally and easily accepted by patients, is economic, convenient and suitable for popularization, and becomes a key factor for solving the problem of constipation treatment at present.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides the traditional Chinese medicine composition for relieving distension and relaxing bowels, and the preparation method and the application thereof.
In order to achieve the purpose, the invention adopts the technical scheme that: a traditional Chinese medicine composition for relieving distension and relaxing bowels comprises the following components in parts by weight: 3-100 parts of rheum officinale, 10-200 parts of immature bitter orange, 12-200 parts of mirabilite, 5-50 parts of clove, 8-150 parts of elecampane, 14-200 parts of cortex magnoliae officinalis and 13-200 parts of radish seed.
The rhubarb in the formula can clear intestinal tracts, purge heat and relax bowels, and the active ingredient of the rhubarb is sennoside which can increase intestinal peristalsis and inhibit the water absorption in intestines to promote defecation. Fructus Aurantii is pungent, bitter and slightly warm in nature. Enter spleen and stomach meridians. Has the effects of promoting qi circulation, relieving epigastric distention, removing phlegm and relieving stuffiness. Natrii sulfas is bitter and salty, and has effects of clearing heat, purging and softening hard masses. Modern pharmacological studies show that sodium sulfate contained in the composition is not easily absorbed by the intestinal wall, and can cause a high-permeability state in the intestine, so that the absorption of water in the intestine is prevented, the volume of intestinal contents is increased, mechanical stimulation is caused, and the intestinal peristalsis is promoted to defecate. Flos Caryophylli is pungent in flavor and warm in nature, and has effects of warming middle-jiao, lowering adverse qi, invigorating kidney and tonifying yang. The clove oil as the effective component can effectively relieve abdominal flatulence, enhance digestion function and relieve nausea and vomiting. Mu Xiang warms the middle-jiao, promotes qi circulation, relieves pain, strengthens the spleen, promotes digestion and removes food stagnation. The costustoot water extract, the volatile oil and the total alkaloids can obviously enhance the intestinal peristalsis amplitude and the intestinal muscle tension of the isolated rabbit. Magnolia officinalis is warm in nature, pungent and bitter in taste, and has the effects of eliminating dampness and phlegm, and descending qi and relieving fullness. Small doses stimulate the smooth muscle of the gut tube, while large doses have an inhibitory effect. Parched Raphani semen has effects of resolving food stagnation, relieving flatulence, and enhancing intestinal rhythmic contraction to achieve defecation effect.
As a preferred embodiment of the traditional Chinese medicine composition, the traditional Chinese medicine composition comprises the following components in parts by weight: 94 parts of rhubarb, 188 parts of immature bitter orange, 188 parts of mirabilite, 31 parts of clove, 125 parts of costus root, 188 parts of magnolia officinalis containing ginger and 188 parts of radish seed.
In a second aspect, the invention provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: mixing the raw materials at a certain proportion, pulverizing into fine powder, mixing, and sieving to obtain the Chinese medicinal composition.
As a preferred embodiment of the preparation method of the present invention, the mesh number of the sieve is 100 meshes.
In a third aspect, the invention provides a pharmaceutical preparation, which comprises the above traditional Chinese medicine composition.
As a preferred embodiment of the pharmaceutical preparation according to the present invention, the pharmaceutical preparation further comprises pharmaceutically acceptable excipients.
As a preferable embodiment of the pharmaceutical preparation, the pharmaceutical preparation is in the form of tablets, granules, capsules, mixtures, pills, dripping pills, solid dispersants or patches.
In a fourth aspect, the invention provides a medicinal patch for relieving distension and relaxing bowels, which comprises the traditional Chinese medicine composition.
The navel application therapy is a traditional Chinese therapy with a long history, is recorded in the earliest medical book 'fifty two diseases prescription' of China, and is discussed by doctors of all generations afterwards. The umbilicus is an important acupoint in the meridian system, belongs to the conception vessel, which is the sea of yin vessels, and connects the governor vessel and the thoroughfare vessel, which are the sources of three branches, with the channels of the whole body, so the traditional Chinese medicine has the theory of 'navel dredging all channels'. Modern medical research shows that the epidermis cuticle of the umbilical skin is thin, the barrier function is poor, fat tissues are not arranged under the umbilicus, and the skin fascia is directly connected with the peritoneum, so that the permeability is strong, and drug molecules easily penetrate through the cuticle of the umbilical skin, enter intercellular substance and rapidly diffuse into blood to reach the whole body. Besides local skin circulation, there are inferior abdominal wall arteries on both sides of the umbilicus, and there are abundant capillary networks, and the umbilicus can retain the drug for a long time, so the application of the drug can make the drug quickly permeate and absorb to exert the drug effect.
