CN104740162A - Drug for treating streptococcus pneumonia syndrome of phlegm-heat obstructing lung and preparation method for drug - Google Patents

Abstract

The invention provides a drug for treating streptococcus pneumonia syndrome of phlegm-heat obstructing lung and a preparation method for the drug. The drug is prepared from the following raw herbal materials: radix asteris, poria cocos, snakegourd peel, pinellia ternate, platycodon grandiflorum, radix glycyrrhizae, cordate houttuynia, semen lepidii, mirabilite, lysimachia christinae hance, burdock, puerarin, radix scrophulariae, indigo naturalis, radix cudramiae, horse bezoar, oyster, pelvetia silquosa, sauropus spatulifolius, radix phlomii, umbilicaria esculenta, jersey cudweed, monocotyledoneae, duchesnea indica root and fine licorice root. With the principle of eliminating phlegm by cooling and effects of purging fire for removing toxin, clearing damp and promoting dieresis and purging fu-organs to eliminate heat, the drug is used for treating the streptococcus pneumonia syndrome of phlegm-heat obstructing lung, can be used for improving the immunity of people, and is purely natural and non-toxic in treating the streptococcus pneumonia syndrome of phlegm-heat obstructing lung, simple in preparation process, small in toxic or side effects, convenient to dose, relatively good in curative effect, relatively good in tolerance, easy to accept, easy to prepare and low in cost.

Description

A kind of medicine for the treatment of streptococcus pneumoniae property pneumonia syndrome of phlegm-heat obstructing lung with and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind ofly treating medicine of streptococcus pneumoniae property pneumonia syndrome of phlegm-heat obstructing lung and preparation method thereof.

Background technology

Pneumococcal pneumonia is the pneumonia caused by streptococcus pneumoniae or title streptococcus pneumoniae, accounts for the half of community acquired pneumonia.Usual onset is hurried, with high heat, shiver with cold, cough, bloody sputum and chest pain for feature.X-ray rabat is lung section or lobe of the lung acute inflammation consolidation.The pneumococcal pneumonia general four seasons are visible, but maximum with winter. primary disease is most commonly in age too little or too old patient. and pharyngeal bacterioscopy shows, the artificial pneumococcal bacillicarrier of health of 5% ~ 25%, winter child and father and mother's recall rate of child the highest. according to capsular polysaccharide antigen classification, streptococcus pneumoniae has the serotype of more than 80 kinds.

The cause of disease: streptococcus pneumoniae is Gram-positive coccus, be way double-line or short chain arrangement more.Except causing pneumonia, can there is bacteremia or septic shock in minority, and the state of an illness of old people and infant is particularly serious.Pneumococcal pneumonia with winter and the early spring common, patient is often original healthy person between twenty and fifty or less than 5 years old children's and more than 60 years old old man.In recent years due to the extensive use of antibacterials, clinically mild symptoms or the disease that is not true to type comparatively common.Children's prevents by vaccine.Current inoculable Pnu-Imune 23 has 7 valent pneumococcal conjugate vaccines and 23 valency pneumococcal polysaccharide vaccines, and within less than 2 years old, baby can only inoculate 7 valent pneumococcal conjugate vaccines.

Pathogenesis: streptococcus pneumoniae is generally by sucking, pulmonary is arrived through upper respiratory tract. they rest on bronchioles internal breeding and the process that causes inflammation, start the liquid producing a large amount of protein in alveolar space, this liquid plays a part Pathogen culture medium, and pathogenic bacteria can be helped to contiguous alveolar diffusion, typical result causes lobar pneumonia.The initial period of lobar pneumonia is congested, and feature is a large amount of serous effusions, and vasodilation and antibacterial breed rapidly.Next stage is called " red hepatization ", and namely the lungs of consolidation are liver sample outward appearance: air cavity is full of polymorphonuclear cell, the congestion of blood vessel and erythrocyte extravasation, and therefore macroscopy is pale red.Then be " gray hepatization " phase, the fibrin of this phase gathers relevant with the leukocyte and erythrocyte being in the different decomposition stage, and alveolar space is full of inflammatory exudate. and final stage take exudate absorption as dissipation phase of feature.

Clinical manifestation: symptom: premorbid is often suffered from cold, drench with rain, tired, excessive drinking, virus infection history, have upper respiratory tract infection more. prodrome, how hurried onset is, high heat, shiver with cold, muscular soreness of whole body, body temperature rises to 39 ~ 40 DEG C usually within a few hours, and peak is in the afternoon or at dusk, or in continued fever, rapid pulse is speedup thereupon.Can have Ipsilateral chest pain, emit to shoulder or abdominal part, cough or aggravation when deeply breathing, expectorant is few, can be with blood or rust, and stomach is received and fallen sharply, and occasionally has Nausea and vomiting, stomachache or diarrhoea, is easily misdiagnosed as acute abdomen.

Sign: patient is acute heat sickly complexion, and buccal is bright red, flaring of nares, skin burns, drying, there are simple born of the same parents' rash in bicker and nose week; Cyanosis can be there is when pathological changes is extensive.There is septicemia person, skin, mucosal bleeding point can be occurred, yellow sclera.Initial lung sign Non Apparent Abnormality, only have thorax respiratory movement amplitude to reduce, percussion is slightly turbid, and auscultation can have respiratory murmur to reduce and pleuritic rub.During pulmonary consolidation, dull percussion note, tactile fremitus strengthen and audible and bronchial breathing sound.Paracmasis audible and moist rale.Increased heart rate, sometimes arrhythmia.Patient with severe symptoms has intestinal tympanites, and epigastrium tenderness is how relevant with diaphragmatic pleura.Shock, adult respiratory distress syndrome and neuropsychic symptom can be accompanied during severe infection, show as in a certain state of delirium, irritated, dyspnea, drowsiness, delirium, stupor.There is stiff neck when involving meninges and occur pathologic reflex.The natural history of Pneumococcal pneumonia roughly 1 ~ 2 weeks.Fall ill 5 ~ 10 days, body temperature can rapid drawdown or disappear gradually voluntarily; Can make body temperature in 1 ~ 3 day, recover normal after using effective antibacterials.Other symptom of patient and sign also disappear thereupon.

Diagnosis: all febris acuta companion chest pains, dyspnea and cough all should be suspected for streptococcus pneumoniae property pneumonia.According to medical history, chest x-ray changes, and the cultivation of suitable specimen and Gram’s staining, capsule swelling reaction can make tentative diagnosis.Definite diagnosis then needs to prove Pleural fluid, blood, lung tissue or have streptococcus pneumoniae in tracheal aspirate, x-ray rabat.

Treatment: to the streptococcus pneumoniae strain of penicillin-susceptible, benzylpenicillin is choice drug.Non-patient with severe symptoms can oral benzylpenicillin or V250 ~ 500mg, every 6 hours 1 time.Recommend to give aqueous penicillin G50 ~ 2,000,000 u intravenous injections, every 4 ~ 6 hours 1 time to uncomplicated pneumococcal pneumonia.

The streptococcus pneumoniae of about 25% is to Penicillin-resistant.In the U.S., in the bacterial strain be separated clinically, penicillin relatively or height resistant rate be 15% ~ 30%, and in other regions of the world, particularly Spain, Japan, Israel, South Africa and West Europe, resistant rate is higher.Many Penicillin-resistant bacterial strains are to the same drug resistance of other antibiotic.Plate containing 1 μ g benzylpencilline is applicable to detect Resistant strain.The separator of inhibition zone≤19mm should adopt broth dilution agent to detect again.To the treatment of height Resistant strain, should according to drug sensitivity testing in vitro.High dose penicillin, cefotaxime or ceftriaxone effective to most of Resistant strain.A new generation's quinolones (levofloxacin, Sparfloxacin, grepafloxacin and trovafloxacin) is the medicine often selected of Penicillin-resistant bacterial strain, also can be the medicine of Gong the replacement of penicillin-sensitive strains treatment.Vancomycin, as unique a kind of medicine with long-lasting activity, all has antibacterial activity to all streptococcus pneumoniae, can be used as in most of the cases with the choice drug of the patient with severe symptoms of high penicillin resistant incidence rate.

