CN104736687B - Soap composition - Google Patents
Soap composition Download PDFInfo
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- CN104736687B CN104736687B CN201380057276.7A CN201380057276A CN104736687B CN 104736687 B CN104736687 B CN 104736687B CN 201380057276 A CN201380057276 A CN 201380057276A CN 104736687 B CN104736687 B CN 104736687B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/02—Compositions of detergents based essentially on soap on alkali or ammonium soaps
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/28—Organic compounds, e.g. vitamins containing halogen
Abstract
The present invention relates to soap composition, the more particularly to personal wash compositions with Synergistic antimicrobial activity.It has been found by the present inventors that when soap composition includes 12 50% sodium laurate for accounting for total soap percentage being used together with some antimicrobial acivity compositions, Synergistic antimicrobial activity is shown.
Description
Invention field
The present invention relates to soap composition, the more particularly to personal wash compositions with Synergistic antimicrobial activity.
Background of invention and prior art
Specification in the whole text in any discussion to prior art be not construed as recognizing that the prior art is known or formed
A part for general knowledge known in this field.
Personal wash compositions can obtain in a variety of manners, and such as soap bar, transparent soap bar, it includes pouring casting rod（cast-
bar）, liquid soap, it includes hand cleanser composition, creams and gel base product.Commercially available soap composition has one or more
" soap ", it has implication as commonly understood in the art：The salt of mono carboxylic aliphatic acid.The counter ion counterionsl gegenions of the salt be typically sodium,
Potassium, ammonium or alkanol ammonium ion, but other suitable ions known in the art can also be used.Composition based on soaps, i.e. soap
Bar, the alkali metal salt of 15 to 80 weight % aliphatic acid is usually contained, depending on the soap composition is solid or liquid form,
It forms total fatty material（TFM）, remainder is water（About 10-20%）With other compositions such as metal ion chelation agent, color
Material, essence, preservative etc..Structural agent and filler are also usually added to substitute a part of soap in such composition, together on a small quantity
When keep product required property.The soap bar that TFM contents are about 70% is referred to as " perfumed soap（toilet soap）", and TFM is big
Those of about 40% are referred to as " bath soap（bathing bar）”.
The microorganism of several types in an atmosphere be present, such as bacterium, virus and mould, some of them are liked in human body skin
Upper existence and breeding.These the biological parts resided on human body skin can cause unacceptable symptom, such as body odor, papule
（pimple）And acne（acne）, this is being cosmetically that people is unacceptable.These symptoms are entered because of heat and moist weather conditions
One step is aggravated.A kind of method for eliminating these microorganisms resided on skin is that washing group is preferably used when having a bath or washing one's hands
Compound such as soap washes them off.
Soap is known per se to have anti-microbial properties.In addition, the sterilization soap composition of formulated is also in this area
Know, it is used to treat serious disease of skin such as scabies.In order to provide antimicrobial benefits, bactericide or antibacterial via soap composition
Agent such as triclosan（I.e. 2,4,4 '-three chloro- 2 '-hydroxy-diphenylethers；TCN）And triclocarban（TCC）It is known and has made
With.It is also desirable that anti-microbial effect is provided in the short time range that most people is cleaned, the short time chi
Spend for less than one minute, sometimes less than half a minute.The antimicrobial compositions of combination comprising active ingredients of essential oils（It is basic herein
On be prepared for soaps）And it is known, and a kind of such composition is disclosed in WO 2010046238.
In aliphatic acid, the laurate for being typically derived from coconut oil has been used to soapmaking.Coconut oil is generally with whole oil/greases
About the 20% of fat acid blend uses, and such coconut oil mass causes the soap composition to have about 10% laurate.
The composition for including high lauric acid soap content has been reported in WO 07065538.
Present inventors have surprisingly discovered that the lauric acid soap comprising specified quantitative and specific antimicrobial acivity into
The soap composition divided the cooperative interaction of the soap and active component because providing excellent antimicrobial acivity.
Therefore, it is an object of the invention to come with being substantially less than heretofore known antimicrobial acivity composition concentration offer
From the anti-microbial properties of the enhancing of soap.
Another object of the present invention is that the anti-microbial properties of enhancing are provided in relatively short time range.
It is also another object of the present invention to provide comprising being easily obtained and being easy to be mixed into the composition in said composition, thus protect
Hold the personal wash compositions of low cost.
Summary of the invention
The first aspect of the present invention is related to a kind of soap composition, and it is included：
a）15 to 80 weight % soap；
b）0.01 to 5 weight % one or more antimicrobial acivity compositions, the antimicrobial acivity composition are selected from essence
Oily active component and parachlorometaxylenol；
12 to 50 weight % of wherein described soap are lauric salt；
Wherein the active ingredients of essential oils be selected from linalool, nerol, geraniol, terpineol, thymol, eugenol and its
Mixture.
The lauric salt is preferably sodium laurate or potassium laurate.
According to the second aspect of the invention, there is provided the method for disinfecting surface, it comprises the following steps：
A. the composition of the present invention is applied on the surface；With
B. said composition is removed from the surface.
In the third aspect, the purposes for improving health is used for the invention provides the composition of the present invention.
Detailed description of the invention
By reading as detailed below and appended claims, these and other aspects, features and advantages will be common to this area
Technical staff becomes apparent.To avoid query, any feature of one aspect of the invention can be used for the present invention it is any its
Its aspect.Word "comprising" be intended to refer to " comprising " but be not necessarily " by ... form " or " composition ".In other words, it is listed
Step or selection need not be exhaustive.It should be noted that the example provided in following specification is intended to illustrate the present invention, rather than
It is intended to limit the invention to those examples in itself.Similarly, all percentages are weight/percentage by weight, unless otherwise specified.
