CN104736687A - Soap composition - Google Patents
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- CN104736687A CN104736687A CN201380057276.7A CN201380057276A CN104736687A CN 104736687 A CN104736687 A CN 104736687A CN 201380057276 A CN201380057276 A CN 201380057276A CN 104736687 A CN104736687 A CN 104736687A
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/02—Compositions of detergents based essentially on soap on alkali or ammonium soaps
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/28—Organic compounds, e.g. vitamins containing halogen
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- Detergent Compositions (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a soap composition, particularly to a personal wash composition with synergistic antibacterial activity. The present inventors have found that synergistic antimicrobial activity is exhibited when a soap composition comprising 12-50% sodium laurate as a percentage of total soap is used along with certain antimicrobial actives.
Description
Invention field
The present invention relates to soap composition, particularly there is the personal wash compositions of Synergistic antimicrobial activity.
Background of invention and prior art
Specification sheets should not be considered as admitting that the prior art is known or forms a part for general knowledge known in this field to any discussion of prior art in the whole text.
Personal wash compositions can obtain in a variety of manners, and as soap bar, transparent soap bar, it comprises and waters casting rod (cast-bar), liquid soap, and it comprises Liquid soap composition, breast frost and gel base product.Commercially available soap composition has one or more " soaps ", and it has the implication that this area is understood usually: the salt of mono carboxylic lipid acid.Counter ion normally sodium, potassium, ammonium or the alkanol ammonium ion of described salt, but also can use other suitable ion known in the art.Based on the composition of soap class, i.e. soap bar, usually an alkali metal salt of the lipid acid of 15 to 80 % by weight is contained, depend on that this soap composition is solid or liquid form, it forms total fatty material (TFM), and remainder is that water (about 10-20%) and other composition are as metal ion chelation agent, colorant, essence, sanitas etc.Structural agent and filler also usually to add in such composition to replace a part of soap on a small quantity, keep the required character of product simultaneously.TFM content be about 70% soap bar be called " perfumed soap (toilet soap) ", and TFM be about 40% those be called " bath soap (bathing bar) ".
There is the microorganism of several types in an atmosphere, as bacterium, virus and mould, some of them like existence and breeding on human body skin.The part residing in these biologies on human body skin can cause unacceptable symptom, and as body odor, papule (pimple) and acne (acne), this is being cosmetically that people is unacceptable.These symptoms are aggravated with moist weather condition further because of hot.A kind of method eliminating these microorganisms resided on skin preferably uses cleaning composition such as soap they to be washed off.
Soap itself is known has anti-microbial properties.In addition, the germicidal soap composition of formulated is also known in this area, and it is used for the treatment of serious dermatosis as scabies.In order to provide antimicrobial benefits via soap composition, sterilant or antiseptic-germicide are as triclosan (i.e. Triclosan; TCN) and triclocarban (TCC) be known and use.It is also desirable that carry out providing anti-microbial effect in the short time range of cleaning at most people, described short-term time scale, for being less than one minute, is less than half a minute sometimes.The antimicrobial composition (having prepared soap class on this basis) comprising the combination of active ingredients of essential oils is also known, and a kind of such composition is disclosed in WO 2010046238.
In lipid acid, usually derived from the lauric acid of Oleum Cocois for soapmaking.Oleum Cocois uses with about 20% of whole oil/fatty acid mixt usually, and such coconut oil mass makes this soap composition have the lauric acid of about 10%.In WO 07065538, report the composition comprising high lauric acid soap content.
The present inventor finds surprisingly, comprises the lauric acid soap of specified quantitative and the soap composition of specific antimicrobial acivity composition and provides excellent antimicrobial acivity because of the cooperative interaction of described soap and activeconstituents.
Therefore, an object of the present invention is with the remarkable anti-microbial properties providing the enhancing from soap lower than antimicrobial acivity constituent concentration known before this.
Another object of the present invention is the anti-microbial properties providing enhancing in relatively short time range.
Another object of the present invention is to provide to comprise and is easy to obtain and is easy to the composition that is mixed in said composition, keeps the personal wash compositions of low cost thus.
Summary of the invention
A first aspect of the present invention relates to a kind of soap composition, and it comprises:
A) soap of 15 to 80 % by weight;
B) one or more antimicrobial acivity compositions of 0.01 to 5 % by weight, described antimicrobial acivity composition is selected from active ingredients of essential oils and parachlormetaxylenol;
12 to 50 % by weight of wherein said soap is lauric salt;
Wherein this active ingredients of essential oils is selected from phantol, vernol, Geraniol, terpinol, thymol, oxymethoxyallylbenzene and composition thereof.
This lauric salt is preferably sodium laurate or potassium laurate.
According to a second aspect of the invention, provide the method for disinfecting surface, it comprises the following steps:
A. composition of the present invention is applied to this on the surface; With
B. said composition is removed on the surface from this.
In the third aspect, the invention provides composition of the present invention for improving the purposes of health.
Detailed Description Of The Invention
By reading as detailed below and claims, these and other aspect, feature & benefits will become apparent those of ordinary skill in the art.For avoiding query, any feature any other side used in the present invention of one aspect of the invention.Word " comprises " and is intended to refer to " comprising " but not necessarily " by ... composition " or " composition ".In other words, listed step or selection need not to be exhaustive.It should be noted that the example provided in specification sheets is below intended to illustrate the present invention, and be not intended to limit the invention to those examples itself.Similarly, all per-cent is weight/weight percent, unless otherwise specified.