Other effective medicines comprise cephamycin class, erythromycin and clindamycin.The reliability of tetracycline anti-streptococcus pneumoniae effect is poor, and the patient be in a bad way should not use.Oral medication comprises erythromycin or lincomycin 300mg, every 6 hours 1 time.Parental administration comprises cefotaxime 1 ~ 2g intravenous injection, every 6 hours 1 time; Ceftriaxone 1 ~ 2g intravenous injection, every 12 hours 1 time; Cefazolin sodium 500mg intravenous injection, every 8 hours 1 time, erythromycin 0.5 ~ 1g intravenous injection, every 6 hours 1 time; Or clindamycin 300 ~ 600mg intravenous injection, every 6 ~ 8 hours 1 time. except cefotaxime and ceftriaxone, most of third generation cephamycin is relative to antibacterial activity to streptococcus pneumoniae.

During as being suspected to have meningitis, patient should give cefotaxime 2g intravenous injection, every 4 ~ 6 hours 1 time or ceftriaxone 1 ~ 2g intravenous injection, every 12 hours 1 time, give vancomycin 1g intravenous injection, every 12 hours 1 time simultaneously, add with or do not add with rifampicin 600mg/d oral, until know drug sensitivity tests.To patients with empyema, except giving antibiotic, treatment should comprise suitable drain.

Supporting Therapy comprises and lying up, liquid make-up and use analgesic for pleura pain.Have cyanosis, obvious anoxia, severe dyspnea, the patient of disturbance of circulation or delirium answers oxygen supply.Constantly vim and vigour will be checked, especially to the patient of chronic lung disease during oxygen therapy.

General opinion follows up a case by regular visits to x-ray inspection to the patient of more than 35 years old.Chest X-ray just can see infiltrate resolves possibly after a few week, is in a bad way and has the patient of bacteremia or original existing chronic lung disease especially true.Within more than 6 weeks or 6 weeks, still there is infiltration after treatment starts, show to have constitutional bronchus neoplasm or TB.

Chinese medical discrimination: 1, syndrome of phlegm-heat obstructing lung, syndrome: cough, expectoration usually can be thick or cough rusty expectoration with Huang, and breathe tachypnea, hyperpyrexia, chest and diaphragm feeling of fullness, the pain of pressing, thirsty agitation, yellowish or reddish urine, is hard and dry, red tongue with yellow fur, full and rapid pulse or sliding number.2, heat-blockage mind card, syndrome: cough tachypnea, the rumbling of expectorant sound, irritated, unconsciousness and delirium, hyperpyrexia, very then extreme cold of the limbs, deep red tongue, yellow fur and doing, thready,rolling and rapid pulse.3, attack of pathogenic warmth in the lung, card is shown in unconsciousness due to high fever, and dryness in the nasal cavity is without tears, and hacking cough is expectorant less, yellow and thin fur, full and rapid pulse.4, pathogenic dryness impairing the lung, card is shown in that lip, tongue, nose are all dry, the few expectorant of dry cough, and expectorant is sticky to be difficult to bring up, and pharyngodynia with dryness is thirsty, red tongue, rapid pulse.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of and treat medicine of streptococcus pneumoniae property pneumonia syndrome of phlegm-heat obstructing lung and preparation method thereof, this medicine take removing heat-phlegm as principle, holds concurrently with eliminating fire and detoxication, promoting diuresis to eliminate damp pathogen, eliminating heat pathogen by purging the bowels.Treatment streptococcus pneumoniae property pneumonia syndrome of phlegm-heat obstructing lung has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.

For solving the problems of the technologies described above, the invention provides a kind of medicine for the treatment of streptococcus pneumoniae property pneumonia syndrome of phlegm-heat obstructing lung, wherein, described medicine comprises following raw medicinal material: described medicine is obtained by following raw medicinal material: Radix Asteris, Poria, Pericarpium Trichosanthis, the Rhizoma Pinelliae, Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Semen Lepidii (Semen Descurainiae), Natrii Sulfas, Herba Lysimachiae, Fructus Arctii, Radix Puerariae, Radix Scrophulariae, Indigo Naturalis, Radix Cudraniae, Calculus Equi, Concha Ostreae, Pelvetia siliquosa Tseng et C. F. Chang, Folium Sauropi, Radix phlomidis younghusbandii, Umbillcaria esculenta, swamp cudweed, Folium rumicis acetosae, Radix duchesneae indicae, Radix Glycyrrhizae uralensis.

Wherein, described medicine is obtained by the raw medicinal material of following parts by weight: Radix Asteris 30-40 weight portion, Poria 2-5 weight portion, Pericarpium Trichosanthis 15-20 weight portion, Rhizoma Pinelliae 4-7 weight portion, Radix Platycodonis 20-30 weight portion, Radix Glycyrrhizae 30-40 weight portion, Herba Houttuyniae 6-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-15 weight portion, Natrii Sulfas 4-6 weight portion, Herba Lysimachiae 10-20 weight portion, Fructus Arctii 20-30 weight portion, Radix Puerariae 8-13 weight portion, Radix Scrophulariae 10-14 weight portion, Indigo Naturalis 8-13 weight portion, Radix Cudraniae 20-30 weight portion, Calculus Equi 3-7 weight portion, Concha Ostreae 10-20 weight portion, Pelvetia siliquosa Tseng et C. F. Chang 4-7 weight portion, Folium Sauropi 15-20 weight portion, Radix phlomidis younghusbandii 12-24 weight portion, Umbillcaria esculenta 10-20 weight portion, swamp cudweed 15-20 weight portion, Folium rumicis acetosae 20-30 weight portion, Radix duchesneae indicae 13-24 weight portion, Radix Glycyrrhizae uralensis 20-30 weight portion.

Wherein, also Eugenia javanica Lam is comprised, Herba lychnidis coronatae, Folium Mahoniae, Herba Epilobii Angustifoii, tongue spray, described medicine is obtained by the raw medicinal material of following parts by weight: Radix Asteris 30-40 weight portion, Poria 2-5 weight portion, Pericarpium Trichosanthis 15-20 weight portion, Rhizoma Pinelliae 4-7 weight portion, Radix Platycodonis 20-30 weight portion, Radix Glycyrrhizae 30-40 weight portion, Herba Houttuyniae 6-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-15 weight portion, Natrii Sulfas 4-6 weight portion, Herba Lysimachiae 10-20 weight portion, Fructus Arctii 20-30 weight portion, Radix Puerariae 8-13 weight portion, Radix Scrophulariae 10-14 weight portion, Indigo Naturalis 8-13 weight portion, Radix Cudraniae 20-30 weight portion, Calculus Equi 3-7 weight portion, Concha Ostreae 10-20 weight portion, Pelvetia siliquosa Tseng et C. F. Chang 4-7 weight portion, Folium Sauropi 15-20 weight portion, Radix phlomidis younghusbandii 12-24 weight portion, Umbillcaria esculenta 10-20 weight portion, swamp cudweed 15-20 weight portion, Folium rumicis acetosae 20-30 weight portion, Radix duchesneae indicae 13-24 weight portion, Radix Glycyrrhizae uralensis 20-30 weight portion, Eugenia javanica Lam 10-20 weight portion, Herba lychnidis coronatae 25-30 weight portion, Folium Mahoniae 10-20 weight portion, Herba Epilobii Angustifoii 12-24 weight portion, tongue spray 20-30 weight portion.

