CN104740085A - Method for producing blood glucose-reducing soft capsules by use of large dosage of dried rehamnnia root - Google Patents
Method for producing blood glucose-reducing soft capsules by use of large dosage of dried rehamnnia root Download PDFInfo
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- CN104740085A CN104740085A CN201510183473.4A CN201510183473A CN104740085A CN 104740085 A CN104740085 A CN 104740085A CN 201510183473 A CN201510183473 A CN 201510183473A CN 104740085 A CN104740085 A CN 104740085A
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Abstract
The invention provides a method for producing blood glucose-reducing soft capsules by use of a large dosage of dried rehamnnia root. The preparation method comprises the following steps: performing supercritical extraction on dried rehamnnia root, prepared rehmannia root, Chinese wolfberry and milkvetch root to obtain extracts for later use, respectively; pulping fresh rehamnnia root, filtering to obtain a fresh rehamnnia root pulp, extracting the filter residue by use of ethanol to obtain an extract and adding the extract back to the fresh rehamnnia root pulp and mixing evenly for later use; performing supercritical extraction on hawthorn leaves to obtain a hawthorn flavone extract, and decoloring the hawthorn flavone extract for later use; comprehensively mixing the dried rehamnnia root extract, the prepared rehmannia root, the fresh rehmannia root pulp mixed solution, the Chinese wolfberry extract and the milkvetch root extract, the hawthorn flavone and a ramie mixed oil to obtain an oily content, and pressing the oily content with a capsule material into standard soft capsules by use of a mold of an apparatus according to dosages.
Description
Technical field
What the present invention relates to is the method that the heavy dose of Radix Rehmanniae of a kind of use makes blood sugar lowering soft capsule.
Background technology
With the Chinese medicine of Radix Rehmanniae Preparata and Radix Rehmanniae compatibility, application is very extensive, and major part is all relevant with the kidney invigorating, as various Dihuang Wan.And be that principal agent works in coordination with Radix Rehmanniae Preparata with heavy dose of Radix Rehmanniae and Radix Rehmanniae, the full nutrition mixed extracts such as the oligosaccharide obtain three Radix Rehmanniae respectively and catalpol, make the soft capsule that diabetes patient is suitable for, still do not have bibliographical information at present.Have data to show, with the prescription such as Radix Rehmanniae Preparata and Radix Rehmanniae compatibility in treatment diabetes, effect is pretty good, even has than all obvious with blood sugar lowering western medicine result.After deliberation, find that Radix Rehmanniae contains a large amount of alpha-glucosidase inhibitor compositions, as three glucosides-Martynoside. D and catalpol etc., it can suppress the rapid rising of post-prandial glycemia, and blood glucose can be made slowly steady.Through the investigation and comparison to Radix Rehmanniae Preparata and Radix Rehmanniae and Radix Rehmanniae, find that in Radix Rehmanniae, content of stachyose is higher than life (doing) Radix Rehmanniae, and hexose, sucrose and trisaccharide content are lower than Radix Rehmanniae, only containing a small amount of reducing sugar in Radix Rehmanniae, and containing a large amount of reducing sugar in Radix Rehmanniae Preparata, and its glycoside structure and content have significant change.Have 20 seed amino acids in Radix Rehmanniae, wherein arginine content is the highest, and also containing 20 multiple element and mannitol, catalpol, the rehmanin etc. such as ferrum, zinc, manganese, chromium, chromium is very great to diabetes meaning.Only have 15 seed amino acids in Radix Rehmanniae, in Radix Rehmanniae Preparata, amino acid content is very low, amino acid whose how many and just also very great to the rehabilitation meaning of diabetes.The main component of blood sugar lowering all more to be existed in Radix Rehmanniae and Radix Rehmanniae, the main component of three glucosides-Martynoside. D(blood sugar lowering) be present in Radix Rehmanniae more, and be not easy to decompose; And the catalpol (being also one of main sugar-lowering components) existed in Radix Rehmanniae, but easily decompose. moreSo selecting on Radix Rehmanniae, must innovate, combine with three kinds of Radix Rehmanniae, namely Radix Rehmanniae, Radix Rehmanniae, Radix Rehmanniae Preparata combine, and also will adopt different process method and usage ratio, make it reach best object.Have report display, the