CN104754954B - 转基因微藻和其用于口服递送蛋白质的用途 - Google Patents

转基因微藻和其用于口服递送蛋白质的用途 Download PDF

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CN104754954B
CN104754954B CN201380055161.4A CN201380055161A CN104754954B CN 104754954 B CN104754954 B CN 104754954B CN 201380055161 A CN201380055161 A CN 201380055161A CN 104754954 B CN104754954 B CN 104754954B
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protein
algae
microalgae
fish
hormone
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CN104754954A (zh
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西瑞·摩什茨科
多伦·艾森施塔特
盖伊·列维
奥芙拉·陈
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TransAlgae Ltd
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TransAlgae Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/05—Fusion polypeptide containing a localisation/targetting motif containing a GOLGI retention signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Wood Science & Technology (AREA)
  • Botany (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Insects & Arthropods (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
CN201380055161.4A 2012-08-23 2013-08-21 转基因微藻和其用于口服递送蛋白质的用途 Active CN104754954B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810827536.9A CN108929855A (zh) 2012-08-23 2013-08-21 转基因微藻和其用于口服递送蛋白质的用途

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261692240P 2012-08-23 2012-08-23
US61/692,240 2012-08-23
US201361781103P 2013-03-14 2013-03-14
US61/781,103 2013-03-14
PCT/IL2013/050712 WO2014030165A1 (en) 2012-08-23 2013-08-21 Transgenic microalgae and use thereof for oral delivery of proteins

Related Child Applications (1)

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CN104754954A CN104754954A (zh) 2015-07-01
CN104754954B true CN104754954B (zh) 2018-08-28

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CN201380055161.4A Active CN104754954B (zh) 2012-08-23 2013-08-21 转基因微藻和其用于口服递送蛋白质的用途

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US (2) US9827280B2 (enExample)
EP (1) EP2887819B1 (enExample)
JP (1) JP6275143B2 (enExample)
CN (2) CN108929855A (enExample)
CA (1) CA2882977C (enExample)
IL (1) IL237359B (enExample)
IN (1) IN2015MN00403A (enExample)
TR (1) TR201814868T4 (enExample)
WO (1) WO2014030165A1 (enExample)

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CA2935635C (en) * 2014-02-12 2023-05-09 Transalgae Israel Ltd. Algal based edible vaccines
US20190373915A1 (en) * 2014-10-24 2019-12-12 Trustees Of Dartmouth College Aquaculture Feed Formulation and Aquaculture Product Produced with the Same
CL2014003348A1 (es) * 2014-12-09 2016-09-02 Oceaneos Environmental Solutions Inc Isotopos de hierro no radiactivos y método de uso para rastrear especies marinas
JP2017012135A (ja) * 2015-07-06 2017-01-19 国立大学法人高知大学 ベクター、遺伝子組み換え海産珪藻及びフコキサンチンの生成方法
CN107849515A (zh) * 2015-07-14 2018-03-27 特郎萨格以色列有限公司 转基因微藻及其作为用于递送干扰rna分子的饲料的用途
GB201616087D0 (en) * 2016-09-21 2016-11-02 Tomalgae Cvba Algae comprising therapeutic and/or nutritional agents
KR102013788B1 (ko) * 2016-11-04 2019-08-23 한국과학기술연구원 인간상피세포 성장인자 또는 피부침투성 인간상피세포 성장인자 발현용 벡터 및 상기 벡터로 형질전환된 미세조류
DK3459357T3 (da) * 2017-01-20 2025-02-10 Sanriku Fish Meal Co Ltd Fremgangsmåde til fremstilling af foder indeholdende væksthormon fra laks, foder indeholdende væksthormon fra laks og væske indeholdende væksthormon fra laks
KR102080864B1 (ko) * 2017-10-24 2020-02-24 주식회사 비엠바이오 항비만, 항당뇨 기능성을 갖는 미세조류를 이용한 기능성 애완동물 사료 조성물
NO20210919A1 (en) * 2018-12-21 2021-07-20 Xpertsea Solutions Inc Systems and methods for predicting growth of a population of organisms
JP2020202786A (ja) * 2019-06-17 2020-12-24 国立研究開発法人国際農林水産業研究センター 微細藻類の培養方法
CN111394381A (zh) * 2020-03-26 2020-07-10 上海海洋大学 mOrange和vp28穿梭载体富集至卤虫无节幼体的方法
AU2023288053A1 (en) * 2022-06-22 2024-12-12 Provectus Algae Pty Ltd Promotion of synchronous sexual maturation and spawning in aquatic animals

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IN2015MN00403A (enExample) 2015-09-04
EP2887819A4 (en) 2016-04-06
IL237359A0 (en) 2015-04-30
US11344590B2 (en) 2022-05-31
CN108929855A (zh) 2018-12-04
US20180036357A1 (en) 2018-02-08
CA2882977C (en) 2019-05-21
EP2887819A1 (en) 2015-07-01
TR201814868T4 (tr) 2018-10-22
JP6275143B2 (ja) 2018-02-07
US9827280B2 (en) 2017-11-28
EP2887819B1 (en) 2018-07-25
CN104754954A (zh) 2015-07-01
JP2015531596A (ja) 2015-11-05
IL237359B (en) 2019-01-31
US20150164965A1 (en) 2015-06-18
CA2882977A1 (en) 2014-02-27
WO2014030165A1 (en) 2014-02-27

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