Except in operation and comparative example, or when clearly stating separately, in this specification sheets, represent that quantity of material or reaction conditions, the physical properties of material and/or all numerals of purposes are interpreted as being modified by word " approximately ".Unless otherwise specified, the digital scope in form " x to y " is interpreted as and comprises x and y.When describing multiple preferable range for specific features with form " x to y ", be interpreted as all scopes also contemplating the different end points of combination.
Antimicrobial composition used herein refers to and comprises for cleaning and disinfection regional area, the such as skin of Mammals (particularly the mankind) and/or the composition of hair.Such composition, comprises soap according to the present invention, and therefore normally a kind of cleaning-type cleaning compositions, it can additionally for improving outward appearance, controlling or consider for overall aesthetic for smell.Composition of the present invention can be liquid form, but can carry out changing comprises lotion, breast frost, foam or gel, or astringent, or use instrument or apply via facial mask, liner or patch.Said composition is preferably solid form." skin " used herein refer to comprise on the face with the skin (such as neck, chest, back, arm, oxter, hand, leg, buttocks and scalp) on health.When to provide sterilization and clean specific purpose to prepare this product, composition of the present invention is also relevant to the application on human body other cutin substrate any such as hair in addition to the skin.
Composition of the present invention can with any one preparation of the product form hereinafter enumerated, and it is defined as follows separately.Soap bar refers to the composition of shaped solid form, and it comprises soap, i.e. the salt of lipid acid.Soap bar by development and mold pressing (milled and plodded) route or can be prepared by founding route.Liquid personal cleansing composition refers to for various personal cleanliness's application as washed one's hands, taking a shower, wash one's face or cleaning the Liquid form compositions of hair.
Antibacterial soap compositions and personal wash compositions are well known in the art.Such composition can obtain with various product form, as perfumed soap, bath soap, Liquid soap, bathing agents and antibacterial soap lye wet tissue.The health consciousness improved, the country of the Urban and rural area health in addition improved constantly and international standard, cause the heavy demand to this series products.The use of antibacterial soap compositions is not limited only to the people living in Rural areas, has also become a part for the daily hygiene plan of the people living in modern metropolitan cities.
Soap is defined as the salt of lipid acid, and it is by with alkali, as in sodium hydroxide, potassium hydroxide, ammonium hydroxide or triethylamine and corresponding lipid acid prepare.An alkali metal salt of carboxylic acid is by with in alkali and corresponding lipid acid or prepare with the oil (triglyceride level) that alkaline purification contains desired fats acid composition.A kind of rear method is commonly referred to saponification.Alkali used is corresponding metal hydroxides or metal carbonate.Oleum Cocois and palm-kernel oil are rich in lauric acid, therefore also can be used as the precursor of lauroleate used according to the invention.An alkali metal salt of the present invention is preferably selected from sodium salt, sylvite or its mixture.If use sodium salt as described in the present invention, resulting composition can be used for preparing solid soap.On the other hand, sylvite causes more soft product, and when desired product is liquid soap, this is especially preferred.The mixture of sodium salt and sylvite causes the product of the hardness/pliability with intermediate degree, and those skilled in the art can suitably balance this ratio as required.
Soap itself has certain antimicrobial acivity, and this can become assign to strengthen further by using antimicrobial acivity according to the present invention.
Soap in soap composition of the present invention comprises the part be made up of lauroleate soap and the another part be made up of non-lauric hydrochlorate soap usually.When Oleum Cocois or coconut fatty acid are used as the precursor of lauroleate soap, the saponification of distilled fatty acid blend can generate non-lauric hydrochlorate soap component in compound soap.
Distilled fatty acid (DFA) is the mixture of C14 to C18 lipid acid, and it comprises tetradecanoic acid, palmitinic acid, stearic acid, oleic acid, linoleic acid plus linolenic acid.Personal wash compositions usually by operating weight than manufacturing for the Oleum Cocois soap of 80:20 to 20:80 and the combination of DFA soap.This ratio can be changed to realize results needed.
The present inventor has been found that and confirms, in the composition of the lauroleate soap (15 to 50% of soap gross weight) containing specified quantitative and specific antimicrobial acivity composition, there is surprising synergy.Both in conjunction with time show excellent antimicrobial efficacy, this can provide larger benefit to user.
The present invention relates to soap composition, it comprises the soap of 15 to 80 % by weight and one or more antimicrobial acivity compositions of 0.01 to 5%, and described antimicrobial acivity composition is selected from active ingredients of essential oils and parachlormetaxylenol; 12 to 50 % by weight of wherein said soap is lauric salt.
Composition of the present invention comprises the soap of 15 to 80 % by weight.When this soap composition is solid form, it preferably comprises the soap of 40 to 80 % by weight, more preferably 55 to 76 % by weight.When said composition is liquid form, it preferably comprises the soap of 15 to 30%, more preferably the soap of 15 to 20%.According to the present invention, described lauric salt preferably forms 12 to 25 % by weight of the soap total amount existed in said composition.