Except operate and comparative example in, quantity of material or anti-is represented or when separately clearly stating, in this specification
All numerals of condition, the physical property of material and/or purposes are answered to be interpreted as being modified by word " about ".Unless separately say
Bright, " digital scope in x to y " is interpreted as including x and y form.When for specific features, with form, " x to y " descriptions are multiple excellent
When selecting scope, it is interpreted as it is also contemplated that having arrived all scopes of the different end points of combination.
Antimicrobial compositions used herein are referred to including being used to cleaning and sterilizing regional area, such as lactation is moved
Thing（The particularly mankind）Skin and/or hair composition.Such composition, soap is included according to the present invention, and it is therefore usual
It is a kind of cleaning-type Cleasing compositions, it can be additionally used for improving outward appearance, control for smell or examined for overall aesthetic
Amount.The composition of the present invention can be liquid form, but can be changed with including lotion, creams, foam or gel, or
Toner, or apply using instrument or via facial mask, pad or patch.Said composition is preferably solid form.Herein
" skin " used refer to including on the face with the skin on body（Such as neck, chest, back, arm, oxter, hand, leg,
Buttocks and scalp）.When with provide sterilize and cleaning specific purpose prepare the product when, composition of the invention also with human body
Application of any other cutin substrate in addition to the skin for example on hair is related.
The composition of the present invention can be with any preparation for the product form hereinafter enumerated, and it is each defined as follows.
Soap bar refers to the composition of shaped solid form, and it includes the salt of soap, i.e. aliphatic acid.Soap bar can be by developing and being molded
（milled and plodded）Route is prepared by founding route.Liquid personal cleansing composition refers to being used for various
The Liquid form compositions of hair are such as washed one's hands, take a shower, wash one's face or cleaned to people's clean applications.
Antibacterial soap compositions and personal wash compositions are well known in the art.Such composition can be with various products
Form obtains, such as perfumed soap, bath soap, hand cleanser, bath foam and antibacterial soap lye wet tissue.The health consciousness of raising, is constantly carried in addition
High city and the country of rural health and international standard, cause the wilderness demand to such product.Antibacterial soap compositions
Using the people for being not limited only to live in rural area, also turn into one of the daily hygiene plan for the people for living in modern metropolitan cities
Point.
Soap is defined as the salt of aliphatic acid, and it is by using alkali, in sodium hydroxide, potassium hydroxide, ammonium hydroxide or triethylamine
Prepared with corresponding aliphatic acid.The alkali metal salt of carboxylic acid is required by using containing with corresponding aliphatic acid in alkali or with alkali process
The oil of aliphatic acid composition（Triglycerides）To prepare.Later approach is commonly referred to as saponification.Alkali used is corresponding metal
Hydroxide or metal carbonate.Coconut oil and palm-kernel oil are rich in laurate, therefore also are used as used according to the invention
The precursor of laruate.The alkali metal salt of the present invention is preferably selected from sodium salt, sylvite or its mixture.If as described in the present invention
Using sodium salt, resulting composition can be used for preparing solid soap.On the other hand, sylvite causes more soft product, works as required product
This is especially preferred when being liquid soap.The mixture of sodium salt and sylvite causes the production of the hardness/pliability with intermediate degree
Product, those skilled in the art can be correctly balanced the ratio as needed.
Soap has certain antimicrobial acivity in itself, and this can be according to by the present invention in that use antimicrobial acivity composition
To further enhance.
Soap in the soap composition of the present invention generally comprises the part that is made up of laruate soap and by non-lauric hydrochlorate soap
Another part of composition.When coconut oil or coconut fatty acid are used as the precursor of laruate soap, distilled fatty acid blend
Saponification can generate non-lauric hydrochlorate soap component in compound soap.
Distilled fatty acid（DFA）Mixtures of the C14 to C18 aliphatic acid, it include myristic acid, palmitic acid, stearic acid,
Oleic acid, linoleic acid plus linolenic acid.Personal wash compositions are 80 generally by using weight ratio:20 to 20:80 coconut oil soap
Combination with DFA soaps manufactures.The ratio can be changed to realize required result.
The inventors have discovered that and confirm, in the laruate soap containing specified quantitative（The 15 to 50% of soap gross weight）With
And surprising synergy in the composition of specific antimicrobial acivity composition be present.Both shows excellent when combining
Different antimicrobial efficacy, this can provide bigger benefit to user.
The present invention relates to soap composition, and it includes 15 to 80 weight % soap and 0.01 to 5% one or more resist micro- life
Thing active component, the antimicrobial acivity composition are selected from active ingredients of essential oils and parachlorometaxylenol；Wherein described soap
12 to 50 weight % are lauric salt.
The composition of the present invention includes 15 to 80 weight % soap.When the soap composition is solid form, it is preferably comprised
40 to 80 weight %, more preferably 55 to 76 weight % soap.When said composition is liquid form, it preferably comprises 15 to 30%
Soap, more preferably 15 to 20% soap.According to the present invention, the lauric salt preferably comprises soap total amount present in said composition
12 to 25 weight %.
