CN113209205A - Traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction and a preparation method thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 40-60 parts of areca peel, 40-60 parts of immature bitter orange, 40-60 parts of fried radish seed, 40-60 parts of mirabilite, 30-50 parts of scorched areca nut, 30-50 parts of magnolia officinalis and 10-30 parts of raw rhubarb. The traditional Chinese medicine composition is prepared into paste and is pasted on the umbilical region of a patient, has a good treatment effect on gastrointestinal dysfunction caused by gastrointestinal accumulated heat, can improve the clinical symptoms of abdominal distension and pain, mental fatigue and fatigue, constipation and the like of the patient, enhances gastrointestinal motility, and improves the gastrointestinal barrier function and the ischemia and anoxia state.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine formulas, in particular to a traditional Chinese medicine composition for treating critical gastrointestinal dysfunction and a preparation method thereof.
Background
For gastrointestinal dysfunction, western medicine treatment usually includes drugs for enhancing gastrointestinal motility, gastrointestinal decompression through indwelling gastric tubes, mucosal protective agents and the like, and usually has difficult effect or little curative effect, while traditional Chinese medicine divides gastrointestinal dysfunction into deficiency syndrome and excess syndrome, traditional Chinese medicine treatment for excess syndrome all tends to decoction for purging fu organs, such as qi-supporting decoction, but critical patients generally have serious illness, oral traditional Chinese medicine decoction has poor compliance, and the purgative agent is easy to correct the excessive, and meanwhile, when gastrointestinal dysfunction exists, the decoction is difficult to absorb and utilize.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction and a preparation method thereof in order to solve the technical problems.
The invention is realized by the following technical scheme.
A traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction comprises the following components in parts by weight:
40-60 parts of areca peel, 40-60 parts of immature bitter orange, 40-60 parts of fried radish seed, 40-60 parts of mirabilite, 30-50 parts of scorched areca nut, 30-50 parts of magnolia officinalis and 10-30 parts of raw rhubarb.
Further, the traditional Chinese medicine composition for treating the critically ill gastrointestinal dysfunction comprises the following components in parts by weight:
50 parts of areca peel, 50 parts of immature bitter orange, 50 parts of fried radish seed, 50 parts of mirabilite, 40 parts of burnt areca nut, 40 parts of mangnolia officinalis and 20 parts of raw rhubarb.
The traditional Chinese medicine composition is a proved formula which is clinically summarized for a long time, and comprises pericarpium arecae, immature bitter orange, fried radish seed, mirabilite, scorched areca nut, magnolia officinalis and raw rhubarb. The monarch drug rhubarb in the prescription is bitter and cold in nature and can purge heat toxin, break food retention and remove blood stasis, the traditional Chinese medicine means that the rhubarb can wash out the stomach and intestine, push away old to cause novelty, regulate middle energizer to eliminate food, calm the five internal organs, the anthraquinone derivative in the rhubarb has the strongest purging effect, can block the generation of prostaglandin E in the body temperature center to a certain extent and expand peripheral blood vessels to play a role in relieving fever; the ministerial drug mirabilite helps monarch rhubarb to purge heat and relax bowels, and can soften hardness and moisten dryness, the mirabilite has important effects on local microcirculation and stimulation of gastrointestinal peristalsis, can promote the discharge of peritoneal exudate through gastrointestinal tracts, effectively improves the gastrointestinal digestion function, promotes the recovery of the gastrointestinal function, and can stimulate the proliferation of a reticuloendothelial system to enhance the anti-inflammatory effect, and the rhubarb and the mirabilite are mutually reinforced to be used and strongly discharge heat; accumulation in the interior can obstruct qi of the fu-organs, and cortex Magnolia officinalis and fructus Aurantii Immaturus can be added to promote qi circulation and dissipate stagnation, relieve stuffiness and relieve fullness, and magnolol can be extracted from cortex Magnolia officinalis and has pharmacological effects of inhibiting inflammation, resisting bacteria and regulating gastrointestinal motility. The research result shows that magnolol can improve gastrointestinal dyskinesia caused by critical illness. In the mechanism exploration about immature bitter orange, immature bitter orange is discovered, and the gastrointestinal movement and evacuation are promoted by increasing the tension of the smooth muscle of the fundus and small intestine, so that the expelling rate of the contents is increased. Areca peel, areca nut peel, is pungent in taste, slightly warm in nature, enters spleen, stomach, large intestine and small intestine meridians, promotes qi circulation, relieves epigastric distention, promotes diuresis and reduces edema, mainly contains arecoline, accessory arecoline and the like, can excite gastrointestinal smooth muscle, and has the effects of promoting gastrointestinal motility, inhibiting intestinal endotoxin displacement and the like. Stir-baked radish seed is mild in nature, pungent and sweet in flavor, enters lung, spleen and stomach meridians, and has the actions of promoting digestion, relieving flatulence, descending qi and resolving phlegm. Danxi cloud: the radish seed phlegm-treatment effect is achieved by flushing the wall and pouring the wall, contains chemical components such as alkaloid, thioglucoside, flavone, protein, polysaccharide and the like, has the effect of promoting gastrointestinal motility, and is found to enhance the bladder contraction force and promote the recovery of spontaneous urination by applying the radish seed to the Shenque point to treat urinary retention. The traditional Chinese medicine composition has the effects of regulating gastrointestinal motility, digestive juice and gastrointestinal hormone secretion, protecting gastrointestinal mucosa, improving the immune function of the intestinal mucosa, regulating the microecological balance of intestinal tracts, enhancing the immune function of organisms, resisting bacteria and diminishing inflammation and the like, and can further prevent and improve the occurrence and development of critical gastrointestinal dysfunction.