Lauric acid is a kind of mono carboxylic lipid acid with 12 carbon atoms.Lauric IUPAC title is " dodecanoic acid ".It is found in the degree be in fact present in about 50% in palm-kernel oil and Oleum Cocois.Term " lauric salt " is for describing the lauric acid derivative of use alkali/basic material neutralization.This salt is preferably lithium, sodium, potassium, calcium, magnesium, ammonium, triethyl ammonium or tri ethanol ammonium salt; This salt is more preferably sodium laurate or potassium laurate.The suitable combination of sodium salt and sylvite can also be used and do not depart from the scope of the present invention.
Term total fatty material (being usually abbreviated as TFM) is present in lipid acid in soap class and the triglyceride level residue weight percent relative to whole composition for representing, and does not consider positively charged ion together.
This soap can be obtained by saponified fat/oil and/or lipid acid.Be generally used for the fat of soapmaking or oil can be such as tallow, tallow stearines, plam oil, palm stearin, soybean oil, fish oil, Viscotrol C, Rice pollard oil, Trisun Oil R 80, Oleum Cocois, babassu oil, palm-kernel oil and other.In the above methods, this fatty acid derived is from the oil/fat being selected from coconut, rice bran, peanut, tallow, palm, palm-kernel, cottonseed, soybean, castor-oil plant etc.
This fatty acid soaps can also synthesize preparation (such as by the oxidation of oil or by Fischer-Tropsch method hydrogenation carbon monoxide).Resinous acid can be used, those as being present in Yatall MA.Naphthenic acid is also suitable.
Tallow fatty acids also can comprise the oleic acid of Zoomeric acid, the approximately 36-50% of stearic acid, the approximately 0-4% of palmitinic acid, the approximately 14-31% of tetradecanoic acid, the approximately 21-32% of about 1-8% and the linolic acid of about 0-5% usually derived from various animal-origin.Exemplary distribution be 2.5% tetradecanoic acid, 29% palmitinic acid, 23% stearic acid, the Zoomeric acid of 2%, the oleic acid of 41.5% and 3% linolic acid.Other similar mixtures, as from palmitic those and in being also included within from those of various Tallow, beef and lard.
Oleum Cocois refers to the fatty acid mixt of roughly carbon chain length distribution with 8% C8,7% C10,48% C12,17% C14,8% C16,2% C18,7% oleic acid and 2% linolic acid (enumerate the first six plant lipid acid be saturated).There is other source of similar carbon chain length distribution, as palm-kernel oil and babassu oil, be included in term Oleum Cocois.
Soap composition of the present invention comprise 0.01 to 5% one or more be selected from the antimicrobial acivity composition of active ingredients of essential oils and parachlormetaxylenol.Described active ingredients of essential oils is selected from phantol, vernol, Geraniol, terpinol, thymol and oxymethoxyallylbenzene.Preferred activeconstituents is selected from terpinol, thymol and oxymethoxyallylbenzene.Further preferred activeconstituents is terpinol or thymol.The most preferably mixture of terpinol and thymol.
Give the details of preferred active ingredients of essential oils hereinafter.
thymol
Shown below is the structure of thymol:
Composition of the present invention preferably comprises 0.01 to 5 % by weight, more preferably 0.01 to 1 % by weight, further more preferably 0.01 to 0.4 % by weight thymol, condition be soap composition of the present invention comprise 0.01 to 5 % by weight one or more be selected from the antimicrobial acivity composition of active ingredients of essential oils and parachlormetaxylenol.Thymol can add in said composition with purified form.Or, can the thyme oil or Thymi Serpylli Herba extract that comprise thymol be added in said composition, guarantee that thymol is present in composition of the present invention with desired concn simultaneously.Thyme oil or Thymi Serpylli Herba extract are available from Thymus vulgaris plant.Thymus vulgaris plant refers to the plant belonging to Thymus, and includes but not limited to following species: silver-colored spot Thymus vulgaris (
thymus vulgaris), foreign Thymus vulgaris (
thymus zygis), borneol Thymus vulgaris (
thymus satureoides), mastic Thymus vulgaris (
thymus mastichina),
thymus broussonetti,
thymus maroccanus,
thymus pallidus,
thymus algeriensis, Thymus serpyllum (
thymus serpyllum), wide leaf Thymus vulgaris (
thymus pulegoide) and Thymus citriodorata (
thymus citriodorus).
terpinol
Shown below is the structure of terpinol compound:
Terpinol is preferably selected from α-terpinol, β-terpinol, γ-terpinol or its mixture.Particularly preferably being this terpinol is α-terpinol.Terpinol can add in this antimicrobial composition with purified form.Or can the pine tar comprising terpinol be added in this antimicrobial composition, guarantee that terpinol is present in composition of the present invention with desired concn simultaneously.Said composition preferably comprises 0.01 to 5 % by weight, more preferably 0.02 to 5 % by weight, further more preferably 0.03 to 1 % by weight and even more preferably 0.04 to 0.6 % by weight terpinol, condition be soap composition of the present invention comprise 0.01 to 5 % by weight one or more be selected from the antimicrobial acivity composition of active ingredients of essential oils and parachlormetaxylenol.
oxymethoxyallylbenzene
Oxymethoxyallylbenzene is the methyl catechol that a kind of allyl group chain replaces.It extracts from some spices usually as cloves or Chinese cassia tree.Oxymethoxyallylbenzene has been used as perfume composition, for the preparation of seasonings, as sanitas or as local anesthetic.Composition of the present invention preferably comprises the oxymethoxyallylbenzene of 0.01 to 5 % by weight, preferably 0.02 to 1 % by weight, more preferably 0.03 to 0.4 % by weight, condition be soap composition of the present invention comprise 0.01 to 5 % by weight one or more be selected from the antimicrobial acivity composition of active ingredients of essential oils and parachlormetaxylenol.