Laurate is a kind of mono carboxylic aliphatic acid with 12 carbon atoms.Lauric IUPAC titles are " n-dodecanes
Acid ".It is found in the degree actually existed in palm-kernel oil and coconut oil to about 50%.Term " lauric salt "
For the bay acid derivative for describing to neutralize using alkali/basic matterial.The salt is preferably lithium, sodium, potassium, calcium, magnesium, ammonium, triethyl group
Ammonium or tri ethanol ammonium salt；The salt is more preferably sodium laurate or potassium laurate.Suitable group of sodium salt and sylvite can also be used
Close without departing from the scope of the present invention.
Term total fatty material（It is commonly abbreviated as TFM）Aliphatic acid and triglycerides for representing to be present in soaps is residual
Base relative to all compositions percentage by weight, without considering associated cation.
The soap can be obtained by saponified fat/oil and/or aliphatic acid.Being generally used for the fatty or oily of soapmaking can be
Such as tallow, tallow stearines, palm oil, palm stearin, soybean oil, fish oil, castor oil, rice bran oil, sunflower oil, coconut oil, bar
Ba Su oil, palm-kernel oil and other.In the above methods, the fatty acid derived is from selected from coconut, rice bran, peanut, tallow, palm fibre
The oil/grease fat of palmitic acid, palm kernel, cottonseed, soybean, castor-oil plant etc..
The fatty acid soaps can be with synthetically prepared（Such as hydrogenate carbon monoxide by the oxidation of oil or by fischer tropsch process）.
Resin acid can be used, as being present in tall oil.Aphthenic acids is also suitable.
Tallow fatty acids can be derived from various animal origins and generally comprise about 1-8% myristic acid, about 21-
32% palmitic acid, about 14-31% stearic acid, about 0-4% palmitoleic acid, about 36-50% oleic acid and about 0-5%
Linoleic acid.Exemplary distribution be 2.5% myristic acid, 29% palmitic acid, 23% stearic acid, 2% palmitoleic acid, 41.5%
Oleic acid and 3% linoleic acid.Other similar mixtures, as from palm oil and from various tallows and lard
In those are also included within.
Coconut oil refers to thering is 8% C8,7% C10,48% C12,17% C14,8% C16,2% C18,7% oleic acid and 2%
Linoleic acid（The first six the kind aliphatic acid enumerated is saturation）Substantially carbon chain length distribution fatty acid mixt.With similar carbon
Other sources of chain length distribution, such as palm-kernel oil and babassu oil, are included in term coconut oil.
The one or more that the soap composition of the present invention includes 0.01 to 5% are selected from active ingredients of essential oils and to diformazan between chlorine
The antimicrobial acivity composition of phenol.The active ingredients of essential oils is selected from linalool, nerol, geraniol, terpineol, thymol
And eugenol.Preferred active component is selected from terpineol, thymol and eugenol.Active component even more preferably
It is terpineol or thymol.The most preferably mixture of terpineol and thymol.
The details of preferred active ingredients of essential oils has been given below.
Thymol
It shown below is the structure of thymol：
The composition of the present invention preferably comprises 0.01 to 5 weight %, more preferably 0.01 to 1 weight %, even more preferably
0.01 to 0.4 weight % thymol, condition are that the one or more that the soap composition of the present invention includes 0.01 to 5 weight % are selected from
The antimicrobial acivity composition of active ingredients of essential oils and parachlorometaxylenol.Thymol can be added to the group with purified form
In compound.Or the thyme linaloe oil comprising thymol or thyme extract can be added in said composition, ensure simultaneously
Thymol is present in required concentration in the composition of the present invention.Thyme linaloe oil or thyme extract are obtained from thyme plant.
Thyme plant refers to the plant for belonging to Thymus, and including but not limited to following species：Silver-colored spot thyme（Thymus vulgaris）, Thymuszygis（Thymus zygis）, borneol thyme（Thymus satureoides）, mastic thyme
（Thymus mastichina）、Thymus broussonetti、Thymus maroccanus、Thymus pallidus、Thymus algeriensis, Thymus serpyllum（Thymus serpyllum）, wide leaf thyme（Thymus pulegoide）With
Lemon thyme（Thymus citriodorus）.
Terpineol
It shown below is the structure of terpin alcoholic compound：
Terpineol is preferably selected from α-terpineol, β-terpineol, γ-terpineol or its mixture.The particularly preferably terpene
Product alcohol is α-terpineol.Terpineol can be added in the antimicrobial compositions with purified form.Or it can will include terpene
The pine tar of product alcohol is added in the antimicrobial compositions, while ensures that terpineol is present in the combination of the present invention with required concentration
In thing.Said composition preferably comprises 0.01 to 5 weight %, more preferably 0.02 to 5 weight %, even more preferably 0.03 to 1 weight %
Even more preferably 0.04 to 0.6 weight % terpineol, condition are that the soap composition of the present invention includes the one of 0.01 to 5 weight %
Kind or a variety of antimicrobial acivity compositions selected from active ingredients of essential oils and parachlorometaxylenol.
Eugenol
Eugenol is a kind of guaiacol of pi-allyl chain substitution.It generally extracts from some spices such as cloves or meat
Osmanthus.Eugenol already function as perfume composition, for preparing flavor enhancement, as preservative or as local anesthetic.The present invention
Composition preferably comprise 0.01 to 5 weight %, preferably 0.02 to 1 weight %, more preferably 0.03 to 0.4 weight % eugenol,
Condition is that the one or more that the soap composition of the present invention includes 0.01 to 5 weight % are selected from active ingredients of essential oils and between chlorine two
The antimicrobial acivity composition of cresols.
Eugenol has following structure：
Geraniol
It shown below is the structure of spiceleaf alcoholic compound：
Geraniol is a monoterpenoid and a kind of aliphatic alcohol.It is the key component of attar of rose, palmarosa oil and citronella oil.