A preparation method of a traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction comprises the following steps:
s1, weighing specified amounts of pericarpium arecae, immature bitter orange, fried radish seed, mirabilite, scorched areca nut, magnolia officinalis and raw rhubarb, and adding water to immerse the medicine powder by 1-3 cm;
s2, decocting the medicinal materials, boiling for 20-30min, and collecting a first decoction;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
and S4, combining the first decoction and the second decoction, heating and concentrating the mixture into paste to obtain the Chinese medicinal composition.
The present application has the following advantageous effects.
The traditional Chinese medicine composition has a good treatment effect on gastrointestinal dysfunction caused by heat accumulation in intestines and stomach, can improve clinical symptoms of abdominal distension and pain, mental fatigue and fatigue, constipation and the like of patients, enhances gastrointestinal motility, and improves gastrointestinal barrier function and ischemia and hypoxia state. The traditional Chinese medicine composition is reasonable and scientific in compatibility, has an excellent treatment effect, meets the requirements of clinical treatment, and improves the life quality of patients.
Detailed Description
Example 1
A preparation method of a traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction comprises the following steps:
s1, weighing 40g of areca peel, 60g of immature bitter orange, 40g of fried radish seed, 60g of mirabilite, 30g of scorched areca nut, 50g of magnolia officinalis and 10g of raw rhubarb, and adding water to immerse the medicine surface by 1 cm;
s2, decocting the medicinal materials, boiling for 20min, and collecting a first decoction;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
s4, combining the first decoction and the second decoction, heating and concentrating into paste;
s5, the pasty traditional Chinese medicine obtained in the step S4 is smeared on a base material and is pasted on the umbilical region of a patient.
Example 2
A preparation method of a traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction comprises the following steps:
s1, weighing 60g of areca peel, 40g of immature bitter orange, 60g of fried radish seed, 40g of mirabilite, 50g of scorched areca nut, 30g of magnolia officinalis and 30g of raw rhubarb, and adding water to submerge the medicine surface by 3 cm;
s2, decocting the medicinal materials, boiling for 30min, and collecting a first decoction;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
s4, combining the first decoction and the second decoction, heating and concentrating into paste;
s5, the pasty traditional Chinese medicine obtained in the step S4 is smeared on a base material and is pasted on the umbilical region of a patient.
Example 3
A preparation method of a traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction comprises the following steps:
s1, weighing 50g of areca peel, 50g of immature bitter orange, 50g of fried radish seed, 50g of mirabilite, 40g of scorched areca nut, 40g of magnolia officinalis and 20g of raw rhubarb, and adding water to immerse the medicine surface by 2 cm;
s2, decocting the medicinal materials, boiling for 30min, and collecting a first decoction;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
s4, combining the first decoction and the second decoction, heating and concentrating into paste;
s5, the pasty traditional Chinese medicine obtained in the step S4 is smeared on a base material and is pasted on the umbilical region of a patient.
When 512 subjects are treated by the traditional Chinese medicine preparation prepared in the application example 3, 66 cases are cured, 234 cases with obvious effect, 176 cases with effect and 36 cases with no effect, and the effective rate is about 92.97%.
Clinical trial
The patients come from 412 cases of critically ill gastrointestinal dysfunction diagnosed by an emergency intensive care unit of a hospital in 7 months to 2021 months in 2017. According to the principle of random and comparison, passing through SPSS 21.0 generates random numbers and groupsTwo groups are 206 cases. The serial number, random number, grouping and treatment scheme are written on paper and sealed in numbered envelopes, when patients enter the study, the envelopes are opened in sequence, and treatment is carried out according to the corresponding scheme strictly.