Oxymethoxyallylbenzene has following structure:
geraniol
Shown below is the structure of Geraniol compound:
Geraniol is a monoterpenoid and a kind of fatty alcohol.It is the main ingredient of rose oil, rusa oil and pamorusa oil.It has the smell of recalling rose, and is usually used in perfume.Composition of the present invention preferably comprises the Geraniol of 0.01 to 5 % by weight, preferably 0.02 to 1 % by weight, more preferably 0.03 to 0.4 % by weight, condition be soap composition of the present invention comprise 0.01 to 5 % by weight one or more be selected from the antimicrobial acivity composition of active ingredients of essential oils and parachlormetaxylenol.
phantol
Shown below is the structure of phantol compound:
Phantol is a monoterpenoid and a kind of fatty alcohol.Phantol is produced more than 200 kind of plant, mainly come from Labiatae (herbaceous plant of peppermint, fragrance), Lauraceae (bay, Chinese cassia tree, dalbergia wood (rosewood)) and Rutaceae (citrus fruit), and birch and other plant, by the torrid zone to climate of frigid zone district.It has the happy fragrance of a flower and is usually used in perfume.Composition of the present invention preferably comprises the phantol of 0.01 to 5 % by weight, preferably 0.02 to 1 % by weight, more preferably 0.03 to 0.4 % by weight, condition be soap composition of the present invention comprise 0.01 to 5 % by weight one or more be selected from the antimicrobial acivity composition of active ingredients of essential oils and parachlormetaxylenol.
Said composition preferably can comprise the combination of thymol and terpinol with any preferred concentration above specified thymol and terpinol respectively.Such as, said composition preferably can comprise the mixture of the thymol of 0.01 to 0.6 % by weight of said composition and the terpinol of 0.02 to 1.5 % by weight.Composition of the present invention most preferably comprise the oxymethoxyallylbenzene of 0.01 to 0.4 % by weight of said composition, the thymol of 0.01 to 0.6 % by weight and 0.02 to 1.5 % by weight the mixture of terpinol.
PCMX
Shown below is the structure of PCMX compound:
Parachlormetaxylenol, also referred to as chloro-3, the 5-dimethyl phenols of PCMX or 4-, is for controlling the antimicrobial chemical compound of bacterium, algae and fungi in various product is as soap, paint vehicle and tackiness agent.Its anti-microbial effect is due to interference cell membrane potential.It has faint phenols smell.Composition of the present invention preferably comprises the PCMX of 0.01 to 5 % by weight, preferably 0.02 to 1 % by weight, more preferably 0.03 to 0.4 % by weight, condition be soap composition of the present invention comprise 0.01 to 5 % by weight one or more be selected from the antimicrobial acivity composition of active ingredients of essential oils and parachlormetaxylenol.
supplementary component
Composition of the present invention can optionally comprise washing composition activeconstituents, and it is selected from anionic, non-ionic type, cationic, both sexes or amphoteric ion type washing composition activeconstituents usually.If preferably use Non-soap detergent in the present compositions, described Non-soap detergent is selected from anionic or nonionic detergent active composition.Synthetic detergent contains the hydrophilic radical of relative polarity and the hydrophobic group of relative non-polarity.
The water soluble anionic detergent surfactant of expection is basic metal (as sodium and the potassium) salt of higher linear alkyl Phenylsulfonic acid and an alkali metal salt of sulfated ethoxylated and non-ethoxylized fatty alcohol and ethoxylated alkylphenol.
The specific sulfated surfactants of composition used in the present invention comprises sulfated ethoxylated and non-ethoxylized fatty alcohol, preferably has C
10-C
18, preferred C
12-C
16and if the words of alkyl group ethoxylation have straight chain unitary primary alconol or the secondary alcohol of every mol of alcohol average approximately 1-15, preferably 3-12 moles of ethylene oxide (EO), and have C
8-C
16alkyl group, preferably C
8-C
9the sulfated ethoxylated alkylphenol of alkyl group and the average 4-12 of every mole phenol mole EO.
The sulfated ethoxylated tensio-active agent of preferred classes is sulfated ethoxylated linear alcohols, as with on average about 1 to the C of about 12 moles of ethylene oxide ethoxylations
12-C
16alcohol.Most preferred sulfated ethoxylated detergent is by the C of sulfation with 3 moles of ethylene oxide ethoxylations
12-C
15alcohol obtains.
The specific nonionic surface active agent of composition used in the present invention comprises the fatty alcohol of ethoxylation, preferably has C
10-C
18, preferred C
12-C
16the straight chain unitary primary alconol of alkyl group and every mol of alcohol average approximately 1-15, preferably 3-12 moles of ethylene oxide (EO) or secondary alcohol, and there is C
8-C
16alkyl group, preferably C
8-C
9the ethoxylated alkylphenol of alkyl group and the average approximately 4-12 mole of EO of every mole phenol.