Wherein, described medicine is obtained by the raw medicinal material of following parts by weight: Radix Asteris 35 weight portion, Poria 3 weight portion, Pericarpium Trichosanthis 16 weight portion, the Rhizoma Pinelliae 5 weight portion, Radix Platycodonis 25 weight portion, Radix Glycyrrhizae 35 weight portion, Herba Houttuyniae 8 weight portion, Semen Lepidii (Semen Descurainiae) 12 weight portion, Natrii Sulfas 5 weight portion, Herba Lysimachiae 15 weight portion, Fructus Arctii 25 weight portion, Radix Puerariae 9 weight portion, Radix Scrophulariae 12 weight portion, Indigo Naturalis 9 weight portion, Radix Cudraniae 25 weight portion, Calculus Equi 5 weight portion, Concha Ostreae 15 weight portion, Pelvetia siliquosa Tseng et C. F. Chang 6 weight portion, Folium Sauropi 16 weight portion, Radix phlomidis younghusbandii 18 weight portion, Umbillcaria esculenta 15 weight portion, swamp cudweed 17 weight portion, Folium rumicis acetosae 25 weight portion, Radix duchesneae indicae 18 weight portion, Radix Glycyrrhizae uralensis 26 weight portion.

Wherein, described medicine is obtained by the raw medicinal material of following parts by weight: Radix Asteris 35 weight portion, Poria 3 weight portion, Pericarpium Trichosanthis 16 weight portion, the Rhizoma Pinelliae 5 weight portion, Radix Platycodonis 25 weight portion, Radix Glycyrrhizae 35 weight portion, Herba Houttuyniae 8 weight portion, Semen Lepidii (Semen Descurainiae) 12 weight portion, Natrii Sulfas 5 weight portion, Herba Lysimachiae 15 weight portion, Fructus Arctii 25 weight portion, Radix Puerariae 9 weight portion, Radix Scrophulariae 12 weight portion, Indigo Naturalis 9 weight portion, Radix Cudraniae 25 weight portion, Calculus Equi 5 weight portion, Concha Ostreae 15 weight portion, Pelvetia siliquosa Tseng et C. F. Chang 6 weight portion, Folium Sauropi 16 weight portion, Radix phlomidis younghusbandii 18 weight portion, Umbillcaria esculenta 15 weight portion, swamp cudweed 17 weight portion, Folium rumicis acetosae 25 weight portion, Radix duchesneae indicae 18 weight portion, Radix Glycyrrhizae uralensis 26 weight portion, Eugenia javanica Lam 15 weight portion, Herba lychnidis coronatae 26 weight portion, Folium Mahoniae 15 weight portion, Herba Epilobii Angustifoii 17 weight portion, tongue spray 24 weight portion.

In order to solve the problems of the technologies described above, present invention also offers a kind of preparation method of described medicine, wherein, the dosage form of described medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 350 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.05 ~ 0.3:0.05 ~ 0.2, incapsulate in housing, obtain capsule by described capsule 's content.

Wherein, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 350 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.01 ~ 0.12 times of lactose, the starch of 0.01 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.001 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Wherein, the dosage form of described medicine is injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 96%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 45 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 20g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

The invention has the beneficial effects as follows: medicine of the present invention, take removing heat-phlegm as principle, holds concurrently with eliminating fire and detoxication, promoting diuresis to eliminate damp pathogen, eliminating heat pathogen by purging the bowels.Treatment streptococcus pneumoniae property pneumonia syndrome of phlegm-heat obstructing lung has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.

Detailed description of the invention

We are principle with removing heat-phlegm, hold concurrently with eliminating fire and detoxication, promoting diuresis to eliminate damp pathogen, eliminating heat pathogen by purging the bowels.For primary treatment pneumococcal pneumonia, select Radix Asteris, Poria, Pericarpium Trichosanthis, the Rhizoma Pinelliae, Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Semen Lepidii (Semen Descurainiae), Natrii Sulfas, Herba Lysimachiae, Fructus Arctii, Radix Puerariae, Radix Scrophulariae, Indigo Naturalis, Radix Cudraniae, Calculus Equi, Concha Ostreae, Pelvetia siliquosa Tseng et C. F. Chang, Folium Sauropi, Radix phlomidis younghusbandii, Umbillcaria esculenta, swamp cudweed, Folium rumicis acetosae, Radix duchesneae indicae, Radix Glycyrrhizae uralensis.Also comprise Eugenia javanica Lam, Herba lychnidis coronatae, Folium Mahoniae, Herba Epilobii Angustifoii, tongue spray.

Wherein Pericarpium Trichosanthis, Herba Houttuyniae, Herba Lysimachiae, the Rhizoma Pinelliae, Radix Cudraniae, Calculus Equi, Concha Ostreae, Pelvetia siliquosa Tseng et C. F. Chang, Folium Sauropi, Radix phlomidis younghusbandii, Umbillcaria esculenta, swamp cudweed heat clearing and damp drying are reduced phlegm; Radix duchesneae indicae, Radix Glycyrrhizae uralensis clearing away heat-fire; Radix Asteris, Semen Lepidii (Semen Descurainiae), lowering the adverse-rising QI to subdue asthma; Poria, Herba Houttuyniae, Semen Lepidii (Semen Descurainiae), Herba Lysimachiae, promoting diuresis to eliminate damp pathogen; Herba Houttuyniae, Herba Lysimachiae, Indigo Naturalis, heat-clearing and toxic substances removing; Eugenia javanica Lam, Herba lychnidis coronatae, Folium Mahoniae eliminating fire and detoxication; Radix Platycodonis, Radix Glycyrrhizae reduce phlegm evacuation of pus; Folium rumicis acetosae, Natrii Sulfas, Fructus Arctii eliminating heat pathogen by purging the bowels; Herba Epilobii Angustifoii, tongue spray promoting diuresis to eliminate damp pathogen; Radix Trichosanthis, Radix Puerariae, Radix Scrophulariae help lung expectoration.Many medical material scientific compatibility, disease therapy, reaches drug effect.

Now each taste medicine is described below:

Radix Asteris: warm in nature, bitter in the mouth, pungent.Nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.Cure mainly cough, deficiency of the lung chronic cough, consumptive lung disease lung abscess, coughs vomiting bloody pus, dysuria.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.Be used for the treatment of chronic cough asthma.From Radix Asteris, isolated epifriedelanol has certain antitumaous effect to ehrlich carcinoma, anesthetized rabbit gavages decoct 1 g/kg, have remarkable phlegm-dispelling functions (respiratory tract secretory volume algoscopy), act on sustainable more than 4 hours, crude extract is oral also to be had significantly increasing action rat trachea secretions.In vitro tests has certain inhibitory action to escherichia coli, dysentery bacterium (Song Nei Shi), Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus and vibrio cholera etc.

Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid." modern study shows that the effect that Poria has an enhancing immunity can many-sided regulate immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.

Pericarpium Trichosanthis: nature and flavor are sweet, bitter, cold.Enter lung, stomach, large intestine channel.Clearing away heat and eliminating phlegm, the relieving constipation of lung moistening eliminating stagnation.Compendium of Material Medica is said: " lung moistening is dry, pathogenic fire reducing.Control cough, clearing away phlegm is tied, throat, subduing inflammation sore." " book on Chinese herbal medicine is just read " record: " and Fructus Trichosanthis, nature and flavor are identical with pollen, only the profit merits and demerits of falling it.Therefore all stagnation of heat in upper-JIAOs, the cards such as dirty greasy phlegm-fire cough, all can use it.The fiery person of genus of all lung abscess, acute appendicitis, acute mastitis, particularly suitable." function cures mainly: lung moistening, reduce phlegm, eliminating stagnation, intestine moistening.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of.