The traditional Chinese medicine composition is prepared into the plaster, belongs to an external medicine, is convenient to store and operate, has small absolute dosage of the medicine applied each time, basically has no toxic or side effect, and is convenient to use in various health care institutions and home health care application.
As a preferred embodiment of the patch of the present invention, the patch further comprises a pharmaceutically acceptable adjuvant.
In a fifth aspect, the present invention provides a method for preparing the above patch, comprising the steps of: adding pharmaceutically acceptable adjuvants into the Chinese medicinal composition, concocting into paste, making into unguent as medicine core, and fixing the medicine core with medical adhesive plaster to obtain the patch.
Preferably, the pharmaceutically acceptable auxiliary materials are sesame oil and honey.
More preferably, the form of the Chinese medicinal composition is convenient for storage, and a little sesame oil and honey are mixed into paste for each use, so that the Chinese medicinal composition can be prepared into a fixed dosage form for acupoint application and is convenient for application.
Compared with the prior art, the invention has the beneficial effects that: the medicinal patch prepared from the traditional Chinese medicine composition can relieve constipation symptoms, and has the advantages of good stability, convenience in operation and no toxic or side effect.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
A traditional Chinese medicine composition for relieving distension and relaxing bowels comprises the following components in parts by weight: 94g of rhubarb, 188g of immature bitter orange, 188g of mirabilite, 31g of clove, 125g of costus root, 188g of ginger officinal magnolia bark and 188g of radish seed.
A medicinal patch for relieving flatulence and relaxing bowels comprises the traditional Chinese medicine composition.
The preparation method of the patch of the embodiment comprises the following steps: mixing the raw materials at a certain proportion, pulverizing into fine powder, mixing, sieving with 100 mesh sieve to obtain Chinese medicinal composition, mixing with small amount of oleum Sesami and Mel to obtain paste, making into unguent as medicine core, fixing the medicine core with medical adhesive plaster, and making into medicinal patch.
The patch of this example was used clinically, and the swelling and bowel relaxing powder was used for the last 5 years as shown in table 1.
TABLE 1
| Year of year | 2015 years | 2016 (year) | 2017 | 2018 years old | 2019 |
| Number of times of use | 395 | 402 | 561 | 611 | 644 |
Example 2
A traditional Chinese medicine composition for relieving distension and relaxing bowels comprises the following components in parts by weight: 3g of rhubarb, 10g of immature bitter orange, 12g of mirabilite, 5g of clove, 8g of costus root, 14g of magnolia officinalis with ginger and 13g of radish seed.
A medicinal patch for relieving flatulence and relaxing bowels comprises the traditional Chinese medicine composition.
The method of preparation of the patch of this example was the same as that of example 1.
Example 3
A traditional Chinese medicine composition for relieving distension and relaxing bowels comprises the following components in parts by weight: 100g of rhubarb, 200g of immature bitter orange, 200g of mirabilite, 50g of clove, 150g of costustoot, 200g of cortex magnoliae officinalis and 200g of radish seed.
A medicinal patch for relieving flatulence and relaxing bowels comprises the traditional Chinese medicine composition.
The method of preparation of the patch of this example was the same as that of example 1.
Effect example 1
The difficulty of repeated defecation in certain age is more than 10 years, 1 week admission is increased, and the traditional Chinese medicine diagnosis of admission: constipation (qi deficiency), western medicine diagnosis: 1. functional constipation; 2. benign tumors of the duodenum (adenomatous ESD postoperative); 3. thyroid nodule (left). After admission, the patient treated the acupoint application example 1, with symptoms changed, stools 1 time a day, and soft and formed.
Effect example 2
Old people have difficulty in defecation repeatedly for more than 2 months and abdominal distension for 1 month. Admission traditional Chinese medicine diagnosis: constipation (qi deficiency). And (3) Western diagnosis: constipation (cause: colon tumor or functional constipation); hypertension (high risk group); hyperuricemia; an I-degree atrioventricular block; lower limb arteriosclerosis and plaque formation; osteoporosis; fracture of thoracic vertebrae; femoral intertrochanteric fractures. In the treatment, the medicament inhibits the synthesis of uric acid, regulates fat, stabilizes speckles, prevents infection and the like, and is matched with the acupoint application treatment of the example 2, so that the symptoms of a patient are improved through treatment.