The nonionic surface active agent compound of preferred classes is ethoxylated linear alcohols, as with on average about 1 to the C of about 12 moles of ethylene oxide ethoxylations
12-C
16alcohol.Most preferred non-ionic detergent is the C with 3 moles of ethylene oxide ethoxylations
12-C
15alcohol.
The tensio-active agent of foregoing synthetic detergent type, the mixture of such as anionic and nonionic surface active agent or different specific anionics or nonionic surface active agent can be used for the detersive power of change said composition, bubbling character and other character.Such as, can by the mixture ethoxylation of the different fatty alcohol of 12 to 15 carbon atoms, direct sulfation or sulfation after ethoxylation, can by fatty alcohol moieties ethoxylation and sulfation, or by ethoxylated fatty acid Partial sulphation to obtain the mixture of anionic and nonionic surface active agent or different specific anionics or nonionic surface active agent.When it is present, tensio-active agent is preferably the 5-50 % by weight, more preferably 8 to 30 % by weight, further more preferably 10 to 25 % by weight of said composition.
Beneficial agent can be incorporated in the present compositions, such as wetting agent, softener, opalizer or anti-aging compound.The example of wetting agent and softener comprises wetting Agent for Printing Inks as polyvalent alcohol, glycerine, hexadecanol, carbomer, ethoxylated castor oil, paraffin oil, lanolin and derivative thereof.Also organic silicon compound can be included, such as organic silicon surfactant, if DC3225C(is from Dow Corning) and/or organosilicon softener, silicone oil (DC-200 from Dow Corning).Opalizer can also be incorporated to, as Avobenzone (can with trade(brand)name PARSOL 1789 available from Givaudan) and/or methoxy cinnamic acid 2-ethylhexyl (can with trade(brand)name PARSOL MCX available from Givaudan) or other UV-A and UV-B opalizer.Water soluble clycol, such as propylene glycol, ethylene glycol, glycerol can use with the content of the highest 10%.Can be incorporated to other additive, granulate material as water-fast in one or more, such as polysaccharide is as starch or treated starch and Mierocrystalline cellulose.Secondary additive comprises metal ion chelation agent or sequestering agent, colorant, sanitas and essence, is optionally incorporated to.Soap composition of the present invention can also containing the different compatible adjuvants measured.The representative instance of this type of compatible adjuvants is filler and pigment, as titanium dioxide, diatomite, arbitrary different tinting pigment, dyestuff, spices and optical whitening agent.
Said composition can in solid form (as rod, sheet, chip or powder) or in liquid form (as Liquid soap and bath composition) obtain.Said composition can be configured as frame system (casting) soap or development soap bar according to the general method of soapmaking technology.
manufacture the method for soap bar
The method according to exemplary manufacture soap bar according to the present invention will be described now.
The soap component of this soap bar by under atmospheric pressure mixing one or more lipid acid and at least one neutralizing agent and be heated to be enough to the temperature of this lipid acid of melting in open stirring reaction container, can be generally at least about 80 DEG C and manufactures to 90 DEG C.This lipid acid comprises lauric acid and has the mono carboxylic lipid acid of long alkyl chains of 14 carbon atom to 22 carbon atoms.The neutralizing agent being suitable for manufacturing soap bar of the present invention comprises caustic liquor, and such as soda is as NaOH.This neutralizing agent neutralizes this lipid acid, forms the salt (i.e. " soap ") of this lipid acid, as example sodium, potassium, ammonia or alkanol ammonium salt.This neutralizing agent can to add with the amount of dosage lower than neutralizing completely in needed for this lipid acid.In an exemplary of the present invention, about 95% of the amount neutralizing neutralizing agent needed for this lipid acid completely can be added.This temperature is preferably kept above about 80 DEG C but lower than about 100 DEG C.
Optionally at this moment, the free acid of this mixture can be analyzed, and correspondingly regulate the pH of this mixture.Such as, this mixture of pH indicator NaOH titration can be used, and when needs, the composition of this mixture can be regulated to have to make 10% aqueous solution of gained soap bar the pH being not more than about 9.Such as, if this pH is too acid, more neutralizing agents can be added.Or, if this mixture has the pH higher than about 9, more free fatty acidies can be added in said composition.If add free fatty acids, preferably this free fatty acids has the alkyl chain of 8 to 10 carbon atoms.