The Rhizoma Pinelliae: its acrid in the mouth, warm in nature; Return spleen, stomach, lung meridian.Function drying dampness to eliminate phlegm, and middle stomach invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, external can reducing swelling and alleviating pain.Can be used for expectorant damp-phlegm rare and many clearly, cold-phlegm, often join Pericarpium Citri Reticulatae.Due to Rhizoma Pinelliae strong toxicity, after concocting, toxicity can weaken, suitable for oral administration.

Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mending five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." herbal classic " is said: " main chest and hypochondrium as lancination, abdominal distention, borborygmus are faint, gas of throbbing with fear in terror "." Japan hanako materia medica " is said: " mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant for all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, broken lump in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat ".Modern pharmacological research shows, Radix Platycodonis has and eliminates the phlegm and antitussive effect; Hypoglycemic activity; Suppress gastric secretion and antiulcer action; Antiinflammatory action; Calmness, analgesia and refrigeration function.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian.Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.

Herba Houttuyniae: cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.There is heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; The function of inducing diuresis for treating stranguria syndrome.Cure mainly the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.Modern multiplexly control lung abscess, pneumonia, acute and chronic tracheitis, urinary tract infection etc.Modern pharmacology experiment shows, these product have the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Clinical report is widely used in treatment pneumonia, spitting of blood, upper respiratory tract infection, chronic bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, pulmonary carcinoma, cervical erosion, suppurative arthritis, habitual constipation, acute bacillary dysentery, acute icterohepatitisshock, nephrotic syndrome, herpes simplex keratitis, rhinitis, suppurative otitis media, mumps, pimple shape urticaria, chronic pharyngitis, anorectal disease, prostatitis, lupus erythematosus, hemangioma, prevention leptospirosis etc.

Semen Lepidii (Semen Descurainiae): pungent, bitter, cold; Return lung meridian, heart channel, Liver Channel, stomach warp, urinary bladder channel.Function eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma, inducing diuresis to remove edema, lets out by heresy.Cure mainly sputum stop up the dyspnea and cough with excessive sputum of lung, lung abscess, edema, breast abdomen hydrops, dysuria, chronic pulmonary heart disease, heart failure breathe heavily swollen, scrofula tuberculosis." Mingyi Bielu ": " lower bladder water, volt stays steam, between skin evil waterborne go out, the edema of the face, the sudden and violent apoplexy miliaria alba of body is itched, sharp lower abdomen." " Kaibao Bencao ": " treatment lung stops up upper gas cough, and Dingchuan is urged, and removes phlegm retention in the heart." alcohol extract of dry seed of descurainia sophia (l.) webb ex prantl, bird's-pepper (pl. bird's-peppers) and semolina; all apparent cardiotonic; can make it to stop at systole to the frog heart in place, rabbit in place, the cat heart, cat heart-lung apparatus; the researchs such as cat electrocardiogram; all make the heart shrink and strengthen, decreased heart rate, heart-block; output can be increased to the heart of exhaustion, reduce venous pressure.

Natrii Sulfas: salty, bitter, cold.Return stomach warp; Lung meridian; Spleen channel; Kidney channel; Small intestine meridian; Tri-jiao channel; Large intestine channel.Purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.For excess-heat constipation, constipation due to dry stool, stagnant stomachache, acute appendicitis swells and ache; External treatment acute mastitis, swelling and pain of hemorrhoid.Indication: 1. for constipation, enteral abnormal fermentation, also can use with anthelmintic; Share with active carbon, food or drug intoxication can be treated.2. for obstructive jaundice and chronic cholecystitis.3. for convulsions, eclamposia, uremia, tetanus, hypertensive encephalopathy and acut renal hypertension crisis etc.4. the Patients With Angina Pectoris that also other treatment effect is bad for showing effect frequently, to better with hypertensive patient's effect.5. external hot compress, antiinflammatory goes to swell.

Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature; Return liver, gallbladder, kidney, urinary bladder channel.Function relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus, pyretic stranguria, oedema due to nephritis, jaundice due to damp-heat, sore carbuncle, venom, traumatic injury.Herba Lysimachiae has good dampness removing jaundice eliminating and the treating stranguria effect of calculus, treating the liver cholelithiasis and jaundice, can decoct soup for tea-drinking by these product alone, or compatibility Herba Artemisiae Scopariae, Radix Curcumae, Radix Et Rhizoma Rhei etc. is to strengthen clearing liver-gallbladder and calculus effect.In addition, Herba Lysimachiae is used for edema, tympanites, and merit for oral administration, external application all has inducing diuresis to remove edema, for cough due to lung-heat, infantile hyperpyrexia gets its antipyretic and antidote functions.Modern study, these product are mainly containing phenolic constituent and sterol, flavonoid, aminoacid, tannin, volatile oil, choline, potassium salt etc., and also have calculus, antibacterial, antiinflammatory action, all has inhibitory action to humoral immunization, cellular immunization.

Fructus Arctii: acrid in the mouth, hardship, cold in nature.Attach to the lung and stomach meridians.Can dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, lung qi dispersing sore-throat relieving loose swollen.Cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; Sore swollen toxin and mumps etc.Raw with can loosening bowel to relieve constipation, pyretic toxicity red swelling and pain of throat, has constipation with heat retention concurrently especially suitable." Bencao Jingshu " is said: " dislike real, for loose wind is except the key medicine of thermal detoxification.Pungent can eliminating stagnation, hardship can expel the heat-evil, and the loose then visceral-qi of accumulation of heat is clear and bright, therefore improving eyesight and invigorating middle warmer.The institute of wind hinders, and defending gas must stop up, stop up then generate heat, Xin Liang dismiss then show gas and, wind without stay.Hide the swollen all flaccidity of device main air poison; The main lung moistening of element, eliminating stagnation gas, sore-throat relieving diaphragm, peeling skin wind, logical twelve channels and collaterals person, know this meaning ear.Therefore in order to control urticaria, variola, especially obtain and very test ".

Radix Puerariae: cool in nature, sweet in the mouth, pungent, enter spleen, stomach warp.Can yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.The famous physician's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty has carried out systematic research to Radix Puerariae, think the stem of Radix Puerariae, leaf, flower, really, root all can be used as medicine.He records like this in Compendium of Material Medica: " Pueraria lobota, property is sweet, pungent, flat, nontoxic, cures mainly: quench one's thirst, high fever of the body, vomiting, all frauds, cloudy gas, separates all poison ".

Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel.Clearing away heat-fire, YIN nourishing and the production of body fluid promoting." detailed outline ": " kidney water is injured, Kidney-Yin fall, lonely positive unrooted, and send out as fire is sick, method should strengthen water with fire processed, therefore Radix Scrophulariae and the same merit of Radix Rehmanniae.Its scrofula that disappears also is loose fire, and it is that fire is sick that Liu keeps the truth tuberculosis." " Records of Tradition Chinese and Western Medicine in Combination ": " many liquid cool in nature was the medicine of the kidney invigorating warp clearly originally for Radix Scrophulariae, sweet and slightly bitter taste.Can enter again lung with the bright heat of lung heat clearing man, removing toxic substances quench, is suitable for pneumonopathy tuberculosis most, cough due to lung-heat.”

Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, there is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms are sent out for epidemic febrile disease, Indigo Naturalis, containing indigo, indirubin, has the antiviral effect of heat-clearing and toxic substances removing, sore, inhibited to cholera bacilli, Bacillus typhi, dysentery bacterium and fractionated viral.