Effect example 3
Repeated constipation with mucus and bloody stool is conducted slowly for more than 20 years, and colorectal polyps are found for 10 days. Admission traditional Chinese medicine diagnosis: constipation (heat constipation) western medicine diagnosis: ulcerative colitis (rectal mild); rectal polyps. In example 3, the patient's symptoms improved by the acupoint application therapy.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for relieving distension and relaxing bowels is characterized by comprising the following components in parts by weight: 3-100 parts of rheum officinale, 10-200 parts of immature bitter orange, 12-200 parts of mirabilite, 5-50 parts of clove, 8-150 parts of elecampane, 14-200 parts of cortex magnoliae officinalis and 13-200 parts of radish seed.
2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 94 parts of rhubarb, 188 parts of immature bitter orange, 188 parts of mirabilite, 31 parts of clove, 125 parts of costus root, 188 parts of magnolia officinalis containing ginger and 188 parts of radish seed.
3. The method for preparing a Chinese medicinal composition according to claim 1 or 2, comprising the steps of: mixing the raw materials at a certain proportion, pulverizing into fine powder, mixing, and sieving to obtain the Chinese medicinal composition.
4. The method of claim 3, wherein the screened mesh size is 100 mesh.
5. A pharmaceutical preparation, which comprises the Chinese medicinal composition according to any one of claims 1 to 2.
6. The pharmaceutical formulation of claim 5, further comprising a pharmaceutically acceptable excipient.
7. The pharmaceutical preparation of claim 5, wherein the pharmaceutical preparation is in the form of tablets, granules, capsules, mixtures, pills, drops, solid dispersions or patches.
8. A patch for relieving distension and constipation, which comprises the Chinese medicinal composition as claimed in any one of claims 1 to 2.
9. The patch of claim 8, further comprising a pharmaceutically acceptable excipient.
10. A method of manufacturing a patch according to claim 8 or 9, comprising the steps of: adding pharmaceutically acceptable adjuvants into the Chinese medicinal composition, concocting into paste, making into unguent as medicine core, and fixing the medicine core with medical adhesive plaster to obtain the patch.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110065757.9A CN112641845A (en) | 2021-01-18 | 2021-01-18 | Traditional Chinese medicine composition for relieving distension and relaxing bowels and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110065757.9A CN112641845A (en) | 2021-01-18 | 2021-01-18 | Traditional Chinese medicine composition for relieving distension and relaxing bowels and preparation method and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435264A (en) * | 2014-11-14 | 2015-03-25 | 陈绍娟 | Medicine for treating intestine obstruction |
| CN104758422A (en) * | 2015-04-01 | 2015-07-08 | 沈阳赛镝医疗器械有限公司 | Traditional Chinese medicinal ultrasonic coupled patch |
| CN108030818A (en) * | 2017-12-26 | 2018-05-15 | 许书银 | Chinese medicine composition for treating constipation and preparation method thereof |
| CN110448629A (en) * | 2019-08-28 | 2019-11-15 | 余姚市中医医院 | A kind of Chinese medicine composition for treating constipation |
-
2021
- 2021-01-18 CN CN202110065757.9A patent/CN112641845A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435264A (en) * | 2014-11-14 | 2015-03-25 | 陈绍娟 | Medicine for treating intestine obstruction |
| CN104758422A (en) * | 2015-04-01 | 2015-07-08 | 沈阳赛镝医疗器械有限公司 | Traditional Chinese medicinal ultrasonic coupled patch |
| CN108030818A (en) * | 2017-12-26 | 2018-05-15 | 许书银 | Chinese medicine composition for treating constipation and preparation method thereof |
| CN110448629A (en) * | 2019-08-28 | 2019-11-15 | 余姚市中医医院 | A kind of Chinese medicine composition for treating constipation |
Non-Patent Citations (4)
| Title |
|---|
| 孙鹏云，等: "灸法为主治疗功能性便秘临床研究简况", 《中医药临床杂志》 * |
| 王德申: "药物敷脐疗法在中医急症方面的应用", 《医学信息》 * |
| 罗琼，等: "中药外敷神阙穴加灸法治疗老年功能性便秘50例疗效观察", 《中国社区医师》 * |
| 苏玉新: "经方验案三则", 《时珍国医国药》 * |
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