At this one-phase of manufacture method, the temperature of reaction mixture can bring up at least about 90 DEG C, preferably approximately 90 DEG C to about 100 DEG C to evaporate the water of aequum.Or this water can at the front evaporator adding extra neutralizing agent or free fatty acids as mentioned above.In one embodiment of the invention, this soap bar comprises the water being no more than 25%.This soap bar preferably comprises the water being no more than 20%.More preferably, this soap bar comprises the water being no more than 15%.When removing the water of aequum from soap component, this soap component can be cooled, ordinary method then can also be used to be added by the optional member of interpolation
To in this soap component.Resulting composition can by being configured as soap bar by the said composition impouring mould of molten state, or use conventional development, mold pressing and/or punching press program to form soap bar as known in the art.
sterilization method
According to a second aspect of the invention, provide a kind of method of disinfecting surface, comprise the following steps:
A. composition of the present invention is applied to this on the surface; With
B. said composition is removed on the surface from this.
This surface is skin preferably.Thus, make such as similar hand, face, the surface in health or oral cavity contacts with composition of the present invention.Or this surface is any crust.Usually, this type of crust usually needs the clean and preferred surface also needing sanitary measure or sterilization.This type of surface can be found in many families or industrial environment, and can comprise such as kitchen and bathroom surfaces, table top, floor, metope, window, vessel, tableware and pottery.This type of surface can be made up of many differing materials, comprises such as plastics, timber, metal, pottery, glass, concrete, marble and painted surface.
Said composition can be applied to this on the surface by any appropriate means well known by persons skilled in the art.Such as, when liquid composition, suitable means can be topple over, drip, spray or wiping.
Before the method is preferably included in and said composition is applied to this surface or simultaneously with suitable solvent, preferably water dilution or dissolve said composition.Especially when said composition is solids composition, this dissolving is preferred.Or, can also (such as in powder form) directly spreading, friction or spray this solids composition.
The method of first aspect present invention also comprises removes the step of said composition on the surface from this.Here, remove said composition and also comprise part removal said composition, because the said composition of trace may remain on a surface.In many typical situations, comprise washed skin or hard-surface cleaning, if a part of said composition, particularly some activeconstituents remains is acceptable or sometimes even desirable on a surface.Therefore, step b preferably include removal by weight at least 5%, more preferably at least 10%, even more preferably at least 25%, more more preferably at least 50% and also more preferably at least 75% said composition.Removing the step of said composition preferably includes with this surface of suitable solvent washing or with this surface of suitable wipe, and more preferably, this step is by rinsing this surface with suitable solvent or with this surface composition of suitable wipe.Such as, or this removal step can also comprise a part of said composition of evaporation, when said composition comprises volatile constituent such as solvent.
The medium being suitable for rinsing this surface is water, but also can be the mixture of such as water and alcohol.After a predetermined time period, its immediately preferred with enough water rinse with any visible or appreciable resistates removing said composition.Or, this surface of wipe of alcohol swab or water/alcohol dipping can be used visually there is not this antimicrobial composition.Due to composition of the present invention anti-microbial effect fast surprisingly, the step (such as by rinsing or this surface of wiping) removing said composition is preferably less than 5 minutes after said composition applying step on a surface being started, more preferably less than 2 minutes, even more preferably less than 1 minute, again more preferably less than 30 seconds and also more preferably less than 20 seconds in start.Almost can occur instantaneously when applying composition of the present invention even if topical microbial is killed, preferably from after this step removing said composition is on the surface said composition being applied step on a surface at least 5 seconds, preferably at least 10 seconds, more preferably at least 15 seconds time start to realize best anti-microbial effect.The timed interval that these ageings become also is preferred.Therefore, particularly preferably be, (namely step b) (namely step a) between latter 2 minutes and 5 seconds, more preferably more preferably starts between 20 seconds and 15 seconds between 30 seconds and 10 seconds and again between 1 minute and 10 seconds, even more preferably said composition being applied step on a surface the step removing said composition on the surface from this.
Method of the present invention is preferably the sterilization method of non-treatment.
purposes of the present invention
Be preferably non-treatment benefit and the present invention is provided.Therefore, such as, the present invention relates to antimicrobial composition of the present invention for reducing the purposes of viable microbial organisms counting sooner.
Thus, according to a third aspect of the invention we, the purposes of health of composition of the present invention for improving is provided.This type of purposes relates to such as reducing viable microbial organisms counting, preferably reducing the purposes of viable microbial organisms counting fast.Thus, the purposes of this type of purposes preferably in sterilization method.
Thus, composition of the present invention is provided for improving the purposes of human body surface health.This type of surface comprises such as skin, hand and oral cavity.According to a preferred aspect, the present invention relates to composition of the present invention for improving the purposes of hand hygiene.According to another preferred aspect, the present invention relates to composition of the present invention for improving the purposes of oral hygiene.
In order to more completely understand the present invention and not by the mode of restriction, with reference to the following example.But, it will be appreciated by the skilled addressee that and can carry out various amendment and change when not leaving scope of the present invention.Therefore, this embodiment is considered to illustrative and nonrestrictive meaning, and this type of amendments all are intended within the scope of the present invention.
Embodiment
embodiment A, B and embodiment 1: the synergy between sodium laurate and antimicrobial acivity composition
Preparation display composition in Table 1 also uses following its anti-microbial activity of program test of summarizing.
scheme: contact sterilize experiment (contact in 15 seconds is killed)
Test organisms
e.coliaTCC 10536 in TSA plate (Difco – 40 grams per liter) (gpl) at 37 DEG C through 16-18 hours growth whole night.Cell density is adjusted to acquisition 10
8cfu/ml(is 0.8 OD under 620 nm) final counting.In sampling receptacle, take 9 milliliters of test solns, and add the culture of 1 milliliter of process wherein.After the duration of contact of 15 seconds, with 1 milliliter of said mixture in immediately in D/E meat soup (Difco-39gpl).Serial dilution is carried out and duplicate at TSA(Difco-40gpl in D/E meat soup) upper transplating board.In contrast situation, 1 milliliter of test cultures to be added in 9 mL of saline and serial dilution and at TSA upper transplating board.After solidification, this plate is cultivated 48 hours at 37 DEG C.After 48 hours of incubation residue bacterium colony is counted, and by comparing to come compute power with contrast.Calculate logarithm by the log value deducting test soln from cultivation contrast to reduce.