It has the smell of recalling rose, and is generally used in perfume.The composition of the present invention preferably comprises 0.01 to 5 weight %, preferably
0.02 to 1 weight %, more preferably 0.03 to 0.4 weight % geraniol, condition are that the soap composition of the present invention includes 0.01 to 5 weight
The one or more for measuring % are selected from the antimicrobial acivity composition of active ingredients of essential oils and parachlorometaxylenol.
Linalool
It shown below is the structure of linalool compound：
Linalool is a monoterpenoid and a kind of aliphatic alcohol.Produce life linalool is planted more than 200 kinds, mostlys come from lip
Section（Peppermint, the herbaceous plant of fragrance）, Lauraceae（Bay, Chinese cassia tree, dalbergia wood（rosewood））And Rutaceae（Citrus fruit）, with
And birch and other plants, by the torrid zone to climate of frigid zone area.It has the happy fragrance of a flower and is generally used in perfume.The present invention's
Composition preferably comprises 0.01 to 5 weight %, preferably 0.02 to 1 weight %, more preferably 0.03 to 0.4 weight % linalool, condition
It is that the one or more that soap composition of the invention includes 0.01 to 5 weight % are selected from active ingredients of essential oils and to chloro-m-xylene
The antimicrobial acivity composition of phenol.
Said composition preferably above can include hundred to any preferred concentration as defined in thymol and terpineol respectively
In phenol and terpineol combination.For example, said composition can preferably comprise 0.01 to 0.6 weight % of said composition thymol
With the mixture of 0.02 to 1.5 weight % terpineol.The composition of the present invention most preferably comprises the 0.01 to 0.4 of said composition
The mixture of the terpineol of weight % eugenol, 0.01 to 0.6 weight % thymol and 0.02 to 1.5 weight %.
PCMX
It shown below is the structure of PCMX compounds：
Chloro- 3, the 5- dimethyl phenols of parachlorometaxylenol, also referred to as PCMX or 4-, it is in various products such as soap, paint vehicle
With in adhesive be used for control bacterium, algae and fungi antimicrobial chemical compound.Its antibacterial action is due to that interference is thin
After birth current potential.It has faint phenols smell.The composition of the present invention preferably comprises 0.01 to 5 weight %, preferably 0.02 to 1
Weight %, more preferably 0.03 to 0.4 weight % PCMX, condition are one kind that the soap composition of the present invention includes 0.01 to 5 weight %
Or a variety of antimicrobial acivity compositions selected from active ingredients of essential oils and parachlorometaxylenol.
Supplementary element
The present invention composition can optionally include detergent active component, its be generally selected from anionic, nonionic,
Cationic, both sexes or amphoteric ion type detergent active component.It is preferable that in the present compositions using non-
If soaps detergent, the Non-soap detergent is selected from anionic or nonionic detergent active composition.Synthesis of detergent
Agent contains the hydrophilic radical of relative polarity and the hydrophobic group of relative non-polarity.
Expected water soluble anionic detergent surfactant is the alkali metal of higher linear alkyl benzene sulfonic acid（Such as sodium and
Potassium）Salt and sulfated ethoxylated and the alkali metal salt of non-ethoxylized fatty alcohol and ethoxylated alkylphenol.
Specific sulfated surfactants available for the composition of the present invention include sulfated ethoxylated and non-ethoxy
Base fatty alcohol, preferably with C10-C18, preferably C12-C16Alkyl group and having if ethoxylation is put down per mol of alcohol
About 1-15, preferably 3-12 moles of ethylene oxide（EO）Straight chain unitary primary alconol or secondary alcohol, and there is C8-C16Alkyl base
Group, preferably C8-C9The sulfated ethoxylated alkylphenol of alkyl group and every average 4-12 moles of EO of mole phenol.
The sulfated ethoxylated surfactant of preferred classes is sulfated ethoxylated linear alcohols, such as with averagely about
The C of 1 to about 12 moles of ethylene oxide ethoxylation12-C16Alcohol.Most preferred sulfated ethoxylated detergent passes through sulfuric acid
Change the C with 3 moles of ethylene oxide ethoxylations12-C15Alcohol is made.
Specific nonionic surface active agent available for the composition of the present invention includes the fatty alcohol of ethoxylation, excellent
Choosing has C10-C18, preferably C12-C16Alkyl group and every mol of alcohol averagely about 1-15, preferably 3-12 moles of ethylene oxide（EO）
Straight chain unitary primary alconol or secondary alcohol, and there is C8-C16Alkyl group, preferably C8-C9Alkyl group and every mole phenol are averaged
About 4-12 moles EO ethoxylated alkylphenol.
The nonionic surface active agent compound of preferred classes is ethoxylated linear alcohols, such as with average about 1 to big
The C of about 12 moles of ethylene oxide ethoxylations12-C16Alcohol.Most preferred non-ionic detergent is with 3 moles of ethylene oxide second
The C of epoxide12-C15Alcohol.
The surfactant of foregoing synthetic detergent type, such as anionic and nonionic surface active agent or difference
Specific anionic or nonionic surface active agent mixture can be used for change said composition detergency, bubbling character
With other properties.For example, can by the mixture ethoxylation of the different fatty alcohols of 12 to 15 carbon atoms, direct sulphation or
The sulphation after ethoxylation, can be by fatty alcohol moieties ethoxylation and sulphation, or by ethoxylated fatty acid part
Sulphation is lived with obtaining anionic and nonionic surface active agent or different specific anionic or non-ionic surface
The mixture of property agent.When it is present, surfactant is preferably the 5-50 weight %, more preferably 8 to 30 weight % of said composition, entered
One step more preferably 10 to 25 weight %.