hypoglycemic effect of Rehmanniae Bolus of Eight Ingredients is not so good as the good of single.After deliberation, reach a conclusion, the object of these compound rehmannia balls is not only in order to blood sugar lowering, so after compatibility, the main sugar-lowering components of its biological structure on Radix Rehmanniae has impact.So at compatibility, the composition newly increased must be improved hypoglycemic effect.As compositions such as the oligosaccharide in Radix Rehmanniae, the expression of fatty tissue gene can be suppressed, improve islet beta cell function, improve disorders of lipid metabolism, thus reduce the blood glucose of test rat.And Fructus Lycii also has identical effect, so add Fructus Lycii would not affect hypoglycemic effect, improve blood sugar lowering on the contrary and repair islet beta cell function.Radix Rehmanniae Preparata is better than tonifying kidney-yin, and it is serious that diabetes mostly are injury of kidney, and some diabetics urine protein are very high, kidney can not get repairing, and is also the thing of killing very much, so while use Radix Rehmanniae Preparata, separately add Radix Astragali QI invigorating, eliminate urine protein, the integral rehabilitation of diabetes can be improved on the contrary.Also containing alpha-glucosidase inhibitor composition in the Radix Astragali, as astragalus polysaccharides, and the color and luster of its extract is faint yellow, is applicable to doing soft gelatin capsule, does not affect sense organ.Process tests on white mice, gavage heavy dose of Radix Rehmanniae, Radix Rehmanniae, Radix Rehmanniae Preparata and Fructus Lycii, Radix Astragali mixed extract to its fro diabetic white mouse, it shows the promising result of post-prandial glycemia.This points out us to adopt three kinds of Radix Rehmanniae different process, different ratio, and it is necessary for carrying out full nutrition extraction.Particularly adopt soft capsule, flavones content and its unsaturated fatty acid of strengthening carrier oil are worked in coordination with, to diabetes complicated angiopathy and Fundus oculi lesion, purification blood vessel, repair blood vessel all beneficial, this and other dosage form has the application form of very large difference and advantage, the health product that the diabetes patient made uses, and has certain innovative significance.
Summary of the invention
The object of this invention is to provide the method that the heavy dose of Radix Rehmanniae of a kind of use makes blood sugar lowering soft capsule.
The object of the present invention is achieved like this: a, get Radix Rehmanniae, with supercritical extraction process, obtains containing three glucosides-Martynoside. D and catalpol full nutrition extract, for subsequent use; B, get Radix Rehmanniae Preparata, with supercritical extraction process, obtain Radix Rehmanniae full nutrition extract, for subsequent use; C, get Radix Rehmanniae, clean, stripping and slicing, making beating, filter, obtain Radix Rehmanniae slurry, filtering residue ethanol extraction method is extracted concentrated solution, then return to add in Radix Rehmanniae serosity and mix, for subsequent use; D, get Fructus Lycii, with supercritical extraction process, obtain the faint yellow extract of lycium barbarum polysaccharide full nutrition, for subsequent use; E, get the Radix Astragali, with supercritical extraction process, obtain the micro-yellow extract of astragalus polysaccharides full nutrition, for subsequent use; F, get Folium Crataegi, with supercritical extraction process, obtain hawthorn flavone extract, after decolouring, for subsequent use; Radix Rehmanniae slurry mixed liquor 5-20%, the wolfberry fruit extract 5-20% of Step d acquisition that the Radix Rehmanniae Preparata extract 5-20% that g, the Radix Rehmanniae extract 40-80% getting the acquisition of a step, b step obtain, step c obtain, the Radix Astragali extract 5-20% of step e acquisition mix, obtain synthetic mixture, for subsequent use; H, get commercial hemp oil 80%, f step obtain Fructus Crataegi flavone 20%, mix, obtain miscella, for subsequent use; The miscella 20-40% that i, the synthetic mixture 60-80% getting the acquisition of g step, h step obtain, after mixing, obtains oily body content, for subsequent use; J, the soft gelatin capsule capsule material rubber made of edible Gelatinum oxhide, spread in equipment, is according to dosage automatically injected the oily body content that i step obtains, is pressed into the granule soft capsule meeting measurement criteria by mould; Every 1g, each 1-2 ball, every day three times.