Table 1
| Embodiment | Composition | Logarithm reduces |
| A | 0.0625% terpinol+0.025% thymol | 0.17 |
| B | 0.5% sodium laurate | 0.33 |
| 1 | 0.0625% terpinol+0.025% thymol+0.5% sodium laurate | 7.22 |
Digital proof in upper table 1, between the mixture and the sodium laurate of lower concentration of thymol and terpinol, there is Synergistic antimicrobial activity, wherein the mixture of thymol and terpinol has low antimicrobial acivity.
embodiment C, D and embodiment 2 to 5: the synergy under the existence of soap between sodium laurate and antimicrobial acivity composition
Preparation amounts to the soap composition containing 70% soap.Said composition comprises the terpinol of 0.5% and the thymol of 0.2%.The sodium laurate amount of the % form of soap total amount is set forth in following table 2.Measure the program of anti-microbial activity and identical for embodiment 1.Data are summarised in following table 2.
Table 2
| Embodiment | Antimicrobial acivity | Sodium laurate (wt% of total soap content) | Logarithm reduces |
| C | Do not exist | 9.2 | 0.29 |
| D | Exist | 9.2 | 2.58 |
| 2 | Exist | 13.7 | 4.16 |
| 3 | Exist | 18.3 | 5.20 |
| 4 | Exist | 20.1 | 5.31 |
| 5 | Exist | 22.8 | 7.9 |
Data in upper table 2 show, when not using antimicrobial acivity composition (Embodiment C) or exceeding claimed scope when sodium laurate amount, antimicrobial acivity is low.But, when sodium laurate amount is in claimed scope, obtain excellent antimicrobial acivity.
embodiment E is to I and 6 to 9: the synergy proving other antimicrobial acivity composition and sodium laurate
In table 3, other antimicrobial acivity compositions various of display use together with sodium laurate and adopt with identical method used in embodiment 1 to measure antimicrobial acivity.Data are summarized in table 3.
Table 3
| Embodiment | Antimicrobial acivity composition (wt%) | Sodium laurate (wt%) | Logarithm reduces |
| E | Do not exist | 0.5% | 1.04 |
| F | To chloro-m-xylene (0.1%) | Do not exist | 0.15 |
| 6 | To chloro-m-xylene (0.1%) | 0.5% | 7.51 |
| G | Geraniol (0.1%) | Do not exist | 0.49 |
| 7 | Geraniol (0.1%) | 0.5% | 7.51 |
| H | Vernol (0.1%) | Do not exist | 0.52 |
| 8 | Vernol (0.1%) | 0.5% | 7.84 |
| I | Phantol (0.1%) | Do not exist | 0.26 |
| 9 | Phantol (0.1%) | 0.5% | 7.84 |
Data in upper table 3 show, being used alone sodium laurate (embodiment E) or being used alone some antimicrobial acivity composition (embodiment F is to I) claimed in the present invention to provide good antimicrobial acivity.But these combination (embodiment 6 to 8) provides Synergistic antimicrobial activity.
embodiment J to W: lack active embodiment when showing to use the tensio-active agent except sodium laurate
As shown in table 4, use other aniorfic surfactant various (comprising various soap active substance) together with antimicrobial acivity composition (terpinol of 0.05% and the thymol of 0.02%), but all do not show the activity shown by lauroleate.The program identical with embodiment 1 is used to obtain data in table 4.
Table 4
| Embodiment | Antimicrobial acivity | Tensio-active agent (wt%) | Logarithm reduces |
| J | Exist | Do not exist | 0.13 |
| K | Do not exist | 0.4% sodium laurate | 0.04 |
| 10 | Exist | 0.4% sodium laurate | 5.57 |
| L | Do not exist | 0.5% Sodium pentadecanecarboxylate | 0.28 |
| M | Exist | 0.5% Sodium pentadecanecarboxylate | 0.69 |
| N | Do not exist | 0.5% sodium oleate | 0.35 |
| O | Exist | 0.5% sodium oleate | 0.42 |
| P | Do not exist | 0.5% Sodium tetradecanoate | 0.32 |
| Q | Exist | 0.5% Sodium tetradecanoate | 2.78 |
| R | Do not exist | 0.5% Sodium octoate | 0.20 |
| S | Exist | 0.5% Sodium octoate | 0.16 |
| T | Do not exist | 0.5% sodium stearate | 0.20 |
| U | Exist | 0.5% sodium stearate | 0.59 |
| V | Do not exist | 0.5% Sodium Lauryl Sulphate BP/USP | 0.27 |
| W | Exist | 0.5% Sodium Lauryl Sulphate BP/USP | 1.27 |
Data in table 4 show, only use sodium laurate and antimicrobial acivity composition (embodiment 10) to provide synergistic activity, and various similar soap or aniorfic surfactant (embodiment J to W) can not show required high reactivity level.