Beneficial agent, such as wetting agent, emollient, opacifier or anti-agingization can be incorporated in the present compositions
Compound.The example of wetting agent and emollient includes NMF such as polyalcohol, glycerine, cetanol, carbomer, ethoxylation castor-oil plant
Oil, paraffin oil, lanolin and its derivative.Organo-silicon compound, such as organic silicon surfactant can also be included, such as
DC3225C（From Dow Corning）And/or organosilicon emollient, silicone oil（DC-200 from Dow Corning）.Also
Opacifier, such as Avobenzone can be incorporated to（It can be obtained with trade name PARSOL 1789
From Givaudan）And/or methoxy cinnamic acid 2- ethylhexyls（Givaudan can be obtained from trade name PARSOL MCX）Or
Other UV-A and UV-B opacifiers.Water soluble clycol, such as propane diols, ethylene glycol, glycerine can be made with the content of highest 10%
With.Other additives can be incorporated to, such as one or more granular materials not soluble in water, such as polysaccharide such as starch or modified shallow lake
Powder and cellulose.Secondary additive includes metal ion chelation agent or sequestering agent, colorant, preservative and essence, can appoint
Selection of land is incorporated to.The soap composition of the present invention can also contain different amounts of compatible adjuvants.The typical case of such compatible adjuvants is real
Example is filler and pigment, such as titanium dioxide, diatomite, arbitrary different coloring pigments, dyestuff, spices and Optical Bleaching Agent.
Said composition can be in solid form（Such as rod, piece, chip or powder）Or in liquid form（Such as hand cleanser and shower
Composition）It is made.Said composition can be configured to frame system according to the conventional method of soapmaking technology（Casting）Soap develops soap bar.
The method for manufacturing soap bar
The method that the exemplary manufacture soap bar according to the present invention will now be described.
The soap component of the soap bar can be by the way that mixing is one or more under atmospheric pressure in open stirring reaction container
Aliphatic acid and at least one nertralizer simultaneously are heated to being enough the temperature for melting the aliphatic acid, generally at least about 80 DEG C to 90 DEG C
To manufacture.The aliphatic acid includes laurate and the mono carboxylic fat with 14 carbon atoms to the long alkyl chains of 22 carbon atoms
Acid.Nertralizer suitable for the soap bar of the manufacture present invention includes caustic liquor, such as soda such as NaOH.The nertralizer neutralizes the fat
Acid, form the salt of the aliphatic acid（That is " soap "）, such as example sodium, potassium, ammonia or alkanol ammonium salt.The nertralizer can be with less than complete
The amount addition that dosage is neutralized needed for the aliphatic acid is neutralized entirely.In the exemplary of the present invention, it can add
About 95% of the amount of nertralizer needed for the aliphatic acid is neutralized entirely.The temperature is preferably maintained above about 80 DEG C but less than about 100
℃。
Optionally at this moment, the free acid of the mixture can be analyzed, and correspondingly adjust the pH of the mixture.For example, can
To titrate the mixture with NaOH using pH indicator, and when needing, the composition of the mixture can be adjusted so that
10% aqueous solution for obtaining gained soap bar has the pH for being not more than about 9.If for example, the pH is excessively acid, in can adding more
And agent.Or if the mixture has the pH higher than about 9, more free fatties can be added into said composition.Such as
Fruit adds free fatty, and the preferably free fatty has the alkyl chain of 8 to 10 carbon atoms.
In this stage of manufacture method, the temperature of reactant mixture can bring up at least about 90 DEG C, preferably approximately
90 DEG C to about 100 DEG C to evaporate the desired amount of water.Or the water can add extra nertralizer or free as described above
The front evaporator of aliphatic acid.In one embodiment of the invention, the soap bar includes the water no more than 25%.The soap bar preferably wraps
Containing the water no more than 20%.It is highly preferred that the soap bar includes the water no more than 15%.Removed when from soap component the desired amount of
During water, the soap component can be cooled down, can also then use conventional method to add the optional member of addition
Into the soap component.Resulting composition can be by the way that the said composition of molten condition be poured into mould to be configured to
Soap bar, or form soap bar using conventional development, molding and/or punching press program as known in the art.
Sterilization method
According to the second aspect of the invention, there is provided a kind of method of disinfecting surface, comprise the following steps：
A. the composition of the present invention is applied on the surface；With
B. said composition is removed from the surface.
The surface is preferably skin.Thus, make for example similar to hand, face, body or the surface in oral cavity and the group of the present invention
Compound contacts.Or the surface is any crust.Generally, such crust is to usually require to clean and preferably also need to defend
The surface of raw processing or sterilization.Such surface can be found in many families or industrial environment, and can include such as kitchen
With bathroom surfaces, table top, floor, metope, window, vessel, tableware and pottery.Such surface can be by many different materials systems
Into, including such as plastics, timber, metal, ceramics, glass, concrete, marble and painted surface.
Said composition can be applied on the surface by any appropriate means well known by persons skilled in the art.For example,
In the case of fluid composition, suitable means can be toppled over, be added dropwise, spray or wipe.
This method be preferably included in said composition is applied to it is dilute with suitable solvent, preferably water before or while the surface
Release or dissolve said composition.Especially in the case where said composition is solid composite, this dissolving is preferable.Or may be used also
With（Such as in powder form）The solid composite is sprayed in direct spreading, friction.