Good effect of the present invention is: because Radix Rehmanniae Preparata is different with the performance of Radix Rehmanniae in blood sugar lowering etc., so, apply also different, Radix Rehmanniae is also brought in prescription technique simultaneously, and traditional Radix Rehmanniae does health beverage use, few people share three.So respectively possess some good points and weakness, be fully used and complementation, effectively can improve bioavailability.Selected interpolation uses Fructus Lycii, and not only its blood sugar lowering principle is similar with Radix Rehmanniae, and its bata-carotene has cell regeneration and reparation meaning to beta Cell of islet bioactive peptide; Add and use the Radix Astragali, not still in the Radix Astragali also containing alpha-glucosidase inhibitor composition, simultaneously, the Radix Astragali is to the urine protein of diabetes complicated nephropathy, have and well to eliminate and to kidney repair, add that a soft gelatin capsule carrier hemp oil Fructus Crataegi flavone is optimized, it also has positive effect to diabetes complicated angiopathy.Concrete raw-material function is as follows:
Radix Rehmanniae, Radix Rehmanniae: sweet, bitter, cold, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, enters nutrient blood for epidemic febrile disease, and fever of the body xerostomia, tongue fall or the card such as red, also for heat at blood system, the card such as haematemesis, hematuria of the absurd row of forcing blood, to consumption of YIN caused by febrile disease, thirsty polydipsia is effective in cure.Single Radix Rehmanniae hypoglycemic activity is more remarkable than Radix Puerariae; Radix Rehmanniae can be used for calentura tongue and falls excessive thirst, yin asthenia generating intrinsic heat diabetics.Have scholar to find in the research of the diabetes combined therapy of Chinese and Western medicine, for a long time with insulin or oral antidiabetic drug treatment, symptom is improved and all not good enough person of blood glucose decline, and add with the Radix Rehmanniae, Radix Rehmanniae Preparata for after main component mixture, blood glucose generally declines; Evidence suggests that raw, ripe two ground play a significant role in hypoglycemic mixture, particularly Radix Rehmanniae plays an important role; Radix Rehmanniae aminoacid reaches kind more than 20, and Radix Rehmanniae only has 15 kinds, and Papillary has complementarity.
Radix Rehmanniae Preparata: enrich blood, nourishing kidney nourishing YIN, uses treating the liver deficiency of the kidney yin, hectic fever, night sweat, seminal emission, soreness of the waist and knees and the disease such as to quench one's thirst.Animal experiment, has heart tonifying, diuresis, blood sugar lowering, the effects such as blood pressure lowering.Its blood sugar reducing component and amino acid content are all lower than Radix Rehmanniae and Radix Rehmanniae, and three share, and effect is better, and bioavailability improves greatly.
Fructus Lycii: sweet in the mouth, property is put down.Return liver, kidney channel.Effect: the function having nourishing the liver and kidney, replenishing vital essence to improve eyesight.For diseases such as asthenia damage of essence, Light-headedness, tinnitus, ache of the spinal column, seminal emissions.Pharmacological action: (1) enhancing non-specific immunity function: mouse gavaging lycium barbarum water extract or alcohol extract intramuscular injection, all significantly can strengthen the phagocytic activity of reticuloendothelial system to india ink.(2), hemoposieis: every day gavages Lycium Barbarum, has facilitation to the hemopoietic function of normal mouse.(3), hypoglycemic activity: the reduction that lycium barbarum extracts can cause rat blood sugar remarkable and lasting.The blood sugar reducing function of its polysaccharide and the very similar of Radix Rehmanniae.The expression of fatty tissue gene can be suppressed, improve islet beta cell function, improve disorders of lipid metabolism, thus reduce the blood glucose of test rat.
The Radix Astragali: invigorating QI to consolidate the body surface resistance, diuresis poison holding, weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea metrorrhagia, spontaneous perspiration, edema, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.This product can strengthen metabolism, improves nutrition of whole body state.Containing alpha-glucosidase inhibitor composition, its astragalus polysaccharides has more lasting obvious effect to blood sugar lowering.
Fructus Crataegi flavone: the Fructus Crataegi flavone extracted from Folium Crataegi, can make coronary artery expansion, has blood fat reducing, blood pressure lowering and cardiotonic, can improve the effect of heart vigor and stimulating central nervous system system, and tool antioxidation.Protective effect is had to the cardiac function for the treatment of myocardial ischemia damage.
Boehmeria: containing unsaturated fatty acid more than 90%, polyunsaturated fatty acid more than 79%, linoleic acid content is particularly abundant, reaches 77.4%-78.84%, also containing 17 seed amino acids.Unsaturated fatty acid is to adjusting blood lipid, and tumor prevention, Improving memory many-side plays an important role, and polyunsaturated fatty acid can reduce the M & M of cardiovascular and cerebrovascular disease, has preventive effect to diabetes complicated angiopathy.