By description above, become apparent, to describe in this article and exemplified with a kind of newly with effective soap composition, it achieves some preceding aim.
Present invention thus provides the collaborative soap composition producing excellent anti-microbial activity.
Although describe the present invention with reference to particular, it will be appreciated by those skilled in the art that the present invention can embody with other forms many.
Claims (11)
1. soap composition, it comprises:
A) soap of 15 to 80 % by weight;
B) one or more antimicrobial acivity compositions of 0.01 to 5 % by weight, described antimicrobial acivity composition is selected from active ingredients of essential oils and parachlormetaxylenol;
12 to 50 % by weight of wherein said soap is lauric salt;
Wherein said active ingredients of essential oils is selected from phantol, vernol, Geraniol, terpinol, thymol, oxymethoxyallylbenzene and composition thereof.
2. composition as claimed in claim 1, wherein said antimicrobial acivity composition is the mixture of terpinol and thymol.
3. solid soap composition as claimed in claim 1 or 2, wherein said soap is 40 to 80 % by weight of described composition.
4. the liquid soap composition as described in aforementioned any one of claim, wherein said soap is 15 to 30 % by weight of described composition.
5. the composition as described in aforementioned any one of claim, wherein said lauric salt is 12 % by weight to 25 % by weight of described soap.
6. the composition as described in aforementioned any one of claim, wherein said lauric salt is sodium laurate or potassium laurate.
7. the method for disinfecting surface, it comprises the following steps:
A. on surface as described in the composition as described in any one of claim 1 to 6 being applied to; With
B. described composition is removed from described surface.
8. method as claimed in claim 7, wherein said surface is skin surface.
9. method as claimed in claim 7 or 8, wherein starts, between latter 2 minutes and 5 seconds, more preferably between 1 minute and 10 seconds, even more preferably more preferably to start described step (b) between 20 seconds and 15 seconds between 30 seconds and 10 seconds and again described step (a).
10. the composition as described in any one of claim 1 to 6 is for improving the purposes of hand hygiene.
11. compositions as described in any one of claim 1 to 6 are for improving the purposes of oral hygiene.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12183546.6 | 2012-09-07 | ||
| EP12183546 | 2012-09-07 | ||
| PCT/EP2013/066144 WO2014037167A1 (en) | 2012-09-07 | 2013-08-01 | Soap composition |
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| Publication Number | Publication Date |
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| CN104736687A true CN104736687A (en) | 2015-06-24 |
| CN104736687B CN104736687B (en) | 2018-03-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201380057276.7A Active CN104736687B (en) | 2012-09-07 | 2013-08-01 | Soap composition |
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| Country | Link |
|---|---|
| EP (1) | EP2892991B1 (en) |
| CN (1) | CN104736687B (en) |
| BR (1) | BR112015004813B1 (en) |
| IN (1) | IN2015MN00414A (en) |
| WO (1) | WO2014037167A1 (en) |
| ZA (1) | ZA201501542B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108366925A (en) * | 2015-11-27 | 2018-08-03 | 荷兰联合利华有限公司 | antimicrobial cleansing compositions |
| CN113475539A (en) * | 2021-06-23 | 2021-10-08 | 杭州微冠科技有限公司 | Preparation method of transparent soap shoe cover epidemic prevention isolation rubber mat |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2902011T3 (en) * | 2014-02-04 | 2018-06-29 | Basf Se | Aqueous tenside compositions |
| US10449137B2 (en) | 2015-12-14 | 2019-10-22 | Conopco, Inc. | Antimicrobial composition |
| CN113416617A (en) * | 2021-06-23 | 2021-09-21 | 杭州微冠科技有限公司 | Transparent soap key isolation rubber pad |
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- 2013-08-01 WO PCT/EP2013/066144 patent/WO2014037167A1/en active Application Filing
- 2013-08-01 CN CN201380057276.7A patent/CN104736687B/en active Active
- 2013-08-01 BR BR112015004813-7A patent/BR112015004813B1/en active IP Right Grant
- 2013-08-01 EP EP13745052.4A patent/EP2892991B1/en not_active Not-in-force
- 2013-08-01 IN IN414MUN2015 patent/IN2015MN00414A/en unknown
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| US2196763A (en) * | 1938-01-21 | 1940-04-09 | Eastman Kodak Co | Liquid antiseptic soap |
| CN1236387A (en) * | 1996-11-09 | 1999-11-24 | 雷克特和科尔曼产品有限公司 | Antiseptic soap bar |
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| CN113475539A (en) * | 2021-06-23 | 2021-10-08 | 杭州微冠科技有限公司 | Preparation method of transparent soap shoe cover epidemic prevention isolation rubber mat |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201501542B (en) | 2016-10-26 |
| IN2015MN00414A (en) | 2015-09-04 |
| BR112015004813A8 (en) | 2019-08-13 |
| CN104736687B (en) | 2018-03-02 |
| BR112015004813B1 (en) | 2021-02-02 |
| EP2892991B1 (en) | 2016-03-02 |
| BR112015004813A2 (en) | 2017-07-04 |
| WO2014037167A1 (en) | 2014-03-13 |
| EP2892991A1 (en) | 2015-07-15 |
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