The step of method of first aspect present invention also includes removing said composition from the surface.Herein, removing should
Composition also includes part and removes said composition, because the said composition of trace is likely to remain on the surface.In many typical cases
In the case of, including washed skin or hard-surface cleaning, if a part of said composition, particularly some active components remain in this
It is acceptable on surface or sometimes even desirable.Therefore, step b preferably include remove by weight at least 5%, more preferably
At least 10%, even more desirably at least 25%, even more preferably at least 50% and still more preferably at least 75% said composition.Remove the group
The step of compound, is preferably included with the suitable solvent washing surface or with the suitable wipe surface, it is highly preferred that should
Step with suitable solvent by rinsing the surface or with the suitable wipe surface composition.Or the removal step can be with
Including evaporating a part of said composition, such as when said composition includes volatile component such as solvent.
Medium suitable for rinsing the surface is water, but can also be the mixture of such as water and alcohol.In the predetermined time
Duan Hou, it is preferably rinsed to remove any visible or appreciable residue of said composition with enough water immediately.Or can
So that the antimicrobial compositions are visually not present using wipe surface of alcohol swab or water/alcohol dipping.By
In the composition surprisingly quick anti-microbial effect of the present invention, the step of removing said composition（Such as pass through flushing
Or wipe the surface）It is preferred that by said composition apply on a surface the step of start after less than 5 minutes, more preferably less than 2
Minute, even more preferably less than 1 minute, even more preferably be less than 30 seconds and even more preferably less than 20 seconds when start.Even if office
Portion's microorganism killing can almost moment occurs when applying the composition of the present invention, preferably removes said composition from the surface
The step of by said composition apply on a surface the step of start after at least 5 seconds, preferably at least 10 seconds, more preferably at least 15
Start during the second to realize optimal anti-microbial effect.These ageings into time interval be also preferable.Therefore, it is especially excellent
Choosing, from the surface the step of removal said composition（That is step b）By said composition apply on a surface the step of
（That is step a）After beginning between 2 minutes and 5 seconds, more preferably 1 minute and between 10 seconds, even more preferably 30 seconds and between 10 seconds
Even more preferably start between 20 seconds and 15 seconds.
The method of the present invention is preferably the sterilization method of non-treatment.
The purposes of the present invention
Preferably non-treatment benefit provides the present invention.Thus, for example, the present invention relates to the antimicrobial compositions of the present invention
For faster reducing the purposes of viable microbial organisms counting.
Thus, according to the third aspect of the invention we, there is provided composition of the invention is used for improved hygienic purposes.This
Class purposes, which is related to, for example to be counted for reducing viable microbial organisms, preferably quickly reduces the purposes that viable microbial organisms count.Thus, this
Class purposes is preferably the purposes in sterilization method.
Thus, there is provided composition of the invention is used for the purposes for improving human body surface health.Such surface is included for example
Skin, hand and oral cavity.According to a preferred aspect, the use for improving hand hygiene is used for the present invention relates to the composition of the present invention
On the way.According to another preferred aspect, the purposes for improving oral hygiene is used for the present invention relates to the composition of the present invention.
For a more complete understanding of the present invention and not by the mode of limitation, with reference to the following example.But this area
Ordinarily skilled artisan will understand that various modifications and changes can be carried out without departing from the scope of the present invention.Therefore, should
Embodiment is considered as illustrative and not restrictive meaning, and all such modifications are intended to be included in the scope of the present invention
It is interior.
Embodiment
Embodiment A, B and embodiment 1：Synergy between sodium laurate and antimicrobial acivity composition
Prepare the composition that is shown in table 1 and using program test its antibacterial activity being summarized below.
Scheme：Experiment is killed in contact（Contact in 15 seconds is killed）
Test organismsE.coliATCC 10536 is in TSA plates（Difco -40 g/l）（gpl）In at 37 DEG C through 16-18
Hour growth is whole night.Cell density is adjusted to acquisition 108cfu/ml（0.8 OD under 620 nm）Final counting.In sample
9 milliliters of test solution are taken in container, and add the culture of 1 milliliter of processing thereto.After the time of contact of 15 seconds, exist immediately
D/E meat soups（Difco - 39gpl）Neutralize 1 milliliter of said mixture.Serial dilution and duplicate is carried out in D/E meat soups
In TSA（Difco - 40gpl）Upper transplating board.In the case of tester, 1 milliliter of test cultures is added in 9 mL of saline
And serial dilution and in TSA upper transplating boards.After solidification, the plate is cultivated 48 hours at 37 DEG C.After 48 hours of incubation to residue
Bacterium colony is counted, and by relatively calculating effect with tester.By the log values that test solution is subtracted from culture tester
To calculate logarithm reduction.
Table 1
| Embodiment | Composition | Logarithm reduces |
| A | The thymol of 0.0625% terpineol+0.025% | 0.17 |
| B | 0.5% sodium laurate | 0.33 |
| 1 | The sodium laurate of+0.025% thymol of 0.0625% terpineol+0.5% | 7.22 |
Number in upper table 1 between the sodium laurate of the mixture and low concentration of thymol and terpineol it was demonstrated that exist
Synergistic antimicrobial activity, the mixture of wherein thymol and terpineol have low antimicrobial acivity.