Detailed description of the invention
Embodiment one: a, get Radix Rehmanniae, with supercritical extraction process, obtain containing three glucosides-Martynoside. D and catalpol full nutrition extract, for subsequent use; B, get Radix Rehmanniae Preparata, with supercritical extraction process, obtain Radix Rehmanniae full nutrition extract, for subsequent use; C, get Radix Rehmanniae, clean, stripping and slicing, making beating, filter, obtain Radix Rehmanniae slurry, filtering residue ethanol extraction method is extracted concentrated solution, then return to add in Radix Rehmanniae serosity and mix, for subsequent use; D, get Fructus Lycii, with supercritical extraction process, obtain the faint yellow extract of lycium barbarum polysaccharide full nutrition, for subsequent use; E, get the Radix Astragali, with supercritical extraction process, obtain the micro-yellow extract of astragalus polysaccharides full nutrition, for subsequent use; F, get Folium Crataegi, with supercritical extraction process, obtain hawthorn flavone extract, after decolouring, for subsequent use; The Radix Rehmanniae slurry mixed liquor 20% that the Radix Rehmanniae Preparata extract 10% that g, the Radix Rehmanniae extract 40% getting the acquisition of a step, b step obtain, step c obtain, the wolfberry fruit extract 20% of Step d acquisition, the Radix Astragali extract 10% of step e acquisition mix, obtain synthetic mixture, for subsequent use; H, get commercial hemp oil 80%, f step obtain Fructus Crataegi flavone 20%, mix, obtain miscella, for subsequent use; The miscella 40% that i, the synthetic mixture 60% of getting the acquisition of g step, h step obtain, after mixing, obtains oily body content, for subsequent use; J, the soft gelatin capsule capsule material rubber made of edible Gelatinum oxhide, spread in equipment, is according to dosage automatically injected the oily body content that i step obtains, is pressed into the granule soft capsule meeting measurement criteria by mould; Every 1g, each 1-2 ball, every day three times.
Embodiment two: a, get Radix Rehmanniae, with supercritical extraction process, obtain containing three glucosides-Martynoside. D and catalpol full nutrition extract, for subsequent use; B, get Radix Rehmanniae Preparata, with supercritical extraction process, obtain Radix Rehmanniae full nutrition extract, for subsequent use; C, get Radix Rehmanniae, clean, stripping and slicing, making beating, filter, obtain Radix Rehmanniae slurry, filtering residue ethanol extraction method is extracted concentrated solution, then return to add in Radix Rehmanniae serosity and mix, for subsequent use; D, get Fructus Lycii, with supercritical extraction process, obtain the faint yellow extract of lycium barbarum polysaccharide full nutrition, for subsequent use; E, get the Radix Astragali, with supercritical extraction process, obtain the micro-yellow extract of astragalus polysaccharides full nutrition, for subsequent use; F, get Folium Crataegi, with supercritical extraction process, obtain hawthorn flavone extract, after decolouring, for subsequent use; The Radix Rehmanniae slurry mixed liquor 20% that the Radix Rehmanniae Preparata extract 20% that g, the Radix Rehmanniae extract 30% getting the acquisition of a step, b step obtain, step c obtain, the wolfberry fruit extract 10% of Step d acquisition, the Radix Astragali extract 20% of step e acquisition mix, obtain synthetic mixture, for subsequent use; H, get commercial hemp oil 80%, f step obtain Fructus Crataegi flavone 20%, mix, obtain miscella, for subsequent use; The miscella 30% that i, the synthetic mixture 70% of getting the acquisition of g step, h step obtain, after mixing, obtains oily body content, for subsequent use; J, the soft gelatin capsule capsule material rubber made of edible Gelatinum oxhide, spread in equipment, is according to dosage automatically injected the oily body content that i step obtains, is pressed into the granule soft capsule meeting measurement criteria by mould; Every 1g, each 1-2 ball, every day three times.