Radix Cudraniae: [nature and flavor] light micro-hardship is cool.1. " the SHENGCAO property of medicine is standby to be wanted ": " taste is sweet, and property is put down." 2. " east, Fujian book on Chinese herbal medicine ": " sweet in the mouth, warm in nature." 3. Guangzhou army " conventional Chinese herbal medicine handbook ": " light micro-hardship, micro-cool." 4. " the practical Chinese herbal medicine in Guangxi newly selects ": " micro-hardship is micro-sweet, and property is put down, nontoxic." 5. " choosing of Yunnan Chinese herbal medicine ": " is light micro-sweet, cool." [function cures mainly] expelling wind and removing dampness, promoting blood circulation to restore menstrual flow.Dispelling the wind and dampness pathogens arthralgia, jaundice, stranguria with turbid discharge, distention of the abdomen caused by various parasites, amenorrhea, impairment caused by overstrain hemoptysis, traumatic injury, furuncle carbuncle.1. Yao can become " food book on Chinese herbal medicine ": " control skin infection scabies." 2. " the SHENGCAO property of medicine is standby to be wanted ": " controls wine top, and disappear distention of the abdomen caused by various parasites; Infusing drugs in wine dispels the wind." 3. " book on Chinese herbal medicine asks former ": " strengthening bone and muscle, invigorates blood circulation, reason traumatic injury." 4. " south of the Five Ridges gather medicinal herbs record ": " wind-damp dispelling, ten steam nine shines; Control traumatic injury, wine decoction; Shoulder skin ulcer and honey are smash deposited." 5. " Nanning City's medicine will ": " blood stimulates the menstrual flow, and controls stranguria with turbid discharge, goes long-pending, the calculus of the many years ago stasis of blood." 6. " east, Fujian book on Chinese herbal medicine ": " invigorating spleen and reinforcing stomach, relaxing muscles and tendons and activating QI and blood in the collateral, wind-damp dispelling, blood stasis removing blood.Control lumbago, arthralgia, asthenia general edema with yellowish skin, diarrhea due to hypofunction of the spleen." 7. Guangzhou army " conventional Chinese herbal medicine handbook ": " cool the blood dissipate blood stasis.Control amenorrhea." 8. " the practical Chinese herbal medicine in Guangxi newly selects ": " heat clearing and blood circulation promoting, eliminating phlegm and stopping cough, controls impairment caused by overstrain hemoptysis." 9. " choosing of Yunnan Chinese herbal medicine ": " anti-inflammatory analgetic, controls mumps, furuncle and phyma." 10. " Fujian Chinese herbal medicine ": " clearing away heat-damp and promoting diuresis.Control jaundice due to damp-heat, damp-heat arthralgia, furuncle carbuncle."

Calculus Equi: property sweet-salty is cool.1. " detailed outline ": " sweet salty, flat, nontoxic." 2. " Chinese medicinal herbal ": " sweet salty micro-hardship, cool." 3. " Traditional Chinese Medicine in Sichuan will ": " is cool in nature, and the micro-hardship of salty in the mouth is slightly poisonous." [return through] " Traditional Chinese Medicine in Sichuan will ": " enters the heart, liver two warp." [function cures mainly] is relieving convulsion reduces phlegm, heat-clearing and toxic substances removing.Control infantile convulsion demented, expectorant Re Neisheng, coma, hematemesis and epistaxis, malignant boil toxic swelling.1. " detailed outline ": " control infantile convulsion, skin infection." 2. " decoction pieces is newly joined ": " disappear liver brain, and heat-transformation expectorant, controls convulsion epilepsy, and emesis is defeated in battle." 3. " modern Practical Chinese medicinal ": " is effective for diseases such as nerve insomnia, hysteria, spasmodic coughs.And can detoxify, treatment of smallpox skin ulcer danger disease."

Concha Ostreae: [nature and flavor] are salty wet, cool.1. " herbal classic ": " salty in the mouth is flat." 2. " not Lu ": " be slightly cold, nontoxic." 3. " book on Chinese herbal medicine just ": " taste is micro-salty micro-puckery, and gas is put down." [return through] enters liver, kidney channel.1. Materia Medica of Decoction: " enter meridian of Foot-SHAO YIN." 2. " Bencao Jingshu ": " enters the few the moon of foot, the moon of fainting, shaoyang channel." hidroschesis, arresting seminal emission, reduces phlegm, softening the hard mass for [function cures mainly] yin fluid astringing, YANG hyperactivity suppressing.Control infantile convulsion, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.

Pelvetia siliquosa Tseng et C. F. Chang: [nature and flavor] are salty, cold.1. " health preserving will collect ": " salty in the mouth, cold profit." 2. the Meng numerous: " micro-poison." 3. " detailed outline ": " is sweet, Great Cold, sliding, nontoxic." [function cures mainly] heat clearing away, helps digestion, reduces phlegm.Control consumptive fever, expectorant is tied, mass in the abdomen, haemorrhoids.1. " feeding habits book on Chinese herbal medicine ": " lower hot blast gas, treats the hot labor of children's's hectic fever due to YIN-deficiency." 2. " Japan hanako materia medica ": " separates fever sensation of the face.Eat under " 3. " south of the Five Ridges gather medicinal herbs record ": " expectorant.Control all expectorant knot mass in the abdomen, hemorrhoid poison.With make marine alga wine, control goiter; With make amber candy, go part of the body cavity above the diaphragm housing the heart and lungs superficial heat."

Folium Sauropi: the leaf of [source] Euphorbiaceae Sauropus plant Folium Sauropi Sauropus rostrata Miq..The whole year can adopt, or the autumn in summer gathers, and dries.[nature and flavor] are sweet, light, flat.[function cures mainly] removing heat-phlegm, lung moistening relieving constipation.For xeropulmonary cough, spitting of blood, constipation.

Radix phlomidis younghusbandii: ecological environment: be born in the dry hillside of height above sea level 4300-4600m, shrubbery and field.Resource distribution: be distributed in aldehyde health Ba Zong.[character] character identification tuber is irregular spherical or oblong, long 3-8cm, diameter 1-3cm.Surface yellow or yellowish-brown, have vertical wrinkle or obviously take out ditch; Two ends slightly projection become point, have radicula and root trace; Light weight is crisp, section white, mealiness.Feeble QI, taste is sweet.Be good with individual large, full, the more real person of matter.[nature and flavor] sweet in the mouth; Property is put down.[function cures mainly] wind and heat dispersing; Relieving cough and resolving phlegm; Promoting tissue regeneration and ulcer healing.Main anemopyretic cold; Cough with copious phlegm; Skin infection is burst for a long time and is not held back.

Umbillcaria esculenta: lichens Umbilicariaceae Umbilcaria plant Umbillcaria esculenta Gyrophora esculenta Miyshi, is used as medicine with thallus.The four seasons can adopt, and dry.[nature and flavor] are sweet, flat.[function cures mainly] clearing away heat to stop bleeding, relieving cough and resolving phlegm.For spitting blood, epistaxis, metrorrhagia, cystitis, enteritis, dysentery, bronchitis.Venom is controlled in external, burn and scald.

Swamp cudweed: [nature and flavor] are " Chinese herbal medicine handbook is commonly used in northeast " 1.: " sweet, flat." 2. " plateau Chinese herbal treatment handbook ": " is sweet, is slightly cold." [return through] " plateau Chinese herbal treatment handbook ": " enters lung, intestine and small intestine warp.", in tune, blood pressure lowering, the skin ulcer that disappears swells for [function cures mainly] relieving cough and resolving phlegm, damp eliminating.Control cough and asthma, bones and muscles pain, hygropyretic dysentery, gastric ulcer, hypertension, carbuncle pyogenic infections from tumour or sore.1. " will planted by northeast medicine ": " relieving cough and resolving phlegm.Control asthma and bronchitis, gastric ulcer, hypertension, burn, abscess.QI invigorating in " 2. " Chinese herbal medicine handbook is commonly used in northeast ": " tune, relieving cough and resolving phlegm." 3. " the conventional Chinese herbal medicine handbook in the north ": " controls dysmenorrhea." 4. " plateau Chinese herbal treatment handbook ": " controls laryngopharynx swelling and pain, tuberculosis pneumonia, in vain red under dysentery, carbuncle pyogenic infections from tumour or sore."