Embodiment C, D and embodiment 2 to 5：Association in the presence of soap between sodium laurate and antimicrobial acivity composition
Same-action
Prepare and amount to the soap composition containing 70% soap.Said composition includes 0.5% terpineol and 0.2% thymol.Soap
The sodium laurate amount of the % forms of total amount is enumerated in table 2 below.The program of antibacterial activity is measured with being used for the identical of embodiment 1.Number
According to being summarised in table 2 below.
Table 2
| Embodiment | Antimicrobial acivity | Sodium laurate (wt% of total soap content) | Logarithm reduces |
| C | It is not present | 9.2 | 0.29 |
| D | In the presence of | 9.2 | 2.58 |
| 2 | In the presence of | 13.7 | 4.16 |
| 3 | In the presence of | 18.3 | 5.20 |
| 4 | In the presence of | 20.1 | 5.31 |
| 5 | In the presence of | 22.8 | 7.9 |
As shown by data in upper table 2, when without using antimicrobial acivity composition（Embodiment C）Or when sodium laurate amount exceeds
During claimed scope, antimicrobial acivity is low.But when sodium laurate amount is in claimed scope, obtain excellent
Different antimicrobial acivity.
Embodiment E to I and 6 to 9：Prove other antimicrobial acivity compositions and the synergy of sodium laurate
Various other antimicrobial acivity compositions and the sodium laurate shown in table 3 is used together and used and embodiment 1
In identical method used measure antimicrobial acivity.Data summarization is in table 3.
Table 3
| Embodiment | Antimicrobial acivity composition (wt%) | Sodium laurate (wt%) | Logarithm reduces |
| E | It is not present | 0.5% | 1.04 |
| F | To chloro-m-xylene (0.1%) | It is not present | 0.15 |
| 6 | To chloro-m-xylene (0.1%) | 0.5% | 7.51 |
| G | Geraniol (0.1%) | It is not present | 0.49 |
| 7 | Geraniol (0.1%) | 0.5% | 7.51 |
| H | Nerol (0.1%) | It is not present | 0.52 |
| 8 | Nerol (0.1%) | 0.5% | 7.84 |
| I | Linalool (0.1%) | It is not present | 0.26 |
| 9 | Linalool (0.1%) | 0.5% | 7.84 |
As shown by data in upper table 3, sodium laurate is used alone（Embodiment E）Or it is used alone in the present invention and is claimed
Some antimicrobial acivity compositions（Embodiment F to I）Good antimicrobial acivity can not be provided.But these combination
（Embodiment 6 to 8）Provide Synergistic antimicrobial activity.
Embodiment J to W：Lack the embodiment of activity when showing to use the surfactant in addition to sodium laurate
As shown in table 4, with antimicrobial acivity composition（0.05% terpineol and 0.02% thymol）It is used together
Various other anionic surfactant（Including various soap active materials）, but do not show shown by laruate
Activity.The data in table 4 are obtained using program same as Example 1.
Table 4
| Embodiment | Antimicrobial acivity | Surfactant (wt%) | Logarithm reduces |
| J | In the presence of | It is not present | 0.13 |
| K | It is not present | 0.4% sodium laurate | 0.04 |
| 10 | In the presence of | 0.4% sodium laurate | 5.57 |
| L | It is not present | 0.5% sodium palmitate | 0.28 |
| M | In the presence of | 0.5% sodium palmitate | 0.69 |
| N | It is not present | 0.5% enuatrol | 0.35 |
| O | In the presence of | 0.5% enuatrol | 0.42 |
| P | It is not present | 0.5% Sodium myristate | 0.32 |
| Q | In the presence of | 0.5% Sodium myristate | 2.78 |
| R | It is not present | 0.5% Sodium Caprylate | 0.20 |
| S | In the presence of | 0.5% Sodium Caprylate | 0.16 |
| T | It is not present | 0.5% odium stearate | 0.20 |
| U | In the presence of | 0.5% odium stearate | 0.59 |
| V | It is not present | 0.5% NaLS | 0.27 |
| W | In the presence of | 0.5% NaLS | 1.27 |
As shown by data in table 4, using only sodium laurate and antimicrobial acivity composition（Embodiment 10）Association can be provided
Same activity, and various similar soap or anionic surfactant（Embodiment J to W）Required high water activity can not be shown
It is flat.
By above description, it became apparent that, it is described herein and exemplified with a kind of new and effective soap
Composition, it realizes some preceding aims.
Present invention thus provides the collaboration soap composition for producing excellent antibacterial activity.
Although describing the present invention with reference to particular, it will be appreciated by those skilled in the art that the present invention can be with
Many other forms embody.
Claims (11)
1. soap composition, it is included：
A) 15 to 80 weight % soap；
B) 0.01 to 5 weight % one or more antimicrobial acivity compositions, the antimicrobial acivity composition are selected from essential oil
Active component and parachlorometaxylenol；
12 to 50 weight % of wherein described soap are lauric salt；
Wherein described active ingredients of essential oils is selected from linalool, nerol, geraniol, terpineol, thymol and its mixture.
2. composition as claimed in claim 1, wherein the antimicrobial acivity composition is the mixing of terpineol and thymol
Thing.
3. solid soap composition as claimed in claim 1 or 2, wherein the soap is 40 to 80 weight % of the composition.
4. liquid soap composition as claimed in claim 1 or 2, wherein the soap is 15 to 30 weight % of the composition.
5. composition as claimed in claim 1 or 2, wherein the lauric salt is the 12 weight % to 25 weights of the soap
Measure %.
6. composition as claimed in claim 1 or 2, wherein the lauric salt is sodium laurate or potassium laurate.