The treatment groups (the traditional Chinese medicine preparation prepared in the embodiment 3 of the application) comprise 112 male patients and 94 female patients; the age is 41-89 years, and the average (69.98 +/-12.08) years; sources of infectious foci: 79 cases of lower respiratory tract, 34 cases of pancreas and liver and gall, 56 cases of urinary tract and 37 cases of gastrointestinal tract; basic diseases: 127 cases of hypertension, 92 cases of coronary heart disease, 78 cases of type 2 diabetes and complications thereof, 62 cases of cerebral infarction sequelae and 69 cases of heart failure. Control group (without any drug) 107 men and 99 women; the age is 47-90 years, and the average (71.05 +/-11.05) years; sources of infectious foci: 84 cases of lower respiratory tract, 47 cases of pancreas and liver and gall, 52 cases of urinary tract and 23 cases of gastrointestinal tract; basic diseases: 119 cases of hypertension, 104 cases of coronary heart disease, 85 cases of type 2 diabetes and complications thereof, 58 cases of cerebral infarction sequelae and 75 cases of heart failure. Comparison of the two groups of pre-intervention basic conditions, the differences being statistically insignificant (P> 0.05) are comparable.
As a result: the difference is statistically significant after treatment and before treatment for the control group with higher SOFA score than before treatment (P< 0.05); the SOFA score and the intra-abdominal pressure after treatment in the treatment group are lower than those in the pre-treatment group and the control group, the abdominal circumference is shorter than those in the pre-treatment group and the control group, and the difference has statistical significance (P< 0.05). The score of gastrointestinal dysfunction and the traditional Chinese medicine syndrome score after the treatment of the control group are lower than those before the treatment, and the difference has statistical significance (P< 0.05); the frequency of bowel sounds after treatment in the treatment group is more than that before treatment and that in the control group, the scores of gastrointestinal dysfunction and the traditional Chinese medicine syndrome score are lower than those before treatment and that in the control group, and the difference has statistical significance (P< 0.05). Serum intestinal fatty acid binding protein (IFAB) after control group treatmentP) The level was lower than before treatment, the difference was statistically significant: (P< 0.05); post treatment IFAB of treatment groupsPAnd D-lactic acid levels were lower than those of the pretreatment and control groups, and the differences were statistically significant (P< 0.05). The total effective rate of the traditional Chinese medicine syndrome curative effect and the comprehensive curative effect of the treatment group are higher than those of the control group, and the difference is statisticalMeans (P< 0.05). The incidence of the multi-organ dysfunction syndrome in the treatment group is lower than that in the control group, and the difference has statistical significance (P＜0.05）。
And (4) conclusion: the traditional Chinese medicine composition can improve the clinical symptoms of abdominal distension and pain, mental fatigue and fatigue, constipation and the like of patients, enhance gastrointestinal motility, and improve gastrointestinal barrier function and ischemia and anoxia state.
The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.
Claims (3)
1. A traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction is characterized in that: the paint comprises the following components in parts by weight:
40-60 parts of areca peel, 40-60 parts of immature bitter orange, 40-60 parts of fried radish seed, 40-60 parts of mirabilite, 30-50 parts of scorched areca nut, 30-50 parts of magnolia officinalis and 10-30 parts of raw rhubarb.
2. The traditional Chinese medicine composition for treating critically ill gastrointestinal dysfunction according to claim 1, which is characterized in that: the paint comprises the following components in parts by weight:
50 parts of areca peel, 50 parts of immature bitter orange, 50 parts of fried radish seed, 50 parts of mirabilite, 40 parts of burnt areca nut, 40 parts of mangnolia officinalis and 20 parts of raw rhubarb.
3. A method for preparing the Chinese medicinal composition for treating critically ill gastrointestinal dysfunction according to claim 1 or 2, which is characterized by comprising the following steps: the method comprises the following steps:
s1, weighing specified amounts of pericarpium arecae, immature bitter orange, fried radish seed, mirabilite, scorched areca nut, magnolia officinalis and raw rhubarb, and adding water to immerse the medicine powder by 1-3 cm;
s2, decocting the medicinal materials, boiling for 20-30min, and collecting a first decoction;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
and S4, combining the first decoction and the second decoction, heating and concentrating the mixture into paste to obtain the Chinese medicinal composition.
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Application publication date: 20210806 |