Folium rumicis acetosae: [nature and flavor] acid; Micro-hardship; Cold in nature.[function cures mainly] expels the heat-evil logical secret; Diuresis; Cooling blood for hemostasis; Removing toxic substances.Main constipation; Dysuria; Internal hemorrhoid hemorrhage; Skin infection; Erysipelas; Scabies; Eczema; Scald.

Radix duchesneae indicae: ecological environment: be born in hillside, riverbank, meadow, moist place.Resource distribution: be distributed in various places on the south Liaoning.[nature and flavor] are bitter, sweet; Cold.[return through] lung; Liver; Stomach warp.[function cures mainly] clearing away heat-fire; Removing toxic substances and promoting subsidence of swelling.Main calentura, water infantile convulsion, conjunctival congestion is red and swollen, mumps, gingival swelling and pain, laryngopharynx swelling and pain, pathopyretic ulcer.

Radix Glycyrrhizae uralensis: ecological environment: be 1. born in the dry ground such as calcareous grassland, riverbank sandy soil on the sunny side.2. this kind originates in European mediterranean region, and also there is growth in north African, middle Asia and Siberia, and Xinjiang of China also has distribution, and can be born in the saline alkali wasteland of arid.3. be born in sandy.Resource distribution: be 1. distributed in the ground such as northeast, North China, northwest.2. be distributed in the ground such as Gansu, Xinjiang.[nature and flavor] are sweet; Cold [return through] heart; Liver; Spleen channel [function cures mainly] eliminating fire and detoxication; Inducing diuresis for treating stranguria syndrome.Main pyretic stranguria; Oliguria; Pain in penis; Accumulated heat in the heart.

Eugenia javanica Lam: there is cultivation in [habitats distribution] Guangdong, Taiwan and Guangxi.Originate in Malaysia and India.[nature and flavor] bitter in the mouth; Cold in nature.[return through] GUIXIN; Liver Channel.[function cures mainly] eliminating fire and detoxication; Dampness removing to stop itchin.Main aphtha of the mouth and tongue; Thrush; Skin infection wets rotten; Pudendal pruritus.

Herba lychnidis coronatae: [nature and flavor] are sweet; Micro-hardship; Cold in nature.[return through] lung; Liver Channel.[function cures mainly] removing damp-heat; Eliminating fire and detoxication.Main cold, fever; Herpes zoster; Rheumatic arthralgia; Have loose bowels.

Folium Mahoniae: nature and flavor " decoction pieces is newly joined ": " bitter, cool." [return through] " book on Chinese herbal medicine is new again ": " enters lung meridian." [function cures mainly] heat clearing away tonify deficiency, relieving cough and resolving phlegm.Control pulmonary tuberculosis hemoptysis, osteopyrexia and fever, dizziness and tinnitus, waist soreness, vexed, conjunctival congestion.1. " book on Chinese herbal medicine is new again ": " control cough due to consumptive disease." 2. " Zhiwu Mingshi Tukao ": " controls haematemesis." 3. " decoction pieces is newly joined ": " controls impairment of the lung caused by overstrain, relieving cough and resolving phlegm, reducing the asthenic fever, parasite killing." 4. " modern Practical Chinese medicinal ": " cooling nourishing antasthenic.Effect is similar to Fructus Ligustri Lucidi, is applicable to the cards such as hectic fever, hectic fever due to YIN-deficiency, the soreness of waist, knee joint are soft, dizzy, tinnitus." 5. " Luchuan book on Chinese herbal medicine ": " pathogenic fire purging is brought down a fever.Control epidemic febrile disease heating, vexed, lower profit, acute conjunctivitis." 6. " Chinese herbal medicine is commonly used in Tibet ": " controls hygropyretic dysentery, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus."

Herba Epilobii Angustifoii: [nature and flavor] bitter in the mouth; Property is put down.[function cures mainly] promoting diuresis to eliminate damp pathogen; To regulate the flow of vital energy relieving distension; Promoting blood flow to regulate menstruation.Main edema; Have loose bowels; Food stagnation distension; Menoxenia; Galactostasis; Scrotum enlargement; Skin ulcer rash is itched bitterly.

Tongue spray: Urticaceae Pilea plant tongue spray Pilea japonica (Maxim.) Hand.-Mazz., with all herbal medicine.Xia Qiucai, cleans and dries, or using fresh herb.[nature and flavor] are sweet, cool.[function cures mainly] heat-clearing and toxic substances removing, eliminating dampness by diuresis diuresis.For tonsillitis, urinary tract infection, cervicitis, leucorrhea with red and white discharge.

Preferably, described medicine is only made up of above-mentioned raw materials medical material.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 capsule

Radix Asteris 35 parts, 3 parts, Poria, Pericarpium Trichosanthis 16 parts, the Rhizoma Pinelliae 5 parts, Radix Platycodonis 25 parts, 35 parts, Radix Glycyrrhizae, Herba Houttuyniae 8 parts, Semen Lepidii (Semen Descurainiae) 12 parts, 5 parts, Natrii Sulfas, Herba Lysimachiae 15 parts, Fructus Arctii 25 parts, Radix Puerariae 9 parts, Radix Scrophulariae 12 parts, Indigo Naturalis 9 parts, Radix Cudraniae 25 parts, Calculus Equi 5 parts, Concha Ostreae 15 parts, Pelvetia siliquosa Tseng et C. F. Chang 6 parts, Folium Sauropi 16 parts, Radix phlomidis younghusbandii 18 parts, Umbillcaria esculenta 15 parts, swamp cudweed 17 parts, Folium rumicis acetosae 25 parts, Radix duchesneae indicae 18 parts, Radix Glycyrrhizae uralensis 26 parts.

Its preparation method is:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 80%, reflux 1 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 350 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.05:0.05, incapsulate in housing, obtain capsule by described capsule 's content.

Embodiment 2 tablet

Radix Asteris 35 parts, 3 parts, Poria, Pericarpium Trichosanthis 16 parts, the Rhizoma Pinelliae 5 parts, Radix Platycodonis 25 parts, 35 parts, Radix Glycyrrhizae, Herba Houttuyniae 8 parts, Semen Lepidii (Semen Descurainiae) 12 parts, 5 parts, Natrii Sulfas, Herba Lysimachiae 15 parts, Fructus Arctii 25 parts, Radix Puerariae 9 parts, Radix Scrophulariae 12 parts, Indigo Naturalis 9 parts, Radix Cudraniae 25 parts, Calculus Equi 5 parts, Concha Ostreae 15 parts, Pelvetia siliquosa Tseng et C. F. Chang 6 parts, Folium Sauropi 16 parts, Radix phlomidis younghusbandii 18 parts, Umbillcaria esculenta 15 parts, swamp cudweed 17 parts, Folium rumicis acetosae 25 parts, Radix duchesneae indicae 18 parts, Radix Glycyrrhizae uralensis 26 parts, Eugenia javanica Lam 15 parts, Herba lychnidis coronatae 26 parts, Folium Mahoniae 15 parts, Herba Epilobii Angustifoii 17 parts, tongue spray 24 parts.