Embodiment three: a, get Radix Rehmanniae, with supercritical extraction process, obtain containing three glucosides-Martynoside. D and catalpol full nutrition extract, for subsequent use; B, get Radix Rehmanniae Preparata, with supercritical extraction process, obtain Radix Rehmanniae full nutrition extract, for subsequent use; C, get Radix Rehmanniae, clean, stripping and slicing, making beating, filter, obtain Radix Rehmanniae slurry, filtering residue ethanol extraction method is extracted concentrated solution, then return to add in Radix Rehmanniae serosity and mix, for subsequent use; D, get Fructus Lycii, with supercritical extraction process, obtain the faint yellow extract of lycium barbarum polysaccharide full nutrition, for subsequent use; E, get the Radix Astragali, with supercritical extraction process, obtain the micro-yellow extract of astragalus polysaccharides full nutrition, for subsequent use; F, get Folium Crataegi, with supercritical extraction process, obtain hawthorn flavone extract, after decolouring, for subsequent use; The Radix Rehmanniae slurry mixed liquor 5% that the Radix Rehmanniae Preparata extract 5% that g, the Radix Rehmanniae extract 80% getting the acquisition of a step, b step obtain, step c obtain, the wolfberry fruit extract 5% of Step d acquisition, the Radix Astragali extract 5% of step e acquisition mix, obtain synthetic mixture, for subsequent use; H, get commercial hemp oil 80%, f step obtain Fructus Crataegi flavone 20%, mix, obtain miscella, for subsequent use; The miscella 20% that i, the synthetic mixture 80% of getting the acquisition of g step, h step obtain, after mixing, obtains oily body content, for subsequent use; J, the soft gelatin capsule capsule material rubber made of edible Gelatinum oxhide, spread in equipment, is according to dosage automatically injected the oily body content that i step obtains, is pressed into the granule soft capsule meeting measurement criteria by mould; Every 1g, each 1-2 ball, every day three times.
Claims (1)
1. make a method for blood sugar lowering soft capsule of heavy dose of Radix Rehmanniae, its preparation method is as follows: a, get Radix Rehmanniae, with supercritical extraction process, obtains containing three glucosides-Martynoside. D and catalpol full nutrition extract, for subsequent use; B, get Radix Rehmanniae Preparata, with supercritical extraction process, obtain Radix Rehmanniae full nutrition extract, for subsequent use; C, get Radix Rehmanniae, clean, stripping and slicing, making beating, filter, obtain Radix Rehmanniae slurry, filtering residue ethanol extraction method is extracted concentrated solution, then return to add in Radix Rehmanniae serosity and mix, for subsequent use; D, get Fructus Lycii, with supercritical extraction process, obtain the faint yellow extract of lycium barbarum polysaccharide full nutrition, for subsequent use; E, get the Radix Astragali, with supercritical extraction process, obtain the micro-yellow extract of astragalus polysaccharides full nutrition, for subsequent use; F, get Folium Crataegi, with supercritical extraction process, obtain hawthorn flavone extract, after decolouring, for subsequent use; Radix Rehmanniae slurry mixed liquor 5-20%, the wolfberry fruit extract 5-20% of Step d acquisition that the Radix Rehmanniae Preparata extract 5-20% that g, the Radix Rehmanniae extract 40-80% getting the acquisition of a step, b step obtain, step c obtain, the Radix Astragali extract 5-20% of step e acquisition mix, obtain synthetic mixture, for subsequent use; H, get commercial hemp oil 80%, f step obtain Fructus Crataegi flavone 20%, mix, obtain miscella, for subsequent use; The miscella 20-40% that i, the synthetic mixture 60-80% getting the acquisition of g step, h step obtain, after mixing, obtains oily body content, for subsequent use; J, the soft gelatin capsule capsule material rubber made of edible Gelatinum oxhide, spread in equipment, is according to dosage automatically injected the oily body content that i step obtains, is pressed into the granule soft capsule meeting measurement criteria by mould; Every 1g, each 1-2 ball, every day three times.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305816A (en) * | 2000-01-17 | 2001-08-01 | 王茂田 | Medicine for treating diabetes |
| CN101589833A (en) * | 2008-05-31 | 2009-12-02 | 武汉诚达日化研究所 | The manufacture method of diabetes-alleviating beverage |
| CN104225074A (en) * | 2014-08-29 | 2014-12-24 | 孙广军 | Traditional Chinese medicinal pill for treating diabetes |
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2015
- 2015-04-19 CN CN201510183473.4A patent/CN104740085A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305816A (en) * | 2000-01-17 | 2001-08-01 | 王茂田 | Medicine for treating diabetes |
| CN101589833A (en) * | 2008-05-31 | 2009-12-02 | 武汉诚达日化研究所 | The manufacture method of diabetes-alleviating beverage |
| CN104225074A (en) * | 2014-08-29 | 2014-12-24 | 孙广军 | Traditional Chinese medicinal pill for treating diabetes |
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| 张奕 等: "《糖尿病现代治疗及护理》", 29 February 2008, 海南出版社 * |
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