7. the non-treatment method of disinfecting surface, it comprises the following steps：
A. by the composition as described in any one of claim 1 to 6 be applied to as described on surface；With
B. the composition is removed from the surface.
8. non-treatment method as claimed in claim 7, wherein the surface is skin surface.
9. non-treatment method as claimed in claim 7 or 8, wherein being opened after the step (a) starts between 2 minutes and 5 seconds
Begin the step (b).
10. the composition as described in any one of claim 1 to 6 is used for the non-therapeutic use for improving hand hygiene.
11. the composition as described in any one of claim 1 to 6 is used for the non-therapeutic use for improving oral hygiene.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12183546 | 2012-09-07 | ||
| EP12183546.6 | 2012-09-07 | ||
| PCT/EP2013/066144 WO2014037167A1 (en) | 2012-09-07 | 2013-08-01 | Soap composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104736687A CN104736687A (en) | 2015-06-24 |
| CN104736687B true CN104736687B (en) | 2018-03-02 |
Family
ID=46826315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380057276.7A Active CN104736687B (en) | 2012-09-07 | 2013-08-01 | Soap composition |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2892991B1 (en) |
| CN (1) | CN104736687B (en) |
| BR (1) | BR112015004813B1 (en) |
| IN (1) | IN2015MN00414A (en) |
| WO (1) | WO2014037167A1 (en) |
| ZA (1) | ZA201501542B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2902011T3 (en) * | 2014-02-04 | 2018-06-29 | Basf Se | Aqueous tenside compositions |
| BR112018007651A2 (en) * | 2015-11-27 | 2018-11-06 | Unilever Nv | antimicrobial cleaning composition, method for disinfecting a surface and using a composition |
| EP3389694B1 (en) | 2015-12-14 | 2021-11-10 | Unilever Global IP Limited | An antimicrobial composition |
| CN113475539A (en) * | 2021-06-23 | 2021-10-08 | 杭州微冠科技有限公司 | Preparation method of transparent soap shoe cover epidemic prevention isolation rubber mat |
| CN113416617A (en) * | 2021-06-23 | 2021-09-21 | 杭州微冠科技有限公司 | Transparent soap key isolation rubber pad |
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|---|---|---|---|---|
| US2196763A (en) * | 1938-01-21 | 1940-04-09 | Eastman Kodak Co | Liquid antiseptic soap |
| CN1236387A (en) * | 1996-11-09 | 1999-11-24 | 雷克特和科尔曼产品有限公司 | Antiseptic soap bar |
| CN1592578A (en) * | 2001-10-04 | 2005-03-09 | 以色列国家农业部富卡尼中心 | Microbiocidal formulation comprising essential oils or their derivatives |
| WO2007065538A1 (en) * | 2005-12-07 | 2007-06-14 | Unilever Plc | Improved detergent composition |
| CN102108320A (en) * | 2009-12-24 | 2011-06-29 | 北京洛娃日化有限公司 | Mouldproof liquid detergent |
| CN102186341A (en) * | 2008-10-20 | 2011-09-14 | 荷兰联合利华有限公司 | An antimicrobial composition |
| CN102510723A (en) * | 2009-09-24 | 2012-06-20 | 荷兰联合利华有限公司 | Disinfecting agent comprising eugenol, terpineol and thymol |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9603085A (en) * | 1996-07-12 | 1998-05-05 | Cosmeticos Natural Ind Com | Liquid antiseptic soap for skin care |
-
2013
- 2013-08-01 IN IN414MUN2015 patent/IN2015MN00414A/en unknown
- 2013-08-01 EP EP13745052.4A patent/EP2892991B1/en not_active Not-in-force
- 2013-08-01 BR BR112015004813-7A patent/BR112015004813B1/en active IP Right Grant
- 2013-08-01 WO PCT/EP2013/066144 patent/WO2014037167A1/en active Application Filing
- 2013-08-01 CN CN201380057276.7A patent/CN104736687B/en active Active
-
2015
- 2015-03-06 ZA ZA2015/01542A patent/ZA201501542B/en unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2196763A (en) * | 1938-01-21 | 1940-04-09 | Eastman Kodak Co | Liquid antiseptic soap |
| CN1236387A (en) * | 1996-11-09 | 1999-11-24 | 雷克特和科尔曼产品有限公司 | Antiseptic soap bar |
| CN1592578A (en) * | 2001-10-04 | 2005-03-09 | 以色列国家农业部富卡尼中心 | Microbiocidal formulation comprising essential oils or their derivatives |
| WO2007065538A1 (en) * | 2005-12-07 | 2007-06-14 | Unilever Plc | Improved detergent composition |
| CN102186341A (en) * | 2008-10-20 | 2011-09-14 | 荷兰联合利华有限公司 | An antimicrobial composition |
| CN102510723A (en) * | 2009-09-24 | 2012-06-20 | 荷兰联合利华有限公司 | Disinfecting agent comprising eugenol, terpineol and thymol |
| CN102108320A (en) * | 2009-12-24 | 2011-06-29 | 北京洛娃日化有限公司 | Mouldproof liquid detergent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104736687A (en) | 2015-06-24 |
| BR112015004813A8 (en) | 2019-08-13 |
| BR112015004813A2 (en) | 2017-07-04 |
| BR112015004813B1 (en) | 2021-02-02 |
| WO2014037167A1 (en) | 2014-03-13 |
| ZA201501542B (en) | 2016-10-26 |
| EP2892991B1 (en) | 2016-03-02 |
| EP2892991A1 (en) | 2015-07-15 |
| IN2015MN00414A (en) | 2015-09-04 |
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