Its preparation method is:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 80%, reflux 1 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 350 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.1 times, 0.01 times of lactose, the starch of 0.01 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.001 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 3 injection

Radix Asteris 35 parts, 3 parts, Poria, Pericarpium Trichosanthis 16 parts, the Rhizoma Pinelliae 5 parts, Radix Platycodonis 25 parts, 35 parts, Radix Glycyrrhizae, Herba Houttuyniae 8 parts, Semen Lepidii (Semen Descurainiae) 12 parts, 5 parts, Natrii Sulfas, Herba Lysimachiae 15 parts, Fructus Arctii 25 parts, Radix Puerariae 9 parts, Radix Scrophulariae 12 parts, Indigo Naturalis 9 parts, Radix Cudraniae 25 parts, Calculus Equi 5 parts, Concha Ostreae 15 parts, Pelvetia siliquosa Tseng et C. F. Chang 6 parts, Folium Sauropi 16 parts, Radix phlomidis younghusbandii 18 parts, Umbillcaria esculenta 15 parts, swamp cudweed 17 parts, Folium rumicis acetosae 25 parts, Radix duchesneae indicae 18 parts, Radix Glycyrrhizae uralensis 26 parts, Eugenia javanica Lam 15 parts, Herba lychnidis coronatae 26 parts, Folium Mahoniae 15 parts, Herba Epilobii Angustifoii 17 parts, tongue spray 24 parts.

Its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 1 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 96%;

Second step, adding relative to the determining alcohol of the quality 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 hours under the condition of 5 DEG C, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 45 minutes at this, the micron particles of acquisition 1 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%,

3rd step, gets the mixed powder 10g that second step obtains, adds propylene glycol 20g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g needle-use activated carbon, fully stirs 30 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Toxicity test

1. acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The capsule prepared by embodiments of the invention 1 is filled with and is fed, and filling with and feeding volume is 30g/kg, and matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mice maximum dosage-feeding every day is 60g crude drug/kg/ day.Chinese medicine clinical application amount of the present invention be 5g crude drug/day/people, adult body weight in 60KG, average dosage is 0.083g crude drug/kg/ day.By weighing machine: the dosis tolerata of the oral medicine of the present invention of mice (average weight is in 20g) is 723 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

2. cumulative toxicity test: select 20 healthy mices, female, each 10 of hero, with the tablet of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Illustrate that medicine of the present invention does not have cumulative toxicity.

Clinical trial

Treatment target: streptococcus pneumoniae property patients with pneumonia 200 example selecting year January in January, 2013 to 2014 of three first class chest hospitals, man 115 example, female 85 example.Age average out to 35 ± 7 years old.Patient characteristic is: cough, and expectoration usually can be thick or cough rusty expectoration with Huang, and breathe tachypnea, hyperpyrexia, chest and diaphragm feeling of fullness, the pain of pressing, thirsty agitation, yellowish or reddish urine, is hard and dry, red tongue with yellow fur, full and rapid pulse or sliding number.X-ray breast examination disease is rarely seen enhanced lung markings just, and the consolidation phase, most from right middle lobe or side inferior lobe, be mostly limited to a leaf, minority can be limited to list-lung section, the bulging of accidental interlobar fissure then in the large stretch of dense shade of typical case.Be diagnosed as streptococcus pneumoniae property pneumonia phlegm-heat obstructing in the lung to levy.At random patient is divided into embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group, often organizes 50 people.At the age, sex etc. do not have impact to test.

Diagnostic criteria

1.X line breast examination disease is rarely seen enhanced lung markings just, and the consolidation phase, most from right middle lobe or side inferior lobe, be mostly limited to a leaf, minority can be limited to list-lung section, the bulging of accidental interlobar fissure then in the large stretch of dense shade of typical case.

2. etiological examination: (1) bacteriology checking: expectorant, throat swab smear and cultivation, look into and see streptococcus pneumoniae, by bile hemolytic test, serological reaction, glucose fermentation reacts, the peaceful sensitization test of Optochin and α Streptococcus hemolyticus are differentiated, as few in amount of expectoration or be mixed with miscellaneous bacteria and separation difficulty, sample can be injected intraperitoneal mouse, core when dying blood and abdominal cavity leachate are cultivated, pure culture can be obtained, can do capsular swelling test if desired, precipitation, the methods such as coagulation are to identify bacterial type.(2) serodiagnosis: get expectorant, blood and body fluid, with counter immunoelectrophoresis detection specificity polysaccharide antigen, contribute to diagnosis; Even if accept antibacterial therapy, also can measure.

3. phlegm-heat obstructing in the lung is levied: cough, and expectoration usually can be thick or cough rusty expectoration with Huang, and breathe tachypnea, hyperpyrexia, chest and diaphragm feeling of fullness, the pain of pressing, thirsty agitation, yellowish or reddish urine, is hard and dry, red tongue with yellow fur, full and rapid pulse or sliding number.

Therapeutic Method

Treat one group: this is organized 50 people and uses the capsule of embodiments of the invention 1 to treat.Every day 2 times, each 17 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.

Treat two groups: this is organized 50 people and uses the tablet of embodiments of the invention 2 to treat.Every day 2 times, each 17 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.

Treat three groups: this is organized 50 people and uses the injection of embodiments of the invention 3 to treat.Every day 1 time, each 50ml intravenous injection 7 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.

Matched group: this is organized 50 people and uses levofloxacin to treat.Giving the intravenous drip of 2 times 0.2g every day, 7 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.

Criterion of therapeutical effect

Recovery from illness: clinical complete transference cure, x-ray chest films showed lung section or lobe of the lung acute inflammatory disorders disappear, and Sputum bacterial culture display is negative; Effective: clinical symptoms disappears substantially, x-ray chest films showed lung section or lobe of the lung acute inflammatory disorders disappear, and Sputum bacterial culture display is negative; Invalid: clinical symptoms does not disappear, x-ray chest films showed lung section or lobe of the lung acute inflammatory disorders, Sputum bacterial culture display is positive.Total effective rate=recovery from illness+effective.

Therapeutic outcome

Table 1 is the treatment situation contrast of each group

As can be seen from Table 1, the treatment situation of three treatment groups will be better than matched group far away, it can thus be appreciated that medicine of the present invention, treatment streptococcus pneumoniae property pneumonia phlegm-heat obstructing in the lung is levied, and therapeutic effect is good, determined curative effect.

Table 2 is the recurrence contrast after the recovery from illness of each group

Group	Recovery from illness number	Recurrence
			Embodiment 1 group	44	0（0%）
Embodiment 2 groups	45	0（0%）
			Embodiment 3 groups	45	0（0%）
Matched group	25	10（40%）

As can be seen from Table 2, the recovery from illness number of three treatment groups, in follow-up observation, recurrence does not have, and some appearance recurrence of matched group.It can thus be appreciated that medicine of the present invention is levied at treatment streptococcus pneumoniae property pneumonia phlegm-heat obstructing in the lung, and therapeutic effect is good, not easily recurs.

In sum, the present invention levies at treatment streptococcus pneumoniae property pneumonia phlegm-heat obstructing in the lung, and therapeutic effect is good, and determined curative effect is safe and effective, without recurrence, and has no side effect.

Model case: Shanxi institute of traditional Chinese medicine patient, Wang, 40 years old, after relating to rain, high heat, shiver with cold, muscular soreness of whole body, occasionally has nauseating, medical, health check-up: body temperature 39.3 DEG C, thorax respiratory movement amplitude reduces, and percussion is slightly turbid, and auscultation has respiratory murmur to reduce and pleuritic rub.During pulmonary consolidation, dull percussion note, tactile fremitus strengthen and audible and bronchial breathing sound.Blood test is shown in leukocytosis and moves to left, neutrophilic granulocyte more than 80%, visible toxic granulation in cell.Sputum direct smear makes Gram’s staining and capsule stain microscopy, finds diplococcus or the streptococcus of typical Gram-positive, band pod membrane, is diagnosed as pneumococcal pneumonia; dialectical through tcm diagnosis: cough, expectoration usually can be thick or cough rusty expectoration with Huang, breathes tachypnea; hyperpyrexia; chest and diaphragm feeling of fullness, the pain of pressing, thirsty agitation; yellowish or reddish urine; be hard and dry, red tongue with yellow fur, full and rapid pulse or sliding number.It can thus be appreciated that be pneumococcal pneumonia syndrome of phlegm-heat obstructing lung, the injection of embodiment 3 is adopted to treat.Every day 1 time, each 50ml intravenous injection 7 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.Recovery from illness.Later stage follows up half a year, does not recur.Period does not have untoward reaction to occur.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (8)

1. treat the medicine of streptococcus pneumoniae property pneumonia syndrome of phlegm-heat obstructing lung for one kind, it is characterized in that, described medicine is obtained by following raw medicinal material: Radix Asteris, Poria, Pericarpium Trichosanthis, the Rhizoma Pinelliae, Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Semen Lepidii (Semen Descurainiae), Natrii Sulfas, Herba Lysimachiae, Fructus Arctii, Radix Puerariae, Radix Scrophulariae, Indigo Naturalis, Radix Cudraniae, Calculus Equi, Concha Ostreae, Pelvetia siliquosa Tseng et C. F. Chang, Folium Sauropi, Radix phlomidis younghusbandii, Umbillcaria esculenta, swamp cudweed, Folium rumicis acetosae, Radix duchesneae indicae, Radix Glycyrrhizae uralensis.

2. medicine according to claim 1, it is characterized in that, described medicine is obtained by the raw medicinal material of following parts by weight: Radix Asteris 30-40 weight portion, Poria 2-5 weight portion, Pericarpium Trichosanthis 15-20 weight portion, Rhizoma Pinelliae 4-7 weight portion, Radix Platycodonis 20-30 weight portion, Radix Glycyrrhizae 30-40 weight portion, Herba Houttuyniae 6-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-15 weight portion, Natrii Sulfas 4-6 weight portion, Herba Lysimachiae 10-20 weight portion, Fructus Arctii 20-30 weight portion, Radix Puerariae 8-13 weight portion, Radix Scrophulariae 10-14 weight portion, Indigo Naturalis 8-13 weight portion, Radix Cudraniae 20-30 weight portion, Calculus Equi 3-7 weight portion, Concha Ostreae 10-20 weight portion, Pelvetia siliquosa Tseng et C. F. Chang 4-7 weight portion, Folium Sauropi 15-20 weight portion, Radix phlomidis younghusbandii 12-24 weight portion, Umbillcaria esculenta 10-20 weight portion, swamp cudweed 15-20 weight portion, Folium rumicis acetosae 20-30 weight portion, Radix duchesneae indicae 13-24 weight portion, Radix Glycyrrhizae uralensis 20-30 weight portion.

3. medicine according to claim 1, is characterized in that, also comprises Eugenia javanica Lam, Herba lychnidis coronatae, Folium Mahoniae, Herba Epilobii Angustifoii, tongue spray, described medicine is obtained by the raw medicinal material of following parts by weight: Radix Asteris 30-40 weight portion, Poria 2-5 weight portion, Pericarpium Trichosanthis 15-20 weight portion, Rhizoma Pinelliae 4-7 weight portion, Radix Platycodonis 20-30 weight portion, Radix Glycyrrhizae 30-40 weight portion, Herba Houttuyniae 6-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-15 weight portion, Natrii Sulfas 4-6 weight portion, Herba Lysimachiae 10-20 weight portion, Fructus Arctii 20-30 weight portion, Radix Puerariae 8-13 weight portion, Radix Scrophulariae 10-14 weight portion, Indigo Naturalis 8-13 weight portion, Radix Cudraniae 20-30 weight portion, Calculus Equi 3-7 weight portion, Concha Ostreae 10-20 weight portion, Pelvetia siliquosa Tseng et C. F. Chang 4-7 weight portion, Folium Sauropi 15-20 weight portion, Radix phlomidis younghusbandii 12-24 weight portion, Umbillcaria esculenta 10-20 weight portion, swamp cudweed 15-20 weight portion, Folium rumicis acetosae 20-30 weight portion, Radix duchesneae indicae 13-24 weight portion, Radix Glycyrrhizae uralensis 20-30 weight portion, Eugenia javanica Lam 10-20 weight portion, Herba lychnidis coronatae 25-30 weight portion, Folium Mahoniae 10-20 weight portion, Herba Epilobii Angustifoii 12-24 weight portion, tongue spray 20-30 weight portion.

4. medicine according to claim 1 and 2, it is characterized in that, described medicine is obtained by the raw medicinal material of following parts by weight: Radix Asteris 35 weight portion, Poria 3 weight portion, Pericarpium Trichosanthis 16 weight portion, the Rhizoma Pinelliae 5 weight portion, Radix Platycodonis 25 weight portion, Radix Glycyrrhizae 35 weight portion, Herba Houttuyniae 8 weight portion, Semen Lepidii (Semen Descurainiae) 12 weight portion, Natrii Sulfas 5 weight portion, Herba Lysimachiae 15 weight portion, Fructus Arctii 25 weight portion, Radix Puerariae 9 weight portion, Radix Scrophulariae 12 weight portion, Indigo Naturalis 9 weight portion, Radix Cudraniae 25 weight portion, Calculus Equi 5 weight portion, Concha Ostreae 15 weight portion, Pelvetia siliquosa Tseng et C. F. Chang 6 weight portion, Folium Sauropi 16 weight portion, Radix phlomidis younghusbandii 18 weight portion, Umbillcaria esculenta 15 weight portion, swamp cudweed 17 weight portion, Folium rumicis acetosae 25 weight portion, Radix duchesneae indicae 18 weight portion, Radix Glycyrrhizae uralensis 26 weight portion.

5. the medicine according to claim 1 or 3, it is characterized in that, described medicine is obtained by the raw medicinal material of following parts by weight: Radix Asteris 35 weight portion, Poria 3 weight portion, Pericarpium Trichosanthis 16 weight portion, the Rhizoma Pinelliae 5 weight portion, Radix Platycodonis 25 weight portion, Radix Glycyrrhizae 35 weight portion, Herba Houttuyniae 8 weight portion, Semen Lepidii (Semen Descurainiae) 12 weight portion, Natrii Sulfas 5 weight portion, Herba Lysimachiae 15 weight portion, Fructus Arctii 25 weight portion, Radix Puerariae 9 weight portion, Radix Scrophulariae 12 weight portion, Indigo Naturalis 9 weight portion, Radix Cudraniae 25 weight portion, Calculus Equi 5 weight portion, Concha Ostreae 15 weight portion, Pelvetia siliquosa Tseng et C. F. Chang 6 weight portion, Folium Sauropi 16 weight portion, Radix phlomidis younghusbandii 18 weight portion, Umbillcaria esculenta 15 weight portion, swamp cudweed 17 weight portion, Folium rumicis acetosae 25 weight portion, Radix duchesneae indicae 18 weight portion, Radix Glycyrrhizae uralensis 26 weight portion, Eugenia javanica Lam 15 weight portion, Herba lychnidis coronatae 26 weight portion, Folium Mahoniae 15 weight portion, Herba Epilobii Angustifoii 17 weight portion, tongue spray 24 weight portion.

6. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 350 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.05 ~ 0.3:0.05 ~ 0.2, incapsulate in housing, obtain capsule by described capsule 's content.

7. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 350 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.01 ~ 0.12 times of lactose, the starch of 0.01 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.001 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

8. a preparation method for the medicine described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 96%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 45 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 20g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.